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(PDF) Detection and Reporting of Organisms Producing Extended-Spectrum β-Lactamases: Survey of Laboratories in Connecticut | Zygmunt Dembek - Academia.edu

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They are most common in Klebsiella spp. and Escherichia coli but are present in a" /> <title>(PDF) Detection and Reporting of Organisms Producing Extended-Spectrum β-Lactamases: Survey of Laboratories in Connecticut | Zygmunt Dembek - Academia.edu</title> <link rel="canonical" href="https://www.academia.edu/110665278/Detection_and_Reporting_of_Organisms_Producing_Extended_Spectrum_%CE%B2_Lactamases_Survey_of_Laboratories_in_Connecticut" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "single_work", 'action': "show", 'controller_action': 'single_work#show', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script> var $controller_name = 'single_work'; var $action_name = "show"; var $rails_env = 'production'; var $app_rev = '93b7474171e6a4b1bbf2c2315cd7570fbc58ca00'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.require = { config: function() { return function() {} } } </script> <script> window.Aedu = window.Aedu || {}; window.Aedu.hit_data = null; window.Aedu.serverRenderTime = new Date(1733268020000); window.Aedu.timeDifference = new Date().getTime() - 1733268020000; </script> <script type="application/ld+json">{"@context":"https://schema.org","@type":"ScholarlyArticle","abstract":"Extended-spectrum β-lactamases (ESBLs) are enzymes produced in some gram-negative bacilli that mediate resistance to extended-spectrum cephalosporins and aztreonam. They are most common in Klebsiella spp. and Escherichia coli but are present in a variety of Enterobacteriaceae . Resistance mediated by these enzymes can be difficult to detect depending on the antimicrobial agents tested. AmpC β-lactamases are related to the chromosomal enzymes of Enterobacter and Citrobacter spp. and also mediate resistance to extended-spectrum cephalosporins and aztreonam in addition to cephamycins, such as cefoxitin. Unlike ESBLs, however, AmpC β-lactamases are not inhibited by clavulanic acid or other similar compounds. To assess the abilities of various antimicrobial susceptibility testing methods to detect ESBLs, we sent three ESBL-producing organisms, one AmpC-producing organism, and a control strain that was susceptible to extended-spectrum cephalosporins to 38 laboratories in Connecticut for t...","author":[{"@context":"https://schema.org","@type":"Person","name":"Zygmunt Dembek"}],"contributor":[],"dateCreated":"2023-12-05","datePublished":"1999-01-01","headline":"Detection and Reporting of Organisms Producing Extended-Spectrum β-Lactamases: Survey of Laboratories in Connecticut","image":"https://attachments.academia-assets.com/108412238/thumbnails/1.jpg","inLanguage":"en","keywords":["Microbiology","Biology","Medicine","Clinical Microbiology","Biological Sciences","Humans","Escherichia coli","United States","Clinical","Cephalosporins","Connecticut","Laboratories","Microbial Sensitivity Tests","Cefotaxime","Aztreonam","Citrobacter","Beta Lactamases","Klebsiella pneumoniae","Enterobacter cloacae","Medical and Health Sciences"],"publication":"Journal of Clinical Microbiology","publisher":{"@context":"https://schema.org","@type":"Organization","name":"American Society for Microbiology"},"sourceOrganization":[{"@context":"https://schema.org","@type":"EducationalOrganization","name":null}],"thumbnailUrl":"https://attachments.academia-assets.com/108412238/thumbnails/1.jpg","url":"https://www.academia.edu/110665278/Detection_and_Reporting_of_Organisms_Producing_Extended_Spectrum_%CE%B2_Lactamases_Survey_of_Laboratories_in_Connecticut"}</script><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/single_work_page/loswp-102fa537001ba4d8dcd921ad9bd56c474abc201906ea4843e7e7efe9dfbf561d.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/body-8d679e925718b5e8e4b18e9a4fab37f7eaa99e43386459376559080ac8f2856a.css" /><link rel="stylesheet" media="all" 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They are most common in Klebsiella spp. and Escherichia coli but are present in a variety of Enterobacteriaceae . Resistance mediated by these enzymes can be difficult to detect depending on the antimicrobial agents tested. AmpC β-lactamases are related to the chromosomal enzymes of Enterobacter and Citrobacter spp. and also mediate resistance to extended-spectrum cephalosporins and aztreonam in addition to cephamycins, such as cefoxitin. Unlike ESBLs, however, AmpC β-lactamases are not inhibited by clavulanic acid or other similar compounds. To assess the abilities of various antimicrobial susceptibility testing methods to detect ESBLs, we sent three ESBL-producing organisms, one AmpC-producing organism, and a control strain that was susceptible to extended-spectrum cephalosporins to 38 laboratories in Connecticut for t...","publisher":"American Society for Microbiology","publication_date":"1999,,","publication_name":"Journal of Clinical Microbiology"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Detection and Reporting of Organisms Producing Extended-Spectrum β-Lactamases: Survey of Laboratories in Connecticut","broadcastable":false,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [269788713]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;swp-splash-paper-cover&quot;,&quot;attachmentId&quot;:108412238,&quot;attachmentType&quot;:&quot;pdf&quot;}"><img alt="First page of “Detection and Reporting of Organisms Producing Extended-Spectrum β-Lactamases: Survey of Laboratories in Connecticut”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/108412238/mini_magick20231207-1-d3fobc.png?1701992654" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/assets/single_work_splash/adobe.icon-574afd46eb6b03a77a153a647fb47e30546f9215c0ee6a25df597a779717f9ef.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Detection and Reporting of Organisms Producing Extended-Spectrum β-Lactamases: Survey of Laboratories in Connecticut</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="269788713" href="https://independent.academia.edu/ZDembek"><img alt="Profile image of Zygmunt Dembek" class="ds-work-card--author-avatar" src="https://0.academia-photos.com/269788713/120297110/109621602/s65_zygmunt.dembek.png" />Zygmunt Dembek</a></div><div class="ds-work-card--detail"><p class="ds-work-card--detail ds2-5-body-sm">1999, Journal of Clinical Microbiology</p></div><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">Extended-spectrum β-lactamases (ESBLs) are enzymes produced in some gram-negative bacilli that mediate resistance to extended-spectrum cephalosporins and aztreonam. They are most common in Klebsiella spp. and Escherichia coli but are present in a variety of Enterobacteriaceae . Resistance mediated by these enzymes can be difficult to detect depending on the antimicrobial agents tested. AmpC β-lactamases are related to the chromosomal enzymes of Enterobacter and Citrobacter spp. and also mediate resistance to extended-spectrum cephalosporins and aztreonam in addition to cephamycins, such as cefoxitin. Unlike ESBLs, however, AmpC β-lactamases are not inhibited by clavulanic acid or other similar compounds. To assess the abilities of various antimicrobial susceptibility testing methods to detect ESBLs, we sent three ESBL-producing organisms, one AmpC-producing organism, and a control strain that was susceptible to extended-spectrum cephalosporins to 38 laboratories in Connecticut for t...</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;continue-reading-button--work-card&quot;,&quot;attachmentId&quot;:108412238,&quot;attachmentType&quot;:&quot;pdf&quot;,&quot;workUrl&quot;:&quot;https://www.academia.edu/110665278/Detection_and_Reporting_of_Organisms_Producing_Extended_Spectrum_%CE%B2_Lactamases_Survey_of_Laboratories_in_Connecticut&quot;}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" 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href="https://www.academia.edu/8108541/Susceptibility_patterns_to_extended_spectrum_cephalosporins_among_Enterobacteriaceae_harbouring_extended_spectrum_lactamases_using_the_updated_Clinical_and_Laboratory_Standards_Institute_interpretive_criteria"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="109197174" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/109197174/Susceptibility_patterns_to_extended_spectrum_cephalosporins_among_Enterobacteriaceae_harbouring_extended_spectrum_%CE%B2_lactamases_using_the_updated_Clinical_and_Laboratory_Standards_Institute_interpretive_criteria">Susceptibility patterns to extended-spectrum cephalosporins among Enterobacteriaceae harbouring extended-spectrum β-lactamases using the updated Clinical and Laboratory Standards Institute interpretive criteria</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="10574860" href="https://independent.academia.edu/MARIAKIMOULI">MARIA KIMOULI</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Journal of Antimicrobial Agents, 2013</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;wsj-grid-card-download-pdf-modal&quot;,&quot;work_title&quot;:&quot;Susceptibility patterns to extended-spectrum cephalosporins among Enterobacteriaceae harbouring extended-spectrum β-lactamases using the updated Clinical and Laboratory Standards Institute interpretive criteria&quot;,&quot;attachmentId&quot;:107393317,&quot;attachmentType&quot;:&quot;pdf&quot;,&quot;work_url&quot;:&quot;https://www.academia.edu/109197174/Susceptibility_patterns_to_extended_spectrum_cephalosporins_among_Enterobacteriaceae_harbouring_extended_spectrum_%CE%B2_lactamases_using_the_updated_Clinical_and_Laboratory_Standards_Institute_interpretive_criteria&quot;,&quot;alternativeTracking&quot;:true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/109197174/Susceptibility_patterns_to_extended_spectrum_cephalosporins_among_Enterobacteriaceae_harbouring_extended_spectrum_%CE%B2_lactamases_using_the_updated_Clinical_and_Laboratory_Standards_Institute_interpretive_criteria"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="94041979" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/94041979/Comparison_of_different_phenotypic_assays_for_the_detection_of_extended_spectrum_%CE%B2_lactamase_production_by_inducible_AmpC_producing_Gram_negative_bacilli">Comparison of different phenotypic assays for the detection of extended-spectrum β-lactamase production by inducible AmpC-producing Gram-negative bacilli</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="251567558" href="https://independent.academia.edu/EliseWillems3">Elise Willems</a></div><p class="ds-related-work--metadata ds2-5-body-xs">European Journal of Clinical Microbiology &amp; Infectious Diseases, 2012</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;wsj-grid-card-download-pdf-modal&quot;,&quot;work_title&quot;:&quot;Comparison of different phenotypic assays for the detection of extended-spectrum β-lactamase production by inducible AmpC-producing Gram-negative bacilli&quot;,&quot;attachmentId&quot;:96612032,&quot;attachmentType&quot;:&quot;pdf&quot;,&quot;work_url&quot;:&quot;https://www.academia.edu/94041979/Comparison_of_different_phenotypic_assays_for_the_detection_of_extended_spectrum_%CE%B2_lactamase_production_by_inducible_AmpC_producing_Gram_negative_bacilli&quot;,&quot;alternativeTracking&quot;:true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/94041979/Comparison_of_different_phenotypic_assays_for_the_detection_of_extended_spectrum_%CE%B2_lactamase_production_by_inducible_AmpC_producing_Gram_negative_bacilli"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="32501056" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/32501056/Characterization_of_TEM_SHV_CTX_and_AmpC_type_beta_lactamases_from_Cephalosporin_Resistant_Escherichia_coli_Isolates_from_Northwest_of_Iran">Characterization of TEM-, SHV-, CTX-and AmpC-type beta-lactamases from Cephalosporin Resistant Escherichia coli Isolates from Northwest of Iran</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="57244893" href="https://tbzmed.academia.edu/MohammadAhangarzadehRezaee">Mohammad Ahangarzadeh Rezaee</a></div><p class="ds-related-work--abstract ds2-5-body-sm">Escherichia coli isolates that produce Extended-Spectrum â-Lactamase (ESBL) and AmpC â-lactamases not only cause treatment failure, but usually carry resistance genes for other antibiotics, which limits the choice of therapy. This study focused on the prevalence, detection and comparison of ESBL-type resistance genes (TEM, SHV, and CTX-M) with plasmid-mediated AmpC-producing genes (MOX, CIT, DHA) from E. coli isolates from Northwest of Iran. A total of 146 ceftazidime-resistance Escherichia coli clinical isolates were collected from hospitalized cases of urinary tract infection from Northwest of Iran. Phenotypic and genotypic examination by PCR was done for the presence of ESBL and AmpC genes by PCR. One hundred and twenty eight (87.8%) and 18 (12.3%) isolates were detected possibly as ESBLs and AmpC producers respectively. Of these, 135(92.5%) of the isolates harbored bla CTXM, 105(71.9%) bla TEM , 111(76%) bla SHV, 47(32.2%) CIT, 8(5.5%) MOX and 2 (1.4%) DHA gene. Findings of the present study indicates high rate of resistance to beta-lactam antibiotics due to CTX-M, TEM and SHV genes. Secondly, in 32% of AmpC isolates CIT genes was detected, which indicates high prevalence of this gene. This findings shows importance of developing local stewardship program for antibiotic consumption and screening isolates for the presence of ESBL and AmpC genes.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;wsj-grid-card-download-pdf-modal&quot;,&quot;work_title&quot;:&quot;Characterization of TEM-, SHV-, CTX-and AmpC-type beta-lactamases from Cephalosporin Resistant Escherichia coli Isolates from Northwest of Iran&quot;,&quot;attachmentId&quot;:52686912,&quot;attachmentType&quot;:&quot;pdf&quot;,&quot;work_url&quot;:&quot;https://www.academia.edu/32501056/Characterization_of_TEM_SHV_CTX_and_AmpC_type_beta_lactamases_from_Cephalosporin_Resistant_Escherichia_coli_Isolates_from_Northwest_of_Iran&quot;,&quot;alternativeTracking&quot;:true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/32501056/Characterization_of_TEM_SHV_CTX_and_AmpC_type_beta_lactamases_from_Cephalosporin_Resistant_Escherichia_coli_Isolates_from_Northwest_of_Iran"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="87929372" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/87929372/Phenotypic_detection_of_extended_spectrum_%CE%B2_lactamase_production_in_Enterobacteriaceae_review_and_bench_guide">Phenotypic detection of extended-spectrum β-lactamase production in Enterobacteriaceae: review and bench guide</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="91180700" href="https://salu.academia.edu/YasirAli">Yasir Ali</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Clinical Microbiology and Infection, 2008</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;wsj-grid-card-download-pdf-modal&quot;,&quot;work_title&quot;:&quot;Phenotypic detection of extended-spectrum β-lactamase production in Enterobacteriaceae: review and bench guide&quot;,&quot;attachmentId&quot;:92018998,&quot;attachmentType&quot;:&quot;pdf&quot;,&quot;work_url&quot;:&quot;https://www.academia.edu/87929372/Phenotypic_detection_of_extended_spectrum_%CE%B2_lactamase_production_in_Enterobacteriaceae_review_and_bench_guide&quot;,&quot;alternativeTracking&quot;:true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/87929372/Phenotypic_detection_of_extended_spectrum_%CE%B2_lactamase_production_in_Enterobacteriaceae_review_and_bench_guide"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;continue-reading-button--sticky-ctas&quot;,&quot;attachmentId&quot;:108412238,&quot;attachmentType&quot;:&quot;pdf&quot;,&quot;workUrl&quot;:null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;download-pdf-button--sticky-ctas&quot;,&quot;attachmentId&quot;:108412238,&quot;attachmentType&quot;:&quot;pdf&quot;,&quot;workUrl&quot;:null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_108412238" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. You can download the paper by clicking the button above.</p></div></div></div></div><div class="ds-sidebar--container js-work-sidebar"><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="0" data-entity-id="8222140" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/8222140/Characteristics_epidemiology_and_clinical_importance_of_emerging_strains_of_Gram_negative_bacilli_producing_extended_spectrum_%CE%B2_lactamases">Characteristics, epidemiology and clinical importance of emerging strains of Gram-negative bacilli producing extended-spectrum β-lactamases</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="16188562" href="https://qau.academia.edu/AamerAliShah">Aamer 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Laboratory&quot;,&quot;attachmentId&quot;:66397099,&quot;attachmentType&quot;:&quot;pdf&quot;,&quot;work_url&quot;:&quot;https://www.academia.edu/47152315/Outcome_of_Cephalosporin_Treatment_for_Serious_Infections_Due_to_Apparently_Susceptible_Organisms_Producing_Extended_Spectrum_b_Lactamases_Implications_for_the_Clinical_Microbiology_Laboratory&quot;,&quot;alternativeTracking&quot;:true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/47152315/Outcome_of_Cephalosporin_Treatment_for_Serious_Infections_Due_to_Apparently_Susceptible_Organisms_Producing_Extended_Spectrum_b_Lactamases_Implications_for_the_Clinical_Microbiology_Laboratory"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="2" data-entity-id="14760697" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/14760697/Occurrence_and_Phenotypic_Characteristics_of_Extended_Spectrum_Lactamases_among_Members_of_the_Family_Enterobacteriaceae_at_the_Tel_Aviv_Medical_Center_Israel_and_Evaluation_of_Diagnostic_Tests">Occurrence and Phenotypic Characteristics of Extended-Spectrum  -Lactamases among Members of the Family Enterobacteriaceae at the Tel-Aviv Medical Center (Israel) and Evaluation of Diagnostic Tests</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33727942" href="https://ariel.academia.edu/ShiriNavonvenezia">Shiri Navon-venezia</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Clinical Microbiology, 2003</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;wsj-grid-card-download-pdf-modal&quot;,&quot;work_title&quot;:&quot;Occurrence and Phenotypic Characteristics of Extended-Spectrum  -Lactamases among Members of the Family Enterobacteriaceae at the Tel-Aviv Medical Center (Israel) and Evaluation of Diagnostic Tests&quot;,&quot;attachmentId&quot;:43910510,&quot;attachmentType&quot;:&quot;pdf&quot;,&quot;work_url&quot;:&quot;https://www.academia.edu/14760697/Occurrence_and_Phenotypic_Characteristics_of_Extended_Spectrum_Lactamases_among_Members_of_the_Family_Enterobacteriaceae_at_the_Tel_Aviv_Medical_Center_Israel_and_Evaluation_of_Diagnostic_Tests&quot;,&quot;alternativeTracking&quot;:true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span 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Enterobacteriaceae&quot;,&quot;attachmentId&quot;:56662118,&quot;attachmentType&quot;:&quot;pdf&quot;,&quot;work_url&quot;:&quot;https://www.academia.edu/36720983/Phenotypic_and_Genotypic_Characterization_of_Extended_Spectrum_Beta_lactamases_Produced_by_Enterobacteriaceae&quot;,&quot;alternativeTracking&quot;:true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/36720983/Phenotypic_and_Genotypic_Characterization_of_Extended_Spectrum_Beta_lactamases_Produced_by_Enterobacteriaceae"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="4" 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href="https://independent.academia.edu/VictorYu15">Victor Yu</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Clinical Infectious Diseases, 1999</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;wsj-grid-card-download-pdf-modal&quot;,&quot;work_title&quot;:&quot;Editorial Response: Extended-Spectrum  -Lactamases: A Call for Improved Detection and Control&quot;,&quot;attachmentId&quot;:99669024,&quot;attachmentType&quot;:&quot;pdf&quot;,&quot;work_url&quot;:&quot;https://www.academia.edu/98271424/Editorial_Response_Extended_Spectrum_Lactamases_A_Call_for_Improved_Detection_and_Control&quot;,&quot;alternativeTracking&quot;:true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline 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