Search results for: Swapnila V. Vanshiv

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Vanshiv</title> <meta name="description" content="Search results for: Swapnila V. Vanshiv"> <meta name="keywords" content="Swapnila V. Vanshiv"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" type="button" data-toggle="collapse" data-target="#navbarMenu" aria-controls="navbarMenu" aria-expanded="false" aria-label="Toggle navigation"> <span class="navbar-toggler-icon"></span> </button> <div class="w-100"> <div class="d-none d-lg-flex flex-row-reverse"> <form method="get" action="https://waset.org/search" class="form-inline my-2 my-lg-0"> <input class="form-control mr-sm-2" type="search" placeholder="Search Conferences" value="Swapnila V. 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Vanshiv"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 2</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: Swapnila V. Vanshiv</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Development, Optimization and Characterization of Gastroretentive Multiparticulate Drug Delivery System</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Swapnila%20V.%20Vanshiv">Swapnila V. Vanshiv</a>, <a href="https://publications.waset.org/abstracts/search?q=Hemant%20P.%20Joshi"> Hemant P. Joshi</a>, <a href="https://publications.waset.org/abstracts/search?q=Atul%20B.%20Aware"> Atul B. Aware</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Current study illustrates the formulation of floating microspheres for purpose of gastroretention of Dipyridamole which shows pH dependent solubility, with the highest solubility in acidic pH. The formulation involved hollow microsphere preparation by using solvent evaporation technique. Concentrations of rate controlling polymer, hydrophilic polymer, internal phase ratio, stirring speed were optimized to get desired responses, namely release of Dipyridamole, buoyancy of microspheres, entrapment efficiency of microspheres. In the formulation, the floating microspheres were prepared by using ethyl cellulose as release retardant and HPMC as a low density hydrophilic swellable polymer. Formulated microspheres were evaluated for their physical properties such as particle size and surface morphology by optical microscopy and SEM. Entrapment efficiency, floating behavior and drug release study as well the formulation was evaluated for in vivo gastroretention in rabbits using gamma scintigraphy. Formulation showed 75% drug release up to 10 hr with entrapment efficiency of 91% and 88% buoyancy till 10 hr. Gamma scintigraphic studies revealed that the optimized system was retained in the gastric region (stomach) for a prolonged period i.e. more than 5 hr. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Dipyridamole%20microspheres" title="Dipyridamole microspheres">Dipyridamole microspheres</a>, <a href="https://publications.waset.org/abstracts/search?q=gastroretention" title=" gastroretention"> gastroretention</a>, <a href="https://publications.waset.org/abstracts/search?q=HPMC" title=" HPMC"> HPMC</a>, <a href="https://publications.waset.org/abstracts/search?q=optimization%20method" title=" optimization method"> optimization method</a> </p> <a href="https://publications.waset.org/abstracts/8657/development-optimization-and-characterization-of-gastroretentive-multiparticulate-drug-delivery-system" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/8657.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">385</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Optimization of Gastro-Retentive Matrix Formulation and Its Gamma Scintigraphic Evaluation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Swapnila%20V.%20Shinde">Swapnila V. Shinde</a>, <a href="https://publications.waset.org/abstracts/search?q=Hemant%20P.%20Joshi"> Hemant P. Joshi</a>, <a href="https://publications.waset.org/abstracts/search?q=Sumit%20R.%20Dhas"> Sumit R. Dhas</a>, <a href="https://publications.waset.org/abstracts/search?q=Dhananjaysingh%20B.%20Rajput"> Dhananjaysingh B. Rajput</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The objective of the present study is to develop hydro-dynamically balanced system for atenolol, 尾-blocker as a single unit floating tablet. Atenolol shows pH dependent solubility resulting into a bioavailability of 36%. Thus, site specific oral controlled release floating drug delivery system was developed. Formulation includes novice use of rate controlling polymer such as locust bean gum (LBG) in combination of HPMC K4M and gas generating agent sodium bicarbonate. Tablet was prepared by direct compression method and evaluated for physico-mechanical properties. The statistical method was utilized to optimize the effect of independent variables, namely amount of HPMC K4M, LBG and three dependent responses such as cumulative drug release, floating lag time, floating time. Graphical and mathematical analysis of the results allowed the identification and quantification of the formulation variables influencing the selected responses. To study the gastrointestinal transit of the optimized gastro-retentive formulation, in vivo gamma scintigraphy was carried out in six healthy rabbits, after radio labeling the formulation with 99mTc. The transit profiles demonstrated that the dosage form was retained in the stomach for more than 5 hrs. The study signifies the potential of the developed system for stomach targeted delivery of atenolol with improved bioavailability. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=floating%20tablet" title="floating tablet">floating tablet</a>, <a href="https://publications.waset.org/abstracts/search?q=factorial%20design" title=" factorial design"> factorial design</a>, <a href="https://publications.waset.org/abstracts/search?q=gamma%20scintigraphy" title=" gamma scintigraphy"> gamma scintigraphy</a>, <a href="https://publications.waset.org/abstracts/search?q=antihypertensive%20model%20drug" title=" antihypertensive model drug"> antihypertensive model drug</a>, <a href="https://publications.waset.org/abstracts/search?q=HPMC" title=" HPMC"> HPMC</a>, <a href="https://publications.waset.org/abstracts/search?q=locust%20bean%20gum" title=" locust bean gum"> locust bean gum</a> </p> <a href="https://publications.waset.org/abstracts/8593/optimization-of-gastro-retentive-matrix-formulation-and-its-gamma-scintigraphic-evaluation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/8593.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">275</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational anniversary</a></li> </ul> </div> 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Search results for: Swapnila V. Vanshiv