PAD for Drug Development

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href="https://missionbio.com/products/pharma-assay-development/">Pharma Assay Development</a></span> <span class="bread-arrow"></span> <span class="breadcrumb_last" aria-current="page">PAD for Drug Development</span></span></div></div> <section id="pad-hero" class="pad-hero dark_mobile" style="background-image: url('https://missionbio.com/wp-content/uploads/2024/04/33db2b9102e14977e3c148b6a286e8c9.png')"> <div class="_1300-container inner-content"> <div class="apps-cols"> <div class="mission-copy"> <h1 class="h2-thin nm w">Characterize Disease  to Accelerate Precision Medicine</h1> <div class="description"><p>Our PAD team is your strategic partner for single-cell assay design, sample processing, data analysis and visualization. Whether providing internal services or working with a CRO, we can speed up your success.</p> </div> <a style="color: #ffffff; margin: 30px 0 0 0; padding-top: 9px; padding-bottom: 9px;" class="button" href="#get_started" target="">GET STARTED</a> </div> </div> </div> </section> <section id="pad-panels-categories"> <div class="panels-categories"> <div class="_1300-container inner-content capabilities-links"> <div class="panels-links"> <a href="#pad-why" class="cap-link">KEY BENEFITS</a> <a href="#accordion_block" class="cap-link">APPLICATIONS</a> <a href="#pad-concept_study" class="cap-link">PROOF OF CONCEPT STUDY</a> <a href="#applications-resources" class="cap-link">RESOURCES</a> </div> </div> </div> </section> <section id="pad-why" class="pad-why"> <div class="_1300-container inner-content"> <h2 class="section-title">Why PAD Services for Therapeutic Development</h2> <div class="description"><p>PAD services are the easiest way to access single-cell insights via the Tapestri platform.  From understanding therapy resistance mechanisms that are impossible to obtain through traditional methodologies to precision disease profiling and therapeutic characterization that provide a deeper understanding of the patient journey, PAD services are your link to uniquely insightful, actionable data at any development stage.</p> </div> <div class="accordion_block" id="accordion_block"> <div class="accordion"> <div class="accordion-item"> <div class="accordion-title"> <div class="title" style="background: #EB2334">DISCOVERY <div class="plus_icon"> <span class="line1" style="background: #EB2334"></span> <span class="line2" style="background: #EB2334"></span> </div> </div> </div> <div class="accordion-content"> <div class="content_with_arrow"> <div class="left_long_arrow" style="background: #EB2334"></div> <div class="accordion-main-content"> <div class="top_list"> <div class="top_list_item half"> <div class="title_with_long_arrow"> <h4 class="title">Pre-Discovery</h4> <div class="long_arrow" style="background: #EB2334"></div> </div> <div class="description"><p><strong>Goals</strong>: Understanding of the processes and pathways underlying disease, which can provide important insights into potential therapeutic targets and strategies.</p> </div> </div> <div class="top_list_item half"> <div class="title_with_long_arrow"> <h4 class="title">Target Identification</h4> <div class="long_arrow" style="background: #EB2334"></div> </div> <div class="description"><p>Identify specific molecules that play a crucial role in a disease state and ensure that the targets are druggable to produce beneficial and therapeutic effects.</p> </div> </div> </div> <div class="bottom_list"> <div class="bottom_list_title"> <h4 class="title" style="background: #717171">How Tapestri Helps</h4> <div class="line" style="background: #717171"></div> </div> <div class="bottom_list_description"><ul> <li>Identify the molecular mechanisms (gene lesions/ surface protein) relevant to disease.</li> <li>Characterize the clonal trajectories involved in tumor development and progression.</li> <li>Dissect the molecular heterogeneity of the target throughout the course of disease to determine if they are correlated with disease exacerbation or progression.</li> <li>Dissect the intratumoral heterogeneity that could lead to cancer adaptation and therapeutic failure.</li> </ul> </div> </div> </div> </div> </div> </div> <div class="accordion-item"> <div class="accordion-title"> <div class="title" style="background: #53B4D3">TRANSLATIONAL <div class="plus_icon"> <span class="line1" style="background: #53B4D3"></span> <span class="line2" style="background: #53B4D3"></span> </div> </div> </div> <div class="accordion-content"> <div class="content_with_arrow"> <div class="left_long_arrow" style="background: #53B4D3"></div> <div class="accordion-main-content"> <div class="top_list"> <div class="top_list_item half"> <div class="title_with_long_arrow"> <h4 class="title">Target Validation</h4> <div class="long_arrow" style="background: #53B4D3"></div> </div> <div class="description"><p><strong>Goals</strong>: Extensive experiments to validate whether modulating the target will result in the desired therapeutic effects.</p> </div> </div> <div class="top_list_item two-thirds"> <div class="title_with_long_arrow"> <h4 class="title">Lead Discovery & Optimization</h4> <div class="long_arrow" style="background: #53B4D3"></div> </div> <div class="title_with_long_arrow"> <h4 class="title">Preclinical Dev</h4> <div class="long_arrow" style="background: #53B4D3"></div> </div> <div class="description"><p>HTS to evaluate 10,000 + cpds to identify those that interact with the target.<br /> ID lead cpd/s and optimize for potency and specificity.<br /> Preclinical testing on in vivo animal models to determine the efficacy and safety of the drug, PK/PD, immunogenicity and dosing.</p> </div> </div> </div> <div class="bottom_list"> <div class="bottom_list_title"> <h4 class="title" style="background: #717171">How Tapestri Helps</h4> <div class="line" style="background: #717171"></div> </div> <div class="bottom_list_description"><p><strong>Target Validation</strong></p> <ul> <li>Dissect the molecular heterogeneity and evolution of the target/s in disease models to determine if they correlate with disease progression.</li> <li>Identify the acquisition of resistance mechanisms that could alter potency of targeted therapies.</li> <li>Confirm that PDX model recapitulate disease from the patient it was derived from.</li> </ul> <p><strong>Lead Discovery & Optimization / Preclinical Dev</strong></p> <ul> <li>Measure therapeutic efficiency of agents to ID lead compound.</li> <li>Track genetic and immunophenotypic changes that alter potency of lead compound.</li> </ul> </div> </div> </div> </div> </div> </div> <div class="accordion-item"> <div class="accordion-title"> <div class="title" style="background: #717171">CLINICAL <div class="plus_icon"> <span class="line1" style="background: #717171"></span> <span class="line2" style="background: #717171"></span> </div> </div> </div> <div class="accordion-content"> <div class="content_with_arrow"> <div class="left_long_arrow" style="background: #717171"></div> <div class="accordion-main-content"> <div class="top_list"> <div class="top_list_item half"> <div class="description"><p><strong>Goals</strong>: Clinical trials involve human participants. Provide information on efficacy, safety, PK/PD and dosing and interaction with other drugs.</p> <p><strong>Phase 1</strong>: 20-80 human subjects</p> <p><strong>Phase 2</strong>: 100-300 human subjects</p> <p><strong>Phase 3</strong>: 1000-3000 human subjects</p> </div> </div> </div> <div class="bottom_list"> <div class="bottom_list_title"> <h4 class="title" style="background: #717171">How Tapestri Helps</h4> <div class="line" style="background: #717171"></div> </div> <div class="bottom_list_description"><ul> <li>Predictive biomarker screening to identify responders vs non responders and improve patient stratification.</li> <li>Track genetic and immunophenotypic changes to measure therapeutic efficiency and changes that alter potency of lead compound.</li> <li>Predict relapse on remission timepoints.</li> </ul> </div> </div> </div> </div> </div> </div> </div> </div> </div> </section> <section id="pad-concept_study" class="pad-concept_study"> <div class="image"> <img src="https://missionbio.com/wp-content/uploads/2024/04/Replaced_Screen.png" alt="Image" style="clip-path: polygon(0 0, 75% 0, 100% 100%, 0% 100%);"> </div> <div class="_1300-container inner-content"> <div class="concept_study_heading"> <div class="image"> </div> <div class="title_block"> <h2 class="section-title">PAD Proof of  Concept Study</h2> <h4 class="section-subtitle">A look at your samples  using our single-cell lens</h4> </div> </div> <div class="description_list"> <div class="description_list_item"> <div class="text"><p>Get a side-by-side comparison of your orthogonal dataset against Tapestri’s  single-cell multi-omics and see what was missed. Our Proof of Concept Study will allow you to test drive Mission Bio’s innovative technology on a small sample set and experience working with our assay development team, R&D organization, and bioinformatics support.</p> </div> <div class="title">Our oncology experts partner with you to:</div> <div class="list"> <div class="list_item"><ul> <li>Scope your single cell multi-omics   project with the goal of uncovering   therapeutic resistance</li> <li>Identify high impact longitudinal sample   sets that indicate clinical relevance</li> </ul> </div> <div class="list_item"><ul> <li>Deliver a comprehensive report that   highlights therapeutic insights</li> <li>Deliver next-generation clinical trial   design for better patient stratification</li> </ul> </div> </div> </div> <div class="description_list_item"> <div class="text"><p>Your raw data will be analyzed by expert bioinformaticians and you’ll receive a comprehensive report, summarizing study design and single-cell data interpretation on SNVs, indels, chromosomal rearrangements and CNVs; as well as structural characteristics like zygosity, mutational co-occurrence, and the presence of rare cell populations.</p> </div> <div class="list"> <div class="list_item"><ul> <li>Sequencing performance metrics</li> <li>Target panel performance metrics</li> <li>Bulk sequencing data compared with   single-cell sequencing</li> </ul> </div> <div class="list_item"><ul> <li>Clonal phylogeny</li> <li>SNV and CNV analysis</li> <li>Immunophenotyping & cell lineage</li> <li>UMAP clustering & FISH plots</li> </ul> </div> </div> </div> </div> </div> </section> <section id="applications-resources" class="h-resources" style=""> <div class="_1300-container inner-content"> <h2 class="section_title w" style="">Driving Success Through PAD Partnership</h2> <div class="h-resources-grid"> <div class="h-resource-card tn" data-ix="show-more-link"> <div class="h-resource-image tn" ></div> <div class="h-resource-content"> <div class="h-resource-category d tn"> PRESS RELEASE </div> <a href="https://missionbio.com/press/servier-partnership-aml-tibsovo/" class="h-resource-title-link"> Servier leverages Mission Bio’s Tapestri® Platform to uncover AML resistance mechanisms in pivotal TIBSOVO® (ivosidenib) clinical trial </a> <br/> <a href="https://missionbio.com/press/servier-partnership-aml-tibsovo/" class="more-link">LEARN MORE</a> </div> </div> <div class="h-resource-divider"></div> <div class="h-resource-card tn" data-ix="show-more-link"> <div class="h-resource-image tn" ></div> <div class="h-resource-content"> <div class="h-resource-category d tn"> PRESS RELEASE </div> <a href="https://missionbio.com/press/validation-study-aml/" class="h-resource-title-link"> Mission Bio’s Tapestri® Platform Demonstrates Highly Robust And Reproducible Data </a> <br/> <a href="https://missionbio.com/press/validation-study-aml/" class="more-link">LEARN MORE</a> </div> </div> <div class="h-resource-divider"></div> <div class="h-resource-card b" data-ix="show-more-link"> <div class="h-resource-image b" style="background-image: url(/wp-content/themes/missionbio-v2/images-2/brochures.jpg);"></div> <div class="h-resource-content"> <div class="h-resource-category d br">brochures</div> <a href="https://missionbio.com/resources/brochures/pad-pilot-program/" class="h-resource-title-link"> PAD Pilot Program </a> <br/> <a href="https://missionbio.com/resources/brochures/pad-pilot-program/" class="more-link">LEARN MORE</a> </div> </div> </div> </div> </section> <section id="get_started" class="pharma-assay-get_started"> <div class="cta red r"> <div class="_1300-container inner-content cta"> <h3 class="h3 w">Get Started</h3> <div class="mb30 w">Contact us to begin your evaluation</div> <a href="/company/contact/" class="button w wo r w-button">CONTACT US</a> </div> </div> </section> <script type="text/javascript" src="https://missionbio.com/wp-content/themes/missionbio-v2/js/jquery-3.4.1.min.js?ver=1590639462" id="jquery-js"></script> <script type="text/javascript" src="https://missionbio.com/wp-content/themes/missionbio-v2/js/swiper-bundle.min.js?ver=1.0" id="swiper-script-js"></script> <script type="text/javascript" src="https://missionbio.com/wp-content/themes/missionbio-v2/js/slick.min.js?ver=1.0" id="slick-script-js"></script> <script type="text/javascript" src="https://missionbio.com/wp-content/themes/missionbio-v2/js/mission-bio.js?ver=1666878465" id="mb-scripts-js"></script> <script type="text/javascript" src="https://missionbio.com/wp-content/themes/missionbio-v2/script.js?ver=1727345272" id="mb-main-js"></script> <script type="text/javascript" src="https://missionbio.com/wp-content/plugins/pardot/js/asyncdc.min.js?ver=6.7" id="pddc-js"></script> <div class="g-footer"> <div class="_1300-container inner-content"> <div class="g-footer-grid"> <div class="g-footer-col-logo"> <a href="/" class="g-footer-logo w-inline-block"> <img src="/wp-content/themes/missionbio-v2/images/MB-Logo-Stacked-White.svg" alt=""> </a> <div class="g-footer-social-grid"> <a target="_blank" href="https://twitter.com/missionbio?lang=en" class="g-footer-social-link tw w-inline-block"></a> <a target="_blank" href="https://www.facebook.com/missionbio/" class="g-footer-social-link fb w-inline-block"></a> <a target="_blank" href="https://www.linkedin.com/company/mission-bio" class="g-footer-social-link ln w-inline-block"></a> <a target="_blank" href="https://www.youtube.com/channel/UC3xFKde4blclowu-FbYMFeA" class="g-footer-social-link yt w-inline-block"></a> </div> <div class="g-footer-title">HEADQUARTERS</div> <div class="address">400 E Jamie Court, Suite 100<br>South San Francisco, CA 94080</div> <a href="tel:+14158540058" class="g-footer-link mb">+1 (415) 854-0058</a> <a href="mailto:info@missionbio.com" class="g-footer-link">info@missionbio.com</a> <div class="f-copyright">©2024 Mission Bio. 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