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/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F20805afe527369d997c10f03a2d5ac2e3a49f2a3-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=75 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F20805afe527369d997c10f03a2d5ac2e3a49f2a3-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=75 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F20805afe527369d997c10f03a2d5ac2e3a49f2a3-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=75 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F20805afe527369d997c10f03a2d5ac2e3a49f2a3-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=75 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F20805afe527369d997c10f03a2d5ac2e3a49f2a3-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F20805afe527369d997c10f03a2d5ac2e3a49f2a3-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="object-contain" loading="lazy"/></noscript></span></a></div><div class="border-t-gray-100 border-t-2 flex-auto py-2 "><span class="text-sm text-gray-500 py-2">November 27th 2024</span><div class="py-3"><a class="lg:text-[20px] text-[19px] font-[500]" href="/view/durvalumab-underutilization-highlights-gaps-in-nsclc-treatment-strategies">Durvalumab Underutilization Highlights Gaps in NSCLC Treatment Strategies</a></div><div class="pb-2"><div><span class="text-md "><span class="mr-1 italic">By </span><a class="mr-1 text-sky-800 hover:text-primary" href="/authors/maggie-l-shaw"><i>Maggie L. Shaw</i></a></span></div></div><a href="/view/durvalumab-underutilization-highlights-gaps-in-nsclc-treatment-strategies"><a href="/view/durvalumab-underutilization-highlights-gaps-in-nsclc-treatment-strategies"><p class="mt-1 text-gray-800 text-[13px] line-clamp-6 text-hidden">Accompanying these findings is a call for refined treatment strategies that have potential to better outcomes among patients who have unresectable stage III non–small cell lung cancer (NSCLC).</p></a></a></div></div><div class="flex-wrap w-[60%] flex "><a class="flex w-[50%] flex-col sm:pl-[35px] pl-[20px] pb-[35px] " href="/view/research-priorities-evolve-with-amivantamab-s-broader-nsclc-indications"><div class="w-full lg:h-[134px] h-[100px] relative bg-default-logo-background "><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:absolute;top:0;left:0;bottom:0;right:0"><img alt="" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="fill" class="lg:object-cover object-contain " style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fb924e135f2e0564215c00b9b28af5867586299e6-1200x675.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=75 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fb924e135f2e0564215c00b9b28af5867586299e6-1200x675.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=75 750w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fb924e135f2e0564215c00b9b28af5867586299e6-1200x675.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=75 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fb924e135f2e0564215c00b9b28af5867586299e6-1200x675.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=75 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fb924e135f2e0564215c00b9b28af5867586299e6-1200x675.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=75 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fb924e135f2e0564215c00b9b28af5867586299e6-1200x675.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=75 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fb924e135f2e0564215c00b9b28af5867586299e6-1200x675.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=75 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fb924e135f2e0564215c00b9b28af5867586299e6-1200x675.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fb924e135f2e0564215c00b9b28af5867586299e6-1200x675.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="lg:object-cover object-contain " loading="lazy"/></noscript></span></div><div class="border-t-gray-100 border-t-2 pt-2 pb-2 flex-auto "><a href="/view/research-priorities-evolve-with-amivantamab-s-broader-nsclc-indications"><span class="text-sm text-gray-500">November 21st 2024</span></a><div><a class="text-[14px]" href="/view/research-priorities-evolve-with-amivantamab-s-broader-nsclc-indications"><p class="line-clamp-4 text-hidden font-[500]">Research Priorities Evolve With Amivantamab's Broader NSCLC Indications</p></a></div><div class="py-2"><div><span class="text-md "><span class="mr-1 italic">By </span><a class="mr-1 text-sky-800 hover:text-primary" href="/authors/maggie-l-shaw"><i>Maggie L. 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id="div-gpt-ad-infeed-1"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/improving-early-stage-lung-cancer-care"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/2f3a1ac9660e759d52e0931a9d98039dbfaaf11b-1200x738.jpg?fit=crop&auto=format" alt="Biomarker Scrabble tiles | Image Credit: © lexiconimages-stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 30th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/improving-early-stage-lung-cancer-care">Improving Early-Stage Lung Cancer Care</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/improving-early-stage-lung-cancer-care"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">More than 80% of patients with lung cancer receive care in their communities, but this can leave them vulnerable to gaps in care quality and delivery.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/targeting-progression-amivantamab-s-role-in-nsclc-after-osimertinib"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/b924e135f2e0564215c00b9b28af5867586299e6-1200x675.jpg?fit=crop&auto=format" alt="Martin Dietrich, MD, PhD" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 24th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/targeting-progression-amivantamab-s-role-in-nsclc-after-osimertinib">Targeting Progression: Amivantamab’s Role in NSCLC After Osimertinib</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/targeting-progression-amivantamab-s-role-in-nsclc-after-osimertinib"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Amivantamab's role in non–small cell lung cancer (NSCLC) has been a highlight of the lung cancer space this year, with the 2 most recent approvals based on data from the MARIPOSA and MARIPOSA-2 trials.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/expanding-access-to-nsclc-innovations-challenges-and-opportunities"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/c39dc19c1bfe6d5281fc90047b50c07ec6693e1b-1200x675.jpg?fit=crop&auto=format" alt="Umit Tapan, MD, Boston Medical Center" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 18th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/expanding-access-to-nsclc-innovations-challenges-and-opportunities">Expanding Access to NSCLC Innovations: Challenges and Opportunities</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/expanding-access-to-nsclc-innovations-challenges-and-opportunities"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The current research focus for Umit Tapan, MD, Boston Medical Center, is reducing disparities in lung cancer care and improving treatment access, in particular for immunotherapy and targeted treatments.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-revolutionary-optune-lua-device-in-nsclc"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/140642b191f4ee4e4895ffeda9ce6e76c770dfe2-1200x700.jpg?fit=crop&auto=format" alt="FDA approved | Image Credit: © wladimir1804 -stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 16th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-revolutionary-optune-lua-device-in-nsclc">FDA Approves Optune Lua Device in NSCLC</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-revolutionary-optune-lua-device-in-nsclc"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Optune Lua creates tumor-treating fields to disrupt cancer cell division, and it is used in conjunction with PD-1/PD-L1 inhibitors or docetaxel to treat metastatic non–small cell lung cancer (NSCLC) that has not responded to platinum-based treatment.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/in-cancer-care-innovation-comes-at-a-cost"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/ef6670540061bf438de6dd01c717276a29a46b88-800x519.jpg?fit=crop&auto=format" alt="Emory Winship Cancer Institute | Image: Emory" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 14th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/in-cancer-care-innovation-comes-at-a-cost">In Cancer Care, Innovation Comes at a Cost</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/rose-mcnulty">Rose McNulty</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/in-cancer-care-innovation-comes-at-a-cost"></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/early-biomarker-testing-key-for-perioperative-nsclc-success"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/ab957cdedce11da3322b22dbfce3bc10d9bb0db7-1200x677.png?fit=crop&auto=format" alt="Ticiana Leal, MD, Emory Winship Cancer Institute" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 12th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/early-biomarker-testing-key-for-perioperative-nsclc-success">Early Biomarker Testing Key for Perioperative NSCLC Success</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/rose-mcnulty">Rose McNulty</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/early-biomarker-testing-key-for-perioperative-nsclc-success"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Ticiana Leal, MD, Winship Cancer Institutes, explains the importance of biomarker testing and multidisciplinary conversations while caring for patients with early-stage non–small cell lung cancer (NSCLC).</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-7"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/breathomics-a-low-cost-solution-for-early-lung-cancer-diagnosis-"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/7ab486f90fb406caccbe9bee41702bb1629b2a29-6000x4000.jpg?fit=crop&auto=format" alt="LC and breathing | Image Credit: © Cozine-stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 10th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/breathomics-a-low-cost-solution-for-early-lung-cancer-diagnosis-">Breathomics: A Low-Cost Solution for Early Lung Cancer Diagnosis?</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kimberly-rath-pharmd">Kimberly Rath, PharmD</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/breathomics-a-low-cost-solution-for-early-lung-cancer-diagnosis-"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Study results show that a portable breath analysis device designed for early detection of non–small cell lung cancer may distinguish between patients with the disease and healthy individuals.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/nivolumab-for-approved-as-neoadjuvant-adjuvant-therapy-for-nsclc-by-fda"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/ed6c27d113748c2604bd088076b19fd581b3edd9-4363x3438.jpg?fit=crop&auto=format" alt="FDA Approval | Image Credit: © BHM-stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 4th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/nivolumab-for-approved-as-neoadjuvant-adjuvant-therapy-for-nsclc-by-fda">Nivolumab Approved as Neoadjuvant, Adjuvant Therapy for NSCLC by FDA</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/nivolumab-for-approved-as-neoadjuvant-adjuvant-therapy-for-nsclc-by-fda"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The approval came days before the FDA’s expected deadline and makes this the only PD-1 inhibitor approved for resectable non–small cell lung cancer (NSCLC) in the neoadjuvant and adjuvant settings.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/amivantamab-presents-an-exciting-treatment-opportunity-in-nsclc"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/398f81181f2692ac562b24bc01c26f9ba8dd0284-1200x675.jpg?fit=crop&auto=format" alt="Joshua K. Sabari, MD, NYU Langone" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 30th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/amivantamab-presents-an-exciting-treatment-opportunity-in-nsclc">Amivantamab Presents an Exciting Treatment Opportunity in NSCLC</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/amivantamab-presents-an-exciting-treatment-opportunity-in-nsclc"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">In less than a month, from August 20 to September 19, amivantamab (Ami; Rybrevant, Johnson & Johnson) received 2 approvals from the FDA for use in non–small cell lung cancer (NSCLC). </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/amivantamab-accolades-add-up-for-nsclc"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/b924e135f2e0564215c00b9b28af5867586299e6-1200x675.jpg?fit=crop&auto=format" alt="Martin Dietrich, MD, PhD, Cancer Care Centers of Brevard " width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 27th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/amivantamab-accolades-add-up-for-nsclc">Amivantamab Accolades Add Up for NSCLC </a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/amivantamab-accolades-add-up-for-nsclc"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">On September 19, the FDA handed down its third amivantamab (Rybrevant; Johnson & Johnson) approval for 2024 in non–small cell lung cancer (NSCLC), giving the third-generation tyrosine kinase inhibitor its fourth approval overall. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-osimertinib-in-stage-iii-nsclc"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/50b02c8208491a0157e5062fd1eb29217075630e-1200x738.jpg?fit=crop&auto=format" alt="FDA | Image Credit: © wladimir1804-stockk.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-osimertinib-in-stage-iii-nsclc">FDA Approves Osimertinib in Stage III NSCLC</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-osimertinib-in-stage-iii-nsclc"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The approval means an additional indication for osimertinib (Tagrisso; AstraZeneca) for adult patients who have unresectable stage III non–small cell lung cancer (NSCLC) with EGFR mutation.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-amivantamab-for-egfr-positive-nsclc-with-exon-19-deletion-exon-21-l858r-substitution"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/230cc68de8006da0c7065c3c5622f2c9295de872-5824x3264.jpg?fit=crop&auto=format" alt="AI generated lungs and doctor | Image credit: PRASANNAPIX - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 20th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-amivantamab-for-egfr-positive-nsclc-with-exon-19-deletion-exon-21-l858r-substitution">FDA Approves Amivantamab for EGFR-Positive NSCLC With Exon 19 Deletion, Exon 21 L858R Substitution</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/skylar-jeremias">Skylar Jeremias</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-amivantamab-for-egfr-positive-nsclc-with-exon-19-deletion-exon-21-l858r-substitution"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The FDA approval of amivantamab-vmjw (Rybrevant) in combination with chemotherapy is the first targeted treatment to cut disease progression risk for EGFR-positive non–small cell lung cancer (NSCLC).</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-13"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/liquid-biopsy-advances-vital-role-in-biomarker-testing-in-lung-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/f41f4f274375893c9675c5fd07a821aec240b442-1200x738.jpg?fit=crop&auto=format" alt="David P. Carbone, MD, PhD, The Ohio State University" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 16th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/liquid-biopsy-advances-vital-role-in-biomarker-testing-in-lung-cancer">Liquid Biopsy Advances: Vital Role in Biomarker Testing in Lung Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/liquid-biopsy-advances-vital-role-in-biomarker-testing-in-lung-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Here we conclude our discussion with David P. Carbone, MD, PhD, The Ohio State University, by addressing the importance of both advocacy for and education on biomarker testing in the lung cancer space. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/thio-combo-yields-survival-benefit-in-advanced-nsclc"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/1fc6174ed4d45e077d7aa264d6a140119574d47d-1200x738.jpg?fit=crop&auto=format" alt="Sparkling telomere | Image Credit: Dr_Microbe - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 13th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/thio-combo-yields-survival-benefit-in-advanced-nsclc">THIO Combo Yields Survival Benefit in Advanced NSCLC</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/russ-conroy">Russ Conroy</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/thio-combo-yields-survival-benefit-in-advanced-nsclc"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Developers anticipate releasing full efficacy results from the phase 2 THIO-101 trial later this year.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/novel-mechanisms-set-fda-approved-amivantamab-lazertinib-combo-apart-in-nsclc"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/398f81181f2692ac562b24bc01c26f9ba8dd0284-1200x675.jpg?fit=crop&auto=format" alt="Joshua K. Sabari, MD, NYU Langone" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 30th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/novel-mechanisms-set-fda-approved-amivantamab-lazertinib-combo-apart-in-nsclc">Novel Mechanisms Set FDA-Approved Amivantamab-Lazertinib Combo Apart in NSCLC</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/novel-mechanisms-set-fda-approved-amivantamab-lazertinib-combo-apart-in-nsclc"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">This newest approval for amivantamab is the second approval in 6 months for the EGFR and MET bispecific antibody.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/measuring-the-magnitude-of-systemic-inflammatory-response-in-nsclc"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/46ed1f28dea92f2cb13e14b5856c7258caea556e-5000x3750.jpg?fit=crop&auto=format" alt="Lung cancer | Image credit: Sebastian Kaulitzki - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 27th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/measuring-the-magnitude-of-systemic-inflammatory-response-in-nsclc">Measuring the Magnitude of Systemic Inflammatory Response in NSCLC</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/julia-bonavitacola">Julia Bonavitacola</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/measuring-the-magnitude-of-systemic-inflammatory-response-in-nsclc"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Measures of systemic inflammation used for the liver, including C-reactive protein-albumin ratio and modified Glasgow prognostic score, demonstrated prognostic value in non–small cell lung cancer (NSCLC).</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/beyond-early-stage-biomarker-testing-s-role-in-advanced-lung-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/f41f4f274375893c9675c5fd07a821aec240b442-1200x738.jpg?fit=crop&auto=format" alt="David P. Carbone, MD, PhD, The Ohio State University" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 23rd 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/beyond-early-stage-biomarker-testing-s-role-in-advanced-lung-cancer">Beyond Early Stage: Biomarker Testing's Role in Advanced Lung Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/beyond-early-stage-biomarker-testing-s-role-in-advanced-lung-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">In part 1 of our interview with David P. Carbone, MD, PhD, The Ohio State University, he addressed why it is important to conduct biomarker testing in both lung cancer overall and non–small cell lung cancer more specifically. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/lazertinib-with-amivantamab-approved-by-fda-for-use-in-nsclc"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/407d27c5fd74836a18293620e5dbacab64d631cd-2000x2000.jpg?fit=crop&auto=format" alt="FDA Approved" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 20th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/lazertinib-with-amivantamab-approved-by-fda-for-use-in-nsclc">Lazertinib With Amivantamab Approved by FDA for Use in NSCLC</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/julia-bonavitacola">Julia Bonavitacola</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/lazertinib-with-amivantamab-approved-by-fda-for-use-in-nsclc"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Patients with non-small cell lung cancer (NSCLC) can use lazertinib in combination with amivantamab as a first-line treatment.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-19"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/icis-extend-survival-in-older-patients-with-nsclc-brian-metastases"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/08a603863e884995f4c446e50c05ccf798dea5d7-1200x738.jpg?fit=crop&auto=format" alt="brain and lungs | Image Credit: magicmine-stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 15th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/icis-extend-survival-in-older-patients-with-nsclc-brian-metastases">ICIs Extend Survival in Older Patients With NSCLC, Brain Metastases</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/icis-extend-survival-in-older-patients-with-nsclc-brian-metastases"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">This investigation was conducted among older, frail patients, a population typically underrepresented in clinical trials.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/biomarker-testing-key-to-personalized-lung-cancer-care"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/f41f4f274375893c9675c5fd07a821aec240b442-1200x738.jpg?fit=crop&auto=format" alt="Biomarker Testing: Key to Personalized Lung Cancer Care" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 9th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/biomarker-testing-key-to-personalized-lung-cancer-care">Biomarker Testing: Key to Personalized Lung Cancer Care</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/biomarker-testing-key-to-personalized-lung-cancer-care"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">David P. Carbone, MD, PhD, director of the thoracic oncology center at The Ohio State University in Columbus, discusses the importance of biomarker testing in both lung cancer overall and non–small cell lung cancer specifically. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/study-suggests-need-for-new-second-line-nsclc-therapies-to-follow-osimertinib"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/51ba9a76e22bd183e50924e69f023c02cf090895-3840x2160.jpg?fit=crop&auto=format" alt="Lung cancer | Image credit: appledesign - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 5th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/study-suggests-need-for-new-second-line-nsclc-therapies-to-follow-osimertinib">Study Suggests Need for New Second-Line NSCLC Therapies to Follow Osimertinib</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/julia-bonavitacola">Julia Bonavitacola</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/study-suggests-need-for-new-second-line-nsclc-therapies-to-follow-osimertinib"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">New therapies to treat EGFR-mutated non–small cell lung cancer (NSCLC) following EGFR tyrosine kinase inhibitors (TKIs) are needed to address EGFR TKI resistance after osimertinib.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/nsclc-study-highlights-need-for-adjuvant-trials-in-early-stage-disease"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/639ac270b32353f24e9d688c0b567eec75c8a393-1200x738.jpg?fit=crop&auto=format" alt="Lung cancer diagnosis | Image Credit: Vitalii Vodolazskyi-stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 1st 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/nsclc-study-highlights-need-for-adjuvant-trials-in-early-stage-disease">NSCLC Study Highlights Need for Adjuvant Trials in Early-Stage Disease</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/nsclc-study-highlights-need-for-adjuvant-trials-in-early-stage-disease"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Visceral pleural invasion of non–small cell lung cancer (NSCLC) was investigated in this analysis for its potential to predispose patients to worse survival outcomes and greater chances of disease recurrence. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/odac-votes-to-require-trial-assessment-of-neoadjuvant-vs-adjuvant-benefits-in-resectable-nsclc"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/419d9dd6fef44b012d21e5267c74b9db4efe4125-1200x738.jpg?fit=crop&auto=format" alt="FDA | Image Credit: wladimir1804-stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 28th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/odac-votes-to-require-trial-assessment-of-neoadjuvant-vs-adjuvant-benefits-in-resectable-nsclc">ODAC Votes to Require Trial Assessment of Neoadjuvant vs Adjuvant Benefits in Resectable NSCLC</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/caroline-seymour">Caroline Seymour</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/odac-votes-to-require-trial-assessment-of-neoadjuvant-vs-adjuvant-benefits-in-resectable-nsclc"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Should the FDA require that new trial design proposals for perioperative regimens for resectable non–small cell lung cancer (NSCLC) include adequate within trial assessment?</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/atezolizumab-for-nsclc-safe-and-effective-before-and-after-crt"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/a986e2de9c6b11dccdccfc7b028e228b7b23feaf-7000x5430.jpg?fit=crop&auto=format" alt="Lungs | Image credit: yodiyim - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 25th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/atezolizumab-for-nsclc-safe-and-effective-before-and-after-crt">Atezolizumab for NSCLC Safe and Effective Before and After CRT</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/julia-bonavitacola">Julia Bonavitacola</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/atezolizumab-for-nsclc-safe-and-effective-before-and-after-crt"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Patients with unresectable stage III non–small cell lung cancer (NSCLC) who received atezolizumab before and after chemoradiation therapy (CRT) had both safe and effective results.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-25"></div></div></div><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/nsclc-care-could-benefit-from-antibiotic-stewardship"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/acab9ec30c21572e13d167df4a2b574d02056dee-1200x728.jpg?fit=crop&auto=format" alt="Antibiotics and lung cancer | Image Credit: Елена Бутусова-stockk.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 19th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/nsclc-care-could-benefit-from-antibiotic-stewardship">NSCLC Care Could Benefit From Antibiotic Stewardship</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/nsclc-care-could-benefit-from-antibiotic-stewardship"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">For this analysis, investigators were interested in patient non–small cell lung cancer (NSCLC)–related outcomes from antibiotic administration before immunotherapy alone or immunotherapy and chemotherapy.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/evaluating-amivantamab-and-lazertinib-key-findings-from-the-chrysalis-2-study-at-asco-2024"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/b98bfde3d2eb3374c5092189f10385d06a3540ae-1920x1080.png?fit=crop&auto=format" alt="Jason Porter, MD, an expert on lung cancer" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 17th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/evaluating-amivantamab-and-lazertinib-key-findings-from-the-chrysalis-2-study-at-asco-2024">Evaluating Amivantamab and Lazertinib: Key Findings from the CHRYSALIS-2 Study at ASCO 2024</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/jason-porter-md">Jason Porter, MD</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/evaluating-amivantamab-and-lazertinib-key-findings-from-the-chrysalis-2-study-at-asco-2024"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A key opinion leader examines the combination therapy of amivantamab and lazertinib in the CHRYSALIS-2 study for treatment-naïve patients or those with 2 or more prior lines of therapy, and its potential implications for non-small cell lung cancer treatment.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/asco-2024-key-findings-of-the-laura-trial-on7-19-osimertinib-for-egfr-mutated-nsclc"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/b98bfde3d2eb3374c5092189f10385d06a3540ae-1920x1080.png?fit=crop&auto=format" alt="Jason Porter, MD, an expert on lung cancer" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 17th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/asco-2024-key-findings-of-the-laura-trial-on7-19-osimertinib-for-egfr-mutated-nsclc">ASCO 2024: Key Findings of the LAURA Trial on7:19 Osimertinib for EGFR-Mutated NSCLC</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/jason-porter-md">Jason Porter, MD</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/asco-2024-key-findings-of-the-laura-trial-on7-19-osimertinib-for-egfr-mutated-nsclc"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Jason Porter, MD, analyzes critical insights from the 2024 ASCO Annual Meeting presentation on progression-free survival data from the LAURA phase 3 trial, which evaluated osimertinib in patients with unresectable stage III EGFR-mutated non-small cell lung cancer who did not progress after definitive chemoradiotherapy.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/lung-cancer-detection-trends-show-shift-in-pandemic-aftermath"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/6078ceb5af94b9b34dd15a6dd39a30cafadb4eb9-1200x675.jpg?fit=crop&auto=format" alt="Jessica K. Paulus, ScD, Ontada" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 13th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/lung-cancer-detection-trends-show-shift-in-pandemic-aftermath">Lung Cancer Detection Trends Show Shift in Pandemic Aftermath</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/lung-cancer-detection-trends-show-shift-in-pandemic-aftermath"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">In this final segment of our interview with Ontada's Jessica K. Paulus, ScD, she explains how her team's data presented at the American Society of Clinical Oncology annual conference may translate to the real world.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/patient-satisfaction-with-letter-based-communication-of-lcs-pulmonary-nodule-results"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/5421358c8f117ee86126333e135f08cf1e61ded6-778x382.png?fit=crop&auto=format" alt="AJMC" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 10th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/patient-satisfaction-with-letter-based-communication-of-lcs-pulmonary-nodule-results">Patient Satisfaction With Letter-Based Communication of LCS Pulmonary Nodule Results</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/daoyue-wang-md">Daoyue Wang, MD</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/rui-shi-md">Rui Shi, MD</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/lili-hu-md">Lili Hu, MD</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/ran-chen-md">Ran Chen, MD</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/jun-sun-bs">Jun Sun, BS</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/wei-huang-bs">Wei Huang, BS</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/hongyang-zhou-bs">Hongyang Zhou, BS</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/feng-rong-md">Feng Rong, MD</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/patient-satisfaction-with-letter-based-communication-of-lcs-pulmonary-nodule-results"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Patients were satisfied with receiving their lung cancer screening (LCS) pulmonary nodule results via letter and considered the amount of information provided in the letter appropriate.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/age-pneumonectomy-linked-to-poor-nsclc-surgery-outcomes"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/7556228d35b22cacc03c5c8b2f9be8d63292020f-1200x728.jpg?fit=crop&auto=format" alt="lung surgery | Image Credit: Tom-stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 9th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/age-pneumonectomy-linked-to-poor-nsclc-surgery-outcomes">Age, Pneumonectomy Linked to Poor NSCLC Surgery Outcomes</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/age-pneumonectomy-linked-to-poor-nsclc-surgery-outcomes"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">This new analysis incorporated 1997-2013 data on patients with a history of surgical resection of stage IIIA-N2 non-small cell lung cancer (NSCLC) and their postop complications to evaluate the possibility of better identifying future surgical candidates.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div></div><div class="w-full text-center flex justify-center pb-24"><a class="px-4 py-2 border-y border-r bg-primary text-white" href="/compendium/nsclc?page=1">1</a><a class="px-4 py-2 border-y border-r " href="/compendium/nsclc?page=2">2</a><a class="px-4 py-2 border-y border-r " href="/compendium/nsclc?page=3">3</a><a class="px-4 py-2 border-y border-r " href="/compendium/nsclc?page=4">4</a><a 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And again, I think it's critical to work together as a multidisciplinary team so that we can continue to address the real-world questions, but also the questions that are still important from a clinical trial standpoint.","_key":"e91be065d4e50"}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"3b1304ed7fff","markDefs":[],"children":[{"marks":[],"text":"","_key":"cdfa6efbea590","_type":"span"}]},{"markDefs":[{"blank":true,"_type":"link","href":"https://www.ajmc.com/view/dr-ticiana-leal-on-recent-advancements-in-perioperative-nsclc-care","_key":"84066d510868"}],"children":[{"_type":"span","marks":[],"text":"Now, from a clinical trial standpoint, I think key questions that remain are going to be duration of therapy and also whether there is a significant advantage of perioperative vs a neoadjuvant approach with chemoimmunotherapy given the results that we're seeing ","_key":"873bc62136180"},{"_type":"span","marks":["84066d510868"],"text":"across these trials","_key":"873bc62136181"},{"_type":"span","marks":[],"text":", because that also has to do with cost. And I think when you think about a perioperative approach with a full year of immunotherapy in the postoperative setting, that may be a challenge globally as we deliver this therapy to patients, and is there a real gain depending on the results of that postoperative surgical specimen in terms of pathologic response, and so on.","_key":"873bc62136182"}],"_type":"block","style":"normal","_key":"9d2d462c4e9a"},{"_key":"ad56ec8dfd86","markDefs":[],"children":[{"_key":"a12fa67c960a0","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_key":"58e0fb6a6acd0","_type":"span","marks":[],"text":"Another key question that I think will be really important for us to understand more about is the role of ctDNA [circulating tumor DNA] and how that can also help us risk-stratify patients and understand duration of therapy. And then certainly, I think it's really key to continue to build upon that backbone of chemoimmunotherapy. Are there additional novel agents that we can use in the adjuvant setting in the perioperative approach for patients who don't achieve a pathCR [pathological complete response]? So some critical questions, a lot of interesting clinical trials and designs that I think will be required to answer those questions."}],"_type":"block","style":"normal","_key":"a319b94f2f73"},{"children":[{"_type":"span","marks":[],"text":"","_key":"89d5c97e15350"}],"_type":"block","style":"normal","_key":"fd74ffeb881e","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"From the real-world setting, I think it's from the institutions and guidelines, not only in the US but globally, really coming together for consensus in terms of establishing the role of multidisciplinary care for patients. Who are the ideal candidates for multidisciplinary care? 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Sabari, MD, oncologist with NYU Langone Perlmutter Cancer Center, about ","_key":"8f9a8332826e2"},{"_key":"8f9a8332826e3","_type":"span","marks":["2429c87c75d2"],"text":"the August approval"},{"_type":"span","marks":[],"text":", he discusses the toxicities that accompany its intravenous administration, in particular, the skin-related reactions and the risk of venous thromboembolism.","_key":"8f9a8332826e4"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_key":"8f961f1fc3990","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"1e56d5657414"},{"style":"normal","_key":"ed321d6d4f03","markDefs":[],"children":[{"_type":"span","marks":["em"],"text":"This transcript has been lightly edited for clarity.","_key":"088435962a4c0"}],"_type":"block"},{"children":[{"_key":"045f27b9954a0","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"ac82066f6648","markDefs":[]},{"children":[{"_type":"span","marks":["strong","underline"],"text":"Transcript","_key":"ac1083f506830"}],"_type":"block","style":"normal","_key":"0955045585bf","markDefs":[]},{"_key":"b30dea2bc4c9","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"14e426a5d51e0"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"Can you discuss what are notable adverse effects of amivantamab treatment and how to best manage them?","_key":"d8cc32bf27590"}],"_type":"block","style":"normal","_key":"339ad3d4414b"},{"children":[{"_type":"span","marks":[],"text":"","_key":"6a8ade7db5d20"}],"_type":"block","style":"normal","_key":"9a53b7eec2cf","markDefs":[]},{"_type":"block","style":"normal","_key":"36317d0eaa4c","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The side effects for amivantamab intravenous most commonly are infusion-related reactions, and these side effects occur on cycle 1, day 1. We know how to manage them. We've had a lot of experience in ","_key":"7d6ccbc0d3de0"},{"_type":"span","marks":["em"],"text":"EGFR","_key":"7d6ccbc0d3de1"},{"_type":"span","marks":[],"text":" exon 20 insertion–mutant disease. Interestingly, in the subcutaneous formulation, which is not yet FDA approved, we sort of mitigated; we don't see this infusion-related reaction. So with the IV [intravenous] formulation of amivantamab, it’s important to split the dose into cycle 1, day 1 and day 2, and to premedicate patients with steroids, antipyretics, as well as other types of medicines in the label.","_key":"7d6ccbc0d3de2"}]},{"_key":"18461dbe9f5c","markDefs":[],"children":[{"marks":[],"text":"","_key":"cfcab872005b0","_type":"span"}],"_type":"block","style":"normal"},{"_key":"6ea33cab6f77","markDefs":[{"nofollow":true,"blank":true,"_type":"link","href":"https://clinicaltrials.gov/study/NCT06120140","_key":"229136dcaa9c"}],"children":[{"_type":"span","marks":[],"text":"The other side effects that I think are a bit more troublesome for amivantamab are the skin toxicities, things such as dermatitis paronychia. These are EGFR-mediated skin toxicities, so a lot of work has gone in now to better understand and manage and mitigate the skin toxicities. An ongoing trial, the COCOON study [","_key":"e02a03be56680"},{"_type":"span","marks":["229136dcaa9c"],"text":"NCT06120140","_key":"e02a03be56681"},{"marks":[],"text":"], is looking at prophylactic management of skin toxicities with use of antibiotics such as doxycycline prophylactically and other ceramide-based topical creams.","_key":"e02a03be56682","_type":"span"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"text":"","_key":"7b0b5c92d9360","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"3eb3b5b8e180"},{"children":[{"text":"Another side effect of amivantamab that one should be monitoring closely is the increased risk of venous thromboembolism. We know that there was a 3-fold rate of venous thromboembolism when Ami was given in combination with lazertinib [Ami-Laz], and I think to mitigate that we are now giving prophylactic anticoagulation to all patients starting on this regimen—at least for the first 4 months, as per the label—and this has reduced the rate of venous thromboembolism significantly. So again, I think despite the toxicities with this therapy, I think if managed appropriately, we are able to achieve more durable responses as well as longer progression-free survival in our patients.","_key":"b212499b41450","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"7aeff8d12f99","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"9b03a3de01f40"}],"_type":"block","style":"normal","_key":"7f5f6cddd226"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"So when we compare the toxicity profile of Ami-Laz vs osimertinib, there clearly is higher toxicity profile with amivantamab and lazertinib. The only one that really stands out as being different is diarrhea. Diarrhea, you see a higher rate of grade 1/2 toxicity for osimertinib than you do for amivantamab and lazertinib. 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This study investigated 5-year outcomes associated with cemiplimab—a PD-L1 inhibitor—monotherapy in patients with non–small cell lung cancer (NSCLC) with lower expression of PD-L1.","_key":"8195f2ef48982"}],"_type":"block","style":"normal","_key":"bd2be050e356"},{"style":"normal","_key":"e5e43d16122f","markDefs":[],"children":[{"text":"","_key":"09f6c7ec50150","_type":"span","marks":[]}],"_type":"block"},{"_key":"e0f757f9924a","markDefs":[],"children":[{"_type":"span","marks":[],"text":"In this interview with ","_key":"deb0589c12180"},{"_type":"span","marks":["em"],"text":"The American Journal of Managed Care","_key":"deb0589c12181"},{"marks":["superscript"],"text":"®","_key":"526a7d70fd8b","_type":"span"},{"_key":"751ff8905957","_type":"span","marks":[],"text":", Baramidze elaborates on the study’s key findings and outlines the patient characteristics most important for a clinician to consider ahead of initiating treatment with cemiplimab."}],"_type":"block","style":"normal"},{"children":[{"_type":"span","marks":[],"text":"","_key":"68a1ab2f50970"}],"_type":"block","style":"normal","_key":"d7ba1812e682","markDefs":[]},{"_type":"block","style":"normal","_key":"6aec3d151764","markDefs":[],"children":[{"_type":"span","marks":["em"],"text":"This transcript has been lightly edited for clarity.","_key":"47eb61206ad10"}]},{"_type":"block","style":"normal","_key":"7ff32ad4933e","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"e48e07d15c6c0"}]},{"_key":"eeab0439cb19","markDefs":[],"children":[{"text":"Transcript","_key":"673a62cbf1c60","_type":"span","marks":["strong","underline"]}],"_type":"block","style":"normal"},{"children":[{"_key":"e827646384630","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"d0b5b1c59c7b","markDefs":[]},{"children":[{"_type":"span","marks":["strong"],"text":"What do the 5-year outcomes of the EMPOWER-Lung 1 trial reveal about the long-term efficacy and safety of cemiplimab monotherapy? Are there any new insights or unexpected findings from this extended follow-up?","_key":"10b152fe43770"}],"_type":"block","style":"normal","_key":"dc2235cd0dda","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"6f7d6288a0c2"}],"_type":"block","style":"normal","_key":"54f078be667b"},{"style":"normal","_key":"c13939ed4a66","markDefs":[],"children":[{"_type":"span","marks":[],"text":"EMPOWER-Lung 1 is a trial that investigated the efficacy and the safety of the cemiplimab PD-L1 inhibitor in patients with advanced non–small cell lung cancer. Five-year outcomes provide valuable insight into the long-term effects of the treatment, and the 5-year follow-up data generally showed that cemiplimab monotherapy continues to provide significant long-term survival benefits. In terms of safety profile, cemiplimab still remains consistent with earlier reporting and the new treatment related-adverse events are generally manageable. The key findings were: We have seen the durability of response, and the patients who initially responded well to cemiplimab often continued to benefit from the treatment.","_key":"ec655882cce90"}],"_type":"block"},{"_type":"block","style":"normal","_key":"ad11cf465181","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"6256856179f6"}]},{"style":"normal","_key":"092a621db94a","markDefs":[],"children":[{"_type":"span","marks":[],"text":"In summary, I can say that the 5-year outcomes from the EMPOWER-Lung 1 trial reinforce the long-term efficacy of cemiplimab monotherapy, and it highlighted its potential for durable responses and manageable long-term safety. So, this finding further supports the availability of this treatment for non-small cell lung cancer, advanced or metastatic.","_key":"8a1bed32a4df"}],"_type":"block"},{"_key":"88b06672e434","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"a644ee4483650"}],"_type":"block","style":"normal"},{"children":[{"marks":["strong"],"text":"How should clinicians approach patient selection for cemiplimab monotherapy in advanced NSCLC? Are there additional biomarkers or patient characteristics that could further refine eligibility or predict response?","_key":"9328b8998eb00","_type":"span"}],"_type":"block","style":"normal","_key":"de18dd783b46","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"90de8213b6a30"}],"_type":"block","style":"normal","_key":"8d49e429b651"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Based on the outcomes of EMPOWER-Lung 1, clinicians should consider several key factors when selecting the patient for the cemiplimab monotherapy in advanced non–small cell lung cancer. But the key biomarker is PD-L1 expression for predicting the response. 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"}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"bac322aa3926"}],"_type":"block","style":"normal","_key":"8625a89e2d90"},{"_type":"block","style":"normal","_key":"a9e89522e614","markDefs":[],"children":[{"_type":"span","marks":["strong","underline"],"text":"Transcript","_key":"30feb42f007d"}]},{"_type":"block","style":"normal","_key":"a5597e52eee2","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"What are the most recent advancements in perioperative therapy for NSCLC?","_key":"937fa159fe510"}]},{"markDefs":[],"children":[{"text":"There have been significant advances in the perioperative setting for patients with early-stage non–small cell lung cancer. ","_key":"9f97085a1f4e0","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"71f49ddba308"},{"_type":"block","style":"normal","_key":"4a976d414d83","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"e7cbbec48977"}]},{"_key":"1ae8af9057b5","markDefs":[],"children":[{"text":"We've seen several approvals of therapies in the perioperative space with chemoimmunotherapy, with the approval of KEYNOTE-671 [NCT03425643; pembrolizumab with chemotherapy], and then most recently, we've seen the approval approval of the AEGEAN [NCT03800134; durvalumab with chemotherapy] regimen. In addition, we also previously saw the approval of neoadjuvant chemoimmunotherapy with CheckMate 816 [NCT0299852; nivolumab with chemotherapy]. And then we also have adjuvant strategies with approvals of IMpower-010 [NCT02486718; atezolizumab], and then KEYNOTE-091 [NCT02504372; pembrolizumab].\n","_key":"5db51c138300","_type":"span","marks":[]}],"_type":"block","style":"normal"},{"children":[{"_type":"span","marks":[],"text":"In addition, we also have approvals of targeted therapy in the adjuvant space, we saw approval of agents with the ADAURA trial [NCT02511106; osimertinib] as well as the ALINA trial [NCT03456076; alectinib].","_key":"386da9db4ca8"}],"_type":"block","style":"normal","_key":"5932b1d14af8","markDefs":[]},{"style":"normal","_key":"cb059ac3171c","markDefs":[],"children":[{"text":"","_key":"865281974767","_type":"span","marks":[]}],"_type":"block"},{"style":"normal","_key":"a917dfb7b5d8","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"How have recent clinical trials influenced the standard of care for perioperative therapy in NSCLC?","_key":"e58088557e2a0"}],"_type":"block"},{"children":[{"_type":"span","marks":[],"text":"These have really changed the way that we treat patients with early-stage non–small cell lung cancer, and certainly that has been a significant gain for patients as we try to optimize treatment strategies for patients with early-stage non–small cell lung cancer, where the goal here really is a cure.","_key":"1ee5067e23060"}],"_type":"block","style":"normal","_key":"53794fe6198e","markDefs":[]},{"markDefs":[],"children":[{"marks":[],"text":"","_key":"2f664c1a95b8","_type":"span"}],"_type":"block","style":"normal","_key":"24bf1c9b4b9c"},{"_type":"block","style":"normal","_key":"af1cbf31235a","markDefs":[],"children":[{"_type":"span","marks":[],"text":"With the perioperative strategies, utilizing chemoimmunotherapy pre-op as well as post-op, we've seen improvement in event-free survival. We've seen improvement in path-CR [pathological complete response], and then in the case of KEYNOTE-671 with perioperative chemoimmunotherapy with pembrolizumab, we've seen improvement in overall survival. In addition, we saw improvement in event-free survival and path-CR with a neoadjuvant approach with CheckMate 816.","_key":"9709b8477344"}]},{"_type":"block","style":"normal","_key":"f1a7d4802f5d","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"ad729b006ea0"}]},{"style":"normal","_key":"63e71b29a473","markDefs":[],"children":[{"marks":[],"text":"Certainly, these have definitely changed the way that we treat. I think it's very important to establish a workflow in a multidisciplinary fashion where patients can have access to all of the different specialists that will be involved in making these really important treatment decisions together with the patients.","_key":"f7c80ea4ae53","_type":"span"}],"_type":"block"},{"style":"normal","_key":"a34c37cec275","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"42ec8589357b0"}],"_type":"block"},{"_key":"9113a2dfc940","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"What is the current role of immunotherapy in the perioperative setting for NSCLC?","_key":"a733c30303130"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"4ec92666defc"}],"_type":"block","style":"normal","_key":"d28e2fe4cbd9"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"I think based on the results of these major trials that we've briefly touched upon, it's really important to highlight that really it's the role of chemoimmunotherapy in a lot of these trials. When we think about the best outcomes that we've seen in these trials, it really is the combination of chemotherapy with immunotherapy, either in the neoadjuvant or in the perioperative setting. ","_key":"fb30c857998c0"}],"_type":"block","style":"normal","_key":"cc6719d4b069"},{"children":[{"_type":"span","marks":[],"text":"","_key":"2a644641680f"}],"_type":"block","style":"normal","_key":"b9446c7c4392","markDefs":[]},{"_key":"4e9b96ef46a7","markDefs":[],"children":[{"_type":"span","marks":[],"text":"I think for patients that don't receive perioperative treatment options, there is still a very important role for immunotherapy in the adjuvant setting, with approvals of atezolizumab, as well as KEYNOTE-091 with pembrolizumab for patients in the adjuvant setting.","_key":"189dfe32cbb3"}],"_type":"block","style":"normal"}],"title":"Dr Ticiana Leal on Recent Advancements in Perioperative NSCLC Care","_createdAt":"2024-09-04T20:48:41Z","is_visible":true,"updatedOn":null,"_id":"09b51da0-c78c-45de-8e52-19711a206ea7","_updatedAt":"2024-09-05T12:58:45Z","authorMapping":[{"lastName":"McNulty","_createdAt":"2020-10-06T12:46:55Z","_type":"author","_id":"9243ec08-02c0-4c8e-b586-619334f7f95d","profileImage":{"_type":"mainImage","alt":"Rose McNulty","asset":{"_ref":"image-8445b436ab605560bc20c7e9c6f4f60912e914df-430x430-png","_type":"reference"}},"_updatedAt":"2024-06-13T13:26:39Z","url":{"current":"rose-mcnulty","_type":"slug"},"firstName":"Rose","displayName":"Rose McNulty","_rev":"N7mKycgLbGtEq6btkTWlrd","biography":[{"_key":"3a2b873558e3","markDefs":[],"children":[{"text":"Rose is an associate editorial director at ","_key":"123612bd9b2b0","_type":"span","marks":[]},{"_type":"span","marks":["em"],"text":"The American Journal of Managed Care","_key":"2cd28f20d2b9"},{"text":"®","_key":"032c8e723210","_type":"span","marks":["superscript"]},{"_type":"span","marks":[],"text":" (","_key":"e2d5625eae03"},{"_type":"span","marks":["em"],"text":"AJMC","_key":"3af109dc927a"},{"_type":"span","marks":["superscript"],"text":"®","_key":"1903cd426eb6"},{"_type":"span","marks":[],"text":").","_key":"688f269c2ad0"}],"_type":"block","style":"normal"},{"markDefs":[{"nofollow":true,"blank":true,"_type":"link","href":"https://www.linkedin.com/in/rose-mcnulty-652a09126/","_key":"a1a427c7e90e"}],"children":[{"_type":"span","marks":[],"text":"She has a BA in journalism \u0026 media studies and Spanish from Rutgers University. 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