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class="interlanguage-link interwiki-bs mw-list-item"><a href="https://bs.wikipedia.org/wiki/Monooksigenaza" title="Monooksigenaza – Bosnian" lang="bs" hreflang="bs" data-title="Monooksigenaza" data-language-autonym="Bosanski" data-language-local-name="Bosnian" class="interlanguage-link-target"><span>Bosanski</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Monooxigenasa" title="Monooxigenasa – Catalan" lang="ca" hreflang="ca" data-title="Monooxigenasa" data-language-autonym="Català" data-language-local-name="Catalan" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Monooxigenasa" title="Monooxigenasa – Spanish" lang="es" hreflang="es" data-title="Monooxigenasa" data-language-autonym="Español" data-language-local-name="Spanish" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link 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.infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox"><tbody><tr><th colspan="2" class="infobox-above">Monooxygenase</th></tr><tr><td colspan="2" class="infobox-image"><span class="mw-default-size" typeof="mw:File/Frameless"><a href="/wiki/File:2Y6Q.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/9/9d/2Y6Q.jpg/220px-2Y6Q.jpg" decoding="async" width="220" height="175" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/9d/2Y6Q.jpg/330px-2Y6Q.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/9d/2Y6Q.jpg/440px-2Y6Q.jpg 2x" data-file-width="764" data-file-height="609" /></a></span><div class="infobox-caption">Structure of the TetX monooxygenase in complex with the substrate 7-Iodtetracycline.<sup id="cite_ref-pmid21402075_1-0" class="reference"><a href="#cite_note-pmid21402075-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></div></td></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3">Symbol</th><td class="infobox-data" style="background-color: #eee">FAD_binding_3</td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Pfam" title="Pfam">Pfam</a></th><td class="infobox-data pfam" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/interpro/entry/pfam/PF01494">PF01494</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/InterPro" title="InterPro">InterPro</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/interpro/entry/IPR002938">IPR002938</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Structural_Classification_of_Proteins" class="mw-redirect" title="Structural Classification of Proteins">SCOP2</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="http://scop2.mrc-lmb.cam.ac.uk/search?t=txt;q=2phh">2phh</a> / <a rel="nofollow" class="external text" href="https://scop.berkeley.edu/pdb/code=2phh">SCOPe</a> / <a rel="nofollow" class="external text" href="http://supfam.org/SUPERFAMILY/cgi-bin/search.cgi?search_field=2phh">SUPFAM</a></td></tr><tr><td colspan="2" class="infobox-full-data" style="background-color: #eee"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><table class="infobox mw-collapsible mw-collapsed" style="float:none; clear:none; margin:0; border-width:0; border-collapse:collapse; text-align:left; width:100%"><tbody><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Available protein structures:</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/Pfam" title="Pfam">Pfam</a>  </th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="http://pfam.xfam.org/family/PF01494?tab=pdbBlock">structures</a> / <a rel="nofollow" class="external text" href="http://prodata.swmed.edu/ecod/complete/search?kw=PF01494">ECOD</a>  </td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_annotation.annotation_id:PF01494%20AND%20rcsb_polymer_entity_annotation.type:Pfam">RCSB PDB</a>; <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/entry/search/index?pfam_accession:PF01494">PDBe</a>; <a rel="nofollow" class="external text" href="https://pdbj.org/search/pdb?other_db_select=PFam&other_db_field=PF01494">PDBj</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/PDBsum" title="PDBsum">PDBsum</a></th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPfamStr.pl?pfam_id=PF01494">structure summary</a></td></tr></tbody></table></td></tr></tbody></table> <p><b>Monooxygenases</b> are enzymes that incorporate one <a href="/wiki/Hydroxyl_group" class="mw-redirect" title="Hydroxyl group">hydroxyl group</a> (−OH) into substrates in many metabolic pathways. In this reaction, the two atoms of <a href="/wiki/Dioxygen" class="mw-redirect" title="Dioxygen">dioxygen</a> are reduced to one <a href="/wiki/Hydroxyl_group" class="mw-redirect" title="Hydroxyl group">hydroxyl group</a> and one H<sub>2</sub>O molecule by the concomitant oxidation of <a href="/wiki/NAD(P)H" class="mw-redirect" title="NAD(P)H">NAD(P)H</a>.<sup id="cite_ref-PUB00000123_2-0" class="reference"><a href="#cite_note-PUB00000123-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-PUB00006431_3-0" class="reference"><a href="#cite_note-PUB00006431-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> One important subset of the monooxygenases, the <a href="/wiki/Cytochrome_P450_omega_hydroxylase" title="Cytochrome P450 omega hydroxylase">cytochrome P450 omega hydroxylases</a>, is used by cells to metabolize arachidonic acid (i.e. eicosatetraenoic acid) to the <a href="/wiki/Cell_signaling" title="Cell signaling">cell signaling</a> molecules, <a href="/wiki/20-hydroxyeicosatetraenoic_acid" class="mw-redirect" title="20-hydroxyeicosatetraenoic acid">20-hydroxyeicosatetraenoic acid</a> or to reduce or totally inactivate the activate signaling molecules for example by hydroxylating <a href="/wiki/Leukotriene_B4" title="Leukotriene B4">leukotriene B4</a> to 20-hydroxy-leukotriene B5, <a href="/wiki/5-hydroxyeicosatetraenoic_acid" class="mw-redirect" title="5-hydroxyeicosatetraenoic acid">5-hydroxyeicosatetraenoic acid</a> to 5,20-dihydroxyeicosatetraenoic acid, <a href="/wiki/5-oxo-eicosatetraenoic_acid" class="mw-redirect" title="5-oxo-eicosatetraenoic acid">5-oxo-eicosatetraenoic acid</a> to 5-oxo-20-hydroxyeicosatetraenoic acid, <a href="/wiki/12-hydroxyeicosatetraenoic_acid" class="mw-redirect" title="12-hydroxyeicosatetraenoic acid">12-hydroxyeicosatetraenoic acid</a> to 12,20-dihydroxyeicosatetraenoic acid, and <a href="/wiki/Epoxyeicosatrienoic_acid" title="Epoxyeicosatrienoic acid">epoxyeicosatrienoic acids</a> to 20-hydroxy-epoxyeicosatrienoic acids. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Classification">Classification</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Monooxygenase&action=edit&section=1" title="Edit section: Classification"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>They are classified as <a href="/wiki/Oxidoreductase" title="Oxidoreductase">oxidoreductase</a> enzymes that catalyze an electron transfer. </p> <div class="mw-heading mw-heading2"><h2 id="Related_structures">Related structures</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Monooxygenase&action=edit&section=2" title="Edit section: Related structures"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><a rel="nofollow" class="external text" href="http://www.pdb.org/pdb/explore/explore.do?structureId=2XDO">2XDO</a> <a rel="nofollow" class="external text" href="http://www.pdb.org/pdb/explore/explore.do?structureId=2XYO">2XYO</a> <a rel="nofollow" class="external text" href="http://www.pdb.org/pdb/explore/explore.do?structureId=2Y6R">2Y6R</a> </p> <div class="mw-heading mw-heading2"><h2 id="Human_proteins_containing_this_domain">Human proteins containing this domain</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Monooxygenase&action=edit&section=3" title="Edit section: Human proteins containing this domain"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><a href="/wiki/COQ6" title="COQ6">COQ6</a>; <a href="/wiki/CYP450" class="mw-redirect" title="CYP450">CYP450</a>; <a href="/wiki/MICAL1" title="MICAL1">MICAL1</a>; <a href="/wiki/MICAL2" title="MICAL2">MICAL2</a>; <a href="/w/index.php?title=MICAL2PV1&action=edit&redlink=1" class="new" title="MICAL2PV1 (page does not exist)">MICAL2PV1</a>; <a href="/w/index.php?title=MICAL2PV2&action=edit&redlink=1" class="new" title="MICAL2PV2 (page does not exist)">MICAL2PV2</a>; <a href="/wiki/MICAL3" title="MICAL3">MICAL3</a>; </p> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Monooxygenase&action=edit&section=4" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/ABM_domain" title="ABM domain">ABM domain</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Monooxygenase&action=edit&section=5" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-pmid21402075-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid21402075_1-0">^</a></b></span> <span class="reference-text"><span class="plainlinks"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a>: <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2Y6Q">2Y6Q</a></span>; <style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite id="CITEREFVolkersPalmWeissWright2011" class="citation journal cs1">Volkers G, Palm GJ, Weiss MS, Wright GD, Hinrichs W (April 2011). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.febslet.2011.03.012">"Structural basis for a new tetracycline resistance mechanism relying on the TetX monooxygenase"</a>. <i>FEBS Lett</i>. <b>585</b> (7): 1061–6. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.febslet.2011.03.012">10.1016/j.febslet.2011.03.012</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/21402075">21402075</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:26967337">26967337</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=FEBS+Lett.&rft.atitle=Structural+basis+for+a+new+tetracycline+resistance+mechanism+relying+on+the+TetX+monooxygenase&rft.volume=585&rft.issue=7&rft.pages=1061-6&rft.date=2011-04&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A26967337%23id-name%3DS2CID&rft_id=info%3Apmid%2F21402075&rft_id=info%3Adoi%2F10.1016%2Fj.febslet.2011.03.012&rft.aulast=Volkers&rft.aufirst=G&rft.au=Palm%2C+GJ&rft.au=Weiss%2C+MS&rft.au=Wright%2C+GD&rft.au=Hinrichs%2C+W&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252Fj.febslet.2011.03.012&rfr_id=info%3Asid%2Fen.wikipedia.org%3AMonooxygenase" class="Z3988"></span></span> </li> <li id="cite_note-PUB00000123-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-PUB00000123_2-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHarayamaKokNeidle1992" class="citation journal cs1">Harayama S, Kok M, Neidle EL (1992). "Functional and evolutionary relationships among diverse oxygenases". <i>Annu. Rev. Microbiol</i>. <b>46</b>: 565–601. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1146%2Fannurev.mi.46.100192.003025">10.1146/annurev.mi.46.100192.003025</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/1444267">1444267</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Annu.+Rev.+Microbiol.&rft.atitle=Functional+and+evolutionary+relationships+among+diverse+oxygenases&rft.volume=46&rft.pages=565-601&rft.date=1992&rft_id=info%3Adoi%2F10.1146%2Fannurev.mi.46.100192.003025&rft_id=info%3Apmid%2F1444267&rft.aulast=Harayama&rft.aufirst=S&rft.au=Kok%2C+M&rft.au=Neidle%2C+EL&rfr_id=info%3Asid%2Fen.wikipedia.org%3AMonooxygenase" class="Z3988"></span></span> </li> <li id="cite_note-PUB00006431-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-PUB00006431_3-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSchreudervan_BerkelEppinkBunthol1999" class="citation journal cs1">Schreuder HA, van Berkel WJ, Eppink MH, Bunthol C (1999). "Phe161 and Arg166 variants of p-hydroxybenzoate hydroxylase. Implications for NADPH recognition and structural stability". <i>FEBS Lett</i>. <b>443</b> (3): 251–255. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0014-5793%2898%2901726-8">10.1016/S0014-5793(98)01726-8</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10025942">10025942</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:21305517">21305517</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=FEBS+Lett.&rft.atitle=Phe161+and+Arg166+variants+of+p-hydroxybenzoate+hydroxylase.+Implications+for+NADPH+recognition+and+structural+stability&rft.volume=443&rft.issue=3&rft.pages=251-255&rft.date=1999&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A21305517%23id-name%3DS2CID&rft_id=info%3Apmid%2F10025942&rft_id=info%3Adoi%2F10.1016%2FS0014-5793%2898%2901726-8&rft.aulast=Schreuder&rft.aufirst=HA&rft.au=van+Berkel%2C+WJ&rft.au=Eppink%2C+MH&rft.au=Bunthol%2C+C&rfr_id=info%3Asid%2Fen.wikipedia.org%3AMonooxygenase" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Monooxygenase&action=edit&section=6" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><span class="noviewer" typeof="mw:File"><a href="/wiki/File:Commons-logo.svg" class="mw-file-description"><img alt="" src="//upload.wikimedia.org/wikipedia/en/thumb/4/4a/Commons-logo.svg/12px-Commons-logo.svg.png" decoding="async" width="12" height="16" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/4/4a/Commons-logo.svg/18px-Commons-logo.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/4/4a/Commons-logo.svg/24px-Commons-logo.svg.png 2x" data-file-width="1024" data-file-height="1376" /></a></span> Media related to <a href="https://commons.wikimedia.org/wiki/Category:Monooxygenases" class="extiw" title="commons:Category:Monooxygenases">Monooxygenases</a> at Wikimedia Commons</li></ul> <div role="note" style="font-style: italic;">This article incorporates text from the public domain <a href="/wiki/Pfam" title="Pfam">Pfam</a> and <a href="/wiki/InterPro" title="InterPro">InterPro</a>: <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/interpro/entry/IPR002938">IPR002938</a></div> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline ul,.mw-parser-output .hlist dl dl,.mw-parser-output .hlist dl ol,.mw-parser-output .hlist dl ul,.mw-parser-output .hlist ol dl,.mw-parser-output .hlist ol ol,.mw-parser-output .hlist ol ul,.mw-parser-output .hlist ul dl,.mw-parser-output .hlist ul ol,.mw-parser-output .hlist ul ul{display:inline}.mw-parser-output .hlist .mw-empty-li{display:none}.mw-parser-output .hlist dt::after{content:": "}.mw-parser-output .hlist dd::after,.mw-parser-output .hlist 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scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><style data-mw-deduplicate="TemplateStyles:r1239400231">.mw-parser-output .navbar{display:inline;font-size:88%;font-weight:normal}.mw-parser-output .navbar-collapse{float:left;text-align:left}.mw-parser-output .navbar-boxtext{word-spacing:0}.mw-parser-output .navbar ul{display:inline-block;white-space:nowrap;line-height:inherit}.mw-parser-output .navbar-brackets::before{margin-right:-0.125em;content:"[ "}.mw-parser-output .navbar-brackets::after{margin-left:-0.125em;content:" ]"}.mw-parser-output .navbar li{word-spacing:-0.125em}.mw-parser-output .navbar a>span,.mw-parser-output .navbar a>abbr{text-decoration:inherit}.mw-parser-output .navbar-mini abbr{font-variant:small-caps;border-bottom:none;text-decoration:none;cursor:inherit}.mw-parser-output .navbar-ct-full{font-size:114%;margin:0 7em}.mw-parser-output .navbar-ct-mini{font-size:114%;margin:0 4em}html.skin-theme-clientpref-night .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}@media(prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}}@media print{.mw-parser-output .navbar{display:none!important}}</style><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Monooxygenases" title="Template:Monooxygenases"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Monooxygenases" title="Template talk:Monooxygenases"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Monooxygenases" title="Special:EditPage/Template:Monooxygenases"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Oxidoreductases:_monooxygenases_(EC_1.13)" style="font-size:114%;margin:0 4em"><a href="/wiki/Oxidoreductase" title="Oxidoreductase">Oxidoreductases</a>: <a href="/wiki/Oxygenase" title="Oxygenase">monooxygenases</a> (<a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC</a> 1.13)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_1)#EC_1.13.11_With_incorporation_of_two_atoms_of_oxygen" title="List of EC numbers (EC 1)">1.13.11</a>: two atoms of oxygen</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Lipoxygenase" title="Lipoxygenase">lipoxygenase</a>:</i> <a href="/wiki/Arachidonate_5-lipoxygenase" title="Arachidonate 5-lipoxygenase">Arachidonate 5-lipoxygenase</a></li> <li><a href="/wiki/Arachidonate_12-lipoxygenase" class="mw-redirect" title="Arachidonate 12-lipoxygenase">Arachidonate 12-lipoxygenase</a>/<a href="/wiki/ALOX12" title="ALOX12">ALOX12</a></li> <li><a href="/wiki/Arachidonate_8-lipoxygenase" title="Arachidonate 8-lipoxygenase">Arachidonate 8-lipoxygenase</a></li> <li><a href="/wiki/Arachidonate_15-lipoxygenase" class="mw-redirect" title="Arachidonate 15-lipoxygenase">Arachidonate 15-lipoxygenase</a>/<a href="/wiki/ALOX15" title="ALOX15">ALOX15</a></li> <li><a href="/wiki/Linoleate_11-lipoxygenase" title="Linoleate 11-lipoxygenase">Linoleate 11-lipoxygenase</a></li></ul> <ul><li><i>other dioxygenase:</i> <a href="/wiki/Catechol_dioxygenase" title="Catechol dioxygenase">Catechol dioxygenase</a></li> <li><a href="/wiki/Homogentisate_1,2-dioxygenase" title="Homogentisate 1,2-dioxygenase">Homogentisate 1,2-dioxygenase</a></li> <li><a href="/wiki/Cysteine_dioxygenase" title="Cysteine dioxygenase">Cysteine dioxygenase</a></li> <li><a href="/wiki/4-Hydroxyphenylpyruvate_dioxygenase" title="4-Hydroxyphenylpyruvate dioxygenase">4-Hydroxyphenylpyruvate dioxygenase</a></li> <li><a href="/wiki/Indoleamine_2,3-dioxygenase" title="Indoleamine 2,3-dioxygenase">Indoleamine 2,3-dioxygenase</a></li> <li><a href="/wiki/Chlorite_dismutase" title="Chlorite dismutase">Chlorite dismutase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_1)#EC_1.13.12_With_incorporation_of_one_atom_of_oxygen_.28internal_monooxygenases_or_internal_mixed_function_oxidases.29" title="List of EC numbers (EC 1)">1.13.12</a>: one atom of oxygen</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Luciferase" title="Luciferase">Firefly luciferase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_1)#EC_1.13.99_Miscellaneous" title="List of EC numbers (EC 1)">1.13.99</a>: other</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Inositol_oxygenase" title="Inositol oxygenase">Inositol oxygenase</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Oxidoreductases:_dioxygenases,_including_steroid_hydroxylases_(EC_1.14)" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Dioxygenases" title="Template:Dioxygenases"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Dioxygenases" title="Template talk:Dioxygenases"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Dioxygenases" title="Special:EditPage/Template:Dioxygenases"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Oxidoreductases:_dioxygenases,_including_steroid_hydroxylases_(EC_1.14)" style="font-size:114%;margin:0 4em"><a href="/wiki/Oxidoreductase" title="Oxidoreductase">Oxidoreductases</a>: <a href="/wiki/Oxygenase" title="Oxygenase">dioxygenases</a>, including <a href="/wiki/Steroid_hydroxylases" class="mw-redirect" title="Steroid hydroxylases">steroid hydroxylases</a> (<a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC</a> 1.14)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_1)#EC_1.14.11_With_2-oxoglutarate_as_one_donor.2C_and_incorporation_of_one_atom_each_of_oxygen_into_both_donors" title="List of EC numbers (EC 1)">1.14.11</a>: <a href="/wiki/Alpha-Ketoglutaric_acid" class="mw-redirect" title="Alpha-Ketoglutaric acid">2-oxoglutarate</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Prolyl_hydroxylase" class="mw-redirect" title="Prolyl hydroxylase">Prolyl hydroxylase</a> <ul><li><a href="/wiki/HIF_prolyl-hydroxylase" class="mw-redirect" title="HIF prolyl-hydroxylase">HIF prolyl-hydroxylase</a> <ul><li><a href="/wiki/EGLN1" title="EGLN1">EGLN1</a></li> <li><a href="/wiki/EGLN2" title="EGLN2">EGLN2</a></li> <li><a href="/wiki/EGLN3" title="EGLN3">EGLN3</a></li></ul></li> <li><a href="/wiki/P4HTM" title="P4HTM">P4HTM</a></li></ul></li> <li><a href="/wiki/Lysyl_hydroxylase" title="Lysyl hydroxylase">Lysyl hydroxylase</a></li> <li><a href="/wiki/AlkB" title="AlkB">AlkB</a> <ul><li><a href="/wiki/Alkb_homolog_1,_histone_h2a_dioxygenase" title="Alkb homolog 1, histone h2a dioxygenase">ALKBH1</a></li> <li><a href="/wiki/FTO_gene" title="FTO gene">FTO</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_1)#EC_1.14.13_With_NADH_or_NADPH_as_one_donor.2C_and_incorporation_of_one_atom_of_oxygen" title="List of EC numbers (EC 1)">1.14.13</a>: <a href="/wiki/NADH" class="mw-redirect" title="NADH">NADH</a> or <a href="/wiki/NADPH" class="mw-redirect" title="NADPH">NADPH</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Flavin-containing_monooxygenase" title="Flavin-containing monooxygenase">Flavin-containing monooxygenase</a> <ul><li><a href="/wiki/FMO1" class="mw-redirect" title="FMO1">FMO1</a></li> <li><a href="/wiki/FMO2" title="FMO2">FMO2</a></li> <li><a href="/wiki/Flavin-containing_monooxygenase_3" title="Flavin-containing monooxygenase 3">FMO3</a></li> <li><a href="/wiki/FMO4" title="FMO4">FMO4</a></li> <li><a href="/wiki/FMO5" title="FMO5">FMO5</a></li></ul></li> <li><a href="/wiki/Nitric_oxide_synthase" title="Nitric oxide synthase">Nitric oxide synthase</a> <ul><li><a href="/wiki/NOS1" title="NOS1">NOS1</a></li> <li><a href="/wiki/Nitric_oxide_synthase_2_(inducible)" title="Nitric oxide synthase 2 (inducible)">NOS2</a></li> <li><a href="/wiki/Endothelial_NOS" title="Endothelial NOS">NOS3</a></li></ul></li> <li><a href="/wiki/Cholesterol_7_alpha-hydroxylase" title="Cholesterol 7 alpha-hydroxylase">Cholesterol 7 alpha-hydroxylase</a></li> <li><a href="/wiki/Methane_monooxygenase" title="Methane monooxygenase">Methane monooxygenase</a></li> <li><a href="/wiki/CYP3A4" title="CYP3A4">3A4</a></li> <li><a href="/wiki/14%CE%B1-demethylase" class="mw-redirect" title="14α-demethylase">14α-demethylase</a></li> <li><a href="/wiki/24-hydroxycholesterol_7alpha-hydroxylase" title="24-hydroxycholesterol 7alpha-hydroxylase">24-hydroxycholesterol 7α-hydroxylase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_1)#EC_1.14.14_With_reduced_flavin_or_flavoprotein_as_one_donor.2C_and_incorporation_of_one_atom_of_oxygen" title="List of EC numbers (EC 1)">1.14.14</a>: reduced <a href="/wiki/Flavin_group" title="Flavin group">flavin</a> or <a href="/wiki/Flavoprotein" title="Flavoprotein">flavoprotein</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Aromatase" title="Aromatase">19A1</a></li> <li><a href="/wiki/CYP2D6" title="CYP2D6">2D6</a></li> <li><a href="/wiki/CYP2E1" title="CYP2E1">2E1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_1)#EC_1.14.15_With_reduced_iron–sulfur_protein_as_one_donor.2C_and_incorporation_of_one_atom_of_oxygen" title="List of EC numbers (EC 1)">1.14.15</a>: reduced <a href="/wiki/Iron%E2%80%93sulfur_protein" title="Iron–sulfur protein">iron–sulfur protein</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Steroid_11-beta-hydroxylase" class="mw-redirect" title="Steroid 11-beta-hydroxylase">11B1</a></li> <li><a href="/wiki/Aldosterone_synthase" title="Aldosterone synthase">11B2</a></li> <li><a href="/wiki/Cholesterol_side-chain_cleavage_enzyme" title="Cholesterol side-chain cleavage enzyme">11A1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_1)#EC_1.14.16_With_reduced_pteridine_as_one_donor.2C_and_incorporation_of_one_atom_of_oxygen" title="List of EC numbers (EC 1)">1.14.16</a>: reduced <a href="/wiki/Pteridine" title="Pteridine">pteridine</a> (<a href="/wiki/Tetrahydrobiopterin" title="Tetrahydrobiopterin">BH4 dependent</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Phenylalanine_hydroxylase" title="Phenylalanine hydroxylase">Phenylalanine hydroxylase</a></li> <li><a href="/wiki/Tyrosine_hydroxylase" title="Tyrosine hydroxylase">Tyrosine hydroxylase</a></li> <li><a href="/wiki/Tryptophan_hydroxylase" title="Tryptophan hydroxylase">Tryptophan hydroxylase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_1)#EC_1.14.17_With_reduced_ascorbate_as_one_donor.2C_and_incorporation_of_one_atom_of_oxygen" title="List of EC numbers (EC 1)">1.14.17</a>: reduced <a href="/wiki/Ascorbate" class="mw-redirect" title="Ascorbate">ascorbate</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Dopamine_beta-hydroxylase" title="Dopamine beta-hydroxylase">Dopamine beta-hydroxylase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_1)#EC_1.14.18_With_another_compound_as_one_donor.2C_and_incorporation_of_one_atom_of_oxygen" title="List of EC numbers (EC 1)">1.14.18</a>-<a href="/wiki/List_of_EC_numbers_(EC_1)#EC_1.14.19_With_oxidation_of_a_pair_of_donors_resulting_in_the_reduction_of_molecular_oxygen_to_two_molecules_of_water" title="List of EC numbers (EC 1)">19</a>: other</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Tyrosinase" title="Tyrosinase">Tyrosinase</a></li> <li><a href="/wiki/Stearoyl-CoA_desaturase-1" class="mw-redirect" title="Stearoyl-CoA desaturase-1">Stearoyl-CoA desaturase-1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_1)#EC_1.14.99_Miscellaneous" title="List of EC numbers (EC 1)">1.14.99</a> - miscellaneous</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cyclooxygenase" title="Cyclooxygenase">Cyclooxygenase</a></li> <li><a href="/wiki/Heme_oxygenase" title="Heme oxygenase">Heme oxygenase</a> (<a href="/wiki/HMOX1" title="HMOX1">HMOX1</a>)</li> <li><a href="/wiki/Squalene_monooxygenase" title="Squalene monooxygenase">Squalene monooxygenase</a></li> <li><a href="/wiki/CYP17A1" title="CYP17A1">17A1</a></li> <li><a href="/wiki/21-Hydroxylase" title="21-Hydroxylase">21A2</a></li> <li><a href="/wiki/Ecdysone_20-monooxygenase" title="Ecdysone 20-monooxygenase">Ecdysone 20-monooxygenase</a></li> <li><a href="/wiki/Deoxyhypusine_monooxygenase" title="Deoxyhypusine monooxygenase">Deoxyhypusine monooxygenase</a></li></ul> </div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Retrieved from "<a dir="ltr" href="https://en.wikipedia.org/w/index.php?title=Monooxygenase&oldid=1170980511">https://en.wikipedia.org/w/index.php?title=Monooxygenase&oldid=1170980511</a>"</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Help:Category" title="Help:Category">Categories</a>: <ul><li><a href="/wiki/Category:Protein_domains" title="Category:Protein domains">Protein domains</a></li><li><a href="/wiki/Category:Enzymes" title="Category:Enzymes">Enzymes</a></li></ul></div><div id="mw-hidden-catlinks" class="mw-hidden-catlinks 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