Biosimilar and Innovator Co-Promotions: The Changing Tide of Biosimilar Strategy

<!DOCTYPE html>   <html lang="en">  <head> <meta charset="utf-8" /> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <meta http-equiv="Content-type" content="text/html; charset=utf-8"> <meta name="viewport" content="width=device-width, initial-scale=1, maximum-scale=1, user-scalable=no"> <meta name="msapplication-TileImage" content="/Content/Shotgun/img/favicon/ms-icon-144x144.png?v=4" /> <link rel="apple-touch-icon-precomposed" href="/Content/Shotgun/img/favicon/apple-icon-precomposed.png?v=4" /> <link rel="icon" href="/Content/Shotgun/img/favicon/favicon.ico?v=4" /><style> .coveo-card-layout a::after { display: none !important; } </style> <script>(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer','GTM-P97VBCW');</script> <meta name="google-site-verification" content="EyIQB7GdOQ83t4xrzV8zE-Gs_mjfgD-VO1TZkSkbKSc" />  <title>Biosimilar and Innovator Co-Promotions: The Changing Tide of Biosimilar Strategy - IQVIA</title>  <link rel="canonical" href="https://www.iqvia.com/locations/united-states/blogs/2024/09/biosimilar-and-innovator-co-promotions" /> <meta name="keywords" content="biosimilar, innovator co-promotions, Humira, Cordavis, Hyrimoz, Sandoz, Caremark, Part D payer channels, Medicaid, Adalimumab, U.S. managed markets, Express Scripts, Teva, Quallent" /> <meta name="description" content="Explore how Cordavis’ launch and Hyrimoz’s co-promotion are transforming the adalimumab market, challenging Humira, and reshaping U.S. biosimilar strategies." /> <meta name="iq:related_solutions" content="Market Access, Market Access Strategy Consulting, Biosimilars" /> <meta name="iq:business_area" content="Safety and Regulatory Compliance,Consulting,Research & Development Solutions,Enterprise,Real World" /> <meta name="iq:market_segment" content="Consumer Health,Payers,Emerging Biopharma (EBP),Traditional or branded Pharma" /> <meta name="iq:market_product" content="IQVIA" /> <meta name="iq:region" content="North America" /> <meta name="iq:regional_business_unit" content="US & Canada,Global" /> <meta name="iq:insight_topics" content="Commercial Compliance,Market Access,Biosimilars" /> <meta name="iq:thought_leadership" content="" /> <meta property="og:title" content="Biosimilar and Innovator Co-Promotions: The Changing Tide of Biosimilar Strategy" /> <meta property="twitter:title" content="Biosimilar and Innovator Co-Promotions: The Changing Tide of Biosimilar Strategy" /> <meta property="og:image" content="https://www.iqvia.com/-/media/iqvia/images/modules/brandworld/3305_pharmaceutical-optical-ampoule.jpg" /> <meta property="twitter:image" content="https://www.iqvia.com/-/media/iqvia/images/modules/brandworld/3305_pharmaceutical-optical-ampoule.jpg" /> <meta property="og:description" content="<p><span>Ten biosimilar versions of Humira (adalimumab) have launched since 2023 but have achieved very little traction thus far, </span><a rel="noopener noreferrer" href="https://www.iqvia.com/locations/united-states/library/white-papers/lessons-from-semglee-early-perspectives-on-pharmacy-biosimilars" target="_blank"><span>largely due to the competitive pricing and rebate dynamics</span></a><span> of U.S. managed markets. In August 2023, Caremark announced the launch of Cordavis which would co-promote and commercialize Hyrimoz with Sandoz as well as AbbVie&rsquo;s Humira. This partnership came to bear in April 2024 when Caremark added Hyrimoz and &ldquo;</span><a rel="noopener noreferrer" href="https://www.cvshealth.com/news/pbm/cvs-caremark-accelerates-biosimilars-adoption-through-formulary-changes.html" target="_blank"><span>removed</span></a><span>&rdquo; Humira from major template formularies.</span></p> <p>Early reports showed Hyrimoz share rapidly increased after Caremark&rsquo;s announced formulary change, particularly within new prescriptions, instigating many conversations around the changing tide among pharmacy biosimilars in the U.S.&nbsp; Though these events are still recent, much can be learned from the early months of the evolving adalimumab landscape.</p> <br /> <h5><strong>A new business model</strong></h5> <p><span>The common strategy of rebating for access leaves little room for biosimilars to compete when innovators have the leverage of scale and are willing to negotiate steep discounts. This scenario leads some biosimilar manufacturers to opt for a two-price approach wherein one version of their biosimilar launched with higher prices and steep rebates along with another, unbranded version launched at a much lower price point that was comparable to net. Nevertheless, there has been little incentive for payers and patients to switch volume from the innovator to its biosimilars, thus enabling Humira to retain at least 97% of total adalimumab volume through March 2024.</span></p> <p><span style="text-decoration: underline;">Share of Adalimumab Claims Trend, All Payer Channels</span></p> <p><span style="text-decoration: underline;"></span><img alt="" src="-/media/b70f39338faa491b80a9f2d14653a76c.ashx?h=470&amp;w=1180" style="height: 393px; width: 1043px;" /></p> <p><em><span>Note: April 2024 marks a one-time bolus of patients switching from Humira to initiate treatment with Hyrimoz which subsides over time</span></em><br /> <em><span>Source: IQVIA LAAD Pharmacy Claims, US Market Access Strategy Consulting analysis</span></em></p> <p><span>Yet, a new business model could subvert common practices. The partnership between biosimilar manufacturer Sandoz and Caremark venture Cordavis creates an alternative path for biosimilars to offer value and disrupt the usual incentives that favor innovators. By co-promoting the biosimilar Hyrimoz through Cordavis, </span><a rel="noopener noreferrer" href="https://www.cvshealth.com/content/dam/enterprise/cvs-enterprise/pdfs/2024/Biosimilar-Cordavis-Whitepaper.pdf" target="_blank"><span>Caremark is able to ensure a steady supply for its specialty pharmacy and likely share in the sales</span></a><span>. As such, Hyrimoz accounted for 14% of all U.S. adalimumab claims in April 2024 and 16% in June 2024 (up from 1% the month before the venture launched). These trends were observed across commercial and Part D payer channels but not Medicaid.</span></p> <p><span>Shortly after the Cordavis co-promotion of Hyrimoz launched, a Cordavis version of Humira also entered the market. By June 2024, 5% of all adalimumab claims and 11% of all new patients were using the Cordavis version of Humira. </span><a rel="noopener noreferrer" href="https://ir.tevapharm.com/news-and-events/press-releases/press-release-details/2024/U.S.-Commercialization-Agreement-with-Quallent-to-Drive-Patient-Savings-with-First-High-Concentration-Citrate-Free-Interchangeable-Biosimilar-to-Humira-adalimumab/default.aspx" target="_blank"><span>Express Scripts&rsquo; co-promotion with Teva&rsquo;s unbranded biosimilar and Humira through distributor Quallent</span></a><span> also launched in June 2024, promising savings and </span><a rel="noopener noreferrer" href="https://www.evernorth.com/articles/evernorth-announces-humira-biosimilar-available-0-out-pocket-accredo-patients-june" target="_blank"><span>$0 out-of-pocket</span></a><span> costs through its specialty pharmacy, Accredo. With two large pharmacy benefit managers pursuing co-promotion, the paradigm of parity access between Humira&nbsp; select biosimilars may be short-lived.</span></p> <br /> <h5><span><strong>Muted innovator attrition</strong></span></h5> <p><span>The recent success of Hyrimoz does not quite foretell the end of Humira, partly because the strategy has not been more widely adopted and partly because Humira&rsquo;s own co-promotion with Cordavis (and now Quallent) delays loss of volume to a competitor. In 2024 so far, 23% of patients that switched from Humira to another adalimumab filled the co-promoted Humira and 60% filled co-promoted Hyrimoz. </span></p> <p>Co-promotions facilitated patient switching in a way that was previously unobserved for adalimumab biosimilars despite interchangeability and parity access. Stable patients (which make up more than 90% of the adalimumab market) tend to remain with their current therapy and are largely unaffected by new formulary exclusions. With a co-promotion, however, PBMs have the option to move continuing patients to a discounted biosimilar <em>or</em> co-promoted version of the innovator. As the number of adalimumab patients switching from the innovator to a biosimilar or co-promotion increases, Humira retains volume that could otherwise have been lost to a biosimilar.</p> <p><span style="text-decoration: underline;">Distribution of Humira Switches to Biosimilar, All Payer Channels</span></p> <p><span style="text-decoration: underline;"><img alt="" style="height: 320px; width: 1054px;" src="-/media/0c81b45e7c9546b591fa9704adb71ef6.ashx?h=422&amp;w=1180" /></span></p> <p><em><span>Note: Patients that move from Humira to co-promoted Humira are counted as a switch in this analysis</span></em><br /> <span>Source: MAAS Pharmacy Biosimilar Library, US Market Access Strategy Consulting analysis</span></p> <p>Before Caremark launched Cordavis, nearly all patient starts on an adalimumab biosimilar were na&iuml;ve to treatment as opposed to switching from Humira. Still, biosimilars only made up a small proportion of new starts. In 2023, only 2% of treatment na&iuml;ve patients initiated adalimumab therapy with a biosimilar. In 2024 to date, that number increased to 14%, including biosimilars and the Humira co-promotion. Nevertheless, Humira continues to make up 86% of new adalimumab patients in 2024 to date.</p> <p>Within a given biosimilar&rsquo;s new patient starts, most have switched from the innovator Humira. Though not all Humira patients are switching to a biosimilar or co-promotion, very few new biosimilar patients are treatment na&iuml;ve or switched from another biosimilar. Hyrimoz and its unbranded adalimumab-adaz have some of the highest proportions of na&iuml;ve patients apart from Humira, which is exclusively made up of adalimumab-na&iuml;ve patients. Though switching patterns could evolve as Quallent implements its own co-promotions.</p> <p><span style="text-decoration: underline;">New adalimumab Patients by Source of Business, All Channels, Jan 2023-Jun 2024</span></p> <p><span style="text-decoration: underline;"><img alt="" style="height: 395px; width: 931px;" src="-/media/a530abe531e04d7692e5d0d9e8be023c.ashx?h=468&amp;w=1180" /></span></p> <p><em><span>Note: Patients that move from Humira to co-promoted Humira are counted as a switch in this analysis</span></em><br /> <em><span>Source: MAAS Pharmacy Biosimilar Library, US Market Access Strategy Consulting analysis</span></em></p> <br /> <h5><span><strong>Rewriting the playbook</strong></span></h5> <p><span>At the time of Humira&rsquo;s loss of exclusivity, it was unclear what role interchangeability and concentration could have on biosimilar access and uptake. Formularies continued to cover the innovator, and some biosimilars launched multiple versions, offering both low list prices and discounted high prices.</span></p> <p><span>A co-promotion, made possible by PBMs&rsquo; vertical integration of specialty pharmacies and benefit management, sidesteps some of these early strategies and aligns interests for innovators, biosimilars, and payers alike: PBMS are able to leverage their specialty pharmacies to move volume through discounted co-promotions. Biosimilars gain high-value access to PBMs&rsquo; large patient populations compared to other contracts, and innovators continue treating their patient populations at a discount. Co-promotions may even benefit patients if their treatment is uninterrupted, and cost-sharing reflects these deep discounts.</span></p> <p><span>It is too early to say whether a co-promotion arrangement is the definitive biosimilar strategy. While the arrangement appears like a win-win-win across stakeholders, it is unknown exactly how the math works out for any particular party. Moreover, it is too early to tell whether the healthcare system or patients will experience savings from the new strategy. Will other PBMs and payers adopt similar strategies? Are co-promotions reasonable for all biosimilar molecules? How might co-promotions differ between private insurance and Medicare Part D where pharmacy networks are less impactful?</span></p> <p>There is even a chance that co-promotions will hamper biosimilar savings by selecting only a few biosimilars to negotiate against an innovator. This could not only make discounting less aggressive but could also disincentivize some manufacturers from developing biosimilars altogether.</p>" /> <meta property="twitter:description" content="<p><span>Ten biosimilar versions of Humira (adalimumab) have launched since 2023 but have achieved very little traction thus far, </span><a rel="noopener noreferrer" href="https://www.iqvia.com/locations/united-states/library/white-papers/lessons-from-semglee-early-perspectives-on-pharmacy-biosimilars" target="_blank"><span>largely due to the competitive pricing and rebate dynamics</span></a><span> of U.S. managed markets. In August 2023, Caremark announced the launch of Cordavis which would co-promote and commercialize Hyrimoz with Sandoz as well as AbbVie&rsquo;s Humira. This partnership came to bear in April 2024 when Caremark added Hyrimoz and &ldquo;</span><a rel="noopener noreferrer" href="https://www.cvshealth.com/news/pbm/cvs-caremark-accelerates-biosimilars-adoption-through-formulary-changes.html" target="_blank"><span>removed</span></a><span>&rdquo; Humira from major template formularies.</span></p> <p>Early reports showed Hyrimoz share rapidly increased after Caremark&rsquo;s announced formulary change, particularly within new prescriptions, instigating many conversations around the changing tide among pharmacy biosimilars in the U.S.&nbsp; Though these events are still recent, much can be learned from the early months of the evolving adalimumab landscape.</p> <br /> <h5><strong>A new business model</strong></h5> <p><span>The common strategy of rebating for access leaves little room for biosimilars to compete when innovators have the leverage of scale and are willing to negotiate steep discounts. This scenario leads some biosimilar manufacturers to opt for a two-price approach wherein one version of their biosimilar launched with higher prices and steep rebates along with another, unbranded version launched at a much lower price point that was comparable to net. Nevertheless, there has been little incentive for payers and patients to switch volume from the innovator to its biosimilars, thus enabling Humira to retain at least 97% of total adalimumab volume through March 2024.</span></p> <p><span style="text-decoration: underline;">Share of Adalimumab Claims Trend, All Payer Channels</span></p> <p><span style="text-decoration: underline;"></span><img alt="" src="-/media/b70f39338faa491b80a9f2d14653a76c.ashx?h=470&amp;w=1180" style="height: 393px; width: 1043px;" /></p> <p><em><span>Note: April 2024 marks a one-time bolus of patients switching from Humira to initiate treatment with Hyrimoz which subsides over time</span></em><br /> <em><span>Source: IQVIA LAAD Pharmacy Claims, US Market Access Strategy Consulting analysis</span></em></p> <p><span>Yet, a new business model could subvert common practices. The partnership between biosimilar manufacturer Sandoz and Caremark venture Cordavis creates an alternative path for biosimilars to offer value and disrupt the usual incentives that favor innovators. By co-promoting the biosimilar Hyrimoz through Cordavis, </span><a rel="noopener noreferrer" href="https://www.cvshealth.com/content/dam/enterprise/cvs-enterprise/pdfs/2024/Biosimilar-Cordavis-Whitepaper.pdf" target="_blank"><span>Caremark is able to ensure a steady supply for its specialty pharmacy and likely share in the sales</span></a><span>. As such, Hyrimoz accounted for 14% of all U.S. adalimumab claims in April 2024 and 16% in June 2024 (up from 1% the month before the venture launched). These trends were observed across commercial and Part D payer channels but not Medicaid.</span></p> <p><span>Shortly after the Cordavis co-promotion of Hyrimoz launched, a Cordavis version of Humira also entered the market. By June 2024, 5% of all adalimumab claims and 11% of all new patients were using the Cordavis version of Humira. </span><a rel="noopener noreferrer" href="https://ir.tevapharm.com/news-and-events/press-releases/press-release-details/2024/U.S.-Commercialization-Agreement-with-Quallent-to-Drive-Patient-Savings-with-First-High-Concentration-Citrate-Free-Interchangeable-Biosimilar-to-Humira-adalimumab/default.aspx" target="_blank"><span>Express Scripts&rsquo; co-promotion with Teva&rsquo;s unbranded biosimilar and Humira through distributor Quallent</span></a><span> also launched in June 2024, promising savings and </span><a rel="noopener noreferrer" href="https://www.evernorth.com/articles/evernorth-announces-humira-biosimilar-available-0-out-pocket-accredo-patients-june" target="_blank"><span>$0 out-of-pocket</span></a><span> costs through its specialty pharmacy, Accredo. With two large pharmacy benefit managers pursuing co-promotion, the paradigm of parity access between Humira&nbsp; select biosimilars may be short-lived.</span></p> <br /> <h5><span><strong>Muted innovator attrition</strong></span></h5> <p><span>The recent success of Hyrimoz does not quite foretell the end of Humira, partly because the strategy has not been more widely adopted and partly because Humira&rsquo;s own co-promotion with Cordavis (and now Quallent) delays loss of volume to a competitor. In 2024 so far, 23% of patients that switched from Humira to another adalimumab filled the co-promoted Humira and 60% filled co-promoted Hyrimoz. </span></p> <p>Co-promotions facilitated patient switching in a way that was previously unobserved for adalimumab biosimilars despite interchangeability and parity access. Stable patients (which make up more than 90% of the adalimumab market) tend to remain with their current therapy and are largely unaffected by new formulary exclusions. With a co-promotion, however, PBMs have the option to move continuing patients to a discounted biosimilar <em>or</em> co-promoted version of the innovator. As the number of adalimumab patients switching from the innovator to a biosimilar or co-promotion increases, Humira retains volume that could otherwise have been lost to a biosimilar.</p> <p><span style="text-decoration: underline;">Distribution of Humira Switches to Biosimilar, All Payer Channels</span></p> <p><span style="text-decoration: underline;"><img alt="" style="height: 320px; width: 1054px;" src="-/media/0c81b45e7c9546b591fa9704adb71ef6.ashx?h=422&amp;w=1180" /></span></p> <p><em><span>Note: Patients that move from Humira to co-promoted Humira are counted as a switch in this analysis</span></em><br /> <span>Source: MAAS Pharmacy Biosimilar Library, US Market Access Strategy Consulting analysis</span></p> <p>Before Caremark launched Cordavis, nearly all patient starts on an adalimumab biosimilar were na&iuml;ve to treatment as opposed to switching from Humira. Still, biosimilars only made up a small proportion of new starts. In 2023, only 2% of treatment na&iuml;ve patients initiated adalimumab therapy with a biosimilar. In 2024 to date, that number increased to 14%, including biosimilars and the Humira co-promotion. Nevertheless, Humira continues to make up 86% of new adalimumab patients in 2024 to date.</p> <p>Within a given biosimilar&rsquo;s new patient starts, most have switched from the innovator Humira. Though not all Humira patients are switching to a biosimilar or co-promotion, very few new biosimilar patients are treatment na&iuml;ve or switched from another biosimilar. Hyrimoz and its unbranded adalimumab-adaz have some of the highest proportions of na&iuml;ve patients apart from Humira, which is exclusively made up of adalimumab-na&iuml;ve patients. Though switching patterns could evolve as Quallent implements its own co-promotions.</p> <p><span style="text-decoration: underline;">New adalimumab Patients by Source of Business, All Channels, Jan 2023-Jun 2024</span></p> <p><span style="text-decoration: underline;"><img alt="" style="height: 395px; width: 931px;" src="-/media/a530abe531e04d7692e5d0d9e8be023c.ashx?h=468&amp;w=1180" /></span></p> <p><em><span>Note: Patients that move from Humira to co-promoted Humira are counted as a switch in this analysis</span></em><br /> <em><span>Source: MAAS Pharmacy Biosimilar Library, US Market Access Strategy Consulting analysis</span></em></p> <br /> <h5><span><strong>Rewriting the playbook</strong></span></h5> <p><span>At the time of Humira&rsquo;s loss of exclusivity, it was unclear what role interchangeability and concentration could have on biosimilar access and uptake. Formularies continued to cover the innovator, and some biosimilars launched multiple versions, offering both low list prices and discounted high prices.</span></p> <p><span>A co-promotion, made possible by PBMs&rsquo; vertical integration of specialty pharmacies and benefit management, sidesteps some of these early strategies and aligns interests for innovators, biosimilars, and payers alike: PBMS are able to leverage their specialty pharmacies to move volume through discounted co-promotions. Biosimilars gain high-value access to PBMs&rsquo; large patient populations compared to other contracts, and innovators continue treating their patient populations at a discount. Co-promotions may even benefit patients if their treatment is uninterrupted, and cost-sharing reflects these deep discounts.</span></p> <p><span>It is too early to say whether a co-promotion arrangement is the definitive biosimilar strategy. While the arrangement appears like a win-win-win across stakeholders, it is unknown exactly how the math works out for any particular party. Moreover, it is too early to tell whether the healthcare system or patients will experience savings from the new strategy. Will other PBMs and payers adopt similar strategies? Are co-promotions reasonable for all biosimilar molecules? How might co-promotions differ between private insurance and Medicare Part D where pharmacy networks are less impactful?</span></p> <p>There is even a chance that co-promotions will hamper biosimilar savings by selecting only a few biosimilars to negotiate against an innovator. This could not only make discounting less aggressive but could also disincentivize some manufacturers from developing biosimilars altogether.</p>" /> <meta property="og:url" content="https://www.iqvia.com/locations/united-states/blogs/2024/09/biosimilar-and-innovator-co-promotions" /> <meta property="twitter:site" content="https://www.iqvia.com/locations/united-states/blogs/2024/09/biosimilar-and-innovator-co-promotions" /> <link href="/Content/Shotgun/css/coveo?v=5f2TXK9t8FlC_0aw4cAoVYcmCiwv63sB9xo1gz4KnGg1" rel="stylesheet"/> <link href="/Content/Shotgun/css/main?v=R2OdW1uvbPjT4Hyp9vUX2IxrR3HCzyWr38h5Y4R6OTE1" rel="stylesheet"/> <link rel="stylesheet" href="https://fonts.googleapis.com/css2?family=Noto+Sans:wght@100;200;300;400;500;700;800;900&display=swap" /> <script src="/Content/Shotgun/scripts/static-plugin?v=f3VnY7U-htz3FTaboMFxbQGPAfw5M25cLJ4xxMeKTPk1"></script> </head> <body>  <script>window.isContactKnown = false</script> <div class="all-page-wrapper"> <header class="header"> 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style="float:left"> <li><a href="https://www.iqvia.com/locations/asia-pacific">Asia Pacific</a></li> <li><a href="https://www.iqvia.com/locations/australia-and-new-zealand">Australia & NZ</a></li> <li><a href="https://www.iqvia.com/zh-cn/locations/china">中国</a></li> <li><a href="https://www.iqvia.com/locations/india">India</a></li> </ul> <ul class="sub-list" style="float:left"> <li><a href="https://www.iqvia.com/ja-jp/locations/japan">Japan</a></li> <li><a href="https://www.iqvia.com/ko-kr/locations/korea">대한민국</a></li> <li><a href="https://www.iqvia.com/locations/southeast-asia">Southeast Asia</a></li> <li><a href="https://www.iqvia.com/locations/sri-lanka">Sri Lanka</a></li> </ul> </div> </li> <li> <img src="/-/media/iqvia/images/navigation/regions-eastern-europe.svg"> <div class="d-block"> <h3>Europe</h3> </div> <div class="sub-content"> <h6>Europe</h6> <ul class="sub-list" style="float:left"> <li><a href="https://www.iqvia.com/locations/adriatic">Adriatic</a></li> <li><a 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href="https://www.iqvia.com/locations/nordics">Nordics</a></li> <li><a href="https://www.iqvia.com/pl-pl/locations/poland">Poland</a></li> <li><a href="https://www.iqvia.com/pt-pt/locations/portugal">Portugal</a></li> <li><a href="https://www.iqvia.com/locations/romania">Romania</a></li> <li><a href="https://www.iqvia.com/locations/russia">Russia</a></li> <li><a href="https://www.iqvia.com/locations/slovakia">Slovakia</a></li> <li><a href="https://www.iqvia.com/locations/switzerland">Switzerland</a></li> <li><a href="https://www.iqvia.com/locations/turkey">Turkey</a></li> <li><a href="https://www.iqvia.com/locations/ukraine">Ukraine</a></li> <li><a href="https://www.iqvia.com/locations/united-kingdom">United Kingdom</a></li> </ul> </div> <div class="regional-promoted mobile"> <div class="w-65"> <div class="w-33"> <div class="card-wrapper"> <div class="card"> <img 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mobile-toggle-navigation-bar"><span></span><span></span><span></span></div> <nav class="d-flex justify-between" aria-label="Primary"> <ol class="primary-nav w-100"> <li> <a class="color-white" href="#">Who We Help</a> <div class="primary-nav-wrapper"> <div class="content solution-selector"> <div class="shadow"></div> <div class="d-flex flex-column "> <div class="d-flex flex-column"> <div class="d-flex tab"> <div class="w-20 d-flex flex-column list"> <h5 class="sub-title ">WHO WE HELP</h5> <ol class="solution-tabs open-first"> <li class="tab-title cursor-pointer d-flex align-center"> <a class="list-item-style text-decoration-none after-none" href="https://www.iqvia.com/locations/united-states/solutions/life-sciences">Pharmaceutical Manufacturers</a> <div class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="7.029" height="12" viewBox="0 0 7.029 12"> <g id="Chevron" transform="translate(-135.26 -19.823)"> <rect id="Rectangle_125" data-name="Rectangle 125" width="8.521" 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</li> <li class="tab-title cursor-pointer d-flex align-center"> <a class="list-item-style text-decoration-none after-none" href="https://www.iqvia.com/locations/united-states/solutions/healthcare-solutions/providers-segment">Hospital and Health Systems</a> <div class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="7.029" height="12" viewBox="0 0 7.029 12"> <g id="Chevron" transform="translate(-135.26 -19.823)"> <rect id="Rectangle_125" data-name="Rectangle 125" width="8.521" height="1.42" rx="0.71" transform="translate(136.264 19.823) rotate(45)" fill="#959ca0"></rect> <rect id="Rectangle_126" data-name="Rectangle 126" width="8.521" height="1.42" rx="0.71" transform="translate(135.26 30.819) rotate(-45)" fill="#959ca0"></rect> </g> </svg> </div> </li> <li class="tab-title cursor-pointer d-flex align-center"> <a class="list-item-style text-decoration-none after-none" href="https://www.iqvia.com/locations/united-states/solutions/healthcare-solutions/insurer-and-risk-solutions">Insurers and Risk</a> <div class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="7.029" height="12" viewBox="0 0 7.029 12"> <g id="Chevron" transform="translate(-135.26 -19.823)"> <rect id="Rectangle_125" data-name="Rectangle 125" width="8.521" height="1.42" rx="0.71" transform="translate(136.264 19.823) rotate(45)" fill="#959ca0"></rect> <rect id="Rectangle_126" data-name="Rectangle 126" width="8.521" height="1.42" rx="0.71" transform="translate(135.26 30.819) rotate(-45)" fill="#959ca0"></rect> </g> </svg> </div> </li> <li class="tab-title cursor-pointer d-flex align-center"> <a class="list-item-style text-decoration-none after-none" href="https://www.iqvia.com/locations/united-states/solutions/healthcare-solutions/medical-specialty-societies">Medical Specialty and Patient Advocacy</a> <div class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="7.029" height="12" viewBox="0 0 7.029 12"> <g id="Chevron" transform="translate(-135.26 -19.823)"> <rect id="Rectangle_125" data-name="Rectangle 125" width="8.521" height="1.42" rx="0.71" transform="translate(136.264 19.823) rotate(45)" fill="#959ca0"></rect> <rect id="Rectangle_126" data-name="Rectangle 126" width="8.521" height="1.42" rx="0.71" transform="translate(135.26 30.819) rotate(-45)" fill="#959ca0"></rect> </g> </svg> </div> </li> </ol> </div> <div class="w-80 tab-content solutions"> <div class="item h-100 default-content mt-0"> </div> <div class="item bg h-100 align-center"> <div class="d-flex align-center w-100 "> <div class="w-33"> <h3>Pharmaceutical Manufacturers</h3> <p>Harness unparalleled healthcare data, advanced analytics, and cutting-edge technologies with our expertise to accelerate the development and commercialization of innovative medicines, enhancing patient lives.</p> <a class="btn" href="https://www.iqvia.com/locations/united-states/solutions/life-sciences" style="max-width: 303px;">Discover More</a> </div> <div class="w-33"> <h6 class="pt-0 border-left pb-11 mt-0">Pharmaceutical Manufacturers</h6> <ol class="border-left"> <li class="hover-color-blue"><a href="https://www.iqvia.com/locations/united-states/solutions/life-sciences/commercial-solutions">Commercial Solutions</a></li> <li class="hover-color-blue"><a href="https://www.iqvia.com/locations/united-states/solutions/life-sciences/contract-sales-and-medical-solutions">Contract Sales and Medical Solutions</a></li> <li class="hover-color-blue"><a href="https://www.iqvia.com/locations/united-states/solutions/digital-enablement-center-of-excellence">Digital Enablement Center of Excellence</a></li> <li class="hover-color-blue"><a href="https://www.iqvia.com/locations/united-states/solutions/life-sciences/information-solutions">Information Solutions</a></li> <li class="hover-color-blue"><a href="https://www.iqvia.com/locations/united-states/solutions/life-sciences/medical-affairs">Medical Affairs</a></li> <li class="hover-color-blue"><a href="https://www.iqvia.com/locations/united-states/solutions/life-sciences/real-world-evidence">Real World Evidence</a></li> </ol> </div> </div> </div> <div class="item bg h-100 align-center"> <div class="d-flex align-center w-100 no-links"> <div class="w-33"> <img src="/-/media/iqvia/images/modules/brandworld/920_group-of-people-looking-at-data-during-business-meeting.jpg?h=683&w=1024&hash=9F1D12445AA35397B08A93A0D4506A73"> </div> <div class="w-33"> <h3>Emerging Biopharma (Global page)</h3> <p>Boost your innovation with IQVIA's expert team. Our comprehensive solutions integrate top-tier insights, technology, and expertise to maximize your asset's success in a competitive landscape.</p> <a class="btn" href="https://www.iqvia.com/solutions/industry-segments/emerging-biopharma" style="max-width: 303px;">Discover Innovations</a> </div> </div> </div> <div class="item bg h-100 align-center"> <div class="d-flex align-center w-100 "> <div class="w-33"> <h3>MedTech</h3> <p>Navigating MedTech's unique landscape: U.S. decision-making now rests with GPOs, IDNs, and payers, who demand solid value proof through rigorous outcomes analyses and pricing scrutiny.</p> <a class="btn" href="https://www.iqvia.com/locations/united-states/solutions/medical-device-and-diagnostic-segment" style="max-width: 303px;">Explore MedTech</a> </div> <div class="w-33"> <h6 class="pt-0 border-left pb-11 mt-0">MedTech</h6> <ol class="border-left"> <li class="hover-color-blue"><a href="https://www.iqvia.com/locations/united-states/solutions/medical-device-and-diagnostic-segment/commercial-field-solutions">Commercial Field Solutions</a></li> <li class="hover-color-blue"><a href="https://www.iqvia.com/locations/united-states/solutions/medical-device-and-diagnostic-segment/hospital-procedures-and-diagnosis">Hospital Procedures and Diagnosis</a></li> <li class="hover-color-blue"><a href="https://www.iqvia.com/locations/united-states/solutions/medical-device-and-diagnostic-segment/medical-device-supply-audit">Medical Device Supply Audit</a></li> <li class="hover-color-blue"><a href="https://www.iqvia.com/locations/united-states/solutions/medical-device-and-diagnostic-segment/medtech-business-insights-and-trends-podcast-series">MedTech Business Insights and Trends Podcast Series</a></li> <li class="hover-color-blue"><a href="https://www.iqvia.com/locations/united-states/solutions/medical-device-and-diagnostic-segment/medtech-market-activator-platform">MedTech Market Activator Platform</a></li> </ol> </div> </div> </div> <div class="item bg h-100 align-center"> <div class="d-flex align-center w-100 no-links"> <div class="w-33"> <img src="/-/media/iqvia/images/modules/brandworld/441_custom-photo_two-professionals-focused-on-laptop-information---copy_600.jpg?h=683&w=1024&hash=6C0045E8A4B73FC243BD062B0CE70586"> </div> <div class="w-33"> <h3>Financial Institutions</h3> <p>Invest in healthcare with confidence. Stay ahead of pharma and medical device trends using real-time, high-quality data. Access market insights, historical sales, prescription trends, and emerging product information for informed, risk-reduced decisions.</p> <a class="btn" href="https://www.iqvia.com/locations/united-states/solutions/life-sciences/financial-services" style="max-width: 303px;">Access Insights</a> </div> </div> </div> <div class="item bg h-100 align-center"> <div class="d-flex align-center w-100 "> <div class="w-33"> <h3>Government and Public Health</h3> <p>Unlock deeper health insights with unmatched data and innovative technology to enhance decision-making for your essential government programs.</p> <a class="btn" href="https://www.iqvia.com/locations/united-states/solutions/government-segment" style="max-width: 303px;">Unlock Innovations</a> </div> <div class="w-33"> <h6 class="pt-0 border-left pb-11 mt-0">Government and Public Health</h6> <ol class="border-left"> <li class="hover-color-blue"><a href="https://www.iqvia.com/locations/united-states/solutions/government-segment/government-solutions">CIO-CS</a></li> </ol> </div> </div> </div> <div class="item bg h-100 align-center"> <div class="d-flex align-center w-100 no-links"> <div class="w-33"> <img src="/-/media/iqvia/images/modules/brandworld/490_custom-photo_professional-carefully-reviewing-data-information.jpg?h=683&w=1024&hash=3C77D651DBA851B8FED8D62CDCB4CFC6"> </div> <div class="w-33"> <h3>Health Plans</h3> <p>Accelerate digital innovation with our data-driven expertise in data science and healthcare, optimizing business processes for smarter decisions.</p> <a class="btn" href="https://www.iqvia.com/locations/united-states/solutions/healthcare-solutions/payers-segment" style="max-width: 303px;">Navigate Health Plans</a> </div> </div> </div> <div class="item bg h-100 align-center"> <div class="d-flex align-center w-100 "> <div class="w-33"> <h3>Hospital and Health Systems</h3> <p>Leverage digital innovation to cut costs, boost efficiency, and elevate patient engagement, all while enhancing quality and health outcomes.</p> <a class="btn" href="https://www.iqvia.com/locations/united-states/solutions/healthcare-solutions/providers-segment" style="max-width: 303px;">Streamline Decisions</a> </div> <div class="w-33"> <h6 class="pt-0 border-left pb-11 mt-0">Hospital and Health Systems</h6> <ol class="border-left"> <li class="hover-color-blue"><a href="https://www.iqvia.com/locations/united-states/solutions/healthcare-solutions/providers-segment/hospital-data-exchange-program">Hospital Data Exchange Program</a></li> </ol> </div> </div> </div> <div class="item bg h-100 align-center"> <div class="d-flex align-center w-100 no-links"> <div class="w-33"> <img src="/-/media/iqvia/images/modules/brandworld/2137_it-professionals-programming-in-coding-language.png?h=576&w=1024&hash=E95DC0942533073BFAC07BFBCA46877D"> </div> <div class="w-33"> <h3>Insurers and Risk</h3> <p>Enhance your ability to evaluate and forecast population risk swiftly and accurately by integrating unmatched data, expertise, and technology. </p> <a class="btn" href="https://www.iqvia.com/locations/united-states/solutions/healthcare-solutions/insurer-and-risk-solutions" style="max-width: 303px;">Uncover More</a> </div> </div> </div> <div class="item bg h-100 align-center"> <div class="d-flex align-center w-100 no-links"> <div class="w-33"> <img src="/-/media/iqvia/images/modules/brandworld/2436_doctor-and-nurse-with-digital-tablet-talking.png?h=619&w=1024&hash=98E8877207191BDCEB7979FB8FB2BDF8"> </div> <div class="w-33"> <h3>Medical Specialty and Patient Advocacy</h3> <p>Transform into a data-driven organization that enhances your specialty and showcases value to your members through digital transformation. </p> <a class="btn" href="https://www.iqvia.com/locations/united-states/solutions/healthcare-solutions/medical-specialty-societies" style="max-width: 303px;">Explore Now</a> </div> </div> </div> </div> </div> </div> </div> </div> </div> </li> <li> <a class="color-white" href="#">Insights</a> <div class="primary-nav-wrapper"> <div class="content insights"> <div class="shadow"></div> <div class="d-flex remove-last"> <div class="w-50"> <div class="d-flex pt-75"> <div class="w-50"> <h5>U.S. PROGRESS POINT</h5> <p>A curation of IQVIA's best thinking on topics and trends driving change, disruption, and progress in the United States healthcare market.</p> <a class="hover-color-blue-with-anim" href="https://www.iqvia.com/locations/united-states/us-progress-point"> LEARN MORE <div class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="7.029" height="12" viewBox="0 0 7.029 12"> <g id="Chevron" transform="translate(-135.26 -19.823)"> <rect id="Rectangle_125" data-name="Rectangle 125" width="8.521" height="1.42" rx="0.71" transform="translate(136.264 19.823) rotate(45)" fill="#959ca0"></rect> <rect id="Rectangle_126" data-name="Rectangle 126" width="8.521" height="1.42" rx="0.71" transform="translate(135.26 30.819) rotate(-45)" fill="#959ca0"></rect> </g> </svg> </div> </a> </div> <div class="w-50"> <h5>BLOGS, WHITE PAPERS & CASE STUDIES</h5> <p>Explore our library of insights, thought leadership, and the latest topics & trends in healthcare.</p> <a class="hover-color-blue-with-anim" href="https://www.iqvia.com/locations/united-states/insights"> DISCOVER INSIGHTS <div class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="7.029" height="12" viewBox="0 0 7.029 12"> <g id="Chevron" transform="translate(-135.26 -19.823)"> <rect id="Rectangle_125" data-name="Rectangle 125" width="8.521" height="1.42" rx="0.71" transform="translate(136.264 19.823) rotate(45)" fill="#959ca0"></rect> <rect id="Rectangle_126" data-name="Rectangle 126" width="8.521" height="1.42" rx="0.71" transform="translate(135.26 30.819) rotate(-45)" fill="#959ca0"></rect> </g> </svg> </div> </a> </div> </div> </div> <div class="w-65"> <div class="d-flex"> <div class="w-33"> <div class="card-wrapper"> <div class="card"> <img src="/-/media/iqvia/images/modules/brandworld/2447_woman-watching-business-training-on-laptop-and-learning-from-home.jpg?h=800&w=1200&hash=7138103CD56C8FC464E41DA86DD886F0"> <h5 class="title">PODCASTS</h5> <p class="description">Discover the future through our enlightening podcasts available in the United States.</p> <a class="hover-color-blue-with-anim" href="https://www.iqvia.com/locations/united-states/insights#f:type=[Podcast]"> EXPLORE PODCASTS <div class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="7.029" height="12" viewBox="0 0 7.029 12"> <g id="Chevron" transform="translate(-135.26 -19.823)"> <rect id="Rectangle_125" data-name="Rectangle 125" width="8.521" height="1.42" rx="0.71" transform="translate(136.264 19.823) rotate(45)" fill="#959ca0"></rect> <rect id="Rectangle_126" data-name="Rectangle 126" width="8.521" height="1.42" rx="0.71" transform="translate(135.26 30.819) rotate(-45)" fill="#959ca0"></rect> </g> </svg> </div> </a> </div> </div> </div> <div class="w-33"> <div class="card-wrapper"> <div class="card"> <img src="/-/media/iqvia/images/modules/brandworld/2082_team-working-together-in-modern-office.jpg?h=800&w=1200&hash=4757AE4478988C1A78F643C9F597F3F9"> <h5 class="title">FACT SHEET</h5> <p class="description">IQVIA AI Medical Record Review</p> <a class="hover-color-blue-with-anim" href="https://www.iqvia.com/locations/united-states/library/fact-sheets/iqvia-ai-medical-record-review"> LEARN MORE <div class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="7.029" height="12" viewBox="0 0 7.029 12"> <g id="Chevron" transform="translate(-135.26 -19.823)"> <rect id="Rectangle_125" data-name="Rectangle 125" width="8.521" height="1.42" rx="0.71" transform="translate(136.264 19.823) rotate(45)" fill="#959ca0"></rect> <rect id="Rectangle_126" data-name="Rectangle 126" width="8.521" height="1.42" rx="0.71" transform="translate(135.26 30.819) rotate(-45)" fill="#959ca0"></rect> </g> </svg> </div> </a> </div> </div> </div> <div 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</svg> </div> </li> <li> Hospital and Health Systems <div class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="7.029" height="12" viewBox="0 0 7.029 12"> <g id="Chevron" transform="translate(-135.26 -19.823)"> <rect id="Rectangle_125" data-name="Rectangle 125" width="8.521" height="1.42" rx="0.71" transform="translate(136.264 19.823) rotate(45)" fill="#959ca0"></rect> <rect id="Rectangle_126" data-name="Rectangle 126" width="8.521" height="1.42" rx="0.71" transform="translate(135.26 30.819) rotate(-45)" fill="#959ca0"></rect> </g> </svg> </div> </li> <li> Insurers and Risk <div class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="7.029" height="12" viewBox="0 0 7.029 12"> <g id="Chevron" transform="translate(-135.26 -19.823)"> <rect id="Rectangle_125" data-name="Rectangle 125" width="8.521" height="1.42" rx="0.71" transform="translate(136.264 19.823) rotate(45)" fill="#959ca0"></rect> <rect id="Rectangle_126" data-name="Rectangle 126" width="8.521" height="1.42" 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href="https://www.iqvia.com/locations/united-states/solutions/life-sciences">Discover More</a> <div class="hr"></div> <h6>Pharmaceutical Manufacturers</h6> <ul> <li><a href="https://www.iqvia.com/locations/united-states/solutions/life-sciences/commercial-solutions">Commercial Solutions</a></li> <li><a href="https://www.iqvia.com/locations/united-states/solutions/life-sciences/contract-sales-and-medical-solutions">Contract Sales and Medical Solutions</a></li> <li><a href="https://www.iqvia.com/locations/united-states/solutions/digital-enablement-center-of-excellence">Digital Enablement Center of Excellence</a></li> <li><a href="https://www.iqvia.com/locations/united-states/solutions/life-sciences/information-solutions">Information Solutions</a></li> <li><a href="https://www.iqvia.com/locations/united-states/solutions/life-sciences/medical-affairs">Medical Affairs</a></li> <li><a href="https://www.iqvia.com/locations/united-states/solutions/life-sciences/real-world-evidence">Real World Evidence</a></li> </ul> </div> <div class="tab-item"> <img src="/-/media/iqvia/images/modules/brandworld/920_group-of-people-looking-at-data-during-business-meeting.jpg?h=683&w=1024&hash=9F1D12445AA35397B08A93A0D4506A73"> <h5>Emerging Biopharma (Global page)</h5> <p>Boost your innovation with IQVIA's expert team. Our comprehensive solutions integrate top-tier insights, technology, and expertise to maximize your asset's success in a competitive landscape.</p> <a class="btn w-auto mt-30" href="https://www.iqvia.com/solutions/industry-segments/emerging-biopharma">Discover Innovations</a> </div> <div class="tab-item"> <h5>MedTech</h5> <p>Navigating MedTech's unique landscape: U.S. decision-making now rests with GPOs, IDNs, and payers, who demand solid value proof through rigorous outcomes analyses and pricing scrutiny.</p> <a class="btn" href="https://www.iqvia.com/locations/united-states/solutions/medical-device-and-diagnostic-segment">Explore MedTech</a> <div class="hr"></div> <h6>MedTech</h6> <ul> <li><a href="https://www.iqvia.com/locations/united-states/solutions/medical-device-and-diagnostic-segment/commercial-field-solutions">Commercial Field Solutions</a></li> <li><a href="https://www.iqvia.com/locations/united-states/solutions/medical-device-and-diagnostic-segment/hospital-procedures-and-diagnosis">Hospital Procedures and Diagnosis</a></li> <li><a href="https://www.iqvia.com/locations/united-states/solutions/medical-device-and-diagnostic-segment/medical-device-supply-audit">Medical Device Supply Audit</a></li> <li><a href="https://www.iqvia.com/locations/united-states/solutions/medical-device-and-diagnostic-segment/medtech-business-insights-and-trends-podcast-series">MedTech Business Insights and Trends Podcast Series</a></li> <li><a href="https://www.iqvia.com/locations/united-states/solutions/medical-device-and-diagnostic-segment/medtech-market-activator-platform">MedTech Market Activator Platform</a></li> </ul> </div> <div class="tab-item"> <img src="/-/media/iqvia/images/modules/brandworld/441_custom-photo_two-professionals-focused-on-laptop-information---copy_600.jpg?h=683&w=1024&hash=6C0045E8A4B73FC243BD062B0CE70586"> <h5>Financial Institutions</h5> <p>Invest in healthcare with confidence. Stay ahead of pharma and medical device trends using real-time, high-quality data. Access market insights, historical sales, prescription trends, and emerging product information for informed, risk-reduced decisions.</p> <a class="btn w-auto mt-30" href="https://www.iqvia.com/locations/united-states/solutions/life-sciences/financial-services">Access Insights</a> </div> <div class="tab-item"> <h5>Government and Public Health</h5> <p>Unlock deeper health insights with unmatched data and innovative technology to enhance decision-making for your essential government programs.</p> <a class="btn" href="https://www.iqvia.com/locations/united-states/solutions/government-segment">Unlock Innovations</a> <div class="hr"></div> <h6>Government and Public Health</h6> <ul> <li><a href="https://www.iqvia.com/locations/united-states/solutions/government-segment/government-solutions">CIO-CS</a></li> </ul> </div> <div class="tab-item"> <img src="/-/media/iqvia/images/modules/brandworld/490_custom-photo_professional-carefully-reviewing-data-information.jpg?h=683&w=1024&hash=3C77D651DBA851B8FED8D62CDCB4CFC6"> <h5>Health Plans</h5> <p>Accelerate digital innovation with our data-driven expertise in data science and healthcare, optimizing business processes for smarter decisions.</p> <a class="btn w-auto mt-30" href="https://www.iqvia.com/locations/united-states/solutions/healthcare-solutions/payers-segment">Navigate Health Plans</a> </div> <div class="tab-item"> <h5>Hospital and Health Systems</h5> <p>Leverage digital innovation to cut costs, boost efficiency, and elevate patient engagement, all while enhancing quality and health outcomes.</p> <a class="btn" href="https://www.iqvia.com/locations/united-states/solutions/healthcare-solutions/providers-segment">Streamline Decisions</a> <div class="hr"></div> <h6>Hospital and Health Systems</h6> <ul> <li><a href="https://www.iqvia.com/locations/united-states/solutions/healthcare-solutions/providers-segment/hospital-data-exchange-program">Hospital Data Exchange Program</a></li> </ul> </div> <div class="tab-item"> <img src="/-/media/iqvia/images/modules/brandworld/2137_it-professionals-programming-in-coding-language.png?h=576&w=1024&hash=E95DC0942533073BFAC07BFBCA46877D"> <h5>Insurers and Risk</h5> <p>Enhance your ability to evaluate and forecast population risk swiftly and accurately by integrating unmatched data, expertise, and technology. </p> <a class="btn w-auto mt-30" href="https://www.iqvia.com/locations/united-states/solutions/healthcare-solutions/insurer-and-risk-solutions">Uncover More</a> </div> <div class="tab-item"> <img src="/-/media/iqvia/images/modules/brandworld/2436_doctor-and-nurse-with-digital-tablet-talking.png?h=619&w=1024&hash=98E8877207191BDCEB7979FB8FB2BDF8"> <h5>Medical Specialty and Patient Advocacy</h5> <p>Transform into a data-driven organization that enhances your specialty and showcases value to your members through digital transformation. </p> <a class="btn w-auto mt-30" href="https://www.iqvia.com/locations/united-states/solutions/healthcare-solutions/medical-specialty-societies">Explore Now</a> </div> </div> </div> <div class="item-wrapper-mobile list pb-0" data-attribute="insights"> <div class="breadcrumbs"><span class="go-home">MAIN</span>/<span>Insights</span></div> <div class="breadcrumbs d-none" style="padding-bottom:30px;"><span class="go-main">Insights</span>/<span></span></div> <div class="lists"> <div class="tab-item"> <h5 class="title-sm">U.S. PROGRESS POINT</h5> <p>A curation of IQVIA's best thinking on topics and trends driving change, disruption, and progress in the United States healthcare market.</p> <a class="btn-redirect" href="https://www.iqvia.com/locations/united-states/us-progress-point" target="_blank"> LEARN MORE <div class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="7.029" height="12" viewBox="0 0 7.029 12"> <g id="Chevron" transform="translate(-135.26 -19.823)"> <rect id="Rectangle_125" data-name="Rectangle 125" width="8.521" height="1.42" rx="0.71" transform="translate(136.264 19.823) rotate(45)" fill="#959ca0"></rect> <rect id="Rectangle_126" data-name="Rectangle 126" width="8.521" height="1.42" rx="0.71" transform="translate(135.26 30.819) rotate(-45)" fill="#959ca0"></rect> </g> </svg> </div> </a> </div> <div class="tab-item"> <h5 class="title-sm">BLOGS, WHITE PAPERS & CASE STUDIES</h5> <p>Explore our library of insights, thought leadership, and the latest topics & trends in healthcare.</p> <a class="btn-redirect" href="https://www.iqvia.com/locations/united-states/insights" target="_blank"> DISCOVER INSIGHTS <div class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="7.029" height="12" viewBox="0 0 7.029 12"> <g id="Chevron" transform="translate(-135.26 -19.823)"> <rect id="Rectangle_125" data-name="Rectangle 125" width="8.521" height="1.42" rx="0.71" 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U.S. Market Access Strategy Consulting, IQVIA</div> <div>Ruthy Glass, PhD, Manager, U.S. Market Access Strategy Consulting, IQVIA</div> </div> <div class="time">Sep 04, 2024</div> </div> </div> </div> <div class="hero-breadcrumbs padding z_index breadcrumbs-hero_outer"> <div class="breadcrumbs breadcrumbs-hero_inner"> <ul class="breadcrumbs__list"> <li class="breadcrumbs__item"> <a href="https://www.iqvia.com/"><span class="iqvia-icon-home"></span></a> </li> <li class="breadcrumbs__item"> <a href="https://www.iqvia.com/locations">Locations</a> </li> <li class="breadcrumbs__item"> <a href="https://www.iqvia.com/locations/united-states">United States</a> </li> <li class="breadcrumbs__item"> <a href="https://www.iqvia.com/locations/united-states/blogs">US Blogs</a> </li> <li class="breadcrumbs__item"> <span>Biosimilar and Innovator Co-Promotions: The Changing Tide of Biosimilar Strategy</span> </li> </ul> </div> </div> </div> </section> <section class="share-bar-redesign"> <div class="share-bar-wrapper"> <button class="share-bar-container"> <p> Share PAGE <img alt="Share PAGE" src="/Content/Shotgun/img/icons/social_icons/new/Share.svg" /> </p> <ul class="dropdown"> <li title="Copy link to clipboard" data-event="copy"> <span>Copy Link</span> <img src="/Content/Shotgun/img/icons/social_icons/new/Copy.svg" /> </li> </ul> </button> </div> </section> <section class="insights-detail-body-redesign "> <div class="insights-detail-body-redesign__outer"> <div class="insights-detail-body-redesign__inner"> <p><span>Ten biosimilar versions of Humira (adalimumab) have launched since 2023 but have achieved very little traction thus far, </span><a rel="noopener noreferrer" href="https://www.iqvia.com/locations/united-states/library/white-papers/lessons-from-semglee-early-perspectives-on-pharmacy-biosimilars" target="_blank"><span>largely due to the competitive pricing and rebate dynamics</span></a><span> of U.S. managed markets. In August 2023, Caremark announced the launch of Cordavis which would co-promote and commercialize Hyrimoz with Sandoz as well as AbbVie’s Humira. This partnership came to bear in April 2024 when Caremark added Hyrimoz and “</span><a rel="noopener noreferrer" href="https://www.cvshealth.com/news/pbm/cvs-caremark-accelerates-biosimilars-adoption-through-formulary-changes.html" target="_blank"><span>removed</span></a><span>” Humira from major template formularies.</span></p> <p>Early reports showed Hyrimoz share rapidly increased after Caremark’s announced formulary change, particularly within new prescriptions, instigating many conversations around the changing tide among pharmacy biosimilars in the U.S.  Though these events are still recent, much can be learned from the early months of the evolving adalimumab landscape.</p> <br /> <h5><strong>A new business model</strong></h5> <p><span>The common strategy of rebating for access leaves little room for biosimilars to compete when innovators have the leverage of scale and are willing to negotiate steep discounts. This scenario leads some biosimilar manufacturers to opt for a two-price approach wherein one version of their biosimilar launched with higher prices and steep rebates along with another, unbranded version launched at a much lower price point that was comparable to net. Nevertheless, there has been little incentive for payers and patients to switch volume from the innovator to its biosimilars, thus enabling Humira to retain at least 97% of total adalimumab volume through March 2024.</span></p> <p><span style="text-decoration: underline;">Share of Adalimumab Claims Trend, All Payer Channels</span></p> <p><span style="text-decoration: underline;"></span><img alt="" src="/-/media/iqvia/images/united-states/blogs/2024/image-1_exhibits-adalimumab-copromotion-blog.jpg?h=470&w=1180&hash=DE0C6E3469C194F46875838FC504F30E" style="width: 1043px;" class="img-responsive" data-img-height="393px" /></p> <p><em><span>Note: April 2024 marks a one-time bolus of patients switching from Humira to initiate treatment with Hyrimoz which subsides over time</span></em><br /> <em><span>Source: IQVIA LAAD Pharmacy Claims, US Market Access Strategy Consulting analysis</span></em></p> <p><span>Yet, a new business model could subvert common practices. The partnership between biosimilar manufacturer Sandoz and Caremark venture Cordavis creates an alternative path for biosimilars to offer value and disrupt the usual incentives that favor innovators. By co-promoting the biosimilar Hyrimoz through Cordavis, </span><a rel="noopener noreferrer" href="https://www.cvshealth.com/content/dam/enterprise/cvs-enterprise/pdfs/2024/Biosimilar-Cordavis-Whitepaper.pdf" target="_blank"><span>Caremark is able to ensure a steady supply for its specialty pharmacy and likely share in the sales</span></a><span>. As such, Hyrimoz accounted for 14% of all U.S. adalimumab claims in April 2024 and 16% in June 2024 (up from 1% the month before the venture launched). These trends were observed across commercial and Part D payer channels but not Medicaid.</span></p> <p><span>Shortly after the Cordavis co-promotion of Hyrimoz launched, a Cordavis version of Humira also entered the market. By June 2024, 5% of all adalimumab claims and 11% of all new patients were using the Cordavis version of Humira. </span><a rel="noopener noreferrer" href="https://ir.tevapharm.com/news-and-events/press-releases/press-release-details/2024/U.S.-Commercialization-Agreement-with-Quallent-to-Drive-Patient-Savings-with-First-High-Concentration-Citrate-Free-Interchangeable-Biosimilar-to-Humira-adalimumab/default.aspx" target="_blank"><span>Express Scripts’ co-promotion with Teva’s unbranded biosimilar and Humira through distributor Quallent</span></a><span> also launched in June 2024, promising savings and </span><a rel="noopener noreferrer" href="https://www.evernorth.com/articles/evernorth-announces-humira-biosimilar-available-0-out-pocket-accredo-patients-june" target="_blank"><span>$0 out-of-pocket</span></a><span> costs through its specialty pharmacy, Accredo. With two large pharmacy benefit managers pursuing co-promotion, the paradigm of parity access between Humira  select biosimilars may be short-lived.</span></p> <br /> <h5><span><strong>Muted innovator attrition</strong></span></h5> <p><span>The recent success of Hyrimoz does not quite foretell the end of Humira, partly because the strategy has not been more widely adopted and partly because Humira’s own co-promotion with Cordavis (and now Quallent) delays loss of volume to a competitor. In 2024 so far, 23% of patients that switched from Humira to another adalimumab filled the co-promoted Humira and 60% filled co-promoted Hyrimoz. </span></p> <p>Co-promotions facilitated patient switching in a way that was previously unobserved for adalimumab biosimilars despite interchangeability and parity access. Stable patients (which make up more than 90% of the adalimumab market) tend to remain with their current therapy and are largely unaffected by new formulary exclusions. With a co-promotion, however, PBMs have the option to move continuing patients to a discounted biosimilar <em>or</em> co-promoted version of the innovator. As the number of adalimumab patients switching from the innovator to a biosimilar or co-promotion increases, Humira retains volume that could otherwise have been lost to a biosimilar.</p> <p><span style="text-decoration: underline;">Distribution of Humira Switches to Biosimilar, All Payer Channels</span></p> <p><span style="text-decoration: underline;"><img alt="" style="width: 1054px;" src="/-/media/iqvia/images/united-states/blogs/2024/image-2_exhibits-adalimumab-copromotion-blog.jpg?h=422&w=1180&hash=F4C466E6A0624BCD5D01335392AA40BE" class="img-responsive" data-img-height="320px" /></span></p> <p><em><span>Note: Patients that move from Humira to co-promoted Humira are counted as a switch in this analysis</span></em><br /> <span>Source: MAAS Pharmacy Biosimilar Library, US Market Access Strategy Consulting analysis</span></p> <p>Before Caremark launched Cordavis, nearly all patient starts on an adalimumab biosimilar were naïve to treatment as opposed to switching from Humira. Still, biosimilars only made up a small proportion of new starts. In 2023, only 2% of treatment naïve patients initiated adalimumab therapy with a biosimilar. In 2024 to date, that number increased to 14%, including biosimilars and the Humira co-promotion. Nevertheless, Humira continues to make up 86% of new adalimumab patients in 2024 to date.</p> <p>Within a given biosimilar’s new patient starts, most have switched from the innovator Humira. Though not all Humira patients are switching to a biosimilar or co-promotion, very few new biosimilar patients are treatment naïve or switched from another biosimilar. Hyrimoz and its unbranded adalimumab-adaz have some of the highest proportions of naïve patients apart from Humira, which is exclusively made up of adalimumab-naïve patients. Though switching patterns could evolve as Quallent implements its own co-promotions.</p> <p><span style="text-decoration: underline;">New adalimumab Patients by Source of Business, All Channels, Jan 2023-Jun 2024</span></p> <p><span style="text-decoration: underline;"><img alt="" style="width: 931px;" src="/-/media/iqvia/images/united-states/blogs/2024/image-3_exhibits-adalimumab-copromotion-blog.jpg?h=468&w=1180&hash=4E58B69DA8445260A19ECD8FB3DBCED8" class="img-responsive" data-img-height="395px" /></span></p> <p><em><span>Note: Patients that move from Humira to co-promoted Humira are counted as a switch in this analysis</span></em><br /> <em><span>Source: MAAS Pharmacy Biosimilar Library, US Market Access Strategy Consulting analysis</span></em></p> <br /> <h5><span><strong>Rewriting the playbook</strong></span></h5> <p><span>At the time of Humira’s loss of exclusivity, it was unclear what role interchangeability and concentration could have on biosimilar access and uptake. Formularies continued to cover the innovator, and some biosimilars launched multiple versions, offering both low list prices and discounted high prices.</span></p> <p><span>A co-promotion, made possible by PBMs’ vertical integration of specialty pharmacies and benefit management, sidesteps some of these early strategies and aligns interests for innovators, biosimilars, and payers alike: PBMS are able to leverage their specialty pharmacies to move volume through discounted co-promotions. Biosimilars gain high-value access to PBMs’ large patient populations compared to other contracts, and innovators continue treating their patient populations at a discount. Co-promotions may even benefit patients if their treatment is uninterrupted, and cost-sharing reflects these deep discounts.</span></p> <p><span>It is too early to say whether a co-promotion arrangement is the definitive biosimilar strategy. While the arrangement appears like a win-win-win across stakeholders, it is unknown exactly how the math works out for any particular party. Moreover, it is too early to tell whether the healthcare system or patients will experience savings from the new strategy. Will other PBMs and payers adopt similar strategies? Are co-promotions reasonable for all biosimilar molecules? How might co-promotions differ between private insurance and Medicare Part D where pharmacy networks are less impactful?</span></p> <p>There is even a chance that co-promotions will hamper biosimilar savings by selecting only a few biosimilars to negotiate against an innovator. This could not only make discounting less aggressive but could also disincentivize some manufacturers from developing biosimilars altogether.</p> </div> </div> </section> <section class="fifty-fifty-redesign"> <div class="fifty-fifty-redesign__outer" data-aos="fade-up"> <div class="fifty-fifty-redesign__wrapper"> <div class="fifty-fifty-redesign__inner"> <div class="fifty-fifty-redesign__image"> <div class="fifty-fifty-redesign__image-box"> <img src="/-/media/iqvia/images/modules/brandworld/408_custom-photo_nhs-doctor-meeting-with-patient.jpg?mw=700&hash=602EF2CE416119FB394B8CB3F5E40037" alt="The Human Data Science Company" class="main-image rounded"/> </div> </div> <div class="fifty-fifty-redesign__content"> <h3 class="fifty-fifty-redesign__heading"> IQVIA’S Market Access Center of Excellence </h3> <div class="fifty-fifty-redesign__text"> <p>In a time when better access has never mattered more, IQVIA has built the largest and most experienced market access team in the industry. 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Biosimilar and Innovator Co-Promotions: The Changing Tide of Biosimilar Strategy - IQVIA