{"title":"Kinetic Study of Gluconic Acid Batch Fermentation by Aspergillus niger","authors":"Akbarningrum Fatmawati, Rudy Agustriyanto, Lindawati","volume":33,"journal":"International Journal of Chemical and Molecular Engineering","pagesStart":471,"pagesEnd":476,"ISSN":"1307-6892","URL":"https:\/\/publications.waset.org\/pdf\/9599","abstract":"Gluconic acid is one of interesting chemical products\r\nin industries such as detergents, leather, photographic, textile, and\r\nespecially in food and pharmaceutical industries. Fermentation is an\r\nadvantageous process to produce gluconic acid. Mathematical\r\nmodeling is important in the design and operation of fermentation\r\nprocess. In fact, kinetic data must be available for modeling. The\r\nkinetic parameters of gluconic acid production by Aspergillus niger\r\nin batch culture was studied in this research at initial substrate\r\nconcentration of 150, 200 and 250 g\/l. The kinetic models used were\r\nlogistic equation for growth, Luedeking-Piret equation for gluconic\r\nacid formation, and Luedeking-Piret-like equation for glucose\r\nconsumption. The Kinetic parameters in the model were obtained by\r\nminimizing non linear least squares curve fitting.","references":"[1] J.Z. Liu, L.P. Weng, Q.L. Zhang, H. Xu, L. N. Ji, \"A mathematical\r\nmodel for gluconinc acid fermentation by Aspergillus niger\",\r\nBiochemical Engineering Journal, vol. 14, pp. 15-64, 2003.\r\n[2] S. Velizarov, V. Beschkov, \"Biotransformation of glucose to free\r\ngluconic acid by Gluconobacter oxydans: substrate and product\r\ninhibition situations\", Process Biochemistry, vol. 33, no. 5, pp.527-534,\r\n1998.\r\n[3] H. Znad, J. Markos, V. Bales, \"Production of gluconic acid from glucose\r\nby Aspergillus niger: growth and non-growth conditions\", Process\r\nBiochemistry, vol. 39, pp. 1341-1345, 2004.\r\n[4] M.L. Shuler, F. Kargi, Bioprocess Engineering Basic Concept. New\r\nJersey: Prentice-Hall Inc., 1992, pp.176.\r\n[5] T. Takamatsu, S. Shioya, T. Furuya, \"Mathematical model of gluconic\r\nacid fermentation by Aspergillus niger\", J. Chem.. Technol. Biotechnol.,\r\nvol. 31, pp. 697-704, 1981.\r\n[6] H. Znad, M. Blazej, V. Bales, J. Markos, \"A kinetic model for gluconic\r\nacid production by Aspergillus niger\", Chem. Pap., vol. 58, no. 1, pp.\r\n23-28, 2004.","publisher":"World Academy of Science, Engineering and Technology","index":"Open Science Index 33, 2009"}