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class="suggested-user-card__user-info__subheader ds2-5-body-xs">Universit茅 de Strasbourg</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://vub.academia.edu/NayemaVandenHoute"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://vub.academia.edu/NayemaVandenHoute">Nayema Van den Houte</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Vrije Universiteit Brussel</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://unisalento.academia.edu/MarcelloGuido"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://unisalento.academia.edu/MarcelloGuido">Marcello Guido</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">University of Salento</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://independent.academia.edu/HafezW"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://independent.academia.edu/HafezW">Wael Hafez</a></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://uot.academia.edu/MediterrJPharmPharmSci"><img class="profile-avatar u-positionAbsolute" alt="Mediterr J Pharm Pharm Sci" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/229092986/85803633/74458158/s200_mediterr_j_pharm.pharm_sci.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://uot.academia.edu/MediterrJPharmPharmSci">Mediterr J Pharm Pharm Sci</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Universty Of Tripoli</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://independent.academia.edu/MauroPagani6"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a 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class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://independent.academia.edu/GiorgioTiecco">Giorgio Tiecco</a></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://uqu.academia.edu/WesamNasif"><img class="profile-avatar u-positionAbsolute" alt="Wesam Nasif" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/46232749/12238820/14938921/s200_wesam.nasif.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://uqu.academia.edu/WesamNasif">Wesam Nasif</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Umm Al-Qura University, Makkah, Saudi Arabia</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://independent.academia.edu/PYOKOGAWATERAOKA"><img class="profile-avatar u-positionAbsolute" alt="PATRICIA YOKOGAWA TERAOKA" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/232245077/88456721/77153819/s200_patricia.yokogawa_teraoka.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://independent.academia.edu/PYOKOGAWATERAOKA">PATRICIA YOKOGAWA TERAOKA</a></div></div></ul></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="160895526" href="https://www.academia.edu/Documents/in/Biology"><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://independent.academia.edu/AliElRoz","location":"/AliElRoz","scheme":"https","host":"independent.academia.edu","port":null,"pathname":"/AliElRoz","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Biology"]}" data-trace="false" data-dom-id="Pill-react-component-19599cd1-f2d7-42f7-ac59-8437ce4e9c7b"></div> <div id="Pill-react-component-19599cd1-f2d7-42f7-ac59-8437ce4e9c7b"></div> </a></div></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Ali El Roz</h3></div><div class="js-work-strip profile--work_container" data-work-id="102985395"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/102985395/Risk_Markers_of_COVID_19_a_Study_from_South_Lebanon"><img alt="Research paper thumbnail of Risk Markers of COVID-19, a Study from South-Lebanon" class="work-thumbnail" src="https://attachments.academia-assets.com/103112281/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/102985395/Risk_Markers_of_COVID_19_a_Study_from_South_Lebanon">Risk Markers of COVID-19, a Study from South-Lebanon</a></div><div class="wp-workCard_item"><span>COVID</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: COVID-19, caused by the novel coronavirus SARS-CoV-2, was declared by WHO in early 20...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: COVID-19, caused by the novel coronavirus SARS-CoV-2, was declared by WHO in early 2020 as a worldwide pandemic. Several known risk markers are associated with COVID-19 morbidity and mortality, including age, gender, and diseases, such as hypertension, diabetes, and chronic cardiovascular diseases. Recent studies have shown an association between COVID-19 infection and the ABO blood groups. Objective: To assess the prevalence of SARS-CoV-2 among suspected COVID-19 patients as well as the risk markers for COVID-19 associated with ABO blood group, Rhesus factor, and patient鈥檚 address during the past year. Methods: 69,019 nasopharyngeal swab samples were collected and analyzed by reverse transcription polymerase chain reaction technique for the detection of SARS-CoV-2 in patients attending a tertiary health care center in South Lebanon during the period between August 2020 and July 2021. Results: Among all tested subjects, the prevalence of SARS-CoV-2 infection was 19.2% (9...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="283da7f83fb9364028d0cee6acfb9a13" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":103112281,"asset_id":102985395,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/103112281/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="102985395"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="102985395"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 102985395; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="102111742"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/102111742/Antiproliferative_and_proapoptotic_effects_of_histone_deacetylase_inhibitors_on_gastrointestinal_neuroendocrine_tumor_cells"><img alt="Research paper thumbnail of Antiproliferative and proapoptotic effects of histone deacetylase inhibitors on gastrointestinal neuroendocrine tumor cells" class="work-thumbnail" src="https://attachments.academia-assets.com/102462512/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/102111742/Antiproliferative_and_proapoptotic_effects_of_histone_deacetylase_inhibitors_on_gastrointestinal_neuroendocrine_tumor_cells">Antiproliferative and proapoptotic effects of histone deacetylase inhibitors on gastrointestinal neuroendocrine tumor cells</a></div><div class="wp-workCard_item"><span>Endocrine-Related Cancer</span><span>, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Treatment options of advanced neuroendocrine tumors (NETs) are unsatisfactory. Hence, innovative ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Treatment options of advanced neuroendocrine tumors (NETs) are unsatisfactory. Hence, innovative therapeutic approaches are urgently needed. Inhibition of histone deacetylases (HDACs) is a promising new approach in cancer therapy. While several HDAC inhibitors have already entered clinical trials, the effect of HDAC inhibition on NET has not been investigated. Therefore, we evaluated the antineoplastic effects of three different HDAC inhibitors, trichostatin A (TSA), sodium butyrate (NaB), and MS-275, on growth and apoptosis of the gastrointestinal NET cell lines CM and BON. We could demonstrate that HDAC inhibition dose-dependently inhibited proliferation of both cell lines with IC50 values varying from the millimolar (NaB) to the micromolar (MS-275) and the nanomolar range (TSA). Moreover, HDAC inhibition potently induced apoptosis, which was accompanied by DNA-fragmentation, an up to 12-fold caspase-3 activation and downregulated Bcl-2 expression. Furthermore, HDAC inhibition res...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5d066a6f71432324102244e6a957107b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":102462512,"asset_id":102111742,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/102462512/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="102111742"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="102111742"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 102111742; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5d066a6f71432324102244e6a957107b" } } $('.js-work-strip[data-work-id=102111742]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":102111742,"title":"Antiproliferative and proapoptotic effects of histone deacetylase inhibitors on gastrointestinal neuroendocrine tumor cells","internal_url":"https://www.academia.edu/102111742/Antiproliferative_and_proapoptotic_effects_of_histone_deacetylase_inhibitors_on_gastrointestinal_neuroendocrine_tumor_cells","owner_id":160895526,"coauthors_can_edit":true,"owner":{"id":160895526,"first_name":"Ali","middle_initials":null,"last_name":"El Roz","page_name":"AliElRoz","domain_name":"independent","created_at":"2020-06-11T23:06:32.079-07:00","display_name":"Ali El Roz","url":"https://independent.academia.edu/AliElRoz"},"attachments":[{"id":102462512,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/102462512/thumbnails/1.jpg","file_name":"0131237.pdf","download_url":"https://www.academia.edu/attachments/102462512/download_file","bulk_download_file_name":"Antiproliferative_and_proapoptotic_effec.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/102462512/0131237-libre.pdf?1684672039=\u0026response-content-disposition=attachment%3B+filename%3DAntiproliferative_and_proapoptotic_effec.pdf\u0026Expires=1740530416\u0026Signature=OWPB09yGtqhmLwpdJmpw0xl1yv5YroSrcmFhE3-4xLQEWuTYNvW6LaqbNcX~hsfNtoE58XeAei-fKr-tiNIL9fQCNTWyvwPMRYj3R5CrYV6HurEe4gYjLwjMJ6XjWX7qjo33ybShnDXEyKXLY89UV0vy5UPUE6WbWw11UtJG8oIrMfQajhVCCBxpZXmHtUWVBW4xum85P4uBFgPt4ml6B62g17g4q3QuZs41z3l-RVT4eiipGfKQg70mpXW3cJulfUhUO512B3DGRfBEDp05-rY1KjM81Yt~cPnjoLgtbu0V9l0Cpp8JzVqc~9r4CrPf~CUsKiHeHFTxw-lrgxVGNQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":102462513,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/102462513/thumbnails/1.jpg","file_name":"0131237.pdf","download_url":"https://www.academia.edu/attachments/102462513/download_file","bulk_download_file_name":"Antiproliferative_and_proapoptotic_effec.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/102462513/0131237-libre.pdf?1684672030=\u0026response-content-disposition=attachment%3B+filename%3DAntiproliferative_and_proapoptotic_effec.pdf\u0026Expires=1740530416\u0026Signature=VMXjprBkgcoE9VifsysBtp4vjcDvj9cLv3ox5AcXlYWg-aZQFA~Ir5A6eJ59iYPOs-QW629VEBQvalcLHFz21ZWskWJBeAfisE9aNSRlA9dp4z-A7ETGJs-P-pN0TmdX3z6ZByyNtG8hxKiuc9dV~95BWGvdLBN3jeS7dHsC0qdWH67iise8MSHcG85udHecw5H0EjFOJa0JLc609JMmBM~k25xEf8gayJViUf-8UpwXBBCx5Fq4MTgp1Bxfytz2z-9xWP4RhAqxT3l5oHB8F7YOwjHcgJDPGBFHrufy5bCL2RynQuQ7euMzrUO7fgq-hW0a9lQIF~KCNPcyGVWHXw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="102111740"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/102111740/The_emergence_of_SARS_CoV_2_variant_s_and_its_impact_on_the_prevalence_of_COVID_19_cases_in_Nabatieh_region_Lebanon"><img alt="Research paper thumbnail of The emergence of SARS-CoV-2 variant(s) and its impact on the prevalence of COVID-19 cases in Nabatieh region, Lebanon" class="work-thumbnail" src="https://attachments.academia-assets.com/102462535/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/102111740/The_emergence_of_SARS_CoV_2_variant_s_and_its_impact_on_the_prevalence_of_COVID_19_cases_in_Nabatieh_region_Lebanon">The emergence of SARS-CoV-2 variant(s) and its impact on the prevalence of COVID-19 cases in Nabatieh region, Lebanon</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">BackgroundAn outbreak of an unknown respiratory illness caused by a novel corona-virus, SARS-CoV-...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">BackgroundAn outbreak of an unknown respiratory illness caused by a novel corona-virus, SARS-CoV-2, emerged in the city of Wuhan in Hubei province, China, in December 2019 and was referred to as coronavirus disease-2019 (COVID-19). Soon after, it was declared as a global pandemic by the World Health Organization (WHO) in March 2020. SARS-CoV-2 mainly infects the respiratory tract with different outcomes ranging from asymptomatic infection to severe critical illness leading to death. Different SARS-CoV-2 variants are emerging of which three have raised concerns worldwide due to their high transmissibility among populations.ObjectiveTo study the prevalence of COVID-19 in the region of Nabatieh - South Lebanon during the past year and assess the presence of SARS-CoV-2 variants and their effect on the spread of infection during times of lock-down. Methods: In our study, 37,474 nasopharyngeal swab samples were collected and analyzed for the detection of SARS-CoV-2 virus in suspected pati...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ce6e8de13d154f398a9ad0a9ad2e0592" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":102462535,"asset_id":102111740,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/102462535/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="102111740"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="102111740"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 102111740; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=102111740]").text(description); $(".js-view-count[data-work-id=102111740]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 102111740; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='102111740']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ce6e8de13d154f398a9ad0a9ad2e0592" } } $('.js-work-strip[data-work-id=102111740]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":102111740,"title":"The emergence of SARS-CoV-2 variant(s) and its impact on the prevalence of COVID-19 cases in Nabatieh region, Lebanon","internal_url":"https://www.academia.edu/102111740/The_emergence_of_SARS_CoV_2_variant_s_and_its_impact_on_the_prevalence_of_COVID_19_cases_in_Nabatieh_region_Lebanon","owner_id":160895526,"coauthors_can_edit":true,"owner":{"id":160895526,"first_name":"Ali","middle_initials":null,"last_name":"El Roz","page_name":"AliElRoz","domain_name":"independent","created_at":"2020-06-11T23:06:32.079-07:00","display_name":"Ali El Roz","url":"https://independent.academia.edu/AliElRoz"},"attachments":[{"id":102462535,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/102462535/thumbnails/1.jpg","file_name":"2021.04.08.21255005.full.pdf","download_url":"https://www.academia.edu/attachments/102462535/download_file","bulk_download_file_name":"The_emergence_of_SARS_CoV_2_variant_s_an.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/102462535/2021.04.08.21255005.full-libre.pdf?1684672022=\u0026response-content-disposition=attachment%3B+filename%3DThe_emergence_of_SARS_CoV_2_variant_s_an.pdf\u0026Expires=1740574124\u0026Signature=Y8tahR1v0mTKzup-m3U0QT84ylHGaR0pqMlxsYhcqGXoJQKv18TcQjYGkiILk2dGHMKqtOY2pckG1JwJroYUVEb9Hq3RqaIA-h0jlukm0cMHRRcLfF~iCu0ncSIAjWJP5vH-xe8JPRsp8OHrAjMYM7qbmReVNpI-t-tEFKYfEc6JpZ4~xIYyqpLiwdlx5trT3emUa9oMLX14lDpwK~QBEf4egfXqSnjdUx9srKKcv9lFueE5oBk0ec-2s1z-wS1lMmzTdlRqgZ6jLqqc8r5XnF2-UVnwRVyGQIY-w2VDsmGq76M5rkgPRN9BQwO35566XYYl4025gPBAq1pVxzEslA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="99207961"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/99207961/Neuroblastoma_chemotherapy_can_be_augmented_by_immunotargeting_O_acetyl_GD2_tumor_associated_ganglioside"><img alt="Research paper thumbnail of Neuroblastoma chemotherapy can be augmented by immunotargeting O-acetyl-GD2 tumor-associated ganglioside" class="work-thumbnail" src="https://attachments.academia-assets.com/100357810/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/99207961/Neuroblastoma_chemotherapy_can_be_augmented_by_immunotargeting_O_acetyl_GD2_tumor_associated_ganglioside">Neuroblastoma chemotherapy can be augmented by immunotargeting O-acetyl-GD2 tumor-associated ganglioside</a></div><div class="wp-workCard_item"><span>OncoImmunology</span><span>, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Despite recent advances in high-risk neuroblastoma therapy, the prognosis for patients remains po...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Despite recent advances in high-risk neuroblastoma therapy, the prognosis for patients remains poor. In addition, many patients suffer from complications related to available therapies that are highly detrimental to their quality of life. New treatment modalities are, thus, urgently needed to further improve the efficacy and reduce the toxicity of existing therapies. Since antibodies specific for O-acetyl GD2 ganglioside display pro-apoptotic activity against neuroblastoma cells, we hypothesized that combination of immunotherapy could enhance tumor efficacy of neuroblastoma chemotherapy. We demonstrate here that combination of anti-O-acetyl GD2 monoclonal antibody 8B6 with topotecan synergistically inhibited neuroblastoma cell proliferation, as shown by the combination index values. Mechanistically, we evidence that mAb 8B6 induced plasma cell membrane lesions, consistent with oncosis. Neuroblastoma tumour cells treated with mAb 8B6 indeed showed an increased uptake of topotecan by the tumor cells and a more profound tumor cell death evidenced by increased caspase-3 activation. We also found that the combination with topotecan plus monoclonal antibody 8B6 showed a more potent anti-tumor efficacy in vivo than either agent alone. Importantly, we used low-doses of topotecan with no noticeable side effect. Our data suggest that chemo-immunotherapy combinations may improve the clinical efficacy and safety profile of current chemotherapeutic modalities of neuroblastoma.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8c4556c8a89505ccf4992c34b7994f67" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":100357810,"asset_id":99207961,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/100357810/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="99207961"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="99207961"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 99207961; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=99207961]").text(description); $(".js-view-count[data-work-id=99207961]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 99207961; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='99207961']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8c4556c8a89505ccf4992c34b7994f67" } } $('.js-work-strip[data-work-id=99207961]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":99207961,"title":"Neuroblastoma chemotherapy can be augmented by immunotargeting O-acetyl-GD2 tumor-associated ganglioside","internal_url":"https://www.academia.edu/99207961/Neuroblastoma_chemotherapy_can_be_augmented_by_immunotargeting_O_acetyl_GD2_tumor_associated_ganglioside","owner_id":160895526,"coauthors_can_edit":true,"owner":{"id":160895526,"first_name":"Ali","middle_initials":null,"last_name":"El Roz","page_name":"AliElRoz","domain_name":"independent","created_at":"2020-06-11T23:06:32.079-07:00","display_name":"Ali El Roz","url":"https://independent.academia.edu/AliElRoz"},"attachments":[{"id":100357810,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/100357810/thumbnails/1.jpg","file_name":"pmc5739551.pdf","download_url":"https://www.academia.edu/attachments/100357810/download_file","bulk_download_file_name":"Neuroblastoma_chemotherapy_can_be_augmen.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/100357810/pmc5739551-libre.pdf?1679988740=\u0026response-content-disposition=attachment%3B+filename%3DNeuroblastoma_chemotherapy_can_be_augmen.pdf\u0026Expires=1740574124\u0026Signature=bi0ZeHL58s6iK~gW83NvcrbtLyKM5k4Tsdg4fWyg60OfLjLVMONoX3LllQ0LB9c~ig73qQtF6RdLNAUFQndFC0-ae9ULoqenpabIeOCR-9Q-B~f4bj9WDmHLonhKV~TH0cUF7mmd1Ppe~pcd6hA5XQe~29mHj43VzoxK-6-ImAVh3z4VcA8PgTNoLgxSRlaVOcFhnknxlJfuSvCa24Q2j-n2pyzUgw5gfR4RSTPE1Ka3BKYxDzLT8nVaknZIyHgVCMESDisfK3IbYmsWVpdKKj48~FH22gItopGnMaTAuIxKIR3Hs5F6K6zS6fyPMf8oP1UnTc4B5xdT3Dn~qDWgQg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="99207957"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/99207957/Prevalence_of_Campylobacter_spp_in_broilers_in_North_Lebanon"><img alt="Research paper thumbnail of Prevalence of Campylobacter spp. in broilers in North Lebanon" class="work-thumbnail" src="https://attachments.academia-assets.com/100357765/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/99207957/Prevalence_of_Campylobacter_spp_in_broilers_in_North_Lebanon">Prevalence of Campylobacter spp. in broilers in North Lebanon</a></div><div class="wp-workCard_item"><span>Veterinary World</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background and Aim: Great attention has been given recently to the prevalence of different Campyl...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background and Aim: Great attention has been given recently to the prevalence of different Campylobacter spp. in poultry since the latter are considered the major contributing reservoir of human campylobacteriosis. In Lebanon, the occurrence of campylobacteriosis in humans is high. The aim of our first-of-its-kind study in the country was to estimate the prevalence of Campylobacter spp. in broilers from a convenient sample of farms in North Lebanon. Materials and Methods: One hundred twenty-five fecal samples were collected from 25 broiler farms, which were selected, examined, and classified according to their biosecurity level and rearing system. All samples were subjected to qualitative microbiological culture testing and polymerase chain reaction (PCR) assays to detect Campylobacter spp. Results: Despite the reported use of antibiotics, cell culture and PCR were positive for 44% and 88%, respectively. This implies that this bacterium is resistant to antibiotics used on the farms....</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="609d5626dadb110b9fce2b74b37e0dc7" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":100357765,"asset_id":99207957,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/100357765/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="99207957"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="99207957"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 99207957; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="86939947"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/86939947/Risk_Markers_of_COVID_19_a_Study_from_South_Lebanon"><img alt="Research paper thumbnail of Risk Markers of COVID-19, a Study from South-Lebanon" class="work-thumbnail" src="https://attachments.academia-assets.com/91284386/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/86939947/Risk_Markers_of_COVID_19_a_Study_from_South_Lebanon">Risk Markers of COVID-19, a Study from South-Lebanon</a></div><div class="wp-workCard_item"><span>COVID</span><span>, Jun 27, 2022</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This article is an open access article distributed under the terms and conditions of the Creative...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="452602b6c1f93793c79f18895f3f88ab" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91284386,"asset_id":86939947,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91284386/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="86939947"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="86939947"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 86939947; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73514889"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73514889/Antimicrobial_Susceptibilities_and_Laboratory_Profiles_of_Escherichia_coli_Klebsiella_pneumoniae_and_Proteus_mirabilis_Isolates_as_Agents_of_Urinary_Tract_Infection_in_Lebanon_Paving_the_Way_for_Better_Diagnostics"><img alt="Research paper thumbnail of Antimicrobial Susceptibilities and Laboratory Profiles of Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis Isolates as Agents of Urinary Tract Infection in Lebanon: Paving the Way for Better Diagnostics" class="work-thumbnail" src="https://attachments.academia-assets.com/82008260/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73514889/Antimicrobial_Susceptibilities_and_Laboratory_Profiles_of_Escherichia_coli_Klebsiella_pneumoniae_and_Proteus_mirabilis_Isolates_as_Agents_of_Urinary_Tract_Infection_in_Lebanon_Paving_the_Way_for_Better_Diagnostics">Antimicrobial Susceptibilities and Laboratory Profiles of Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis Isolates as Agents of Urinary Tract Infection in Lebanon: Paving the Way for Better Diagnostics</a></div><div class="wp-workCard_item"><span>Medical Sciences</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Urinary tract infections (UTIs) are major healthcare problems that are usually treate...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Urinary tract infections (UTIs) are major healthcare problems that are usually treated empirically. However, antimicrobial resistance has been increasing across many settings. This study aims to elucidate the antibiotic resistance profiles of three common uropathogens, Escherichia coli (E. coli), Klebsiella pneumoniae (K. pneumoniae), and Proteus mirabilis (P. mirabilis) and compare between extended spectrum beta-lactamase (ESBL) and non-ESBL strains among Lebanese patients. Methods: This retrospective study was conducted at multiple tertiary healthcare centers in South Lebanon, between January and September 2017, including 551 patients of all age groups. Demographic, clinical, and laboratory data of patients were collected and analyzed statistically. Results: The prevalence of UTI in Lebanon was highest in adults between 19 and 64 years (44%). E. coli was the predominant uropathogenic organism (67.1%) followed by K. pneumoniae (10%) and P. mirabilis (3.7%). ESBL represe...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="36c247a97e06766373bdf82719793176" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":82008260,"asset_id":73514889,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/82008260/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73514889"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73514889"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73514889; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73514888"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/73514888/R%C3%A9cepteur_nucl%C3%A9aire_LXR_et_cancer_du_sein_coop%C3%A9ration_avec_les_macrophages_%C3%A9tudes_in_vitro_sur_les_mod%C3%A8les_MCF_7_et_THP_1"><img alt="Research paper thumbnail of R茅cepteur nucl茅aire LXR et cancer du sein : coop茅ration avec les macrophages : 茅tudes in vitro sur les mod猫les MCF-7 et THP-1" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/73514888/R%C3%A9cepteur_nucl%C3%A9aire_LXR_et_cancer_du_sein_coop%C3%A9ration_avec_les_macrophages_%C3%A9tudes_in_vitro_sur_les_mod%C3%A8les_MCF_7_et_THP_1">R茅cepteur nucl茅aire LXR et cancer du sein : coop茅ration avec les macrophages : 茅tudes in vitro sur les mod猫les MCF-7 et THP-1</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Les nutriments lipidiques peuvent intervenir dans la modulation des cancers en interagissant avec...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Les nutriments lipidiques peuvent intervenir dans la modulation des cancers en interagissant avec leurs recepteurs nucleaires. Parmi ces recepteurs, nous avons etudie le role du facteur nucleaire Liver X Receptor (LXR) dans un modele cellulaire de cancer du sein (MCF-7). LXR joue un role essentiel dans l&#39;homeostasie lipidique et notamment dans le transport inverse du cholesterol, permettant le retour de ce lipide des tissus peripheriques vers le foie. D&#39;autre part, certains isomeres conjugues de l&#39;acide linoleique (CLA) presents dans les aliments comme les produits laitiers et la viande des ruminants, et dont le pouvoir anti-tumoral est bien documente, ont recemment ete presentes comme activateurs potentiels de LXR. Nos travaux ont permis de confirmer l&#39;importance de l&#39;activation de la voie LXR par un agoniste synthetique (T0901317) et sterolique [22(R)-HC] et par l&#39;isomere t9,t11-CLA pour inhiber la proliferation cellulaire et induire l&#39;apoptose dans les...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73514888"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73514888"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73514888; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73514888]").text(description); $(".js-view-count[data-work-id=73514888]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73514888; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73514888']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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</script> <div class="js-work-strip profile--work_container" data-work-id="73514887"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73514887/The_Emergence_of_SARS_CoV_2_Variant_s_and_Its_Impact_on_the_Prevalence_of_COVID_19_Cases_in_the_Nabatieh_Region_Lebanon"><img alt="Research paper thumbnail of The Emergence of SARS-CoV-2 Variant(s) and Its Impact on the Prevalence of COVID-19 Cases in the Nabatieh Region, Lebanon" class="work-thumbnail" src="https://attachments.academia-assets.com/82008241/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73514887/The_Emergence_of_SARS_CoV_2_Variant_s_and_Its_Impact_on_the_Prevalence_of_COVID_19_Cases_in_the_Nabatieh_Region_Lebanon">The Emergence of SARS-CoV-2 Variant(s) and Its Impact on the Prevalence of COVID-19 Cases in the Nabatieh Region, Lebanon</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: An outbreak of an unknown respiratory illness caused by a novel coronavirus, SARS-CoV...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: An outbreak of an unknown respiratory illness caused by a novel coronavirus, SARS-CoV-2, emerged in the city of Wuhan in Hubei Province, China, in December 2019 and was referred to as coronavirus disease-2019 (COVID-19). Soon after, it was declared as a global pandemic by the World Health Organization (WHO) in March 2020. SARS-CoV-2 mainly infects the respiratory tract with different outcomes ranging from asymptomatic infection to severe critical illness leading to death. Different SARS-CoV-2 variants are emerging of which three have raised concerns worldwide due to their high transmissibility among populations. Objective: To study the prevalence of COVID-19 in the region of Nabatieh-South Lebanon during the past year and assess the presence of SARS-CoV-2 variants and their effect on the spread of infection during times of lockdown. Methods: In our study, 37,474 nasopharyngeal swab samples were collected and analyzed for the detection of SARS-CoV-2 virus in suspected pat...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a0adbac665c06e3ddb1b54592a789c40" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":82008241,"asset_id":73514887,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/82008241/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73514887"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73514887"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73514887; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a0adbac665c06e3ddb1b54592a789c40" } } $('.js-work-strip[data-work-id=73514887]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73514887,"title":"The Emergence of SARS-CoV-2 Variant(s) and Its Impact on the Prevalence of COVID-19 Cases in the Nabatieh Region, Lebanon","internal_url":"https://www.academia.edu/73514887/The_Emergence_of_SARS_CoV_2_Variant_s_and_Its_Impact_on_the_Prevalence_of_COVID_19_Cases_in_the_Nabatieh_Region_Lebanon","owner_id":160895526,"coauthors_can_edit":true,"owner":{"id":160895526,"first_name":"Ali","middle_initials":null,"last_name":"El Roz","page_name":"AliElRoz","domain_name":"independent","created_at":"2020-06-11T23:06:32.079-07:00","display_name":"Ali El Roz","url":"https://independent.academia.edu/AliElRoz"},"attachments":[{"id":82008241,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/82008241/thumbnails/1.jpg","file_name":"medsci-09-00040.pdf","download_url":"https://www.academia.edu/attachments/82008241/download_file","bulk_download_file_name":"The_Emergence_of_SARS_CoV_2_Variant_s_an.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/82008241/medsci-09-00040-libre.pdf?1646983275=\u0026response-content-disposition=attachment%3B+filename%3DThe_Emergence_of_SARS_CoV_2_Variant_s_an.pdf\u0026Expires=1740530416\u0026Signature=LM-v9OnNvSMIQruIt9gt9ipKFUcTL5WPeyh2-yx9ZseHRUpBcIWCpO1WUyI8M5u3U87c4MyzeF5qIh7j199m7r2Db0z80DDjnlixPCI7kLlNlh7NAH6fKni6X88kczOWhru9B1uvScxhkFKDWRNSDcabKie3IWMsYiWU9CqdN8JEgRCrAVreOqavKfb7KzntrZYYDRtPbx2mr0GktsuuNYH6c9xeXfrprOU0DB~if6wwinBxl57P1d2C5tWU6tVMjfNBnEYz6hOpwJrMuU7Z5mt9DBgGOnYG8EZ3OKS-jMdAtWumNuV0Bgso52x9WQFXzeu-9Ew7N1KROc~bozdB9g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":82008240,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/82008240/thumbnails/1.jpg","file_name":"medsci-09-00040.pdf","download_url":"https://www.academia.edu/attachments/82008240/download_file","bulk_download_file_name":"The_Emergence_of_SARS_CoV_2_Variant_s_an.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/82008240/medsci-09-00040-libre.pdf?1646983275=\u0026response-content-disposition=attachment%3B+filename%3DThe_Emergence_of_SARS_CoV_2_Variant_s_an.pdf\u0026Expires=1740530416\u0026Signature=SrUozSD5wjnFB8rYhFoBjuLIcyUN03k3vUTyQt79o9kIbEOWciJAX-5gAgbIoucv7pKSYrmXACMeqVzWha5coarOnGlrARuj0KKg55konOHxdp27yje1wVWPJ8VP~GaCmjnq9cD5Lx71w54qpRXmYRxe1RiKiEIhuilVuiO2oGIqqstyUxCPn6f-aCwAr3pWRpIJErmi0otoikP8ic9pA8TH2Q4z~Mr5p~qVqNngUHEOAIo4jve~glLA3yYMc57VegrXtKhQljMpAMJawjqVSb2GyT3vkwSiAXoXERIR0UdKcHNZlXvIjSS1eymet6Ob8bHwhbwDmtmh2-dPLhS6zA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73514886"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73514886/Prevalence_Laboratory_Findings_and_Clinical_Characteristics_of_Campylobacteriosis_Agents_among_Hospitalized_Children_with_Acute_Gastroenteritis_in_Lebanon"><img alt="Research paper thumbnail of Prevalence, Laboratory Findings and Clinical Characteristics of Campylobacteriosis Agents among Hospitalized Children with Acute Gastroenteritis in Lebanon" class="work-thumbnail" src="https://attachments.academia-assets.com/82008239/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73514886/Prevalence_Laboratory_Findings_and_Clinical_Characteristics_of_Campylobacteriosis_Agents_among_Hospitalized_Children_with_Acute_Gastroenteritis_in_Lebanon">Prevalence, Laboratory Findings and Clinical Characteristics of Campylobacteriosis Agents among Hospitalized Children with Acute Gastroenteritis in Lebanon</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Purpose Campylobacter species are currently the most common cause of bacterial gastroenteritis. I...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Purpose Campylobacter species are currently the most common cause of bacterial gastroenteritis. In Lebanon, Campylobacter infection occurrence is underdiagnosed owing to the lack of specific culture and rapid test kits, particularly among children. This study aimed to evaluate the prevalence, laboratory findings, and clinical characteristics of Campylobacter infection in hospitalized children with acute gastroenteritis in South Lebanon. Methods We conducted a 6-month retrospective cohort study between January and June 2018, including 291 children aged between 1 month and 12 years, who were admitted to a tertiary healthcare center in South Lebanon. The medical files of the patients were reviewed to retrieve the required clinical information, including clinical and laboratory data. Results The prevalence of campylobacteriosis agents in pediatric patients with acute gastroenteritis is 12.02%. Patients infected with Campylobacter had more severe acute gastroenteritis than Campylobacter-...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="73638473adb3ce70bc3769fd1cc8a96c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":82008239,"asset_id":73514886,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/82008239/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73514886"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73514886"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73514886; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "73638473adb3ce70bc3769fd1cc8a96c" } } $('.js-work-strip[data-work-id=73514886]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73514886,"title":"Prevalence, Laboratory Findings and Clinical Characteristics of Campylobacteriosis Agents among Hospitalized Children with Acute Gastroenteritis in Lebanon","internal_url":"https://www.academia.edu/73514886/Prevalence_Laboratory_Findings_and_Clinical_Characteristics_of_Campylobacteriosis_Agents_among_Hospitalized_Children_with_Acute_Gastroenteritis_in_Lebanon","owner_id":160895526,"coauthors_can_edit":true,"owner":{"id":160895526,"first_name":"Ali","middle_initials":null,"last_name":"El Roz","page_name":"AliElRoz","domain_name":"independent","created_at":"2020-06-11T23:06:32.079-07:00","display_name":"Ali El Roz","url":"https://independent.academia.edu/AliElRoz"},"attachments":[{"id":82008239,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/82008239/thumbnails/1.jpg","file_name":"JAKO202121061544454.pdf","download_url":"https://www.academia.edu/attachments/82008239/download_file","bulk_download_file_name":"Prevalence_Laboratory_Findings_and_Clini.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/82008239/JAKO202121061544454-libre.pdf?1646983272=\u0026response-content-disposition=attachment%3B+filename%3DPrevalence_Laboratory_Findings_and_Clini.pdf\u0026Expires=1740574124\u0026Signature=Jk6I5e0T323YxFK8vA9X2kf~VqLG~dc5JwQldpSg2RiItwkzJWxDVfl4cCSCN02uQN3TPTNtjIEQojBVLtwTM6227QvzVvFDLdDOX2TifnAJontVR1odXO2ikxumt1yZdYsFsedVfDk4hptC~oKqaN6naN66yRTwh0sKMFYAsN5DeDNMy47whWWidcVjVfGI~XPh-ptmK2nJOZoh6hMHzR6oIhs6UcLSVdcjK-141CqHwFP2qWV3nPr65dWmqIpfJNqZj8yzvnJoQXBG2gy3-pGirFq1dveWvEMpdQ08a3Lx7M6GUsGyt96X-zXegGOucZ0rfqoA-AoN4b~Y7sstNw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":82008238,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/82008238/thumbnails/1.jpg","file_name":"JAKO202121061544454.pdf","download_url":"https://www.academia.edu/attachments/82008238/download_file","bulk_download_file_name":"Prevalence_Laboratory_Findings_and_Clini.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/82008238/JAKO202121061544454-libre.pdf?1646983274=\u0026response-content-disposition=attachment%3B+filename%3DPrevalence_Laboratory_Findings_and_Clini.pdf\u0026Expires=1740574124\u0026Signature=OJj1g7xz~qjzHGH0yiF23hIx5~qXalxBxqBBXXVKsLoKs0uUdlFnFLeMLv9lLMg2JXaqRZPPKfYJ~4xskXcX~MeZIyYsKFgU0-c8xzIM4CZzENULyXzmojB66C~fHmt2B3mHtNA7M0MxiDieyNZKIqyoxDCEitS0xExOBlJfIMWCE2aogrgRHLhn~6cewoxBp-iz~UGylnUyS3J2RlvUzO3bIpImLVJEAoIr0eyBwChbv6qtMX7Vy3dkAmaW6s9Hq~cjGNGlUafAy-Ytj0se-G57GgXsf776JKrKB28yK--n5ixcqO9w3RBcfoAQEuEAsLBRQbUpdE7Hv2ragZW48A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73514885"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73514885/The_emergence_of_SARS_CoV_2_variant_s_and_its_impact_on_the_prevalence_of_COVID_19_cases_in_Nabatieh_region_Lebanon"><img alt="Research paper thumbnail of The emergence of SARS-CoV-2 variant(s) and its impact on the prevalence of COVID-19 cases in Nabatieh region, Lebanon" class="work-thumbnail" src="https://attachments.academia-assets.com/82008259/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73514885/The_emergence_of_SARS_CoV_2_variant_s_and_its_impact_on_the_prevalence_of_COVID_19_cases_in_Nabatieh_region_Lebanon">The emergence of SARS-CoV-2 variant(s) and its impact on the prevalence of COVID-19 cases in Nabatieh region, Lebanon</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: An outbreak of an unknown respiratory illness caused by a novel corona-virus, SARS-Co...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: An outbreak of an unknown respiratory illness caused by a novel corona-virus, SARS-CoV-2, emerged in the city of Wuhan in Hubei province, China, in December 2019 and was referred to as coronavirus disease-2019 (COVID-19). Soon after, it was declared as a global pandemic by the World Health Organization (WHO) in March 2020. SARS-CoV-2 mainly infects the respiratory tract with different outcomes ranging from asymptomatic infection to se-vere critical illness leading to death. Different SARS-CoV-2 variants are emerging of which three have raised concerns worldwide due to their high transmissibility among populations. Objec-tive: To study the prevalence of COVID-19 in the region of Nabatieh - South Lebanon during the past year and assess the presence of SARS-CoV-2 variants and their effect on the spread of infec-tion during times of lockdown. Methods: In our study, 37,474 nasopharyngeal swab samples were collected and analyzed for the detection of SARS-CoV-2 virus in suspect...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8259d42e7498811c8632b6f65c104640" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":82008259,"asset_id":73514885,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/82008259/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73514885"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73514885"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73514885; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73514885]").text(description); $(".js-view-count[data-work-id=73514885]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73514885; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73514885']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8259d42e7498811c8632b6f65c104640" } } $('.js-work-strip[data-work-id=73514885]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73514885,"title":"The emergence of SARS-CoV-2 variant(s) and its impact on the prevalence of COVID-19 cases in Nabatieh region, Lebanon","internal_url":"https://www.academia.edu/73514885/The_emergence_of_SARS_CoV_2_variant_s_and_its_impact_on_the_prevalence_of_COVID_19_cases_in_Nabatieh_region_Lebanon","owner_id":160895526,"coauthors_can_edit":true,"owner":{"id":160895526,"first_name":"Ali","middle_initials":null,"last_name":"El Roz","page_name":"AliElRoz","domain_name":"independent","created_at":"2020-06-11T23:06:32.079-07:00","display_name":"Ali El Roz","url":"https://independent.academia.edu/AliElRoz"},"attachments":[{"id":82008259,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/82008259/thumbnails/1.jpg","file_name":"2021.04.08.21255005.full.pdf","download_url":"https://www.academia.edu/attachments/82008259/download_file","bulk_download_file_name":"The_emergence_of_SARS_CoV_2_variant_s_an.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/82008259/2021.04.08.21255005.full-libre.pdf?1646983273=\u0026response-content-disposition=attachment%3B+filename%3DThe_emergence_of_SARS_CoV_2_variant_s_an.pdf\u0026Expires=1740574124\u0026Signature=g50QlvtjguNOB0GdAfQxh2eUXhJwc~rmLL1Y07WFTlnqSbnLi-QOaOPmU-grkruWz0TCr9tGeNFEb~HV4Qzf1t5e7uaYcqwEJGT6QOz5IxzVE8CpAvqixaC2EU0oYzChXFpq56IMkbtVafkwTDq-DBL~R~Kem5gqO-ovIGqNHbFvqFMfYCzIHPnL77c7FMgGPAnkDmtWY55XurkM1x5vggvZv9g4DEkv8MD7iV9pE0QwP8XgVYZdnqv57MS9yfEXEXlojfPuExIQooCTZjvXGIHLpL5ennSve6JVLyq1JYPw~iEW29pZ3hyrG00pcHxOC8O2yuKn-CIzmJNxXJY1TA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73514883"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73514883/LXR_agonists_and_ABCG1_dependent_cholesterol_efflux_in_MCF_7_breast_cancer_cells_relation_to_proliferation_and_apoptosis"><img alt="Research paper thumbnail of LXR agonists and ABCG1-dependent cholesterol efflux in MCF-7 breast cancer cells: relation to proliferation and apoptosis" class="work-thumbnail" src="https://attachments.academia-assets.com/82008236/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73514883/LXR_agonists_and_ABCG1_dependent_cholesterol_efflux_in_MCF_7_breast_cancer_cells_relation_to_proliferation_and_apoptosis">LXR agonists and ABCG1-dependent cholesterol efflux in MCF-7 breast cancer cells: relation to proliferation and apoptosis</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">BACKGROUND Liver X receptor (LXR) plays a key role in reverse cholesterol transport by inducing t...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">BACKGROUND Liver X receptor (LXR) plays a key role in reverse cholesterol transport by inducing the expression of the ATP-binding cassette (ABC) transporters, implicated in cholesterol efflux. Recent data showed that LXR agonists inhibit the proliferation of multiple types of human cancer cells. However, whether these effects are related to cholesterol efflux has not yet been elucidated. MATERIALS AND METHODS Effects of two LXR agonists (TO901317 and 22(R)-hydroxycholesterol [22(R)-HC]) on proliferation, apoptosis and cholesterol efflux were examined in MCF-7 breast cancer cells. RESULTS Treatment with LXR agonists (TO901317 at 20 渭M and 22(R)-HC at 2 渭g/ml) inhibited proliferation and induced apoptosis of MCF-7 cells. Furthermore, LXR activation resulted in an increase in gene and protein levels of ABCG1 transporters and in cholesterol efflux to isolated high-density lipoprotein (HDL), without affecting the ABCA1/APOA-I mediated efflux. Under these conditions, a remarkable reductio...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="78e063e8b60850c0068e3250ded200e8" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":82008236,"asset_id":73514883,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/82008236/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73514883"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73514883"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73514883; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73514883]").text(description); $(".js-view-count[data-work-id=73514883]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73514883; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73514883']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "78e063e8b60850c0068e3250ded200e8" } } $('.js-work-strip[data-work-id=73514883]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73514883,"title":"LXR agonists and ABCG1-dependent cholesterol efflux in MCF-7 breast cancer cells: relation to proliferation and apoptosis","internal_url":"https://www.academia.edu/73514883/LXR_agonists_and_ABCG1_dependent_cholesterol_efflux_in_MCF_7_breast_cancer_cells_relation_to_proliferation_and_apoptosis","owner_id":160895526,"coauthors_can_edit":true,"owner":{"id":160895526,"first_name":"Ali","middle_initials":null,"last_name":"El Roz","page_name":"AliElRoz","domain_name":"independent","created_at":"2020-06-11T23:06:32.079-07:00","display_name":"Ali El Roz","url":"https://independent.academia.edu/AliElRoz"},"attachments":[{"id":82008236,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/82008236/thumbnails/1.jpg","file_name":"3007.full.pdf","download_url":"https://www.academia.edu/attachments/82008236/download_file","bulk_download_file_name":"LXR_agonists_and_ABCG1_dependent_cholest.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/82008236/3007.full-libre.pdf?1646983271=\u0026response-content-disposition=attachment%3B+filename%3DLXR_agonists_and_ABCG1_dependent_cholest.pdf\u0026Expires=1740574124\u0026Signature=f9DkcfxlYSRbo7XNfbVHgKtRt76NW31Uz87e9NjhZAiMUI1q6hnjDFJVveDBVArLmufhl~nR6-0olmxm~kQv5Amt0LW7SGHCCK09Ka-pvrZxJjUll1Oy9UEiLIYAdB2Ux5FeDFpjeq0eMlUgXel~rD3mt-th9aMsHdxN0VXzU31hWWWoKU7sW31iBIXeICncCI0O13rwMoDKFcuFPkTqlsl-HV9VEjFD0v~ScBR16OP6Lf8Txc~dJ0c~2zQdTVD6wr8kpMdKQpnOLCTNhfSrm4Kw~IB3fYns7PwRG4mC9IwOIPPm9MYNn77TancWdEpq1rnQxkLx4NdWMJ7Itdt32g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":82008237,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/82008237/thumbnails/1.jpg","file_name":"3007.full.pdf","download_url":"https://www.academia.edu/attachments/82008237/download_file","bulk_download_file_name":"LXR_agonists_and_ABCG1_dependent_cholest.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/82008237/3007.full-libre.pdf?1646983271=\u0026response-content-disposition=attachment%3B+filename%3DLXR_agonists_and_ABCG1_dependent_cholest.pdf\u0026Expires=1740574124\u0026Signature=P3E2hDjTAgVDsSt4ebvSUzp2om4FMKfd0ZqsGDomXqboku5zv8DWfaOg9gVUBJjsOJoq9jKiN9k6A~KCNtMqX53Ppe0l-vpHPCag1T9lHjhb7EEzkaf8KqeH0SrW-RKJ30FJbEVFwKc00locngP8g8JM68S9PAoHpE8aPWLbfjLgz~SGCHi-KTShGoXacj9sz3YTEgoCobOMCD6AXSk2pF7Mjf3bp4S1nJusURnROSEYtPCBq5MfRu1l0g4zS-SwpUO299DbVwme9~Q7FPpr~Eryyuo4H8MhMwYgvrMuef-yHPO4sseKTzuV2we2l0QDqggGDDySTJP~ytOi0wVVfw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73514882"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73514882/Spectrum_of_MEFV_Variants_and_Genotypes_among_Clinically_Diagnosed_FMF_Patients_from_Southern_Lebanon"><img alt="Research paper thumbnail of Spectrum of MEFV Variants and Genotypes among Clinically Diagnosed FMF Patients from Southern Lebanon" class="work-thumbnail" src="https://attachments.academia-assets.com/82008235/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73514882/Spectrum_of_MEFV_Variants_and_Genotypes_among_Clinically_Diagnosed_FMF_Patients_from_Southern_Lebanon">Spectrum of MEFV Variants and Genotypes among Clinically Diagnosed FMF Patients from Southern Lebanon</a></div><div class="wp-workCard_item"><span>Medical Sciences</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Familial Mediterranean Fever (FMF) is an autosomal recessive auto-inflammatory diseas...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Familial Mediterranean Fever (FMF) is an autosomal recessive auto-inflammatory disease characterized by pathogenic variants in the MEFV gene, with allele frequencies greatly varying between countries, populations and ethnic groups. Materials and methods: In order to analyze the spectrum of MEFV variants and genotypes among clinically diagnosed FMF patients from South Lebanon, data were collected from 332 participants and 23 MEFV variants were screened using a Real-Time PCR Kit. Results: The mean age at symptom onset was 17.31 卤 13.82 years. The most prevalent symptoms were abdominal pain, fever and myalgia. MEFV molecular analysis showed that 111 patients (63.79%) were heterozygous, 16 (9.20%) were homozygous, and 47 (27.01%) carried two variants or more. E148Q was the most encountered variant among heterozygous subjects. E148Q/M694V was the most frequent in the compound heterozygous/complex genotype group, while M694I was the most common among homozygous patients. Regar...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2350394827cef4ee9873100da68e0b2d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":82008235,"asset_id":73514882,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/82008235/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73514882"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73514882"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73514882; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73514882]").text(description); $(".js-view-count[data-work-id=73514882]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73514882; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73514882']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2350394827cef4ee9873100da68e0b2d" } } $('.js-work-strip[data-work-id=73514882]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73514882,"title":"Spectrum of MEFV Variants and Genotypes among Clinically Diagnosed FMF Patients from Southern Lebanon","internal_url":"https://www.academia.edu/73514882/Spectrum_of_MEFV_Variants_and_Genotypes_among_Clinically_Diagnosed_FMF_Patients_from_Southern_Lebanon","owner_id":160895526,"coauthors_can_edit":true,"owner":{"id":160895526,"first_name":"Ali","middle_initials":null,"last_name":"El Roz","page_name":"AliElRoz","domain_name":"independent","created_at":"2020-06-11T23:06:32.079-07:00","display_name":"Ali El Roz","url":"https://independent.academia.edu/AliElRoz"},"attachments":[{"id":82008235,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/82008235/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/82008235/download_file","bulk_download_file_name":"Spectrum_of_MEFV_Variants_and_Genotypes.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/82008235/pdf-libre.pdf?1646983272=\u0026response-content-disposition=attachment%3B+filename%3DSpectrum_of_MEFV_Variants_and_Genotypes.pdf\u0026Expires=1740574124\u0026Signature=NvFpiaawFI7oQwvPqleUUJXPZwGlN9L8Xdt6Sk49TXTgOkvdcXdY2K8kDmalPc-1mBCE0hcqK3S~eTdJ0oXcsrOTLzRWJUJMI8dJ2gBqj3~43NOkhTNeAv681ttRqDB3Znj5EiUyhjdkq83XY-2fNnpmKqqC1v70BCLU2vbub4AUhrp2Rz~0bNQhPOmEq~Rl4qMNS0lEah4vw2aBNTO2Rnezu9p02vfIx~ukTZ0gBzuoxy~gCiapr2dRTDzgU2lJyRBVd3Ei~xujVvBMYunF~yJjH3OhEhggikM-X2Mt6aeFmSvRNIeLMKMbFTnMdoNG5IqaA2dZImImqbD3cT~8JA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":82008234,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/82008234/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/82008234/download_file","bulk_download_file_name":"Spectrum_of_MEFV_Variants_and_Genotypes.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/82008234/pdf-libre.pdf?1646983273=\u0026response-content-disposition=attachment%3B+filename%3DSpectrum_of_MEFV_Variants_and_Genotypes.pdf\u0026Expires=1740574124\u0026Signature=GAgPRTtIv3BhwtLZH80v4TnIjQer4pmz9j4W3YOmFk7C0kQZdDBuuvcxNY~J1WvgyiJHsF6Ym2MGoIPwCWNiumCOpdfBrRwGha9YSmvABbzX0tgstI5a6sVLlOg0bWDBY5BlrKe~l~Yqi6mbYrwQnxOYrUmxeQpATnUQX6f2kAkT0dHdHeY1UAc~FW499wXyKkX6Xi98yFtloDe-T8RCJ8x9N7eq3cvVMSbBlxXfwq8QelDsIO9jlMZPugP3hSPDzDKTuDdbJhHXqudr33kOx4d1Z7EfBUfnEmm~j4uoa6ycMdGcbpYX8gt468cqMfLxmiy0eMjX9AoLs6URyVplIQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73514881"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73514881/Prevalence_risk_factors_and_clinical_characteristics_of_rotavirus_and_adenovirus_among_Lebanese_hospitalized_children_with_acute_gastroenteritis"><img alt="Research paper thumbnail of Prevalence, risk factors, and clinical characteristics of rotavirus and adenovirus among Lebanese hospitalized children with acute gastroenteritis" class="work-thumbnail" src="https://attachments.academia-assets.com/82008262/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73514881/Prevalence_risk_factors_and_clinical_characteristics_of_rotavirus_and_adenovirus_among_Lebanese_hospitalized_children_with_acute_gastroenteritis">Prevalence, risk factors, and clinical characteristics of rotavirus and adenovirus among Lebanese hospitalized children with acute gastroenteritis</a></div><div class="wp-workCard_item"><span>Heliyon</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Acute gastroenteritis is a very common infectious disease facing all age groups world...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Acute gastroenteritis is a very common infectious disease facing all age groups worldwide, especially the pediatric population. Viruses, bacteria, and parasites are all possible causes of infectious gastroenteritis; however, viruses have become more frequently identified with the advances in the ability to diagnose viral infections, particularly rotavirus and adenovirus. We aimed in our study to compare between the prevalence, risk factors, and clinical characteristics of rotavirus and adenovirus among children with viral gastroenteritis in Lebanon. Materials and methods: A 12-months retrospective study was performed between January 1 st and December 31 st , 2018 including 308 children aged 1 month to 12 years, who were admitted to three tertiary healthcare centers in South Lebanon. Medical data were retrieved from patients' files, including clinical and laboratory information. Results: Rotavirus was found in stool of 204 patients (66.23 %), followed by adenovirus in 78 cases (25.32 %), and mixed group (rotavirus and adenovirus) in 26 cases (8.44%). The highest prevalence of rotavirus in our present study was seen among children between 12 and 23 months old, whereas patients infected with adenovirus were mainly aged between 24-35 months or 4-11 months. Majority of patients in the adenovirus and mixed groups had high-grade fever compared to the rotavirus group. Laboratory findings presented significantly higher average of white blood cells (WBCs), absolute neutrophil count (ANC), and C-reactive protein (CRP) in the mixed group compared to the two other groups. Monthly distribution of rotavirus and adenovirus infection revealed a biennial pattern of rotavirus incidence during January and July-August while frequency of adenovirus infection was highest during July-August. Conclusion: Due to the high prevalence of viral diarrhea among the pediatric age group in our region, particularly rotavirus and adenovirus, along with the associated non-specific signs and symptoms, we highly recommend that medical laboratories be equipped for virus detection. Also, vaccination against rotavirus should be considered as a prevention strategy.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7d429d42fc3d12f27ef403c001195f33" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":82008262,"asset_id":73514881,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/82008262/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73514881"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73514881"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73514881; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73514881]").text(description); $(".js-view-count[data-work-id=73514881]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73514881; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73514881']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7d429d42fc3d12f27ef403c001195f33" } } $('.js-work-strip[data-work-id=73514881]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73514881,"title":"Prevalence, risk factors, and clinical characteristics of rotavirus and adenovirus among Lebanese hospitalized children with acute gastroenteritis","internal_url":"https://www.academia.edu/73514881/Prevalence_risk_factors_and_clinical_characteristics_of_rotavirus_and_adenovirus_among_Lebanese_hospitalized_children_with_acute_gastroenteritis","owner_id":160895526,"coauthors_can_edit":true,"owner":{"id":160895526,"first_name":"Ali","middle_initials":null,"last_name":"El Roz","page_name":"AliElRoz","domain_name":"independent","created_at":"2020-06-11T23:06:32.079-07:00","display_name":"Ali El Roz","url":"https://independent.academia.edu/AliElRoz"},"attachments":[{"id":82008262,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/82008262/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/82008262/download_file","bulk_download_file_name":"Prevalence_risk_factors_and_clinical_cha.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/82008262/ptpmcrender-libre.pdf?1646983271=\u0026response-content-disposition=attachment%3B+filename%3DPrevalence_risk_factors_and_clinical_cha.pdf\u0026Expires=1740530416\u0026Signature=ekXd01kuCnshl-fb000Kd-2m~mFyWqjUBX-3TigZxKgLdZL9033E2va5SE9V5n68HRNh6kkUPD7EYTRXC4cbAi83eoFWQhHglZCoNVw0hmPkvkjcTLJPNGl9-SKA6NcYunK98vxWJC9fbEBEb8WS5X6wBsXwEhxXV35qmpAeda1vmWmWsFwcEaQ00eB9K7FDlUYhXfEZkq9Q~LGyFcYkkv-IynuSVxkyJ0fCH3xYz62znn4I3bwxByBqki~o0f3wmBmR8bpJevmAw~lNRdn45ATv5QkKrUcoNBqD90zQbUUWQ~ki8GGP5107UTbl5ayvliaQ5laYpOJXKBqrLHzGvA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73514880"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73514880/Emergence_of_Vulvovaginal_Candidiasis_among_Lebanese_Pregnant_Women_Prevalence_Risk_Factors_and_Species_Distribution"><img alt="Research paper thumbnail of Emergence of Vulvovaginal Candidiasis among Lebanese Pregnant Women: Prevalence, Risk Factors, and Species Distribution" class="work-thumbnail" src="https://attachments.academia-assets.com/82008233/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73514880/Emergence_of_Vulvovaginal_Candidiasis_among_Lebanese_Pregnant_Women_Prevalence_Risk_Factors_and_Species_Distribution">Emergence of Vulvovaginal Candidiasis among Lebanese Pregnant Women: Prevalence, Risk Factors, and Species Distribution</a></div><div class="wp-workCard_item"><span>Infectious Diseases in Obstetrics and Gynecology</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objective. Candida species colonize the vagina in at least 20% of women, with rates rising to 30%...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objective. Candida species colonize the vagina in at least 20% of women, with rates rising to 30% during pregnancy. This study aimed at determining the prevalence and risk factors of vulvovaginal candidiasis (VVC) in pregnant women at 35-37 weeks of gestation. It also aims at finding possible correlations between VVC and vaginal colonization by other agents, such as Group B Streptococcus (GBS) and bacterial vaginosis. Methodology. Over a one-year period, high vaginal swabs were collected from pregnant women during their regular antenatal checkup in different polyclinics in Beirut and South Lebanon. Swabs were examined microscopically, cultured on Sabouraud Dextrose Agar, and Candida isolates were identified using Chromatic Candida medium and Germ Tube Test. Results. VVC was detected in 44.8% of samples, with C. glabrata (44.4%) and C. albicans (43.4%) being the most isolated species. Approximately, half of pregnant women (57.7%) were coinfected with Candida and bacterial vaginosis, ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8c524524fb073adebc3da4f307f0eeff" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":82008233,"asset_id":73514880,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/82008233/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73514880"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73514880"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73514880; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73514879"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/73514879/Macrophage_apolipoprotein_E_and_proliferation_of_breast_cancer_cells_MCF_7_Role_of_LXR"><img alt="Research paper thumbnail of Macrophage apolipoprotein E and proliferation of breast cancer cells MCF-7: Role of LXR" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/73514879/Macrophage_apolipoprotein_E_and_proliferation_of_breast_cancer_cells_MCF_7_Role_of_LXR">Macrophage apolipoprotein E and proliferation of breast cancer cells MCF-7: Role of LXR</a></div><div class="wp-workCard_item"><span>The Faseb Journal</span><span>, Apr 1, 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Apolipoprotein E (APOE), a lipid transport protein that has a key role in the lipoprotein metabol...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Apolipoprotein E (APOE), a lipid transport protein that has a key role in the lipoprotein metabolism, is expressed by macrophages under the control of the transcription factor Liver X Receptor (LXR), an oxysterol-activated transcriptional factor involved in cholesterol metabolism. Recent work has shown that LXR agonists may inhibit breast cancer cell proliferation in vitro. We hypothesized that LXR-activated macrophages, and in particular secreted macrophagic APOE, may potentiate the effect of LXR agonists. Our goal was to evaluate the effect of APOE, secreted by THP-1 macrophages under the control of LXR, on MCF-7 cell proliferation, a model of breast cancer. MCF-7 cells were incubated with supernatants from THP-1 cells previously treated with LXR agonists [T0901317 or 22(R)-hydroxycholestrol], or supernatants from THP-1 cells transfected with siRNA against APOE mRNA. Viability assays and cell death quantification showed that media from LXR-activated macrophages reduced cell proliferation and increased apoptosis of MCF-7 cells. Interestingly, the opposite effects were observed when MCF-7 cells wre treated with media from the siRNA APOE-mediated knock-down model. This study highlights the protective role of LXR-activated macrophages against breast cancer growth, and the implication of APOE protein in the anti-proliferative and pro-apoptotic effects observed.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73514879"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73514879"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73514879; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73514879]").text(description); $(".js-view-count[data-work-id=73514879]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73514879; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73514879']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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Recent work has shown that LXR agonists may inhibit breast cancer cell proliferation in vitro. We hypothesized that LXR-activated macrophages, and in particular secreted macrophagic APOE, may potentiate the effect of LXR agonists. Our goal was to evaluate the effect of APOE, secreted by THP-1 macrophages under the control of LXR, on MCF-7 cell proliferation, a model of breast cancer. MCF-7 cells were incubated with supernatants from THP-1 cells previously treated with LXR agonists [T0901317 or 22(R)-hydroxycholestrol], or supernatants from THP-1 cells transfected with siRNA against APOE mRNA. Viability assays and cell death quantification showed that media from LXR-activated macrophages reduced cell prolif...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2141aaf1fb81c0f81a571fe8884e2720" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":82008263,"asset_id":73514878,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/82008263/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73514878"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73514878"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73514878; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73514878]").text(description); $(".js-view-count[data-work-id=73514878]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73514878; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73514878']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2141aaf1fb81c0f81a571fe8884e2720" } } $('.js-work-strip[data-work-id=73514878]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73514878,"title":"Macrophage apolipoprotein E and proliferation of MCF-7 breast cancer cells: role of LXR","internal_url":"https://www.academia.edu/73514878/Macrophage_apolipoprotein_E_and_proliferation_of_MCF_7_breast_cancer_cells_role_of_LXR","owner_id":160895526,"coauthors_can_edit":true,"owner":{"id":160895526,"first_name":"Ali","middle_initials":null,"last_name":"El Roz","page_name":"AliElRoz","domain_name":"independent","created_at":"2020-06-11T23:06:32.079-07:00","display_name":"Ali El Roz","url":"https://independent.academia.edu/AliElRoz"},"attachments":[{"id":82008263,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/82008263/thumbnails/1.jpg","file_name":"3783.full.pdf","download_url":"https://www.academia.edu/attachments/82008263/download_file","bulk_download_file_name":"Macrophage_apolipoprotein_E_and_prolifer.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/82008263/3783.full-libre.pdf?1646983269=\u0026response-content-disposition=attachment%3B+filename%3DMacrophage_apolipoprotein_E_and_prolifer.pdf\u0026Expires=1740574124\u0026Signature=H~1LQuQ8gXcRxu1G-ACPG4vZyiToxvP2agruWmHQ0DO~OE2civJ5jhwZXTioW2WBbT56CJKO557NJen03wT8ZL8VGa2lwdUmYG3jJQDkBPFljt3AMc3Huj~Kg2ALMJciMwvMBm1543NhU9NOmFM0Hy7c63S2PUIZGMFSxFNsB5AokV~wtN3WsL9cMYs8yO4MHMzdQjXhLLsKCTISOg4MRslBjGUS-4JVOk0B274HjwIJ91gZ5zkjdsP-dWfpFhshoZ4m6bqg0K~f1MWIrIsA8e9lADVqE2-0G57ucgSmsuqy6M93l-ZZg9E5-Y6Gb~158VhETApiUjDnIvIdeqwwmg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73514877"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73514877/LXR_agonists_and_ABCG1_dependent_cholesterol_efflux_in_MCF_7_breast_cancer_cells_relation_to_proliferation_and_apoptosis"><img alt="Research paper thumbnail of LXR agonists and ABCG1-dependent cholesterol efflux in MCF-7 breast cancer cells: relation to proliferation and apoptosis" class="work-thumbnail" src="https://attachments.academia-assets.com/82008261/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73514877/LXR_agonists_and_ABCG1_dependent_cholesterol_efflux_in_MCF_7_breast_cancer_cells_relation_to_proliferation_and_apoptosis">LXR agonists and ABCG1-dependent cholesterol efflux in MCF-7 breast cancer cells: relation to proliferation and apoptosis</a></div><div class="wp-workCard_item"><span>Anticancer research</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Liver X receptor (LXR) plays a key role in reverse cholesterol transport by inducing the expressi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Liver X receptor (LXR) plays a key role in reverse cholesterol transport by inducing the expression of the ATP-binding cassette (ABC) transporters, implicated in cholesterol efflux. Recent data showed that LXR agonists inhibit the proliferation of multiple types of human cancer cells. However, whether these effects are related to cholesterol efflux has not yet been elucidated. Effects of two LXR agonists (TO901317 and 22(R)-hydroxycholesterol [22(R)-HC]) on proliferation, apoptosis and cholesterol efflux were examined in MCF-7 breast cancer cells. Treatment with LXR agonists (TO901317 at 20 渭M and 22(R)-HC at 2 渭g/ml) inhibited proliferation and induced apoptosis of MCF-7 cells. Furthermore, LXR activation resulted in an increase in gene and protein levels of ABCG1 transporters and in cholesterol efflux to isolated high-density lipoprotein (HDL), without affecting the ABCA1/APOA-I mediated efflux. Under these conditions, a remarkable reduction of intracellular and membrane-associate...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="61e9a00ffa38241a7a26bfeef6885649" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":82008261,"asset_id":73514877,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/82008261/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73514877"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73514877"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73514877; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73514876"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/73514876/P150_L_effet_antiprolif%C3%A9ratif_de_l_isom%C3%A8re_trans9_trans11_de_l_acide_linol%C3%A9ique_conjugu%C3%A9_sur_les_cellules_du_cancer_du_sein_MCF_7_est_associ%C3%A9_%C3%A0_une_activation_du_facteur_nucl%C3%A9aire_LXR"><img alt="Research paper thumbnail of P150 L鈥檈ffet antiprolif茅ratif de l鈥檌som猫re trans9, trans11 de l鈥檃cide linol茅ique conjugu茅 sur les cellules du cancer du sein MCF-7 est associ茅脿 une activation du facteur nucl茅aire LXR" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/73514876/P150_L_effet_antiprolif%C3%A9ratif_de_l_isom%C3%A8re_trans9_trans11_de_l_acide_linol%C3%A9ique_conjugu%C3%A9_sur_les_cellules_du_cancer_du_sein_MCF_7_est_associ%C3%A9_%C3%A0_une_activation_du_facteur_nucl%C3%A9aire_LXR">P150 L鈥檈ffet antiprolif茅ratif de l鈥檌som猫re trans9, trans11 de l鈥檃cide linol茅ique conjugu茅 sur les cellules du cancer du sein MCF-7 est associ茅脿 une activation du facteur nucl茅aire LXR</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ABSTRACT Introduction et but de l&amp;#39;茅tude: Liver X Receptor (LXR) est un facteur nucl茅aire ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ABSTRACT Introduction et but de l&amp;#39;茅tude: Liver X Receptor (LXR) est un facteur nucl茅aire qui a un r么le dans le transport inverse du cholest茅rol, permettant le retour de ce lipide des tissus p茅riph茅riques vers le foie. Des travaux r茅cents sugg猫rent que LXR est impliqu茅 dans l&amp;#39;inhibition de la croissance des tumeurs. Les acides linol茅iques conjugu茅s (CLA), dont le pouvoir anti-tumoral est bien document茅, sont des acides gras pr茅sents dans les aliments d鈥檕rigine animale comme la viande de ruminants ou certains produits laitiers, et peuvent 茅galement 锚tre g茅n茅r茅s sous l鈥檃ction de la flore bact茅rienne intestinale. Certains isom猫res CLA, qui se distinguent par la g茅om茅trie cis (c) ou trans (t), et par le positionnement des doubles liaisons sur la cha卯ne carbon茅e, ont r茅cemment 茅t茅 pr茅sent茅s comme activateurs potentiels de LXR. L鈥檕bjectif de l鈥櫭﹖ude est d鈥櫭﹙aluer l鈥檈ffet de plusieurs isom猫res CLA sur la prolif茅ration et l鈥檃poptose d鈥檜ne lign茅e humaine de cancer du sein (MCF-7), et v茅rifier leur capacit茅脿 activer les g猫nes cibles de LXR. Mat茅riel et M茅thodes: Des tests MTT ont permis d鈥櫭﹙aluer le taux de prolif茅ration des cellules MCF-7 trait茅es pendant 24 heures avec 3 isom猫res CLA (c9,t11 ; t9,t11 et t10,c12). La mort cellulaire a 茅t茅 quantifi茅e par un marquage en cytom茅trie de flux par le fluorophore 7-AAD, qui se lie sur l鈥橝DN des cellules mortes. Enfin, le taux d鈥檈xpression des g猫nes et prot茅ines impliqu茅s dans l鈥檃poptose ainsi que des cibles de LXR, est analys茅 en qPCR et en Western Blot. R茅sultats: Les r茅sultats montrent que l鈥檌som猫re t9,t11-CLA a une efficacit茅 d鈥檌nhibition de la prolif茅ration et d鈥檌nduction d鈥檃poptose des cellules MCF-7 qui est bien sup茅rieure que celle des deux autres isom猫res test茅s. Ainsi, le t9,t11-CLA diminue la prolif茅ration des cellules MCF-7 de 50 % et induit une augmentation significative de l鈥檃poptose apr猫s 24h de traitement. En outre, les r茅sultats obtenus en qPCR montrent que cet isom猫re induit l鈥檈xpression du g猫ne proapoptotique BAX et inhibe celle du g猫ne anti-apoptotique Bcl-2. De plus, le traitement avec le t9,t11-CLA induit une alt茅ration de la morphologie cellulaire marqu茅e par l鈥檃pparition du ph茅nom猫ne de 芦 cell membrane blebbing 禄 qui caract茅rise les cellules apoptotiques. Nos r茅sultats en qPCR et en Western Blot montrent que l鈥檌som猫re t9,t11-CLA induit l鈥檈xpression de ABCA1, ABCG1 et ARL7, qui sont des cibles du facteur LXR et sont tous impliqu茅s dans l鈥檈fflux du cholest茅rol. Conclusion: Le pouvoir anti-tumoral des CLA est bien document茅. Cependant, le r么le individuel des isom猫res de CLA reste controvers茅 puisque la plupart des 茅tudes ont utilis茅 des m茅langes d鈥檌som猫res. Ici nous montrons que l鈥檌som猫re t9,t11-CLA a un effet anti-prolif茅ratif qui est sup茅rieur 脿 celui de deux autres isom猫res test茅s. Les r茅sultats obtenus montrent qu鈥檌l induit 茅galement l鈥檈xpression des g猫nes cibles de LXR, confirmant des r茅sultats r茅cents obtenus sur une lign茅e macrophagique. L鈥檃ctivation de LXR pourrait conduire 脿 priver les cellules canc茅reuses des lipides indispensables 脿 leur croissance en stimulant l鈥檈fflux du cholest茅rol. Il para卯t n茅cessaire de v茅rifier l鈥檌nt茅r锚t de la suppl茅mentation en CLA, agonistes de LXR, pour ralentir la progression de la maladie dans des mod猫les animaux de cancer du sein.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73514876"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73514876"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73514876; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73514875"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/73514875/The_anti_proliferative_and_pro_apoptotic_effects_of_the_trans9_trans11_conjugated_linoleic_acid_isomer_on_MCF_7_breast_cancer_cells_are_associated_with_LXR_activation"><img alt="Research paper thumbnail of The anti-proliferative and pro-apoptotic effects of the trans9,trans11 conjugated linoleic acid isomer on MCF-7 breast cancer cells are associated with LXR activation" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/73514875/The_anti_proliferative_and_pro_apoptotic_effects_of_the_trans9_trans11_conjugated_linoleic_acid_isomer_on_MCF_7_breast_cancer_cells_are_associated_with_LXR_activation">The anti-proliferative and pro-apoptotic effects of the trans9,trans11 conjugated linoleic acid isomer on MCF-7 breast cancer cells are associated with LXR activation</a></div><div class="wp-workCard_item"><span>Prostaglandins, Leukotrienes and Essential Fatty Acids</span><span>, 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Conjugated linoleic acids (CLA), naturally found in dairy products and ruminant meat, are positio...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Conjugated linoleic acids (CLA), naturally found in dairy products and ruminant meat, are positional and geometric isomers (trans: t or cis: c) of linoleic acid, and have been widely reported to possess anti-tumoral activity against breast cancer both in vitro and in vivo. CLA isomer t9,t11 was recently proposed as an agonist of the transcriptional factor LXR, which is known for inducing genes implicated in cholesterol efflux. In this study, the growth inhibitory effect of three CLA isomers (c9,t11-CLA, t9,t11-CLA and t10,c12-CLA) was investigated on MCF-7 breast cancer cells, as well as their effect on LXR target genes. Our results revealed that t9,t11-CLA was the most efficient isomer by decreasing MCF-7 proliferation, inhibiting migration, and inducing apoptosis after 24h of treatment. t9,t11-CLA treatment led to an increase in the mRNA levels of LXR target genes involved in cholesterol efflux (ABCG1 and ARL7), as well as an increase of HMG-CoA-reductase which is the rate-limiting step of cholesterol biosynthesis. Interestingly, confocal microscopy analysis showed that t9,t11-CLA treatment remarkably reduced the intracellular and membrane-associated cholesterol levels. LXR activation through t9,t11-CLA isomer could lead to cholesterol cell deprivation by stimulating its efflux, which results in the inhibition of cell proliferation and stimulation of apoptosis.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73514875"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73514875"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73514875; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=73514875]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73514875,"title":"The anti-proliferative and pro-apoptotic effects of the trans9,trans11 conjugated linoleic acid isomer on MCF-7 breast cancer cells are associated with LXR activation","internal_url":"https://www.academia.edu/73514875/The_anti_proliferative_and_pro_apoptotic_effects_of_the_trans9_trans11_conjugated_linoleic_acid_isomer_on_MCF_7_breast_cancer_cells_are_associated_with_LXR_activation","owner_id":160895526,"coauthors_can_edit":true,"owner":{"id":160895526,"first_name":"Ali","middle_initials":null,"last_name":"El Roz","page_name":"AliElRoz","domain_name":"independent","created_at":"2020-06-11T23:06:32.079-07:00","display_name":"Ali El Roz","url":"https://independent.academia.edu/AliElRoz"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="14270754" id="papers"><div class="js-work-strip profile--work_container" data-work-id="102985395"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/102985395/Risk_Markers_of_COVID_19_a_Study_from_South_Lebanon"><img alt="Research paper thumbnail of Risk Markers of COVID-19, a Study from South-Lebanon" class="work-thumbnail" src="https://attachments.academia-assets.com/103112281/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/102985395/Risk_Markers_of_COVID_19_a_Study_from_South_Lebanon">Risk Markers of COVID-19, a Study from South-Lebanon</a></div><div class="wp-workCard_item"><span>COVID</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: COVID-19, caused by the novel coronavirus SARS-CoV-2, was declared by WHO in early 20...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: COVID-19, caused by the novel coronavirus SARS-CoV-2, was declared by WHO in early 2020 as a worldwide pandemic. Several known risk markers are associated with COVID-19 morbidity and mortality, including age, gender, and diseases, such as hypertension, diabetes, and chronic cardiovascular diseases. Recent studies have shown an association between COVID-19 infection and the ABO blood groups. Objective: To assess the prevalence of SARS-CoV-2 among suspected COVID-19 patients as well as the risk markers for COVID-19 associated with ABO blood group, Rhesus factor, and patient鈥檚 address during the past year. Methods: 69,019 nasopharyngeal swab samples were collected and analyzed by reverse transcription polymerase chain reaction technique for the detection of SARS-CoV-2 in patients attending a tertiary health care center in South Lebanon during the period between August 2020 and July 2021. Results: Among all tested subjects, the prevalence of SARS-CoV-2 infection was 19.2% (9...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="283da7f83fb9364028d0cee6acfb9a13" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":103112281,"asset_id":102985395,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/103112281/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="102985395"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="102985395"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 102985395; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="102111742"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/102111742/Antiproliferative_and_proapoptotic_effects_of_histone_deacetylase_inhibitors_on_gastrointestinal_neuroendocrine_tumor_cells"><img alt="Research paper thumbnail of Antiproliferative and proapoptotic effects of histone deacetylase inhibitors on gastrointestinal neuroendocrine tumor cells" class="work-thumbnail" src="https://attachments.academia-assets.com/102462512/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/102111742/Antiproliferative_and_proapoptotic_effects_of_histone_deacetylase_inhibitors_on_gastrointestinal_neuroendocrine_tumor_cells">Antiproliferative and proapoptotic effects of histone deacetylase inhibitors on gastrointestinal neuroendocrine tumor cells</a></div><div class="wp-workCard_item"><span>Endocrine-Related Cancer</span><span>, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Treatment options of advanced neuroendocrine tumors (NETs) are unsatisfactory. Hence, innovative ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Treatment options of advanced neuroendocrine tumors (NETs) are unsatisfactory. Hence, innovative therapeutic approaches are urgently needed. Inhibition of histone deacetylases (HDACs) is a promising new approach in cancer therapy. While several HDAC inhibitors have already entered clinical trials, the effect of HDAC inhibition on NET has not been investigated. Therefore, we evaluated the antineoplastic effects of three different HDAC inhibitors, trichostatin A (TSA), sodium butyrate (NaB), and MS-275, on growth and apoptosis of the gastrointestinal NET cell lines CM and BON. We could demonstrate that HDAC inhibition dose-dependently inhibited proliferation of both cell lines with IC50 values varying from the millimolar (NaB) to the micromolar (MS-275) and the nanomolar range (TSA). Moreover, HDAC inhibition potently induced apoptosis, which was accompanied by DNA-fragmentation, an up to 12-fold caspase-3 activation and downregulated Bcl-2 expression. Furthermore, HDAC inhibition res...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5d066a6f71432324102244e6a957107b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":102462512,"asset_id":102111742,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/102462512/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="102111742"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="102111742"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 102111742; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5d066a6f71432324102244e6a957107b" } } $('.js-work-strip[data-work-id=102111742]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":102111742,"title":"Antiproliferative and proapoptotic effects of histone deacetylase inhibitors on gastrointestinal neuroendocrine tumor cells","internal_url":"https://www.academia.edu/102111742/Antiproliferative_and_proapoptotic_effects_of_histone_deacetylase_inhibitors_on_gastrointestinal_neuroendocrine_tumor_cells","owner_id":160895526,"coauthors_can_edit":true,"owner":{"id":160895526,"first_name":"Ali","middle_initials":null,"last_name":"El Roz","page_name":"AliElRoz","domain_name":"independent","created_at":"2020-06-11T23:06:32.079-07:00","display_name":"Ali El Roz","url":"https://independent.academia.edu/AliElRoz"},"attachments":[{"id":102462512,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/102462512/thumbnails/1.jpg","file_name":"0131237.pdf","download_url":"https://www.academia.edu/attachments/102462512/download_file","bulk_download_file_name":"Antiproliferative_and_proapoptotic_effec.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/102462512/0131237-libre.pdf?1684672039=\u0026response-content-disposition=attachment%3B+filename%3DAntiproliferative_and_proapoptotic_effec.pdf\u0026Expires=1740530416\u0026Signature=OWPB09yGtqhmLwpdJmpw0xl1yv5YroSrcmFhE3-4xLQEWuTYNvW6LaqbNcX~hsfNtoE58XeAei-fKr-tiNIL9fQCNTWyvwPMRYj3R5CrYV6HurEe4gYjLwjMJ6XjWX7qjo33ybShnDXEyKXLY89UV0vy5UPUE6WbWw11UtJG8oIrMfQajhVCCBxpZXmHtUWVBW4xum85P4uBFgPt4ml6B62g17g4q3QuZs41z3l-RVT4eiipGfKQg70mpXW3cJulfUhUO512B3DGRfBEDp05-rY1KjM81Yt~cPnjoLgtbu0V9l0Cpp8JzVqc~9r4CrPf~CUsKiHeHFTxw-lrgxVGNQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":102462513,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/102462513/thumbnails/1.jpg","file_name":"0131237.pdf","download_url":"https://www.academia.edu/attachments/102462513/download_file","bulk_download_file_name":"Antiproliferative_and_proapoptotic_effec.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/102462513/0131237-libre.pdf?1684672030=\u0026response-content-disposition=attachment%3B+filename%3DAntiproliferative_and_proapoptotic_effec.pdf\u0026Expires=1740530416\u0026Signature=VMXjprBkgcoE9VifsysBtp4vjcDvj9cLv3ox5AcXlYWg-aZQFA~Ir5A6eJ59iYPOs-QW629VEBQvalcLHFz21ZWskWJBeAfisE9aNSRlA9dp4z-A7ETGJs-P-pN0TmdX3z6ZByyNtG8hxKiuc9dV~95BWGvdLBN3jeS7dHsC0qdWH67iise8MSHcG85udHecw5H0EjFOJa0JLc609JMmBM~k25xEf8gayJViUf-8UpwXBBCx5Fq4MTgp1Bxfytz2z-9xWP4RhAqxT3l5oHB8F7YOwjHcgJDPGBFHrufy5bCL2RynQuQ7euMzrUO7fgq-hW0a9lQIF~KCNPcyGVWHXw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="102111740"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/102111740/The_emergence_of_SARS_CoV_2_variant_s_and_its_impact_on_the_prevalence_of_COVID_19_cases_in_Nabatieh_region_Lebanon"><img alt="Research paper thumbnail of The emergence of SARS-CoV-2 variant(s) and its impact on the prevalence of COVID-19 cases in Nabatieh region, Lebanon" class="work-thumbnail" src="https://attachments.academia-assets.com/102462535/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/102111740/The_emergence_of_SARS_CoV_2_variant_s_and_its_impact_on_the_prevalence_of_COVID_19_cases_in_Nabatieh_region_Lebanon">The emergence of SARS-CoV-2 variant(s) and its impact on the prevalence of COVID-19 cases in Nabatieh region, Lebanon</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">BackgroundAn outbreak of an unknown respiratory illness caused by a novel corona-virus, SARS-CoV-...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">BackgroundAn outbreak of an unknown respiratory illness caused by a novel corona-virus, SARS-CoV-2, emerged in the city of Wuhan in Hubei province, China, in December 2019 and was referred to as coronavirus disease-2019 (COVID-19). Soon after, it was declared as a global pandemic by the World Health Organization (WHO) in March 2020. SARS-CoV-2 mainly infects the respiratory tract with different outcomes ranging from asymptomatic infection to severe critical illness leading to death. Different SARS-CoV-2 variants are emerging of which three have raised concerns worldwide due to their high transmissibility among populations.ObjectiveTo study the prevalence of COVID-19 in the region of Nabatieh - South Lebanon during the past year and assess the presence of SARS-CoV-2 variants and their effect on the spread of infection during times of lock-down. Methods: In our study, 37,474 nasopharyngeal swab samples were collected and analyzed for the detection of SARS-CoV-2 virus in suspected pati...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ce6e8de13d154f398a9ad0a9ad2e0592" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":102462535,"asset_id":102111740,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/102462535/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="102111740"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="102111740"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 102111740; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ce6e8de13d154f398a9ad0a9ad2e0592" } } $('.js-work-strip[data-work-id=102111740]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":102111740,"title":"The emergence of SARS-CoV-2 variant(s) and its impact on the prevalence of COVID-19 cases in Nabatieh region, Lebanon","internal_url":"https://www.academia.edu/102111740/The_emergence_of_SARS_CoV_2_variant_s_and_its_impact_on_the_prevalence_of_COVID_19_cases_in_Nabatieh_region_Lebanon","owner_id":160895526,"coauthors_can_edit":true,"owner":{"id":160895526,"first_name":"Ali","middle_initials":null,"last_name":"El Roz","page_name":"AliElRoz","domain_name":"independent","created_at":"2020-06-11T23:06:32.079-07:00","display_name":"Ali El Roz","url":"https://independent.academia.edu/AliElRoz"},"attachments":[{"id":102462535,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/102462535/thumbnails/1.jpg","file_name":"2021.04.08.21255005.full.pdf","download_url":"https://www.academia.edu/attachments/102462535/download_file","bulk_download_file_name":"The_emergence_of_SARS_CoV_2_variant_s_an.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/102462535/2021.04.08.21255005.full-libre.pdf?1684672022=\u0026response-content-disposition=attachment%3B+filename%3DThe_emergence_of_SARS_CoV_2_variant_s_an.pdf\u0026Expires=1740574124\u0026Signature=Y8tahR1v0mTKzup-m3U0QT84ylHGaR0pqMlxsYhcqGXoJQKv18TcQjYGkiILk2dGHMKqtOY2pckG1JwJroYUVEb9Hq3RqaIA-h0jlukm0cMHRRcLfF~iCu0ncSIAjWJP5vH-xe8JPRsp8OHrAjMYM7qbmReVNpI-t-tEFKYfEc6JpZ4~xIYyqpLiwdlx5trT3emUa9oMLX14lDpwK~QBEf4egfXqSnjdUx9srKKcv9lFueE5oBk0ec-2s1z-wS1lMmzTdlRqgZ6jLqqc8r5XnF2-UVnwRVyGQIY-w2VDsmGq76M5rkgPRN9BQwO35566XYYl4025gPBAq1pVxzEslA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="99207961"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/99207961/Neuroblastoma_chemotherapy_can_be_augmented_by_immunotargeting_O_acetyl_GD2_tumor_associated_ganglioside"><img alt="Research paper thumbnail of Neuroblastoma chemotherapy can be augmented by immunotargeting O-acetyl-GD2 tumor-associated ganglioside" class="work-thumbnail" src="https://attachments.academia-assets.com/100357810/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/99207961/Neuroblastoma_chemotherapy_can_be_augmented_by_immunotargeting_O_acetyl_GD2_tumor_associated_ganglioside">Neuroblastoma chemotherapy can be augmented by immunotargeting O-acetyl-GD2 tumor-associated ganglioside</a></div><div class="wp-workCard_item"><span>OncoImmunology</span><span>, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Despite recent advances in high-risk neuroblastoma therapy, the prognosis for patients remains po...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Despite recent advances in high-risk neuroblastoma therapy, the prognosis for patients remains poor. In addition, many patients suffer from complications related to available therapies that are highly detrimental to their quality of life. New treatment modalities are, thus, urgently needed to further improve the efficacy and reduce the toxicity of existing therapies. Since antibodies specific for O-acetyl GD2 ganglioside display pro-apoptotic activity against neuroblastoma cells, we hypothesized that combination of immunotherapy could enhance tumor efficacy of neuroblastoma chemotherapy. We demonstrate here that combination of anti-O-acetyl GD2 monoclonal antibody 8B6 with topotecan synergistically inhibited neuroblastoma cell proliferation, as shown by the combination index values. Mechanistically, we evidence that mAb 8B6 induced plasma cell membrane lesions, consistent with oncosis. Neuroblastoma tumour cells treated with mAb 8B6 indeed showed an increased uptake of topotecan by the tumor cells and a more profound tumor cell death evidenced by increased caspase-3 activation. We also found that the combination with topotecan plus monoclonal antibody 8B6 showed a more potent anti-tumor efficacy in vivo than either agent alone. Importantly, we used low-doses of topotecan with no noticeable side effect. Our data suggest that chemo-immunotherapy combinations may improve the clinical efficacy and safety profile of current chemotherapeutic modalities of neuroblastoma.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8c4556c8a89505ccf4992c34b7994f67" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":100357810,"asset_id":99207961,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/100357810/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="99207961"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="99207961"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 99207961; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=99207961]").text(description); $(".js-view-count[data-work-id=99207961]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 99207961; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='99207961']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="99207957"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/99207957/Prevalence_of_Campylobacter_spp_in_broilers_in_North_Lebanon"><img alt="Research paper thumbnail of Prevalence of Campylobacter spp. in broilers in North Lebanon" class="work-thumbnail" src="https://attachments.academia-assets.com/100357765/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/99207957/Prevalence_of_Campylobacter_spp_in_broilers_in_North_Lebanon">Prevalence of Campylobacter spp. in broilers in North Lebanon</a></div><div class="wp-workCard_item"><span>Veterinary World</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background and Aim: Great attention has been given recently to the prevalence of different Campyl...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background and Aim: Great attention has been given recently to the prevalence of different Campylobacter spp. in poultry since the latter are considered the major contributing reservoir of human campylobacteriosis. In Lebanon, the occurrence of campylobacteriosis in humans is high. The aim of our first-of-its-kind study in the country was to estimate the prevalence of Campylobacter spp. in broilers from a convenient sample of farms in North Lebanon. Materials and Methods: One hundred twenty-five fecal samples were collected from 25 broiler farms, which were selected, examined, and classified according to their biosecurity level and rearing system. All samples were subjected to qualitative microbiological culture testing and polymerase chain reaction (PCR) assays to detect Campylobacter spp. Results: Despite the reported use of antibiotics, cell culture and PCR were positive for 44% and 88%, respectively. This implies that this bacterium is resistant to antibiotics used on the farms....</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="609d5626dadb110b9fce2b74b37e0dc7" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":100357765,"asset_id":99207957,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/100357765/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="99207957"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="99207957"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 99207957; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=99207957]").text(description); $(".js-view-count[data-work-id=99207957]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 99207957; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='99207957']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="86939947"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/86939947/Risk_Markers_of_COVID_19_a_Study_from_South_Lebanon"><img alt="Research paper thumbnail of Risk Markers of COVID-19, a Study from South-Lebanon" class="work-thumbnail" src="https://attachments.academia-assets.com/91284386/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/86939947/Risk_Markers_of_COVID_19_a_Study_from_South_Lebanon">Risk Markers of COVID-19, a Study from South-Lebanon</a></div><div class="wp-workCard_item"><span>COVID</span><span>, Jun 27, 2022</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This article is an open access article distributed under the terms and conditions of the Creative...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="452602b6c1f93793c79f18895f3f88ab" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91284386,"asset_id":86939947,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91284386/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="86939947"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="86939947"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 86939947; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73514889"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73514889/Antimicrobial_Susceptibilities_and_Laboratory_Profiles_of_Escherichia_coli_Klebsiella_pneumoniae_and_Proteus_mirabilis_Isolates_as_Agents_of_Urinary_Tract_Infection_in_Lebanon_Paving_the_Way_for_Better_Diagnostics"><img alt="Research paper thumbnail of Antimicrobial Susceptibilities and Laboratory Profiles of Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis Isolates as Agents of Urinary Tract Infection in Lebanon: Paving the Way for Better Diagnostics" class="work-thumbnail" src="https://attachments.academia-assets.com/82008260/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73514889/Antimicrobial_Susceptibilities_and_Laboratory_Profiles_of_Escherichia_coli_Klebsiella_pneumoniae_and_Proteus_mirabilis_Isolates_as_Agents_of_Urinary_Tract_Infection_in_Lebanon_Paving_the_Way_for_Better_Diagnostics">Antimicrobial Susceptibilities and Laboratory Profiles of Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis Isolates as Agents of Urinary Tract Infection in Lebanon: Paving the Way for Better Diagnostics</a></div><div class="wp-workCard_item"><span>Medical Sciences</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Urinary tract infections (UTIs) are major healthcare problems that are usually treate...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Urinary tract infections (UTIs) are major healthcare problems that are usually treated empirically. However, antimicrobial resistance has been increasing across many settings. This study aims to elucidate the antibiotic resistance profiles of three common uropathogens, Escherichia coli (E. coli), Klebsiella pneumoniae (K. pneumoniae), and Proteus mirabilis (P. mirabilis) and compare between extended spectrum beta-lactamase (ESBL) and non-ESBL strains among Lebanese patients. Methods: This retrospective study was conducted at multiple tertiary healthcare centers in South Lebanon, between January and September 2017, including 551 patients of all age groups. Demographic, clinical, and laboratory data of patients were collected and analyzed statistically. Results: The prevalence of UTI in Lebanon was highest in adults between 19 and 64 years (44%). E. coli was the predominant uropathogenic organism (67.1%) followed by K. pneumoniae (10%) and P. mirabilis (3.7%). ESBL represe...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="36c247a97e06766373bdf82719793176" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":82008260,"asset_id":73514889,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/82008260/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73514889"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73514889"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73514889; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73514888"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/73514888/R%C3%A9cepteur_nucl%C3%A9aire_LXR_et_cancer_du_sein_coop%C3%A9ration_avec_les_macrophages_%C3%A9tudes_in_vitro_sur_les_mod%C3%A8les_MCF_7_et_THP_1"><img alt="Research paper thumbnail of R茅cepteur nucl茅aire LXR et cancer du sein : coop茅ration avec les macrophages : 茅tudes in vitro sur les mod猫les MCF-7 et THP-1" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/73514888/R%C3%A9cepteur_nucl%C3%A9aire_LXR_et_cancer_du_sein_coop%C3%A9ration_avec_les_macrophages_%C3%A9tudes_in_vitro_sur_les_mod%C3%A8les_MCF_7_et_THP_1">R茅cepteur nucl茅aire LXR et cancer du sein : coop茅ration avec les macrophages : 茅tudes in vitro sur les mod猫les MCF-7 et THP-1</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Les nutriments lipidiques peuvent intervenir dans la modulation des cancers en interagissant avec...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Les nutriments lipidiques peuvent intervenir dans la modulation des cancers en interagissant avec leurs recepteurs nucleaires. Parmi ces recepteurs, nous avons etudie le role du facteur nucleaire Liver X Receptor (LXR) dans un modele cellulaire de cancer du sein (MCF-7). LXR joue un role essentiel dans l&#39;homeostasie lipidique et notamment dans le transport inverse du cholesterol, permettant le retour de ce lipide des tissus peripheriques vers le foie. D&#39;autre part, certains isomeres conjugues de l&#39;acide linoleique (CLA) presents dans les aliments comme les produits laitiers et la viande des ruminants, et dont le pouvoir anti-tumoral est bien documente, ont recemment ete presentes comme activateurs potentiels de LXR. Nos travaux ont permis de confirmer l&#39;importance de l&#39;activation de la voie LXR par un agoniste synthetique (T0901317) et sterolique [22(R)-HC] et par l&#39;isomere t9,t11-CLA pour inhiber la proliferation cellulaire et induire l&#39;apoptose dans les...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73514888"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73514888"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73514888; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); 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</script> <div class="js-work-strip profile--work_container" data-work-id="73514887"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73514887/The_Emergence_of_SARS_CoV_2_Variant_s_and_Its_Impact_on_the_Prevalence_of_COVID_19_Cases_in_the_Nabatieh_Region_Lebanon"><img alt="Research paper thumbnail of The Emergence of SARS-CoV-2 Variant(s) and Its Impact on the Prevalence of COVID-19 Cases in the Nabatieh Region, Lebanon" class="work-thumbnail" src="https://attachments.academia-assets.com/82008241/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73514887/The_Emergence_of_SARS_CoV_2_Variant_s_and_Its_Impact_on_the_Prevalence_of_COVID_19_Cases_in_the_Nabatieh_Region_Lebanon">The Emergence of SARS-CoV-2 Variant(s) and Its Impact on the Prevalence of COVID-19 Cases in the Nabatieh Region, Lebanon</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: An outbreak of an unknown respiratory illness caused by a novel coronavirus, SARS-CoV...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: An outbreak of an unknown respiratory illness caused by a novel coronavirus, SARS-CoV-2, emerged in the city of Wuhan in Hubei Province, China, in December 2019 and was referred to as coronavirus disease-2019 (COVID-19). Soon after, it was declared as a global pandemic by the World Health Organization (WHO) in March 2020. SARS-CoV-2 mainly infects the respiratory tract with different outcomes ranging from asymptomatic infection to severe critical illness leading to death. Different SARS-CoV-2 variants are emerging of which three have raised concerns worldwide due to their high transmissibility among populations. Objective: To study the prevalence of COVID-19 in the region of Nabatieh-South Lebanon during the past year and assess the presence of SARS-CoV-2 variants and their effect on the spread of infection during times of lockdown. Methods: In our study, 37,474 nasopharyngeal swab samples were collected and analyzed for the detection of SARS-CoV-2 virus in suspected pat...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a0adbac665c06e3ddb1b54592a789c40" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":82008241,"asset_id":73514887,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/82008241/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73514887"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73514887"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73514887; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73514887]").text(description); $(".js-view-count[data-work-id=73514887]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73514887; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73514887']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a0adbac665c06e3ddb1b54592a789c40" } } $('.js-work-strip[data-work-id=73514887]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73514887,"title":"The Emergence of SARS-CoV-2 Variant(s) and Its Impact on the Prevalence of COVID-19 Cases in the Nabatieh Region, Lebanon","internal_url":"https://www.academia.edu/73514887/The_Emergence_of_SARS_CoV_2_Variant_s_and_Its_Impact_on_the_Prevalence_of_COVID_19_Cases_in_the_Nabatieh_Region_Lebanon","owner_id":160895526,"coauthors_can_edit":true,"owner":{"id":160895526,"first_name":"Ali","middle_initials":null,"last_name":"El Roz","page_name":"AliElRoz","domain_name":"independent","created_at":"2020-06-11T23:06:32.079-07:00","display_name":"Ali El Roz","url":"https://independent.academia.edu/AliElRoz"},"attachments":[{"id":82008241,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/82008241/thumbnails/1.jpg","file_name":"medsci-09-00040.pdf","download_url":"https://www.academia.edu/attachments/82008241/download_file","bulk_download_file_name":"The_Emergence_of_SARS_CoV_2_Variant_s_an.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/82008241/medsci-09-00040-libre.pdf?1646983275=\u0026response-content-disposition=attachment%3B+filename%3DThe_Emergence_of_SARS_CoV_2_Variant_s_an.pdf\u0026Expires=1740530416\u0026Signature=LM-v9OnNvSMIQruIt9gt9ipKFUcTL5WPeyh2-yx9ZseHRUpBcIWCpO1WUyI8M5u3U87c4MyzeF5qIh7j199m7r2Db0z80DDjnlixPCI7kLlNlh7NAH6fKni6X88kczOWhru9B1uvScxhkFKDWRNSDcabKie3IWMsYiWU9CqdN8JEgRCrAVreOqavKfb7KzntrZYYDRtPbx2mr0GktsuuNYH6c9xeXfrprOU0DB~if6wwinBxl57P1d2C5tWU6tVMjfNBnEYz6hOpwJrMuU7Z5mt9DBgGOnYG8EZ3OKS-jMdAtWumNuV0Bgso52x9WQFXzeu-9Ew7N1KROc~bozdB9g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":82008240,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/82008240/thumbnails/1.jpg","file_name":"medsci-09-00040.pdf","download_url":"https://www.academia.edu/attachments/82008240/download_file","bulk_download_file_name":"The_Emergence_of_SARS_CoV_2_Variant_s_an.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/82008240/medsci-09-00040-libre.pdf?1646983275=\u0026response-content-disposition=attachment%3B+filename%3DThe_Emergence_of_SARS_CoV_2_Variant_s_an.pdf\u0026Expires=1740530416\u0026Signature=SrUozSD5wjnFB8rYhFoBjuLIcyUN03k3vUTyQt79o9kIbEOWciJAX-5gAgbIoucv7pKSYrmXACMeqVzWha5coarOnGlrARuj0KKg55konOHxdp27yje1wVWPJ8VP~GaCmjnq9cD5Lx71w54qpRXmYRxe1RiKiEIhuilVuiO2oGIqqstyUxCPn6f-aCwAr3pWRpIJErmi0otoikP8ic9pA8TH2Q4z~Mr5p~qVqNngUHEOAIo4jve~glLA3yYMc57VegrXtKhQljMpAMJawjqVSb2GyT3vkwSiAXoXERIR0UdKcHNZlXvIjSS1eymet6Ob8bHwhbwDmtmh2-dPLhS6zA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73514886"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73514886/Prevalence_Laboratory_Findings_and_Clinical_Characteristics_of_Campylobacteriosis_Agents_among_Hospitalized_Children_with_Acute_Gastroenteritis_in_Lebanon"><img alt="Research paper thumbnail of Prevalence, Laboratory Findings and Clinical Characteristics of Campylobacteriosis Agents among Hospitalized Children with Acute Gastroenteritis in Lebanon" class="work-thumbnail" src="https://attachments.academia-assets.com/82008239/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73514886/Prevalence_Laboratory_Findings_and_Clinical_Characteristics_of_Campylobacteriosis_Agents_among_Hospitalized_Children_with_Acute_Gastroenteritis_in_Lebanon">Prevalence, Laboratory Findings and Clinical Characteristics of Campylobacteriosis Agents among Hospitalized Children with Acute Gastroenteritis in Lebanon</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Purpose Campylobacter species are currently the most common cause of bacterial gastroenteritis. I...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Purpose Campylobacter species are currently the most common cause of bacterial gastroenteritis. In Lebanon, Campylobacter infection occurrence is underdiagnosed owing to the lack of specific culture and rapid test kits, particularly among children. This study aimed to evaluate the prevalence, laboratory findings, and clinical characteristics of Campylobacter infection in hospitalized children with acute gastroenteritis in South Lebanon. Methods We conducted a 6-month retrospective cohort study between January and June 2018, including 291 children aged between 1 month and 12 years, who were admitted to a tertiary healthcare center in South Lebanon. The medical files of the patients were reviewed to retrieve the required clinical information, including clinical and laboratory data. Results The prevalence of campylobacteriosis agents in pediatric patients with acute gastroenteritis is 12.02%. Patients infected with Campylobacter had more severe acute gastroenteritis than Campylobacter-...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="73638473adb3ce70bc3769fd1cc8a96c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":82008239,"asset_id":73514886,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/82008239/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73514886"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73514886"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73514886; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73514886]").text(description); $(".js-view-count[data-work-id=73514886]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73514886; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73514886']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "73638473adb3ce70bc3769fd1cc8a96c" } } $('.js-work-strip[data-work-id=73514886]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73514886,"title":"Prevalence, Laboratory Findings and Clinical Characteristics of Campylobacteriosis Agents among Hospitalized Children with Acute Gastroenteritis in Lebanon","internal_url":"https://www.academia.edu/73514886/Prevalence_Laboratory_Findings_and_Clinical_Characteristics_of_Campylobacteriosis_Agents_among_Hospitalized_Children_with_Acute_Gastroenteritis_in_Lebanon","owner_id":160895526,"coauthors_can_edit":true,"owner":{"id":160895526,"first_name":"Ali","middle_initials":null,"last_name":"El Roz","page_name":"AliElRoz","domain_name":"independent","created_at":"2020-06-11T23:06:32.079-07:00","display_name":"Ali El Roz","url":"https://independent.academia.edu/AliElRoz"},"attachments":[{"id":82008239,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/82008239/thumbnails/1.jpg","file_name":"JAKO202121061544454.pdf","download_url":"https://www.academia.edu/attachments/82008239/download_file","bulk_download_file_name":"Prevalence_Laboratory_Findings_and_Clini.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/82008239/JAKO202121061544454-libre.pdf?1646983272=\u0026response-content-disposition=attachment%3B+filename%3DPrevalence_Laboratory_Findings_and_Clini.pdf\u0026Expires=1740574124\u0026Signature=Jk6I5e0T323YxFK8vA9X2kf~VqLG~dc5JwQldpSg2RiItwkzJWxDVfl4cCSCN02uQN3TPTNtjIEQojBVLtwTM6227QvzVvFDLdDOX2TifnAJontVR1odXO2ikxumt1yZdYsFsedVfDk4hptC~oKqaN6naN66yRTwh0sKMFYAsN5DeDNMy47whWWidcVjVfGI~XPh-ptmK2nJOZoh6hMHzR6oIhs6UcLSVdcjK-141CqHwFP2qWV3nPr65dWmqIpfJNqZj8yzvnJoQXBG2gy3-pGirFq1dveWvEMpdQ08a3Lx7M6GUsGyt96X-zXegGOucZ0rfqoA-AoN4b~Y7sstNw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":82008238,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/82008238/thumbnails/1.jpg","file_name":"JAKO202121061544454.pdf","download_url":"https://www.academia.edu/attachments/82008238/download_file","bulk_download_file_name":"Prevalence_Laboratory_Findings_and_Clini.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/82008238/JAKO202121061544454-libre.pdf?1646983274=\u0026response-content-disposition=attachment%3B+filename%3DPrevalence_Laboratory_Findings_and_Clini.pdf\u0026Expires=1740574124\u0026Signature=OJj1g7xz~qjzHGH0yiF23hIx5~qXalxBxqBBXXVKsLoKs0uUdlFnFLeMLv9lLMg2JXaqRZPPKfYJ~4xskXcX~MeZIyYsKFgU0-c8xzIM4CZzENULyXzmojB66C~fHmt2B3mHtNA7M0MxiDieyNZKIqyoxDCEitS0xExOBlJfIMWCE2aogrgRHLhn~6cewoxBp-iz~UGylnUyS3J2RlvUzO3bIpImLVJEAoIr0eyBwChbv6qtMX7Vy3dkAmaW6s9Hq~cjGNGlUafAy-Ytj0se-G57GgXsf776JKrKB28yK--n5ixcqO9w3RBcfoAQEuEAsLBRQbUpdE7Hv2ragZW48A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73514885"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73514885/The_emergence_of_SARS_CoV_2_variant_s_and_its_impact_on_the_prevalence_of_COVID_19_cases_in_Nabatieh_region_Lebanon"><img alt="Research paper thumbnail of The emergence of SARS-CoV-2 variant(s) and its impact on the prevalence of COVID-19 cases in Nabatieh region, Lebanon" class="work-thumbnail" src="https://attachments.academia-assets.com/82008259/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73514885/The_emergence_of_SARS_CoV_2_variant_s_and_its_impact_on_the_prevalence_of_COVID_19_cases_in_Nabatieh_region_Lebanon">The emergence of SARS-CoV-2 variant(s) and its impact on the prevalence of COVID-19 cases in Nabatieh region, Lebanon</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: An outbreak of an unknown respiratory illness caused by a novel corona-virus, SARS-Co...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: An outbreak of an unknown respiratory illness caused by a novel corona-virus, SARS-CoV-2, emerged in the city of Wuhan in Hubei province, China, in December 2019 and was referred to as coronavirus disease-2019 (COVID-19). Soon after, it was declared as a global pandemic by the World Health Organization (WHO) in March 2020. SARS-CoV-2 mainly infects the respiratory tract with different outcomes ranging from asymptomatic infection to se-vere critical illness leading to death. Different SARS-CoV-2 variants are emerging of which three have raised concerns worldwide due to their high transmissibility among populations. Objec-tive: To study the prevalence of COVID-19 in the region of Nabatieh - South Lebanon during the past year and assess the presence of SARS-CoV-2 variants and their effect on the spread of infec-tion during times of lockdown. Methods: In our study, 37,474 nasopharyngeal swab samples were collected and analyzed for the detection of SARS-CoV-2 virus in suspect...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8259d42e7498811c8632b6f65c104640" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":82008259,"asset_id":73514885,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/82008259/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73514885"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73514885"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73514885; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73514885]").text(description); $(".js-view-count[data-work-id=73514885]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73514885; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73514885']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8259d42e7498811c8632b6f65c104640" } } $('.js-work-strip[data-work-id=73514885]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73514885,"title":"The emergence of SARS-CoV-2 variant(s) and its impact on the prevalence of COVID-19 cases in Nabatieh region, Lebanon","internal_url":"https://www.academia.edu/73514885/The_emergence_of_SARS_CoV_2_variant_s_and_its_impact_on_the_prevalence_of_COVID_19_cases_in_Nabatieh_region_Lebanon","owner_id":160895526,"coauthors_can_edit":true,"owner":{"id":160895526,"first_name":"Ali","middle_initials":null,"last_name":"El Roz","page_name":"AliElRoz","domain_name":"independent","created_at":"2020-06-11T23:06:32.079-07:00","display_name":"Ali El Roz","url":"https://independent.academia.edu/AliElRoz"},"attachments":[{"id":82008259,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/82008259/thumbnails/1.jpg","file_name":"2021.04.08.21255005.full.pdf","download_url":"https://www.academia.edu/attachments/82008259/download_file","bulk_download_file_name":"The_emergence_of_SARS_CoV_2_variant_s_an.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/82008259/2021.04.08.21255005.full-libre.pdf?1646983273=\u0026response-content-disposition=attachment%3B+filename%3DThe_emergence_of_SARS_CoV_2_variant_s_an.pdf\u0026Expires=1740574124\u0026Signature=g50QlvtjguNOB0GdAfQxh2eUXhJwc~rmLL1Y07WFTlnqSbnLi-QOaOPmU-grkruWz0TCr9tGeNFEb~HV4Qzf1t5e7uaYcqwEJGT6QOz5IxzVE8CpAvqixaC2EU0oYzChXFpq56IMkbtVafkwTDq-DBL~R~Kem5gqO-ovIGqNHbFvqFMfYCzIHPnL77c7FMgGPAnkDmtWY55XurkM1x5vggvZv9g4DEkv8MD7iV9pE0QwP8XgVYZdnqv57MS9yfEXEXlojfPuExIQooCTZjvXGIHLpL5ennSve6JVLyq1JYPw~iEW29pZ3hyrG00pcHxOC8O2yuKn-CIzmJNxXJY1TA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73514883"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73514883/LXR_agonists_and_ABCG1_dependent_cholesterol_efflux_in_MCF_7_breast_cancer_cells_relation_to_proliferation_and_apoptosis"><img alt="Research paper thumbnail of LXR agonists and ABCG1-dependent cholesterol efflux in MCF-7 breast cancer cells: relation to proliferation and apoptosis" class="work-thumbnail" src="https://attachments.academia-assets.com/82008236/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73514883/LXR_agonists_and_ABCG1_dependent_cholesterol_efflux_in_MCF_7_breast_cancer_cells_relation_to_proliferation_and_apoptosis">LXR agonists and ABCG1-dependent cholesterol efflux in MCF-7 breast cancer cells: relation to proliferation and apoptosis</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">BACKGROUND Liver X receptor (LXR) plays a key role in reverse cholesterol transport by inducing t...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">BACKGROUND Liver X receptor (LXR) plays a key role in reverse cholesterol transport by inducing the expression of the ATP-binding cassette (ABC) transporters, implicated in cholesterol efflux. Recent data showed that LXR agonists inhibit the proliferation of multiple types of human cancer cells. However, whether these effects are related to cholesterol efflux has not yet been elucidated. MATERIALS AND METHODS Effects of two LXR agonists (TO901317 and 22(R)-hydroxycholesterol [22(R)-HC]) on proliferation, apoptosis and cholesterol efflux were examined in MCF-7 breast cancer cells. RESULTS Treatment with LXR agonists (TO901317 at 20 渭M and 22(R)-HC at 2 渭g/ml) inhibited proliferation and induced apoptosis of MCF-7 cells. Furthermore, LXR activation resulted in an increase in gene and protein levels of ABCG1 transporters and in cholesterol efflux to isolated high-density lipoprotein (HDL), without affecting the ABCA1/APOA-I mediated efflux. Under these conditions, a remarkable reductio...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="78e063e8b60850c0068e3250ded200e8" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":82008236,"asset_id":73514883,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/82008236/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73514883"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73514883"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73514883; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73514883]").text(description); $(".js-view-count[data-work-id=73514883]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73514883; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73514883']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "78e063e8b60850c0068e3250ded200e8" } } $('.js-work-strip[data-work-id=73514883]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73514883,"title":"LXR agonists and ABCG1-dependent cholesterol efflux in MCF-7 breast cancer cells: relation to proliferation and apoptosis","internal_url":"https://www.academia.edu/73514883/LXR_agonists_and_ABCG1_dependent_cholesterol_efflux_in_MCF_7_breast_cancer_cells_relation_to_proliferation_and_apoptosis","owner_id":160895526,"coauthors_can_edit":true,"owner":{"id":160895526,"first_name":"Ali","middle_initials":null,"last_name":"El Roz","page_name":"AliElRoz","domain_name":"independent","created_at":"2020-06-11T23:06:32.079-07:00","display_name":"Ali El Roz","url":"https://independent.academia.edu/AliElRoz"},"attachments":[{"id":82008236,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/82008236/thumbnails/1.jpg","file_name":"3007.full.pdf","download_url":"https://www.academia.edu/attachments/82008236/download_file","bulk_download_file_name":"LXR_agonists_and_ABCG1_dependent_cholest.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/82008236/3007.full-libre.pdf?1646983271=\u0026response-content-disposition=attachment%3B+filename%3DLXR_agonists_and_ABCG1_dependent_cholest.pdf\u0026Expires=1740574124\u0026Signature=f9DkcfxlYSRbo7XNfbVHgKtRt76NW31Uz87e9NjhZAiMUI1q6hnjDFJVveDBVArLmufhl~nR6-0olmxm~kQv5Amt0LW7SGHCCK09Ka-pvrZxJjUll1Oy9UEiLIYAdB2Ux5FeDFpjeq0eMlUgXel~rD3mt-th9aMsHdxN0VXzU31hWWWoKU7sW31iBIXeICncCI0O13rwMoDKFcuFPkTqlsl-HV9VEjFD0v~ScBR16OP6Lf8Txc~dJ0c~2zQdTVD6wr8kpMdKQpnOLCTNhfSrm4Kw~IB3fYns7PwRG4mC9IwOIPPm9MYNn77TancWdEpq1rnQxkLx4NdWMJ7Itdt32g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":82008237,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/82008237/thumbnails/1.jpg","file_name":"3007.full.pdf","download_url":"https://www.academia.edu/attachments/82008237/download_file","bulk_download_file_name":"LXR_agonists_and_ABCG1_dependent_cholest.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/82008237/3007.full-libre.pdf?1646983271=\u0026response-content-disposition=attachment%3B+filename%3DLXR_agonists_and_ABCG1_dependent_cholest.pdf\u0026Expires=1740574124\u0026Signature=P3E2hDjTAgVDsSt4ebvSUzp2om4FMKfd0ZqsGDomXqboku5zv8DWfaOg9gVUBJjsOJoq9jKiN9k6A~KCNtMqX53Ppe0l-vpHPCag1T9lHjhb7EEzkaf8KqeH0SrW-RKJ30FJbEVFwKc00locngP8g8JM68S9PAoHpE8aPWLbfjLgz~SGCHi-KTShGoXacj9sz3YTEgoCobOMCD6AXSk2pF7Mjf3bp4S1nJusURnROSEYtPCBq5MfRu1l0g4zS-SwpUO299DbVwme9~Q7FPpr~Eryyuo4H8MhMwYgvrMuef-yHPO4sseKTzuV2we2l0QDqggGDDySTJP~ytOi0wVVfw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73514882"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73514882/Spectrum_of_MEFV_Variants_and_Genotypes_among_Clinically_Diagnosed_FMF_Patients_from_Southern_Lebanon"><img alt="Research paper thumbnail of Spectrum of MEFV Variants and Genotypes among Clinically Diagnosed FMF Patients from Southern Lebanon" class="work-thumbnail" src="https://attachments.academia-assets.com/82008235/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73514882/Spectrum_of_MEFV_Variants_and_Genotypes_among_Clinically_Diagnosed_FMF_Patients_from_Southern_Lebanon">Spectrum of MEFV Variants and Genotypes among Clinically Diagnosed FMF Patients from Southern Lebanon</a></div><div class="wp-workCard_item"><span>Medical Sciences</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Familial Mediterranean Fever (FMF) is an autosomal recessive auto-inflammatory diseas...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Familial Mediterranean Fever (FMF) is an autosomal recessive auto-inflammatory disease characterized by pathogenic variants in the MEFV gene, with allele frequencies greatly varying between countries, populations and ethnic groups. Materials and methods: In order to analyze the spectrum of MEFV variants and genotypes among clinically diagnosed FMF patients from South Lebanon, data were collected from 332 participants and 23 MEFV variants were screened using a Real-Time PCR Kit. Results: The mean age at symptom onset was 17.31 卤 13.82 years. The most prevalent symptoms were abdominal pain, fever and myalgia. MEFV molecular analysis showed that 111 patients (63.79%) were heterozygous, 16 (9.20%) were homozygous, and 47 (27.01%) carried two variants or more. E148Q was the most encountered variant among heterozygous subjects. E148Q/M694V was the most frequent in the compound heterozygous/complex genotype group, while M694I was the most common among homozygous patients. Regar...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2350394827cef4ee9873100da68e0b2d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":82008235,"asset_id":73514882,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/82008235/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73514882"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73514882"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73514882; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73514882]").text(description); $(".js-view-count[data-work-id=73514882]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73514882; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73514882']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2350394827cef4ee9873100da68e0b2d" } } $('.js-work-strip[data-work-id=73514882]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73514882,"title":"Spectrum of MEFV Variants and Genotypes among Clinically Diagnosed FMF Patients from Southern Lebanon","internal_url":"https://www.academia.edu/73514882/Spectrum_of_MEFV_Variants_and_Genotypes_among_Clinically_Diagnosed_FMF_Patients_from_Southern_Lebanon","owner_id":160895526,"coauthors_can_edit":true,"owner":{"id":160895526,"first_name":"Ali","middle_initials":null,"last_name":"El Roz","page_name":"AliElRoz","domain_name":"independent","created_at":"2020-06-11T23:06:32.079-07:00","display_name":"Ali El Roz","url":"https://independent.academia.edu/AliElRoz"},"attachments":[{"id":82008235,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/82008235/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/82008235/download_file","bulk_download_file_name":"Spectrum_of_MEFV_Variants_and_Genotypes.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/82008235/pdf-libre.pdf?1646983272=\u0026response-content-disposition=attachment%3B+filename%3DSpectrum_of_MEFV_Variants_and_Genotypes.pdf\u0026Expires=1740574124\u0026Signature=NvFpiaawFI7oQwvPqleUUJXPZwGlN9L8Xdt6Sk49TXTgOkvdcXdY2K8kDmalPc-1mBCE0hcqK3S~eTdJ0oXcsrOTLzRWJUJMI8dJ2gBqj3~43NOkhTNeAv681ttRqDB3Znj5EiUyhjdkq83XY-2fNnpmKqqC1v70BCLU2vbub4AUhrp2Rz~0bNQhPOmEq~Rl4qMNS0lEah4vw2aBNTO2Rnezu9p02vfIx~ukTZ0gBzuoxy~gCiapr2dRTDzgU2lJyRBVd3Ei~xujVvBMYunF~yJjH3OhEhggikM-X2Mt6aeFmSvRNIeLMKMbFTnMdoNG5IqaA2dZImImqbD3cT~8JA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":82008234,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/82008234/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/82008234/download_file","bulk_download_file_name":"Spectrum_of_MEFV_Variants_and_Genotypes.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/82008234/pdf-libre.pdf?1646983273=\u0026response-content-disposition=attachment%3B+filename%3DSpectrum_of_MEFV_Variants_and_Genotypes.pdf\u0026Expires=1740574124\u0026Signature=GAgPRTtIv3BhwtLZH80v4TnIjQer4pmz9j4W3YOmFk7C0kQZdDBuuvcxNY~J1WvgyiJHsF6Ym2MGoIPwCWNiumCOpdfBrRwGha9YSmvABbzX0tgstI5a6sVLlOg0bWDBY5BlrKe~l~Yqi6mbYrwQnxOYrUmxeQpATnUQX6f2kAkT0dHdHeY1UAc~FW499wXyKkX6Xi98yFtloDe-T8RCJ8x9N7eq3cvVMSbBlxXfwq8QelDsIO9jlMZPugP3hSPDzDKTuDdbJhHXqudr33kOx4d1Z7EfBUfnEmm~j4uoa6ycMdGcbpYX8gt468cqMfLxmiy0eMjX9AoLs6URyVplIQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73514881"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73514881/Prevalence_risk_factors_and_clinical_characteristics_of_rotavirus_and_adenovirus_among_Lebanese_hospitalized_children_with_acute_gastroenteritis"><img alt="Research paper thumbnail of Prevalence, risk factors, and clinical characteristics of rotavirus and adenovirus among Lebanese hospitalized children with acute gastroenteritis" class="work-thumbnail" src="https://attachments.academia-assets.com/82008262/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73514881/Prevalence_risk_factors_and_clinical_characteristics_of_rotavirus_and_adenovirus_among_Lebanese_hospitalized_children_with_acute_gastroenteritis">Prevalence, risk factors, and clinical characteristics of rotavirus and adenovirus among Lebanese hospitalized children with acute gastroenteritis</a></div><div class="wp-workCard_item"><span>Heliyon</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Acute gastroenteritis is a very common infectious disease facing all age groups world...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Acute gastroenteritis is a very common infectious disease facing all age groups worldwide, especially the pediatric population. Viruses, bacteria, and parasites are all possible causes of infectious gastroenteritis; however, viruses have become more frequently identified with the advances in the ability to diagnose viral infections, particularly rotavirus and adenovirus. We aimed in our study to compare between the prevalence, risk factors, and clinical characteristics of rotavirus and adenovirus among children with viral gastroenteritis in Lebanon. Materials and methods: A 12-months retrospective study was performed between January 1 st and December 31 st , 2018 including 308 children aged 1 month to 12 years, who were admitted to three tertiary healthcare centers in South Lebanon. Medical data were retrieved from patients' files, including clinical and laboratory information. Results: Rotavirus was found in stool of 204 patients (66.23 %), followed by adenovirus in 78 cases (25.32 %), and mixed group (rotavirus and adenovirus) in 26 cases (8.44%). The highest prevalence of rotavirus in our present study was seen among children between 12 and 23 months old, whereas patients infected with adenovirus were mainly aged between 24-35 months or 4-11 months. Majority of patients in the adenovirus and mixed groups had high-grade fever compared to the rotavirus group. Laboratory findings presented significantly higher average of white blood cells (WBCs), absolute neutrophil count (ANC), and C-reactive protein (CRP) in the mixed group compared to the two other groups. Monthly distribution of rotavirus and adenovirus infection revealed a biennial pattern of rotavirus incidence during January and July-August while frequency of adenovirus infection was highest during July-August. Conclusion: Due to the high prevalence of viral diarrhea among the pediatric age group in our region, particularly rotavirus and adenovirus, along with the associated non-specific signs and symptoms, we highly recommend that medical laboratories be equipped for virus detection. Also, vaccination against rotavirus should be considered as a prevention strategy.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7d429d42fc3d12f27ef403c001195f33" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":82008262,"asset_id":73514881,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/82008262/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73514881"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73514881"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73514881; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73514881]").text(description); $(".js-view-count[data-work-id=73514881]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73514881; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73514881']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7d429d42fc3d12f27ef403c001195f33" } } $('.js-work-strip[data-work-id=73514881]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73514881,"title":"Prevalence, risk factors, and clinical characteristics of rotavirus and adenovirus among Lebanese hospitalized children with acute gastroenteritis","internal_url":"https://www.academia.edu/73514881/Prevalence_risk_factors_and_clinical_characteristics_of_rotavirus_and_adenovirus_among_Lebanese_hospitalized_children_with_acute_gastroenteritis","owner_id":160895526,"coauthors_can_edit":true,"owner":{"id":160895526,"first_name":"Ali","middle_initials":null,"last_name":"El Roz","page_name":"AliElRoz","domain_name":"independent","created_at":"2020-06-11T23:06:32.079-07:00","display_name":"Ali El Roz","url":"https://independent.academia.edu/AliElRoz"},"attachments":[{"id":82008262,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/82008262/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/82008262/download_file","bulk_download_file_name":"Prevalence_risk_factors_and_clinical_cha.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/82008262/ptpmcrender-libre.pdf?1646983271=\u0026response-content-disposition=attachment%3B+filename%3DPrevalence_risk_factors_and_clinical_cha.pdf\u0026Expires=1740530416\u0026Signature=ekXd01kuCnshl-fb000Kd-2m~mFyWqjUBX-3TigZxKgLdZL9033E2va5SE9V5n68HRNh6kkUPD7EYTRXC4cbAi83eoFWQhHglZCoNVw0hmPkvkjcTLJPNGl9-SKA6NcYunK98vxWJC9fbEBEb8WS5X6wBsXwEhxXV35qmpAeda1vmWmWsFwcEaQ00eB9K7FDlUYhXfEZkq9Q~LGyFcYkkv-IynuSVxkyJ0fCH3xYz62znn4I3bwxByBqki~o0f3wmBmR8bpJevmAw~lNRdn45ATv5QkKrUcoNBqD90zQbUUWQ~ki8GGP5107UTbl5ayvliaQ5laYpOJXKBqrLHzGvA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73514880"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73514880/Emergence_of_Vulvovaginal_Candidiasis_among_Lebanese_Pregnant_Women_Prevalence_Risk_Factors_and_Species_Distribution"><img alt="Research paper thumbnail of Emergence of Vulvovaginal Candidiasis among Lebanese Pregnant Women: Prevalence, Risk Factors, and Species Distribution" class="work-thumbnail" src="https://attachments.academia-assets.com/82008233/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73514880/Emergence_of_Vulvovaginal_Candidiasis_among_Lebanese_Pregnant_Women_Prevalence_Risk_Factors_and_Species_Distribution">Emergence of Vulvovaginal Candidiasis among Lebanese Pregnant Women: Prevalence, Risk Factors, and Species Distribution</a></div><div class="wp-workCard_item"><span>Infectious Diseases in Obstetrics and Gynecology</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objective. Candida species colonize the vagina in at least 20% of women, with rates rising to 30%...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objective. Candida species colonize the vagina in at least 20% of women, with rates rising to 30% during pregnancy. This study aimed at determining the prevalence and risk factors of vulvovaginal candidiasis (VVC) in pregnant women at 35-37 weeks of gestation. It also aims at finding possible correlations between VVC and vaginal colonization by other agents, such as Group B Streptococcus (GBS) and bacterial vaginosis. Methodology. Over a one-year period, high vaginal swabs were collected from pregnant women during their regular antenatal checkup in different polyclinics in Beirut and South Lebanon. Swabs were examined microscopically, cultured on Sabouraud Dextrose Agar, and Candida isolates were identified using Chromatic Candida medium and Germ Tube Test. Results. VVC was detected in 44.8% of samples, with C. glabrata (44.4%) and C. albicans (43.4%) being the most isolated species. Approximately, half of pregnant women (57.7%) were coinfected with Candida and bacterial vaginosis, ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8c524524fb073adebc3da4f307f0eeff" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":82008233,"asset_id":73514880,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/82008233/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73514880"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73514880"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73514880; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8c524524fb073adebc3da4f307f0eeff" } } $('.js-work-strip[data-work-id=73514880]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73514880,"title":"Emergence of Vulvovaginal Candidiasis among Lebanese Pregnant Women: Prevalence, Risk Factors, and Species Distribution","internal_url":"https://www.academia.edu/73514880/Emergence_of_Vulvovaginal_Candidiasis_among_Lebanese_Pregnant_Women_Prevalence_Risk_Factors_and_Species_Distribution","owner_id":160895526,"coauthors_can_edit":true,"owner":{"id":160895526,"first_name":"Ali","middle_initials":null,"last_name":"El Roz","page_name":"AliElRoz","domain_name":"independent","created_at":"2020-06-11T23:06:32.079-07:00","display_name":"Ali El Roz","url":"https://independent.academia.edu/AliElRoz"},"attachments":[{"id":82008233,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/82008233/thumbnails/1.jpg","file_name":"5016810.pdf","download_url":"https://www.academia.edu/attachments/82008233/download_file","bulk_download_file_name":"Emergence_of_Vulvovaginal_Candidiasis_am.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/82008233/5016810-libre.pdf?1646983274=\u0026response-content-disposition=attachment%3B+filename%3DEmergence_of_Vulvovaginal_Candidiasis_am.pdf\u0026Expires=1740530416\u0026Signature=dTf85JgN4qgl3b9U-8L0TwOiIBKJhSja9wvOZO8AFfwHgEbbikEIAtdn3IRInFw68ZGd0BJDFjaTcThK06t2lpn3pdwFqMGEJB13iHtByMvFvDZqkFo0grF0iOgzo3GhxYtJdn437WLqOikYiSjp5j9kqdXeIhFrH8Pe3kt0m2KQuTCFajqAZ945qu3QgicNRoOXDqxzrzKNjeA~oYUlG5aohz1fncHK7lT9zieJfTNQiytt2h2QeFzsPwF6K7EPP9QbGvgRr1tXvU~BLokhqdypbf95tAqvccIDSNAkTcO6GNMjB3X40h8Ql72bV~C2~0oi-SDwF3s4MZFmwjvyNA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":82008232,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/82008232/thumbnails/1.jpg","file_name":"5016810.pdf","download_url":"https://www.academia.edu/attachments/82008232/download_file","bulk_download_file_name":"Emergence_of_Vulvovaginal_Candidiasis_am.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/82008232/5016810-libre.pdf?1646983274=\u0026response-content-disposition=attachment%3B+filename%3DEmergence_of_Vulvovaginal_Candidiasis_am.pdf\u0026Expires=1740530416\u0026Signature=JomJ3fGGi6w4GsDsLBBbfEQMtoUpLhazULogbkMSgeRSSEV1x2YnqtPh6dprphdOzv1dUzCRD533g2U0aQO7~Fz-j1AGbHXHum1WuP7XwIUXfpYbTGZdnIUe1seWStY1p-5BRp7ghP4I-41zTeMGBTWwOCM8clED9hz9LHltDDInr3JfeUm-WStaCQBh3Hw-l0iT1RWKrkV1KF7tmKEeDMpu-fql5kVqaByXKIyBa2FtJkaLzQwNisGvbgaddLSMjgLr~giLDkK6o401vHY4JNmPMy6r21FwPy-zHyseDBhEOIck91rf3rRgU65JJdNJFlYckSJkIfUVdC0a8UjatA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73514879"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/73514879/Macrophage_apolipoprotein_E_and_proliferation_of_breast_cancer_cells_MCF_7_Role_of_LXR"><img alt="Research paper thumbnail of Macrophage apolipoprotein E and proliferation of breast cancer cells MCF-7: Role of LXR" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/73514879/Macrophage_apolipoprotein_E_and_proliferation_of_breast_cancer_cells_MCF_7_Role_of_LXR">Macrophage apolipoprotein E and proliferation of breast cancer cells MCF-7: Role of LXR</a></div><div class="wp-workCard_item"><span>The Faseb Journal</span><span>, Apr 1, 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Apolipoprotein E (APOE), a lipid transport protein that has a key role in the lipoprotein metabol...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Apolipoprotein E (APOE), a lipid transport protein that has a key role in the lipoprotein metabolism, is expressed by macrophages under the control of the transcription factor Liver X Receptor (LXR), an oxysterol-activated transcriptional factor involved in cholesterol metabolism. Recent work has shown that LXR agonists may inhibit breast cancer cell proliferation in vitro. We hypothesized that LXR-activated macrophages, and in particular secreted macrophagic APOE, may potentiate the effect of LXR agonists. Our goal was to evaluate the effect of APOE, secreted by THP-1 macrophages under the control of LXR, on MCF-7 cell proliferation, a model of breast cancer. MCF-7 cells were incubated with supernatants from THP-1 cells previously treated with LXR agonists [T0901317 or 22(R)-hydroxycholestrol], or supernatants from THP-1 cells transfected with siRNA against APOE mRNA. Viability assays and cell death quantification showed that media from LXR-activated macrophages reduced cell proliferation and increased apoptosis of MCF-7 cells. Interestingly, the opposite effects were observed when MCF-7 cells wre treated with media from the siRNA APOE-mediated knock-down model. This study highlights the protective role of LXR-activated macrophages against breast cancer growth, and the implication of APOE protein in the anti-proliferative and pro-apoptotic effects observed.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73514879"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73514879"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73514879; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); 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Recent work has shown that LXR agonists may inhibit breast cancer cell proliferation in vitro. We hypothesized that LXR-activated macrophages, and in particular secreted macrophagic APOE, may potentiate the effect of LXR agonists. Our goal was to evaluate the effect of APOE, secreted by THP-1 macrophages under the control of LXR, on MCF-7 cell proliferation, a model of breast cancer. MCF-7 cells were incubated with supernatants from THP-1 cells previously treated with LXR agonists [T0901317 or 22(R)-hydroxycholestrol], or supernatants from THP-1 cells transfected with siRNA against APOE mRNA. Viability assays and cell death quantification showed that media from LXR-activated macrophages reduced cell prolif...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2141aaf1fb81c0f81a571fe8884e2720" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":82008263,"asset_id":73514878,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/82008263/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73514878"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73514878"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73514878; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73514877"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/73514877/LXR_agonists_and_ABCG1_dependent_cholesterol_efflux_in_MCF_7_breast_cancer_cells_relation_to_proliferation_and_apoptosis"><img alt="Research paper thumbnail of LXR agonists and ABCG1-dependent cholesterol efflux in MCF-7 breast cancer cells: relation to proliferation and apoptosis" class="work-thumbnail" src="https://attachments.academia-assets.com/82008261/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73514877/LXR_agonists_and_ABCG1_dependent_cholesterol_efflux_in_MCF_7_breast_cancer_cells_relation_to_proliferation_and_apoptosis">LXR agonists and ABCG1-dependent cholesterol efflux in MCF-7 breast cancer cells: relation to proliferation and apoptosis</a></div><div class="wp-workCard_item"><span>Anticancer research</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Liver X receptor (LXR) plays a key role in reverse cholesterol transport by inducing the expressi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Liver X receptor (LXR) plays a key role in reverse cholesterol transport by inducing the expression of the ATP-binding cassette (ABC) transporters, implicated in cholesterol efflux. Recent data showed that LXR agonists inhibit the proliferation of multiple types of human cancer cells. However, whether these effects are related to cholesterol efflux has not yet been elucidated. Effects of two LXR agonists (TO901317 and 22(R)-hydroxycholesterol [22(R)-HC]) on proliferation, apoptosis and cholesterol efflux were examined in MCF-7 breast cancer cells. Treatment with LXR agonists (TO901317 at 20 渭M and 22(R)-HC at 2 渭g/ml) inhibited proliferation and induced apoptosis of MCF-7 cells. Furthermore, LXR activation resulted in an increase in gene and protein levels of ABCG1 transporters and in cholesterol efflux to isolated high-density lipoprotein (HDL), without affecting the ABCA1/APOA-I mediated efflux. Under these conditions, a remarkable reduction of intracellular and membrane-associate...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="61e9a00ffa38241a7a26bfeef6885649" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":82008261,"asset_id":73514877,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/82008261/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73514877"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73514877"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73514877; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73514876"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/73514876/P150_L_effet_antiprolif%C3%A9ratif_de_l_isom%C3%A8re_trans9_trans11_de_l_acide_linol%C3%A9ique_conjugu%C3%A9_sur_les_cellules_du_cancer_du_sein_MCF_7_est_associ%C3%A9_%C3%A0_une_activation_du_facteur_nucl%C3%A9aire_LXR"><img alt="Research paper thumbnail of P150 L鈥檈ffet antiprolif茅ratif de l鈥檌som猫re trans9, trans11 de l鈥檃cide linol茅ique conjugu茅 sur les cellules du cancer du sein MCF-7 est associ茅脿 une activation du facteur nucl茅aire LXR" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/73514876/P150_L_effet_antiprolif%C3%A9ratif_de_l_isom%C3%A8re_trans9_trans11_de_l_acide_linol%C3%A9ique_conjugu%C3%A9_sur_les_cellules_du_cancer_du_sein_MCF_7_est_associ%C3%A9_%C3%A0_une_activation_du_facteur_nucl%C3%A9aire_LXR">P150 L鈥檈ffet antiprolif茅ratif de l鈥檌som猫re trans9, trans11 de l鈥檃cide linol茅ique conjugu茅 sur les cellules du cancer du sein MCF-7 est associ茅脿 une activation du facteur nucl茅aire LXR</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ABSTRACT Introduction et but de l&amp;#39;茅tude: Liver X Receptor (LXR) est un facteur nucl茅aire ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ABSTRACT Introduction et but de l&amp;#39;茅tude: Liver X Receptor (LXR) est un facteur nucl茅aire qui a un r么le dans le transport inverse du cholest茅rol, permettant le retour de ce lipide des tissus p茅riph茅riques vers le foie. Des travaux r茅cents sugg猫rent que LXR est impliqu茅 dans l&amp;#39;inhibition de la croissance des tumeurs. Les acides linol茅iques conjugu茅s (CLA), dont le pouvoir anti-tumoral est bien document茅, sont des acides gras pr茅sents dans les aliments d鈥檕rigine animale comme la viande de ruminants ou certains produits laitiers, et peuvent 茅galement 锚tre g茅n茅r茅s sous l鈥檃ction de la flore bact茅rienne intestinale. Certains isom猫res CLA, qui se distinguent par la g茅om茅trie cis (c) ou trans (t), et par le positionnement des doubles liaisons sur la cha卯ne carbon茅e, ont r茅cemment 茅t茅 pr茅sent茅s comme activateurs potentiels de LXR. L鈥檕bjectif de l鈥櫭﹖ude est d鈥櫭﹙aluer l鈥檈ffet de plusieurs isom猫res CLA sur la prolif茅ration et l鈥檃poptose d鈥檜ne lign茅e humaine de cancer du sein (MCF-7), et v茅rifier leur capacit茅脿 activer les g猫nes cibles de LXR. Mat茅riel et M茅thodes: Des tests MTT ont permis d鈥櫭﹙aluer le taux de prolif茅ration des cellules MCF-7 trait茅es pendant 24 heures avec 3 isom猫res CLA (c9,t11 ; t9,t11 et t10,c12). La mort cellulaire a 茅t茅 quantifi茅e par un marquage en cytom茅trie de flux par le fluorophore 7-AAD, qui se lie sur l鈥橝DN des cellules mortes. Enfin, le taux d鈥檈xpression des g猫nes et prot茅ines impliqu茅s dans l鈥檃poptose ainsi que des cibles de LXR, est analys茅 en qPCR et en Western Blot. R茅sultats: Les r茅sultats montrent que l鈥檌som猫re t9,t11-CLA a une efficacit茅 d鈥檌nhibition de la prolif茅ration et d鈥檌nduction d鈥檃poptose des cellules MCF-7 qui est bien sup茅rieure que celle des deux autres isom猫res test茅s. Ainsi, le t9,t11-CLA diminue la prolif茅ration des cellules MCF-7 de 50 % et induit une augmentation significative de l鈥檃poptose apr猫s 24h de traitement. En outre, les r茅sultats obtenus en qPCR montrent que cet isom猫re induit l鈥檈xpression du g猫ne proapoptotique BAX et inhibe celle du g猫ne anti-apoptotique Bcl-2. De plus, le traitement avec le t9,t11-CLA induit une alt茅ration de la morphologie cellulaire marqu茅e par l鈥檃pparition du ph茅nom猫ne de 芦 cell membrane blebbing 禄 qui caract茅rise les cellules apoptotiques. Nos r茅sultats en qPCR et en Western Blot montrent que l鈥檌som猫re t9,t11-CLA induit l鈥檈xpression de ABCA1, ABCG1 et ARL7, qui sont des cibles du facteur LXR et sont tous impliqu茅s dans l鈥檈fflux du cholest茅rol. Conclusion: Le pouvoir anti-tumoral des CLA est bien document茅. Cependant, le r么le individuel des isom猫res de CLA reste controvers茅 puisque la plupart des 茅tudes ont utilis茅 des m茅langes d鈥檌som猫res. Ici nous montrons que l鈥檌som猫re t9,t11-CLA a un effet anti-prolif茅ratif qui est sup茅rieur 脿 celui de deux autres isom猫res test茅s. Les r茅sultats obtenus montrent qu鈥檌l induit 茅galement l鈥檈xpression des g猫nes cibles de LXR, confirmant des r茅sultats r茅cents obtenus sur une lign茅e macrophagique. L鈥檃ctivation de LXR pourrait conduire 脿 priver les cellules canc茅reuses des lipides indispensables 脿 leur croissance en stimulant l鈥檈fflux du cholest茅rol. Il para卯t n茅cessaire de v茅rifier l鈥檌nt茅r锚t de la suppl茅mentation en CLA, agonistes de LXR, pour ralentir la progression de la maladie dans des mod猫les animaux de cancer du sein.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73514876"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73514876"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73514876; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73514875"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/73514875/The_anti_proliferative_and_pro_apoptotic_effects_of_the_trans9_trans11_conjugated_linoleic_acid_isomer_on_MCF_7_breast_cancer_cells_are_associated_with_LXR_activation"><img alt="Research paper thumbnail of The anti-proliferative and pro-apoptotic effects of the trans9,trans11 conjugated linoleic acid isomer on MCF-7 breast cancer cells are associated with LXR activation" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/73514875/The_anti_proliferative_and_pro_apoptotic_effects_of_the_trans9_trans11_conjugated_linoleic_acid_isomer_on_MCF_7_breast_cancer_cells_are_associated_with_LXR_activation">The anti-proliferative and pro-apoptotic effects of the trans9,trans11 conjugated linoleic acid isomer on MCF-7 breast cancer cells are associated with LXR activation</a></div><div class="wp-workCard_item"><span>Prostaglandins, Leukotrienes and Essential Fatty Acids</span><span>, 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Conjugated linoleic acids (CLA), naturally found in dairy products and ruminant meat, are positio...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Conjugated linoleic acids (CLA), naturally found in dairy products and ruminant meat, are positional and geometric isomers (trans: t or cis: c) of linoleic acid, and have been widely reported to possess anti-tumoral activity against breast cancer both in vitro and in vivo. CLA isomer t9,t11 was recently proposed as an agonist of the transcriptional factor LXR, which is known for inducing genes implicated in cholesterol efflux. In this study, the growth inhibitory effect of three CLA isomers (c9,t11-CLA, t9,t11-CLA and t10,c12-CLA) was investigated on MCF-7 breast cancer cells, as well as their effect on LXR target genes. Our results revealed that t9,t11-CLA was the most efficient isomer by decreasing MCF-7 proliferation, inhibiting migration, and inducing apoptosis after 24h of treatment. t9,t11-CLA treatment led to an increase in the mRNA levels of LXR target genes involved in cholesterol efflux (ABCG1 and ARL7), as well as an increase of HMG-CoA-reductase which is the rate-limiting step of cholesterol biosynthesis. Interestingly, confocal microscopy analysis showed that t9,t11-CLA treatment remarkably reduced the intracellular and membrane-associated cholesterol levels. LXR activation through t9,t11-CLA isomer could lead to cholesterol cell deprivation by stimulating its efflux, which results in the inhibition of cell proliferation and stimulation of apoptosis.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73514875"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73514875"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73514875; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); 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