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class="menu-topic-bar">Research Topics</div> <div class="node__content"> <div class="layout layout--onecol"> <div class="layout__region layout__region--content"> <div class="block block-nhlbi-utils block-nhlbi-global-breadcrumb"> <div class="responsive-container responsive-container-constrained breadcrumbs-container"><div class="breadcrumbs"><ul> <li class='breadcrumb-home'><a href='/'>Home</a></li><li class='breacrumb-break'><i class="fas fa-angle-right"></i></li><li class='breadcrumb-parent'><a href='/node/129758'><span class='back-to'> < Back To </span>Research Topics</a></li><li class='breacrumb-break'><i class="fas fa-angle-right"></i></li><li class='breadcrumb-current'>Newborn Breathing Conditions Research</li></ul></div></div> </div> <div class="block block-layout-builder block-extra-field-blocknoderesearch-topicscontent-moderation-control"> </div> </div> </div> <div class="layout layout--onecol"> <div class="layout__region layout__region--content"> <div class="block block-addtoany block-addtoany-block"> <div class="responsive-container responsive-container-constrained"> <span class="a2a_kit a2a_kit_size_24 addtoany_list" data-a2a-url="https://www.nhlbi.nih.gov/research/newborn-breathing-conditions" data-a2a-title="Newborn Breathing Conditions Research"> <a class="a2a_dd addtoany_share" href="https://www.addtoany.com/share#url=https%3A%2F%2Fwww.nhlbi.nih.gov%2Fresearch%2Fnewborn-breathing-conditions&title=Newborn%20Breathing%20Conditions%20Research"> <img src="/themes/custom/nhlbi/images/share-alt-icon.svg" alt="Share"> </a> <a class="a2a_button_email"></a> <a class="a2a_button_print"></a> </span> </div> </div> <div class="block block-layout-builder block-field-blocknoderesearch-topicstitle"> <h1 class="field field--name-title field--type-string field--label-hidden responsive-container responsive-container-constrained field__item">Newborn Breathing Conditions Research</h1> </div> <div class="language-switcher-language-url block block-language block-language-blocklanguage-content" role="navigation"> <div class="responsive-container responsive-container-constrained"><h2 class="visually-hidden" aria-label="Switch to Espanol">Language switcher</h2><ul class="links"><li hreflang="en" data-drupal-link-system-path="node/93427" class="is-active" aria-current="page"><a href="/research/newborn-breathing-conditions" class="language-link is-active" hreflang="en" data-drupal-link-system-path="node/93427" aria-current="page">English</a></li><li hreflang="es" data-drupal-link-system-path="node/93427"><a href="/es/investigaciones/afecciones-respiratorias-neonatales" class="language-link" hreflang="es" data-drupal-link-system-path="node/93427">Español</a></li></ul> </div> </div> <div class="block block-layout-builder block-field-blocknoderesearch-topicsfield-component-page-links"> <div class="responsive-container responsive-container-constrained"> <div class="component-lab-banner-links component-page-links component-page-links-theme-blue" id="component-page-links-holder"><span class="component-page-links-kicker">IN THIS ARTICLE</span> <ul id="component-page-links-ul"> </ul> <div id="component-page-links-more-button" class="component-page-links-more-button"><a class="component-page-links-more-button-a" href="javascript:void(0);">View More</a></div> <div id="component-page-links-less-button" class="component-page-links-less-button hidden"><a class="component-page-links-less-button-a" href="javascript:void(0);">View Less</a></div> </div> </div> </div> <div class="block block-layout-builder block-field-blocknoderesearch-topicsfield-health-topic-summary"> <div class="responsive-container responsive-container-constrained"> <div class="field field--name-field-health-topic-summary field--type-text-long field--label-hidden field__item"><p><span><span><span>As part of its broader commitment to research on <a href="https://www.nhlbi.nih.gov/science/lung-diseases" rel="noreferrer">lung diseases</a>, the NHLBI leads and supports research and programs on newborn breathing conditions. Our research has helped scientists and clinicians better understand the causes of breathing and lung problems in newborns. We continue to support research to help find new ways to prevent and treat these conditions. </span></span></span></p></div> </div> </div> <div class="block block-paragraph-blocks block-paragraph-fieldnodefield-component-quick-links0research-topics"> <div class="component-quick-links-block component-quick-links-theme-" > <div class="paragraph paragraph--type--component-qu paragraph--view-mode--default responsive-container responsive-container-constrained"> <div class="component-quick-links-container"> <div class="component-quick-links-title"> <div class="field field--name-field-component-quick-links-tit field--type-string field--label-hidden field__item">More on newborn breathing</div> </div> <div class="component-quick-links-buttons"> <div class="field field--name-field-component-quick-links-refe field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"><div class="paragraph paragraph--type--component-quick-links paragraph--view-mode--default"> <a href="https://www.nhlbi.nih.gov/health/newborn-breathing-conditions"> <div class="component-quick-link-container"> <div class="component-quick-link-icon"> <div class="field field--name-field-component-quick-link-icon field--type-image field--label-hidden field__item"> <img loading="lazy" src="/modules/custom/nhlbi_blazy/images/clear.png" width="32" height="32" alt="Illustration of a document with the red cross medical symbol" data-src="/sites/default/files/styles/component_quik/public/component_quick_links/2022-03/document-solid-blue1_1.png?itok=dJR4YxBV" class="b-lazy image-style-component-quik" /> </div> </div> <div class="component-quick-link-text">Patient Information</div> </div> </a> </div> </div> <div class="field__item"><div class="paragraph paragraph--type--component-quick-links paragraph--view-mode--default"> <a href="https://www.nhlbi.nih.gov/research/clinical-trials?f%5B0%5D=disease_or_condition_name%3ANewborn%20Breathing%20Conditions"> <div class="component-quick-link-container"> <div class="component-quick-link-icon"> <div class="field field--name-field-component-quick-link-icon field--type-image field--label-hidden field__item"> <img loading="lazy" src="/modules/custom/nhlbi_blazy/images/clear.png" width="32" height="32" alt="Illustration of a microscope" data-src="/sites/default/files/styles/component_quik/public/component_quick_links/2022-03/microscope-alt-solid-blue1_2.png?itok=srGUGMss" class="b-lazy image-style-component-quik" /> </div> </div> <div class="component-quick-link-text">Participate in a study</div> </div> </a> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="layout layout--onecol"> <div class="layout__region layout__region--content"> <div class="block block-layout-builder block-field-blocknoderesearch-topicsfield-component-sections"> <div class="field field--name-field-component-sections field--type-entity-reference-revisions field--label-hidden"> <div class='field__items'> <div class="paragraph component component-section component-theme-white component-section-theme-white component-section-node-theme- paragraph--type--component-section paragraph--view-mode--default"> <div class="responsive-container responsive-container-constrained"> <h2 class="field--name-field-component-section-titl component-section-section-title">NHLBI research that really made a difference</h2> <div class="field field--name-field-component-section-content field--type-text-long field--label-hidden clearfix field__item"><p>Ground-breaking research funded by the NHLBI has helped establish the standards of care for newborns with breathing and lung problems. Our research helped develop the use of corticosteroids to accelerate lung development in babies at risk for premature birth. We also funded studies developing the use of surfactant replacement therapy to improve breathing in premature newborns and the use of nitric oxide to treat pulmonary hypertension. These treatment methods continue to significantly improve the survival and long-term quality of life for premature newborns. Read about <a href="https://pubmed.ncbi.nlm.nih.gov/26842679/" rel="noreferrer">the study on the use of corticosteroids</a>.</p></div> </div> </div> <div class="paragraph component component-section component-theme-white component-section-theme-white component-section-node-theme- paragraph--type--component-section paragraph--view-mode--default"> <div class="responsive-container responsive-container-constrained"> <h2 class="field--name-field-component-section-titl component-section-section-title">Current research funded by the NHLBI</h2> <div class="field field--name-field-component-section-content field--type-text-long field--label-hidden clearfix field__item"><p>Our <a href="https://www.nhlbi.nih.gov/about/divisions/division-lung-diseases" rel="noreferrer">Division of Lung Diseases</a> and its <a href="https://www.nhlbi.nih.gov/about/divisions/division-lung-diseases/lung-biology-and-disease-branch" rel="noreferrer">Lung Biology and Disease Branch</a> fund research on breathing conditions in newborns.</p><p> <span data-langcode="en" data-entity-type="node" data-entity-uuid="12cf49da-88a7-43ba-882d-da98975d4bf0" data-embed-button="node" data-entity-embed-display="entity_reference:entity_reference_entity_view" data-entity-embed-display-settings="{"view_mode":"default"}" class="embedded-entity"> <article class="node node--type-callout node--promoted node--view-mode-callout-descriptive blue"> <div class="node__content"> <div class="component-callout-container component-callout-container-descriptive component-callout-container-descriptive-blue component-callout-container-descriptive-white callout-descriptive-no-image"> <div class="callout-descriptive"> <div class="callout-descriptive-text"> <div class="field field--name-field-kicker field--type-string field--label-hidden field__item">Research Funding</div> <div class="field field--name-field-callout-description field--type-text-long field--label-hidden field__item"> <p>Find <a href="https://www.nhlbi.nih.gov/grants-and-training/funding-opportunities-and-contacts/all-funding-opportunity-announcements" rel="noreferrer">funding opportunities</a> and <a href="https://www.nhlbi.nih.gov/grants-and-training/funding-opportunities/lung-developmental-biology-neonatal-pediatric-diseases" rel="noreferrer">program contacts</a> for respiratory failure research. </p> </div> </div> </div> </div> </div> </article> </span> </p><h3>Current research on preventing and treating bronchopulmonary dysplasia (BPD)</h3><ul><li>An <a href="https://reporter.nih.gov/search/31xpvCiSUU6yS5q9LYTNdA/project-details/10274808" rel="noreferrer">NHLBI-funded study on sildenafil (Viagra)</a> is investigating a safe starting dose for babies who develop <a href="https://www.nhlbi.nih.gov/health/pulmonary-hypertension" rel="noreferrer">pulmonary hypertension</a> as part of bronchopulmonary dysplasia (BPD), a lung disease of prematurity. The medicine is often used off-label by doctors in babies to treat pulmonary hypertension and this study will help to provide clinical data on an age-appropriate dosing strategy.</li><li>NHLBI funds a study about the effect of positive pressure ventilation to enhance lung growth in premature babies using animal models.</li><li>NHLBI-funded researchers are investigating the use of <a href="https://reporter.nih.gov/search/PkZvaEPJCEWY-4F_PBS6kw/project-details/10238056" rel="noreferrer">inhaled vitamin A</a> in animal models to prevent BPD by reducing lung damage. Vitamin A may improve lung development in newborns.</li><li>With support from the NHLBI, researchers are investigating the <a href="https://reporter.nih.gov/search/yGooJZ9KikCglN976M10ZQ/project-details/10133131" rel="noreferrer">use of magnetic resonance imaging (MRI)</a> and mathematical resolution of X-ray images to better understand lung problems that occur in newborns with BPD. Many imaging methods require sedation and can expose infants to radiation. New, cutting-edge MRI methods do not require either, and could provide images of the structure and function of the lungs that may help doctors diagnose and treat infants with BPD.</li><li>NHLBI-funded researchers are using ultra-short MRI techniques to image the lung and chest bones, including the rib cage, and correlate findings to lung volumes and capacities in the growing child.</li><li>With support from NHLBI, researchers are studying toddlers who were born premature and whose mothers received steroids in late pregnancy to assist with the child’s lung function and cognitive development. Similarly, premature babies who received steroids soon after birth are being studied for lung function and intellectual ability at school age.</li></ul><p>Find more NHLBI-funded studies on <a href="https://reporter.nih.gov/search/bR57TkAEH0er-s8e2xEQpQ/projects?projects=Active" rel="noreferrer">bronchopulmonary dysplasia</a> at NIH RePORTER. </p><p> <span data-langcode="en" data-entity-type="node" data-entity-uuid="2d7f49be-ce7c-4e4e-9eb8-dae2ebb7991a" data-embed-button="node" data-entity-embed-display="entity_reference:entity_reference_entity_view" data-entity-embed-display-settings="{"view_mode":"default"}" class="embedded-entity"> <article class="node node--type-callout node--promoted node--view-mode-callout-descriptive blue"> <div class="node__content"> <div class="component-callout-container component-callout-container-descriptive component-callout-container-descriptive-blue component-callout-container-descriptive-white callout-descriptive-no-image"> <div class="callout-descriptive"> <div class="callout-descriptive-text"> <div class="field field--name-field-kicker field--type-string field--label-hidden field__item">NHLBI in the Press</div> <div class="field field--name-field-callout-description field--type-text-long field--label-hidden field__item"> <p>Read more about <a href="https://www.nhlbi.nih.gov/news/2019/study-points-possible-cell-based-lung-therapy-help-premature-babies-breathe-easier" rel="noreferrer">a study that points to possible cell-based lung therapy to help premature babies breathe easier</a>.</p> </div> </div> </div> </div> </div> </article> </span> </p><h3>Current research on preventing and treating breathing problems related to premature birth</h3><ul><li>NHLBI-funded research is testing the use of <a href="https://reporter.nih.gov/search/PkZvaEPJCEWY-4F_PBS6kw/project-details/9779080" rel="noreferrer">therapeutic <em>in utero</em> gene editing called CRISPR-Cas9</a> to treat genetic disorders before birth that can lead to breathing issues in newborns. Babies who are born premature have less developed lungs and a deficiency of the cells that produce surfactant, which helps keep the lungs stable after birth and prevents them from collapsing. Without enough surfactant, infants struggle to breathe, a condition called <a href="https://nhlbi.nih.gov/research/newborn-breathing-conditions/respiratory" rel="noreferrer">respiratory distress syndrome (RDS)</a> of the newborn.</li><li>Other NHLBI-funded researchers are <a href="https://reporter.nih.gov/search/_OeRKJfniU-5JpkDcdd1cw/project-details/10252528" rel="noreferrer">developing synthetic lung surfactant</a> that would be lower in cost and more accessible to newborns with RDS across the globe.</li><li>NHLBI-funded researchers are developing a low-cost electrode that can generate nitric oxide, a portable option for a potent pulmonary hypertension treatment that can be used worldwide.</li><li>A study on <a href="https://reporter.nih.gov/search/yGooJZ9KikCglN976M10ZQ/project-details/10137685" rel="noreferrer">lung imaging software</a> may help better predict which newborns with breathing conditions are at risk for developing serious complications like BPD or lower respiratory tract infections. Researchers are using technology called Lung Aeration and Irregular opacities Radiological analyzer (LungAIR) and electronic health record data to reduce hospitalization time and lower rates of serious complications and death in newborns with breathing conditions.</li></ul><p>Find more NHLBI-funded studies on <a href="https://reporter.nih.gov/search/RugRabx6pUaarrly4KnIfw/projects" rel="noreferrer">breathing problems related to premature birth</a> at NIH RePORTER. </p><h3>Current research on the long-term effects of newborn breathing conditions</h3><ul><li>NHLBI-supported research aims to better understand <a href="https://reporter.nih.gov/search/dnCluqlsP0GqloSxw4HwYg/project-details/10363406" rel="noreferrer">why some babies with breathing conditions develop additional health problems</a> throughout their childhood, such as <a href="https://www.nhlbi.nih.gov/health/asthma" rel="noreferrer">asthma</a>, breathing abnormalities during sleep, and problems during development.</li><li> NHLBI-funded researchers are examining why some infants who need <a href="https://reporter.nih.gov/search/_OeRKJfniU-5JpkDcdd1cw/project-details/9962478" rel="noreferrer">continuous positive airway pressure (CPAP) treatment</a> develop medical problems like asthma and wheezing later in life. Researchers hope that this discovery will reveal promising targets to prevent unintended effects of CPAP treatment in newborns with breathing conditions.</li></ul><p>Find more NHLBI-funded studies on understanding the <a href="https://reporter.nih.gov/search/wFZ8M80T7Um-sivVGg52dQ/projects?projects=Active" rel="noreferrer">long-term effects of newborn breathing conditions</a> at NIH RePORTER. </p></div> </div> </div> <div class="paragraph component component-section component-theme-white component-section-theme-white component-section-node-theme- paragraph--type--component-section paragraph--view-mode--default"> <div class="responsive-container responsive-container-constrained"> <h2 class="field--name-field-component-section-titl component-section-section-title">Newborn breathing condition research labs at the NHLBI</h2> <div class="field field--name-field-component-section-desc field--type-text-long field--label-hidden clearfix field__item"><p>Our <a href="https://www.nhlbi.nih.gov/about/divisions/division-intramural-research" rel="noreferrer">Division of Intramural Research</a> and its <a href="https://www.nhlbi.nih.gov/about/divisions/division-intramural-research/pulmonary-branch" rel="noreferrer">Pulmonary Branch</a> include some of the investigators at NHLBI who are actively engaged in the study of newborn breathing conditions.</p></div> </div> </div> <div class="paragraph component component-section component-theme-white component-section-theme-white component-section-node-theme- paragraph--type--component-section paragraph--view-mode--default"> <div class="responsive-container responsive-container-constrained"> <h2 class="field--name-field-component-section-titl component-section-section-title">Related newborn breathing condition programs</h2> <div class="field field--name-field-component-section-content field--type-text-long field--label-hidden clearfix field__item"><ul><li>The NHLBI supports the <a href="https://www.nhlbi.nih.gov/node/83541" rel="noreferrer">Centers for Advanced Diagnostics and Experimental Therapeutics in Lung Diseases (CADET) program</a>. This program stimulated the development of new treatments for lung and breathing conditions, as well as sleep disorders. The first stage, CADET I, supported research on how lung diseases develop. The second stage, CADET II, funded research on new drugs.</li><li>The <a href="https://lungmap.net/" rel="noreferrer">Molecular Atlas of Lung Development Program</a> (LungMAP) is integrating many datasets to build a molecular map of the developing lung in both humans and mice. The program is helping advance lung research in part through its web-based data resource called BREATH, that allows users to access LungMAP data and findings. Learn more about <a href="https://www.nhlbi.nih.gov/news/2019/lungmap-nhlbi-project-breathes-life-first-depth-atlas-human-lung" rel="noreferrer">LungMAP: NHLBI project breathes life into first in-depth atlas of the human lung</a>. </li><li>The <a href="https://www.nhlbi.nih.gov/science/biologic-specimen-and-data-repository-information-coordinating-center-biolincc" rel="noreferrer">Biologic Specimen and Data Repository Information Coordinating Center (BioLINCC)</a> centralizes and integrates biospecimens and clinical data that were once stored in separate repositories. Researchers can find and request available resources on BioLINCC’s secure website, which maximizes the value of these resources and advances research in newborn breathing and lung conditions, among many others. </li></ul></div> </div> </div> </div> </div> </div> </div> </div> <div class="layout layout--onecol"> <div class="layout__region layout__region--content"> <div class="block block-layout-builder block-field-blocknoderesearch-topicsfield-component-explore-more-res"> <div class="field field--name-field-component-explore-more-res field--type-entity-reference-revisions field--label-hidden field__item"> <div class="paragraph component component-explore-more-research component-theme-light-blue component-explore-more-research-theme-light-blue component-explore-more-research-node-theme-blue paragraph--type--component-explore-more-research paragraph--view-mode--default"> <div class="responsive-container responsive-container-constrained"> <h2 class="field--name-field-component-section-titl component-explore-more-research-section-title">Explore more NHLBI research on newborn breathing conditions</h2> <div class="field field--name-field-component-section-desc field--type-text-long field--label-hidden field__item"><p>The sections above provide you with the highlights of NHLBI-supported research on newborn breathing conditions. You can explore the full list of NHLBI-funded studies on the <a href="https://reporter.nih.gov/" rel="noreferrer">NIH RePORTER</a>.</p></div> <div class="field field--name-field-component-section-content field--type-text-long field--label-hidden field__item"><p> <span data-entity-type="node" data-entity-uuid="769aefe7-3f20-47e6-b70b-6c680e0e61f7" data-embed-button="node" data-entity-embed-display="entity_reference:entity_reference_entity_view" data-entity-embed-display-settings="{"view_mode":"callout_plain_text"}" data-langcode="en" class="embedded-entity"> <article class="node node--type-callout node--promoted node--view-mode-callout-plain-text node--callout--plain-text--theme-blue"> <div class="node__content"> <div class="component-callout-container component-callout-plain-text component-callout-plain-text-theme-blue"> <div class="callout-plain-text"> <div class="field field--name-field-callout-description-notrim field--type-text-long field--label-hidden field__item"><p>To find more studies:</p><ul><li>Type your search words into the <strong>Quick Search</strong> box and press enter. </li><li>Check <strong>Active Projects</strong> if you want to find current research.</li><li>Select the <strong>Agencies</strong> arrow, then the <strong>NIH</strong> arrow, then check <strong>NHLBI</strong>.</li></ul><p>If you want to sort the projects by budget size <span style="font-family:"Calibri",sans-serif;font-size:11.0pt;line-height:107%;">—</span> from the biggest to the smallest <span style="font-family:"Calibri",sans-serif;font-size:11.0pt;line-height:107%;">—</span> click on the <strong>FY Total Cost by IC</strong> column heading.</p></div> </div> </div> </div> </article> </span> </p></div> </div> </div> </div> </div> </div> </div> <div class="layout layout--onecol"> <div class="layout__region layout__region--content"> <div class="block block-layout-builder block-field-blocknoderesearch-topicsfield-last-updated"> <div class="field field--name-field-last-updated 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