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data-event-name="pinnable-header.vector-toc.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-toc.unpin">hide</button> </div> <ul class="vector-toc-contents" id="mw-panel-toc-list"> <li id="toc-mw-content-text" class="vector-toc-list-item vector-toc-level-1"> <a href="#" class="vector-toc-link"> <div class="vector-toc-text">(Top)</div> </a> </li> <li id="toc-Classification" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Classification"> <div class="vector-toc-text"> <span class="vector-toc-numb">1</span> <span>Classification</span> </div> </a> <button aria-controls="toc-Classification-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Classification subsection</span> </button> <ul id="toc-Classification-sublist" class="vector-toc-list"> <li id="toc-Uterine_Adenomyoma" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Uterine_Adenomyoma"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.1</span> <span>Uterine Adenomyoma</span> </div> </a> <ul id="toc-Uterine_Adenomyoma-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Extrauterine_Adenomyoma" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Extrauterine_Adenomyoma"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.2</span> <span>Extrauterine Adenomyoma</span> </div> </a> <ul id="toc-Extrauterine_Adenomyoma-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Gallbladder_Adenomyoma" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Gallbladder_Adenomyoma"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.3</span> <span>Gallbladder Adenomyoma</span> </div> </a> <ul id="toc-Gallbladder_Adenomyoma-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Signs_and_symptoms" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Signs_and_symptoms"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Signs and symptoms</span> </div> </a> <button aria-controls="toc-Signs_and_symptoms-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Signs and symptoms subsection</span> </button> <ul id="toc-Signs_and_symptoms-sublist" class="vector-toc-list"> <li id="toc-Uterine_Adenomyoma_2" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Uterine_Adenomyoma_2"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.1</span> <span>Uterine Adenomyoma</span> </div> </a> <ul id="toc-Uterine_Adenomyoma_2-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Extrauterine_Adenomyoma_2" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Extrauterine_Adenomyoma_2"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.2</span> <span>Extrauterine Adenomyoma</span> </div> </a> <ul id="toc-Extrauterine_Adenomyoma_2-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Gallbladder_Adenomyoma_2" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Gallbladder_Adenomyoma_2"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.3</span> <span>Gallbladder Adenomyoma</span> </div> </a> <ul id="toc-Gallbladder_Adenomyoma_2-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Causes" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Causes"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Causes</span> </div> </a> <button aria-controls="toc-Causes-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Causes subsection</span> </button> <ul id="toc-Causes-sublist" class="vector-toc-list"> <li id="toc-Uterine_Adenomyoma_3" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Uterine_Adenomyoma_3"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.1</span> <span>Uterine Adenomyoma</span> </div> </a> <ul id="toc-Uterine_Adenomyoma_3-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Extrauterine_Adenomyoma_3" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Extrauterine_Adenomyoma_3"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.2</span> <span>Extrauterine Adenomyoma</span> </div> </a> <ul id="toc-Extrauterine_Adenomyoma_3-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Gallbladder_Adenomyoma_3" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Gallbladder_Adenomyoma_3"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.3</span> <span>Gallbladder Adenomyoma</span> </div> </a> <ul id="toc-Gallbladder_Adenomyoma_3-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Diagnosis" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Diagnosis"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Diagnosis</span> </div> </a> <button aria-controls="toc-Diagnosis-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Diagnosis subsection</span> </button> <ul id="toc-Diagnosis-sublist" class="vector-toc-list"> <li id="toc-Uterine_Adenomyoma_4" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Uterine_Adenomyoma_4"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.1</span> <span>Uterine Adenomyoma</span> </div> </a> <ul id="toc-Uterine_Adenomyoma_4-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Extrauterine_Adenomyoma_4" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Extrauterine_Adenomyoma_4"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.2</span> <span>Extrauterine Adenomyoma</span> </div> </a> <ul id="toc-Extrauterine_Adenomyoma_4-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Gallbladder_Adenomyoma_4" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Gallbladder_Adenomyoma_4"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.3</span> <span>Gallbladder Adenomyoma</span> </div> </a> <ul id="toc-Gallbladder_Adenomyoma_4-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Treatment" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Treatment"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Treatment</span> </div> </a> <button aria-controls="toc-Treatment-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Treatment subsection</span> </button> <ul id="toc-Treatment-sublist" class="vector-toc-list"> <li id="toc-Uterine_Adenomyoma_5" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Uterine_Adenomyoma_5"> <div class="vector-toc-text"> <span class="vector-toc-numb">5.1</span> <span>Uterine Adenomyoma</span> </div> </a> <ul id="toc-Uterine_Adenomyoma_5-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Extrauterine_Adenomyoma_5" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Extrauterine_Adenomyoma_5"> <div class="vector-toc-text"> <span class="vector-toc-numb">5.2</span> <span>Extrauterine Adenomyoma</span> </div> </a> <ul id="toc-Extrauterine_Adenomyoma_5-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Gallbladder_Adenomyoma_5" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Gallbladder_Adenomyoma_5"> <div class="vector-toc-text"> <span class="vector-toc-numb">5.3</span> <span>Gallbladder Adenomyoma</span> </div> </a> <ul id="toc-Gallbladder_Adenomyoma_5-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Prognosis" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Prognosis"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>Prognosis</span> </div> </a> <button aria-controls="toc-Prognosis-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Prognosis subsection</span> </button> <ul id="toc-Prognosis-sublist" class="vector-toc-list"> <li id="toc-Uterine_Adenomyoma_6" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Uterine_Adenomyoma_6"> <div class="vector-toc-text"> <span class="vector-toc-numb">6.1</span> <span>Uterine Adenomyoma</span> </div> </a> <ul id="toc-Uterine_Adenomyoma_6-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Extrauterine_Adenomyoma_6" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Extrauterine_Adenomyoma_6"> <div class="vector-toc-text"> <span class="vector-toc-numb">6.2</span> <span>Extrauterine Adenomyoma</span> </div> </a> <ul id="toc-Extrauterine_Adenomyoma_6-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Gallbladder_Adenomyoma_6" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Gallbladder_Adenomyoma_6"> <div class="vector-toc-text"> <span class="vector-toc-numb">6.3</span> <span>Gallbladder Adenomyoma</span> </div> </a> <ul id="toc-Gallbladder_Adenomyoma_6-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Epidemiology" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Epidemiology"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> <span>Epidemiology</span> </div> </a> <button aria-controls="toc-Epidemiology-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Epidemiology subsection</span> </button> <ul id="toc-Epidemiology-sublist" class="vector-toc-list"> <li id="toc-Uterine_Adenomyoma_7" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Uterine_Adenomyoma_7"> <div class="vector-toc-text"> <span class="vector-toc-numb">7.1</span> <span>Uterine Adenomyoma</span> </div> </a> <ul id="toc-Uterine_Adenomyoma_7-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Extrauterine_Adenomyoma_7" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Extrauterine_Adenomyoma_7"> <div class="vector-toc-text"> <span class="vector-toc-numb">7.2</span> <span>Extrauterine Adenomyoma</span> </div> </a> <ul id="toc-Extrauterine_Adenomyoma_7-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Gallbladder_Adenomyoma_7" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Gallbladder_Adenomyoma_7"> <div class="vector-toc-text"> <span class="vector-toc-numb">7.3</span> <span>Gallbladder Adenomyoma</span> </div> </a> <ul id="toc-Gallbladder_Adenomyoma_7-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-See_also" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#See_also"> <div class="vector-toc-text"> <span class="vector-toc-numb">8</span> <span>See also</span> </div> </a> <ul id="toc-See_also-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> <span class="vector-toc-numb">9</span> <span>References</span> </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-External_links" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#External_links"> <div class="vector-toc-text"> <span class="vector-toc-numb">10</span> <span>External links</span> </div> </a> <ul id="toc-External_links-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Contents" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" 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href="https://de.wikipedia.org/wiki/Adenomyom" title="Adenomyom – German" lang="de" hreflang="de" data-title="Adenomyom" data-language-autonym="Deutsch" data-language-local-name="German" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Adenomyoma" title="Adenomyoma – Indonesian" lang="id" hreflang="id" data-title="Adenomyoma" data-language-autonym="Bahasa Indonesia" data-language-local-name="Indonesian" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-ml mw-list-item"><a href="https://ml.wikipedia.org/wiki/%E0%B4%85%E0%B4%A1%E0%B4%BF%E0%B4%A8%E0%B5%8B%E0%B4%AE%E0%B4%AF%E0%B5%8B%E0%B4%AE" title="അഡിനോമയോമ – Malayalam" lang="ml" hreflang="ml" data-title="അഡിനോമയോമ" data-language-autonym="മലയാളം" data-language-local-name="Malayalam" class="interlanguage-link-target"><span>മലയാളം</span></a></li><li class="interlanguage-link interwiki-uz mw-list-item"><a href="https://uz.wikipedia.org/wiki/Adenomioma" title="Adenomioma – Uzbek" lang="uz" hreflang="uz" data-title="Adenomioma" data-language-autonym="Oʻzbekcha / ўзбекча" data-language-local-name="Uzbek" class="interlanguage-link-target"><span>Oʻzbekcha / ўзбекча</span></a></li><li class="interlanguage-link interwiki-tg mw-list-item"><a href="https://tg.wikipedia.org/wiki/%D0%90%D0%B4%D0%B5%D0%BD%D0%BE%D0%BC%D0%B8%D0%BE%D0%BC%D0%B0" title="Аденомиома – Tajik" lang="tg" hreflang="tg" data-title="Аденомиома" data-language-autonym="Тоҷикӣ" data-language-local-name="Tajik" class="interlanguage-link-target"><span>Тоҷикӣ</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E8%85%BA%E8%82%8C%E7%98%A4" title="腺肌瘤 – Chinese" lang="zh" hreflang="zh" data-title="腺肌瘤" data-language-autonym="中文" data-language-local-name="Chinese" class="interlanguage-link-target"><span>中文</span></a></li> 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<div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Medical condition</div><style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox ib-medical-condition"><tbody><tr><th colspan="2" class="infobox-above" style="background:#ccc">Adenomyoma</th></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Medical_specialty" title="Medical specialty">Specialty</a></th><td class="infobox-data"><a href="/wiki/Oncology" title="Oncology">Oncology</a> <span class="penicon autoconfirmed-show"><span class="mw-valign-text-top" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q4682249?uselang=en#P1995" title="Edit this on Wikidata"><img alt="Edit this on Wikidata" src="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></span></td></tr></tbody></table> <p><b>Adenomyoma</b> is a tumor (<i>-oma</i>) including components derived from <a href="/wiki/Gland" title="Gland">glands</a> (<i>adeno-</i>) and <a href="/wiki/Muscle" title="Muscle">muscle</a> (<i>-my-</i>).<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> It is a type of <a href="/wiki/Complex_and_mixed_tumor" class="mw-redirect" title="Complex and mixed tumor">complex and mixed tumor</a>, and several variants have been described in the medical literature. <a href="/wiki/Uterus" title="Uterus">Uterine</a> adenomyoma, the localized form of uterine <a href="/wiki/Adenomyosis" title="Adenomyosis">adenomyosis</a>, is a tumor composed of <a href="/wiki/Endometrium" title="Endometrium">endometrial gland tissue</a> and <a href="/wiki/Smooth_muscle" title="Smooth muscle">smooth muscle</a> in the <a href="/wiki/Myometrium" title="Myometrium">myometrium</a>.<sup id="cite_ref-:0_2-0" class="reference"><a href="#cite_note-:0-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> Adenomyomas containing endometrial glands are also found outside of the uterus, most commonly on <a href="/wiki/Adnexa_of_the_uterus" class="mw-redirect" title="Adnexa of the uterus">the uterine adnexa</a> but can also develop at distant sites outside of the <a href="/wiki/Pelvis" title="Pelvis">pelvis</a>.<sup id="cite_ref-:1_3-0" class="reference"><a href="#cite_note-:1-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Gallbladder" title="Gallbladder">Gallbladder</a> adenomyoma, the localized form of <a href="/wiki/Adenomyomatosis" title="Adenomyomatosis">adenomyomatosis</a>, is a <a href="/wiki/Polyp_(medicine)" title="Polyp (medicine)">polypoid tumor</a> in the gallbladder composed of <a href="/wiki/Hyperplasia" title="Hyperplasia">hyperplastic</a> <a href="/wiki/Mucous_membrane" title="Mucous membrane">mucosal epithelium</a> and <a href="/wiki/Muscularis_propria" class="mw-redirect" title="Muscularis propria">muscularis propria</a>.<sup id="cite_ref-:3_4-0" class="reference"><a href="#cite_note-:3-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:4_5-0" class="reference"><a href="#cite_note-:4-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:5_6-0" class="reference"><a href="#cite_note-:5-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Classification">Classification</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Adenomyoma&action=edit&section=1" title="Edit section: Classification"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-halign-left" typeof="mw:File/Thumb"><a href="/wiki/File:Uterine_adenomyosis_--_very_high_mag.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a3/Uterine_adenomyosis_--_very_high_mag.jpg/200px-Uterine_adenomyosis_--_very_high_mag.jpg" decoding="async" width="200" height="300" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a3/Uterine_adenomyosis_--_very_high_mag.jpg/300px-Uterine_adenomyosis_--_very_high_mag.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a3/Uterine_adenomyosis_--_very_high_mag.jpg/400px-Uterine_adenomyosis_--_very_high_mag.jpg 2x" data-file-width="2848" data-file-height="4272" /></a><figcaption>High magnification micrograph of uterine adenomyoma.</figcaption></figure> <div class="mw-heading mw-heading3"><h3 id="Uterine_Adenomyoma">Uterine Adenomyoma</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Adenomyoma&action=edit&section=2" title="Edit section: Uterine Adenomyoma"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Uterine adenomyoma is the focal form of uterine <a href="/wiki/Adenomyosis" title="Adenomyosis">adenomyosis</a>. Adenomyosis most commonly presents with numerous small collections of <a href="/wiki/Endometrium" title="Endometrium">endometrial glands</a> and <a href="/wiki/Stromal_cell" title="Stromal cell">stroma</a> spread diffusely throughout the <a href="/wiki/Myometrium" title="Myometrium">myometrium</a>, intermixed with the myometrial <a href="/wiki/Smooth_muscle" title="Smooth muscle">smooth muscle</a>. In contrast, a uterine adenomyoma is an isolated nodular mass of endometrial tissue with surrounding smooth muscle, either embedded within the myometrium or extending from the endometrium into the <a href="/wiki/Uterine_cavity" title="Uterine cavity">uterine cavity</a> in the form of a <a href="/wiki/Polyp_(medicine)" title="Polyp (medicine)">polyp</a>.<sup id="cite_ref-:0_2-1" class="reference"><a href="#cite_note-:0-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Extrauterine_Adenomyoma">Extrauterine Adenomyoma</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Adenomyoma&action=edit&section=3" title="Edit section: Extrauterine Adenomyoma"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Though less common, adenomyomas with endometrial tissue can also be found outside the uterus. The majority of cases of extrauterine adenomyomas described in the literature have been located in the pelvis, growing on the <a href="/wiki/Ovary" title="Ovary">ovaries</a>, uterine <a href="/wiki/Ligament" title="Ligament">ligaments</a>, and space surrounding the rectum.<sup id="cite_ref-:1_3-1" class="reference"><a href="#cite_note-:1-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> Several cases have been located outside of the pelvis, such as in the liver, appendix, upper abdomen, and <a href="/wiki/Mesentery" title="Mesentery">mesentery</a> of the small bowel. There have also been patients with adenomyomas found at multiple locations in the body.<sup id="cite_ref-:1_3-2" class="reference"><a href="#cite_note-:1-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Gallbladder_Adenomyoma">Gallbladder Adenomyoma</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Adenomyoma&action=edit&section=4" title="Edit section: Gallbladder Adenomyoma"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Gallbladder <a href="/wiki/Adenomyomatosis" title="Adenomyomatosis">adenomyomatosis</a> is a <a href="/wiki/Benign_tumor" title="Benign tumor">benign</a> disease of the gallbladder characterized by <a href="/wiki/Hyperplasia" title="Hyperplasia">hyperplasia</a> of the <a href="/wiki/Mucous_membrane" title="Mucous membrane">mucosal epithelium</a> and smooth muscle cells inside the <a href="/wiki/Muscular_layer" title="Muscular layer">muscularis propria</a>.<sup id="cite_ref-:3_4-1" class="reference"><a href="#cite_note-:3-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:4_5-1" class="reference"><a href="#cite_note-:4-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:5_6-1" class="reference"><a href="#cite_note-:5-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> The excessive proliferation of epithelial cells causes the mucosa to invaginate into the muscular layer lining the gallbladder wall, resulting in characteristic <a href="/wiki/Diverticulum" title="Diverticulum">diverticula</a> known as Rokitansky-Aschoff sinuses. These sinuses may be filled with <a href="/wiki/Biliary_sludge" title="Biliary sludge">biliary sludge</a>, <a href="/wiki/Cholesterol_crystal" title="Cholesterol crystal">cholesterol crystals</a>, or <a href="/wiki/Gallstone" title="Gallstone">gallstones</a>.<sup id="cite_ref-:3_4-2" class="reference"><a href="#cite_note-:3-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:4_5-2" class="reference"><a href="#cite_note-:4-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:5_6-2" class="reference"><a href="#cite_note-:5-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p><p>There are three morphologic variants described in the literature – diffuse, segmental, and localized.<sup id="cite_ref-:4_5-3" class="reference"><a href="#cite_note-:4-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:5_6-3" class="reference"><a href="#cite_note-:5-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> Diffuse, also known as generalized, adenomyomatosis has a widespread distribution of hyperplastic changes and thickening across the gallbladder wall.<sup id="cite_ref-:4_5-4" class="reference"><a href="#cite_note-:4-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:5_6-4" class="reference"><a href="#cite_note-:5-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> The localized form of adenomyomatosis is also known as a gallbladder adenomyoma (in a similar manner that uterine adenomyoma is the localized variant of adenomyosis). The localized form is a single mass, typically in the <a href="/wiki/Fundus_of_gallbladder" class="mw-redirect" title="Fundus of gallbladder">fundus</a>, that protrudes into the <a href="/wiki/Lumen_(anatomy)" title="Lumen (anatomy)">lumen</a> of the gallbladder in the form of a polyp.<sup id="cite_ref-:4_5-5" class="reference"><a href="#cite_note-:4-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:5_6-5" class="reference"><a href="#cite_note-:5-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> The segmental form is characterized by its annular (ring-shaped) distribution of adenomyomatosis in the <a href="/wiki/Body_of_gallbladder" class="mw-redirect" title="Body of gallbladder">body</a> of the gallbladder, often giving it an hourglass-like appearance.<sup id="cite_ref-:4_5-6" class="reference"><a href="#cite_note-:4-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:5_6-6" class="reference"><a href="#cite_note-:5-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Signs_and_symptoms">Signs and symptoms</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Adenomyoma&action=edit&section=5" title="Edit section: Signs and symptoms"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Uterine_Adenomyoma_2">Uterine Adenomyoma</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Adenomyoma&action=edit&section=6" title="Edit section: Uterine Adenomyoma"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The clinical features of uterine adenomyosis vary widely and may include <a href="/wiki/Dysmenorrhea" title="Dysmenorrhea">dysmenorrhea</a>, <a href="/wiki/Pelvic_pain" title="Pelvic pain">pelvic pain</a>, <a href="/wiki/Heavy_menstrual_bleeding" title="Heavy menstrual bleeding">menorrhagia</a>, and/or <a href="/wiki/Infertility" title="Infertility">infertility</a>, with about one in three affected women remaining asymptomatic.<sup id="cite_ref-:0_2-2" class="reference"><a href="#cite_note-:0-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> Women with uterine adenomyomas (focal adenomyosis) more commonly have co-existing <a href="/wiki/Endometriosis" title="Endometriosis">endometriosis</a> and a higher likelihood of infertility compared to women presenting with diffuse adenomyosis. However, a causal link between adenomyomas and the development of infertility has not been established, and further investigation is needed.<sup id="cite_ref-:0_2-3" class="reference"><a href="#cite_note-:0-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Extrauterine_Adenomyoma_2">Extrauterine Adenomyoma</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Adenomyoma&action=edit&section=7" title="Edit section: Extrauterine Adenomyoma"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The most frequent complaint in cases of extrauterine adenomyomas is pain in the pelvis or abdomen, with a small proportion of women also presenting with <a href="/wiki/Vaginal_bleeding" title="Vaginal bleeding">abnormal bleeding</a> and/or infertility.<sup id="cite_ref-:1_3-3" class="reference"><a href="#cite_note-:1-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> In half the cases described in the literature, the patient had a history of gynecologic surgery before diagnosis, and several patients also had a medical history of endometriosis.<sup id="cite_ref-:1_3-4" class="reference"><a href="#cite_note-:1-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Gallbladder_Adenomyoma_2">Gallbladder Adenomyoma</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Adenomyoma&action=edit&section=8" title="Edit section: Gallbladder Adenomyoma"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Most patients with adenomyomatosis are asymptomatic.<sup id="cite_ref-:3_4-3" class="reference"><a href="#cite_note-:3-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:4_5-7" class="reference"><a href="#cite_note-:4-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:5_6-7" class="reference"><a href="#cite_note-:5-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> Among symptomatic patients, the most common symptom is abdominal pain in the right upper quadrant or epigastrium. Patients may also present with nausea, dyspepsia, or fatty food intolerance, likely due to altered flow of bile.<sup id="cite_ref-:4_5-8" class="reference"><a href="#cite_note-:4-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> Some data suggest that the features of clinical presentation may frequently differ based on the variant of adenomyomatosis, as the diffuse and segmental forms appear to have more significant inflammation and a higher incidence of gallstones compared to the localized form.<sup id="cite_ref-:4_5-9" class="reference"><a href="#cite_note-:4-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> Other symptoms are often related to frequently co-occurring gallbladder diseases such as gallstones, cholecystitis, and choledocholithiasis. These may present with fever, pain, <a href="/wiki/Jaundice" title="Jaundice">jaundice</a>, or other symptoms.<sup id="cite_ref-:4_5-10" class="reference"><a href="#cite_note-:4-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Causes">Causes</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Adenomyoma&action=edit&section=9" title="Edit section: Causes"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Uterine_Adenomyoma_3">Uterine Adenomyoma</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Adenomyoma&action=edit&section=10" title="Edit section: Uterine Adenomyoma"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The underlying cause is not fully understood. A prominent theory is the invagination theory, in which tissue injuries and <a href="/wiki/Inflammation" title="Inflammation">inflammatory changes</a> due to chronic uterine contractions allow endometrial tissue to pass into the neighboring myometrium.<sup id="cite_ref-:0_2-4" class="reference"><a href="#cite_note-:0-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> Based on differences in the <a href="/wiki/Protein" title="Protein">proteins</a> expressed in adenomyomas located in the inner part of the myometrium versus the outer part of the myometrium, it is possible that adenomyomas can also result from the invasion of <a href="/wiki/Ectopia_(medicine)" title="Ectopia (medicine)">ectopic</a> endometrial cells originating from nearby regions of endometriosis.<sup id="cite_ref-:0_2-5" class="reference"><a href="#cite_note-:0-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Extrauterine_Adenomyoma_3">Extrauterine Adenomyoma</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Adenomyoma&action=edit&section=11" title="Edit section: Extrauterine Adenomyoma"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>No exact risk factors have been described for adenomyomas that develop outside the uterus.<sup id="cite_ref-:1_3-5" class="reference"><a href="#cite_note-:1-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> A history of prolonged hormone therapy is reported in two cases of patients diagnosed with an extrauterine adenomyoma, including <a href="/wiki/Estrogen" title="Estrogen">estrogen</a> and a <a href="/wiki/Gonadotropin-releasing_hormone" title="Gonadotropin-releasing hormone">gonadotropin releasing hormone (GnRH)</a> agonist. Though adenomyosis has demonstrated sensitivity to estrogen, further investigation is needed to explore the relationship between hormone therapy and extrauterine adenomyomas.<sup id="cite_ref-:1_3-6" class="reference"><a href="#cite_note-:1-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p><p>Several theories have been hypothesized to explain the pathogenesis. One theory describes extrauterine adenomyomas resulting from an error in <a href="/wiki/Paramesonephric_duct" title="Paramesonephric duct">Müllerian duct</a> fusion during embryonic development, resulting in an abnormal uterus containing a horn-like structure.<sup id="cite_ref-:1_3-7" class="reference"><a href="#cite_note-:1-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> This horn may then be prone to breaking away and depositing elsewhere, later developing into an adenomyoma. As errors in Müllerian duct fusion also impact the development of the kidneys, urinary tract, and genitals, this theory would explain the multiple cases of extrauterine adenomyomas with co-existing <a href="/wiki/Birth_defect" title="Birth defect">congenital abnormalities</a> of these anatomic structures.<sup id="cite_ref-:1_3-8" class="reference"><a href="#cite_note-:1-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p><p>Another theory suggests that extrauterine adenomyomas may result from smooth muscle <a href="/wiki/Metaplasia" title="Metaplasia">metaplasia</a> in areas of pre-existing endometriosis. In this theory, areas of endometrial tissue that have developed outside the uterus (endometriosis) undergo cellular changes that provide the muscular component of the adenomyoma.<sup id="cite_ref-:1_3-9" class="reference"><a href="#cite_note-:1-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Gallbladder_Adenomyoma_3">Gallbladder Adenomyoma</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Adenomyoma&action=edit&section=12" title="Edit section: Gallbladder Adenomyoma"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The specific cause of gallbladder adenomyomatosis remains unclear.<sup id="cite_ref-:3_4-4" class="reference"><a href="#cite_note-:3-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:4_5-11" class="reference"><a href="#cite_note-:4-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:5_6-8" class="reference"><a href="#cite_note-:5-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> Some of the risk factors for gallstone formation have also been reported in patients with adenomyomatosis such as <a href="/wiki/Hemolytic_anemia" title="Hemolytic anemia">hemolytic disease</a>, congenital <a href="/wiki/Biliary_tract" title="Biliary tract">biliary</a> abnormalities, obesity, and <a href="/wiki/Inflammatory_bowel_disease" title="Inflammatory bowel disease">inflammatory bowel disease</a>, but whether these are also risk factors for adenomyomatosis requires further investigation.<sup id="cite_ref-:5_6-9" class="reference"><a href="#cite_note-:5-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p><p>The disease is currently thought to be a <a href="/wiki/Degenerative_disease" title="Degenerative disease">degenerative process</a> and unlikely to be the result of congenital malformation.<sup id="cite_ref-:4_5-12" class="reference"><a href="#cite_note-:4-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:5_6-10" class="reference"><a href="#cite_note-:5-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> The cell proliferation seen in adenomyomatosis is theorized to result from increased pressure inside the gallbladder due to abnormal muscle contractions or excessive absorption of bile by the gallbladder wall.<sup id="cite_ref-:4_5-13" class="reference"><a href="#cite_note-:4-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:5_6-11" class="reference"><a href="#cite_note-:5-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Diagnosis">Diagnosis</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Adenomyoma&action=edit&section=13" title="Edit section: Diagnosis"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Uterine_Adenomyoma_4">Uterine Adenomyoma</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Adenomyoma&action=edit&section=14" title="Edit section: Uterine Adenomyoma"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure typeof="mw:File/Thumb"><a href="/wiki/File:Uterine_adenomyosis_--_intermed_mag.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Uterine_adenomyosis_--_intermed_mag.jpg/264px-Uterine_adenomyosis_--_intermed_mag.jpg" decoding="async" width="264" height="176" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Uterine_adenomyosis_--_intermed_mag.jpg/396px-Uterine_adenomyosis_--_intermed_mag.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/65/Uterine_adenomyosis_--_intermed_mag.jpg/528px-Uterine_adenomyosis_--_intermed_mag.jpg 2x" data-file-width="4272" data-file-height="2848" /></a><figcaption>Histopathology of uterine adenomyosis. H&E stain.</figcaption></figure> <p>The most common diagnostic imaging modalities for uterine adenomyosis include <a href="/wiki/Vaginal_ultrasonography" title="Vaginal ultrasonography">transvaginal ultrasonography</a> (TVS) and <a href="/wiki/Magnetic_resonance_imaging" title="Magnetic resonance imaging">magnetic resonance imaging</a> (MRI). Though surgical excision and microscopic examination of the tumor allow for a definitive diagnosis, these imaging studies offer a non-invasive approach and have a sufficient resolution for a diagnosis.<sup id="cite_ref-:0_2-6" class="reference"><a href="#cite_note-:0-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> </p><p>Diagnosis with transvaginal ultrasonography can potentially be challenging due to the similar appearance of <a href="/wiki/Uterine_fibroid" title="Uterine fibroid">uterine leiomyomas</a> (also known as uterine fibroids). Careful evaluation of the margins of the mass, the vascular flow patterns through the tumor, and the degree to which the tumor distorts the uterus may aid in differentiating these masses with ultrasound.<sup id="cite_ref-:0_2-7" class="reference"><a href="#cite_note-:0-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> MRI is highly effective at distinguishing between uterine adenomyomas and leiomyomas.<sup id="cite_ref-:1_3-10" class="reference"><a href="#cite_note-:1-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Extrauterine_Adenomyoma_4">Extrauterine Adenomyoma</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Adenomyoma&action=edit&section=15" title="Edit section: Extrauterine Adenomyoma"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure typeof="mw:File/Thumb"><a href="/wiki/File:Adenomyoma_of_the_Ovary_(Smooth_Muscle_Actin_Immunostain)_(4974731463).jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/e/e6/Adenomyoma_of_the_Ovary_%28Smooth_Muscle_Actin_Immunostain%29_%284974731463%29.jpg/266px-Adenomyoma_of_the_Ovary_%28Smooth_Muscle_Actin_Immunostain%29_%284974731463%29.jpg" decoding="async" width="266" height="177" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/e6/Adenomyoma_of_the_Ovary_%28Smooth_Muscle_Actin_Immunostain%29_%284974731463%29.jpg/399px-Adenomyoma_of_the_Ovary_%28Smooth_Muscle_Actin_Immunostain%29_%284974731463%29.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/e6/Adenomyoma_of_the_Ovary_%28Smooth_Muscle_Actin_Immunostain%29_%284974731463%29.jpg/532px-Adenomyoma_of_the_Ovary_%28Smooth_Muscle_Actin_Immunostain%29_%284974731463%29.jpg 2x" data-file-width="1636" data-file-height="1089" /></a><figcaption>Adenomyoma of the ovary. Smooth muscle actin immunostain.</figcaption></figure> <p>The most common imaging techniques include ultrasound, <a href="/wiki/CT_scan" title="CT scan">computed tomography</a> (CT), and MRI. <a href="/wiki/Pyelogram" title="Pyelogram">Intravenous pyelography</a> (IVP) has also been used in some cases to assess for possible congenital anomalies of the kidneys.<sup id="cite_ref-:1_3-11" class="reference"><a href="#cite_note-:1-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> The appearance of these rare tumors on diagnostic imaging has not been extensively described, and in each case documented in the literature, the diagnosis was ultimately made after surgical removal using <a href="/wiki/Histology" title="Histology">histologic</a> analysis.<sup id="cite_ref-:1_3-12" class="reference"><a href="#cite_note-:1-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p><p>On microscopic examination, patterns of smooth muscle and endometrial tissue must be assessed with care to differentiate adenomyomas from masses of similar appearances, such as endometriosis containing smooth muscle and leiomyomas containing endometriosis.<sup id="cite_ref-:1_3-13" class="reference"><a href="#cite_note-:1-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Gallbladder_Adenomyoma_4">Gallbladder Adenomyoma</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Adenomyoma&action=edit&section=16" title="Edit section: Gallbladder Adenomyoma"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure typeof="mw:File/Thumb"><a href="/wiki/File:Rokitansky-Aschoff_Sinus,_Gallbladder_(3704042567).jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/7/75/Rokitansky-Aschoff_Sinus%2C_Gallbladder_%283704042567%29.jpg/267px-Rokitansky-Aschoff_Sinus%2C_Gallbladder_%283704042567%29.jpg" decoding="async" width="267" height="178" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/75/Rokitansky-Aschoff_Sinus%2C_Gallbladder_%283704042567%29.jpg/401px-Rokitansky-Aschoff_Sinus%2C_Gallbladder_%283704042567%29.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/75/Rokitansky-Aschoff_Sinus%2C_Gallbladder_%283704042567%29.jpg/534px-Rokitansky-Aschoff_Sinus%2C_Gallbladder_%283704042567%29.jpg 2x" data-file-width="1725" data-file-height="1150" /></a><figcaption><b>Rokitansky-Aschoff Sinus, Gallbladder Adenomyomatosis</b></figcaption></figure> <p>Adenomyomatosis is frequently associated with gallstones and is often diagnosed incidentally, either from a <a href="/wiki/Cholecystectomy" title="Cholecystectomy">cholecystectomy</a> specimen or <a href="/wiki/Autopsy" title="Autopsy">autopsy</a>.<sup id="cite_ref-:3_4-5" class="reference"><a href="#cite_note-:3-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:4_5-14" class="reference"><a href="#cite_note-:4-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:5_6-12" class="reference"><a href="#cite_note-:5-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> No <a href="/wiki/Serology" title="Serology">serologic test</a> exists to specify adenomyomatosis and laboratory studies are often normal. Co-existing diseases like <a href="/wiki/Cholecystitis" title="Cholecystitis">cholecystitis</a> may result in abnormal test results, such as elevated levels of white blood cells (<a href="/wiki/Leukocytosis" title="Leukocytosis">leukocytosis</a>), liver enzymes (<a href="/wiki/Elevated_transaminases" title="Elevated transaminases">transaminitis</a>), or bilirubin (<a href="/wiki/Hyperbilirubinemia" class="mw-redirect" title="Hyperbilirubinemia">hyperbilirubinemia</a>).<sup id="cite_ref-:4_5-15" class="reference"><a href="#cite_note-:4-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p><p>Ultrasound is the preferred initial diagnostic choice for suspected gallbladder disease. Several distinct features of adenomyomatosis are discernable using ultrasound, making it a reliable modality for diagnosis.<sup id="cite_ref-:3_4-6" class="reference"><a href="#cite_note-:3-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:4_5-16" class="reference"><a href="#cite_note-:4-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:5_6-13" class="reference"><a href="#cite_note-:5-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> The most characteristic features seen on ultrasound are the Rokitansky-Aschoff sinuses, which present either as <a href="/wiki/Echogenicity" title="Echogenicity">echogenic</a> foci when filled with biliary sludge/gallstones or <a href="/wiki/Anechogenic" class="mw-redirect" title="Anechogenic">anechogenic</a> foci when filled with normal bile.<sup id="cite_ref-:3_4-7" class="reference"><a href="#cite_note-:3-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:4_5-17" class="reference"><a href="#cite_note-:4-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:5_6-14" class="reference"><a href="#cite_note-:5-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> Other key features that may be seen include wall thickening and ring-down <a href="/wiki/Artifact_(error)" title="Artifact (error)">artifacts</a> known as "comet tails" (produced by reverberations of sound between the sinuses).<sup id="cite_ref-:3_4-8" class="reference"><a href="#cite_note-:3-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:4_5-18" class="reference"><a href="#cite_note-:4-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:5_6-15" class="reference"><a href="#cite_note-:5-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> Ultrasound can also distinguish between diffuse, segmental, and localized variants of adenomyomatosis based on morphology.<sup id="cite_ref-:4_5-19" class="reference"><a href="#cite_note-:4-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:5_6-16" class="reference"><a href="#cite_note-:5-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p><p>In some cases, gallbladder wall thickening may be seen on ultrasound but is poorly defined and lacking specificity, particularly if the characteristic Rokitansky-Aschoff sinuses are not visualized. This can make it difficult to distinguish adenomyomatosis from other conditions that result in gallbladder wall thickening such as gallbladder cancer.<sup id="cite_ref-:3_4-9" class="reference"><a href="#cite_note-:3-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:4_5-20" class="reference"><a href="#cite_note-:4-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:5_6-17" class="reference"><a href="#cite_note-:5-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> In these cases, MRI can prove helpful in providing the resolution needed for diagnosis. Especially effective is the <a href="/wiki/T2-weighted_MRI" class="mw-redirect" title="T2-weighted MRI">T2-weighted MRI</a> at visualizing the pathognomonic Rokitansky-Aschoff sinuses, which appear as round-shaped <a href="/wiki/Hyperintensity" title="Hyperintensity">hyperintense</a> cystic spaces that align in a curvilinear fashion along the gallbladder wall in a pattern described as the ”pearl necklace sign”.<sup id="cite_ref-:3_4-10" class="reference"><a href="#cite_note-:3-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:4_5-21" class="reference"><a href="#cite_note-:4-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:5_6-18" class="reference"><a href="#cite_note-:5-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Treatment">Treatment</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Adenomyoma&action=edit&section=17" title="Edit section: Treatment"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Uterine_Adenomyoma_5">Uterine Adenomyoma</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Adenomyoma&action=edit&section=18" title="Edit section: Uterine Adenomyoma"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Multiple medical and surgical approaches have been explored to treat uterine adenomyomas, and a patient’s symptoms and reproductive preferences must be considered carefully when choosing the most appropriate therapy.<sup id="cite_ref-:0_2-8" class="reference"><a href="#cite_note-:0-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> Medical treatments include <a href="/wiki/Nonsteroidal_anti-inflammatory_drug" title="Nonsteroidal anti-inflammatory drug">nonsteroidal anti-inflammatory drugs</a> (NSAIDs) used for pelvic and menstrual pain and hormonally active medications such as <a href="/wiki/Progesterone_(medication)" title="Progesterone (medication)">progestins</a>, <a href="/wiki/Estrogen_(medication)" title="Estrogen (medication)">estrogen-containing contraceptives</a>, and <a href="/wiki/Gonadotropin-releasing_hormone_agonist" title="Gonadotropin-releasing hormone agonist">gonadotropin releasing hormone agonists</a>. These hormonal drugs target sex hormones that help govern the growth of endometrial tissue found in adenomyomas.<sup id="cite_ref-:0_2-9" class="reference"><a href="#cite_note-:0-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> </p><p>A variety of effective procedures are also available if medical therapy is unsuccessful. These include minimally invasive procedures like <a href="/wiki/High-intensity_focused_ultrasound" class="mw-redirect" title="High-intensity focused ultrasound">high-intensity focused ultrasound</a> or <a href="/wiki/Uterine_artery_embolization" title="Uterine artery embolization">uterine artery embolization</a> and more invasive options such as <a href="/wiki/Endometrial_ablation" title="Endometrial ablation">endometrial ablation</a> or <a href="/wiki/Hysterectomy" title="Hysterectomy">hysterectomy</a>.<sup id="cite_ref-:0_2-10" class="reference"><a href="#cite_note-:0-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> Adenomyomectomy, a conservative surgery that removes the localized tumor but leaves the surrounding healthy uterus intact, is a potential uterine-sparing option for women with a uterine adenomyoma who wish to preserve their fertility, as some of the previously listed interventions decrease or eliminate the probability of successful future childbearing.<sup id="cite_ref-:0_2-11" class="reference"><a href="#cite_note-:0-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> </p> <figure class="mw-default-size mw-halign-left" typeof="mw:File/Thumb"><a href="/wiki/File:Adenomyoma_of_Ovary_(gross)_(4975345020).jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/4/4c/Adenomyoma_of_Ovary_%28gross%29_%284975345020%29.jpg/220px-Adenomyoma_of_Ovary_%28gross%29_%284975345020%29.jpg" decoding="async" width="220" height="145" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/4c/Adenomyoma_of_Ovary_%28gross%29_%284975345020%29.jpg/330px-Adenomyoma_of_Ovary_%28gross%29_%284975345020%29.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/4c/Adenomyoma_of_Ovary_%28gross%29_%284975345020%29.jpg/440px-Adenomyoma_of_Ovary_%28gross%29_%284975345020%29.jpg 2x" data-file-width="3897" data-file-height="2561" /></a><figcaption>Adenomyoma of the ovary. Surgical specimen.</figcaption></figure> <div class="mw-heading mw-heading3"><h3 id="Extrauterine_Adenomyoma_5">Extrauterine Adenomyoma</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Adenomyoma&action=edit&section=19" title="Edit section: Extrauterine Adenomyoma"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Surgical intervention serves as the main diagnostic and treatment approach. The surgical technique applied for tumor excision highly depends on the mass’s location, with gynecologic surgeries such as hysterectomy and <a href="/wiki/Salpingo-oophorectomy" title="Salpingo-oophorectomy">salpingo-oophorectomy</a> a common choice for pelvic adenomyomas.<sup id="cite_ref-:1_3-14" class="reference"><a href="#cite_note-:1-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> Hormone therapy has also been combined with surgery in several cases, such as gonadotropin releasing hormone agonists, progesterone, and <a href="/wiki/Aromatase_inhibitor" title="Aromatase inhibitor">aromatase inhibitors</a>.<sup id="cite_ref-:1_3-15" class="reference"><a href="#cite_note-:1-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Gallbladder_Adenomyoma_5">Gallbladder Adenomyoma</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Adenomyoma&action=edit&section=20" title="Edit section: Gallbladder Adenomyoma"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Cholecystectomy, or surgical removal of the gallbladder, is the recommended treatment for patients with symptomatic adenomyomatosis.<sup id="cite_ref-:3_4-11" class="reference"><a href="#cite_note-:3-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:4_5-22" class="reference"><a href="#cite_note-:4-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:5_6-19" class="reference"><a href="#cite_note-:5-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> There is a lack of consensus as to the optimal management of asymptomatic patients, largely due to uncertainties about the possible role of adenomyomatosis in the development of gallbladder cancer. Several sources recommend surgery in cases where adenomyomatosis is difficult to distinguish from malignancy on diagnostic imaging.<sup id="cite_ref-:3_4-12" class="reference"><a href="#cite_note-:3-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:4_5-23" class="reference"><a href="#cite_note-:4-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:5_6-20" class="reference"><a href="#cite_note-:5-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> If well visualized diagnostically, the morphology of the lesion (diffuse/segmental/localized forms) may be an important factor in deciding between a surgical and conservative approach.<sup id="cite_ref-:4_5-24" class="reference"><a href="#cite_note-:4-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Prognosis">Prognosis</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Adenomyoma&action=edit&section=21" title="Edit section: Prognosis"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Uterine_Adenomyoma_6">Uterine Adenomyoma</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Adenomyoma&action=edit&section=22" title="Edit section: Uterine Adenomyoma"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Although several treatments have demonstrated long-term improvements in symptoms such as pelvic pain and menorrhagia, there is no clear consensus on the optimal treatment based on the type of adenomyosis, and few studies distinguish between diffuse and focal adenomyosis.<sup id="cite_ref-:0_2-12" class="reference"><a href="#cite_note-:0-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:2_7-0" class="reference"><a href="#cite_note-:2-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p><p>Though uterine-sparing surgery is not feasible for diffuse adenomyosis because of the widespread distribution of disease throughout the uterus, it is a possibility for focal adenomyosis due to the localized nature of the adenomyoma. However, these surgeries are performed with caution due to the complexity and potential for uterine rupture due to loss of tensile strength after surgery.<sup id="cite_ref-:0_2-13" class="reference"><a href="#cite_note-:0-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:2_7-1" class="reference"><a href="#cite_note-:2-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> There are a small number of studies that have demonstrated improved outcomes in pregnancy when combining conservative surgery with GnRH agonist therapy compared to either method alone.<sup id="cite_ref-:0_2-14" class="reference"><a href="#cite_note-:0-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:2_7-2" class="reference"><a href="#cite_note-:2-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p><p>Patients with adenomyosis have been found to have lower successful live birth rates and higher rates of <a href="/wiki/Miscarriage" title="Miscarriage">miscarriage</a> following <a href="/wiki/In_vitro_fertilisation" title="In vitro fertilisation">in vitro fertilization</a> (IVF) compared to those without adenomyosis.<sup id="cite_ref-:0_2-15" class="reference"><a href="#cite_note-:0-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:2_7-3" class="reference"><a href="#cite_note-:2-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> Multiple studies have investigated the impact of GnRH agonist therapy on in vitro fertilization success in patients with adenomyosis. One study assessing patients with adenomyosis receiving fresh <a href="/wiki/Embryo_transfer" title="Embryo transfer">embryo transfer</a> demonstrated different outcomes between diffuse and focal adenomyosis when treated with prolonged GnRH therapy prior to in vitro fertilization. Women with diffuse adenomyosis had higher pregnancy and live birth rates following prolonged GnRH therapy, whereas women with focal adenomyosis demonstrated no benefit.<sup id="cite_ref-:0_2-16" class="reference"><a href="#cite_note-:0-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> However, there are other studies with conflicting data based on the method of embryo transfer (such as frozen-thawed embryo transfer versus fresh embryo transfer) and no optimized treatment protocol has been established for patients with adenomyosis receiving fertility treatment.<sup id="cite_ref-:0_2-17" class="reference"><a href="#cite_note-:0-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:2_7-4" class="reference"><a href="#cite_note-:2-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p><p>In the case of juvenile cystic adenomyoma, laparoscopic enucleation results in a statistically and clinically significant reduction in dysmenorrhea, ease in any chronic pelvic pain, and low risk of recurrence.<sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Extrauterine_Adenomyoma_6">Extrauterine Adenomyoma</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Adenomyoma&action=edit&section=23" title="Edit section: Extrauterine Adenomyoma"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Long-term outcomes after treatment are sparsely represented in prior studies, though a small number of cases reported recurrence of adenomyomas after surgery. In addition, some patients with extrauterine adenomyomas, particularly of the ovaries and uterine ligaments, also presented with <a href="/wiki/Malignancy" title="Malignancy">malignant</a> growths in the ovaries or uterus.<sup id="cite_ref-:1_3-16" class="reference"><a href="#cite_note-:1-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Gallbladder_Adenomyoma_6">Gallbladder Adenomyoma</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Adenomyoma&action=edit&section=24" title="Edit section: Gallbladder Adenomyoma"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Though itself considered a benign disease, the potential role of gallbladder adenomyomatosis in the <a href="/wiki/Carcinogenesis" title="Carcinogenesis">carcinogenesis</a> of gallbladder cancer remains unclear.<sup id="cite_ref-:3_4-13" class="reference"><a href="#cite_note-:3-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:4_5-25" class="reference"><a href="#cite_note-:4-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:5_6-21" class="reference"><a href="#cite_note-:5-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> Previous studies have highlighted several cases of adenomyomatosis associated with gallbladder malignancy, with a particularly strong correlation between segmental adenomyomatosis and <a href="/wiki/Gallbladder_carcinoma" class="mw-redirect" title="Gallbladder carcinoma">gallbladder carcinoma</a>.<sup id="cite_ref-:4_5-26" class="reference"><a href="#cite_note-:4-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> Further studies are required to further elucidate the relationship between adenomyomatosis and cancer. </p> <div class="mw-heading mw-heading2"><h2 id="Epidemiology">Epidemiology</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Adenomyoma&action=edit&section=25" title="Edit section: Epidemiology"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Uterine_Adenomyoma_7">Uterine Adenomyoma</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Adenomyoma&action=edit&section=26" title="Edit section: Uterine Adenomyoma"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Data collected from over 300,000 women in the United States suggest an <a href="/wiki/Incidence_(epidemiology)" title="Incidence (epidemiology)">incidence</a> of about 1% for adenomyosis.<sup id="cite_ref-:0_2-18" class="reference"><a href="#cite_note-:0-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> The <a href="/wiki/Demography" title="Demography">demographic</a> with the highest incidence in this <a href="/wiki/Retrospective_cohort_study" title="Retrospective cohort study">retrospective cohort study</a> were black women and women aged 40–45 years, with women in their early 40s the most likely to be symptomatic.<sup id="cite_ref-:0_2-19" class="reference"><a href="#cite_note-:0-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Extrauterine_Adenomyoma_7">Extrauterine Adenomyoma</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Adenomyoma&action=edit&section=27" title="Edit section: Extrauterine Adenomyoma"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Much less common than the intrauterine counterpart, one review found 34 cases of extrauterine adenomyoma described in the literature.<sup id="cite_ref-:1_3-17" class="reference"><a href="#cite_note-:1-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> The ages of affected women at diagnosis have had a wide range from 17 to 70 years.<sup id="cite_ref-:1_3-18" class="reference"><a href="#cite_note-:1-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Gallbladder_Adenomyoma_7">Gallbladder Adenomyoma</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Adenomyoma&action=edit&section=28" title="Edit section: Gallbladder Adenomyoma"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Adenomyomatosis is discovered in approximately 5% of cholecystectomy specimens.<sup id="cite_ref-:3_4-14" class="reference"><a href="#cite_note-:3-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:4_5-27" class="reference"><a href="#cite_note-:4-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:5_6-22" class="reference"><a href="#cite_note-:5-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> Most patients who are diagnosed are in their 50s or older,<sup id="cite_ref-:3_4-15" class="reference"><a href="#cite_note-:3-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:4_5-28" class="reference"><a href="#cite_note-:4-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:5_6-23" class="reference"><a href="#cite_note-:5-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> with a rare few cases found in children.<sup id="cite_ref-:4_5-29" class="reference"><a href="#cite_note-:4-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:5_6-24" class="reference"><a href="#cite_note-:5-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Adenomyoma&action=edit&section=29" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Atypical_polypoid_adenomyoma" title="Atypical polypoid adenomyoma">Atypical polypoid adenomyoma</a></li> <li><a href="/wiki/Adenomyosis" title="Adenomyosis">Adenomyosis</a></li> <li><a href="/wiki/Adenomyomatosis" title="Adenomyomatosis">Adenomyomatosis</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Adenomyoma&action=edit&section=30" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-1">^</a></b></span> <span class="reference-text"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20090628224336/http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/one/000001684.htm">"adenomyoma"</a> at <i><a href="/wiki/Dorland%27s_medical_reference_works" title="Dorland's medical reference works">Dorland's Medical Dictionary</a></i></span> </li> <li id="cite_note-:0-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-:0_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-:0_2-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-:0_2-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-:0_2-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-:0_2-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-:0_2-5"><sup><i><b>f</b></i></sup></a> <a href="#cite_ref-:0_2-6"><sup><i><b>g</b></i></sup></a> <a href="#cite_ref-:0_2-7"><sup><i><b>h</b></i></sup></a> <a href="#cite_ref-:0_2-8"><sup><i><b>i</b></i></sup></a> <a href="#cite_ref-:0_2-9"><sup><i><b>j</b></i></sup></a> <a href="#cite_ref-:0_2-10"><sup><i><b>k</b></i></sup></a> <a href="#cite_ref-:0_2-11"><sup><i><b>l</b></i></sup></a> <a href="#cite_ref-:0_2-12"><sup><i><b>m</b></i></sup></a> <a href="#cite_ref-:0_2-13"><sup><i><b>n</b></i></sup></a> <a href="#cite_ref-:0_2-14"><sup><i><b>o</b></i></sup></a> <a href="#cite_ref-:0_2-15"><sup><i><b>p</b></i></sup></a> <a href="#cite_ref-:0_2-16"><sup><i><b>q</b></i></sup></a> <a href="#cite_ref-:0_2-17"><sup><i><b>r</b></i></sup></a> <a href="#cite_ref-:0_2-18"><sup><i><b>s</b></i></sup></a> <a href="#cite_ref-:0_2-19"><sup><i><b>t</b></i></sup></a></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite id="CITEREFLatifSaridogan2022" class="citation journal cs1">Latif, Sania; Saridogan, Ertan (2022-09-25). <a rel="nofollow" class="external text" href="https://gpm.amegroups.com/article/view/8440">"Uterine adenomyoma—what we know, and what we don't know: a narrative review"</a>. <i>Gynecology and Pelvic Medicine</i>. <b>5</b>: 25. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.21037%2Fgpm-21-50">10.21037/gpm-21-50</a></span>. <a href="/wiki/ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/2617-4499">2617-4499</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a 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href="#cite_ref-:1_3-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-:1_3-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-:1_3-5"><sup><i><b>f</b></i></sup></a> <a href="#cite_ref-:1_3-6"><sup><i><b>g</b></i></sup></a> <a href="#cite_ref-:1_3-7"><sup><i><b>h</b></i></sup></a> <a href="#cite_ref-:1_3-8"><sup><i><b>i</b></i></sup></a> <a href="#cite_ref-:1_3-9"><sup><i><b>j</b></i></sup></a> <a href="#cite_ref-:1_3-10"><sup><i><b>k</b></i></sup></a> <a href="#cite_ref-:1_3-11"><sup><i><b>l</b></i></sup></a> <a href="#cite_ref-:1_3-12"><sup><i><b>m</b></i></sup></a> <a href="#cite_ref-:1_3-13"><sup><i><b>n</b></i></sup></a> <a href="#cite_ref-:1_3-14"><sup><i><b>o</b></i></sup></a> <a href="#cite_ref-:1_3-15"><sup><i><b>p</b></i></sup></a> <a href="#cite_ref-:1_3-16"><sup><i><b>q</b></i></sup></a> <a href="#cite_ref-:1_3-17"><sup><i><b>r</b></i></sup></a> <a href="#cite_ref-:1_3-18"><sup><i><b>s</b></i></sup></a></span> <span class="reference-text"><link 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href="#cite_ref-:3_4-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-:3_4-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-:3_4-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-:3_4-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-:3_4-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-:3_4-5"><sup><i><b>f</b></i></sup></a> <a href="#cite_ref-:3_4-6"><sup><i><b>g</b></i></sup></a> <a href="#cite_ref-:3_4-7"><sup><i><b>h</b></i></sup></a> <a href="#cite_ref-:3_4-8"><sup><i><b>i</b></i></sup></a> <a href="#cite_ref-:3_4-9"><sup><i><b>j</b></i></sup></a> <a href="#cite_ref-:3_4-10"><sup><i><b>k</b></i></sup></a> <a href="#cite_ref-:3_4-11"><sup><i><b>l</b></i></sup></a> <a href="#cite_ref-:3_4-12"><sup><i><b>m</b></i></sup></a> <a href="#cite_ref-:3_4-13"><sup><i><b>n</b></i></sup></a> <a href="#cite_ref-:3_4-14"><sup><i><b>o</b></i></sup></a> <a href="#cite_ref-:3_4-15"><sup><i><b>p</b></i></sup></a></span> <span class="reference-text"><link 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href="https://doi.org/10.1007%2Fs43032-021-00818-6">10.1007/s43032-021-00818-6</a>. <a href="/wiki/ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/1933-7191">1933-7191</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/34981458">34981458</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:245654611">245654611</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Reproductive+Sciences&rft.atitle=The+Effect+of+Uterine+Adenomyosis+on+IVF+Outcomes%3A+a+Systematic+Review+and+Meta-analysis&rft.volume=29&rft.issue=11&rft.pages=3177-3193&rft.date=2022-11&rft.issn=1933-7191&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A245654611%23id-name%3DS2CID&rft_id=info%3Apmid%2F34981458&rft_id=info%3Adoi%2F10.1007%2Fs43032-021-00818-6&rft.aulast=Cozzolino&rft.aufirst=Mauro&rft.au=Tartaglia%2C+Silvio&rft.au=Pellegrini%2C+Livia&rft.au=Troiano%2C+Gianmarco&rft.au=Rizzo%2C+Giuseppe&rft.au=Petraglia%2C+Felice&rft_id=https%3A%2F%2Flink.springer.com%2F10.1007%2Fs43032-021-00818-6&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAdenomyoma" class="Z3988"></span></span> </li> <li id="cite_note-8"><span class="mw-cite-backlink"><b><a href="#cite_ref-8">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFTakeuchiKitadeKikuchiKumakiri2009" class="citation journal cs1">Takeuchi H, Kitade M, Kikuchi I, Kumakiri J, Kuroda K, Jinushi M (June 2009). "Diagnosis, laparoscopic management, and histopathologic findings of juvenile cystic adenomyoma: a review of nine cases". <i>Fertil. Steril</i>. <b>94</b> (3): 862–868. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.fertnstert.2009.05.010">10.1016/j.fertnstert.2009.05.010</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/19539912">19539912</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Fertil.+Steril.&rft.atitle=Diagnosis%2C+laparoscopic+management%2C+and+histopathologic+findings+of+juvenile+cystic+adenomyoma%3A+a+review+of+nine+cases&rft.volume=94&rft.issue=3&rft.pages=862-868&rft.date=2009-06&rft_id=info%3Adoi%2F10.1016%2Fj.fertnstert.2009.05.010&rft_id=info%3Apmid%2F19539912&rft.aulast=Takeuchi&rft.aufirst=H&rft.au=Kitade%2C+M&rft.au=Kikuchi%2C+I&rft.au=Kumakiri%2C+J&rft.au=Kuroda%2C+K&rft.au=Jinushi%2C+M&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAdenomyoma" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Adenomyoma&action=edit&section=31" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div 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dt::after{content:": "}.mw-parser-output .hlist dd::after,.mw-parser-output .hlist li::after{content:" · ";font-weight:bold}.mw-parser-output .hlist dd:last-child::after,.mw-parser-output .hlist dt:last-child::after,.mw-parser-output .hlist li:last-child::after{content:none}.mw-parser-output .hlist dd dd:first-child::before,.mw-parser-output .hlist dd dt:first-child::before,.mw-parser-output .hlist dd li:first-child::before,.mw-parser-output .hlist dt dd:first-child::before,.mw-parser-output .hlist dt dt:first-child::before,.mw-parser-output .hlist dt li:first-child::before,.mw-parser-output .hlist li dd:first-child::before,.mw-parser-output .hlist li dt:first-child::before,.mw-parser-output .hlist li li:first-child::before{content:" (";font-weight:normal}.mw-parser-output .hlist dd dd:last-child::after,.mw-parser-output .hlist dd dt:last-child::after,.mw-parser-output .hlist dd li:last-child::after,.mw-parser-output .hlist dt dd:last-child::after,.mw-parser-output .hlist dt dt:last-child::after,.mw-parser-output .hlist dt li:last-child::after,.mw-parser-output .hlist li dd:last-child::after,.mw-parser-output .hlist li dt:last-child::after,.mw-parser-output .hlist li li:last-child::after{content:")";font-weight:normal}.mw-parser-output .hlist ol{counter-reset:listitem}.mw-parser-output .hlist ol>li{counter-increment:listitem}.mw-parser-output .hlist ol>li::before{content:" "counter(listitem)"\a0 "}.mw-parser-output .hlist dd ol>li:first-child::before,.mw-parser-output .hlist dt ol>li:first-child::before,.mw-parser-output .hlist li ol>li:first-child::before{content:" ("counter(listitem)"\a0 "}</style></div><div role="navigation" class="navbox" aria-label="Navbox" style="width:100%; margin:0.5em 0 0.5em 0;;padding:3px"><table class="nowraplinks navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background: #EAECF0;color:black;">Classification</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><div style="position:relative; float:right; font-size:0.8em;"><a href="https://www.wikidata.org/wiki/Q4682249" class="extiw" title="d:Q4682249">D</a></div><div class="hlist" style="text-align:left;"><ul><li><b><a href="/wiki/International_Classification_of_Diseases_for_Oncology" title="International Classification of Diseases for Oncology">ICD-O</a></b>: 8932/0</li><li><b><a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">MeSH</a></b>: <a rel="nofollow" class="external text" href="https://meshb.nlm.nih.gov/record/ui?ui=D018194">D018194</a></li><li><b><a href="/wiki/SNOMED_CT" title="SNOMED CT">SNOMED CT</a></b>: <a rel="nofollow" class="external text" href="http://snomed.info/id/40293003">40293003</a></li></ul></div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Connective/soft_tissue_tumors_and_sarcomas" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><style data-mw-deduplicate="TemplateStyles:r1239400231">.mw-parser-output .navbar{display:inline;font-size:88%;font-weight:normal}.mw-parser-output .navbar-collapse{float:left;text-align:left}.mw-parser-output .navbar-boxtext{word-spacing:0}.mw-parser-output .navbar ul{display:inline-block;white-space:nowrap;line-height:inherit}.mw-parser-output .navbar-brackets::before{margin-right:-0.125em;content:"[ "}.mw-parser-output .navbar-brackets::after{margin-left:-0.125em;content:" ]"}.mw-parser-output .navbar li{word-spacing:-0.125em}.mw-parser-output .navbar a>span,.mw-parser-output .navbar a>abbr{text-decoration:inherit}.mw-parser-output .navbar-mini abbr{font-variant:small-caps;border-bottom:none;text-decoration:none;cursor:inherit}.mw-parser-output .navbar-ct-full{font-size:114%;margin:0 7em}.mw-parser-output .navbar-ct-mini{font-size:114%;margin:0 4em}html.skin-theme-clientpref-night .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}@media(prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}}@media print{.mw-parser-output .navbar{display:none!important}}</style><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Soft_tissue_tumors_and_sarcomas" title="Template:Soft tissue tumors and sarcomas"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Soft_tissue_tumors_and_sarcomas" title="Template talk:Soft tissue tumors and sarcomas"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Soft_tissue_tumors_and_sarcomas" title="Special:EditPage/Template:Soft tissue tumors and sarcomas"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Connective/soft_tissue_tumors_and_sarcomas" style="font-size:114%;margin:0 4em"><a href="/wiki/Connective_tissue" title="Connective tissue">Connective</a>/<a href="/wiki/Soft_tissue" title="Soft tissue">soft tissue</a> <a href="/wiki/Neoplasm" title="Neoplasm">tumors</a> and <a href="/wiki/Sarcoma" title="Sarcoma">sarcomas</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">Not otherwise specified</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Soft-tissue_sarcoma" title="Soft-tissue sarcoma">Soft-tissue sarcoma</a></li> <li><a href="/wiki/Desmoplastic_small-round-cell_tumor" title="Desmoplastic small-round-cell tumor">Desmoplastic small-round-cell tumor</a></li> <li><a href="/wiki/Skin_sarcoma" title="Skin sarcoma">Skin sarcoma</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Connective_tissue_neoplasm" title="Connective tissue neoplasm">Connective tissue neoplasm</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Fibrous_tissue_neoplasm" title="Fibrous tissue neoplasm">Fibromatous</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Fibroma" title="Fibroma">Fibroma</a>/<a href="/wiki/Fibrosarcoma" title="Fibrosarcoma">fibrosarcoma</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Dermatofibrosarcoma_protuberans" title="Dermatofibrosarcoma protuberans">Dermatofibrosarcoma protuberans</a></li> <li><a href="/wiki/Desmoplastic_fibroma" title="Desmoplastic fibroma">Desmoplastic fibroma</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Fibroma" title="Fibroma">Fibroma</a>/<a href="/wiki/Fibromatosis" title="Fibromatosis">fibromatosis</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Aggressive_fibromatosis" title="Aggressive fibromatosis">Aggressive fibromatosis</a></li> <li><a href="/wiki/Aggressive_infantile_fibromatosis" class="mw-redirect" title="Aggressive infantile fibromatosis">Aggressive infantile fibromatosis</a></li> <li><a href="/wiki/Aponeurotic_fibroma" title="Aponeurotic fibroma">Aponeurotic fibroma</a></li> <li><a href="/wiki/Collagenous_fibroma" title="Collagenous fibroma">Collagenous fibroma</a></li> <li><a href="/wiki/Diffuse_infantile_fibromatosis" title="Diffuse infantile fibromatosis">Diffuse infantile fibromatosis</a></li> <li>Familial myxovascular fibromas</li> <li><a href="/wiki/Fibroma_of_tendon_sheath" title="Fibroma of tendon sheath">Fibroma of tendon sheath</a></li> <li><a href="/wiki/Fibromatosis_colli" title="Fibromatosis colli">Fibromatosis colli</a></li> <li><a href="/wiki/Infantile_digital_fibromatosis" title="Infantile digital fibromatosis">Infantile digital fibromatosis</a></li> <li><a href="/wiki/Juvenile_hyaline_fibromatosis" title="Juvenile hyaline fibromatosis">Juvenile hyaline fibromatosis</a></li> <li><a href="/wiki/Plantar_fibromatosis" title="Plantar fibromatosis">Plantar fibromatosis</a></li> <li><a href="/wiki/Pleomorphic_fibroma" title="Pleomorphic fibroma">Pleomorphic fibroma</a></li> <li><a href="/wiki/Oral_submucous_fibrosis" title="Oral submucous fibrosis">Oral submucous fibrosis</a></li> <li><a href="/wiki/Pachydermodactyly" title="Pachydermodactyly">Pachydermodactyly</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Histiocytoma" title="Histiocytoma">Histiocytoma</a>/<a href="/wiki/Histiocytic_sarcoma" title="Histiocytic sarcoma">histiocytic sarcoma</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Benign_fibrous_histiocytoma" class="mw-redirect" title="Benign fibrous histiocytoma">Benign fibrous histiocytoma</a></li> <li><a href="/wiki/Pleomorphic_undifferentiated_sarcoma" class="mw-redirect" title="Pleomorphic undifferentiated sarcoma">Malignant fibrous histiocytoma</a></li> <li><a href="/wiki/Atypical_fibroxanthoma" title="Atypical fibroxanthoma">Atypical fibroxanthoma</a></li> <li><a href="/wiki/Solitary_fibrous_tumor" title="Solitary fibrous tumor">Solitary fibrous tumor</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Myxoma" title="Myxoma">Myxomatous</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Myxoma" title="Myxoma">Myxoma</a>/<a href="/wiki/Myxosarcoma" title="Myxosarcoma">myxosarcoma</a> <ul><li><a href="/wiki/Cutaneous_myxoma" title="Cutaneous myxoma">Cutaneous myxoma</a></li> <li><a href="/wiki/Superficial_acral_fibromyxoma" title="Superficial acral fibromyxoma">Superficial acral fibromyxoma</a></li></ul></li> <li><a href="/wiki/Aggressive_angiomyxoma" title="Aggressive angiomyxoma">Angiomyxoma</a></li> <li><a href="/wiki/Ossifying_fibromyxoid_tumour" title="Ossifying fibromyxoid tumour">Ossifying fibromyxoid tumour</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Fibroepithelial_neoplasms" class="mw-redirect" title="Fibroepithelial neoplasms">Fibroepithelial</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Brenner_tumour" title="Brenner tumour">Brenner tumour</a></li> <li><a href="/wiki/Fibroadenoma" title="Fibroadenoma">Fibroadenoma</a></li> <li><a href="/wiki/Phyllodes_tumor" title="Phyllodes tumor">Phyllodes tumor</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Synovial_joint" title="Synovial joint">Synovial</a>-like</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Synovial_sarcoma" title="Synovial sarcoma">Synovial sarcoma</a></li> <li><a href="/wiki/Clear-cell_sarcoma" class="mw-redirect" title="Clear-cell sarcoma">Clear-cell sarcoma</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Adipose_tissue_neoplasm" title="Adipose tissue neoplasm">Lipomatous</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Lipoma" title="Lipoma">Lipoma</a>/<a href="/wiki/Liposarcoma" title="Liposarcoma">liposarcoma</a> <ul><li><a href="/wiki/Myelolipoma" title="Myelolipoma">Myelolipoma</a></li> <li><a href="/wiki/Myxoid_liposarcoma" title="Myxoid liposarcoma">Myxoid liposarcoma</a></li></ul></li> <li><a href="/wiki/Perivascular_epithelioid_cell_tumour" title="Perivascular epithelioid cell tumour">PEComa</a> <ul><li><a href="/wiki/Angiomyolipoma" title="Angiomyolipoma">Angiomyolipoma</a></li></ul></li></ul> <ul><li><a href="/wiki/Chondroid_lipoma" title="Chondroid lipoma">Chondroid lipoma</a></li> <li><a href="/wiki/Intradermal_spindle_cell_lipoma" class="mw-redirect" title="Intradermal spindle cell lipoma">Intradermal spindle cell lipoma</a></li> <li><a href="/wiki/Pleomorphic_lipoma" title="Pleomorphic lipoma">Pleomorphic lipoma</a></li> <li><a href="/wiki/Lipoblastomatosis" title="Lipoblastomatosis">Lipoblastomatosis</a></li> <li><a href="/wiki/Spindle_cell_lipoma" title="Spindle cell lipoma">Spindle cell lipoma</a></li> <li><a href="/wiki/Hibernoma" title="Hibernoma">Hibernoma</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Muscle_tissue_neoplasm" class="mw-redirect" title="Muscle tissue neoplasm">Myomatous</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">General</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Myoma" title="Myoma">Myoma</a>/<a href="/wiki/Myosarcoma" title="Myosarcoma">myosarcoma</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><a href="/wiki/Smooth_muscle_tissue" class="mw-redirect" title="Smooth muscle tissue">Smooth muscle</a></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Leiomyoma" title="Leiomyoma">Leiomyoma</a>/<a href="/wiki/Leiomyosarcoma" title="Leiomyosarcoma">leiomyosarcoma</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><a href="/wiki/Skeletal_muscle" title="Skeletal muscle">Skeletal muscle</a></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Rhabdomyoma" title="Rhabdomyoma">Rhabdomyoma</a>/<a href="/wiki/Rhabdomyosarcoma" title="Rhabdomyosarcoma">rhabdomyosarcoma</a>: <a href="/wiki/Embryonal_rhabdomyosarcoma" title="Embryonal rhabdomyosarcoma">Embryonal rhabdomyosarcoma</a> <ul><li><a href="/wiki/Sarcoma_botryoides" title="Sarcoma botryoides">Sarcoma botryoides</a></li></ul></li> <li><a href="/wiki/Alveolar_rhabdomyosarcoma" title="Alveolar rhabdomyosarcoma">Alveolar rhabdomyosarcoma</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Leiomyoma" title="Leiomyoma">Leiomyoma</a> <ul><li><a href="/wiki/Cutaneous_leiomyoma" title="Cutaneous leiomyoma">Cutaneous</a></li></ul></li> <li><a href="/wiki/Angioleiomyoma" title="Angioleiomyoma">Angioleiomyoma</a></li> <li><a href="/wiki/Angiolipoleiomyoma" title="Angiolipoleiomyoma">Angiolipoleiomyoma</a></li> <li><a href="/wiki/Genital_leiomyoma" title="Genital leiomyoma">Genital leiomyoma</a></li> <li><a href="/wiki/Leiomyosarcoma" title="Leiomyosarcoma">Leiomyosarcoma</a></li> <li><a href="/wiki/Hereditary_leiomyomatosis_and_renal_cell_cancer_syndrome" title="Hereditary leiomyomatosis and renal cell cancer syndrome">Multiple cutaneous and uterine leiomyomatosis syndrome</a></li> <li><a href="/wiki/Multiple_cutaneous_leiomyoma" class="mw-redirect" title="Multiple cutaneous leiomyoma">Multiple cutaneous leiomyoma</a></li> <li><a href="/wiki/Neural_fibrolipoma" title="Neural fibrolipoma">Neural fibrolipoma</a></li> <li><a href="/wiki/Solitary_cutaneous_leiomyoma" class="mw-redirect" title="Solitary cutaneous leiomyoma">Solitary cutaneous leiomyoma</a></li> <li><a href="/wiki/Smooth_muscle_tumor_of_uncertain_malignant_potential" title="Smooth muscle tumor of uncertain malignant potential">STUMP</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Complex_and_mixed_tumor" class="mw-redirect" title="Complex and mixed tumor">Complex mixed and stromal</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a class="mw-selflink selflink">Adenomyoma</a></li> <li><a href="/wiki/Pleomorphic_adenoma" title="Pleomorphic adenoma">Pleomorphic adenoma</a></li> <li><a href="/wiki/Mixed_M%C3%BCllerian_tumor" title="Mixed Müllerian tumor">Mixed Müllerian tumor</a></li> <li><a href="/wiki/Mesoblastic_nephroma" title="Mesoblastic nephroma">Mesoblastic nephroma</a></li> <li><a href="/wiki/Wilms%27_tumor" title="Wilms' tumor">Wilms' tumor</a></li> <li><a href="/wiki/Malignant_rhabdoid_tumour" title="Malignant rhabdoid tumour">Malignant rhabdoid tumour</a></li> <li><a href="/wiki/Clear-cell_sarcoma_of_the_kidney" title="Clear-cell sarcoma of the kidney">Clear-cell sarcoma of the kidney</a></li> <li><a href="/wiki/Hepatoblastoma" title="Hepatoblastoma">Hepatoblastoma</a></li> <li><a href="/wiki/Pancreatoblastoma" title="Pancreatoblastoma">Pancreatoblastoma</a></li> <li><a href="/wiki/Carcinosarcoma" title="Carcinosarcoma">Carcinosarcoma</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Mesothelium" title="Mesothelium">Mesothelial</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Mesothelioma" title="Mesothelioma">Mesothelioma</a></li> <li><a href="/wiki/Adenomatoid_tumor" title="Adenomatoid tumor">Adenomatoid tumor</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Tumors_of_the_female_urogenital_system" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Female_genital_neoplasia" title="Template:Female genital neoplasia"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Female_genital_neoplasia" title="Template talk:Female genital neoplasia"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Female_genital_neoplasia" title="Special:EditPage/Template:Female genital neoplasia"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Tumors_of_the_female_urogenital_system" style="font-size:114%;margin:0 4em"><a href="/wiki/Tumor" class="mw-redirect" title="Tumor">Tumors</a> of the female <a href="/wiki/Urogenital_system" class="mw-redirect" title="Urogenital system">urogenital system</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Adnexa_of_uterus" class="mw-redirect" title="Adnexa of uterus">Adnexa</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Ovarian_cancer" title="Ovarian cancer">Ovaries</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/w/index.php?title=Glandular_and_epithelial_neoplasm&action=edit&redlink=1" class="new" title="Glandular and epithelial neoplasm (page does not exist)">Glandular and epithelial</a>/<br /><a href="/wiki/Surface_epithelial-stromal_tumor" title="Surface epithelial-stromal tumor">surface epithelial-<br />stromal tumor</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="CMS:" scope="row" class="navbox-group" style="width:1%">CMS:</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Ovarian_serous_cystadenoma" title="Ovarian serous cystadenoma">Ovarian serous cystadenoma</a></li> <li><a href="/wiki/Mucinous_cystadenoma" title="Mucinous cystadenoma">Mucinous cystadenoma</a></li> <li><a href="/wiki/Cystadenocarcinoma" title="Cystadenocarcinoma">Cystadenocarcinoma</a> <ul><li><a href="/wiki/Papillary_serous_cystadenocarcinoma" title="Papillary serous cystadenocarcinoma">Papillary serous cystadenocarcinoma</a></li></ul></li> <li><a href="/wiki/Krukenberg_tumor" title="Krukenberg tumor">Krukenberg tumor</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Endometrioid_tumor" title="Endometrioid tumor">Endometrioid tumor</a></li> <li><a href="/wiki/Ovarian_clear-cell_carcinoma" title="Ovarian clear-cell carcinoma">Ovarian clear-cell carcinoma</a></li> <li><a href="/wiki/Brenner_tumour" title="Brenner tumour">Brenner tumour</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Sex_cord%E2%80%93gonadal_stromal_tumour" title="Sex cord–gonadal stromal tumour">Sex cord–gonadal stromal</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Leydig_cell_tumour" title="Leydig cell tumour">Leydig cell tumour</a></li> <li><a href="/wiki/Sertoli_cell_tumour" title="Sertoli cell tumour">Sertoli cell tumour</a></li> <li><a href="/wiki/Sertoli%E2%80%93Leydig_cell_tumour" title="Sertoli–Leydig cell tumour">Sertoli–Leydig cell tumour</a></li> <li><a href="/wiki/Thecoma" title="Thecoma">Thecoma</a></li> <li><a href="/wiki/Granulosa_cell_tumour" title="Granulosa cell tumour">Granulosa cell tumour</a></li> <li><a href="/wiki/Luteoma" title="Luteoma">Luteoma</a></li> <li><a href="/wiki/Sex_cord_tumour_with_annular_tubules" title="Sex cord tumour with annular tubules">Sex cord tumour with annular tubules</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Germ_cell_tumor" title="Germ cell tumor">Germ cell</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Dysgerminoma" title="Dysgerminoma">Dysgerminoma</a></li> <li><a href="/wiki/Germ_cell_tumor#Nongerminomatous" title="Germ cell tumor">Nongerminomatous</a> <ul><li><a href="/wiki/Embryonal_carcinoma" title="Embryonal carcinoma">Embryonal carcinoma</a></li> <li><a href="/wiki/Endodermal_sinus_tumor" title="Endodermal sinus tumor">Endodermal sinus tumor</a></li> <li><a href="/wiki/Gonadoblastoma" title="Gonadoblastoma">Gonadoblastoma</a></li> <li><a href="/wiki/Teratoma" title="Teratoma">Teratoma</a>/<a href="/wiki/Struma_ovarii" title="Struma ovarii">Struma ovarii</a></li> <li><a href="/wiki/Choriocarcinoma" title="Choriocarcinoma">Choriocarcinoma</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Ovarian_fibroma" title="Ovarian fibroma">Fibroma</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Meigs%27_syndrome" class="mw-redirect" title="Meigs' syndrome">Meigs' syndrome</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Fallopian_tube_cancer" title="Fallopian tube cancer">Fallopian tube</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Adenomatoid_tumor" title="Adenomatoid tumor">Adenomatoid tumor</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Uterine_cancer" title="Uterine cancer">Uterus</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Myometrium" title="Myometrium">Myometrium</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Uterine_fibroid" title="Uterine fibroid">Uterine fibroids/leiomyoma</a></li> <li><a href="/wiki/Leiomyosarcoma" title="Leiomyosarcoma">Leiomyosarcoma</a></li> <li><a class="mw-selflink selflink">Adenomyoma</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Endometrial_cancer" title="Endometrial cancer">Endometrium</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Endometrioid_tumor" title="Endometrioid tumor">Endometrioid tumor</a></li> <li><a href="/wiki/Uterine_serous_carcinoma" title="Uterine serous carcinoma">Uterine papillary serous carcinoma</a></li> <li><a href="/wiki/Endometrial_intraepithelial_neoplasia" title="Endometrial intraepithelial neoplasia">Endometrial intraepithelial neoplasia</a></li> <li><a href="/wiki/Uterine_clear-cell_carcinoma" title="Uterine clear-cell carcinoma">Uterine clear-cell carcinoma</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Cervical_cancer" title="Cervical cancer">Cervix</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cervical_intraepithelial_neoplasia" title="Cervical intraepithelial neoplasia">Cervical intraepithelial neoplasia</a></li> <li><a href="/wiki/Clear-cell_adenocarcinoma_of_the_vagina" title="Clear-cell adenocarcinoma of the vagina">Clear-cell carcinoma</a></li> <li><a href="/wiki/Squamous-cell_carcinoma#Vagina_and_cervix" title="Squamous-cell carcinoma">SCC</a></li> <li><a href="/wiki/Glassy_cell_carcinoma_of_the_cervix" title="Glassy cell carcinoma of the cervix">Glassy-cell carcinoma</a></li> <li><a href="/wiki/Villoglandular_adenocarcinoma_of_the_cervix" title="Villoglandular adenocarcinoma of the cervix">Villoglandular adenocarcinoma</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Placenta" title="Placenta">Placenta</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Choriocarcinoma" title="Choriocarcinoma">Choriocarcinoma</a></li> <li><a href="/wiki/Gestational_trophoblastic_disease" title="Gestational trophoblastic disease">Gestational trophoblastic disease</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">General</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Uterine_sarcoma" title="Uterine sarcoma">Uterine sarcoma</a></li> <li><a href="/wiki/Mixed_M%C3%BCllerian_tumor" title="Mixed Müllerian tumor">Mixed Müllerian tumor</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Vaginal_cancer" title="Vaginal cancer">Vagina</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Squamous-cell_carcinoma_of_the_vagina" class="mw-redirect" title="Squamous-cell carcinoma of the vagina">Squamous-cell carcinoma of the vagina</a></li> <li><a href="/wiki/Sarcoma_botryoides" title="Sarcoma botryoides">Botryoid rhabdomyosarcoma</a></li> <li><a href="/wiki/Clear-cell_adenocarcinoma_of_the_vagina" title="Clear-cell adenocarcinoma of the vagina">Clear-cell adenocarcinoma of the vagina</a></li> <li><a href="/wiki/Vaginal_intraepithelial_neoplasia" title="Vaginal intraepithelial neoplasia">Vaginal intraepithelial neoplasia</a></li> <li><a href="/wiki/Vaginal_cysts" title="Vaginal cysts">Vaginal cysts</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Vulvar_cancer" title="Vulvar cancer">Vulva</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Squamous_cell_carcinoma" class="mw-redirect" title="Squamous cell carcinoma">SCC</a></li> <li><a href="/wiki/Melanoma" title="Melanoma">Melanoma</a></li> <li><a href="/wiki/Papillary_hidradenoma" title="Papillary hidradenoma">Papillary hidradenoma</a></li> <li><a href="/wiki/Extramammary_Paget%27s_disease" title="Extramammary Paget's disease">Extramammary Paget's disease</a></li> <li><a href="/wiki/Vulvar_intraepithelial_neoplasia" title="Vulvar intraepithelial neoplasia">Vulvar intraepithelial neoplasia</a></li> <li><a href="/wiki/Bartholin_gland_carcinoma" title="Bartholin gland carcinoma">Bartholin gland carcinoma</a></li></ul> </div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Retrieved from "<a dir="ltr" href="https://en.wikipedia.org/w/index.php?title=Adenomyoma&oldid=1174777391">https://en.wikipedia.org/w/index.php?title=Adenomyoma&oldid=1174777391</a>"</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Help:Category" title="Help:Category">Category</a>: <ul><li><a href="/wiki/Category:Gynaecological_neoplasia" title="Category:Gynaecological neoplasia">Gynaecological neoplasia</a></li></ul></div><div id="mw-hidden-catlinks" class="mw-hidden-catlinks mw-hidden-cats-hidden">Hidden categories: <ul><li><a href="/wiki/Category:Articles_with_short_description" title="Category:Articles with short description">Articles with short description</a></li><li><a href="/wiki/Category:Short_description_is_different_from_Wikidata" title="Category:Short description is different from Wikidata">Short description is different from Wikidata</a></li></ul></div></div> </div> </main> </div> <div class="mw-footer-container"> <footer id="footer" class="mw-footer" > <ul id="footer-info"> <li id="footer-info-lastmod"> This page was last edited on 10 September 2023, at 16:26<span class="anonymous-show"> (UTC)</span>.</li> <li id="footer-info-copyright">Text is available under the <a 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