In situ forming biodegradable electroactive hydrogels - Polymer Chemistry (RSC Publishing)

<!DOCTYPE html>   <html lang="en">  <head id="Head1"> <title> In situ forming biodegradable electroactive hydrogels - Polymer Chemistry (RSC Publishing) </title> <meta charset="utf-8"> <meta http-equiv="X-UA-Compatible" content="IE=edge"><script type="text/javascript">window.NREUM||(NREUM={});NREUM.info = {"beacon":"bam.nr-data.net","errorBeacon":"bam.nr-data.net","licenseKey":"NRJS-aaa897feae8feeca979","applicationID":"1313546638","transactionName":"M1wANxQFCEcDVU0PWgoWLzUlSyVbDEJcCEEnVgwXFAsKWAdEFgdHEFABDwMIB1oGX1cB","queueTime":0,"applicationTime":144,"agent":"","atts":""}</script><script type="text/javascript">(window.NREUM||(NREUM={})).init={privacy:{cookies_enabled:true},ajax:{deny_list:["bam.nr-data.net"]},distributed_tracing:{enabled:true}};(window.NREUM||(NREUM={})).loader_config={agentID:"1386013924",accountID:"2851366",trustKey:"1029994",xpid:"Vg4CUFVVDhABV1BRAgUBUFcJ",licenseKey:"NRJS-aaa897feae8feeca979",applicationID:"1313546638"};;/*! For license information please see nr-loader-spa-1.274.0.min.js.LICENSE.txt */ (()=>{var e,t,r={8122:(e,t,r)=>{"use strict";r.d(t,{a:()=>i});var n=r(944);function i(e,t){try{if(!e||"object"!=typeof e)return(0,n.R)(3);if(!t||"object"!=typeof t)return(0,n.R)(4);const r=Object.create(Object.getPrototypeOf(t),Object.getOwnPropertyDescriptors(t)),o=0===Object.keys(r).length?e:r;for(let a in o)if(void 0!==e[a])try{if(null===e[a]){r[a]=null;continue}Array.isArray(e[a])&&Array.isArray(t[a])?r[a]=Array.from(new Set([...e[a],...t[a]])):"object"==typeof e[a]&&"object"==typeof t[a]?r[a]=i(e[a],t[a]):r[a]=e[a]}catch(e){(0,n.R)(1,e)}return r}catch(e){(0,n.R)(2,e)}}},2555:(e,t,r)=>{"use strict";r.d(t,{Vp:()=>c,fn:()=>s,x1:()=>u});var n=r(384),i=r(8122);const o={beacon:n.NT.beacon,errorBeacon:n.NT.errorBeacon,licenseKey:void 0,applicationID:void 0,sa:void 0,queueTime:void 0,applicationTime:void 0,ttGuid:void 0,user:void 0,account:void 0,product:void 0,extra:void 0,jsAttributes:{},userAttributes:void 0,atts:void 0,transactionName:void 0,tNamePlain:void 0},a={};function s(e){try{const t=c(e);return!!t.licenseKey&&!!t.errorBeacon&&!!t.applicationID}catch(e){return!1}}function c(e){if(!e)throw new Error("All info objects require an agent identifier!");if(!a[e])throw new Error("Info for ".concat(e," was never set"));return a[e]}function u(e,t){if(!e)throw new Error("All info objects require an agent identifier!");a[e]=(0,i.a)(t,o);const r=(0,n.nY)(e);r&&(r.info=a[e])}},9417:(e,t,r)=>{"use strict";r.d(t,{D0:()=>h,gD:()=>g,xN:()=>p});var n=r(993);const i=e=>{if(!e||"string"!=typeof e)return!1;try{document.createDocumentFragment().querySelector(e)}catch{return!1}return!0};var o=r(2614),a=r(944),s=r(384),c=r(8122);const u="[data-nr-mask]",d=()=>{const e={mask_selector:"*",block_selector:"[data-nr-block]",mask_input_options:{color:!1,date:!1,"datetime-local":!1,email:!1,month:!1,number:!1,range:!1,search:!1,tel:!1,text:!1,time:!1,url:!1,week:!1,textarea:!1,select:!1,password:!0}};return{ajax:{deny_list:void 0,block_internal:!0,enabled:!0,harvestTimeSeconds:10,autoStart:!0},distributed_tracing:{enabled:void 0,exclude_newrelic_header:void 0,cors_use_newrelic_header:void 0,cors_use_tracecontext_headers:void 0,allowed_origins:void 0},feature_flags:[],generic_events:{enabled:!0,harvestTimeSeconds:30,autoStart:!0},harvest:{tooManyRequestsDelay:60},jserrors:{enabled:!0,harvestTimeSeconds:10,autoStart:!0},logging:{enabled:!0,harvestTimeSeconds:10,autoStart:!0,level:n.p_.INFO},metrics:{enabled:!0,autoStart:!0},obfuscate:void 0,page_action:{enabled:!0},page_view_event:{enabled:!0,autoStart:!0},page_view_timing:{enabled:!0,harvestTimeSeconds:30,autoStart:!0},performance:{capture_marks:!1,capture_measures:!1},privacy:{cookies_enabled:!0},proxy:{assets:void 0,beacon:void 0},session:{expiresMs:o.wk,inactiveMs:o.BB},session_replay:{autoStart:!0,enabled:!1,harvestTimeSeconds:60,preload:!1,sampling_rate:10,error_sampling_rate:100,collect_fonts:!1,inline_images:!1,fix_stylesheets:!0,mask_all_inputs:!0,get mask_text_selector(){return e.mask_selector},set mask_text_selector(t){i(t)?e.mask_selector="".concat(t,",").concat(u):""===t||null===t?e.mask_selector=u:(0,a.R)(5,t)},get block_class(){return"nr-block"},get ignore_class(){return"nr-ignore"},get mask_text_class(){return"nr-mask"},get block_selector(){return e.block_selector},set block_selector(t){i(t)?e.block_selector+=",".concat(t):""!==t&&(0,a.R)(6,t)},get mask_input_options(){return e.mask_input_options},set mask_input_options(t){t&&"object"==typeof t?e.mask_input_options={...t,password:!0}:(0,a.R)(7,t)}},session_trace:{enabled:!0,harvestTimeSeconds:10,autoStart:!0},soft_navigations:{enabled:!0,harvestTimeSeconds:10,autoStart:!0},spa:{enabled:!0,harvestTimeSeconds:10,autoStart:!0},ssl:void 0,user_actions:{enabled:!0}}},l={},f="All configuration objects require an agent identifier!";function h(e){if(!e)throw new Error(f);if(!l[e])throw new Error("Configuration for ".concat(e," was never set"));return l[e]}function p(e,t){if(!e)throw new Error(f);l[e]=(0,c.a)(t,d());const r=(0,s.nY)(e);r&&(r.init=l[e])}function g(e,t){if(!e)throw new Error(f);var r=h(e);if(r){for(var n=t.split("."),i=0;i<n.length-1;i++)if("object"!=typeof(r=r[n[i]]))return;r=r[n[n.length-1]]}return r}},5603:(e,t,r)=>{"use strict";r.d(t,{a:()=>c,o:()=>s});var n=r(384),i=r(8122);const o={accountID:void 0,trustKey:void 0,agentID:void 0,licenseKey:void 0,applicationID:void 0,xpid:void 0},a={};function s(e){if(!e)throw new Error("All loader-config objects require an agent identifier!");if(!a[e])throw new Error("LoaderConfig for ".concat(e," was never set"));return a[e]}function c(e,t){if(!e)throw new Error("All loader-config objects require an agent identifier!");a[e]=(0,i.a)(t,o);const r=(0,n.nY)(e);r&&(r.loader_config=a[e])}},3371:(e,t,r)=>{"use strict";r.d(t,{V:()=>f,f:()=>l});var n=r(8122),i=r(384),o=r(6154),a=r(9324);let s=0;const c={buildEnv:a.F3,distMethod:a.Xs,version:a.xv,originTime:o.WN},u={customTransaction:void 0,disabled:!1,isolatedBacklog:!1,loaderType:void 0,maxBytes:3e4,onerror:void 0,ptid:void 0,releaseIds:{},appMetadata:{},session:void 0,denyList:void 0,timeKeeper:void 0,obfuscator:void 0},d={};function l(e){if(!e)throw new Error("All runtime objects require an agent identifier!");if(!d[e])throw new Error("Runtime for ".concat(e," was never set"));return d[e]}function f(e,t){if(!e)throw new Error("All runtime objects require an agent identifier!");d[e]={...(0,n.a)(t,u),...c},Object.hasOwnProperty.call(d[e],"harvestCount")||Object.defineProperty(d[e],"harvestCount",{get:()=>++s});const r=(0,i.nY)(e);r&&(r.runtime=d[e])}},9324:(e,t,r)=>{"use strict";r.d(t,{F3:()=>i,Xs:()=>o,Yq:()=>a,xv:()=>n});const n="1.274.0",i="PROD",o="CDN",a="^2.0.0-alpha.17"},6154:(e,t,r)=>{"use strict";r.d(t,{A4:()=>s,OF:()=>d,RI:()=>i,WN:()=>h,bv:()=>o,gm:()=>a,lR:()=>f,m:()=>u,mw:()=>c,sb:()=>l});var n=r(1863);const i="undefined"!=typeof window&&!!window.document,o="undefined"!=typeof WorkerGlobalScope&&("undefined"!=typeof self&&self instanceof WorkerGlobalScope&&self.navigator instanceof WorkerNavigator||"undefined"!=typeof globalThis&&globalThis instanceof WorkerGlobalScope&&globalThis.navigator instanceof WorkerNavigator),a=i?window:"undefined"!=typeof WorkerGlobalScope&&("undefined"!=typeof self&&self instanceof WorkerGlobalScope&&self||"undefined"!=typeof globalThis&&globalThis instanceof WorkerGlobalScope&&globalThis),s="complete"===a?.document?.readyState,c=Boolean("hidden"===a?.document?.visibilityState),u=""+a?.location,d=/iPad|iPhone|iPod/.test(a.navigator?.userAgent),l=d&&"undefined"==typeof SharedWorker,f=(()=>{const e=a.navigator?.userAgent?.match(/Firefox[/\s](\d+\.\d+)/);return Array.isArray(e)&&e.length>=2?+e[1]:0})(),h=Date.now()-(0,n.t)()},7295:(e,t,r)=>{"use strict";r.d(t,{Xv:()=>a,gX:()=>i,iW:()=>o});var n=[];function i(e){if(!e||o(e))return!1;if(0===n.length)return!0;for(var t=0;t<n.length;t++){var r=n[t];if("*"===r.hostname)return!1;if(s(r.hostname,e.hostname)&&c(r.pathname,e.pathname))return!1}return!0}function o(e){return void 0===e.hostname}function a(e){if(n=[],e&&e.length)for(var t=0;t<e.length;t++){let r=e[t];if(!r)continue;0===r.indexOf("http://")?r=r.substring(7):0===r.indexOf("https://")&&(r=r.substring(8));const i=r.indexOf("/");let o,a;i>0?(o=r.substring(0,i),a=r.substring(i)):(o=r,a="");let[s]=o.split(":");n.push({hostname:s,pathname:a})}}function s(e,t){return!(e.length>t.length)&&t.indexOf(e)===t.length-e.length}function c(e,t){return 0===e.indexOf("/")&&(e=e.substring(1)),0===t.indexOf("/")&&(t=t.substring(1)),""===e||e===t}},1687:(e,t,r)=>{"use strict";r.d(t,{Ak:()=>c,Ze:()=>l,x3:()=>u});var n=r(7836),i=r(3606),o=r(860),a=r(2646);const s={};function c(e,t){const r={staged:!1,priority:o.P3[t]||0};d(e),s[e].get(t)||s[e].set(t,r)}function u(e,t){e&&s[e]&&(s[e].get(t)&&s[e].delete(t),h(e,t,!1),s[e].size&&f(e))}function d(e){if(!e)throw new Error("agentIdentifier required");s[e]||(s[e]=new Map)}function l(e="",t="feature",r=!1){if(d(e),!e||!s[e].get(t)||r)return h(e,t);s[e].get(t).staged=!0,f(e)}function f(e){const t=Array.from(s[e]);t.every((([e,t])=>t.staged))&&(t.sort(((e,t)=>e[1].priority-t[1].priority)),t.forEach((([t])=>{s[e].delete(t),h(e,t)})))}function h(e,t,r=!0){const o=e?n.ee.get(e):n.ee,s=i.i.handlers;if(!o.aborted&&o.backlog&&s){if(r){const e=o.backlog[t],r=s[t];if(r){for(let t=0;e&&t<e.length;++t)p(e[t],r);Object.entries(r).forEach((([e,t])=>{Object.values(t||{}).forEach((t=>{t[0]?.on&&t[0]?.context()instanceof a.y&&t[0].on(e,t[1])}))}))}}o.isolatedBacklog||delete s[t],o.backlog[t]=null,o.emit("drain-"+t,[])}}function p(e,t){var r=e[1];Object.values(t[r]||{}).forEach((t=>{var r=e[0];if(t[0]===r){var n=t[1],i=e[3],o=e[2];n.apply(i,o)}}))}},7836:(e,t,r)=>{"use strict";r.d(t,{P:()=>c,ee:()=>u});var n=r(384),i=r(8990),o=r(3371),a=r(2646),s=r(5607);const c="nr@context:".concat(s.W),u=function e(t,r){var n={},s={},d={},l=!1;try{l=16===r.length&&(0,o.f)(r).isolatedBacklog}catch(e){}var f={on:p,addEventListener:p,removeEventListener:function(e,t){var r=n[e];if(!r)return;for(var i=0;i<r.length;i++)r[i]===t&&r.splice(i,1)},emit:function(e,r,n,i,o){!1!==o&&(o=!0);if(u.aborted&&!i)return;t&&o&&t.emit(e,r,n);for(var a=h(n),c=g(e),d=c.length,l=0;l<d;l++)c[l].apply(a,r);var p=v()[s[e]];p&&p.push([f,e,r,a]);return a},get:m,listeners:g,context:h,buffer:function(e,t){const r=v();if(t=t||"feature",f.aborted)return;Object.entries(e||{}).forEach((([e,n])=>{s[n]=t,t in r||(r[t]=[])}))},abort:function(){f._aborted=!0,Object.keys(f.backlog).forEach((e=>{delete f.backlog[e]}))},isBuffering:function(e){return!!v()[s[e]]},debugId:r,backlog:l?{}:t&&"object"==typeof t.backlog?t.backlog:{},isolatedBacklog:l};return Object.defineProperty(f,"aborted",{get:()=>{let e=f._aborted||!1;return e||(t&&(e=t.aborted),e)}}),f;function h(e){return e&&e instanceof a.y?e:e?(0,i.I)(e,c,(()=>new a.y(c))):new a.y(c)}function p(e,t){n[e]=g(e).concat(t)}function g(e){return n[e]||[]}function m(t){return d[t]=d[t]||e(f,t)}function v(){return f.backlog}}(void 0,"globalEE"),d=(0,n.Zm)();d.ee||(d.ee=u)},2646:(e,t,r)=>{"use strict";r.d(t,{y:()=>n});class n{constructor(e){this.contextId=e}}},9908:(e,t,r)=>{"use strict";r.d(t,{d:()=>n,p:()=>i});var n=r(7836).ee.get("handle");function i(e,t,r,i,o){o?(o.buffer([e],i),o.emit(e,t,r)):(n.buffer([e],i),n.emit(e,t,r))}},3606:(e,t,r)=>{"use strict";r.d(t,{i:()=>o});var n=r(9908);o.on=a;var i=o.handlers={};function o(e,t,r,o){a(o||n.d,i,e,t,r)}function a(e,t,r,i,o){o||(o="feature"),e||(e=n.d);var a=t[o]=t[o]||{};(a[r]=a[r]||[]).push([e,i])}},3878:(e,t,r)=>{"use strict";function n(e,t){return{capture:e,passive:!1,signal:t}}function i(e,t,r=!1,i){window.addEventListener(e,t,n(r,i))}function o(e,t,r=!1,i){document.addEventListener(e,t,n(r,i))}r.d(t,{DD:()=>o,jT:()=>n,sp:()=>i})},5607:(e,t,r)=>{"use strict";r.d(t,{W:()=>n});const n=(0,r(9566).bz)()},9566:(e,t,r)=>{"use strict";r.d(t,{LA:()=>s,ZF:()=>c,bz:()=>a,el:()=>u});var n=r(6154);const i="xxxxxxxx-xxxx-4xxx-yxxx-xxxxxxxxxxxx";function o(e,t){return e?15&e[t]:16*Math.random()|0}function a(){const e=n.gm?.crypto||n.gm?.msCrypto;let t,r=0;return e&&e.getRandomValues&&(t=e.getRandomValues(new Uint8Array(30))),i.split("").map((e=>"x"===e?o(t,r++).toString(16):"y"===e?(3&o()|8).toString(16):e)).join("")}function s(e){const t=n.gm?.crypto||n.gm?.msCrypto;let r,i=0;t&&t.getRandomValues&&(r=t.getRandomValues(new Uint8Array(e)));const a=[];for(var s=0;s<e;s++)a.push(o(r,i++).toString(16));return a.join("")}function c(){return s(16)}function u(){return s(32)}},2614:(e,t,r)=>{"use strict";r.d(t,{BB:()=>a,H3:()=>n,g:()=>u,iL:()=>c,tS:()=>s,uh:()=>i,wk:()=>o});const n="NRBA",i="SESSION",o=144e5,a=18e5,s={STARTED:"session-started",PAUSE:"session-pause",RESET:"session-reset",RESUME:"session-resume",UPDATE:"session-update"},c={SAME_TAB:"same-tab",CROSS_TAB:"cross-tab"},u={OFF:0,FULL:1,ERROR:2}},1863:(e,t,r)=>{"use strict";function n(){return Math.floor(performance.now())}r.d(t,{t:()=>n})},7485:(e,t,r)=>{"use strict";r.d(t,{D:()=>i});var n=r(6154);function i(e){if(0===(e||"").indexOf("data:"))return{protocol:"data"};try{const t=new URL(e,location.href),r={port:t.port,hostname:t.hostname,pathname:t.pathname,search:t.search,protocol:t.protocol.slice(0,t.protocol.indexOf(":")),sameOrigin:t.protocol===n.gm?.location?.protocol&&t.host===n.gm?.location?.host};return r.port&&""!==r.port||("http:"===t.protocol&&(r.port="80"),"https:"===t.protocol&&(r.port="443")),r.pathname&&""!==r.pathname?r.pathname.startsWith("/")||(r.pathname="/".concat(r.pathname)):r.pathname="/",r}catch(e){return{}}}},944:(e,t,r)=>{"use strict";function n(e,t){"function"==typeof console.debug&&console.debug("New Relic Warning: https://github.com/newrelic/newrelic-browser-agent/blob/main/docs/warning-codes.md#".concat(e),t)}r.d(t,{R:()=>n})},5284:(e,t,r)=>{"use strict";r.d(t,{t:()=>c,B:()=>s});var n=r(7836),i=r(6154);const o="newrelic";const a=new Set,s={};function c(e,t){const r=n.ee.get(t);s[t]??={},e&&"object"==typeof e&&(a.has(t)||(r.emit("rumresp",[e]),s[t]=e,a.add(t),function(e={}){try{i.gm.dispatchEvent(new CustomEvent(o,{detail:e}))}catch(e){}}({loaded:!0})))}},8990:(e,t,r)=>{"use strict";r.d(t,{I:()=>i});var n=Object.prototype.hasOwnProperty;function i(e,t,r){if(n.call(e,t))return e[t];var i=r();if(Object.defineProperty&&Object.keys)try{return Object.defineProperty(e,t,{value:i,writable:!0,enumerable:!1}),i}catch(e){}return e[t]=i,i}},6389:(e,t,r)=>{"use strict";function n(e,t=500,r={}){const n=r?.leading||!1;let i;return(...r)=>{n&&void 0===i&&(e.apply(this,r),i=setTimeout((()=>{i=clearTimeout(i)}),t)),n||(clearTimeout(i),i=setTimeout((()=>{e.apply(this,r)}),t))}}function i(e){let t=!1;return(...r)=>{t||(t=!0,e.apply(this,r))}}r.d(t,{J:()=>i,s:()=>n})},3304:(e,t,r)=>{"use strict";r.d(t,{A:()=>o});var n=r(7836);const i=()=>{const e=new WeakSet;return(t,r)=>{if("object"==typeof r&&null!==r){if(e.has(r))return;e.add(r)}return r}};function o(e){try{return JSON.stringify(e,i())??""}catch(e){try{n.ee.emit("internal-error",[e])}catch(e){}return""}}},5289:(e,t,r)=>{"use strict";r.d(t,{GG:()=>o,sB:()=>a});var n=r(3878);function i(){return"undefined"==typeof document||"complete"===document.readyState}function o(e,t){if(i())return e();(0,n.sp)("load",e,t)}function a(e){if(i())return e();(0,n.DD)("DOMContentLoaded",e)}},384:(e,t,r)=>{"use strict";r.d(t,{NT:()=>o,US:()=>d,Zm:()=>a,bQ:()=>c,dV:()=>s,nY:()=>u,pV:()=>l});var n=r(6154),i=r(1863);const o={beacon:"bam.nr-data.net",errorBeacon:"bam.nr-data.net"};function a(){return n.gm.NREUM||(n.gm.NREUM={}),void 0===n.gm.newrelic&&(n.gm.newrelic=n.gm.NREUM),n.gm.NREUM}function s(){let e=a();return e.o||(e.o={ST:n.gm.setTimeout,SI:n.gm.setImmediate,CT:n.gm.clearTimeout,XHR:n.gm.XMLHttpRequest,REQ:n.gm.Request,EV:n.gm.Event,PR:n.gm.Promise,MO:n.gm.MutationObserver,FETCH:n.gm.fetch,WS:n.gm.WebSocket}),e}function c(e,t){let r=a();r.initializedAgents??={},t.initializedAt={ms:(0,i.t)(),date:new Date},r.initializedAgents[e]=t}function u(e){let t=a();return t.initializedAgents?.[e]}function d(e,t){a()[e]=t}function l(){return function(){let e=a();const t=e.info||{};e.info={beacon:o.beacon,errorBeacon:o.errorBeacon,...t}}(),function(){let e=a();const t=e.init||{};e.init={...t}}(),s(),function(){let e=a();const t=e.loader_config||{};e.loader_config={...t}}(),a()}},2843:(e,t,r)=>{"use strict";r.d(t,{u:()=>i});var n=r(3878);function i(e,t=!1,r,i){(0,n.DD)("visibilitychange",(function(){if(t)return void("hidden"===document.visibilityState&&e());e(document.visibilityState)}),r,i)}},8139:(e,t,r)=>{"use strict";r.d(t,{u:()=>f});var n=r(7836),i=r(3434),o=r(8990),a=r(6154);const s={},c=a.gm.XMLHttpRequest,u="addEventListener",d="removeEventListener",l="nr@wrapped:".concat(n.P);function f(e){var t=function(e){return(e||n.ee).get("events")}(e);if(s[t.debugId]++)return t;s[t.debugId]=1;var r=(0,i.YM)(t,!0);function f(e){r.inPlace(e,[u,d],"-",p)}function p(e,t){return e[1]}return"getPrototypeOf"in Object&&(a.RI&&h(document,f),h(a.gm,f),h(c.prototype,f)),t.on(u+"-start",(function(e,t){var n=e[1];if(null!==n&&("function"==typeof n||"object"==typeof n)){var i=(0,o.I)(n,l,(function(){var e={object:function(){if("function"!=typeof n.handleEvent)return;return n.handleEvent.apply(n,arguments)},function:n}[typeof n];return e?r(e,"fn-",null,e.name||"anonymous"):n}));this.wrapped=e[1]=i}})),t.on(d+"-start",(function(e){e[1]=this.wrapped||e[1]})),t}function h(e,t,...r){let n=e;for(;"object"==typeof n&&!Object.prototype.hasOwnProperty.call(n,u);)n=Object.getPrototypeOf(n);n&&t(n,...r)}},3434:(e,t,r)=>{"use strict";r.d(t,{Jt:()=>o,YM:()=>c});var n=r(7836),i=r(5607);const o="nr@original:".concat(i.W);var a=Object.prototype.hasOwnProperty,s=!1;function c(e,t){return e||(e=n.ee),r.inPlace=function(e,t,n,i,o){n||(n="");const a="-"===n.charAt(0);for(let s=0;s<t.length;s++){const c=t[s],u=e[c];d(u)||(e[c]=r(u,a?c+n:n,i,c,o))}},r.flag=o,r;function r(t,r,n,s,c){return d(t)?t:(r||(r=""),nrWrapper[o]=t,function(e,t,r){if(Object.defineProperty&&Object.keys)try{return Object.keys(e).forEach((function(r){Object.defineProperty(t,r,{get:function(){return e[r]},set:function(t){return e[r]=t,t}})})),t}catch(e){u([e],r)}for(var n in e)a.call(e,n)&&(t[n]=e[n])}(t,nrWrapper,e),nrWrapper);function nrWrapper(){var o,a,d,l;try{a=this,o=[...arguments],d="function"==typeof n?n(o,a):n||{}}catch(t){u([t,"",[o,a,s],d],e)}i(r+"start",[o,a,s],d,c);try{return l=t.apply(a,o)}catch(e){throw i(r+"err",[o,a,e],d,c),e}finally{i(r+"end",[o,a,l],d,c)}}}function i(r,n,i,o){if(!s||t){var a=s;s=!0;try{e.emit(r,n,i,t,o)}catch(t){u([t,r,n,i],e)}s=a}}}function u(e,t){t||(t=n.ee);try{t.emit("internal-error",e)}catch(e){}}function d(e){return!(e&&"function"==typeof e&&e.apply&&!e[o])}},9300:(e,t,r)=>{"use strict";r.d(t,{T:()=>n});const n=r(860).K7.ajax},3333:(e,t,r)=>{"use strict";r.d(t,{TZ:()=>n,Zp:()=>i,mq:()=>s,nf:()=>a,qN:()=>o});const n=r(860).K7.genericEvents,i=["auxclick","click","copy","keydown","paste","scrollend"],o=["focus","blur"],a=4,s=1e3},6774:(e,t,r)=>{"use strict";r.d(t,{T:()=>n});const n=r(860).K7.jserrors},993:(e,t,r)=>{"use strict";r.d(t,{ET:()=>o,TZ:()=>a,p_:()=>i});var n=r(860);const i={ERROR:"ERROR",WARN:"WARN",INFO:"INFO",DEBUG:"DEBUG",TRACE:"TRACE"},o="log",a=n.K7.logging},3785:(e,t,r)=>{"use strict";r.d(t,{R:()=>c,b:()=>u});var n=r(9908),i=r(1863),o=r(860),a=r(3969),s=r(993);function c(e,t,r={},c=s.p_.INFO){(0,n.p)(a.xV,["API/logging/".concat(c.toLowerCase(),"/called")],void 0,o.K7.metrics,e),(0,n.p)(s.ET,[(0,i.t)(),t,r,c],void 0,o.K7.logging,e)}function u(e){return"string"==typeof e&&Object.values(s.p_).some((t=>t===e.toUpperCase().trim()))}},3969:(e,t,r)=>{"use strict";r.d(t,{TZ:()=>n,XG:()=>s,rs:()=>i,xV:()=>a,z_:()=>o});const n=r(860).K7.metrics,i="sm",o="cm",a="storeSupportabilityMetrics",s="storeEventMetrics"},6630:(e,t,r)=>{"use strict";r.d(t,{T:()=>n});const n=r(860).K7.pageViewEvent},782:(e,t,r)=>{"use strict";r.d(t,{T:()=>n});const n=r(860).K7.pageViewTiming},6344:(e,t,r)=>{"use strict";r.d(t,{BB:()=>d,G4:()=>o,Qb:()=>l,TZ:()=>i,Ug:()=>a,_s:()=>s,bc:()=>u,yP:()=>c});var n=r(2614);const i=r(860).K7.sessionReplay,o={RECORD:"recordReplay",PAUSE:"pauseReplay",REPLAY_RUNNING:"replayRunning",ERROR_DURING_REPLAY:"errorDuringReplay"},a=.12,s={DomContentLoaded:0,Load:1,FullSnapshot:2,IncrementalSnapshot:3,Meta:4,Custom:5},c={[n.g.ERROR]:15e3,[n.g.FULL]:3e5,[n.g.OFF]:0},u={RESET:{message:"Session was reset",sm:"Reset"},IMPORT:{message:"Recorder failed to import",sm:"Import"},TOO_MANY:{message:"429: Too Many Requests",sm:"Too-Many"},TOO_BIG:{message:"Payload was too large",sm:"Too-Big"},CROSS_TAB:{message:"Session Entity was set to OFF on another tab",sm:"Cross-Tab"},ENTITLEMENTS:{message:"Session Replay is not allowed and will not be started",sm:"Entitlement"}},d=5e3,l={API:"api"}},5270:(e,t,r)=>{"use strict";r.d(t,{Aw:()=>c,CT:()=>u,SR:()=>s});var n=r(384),i=r(9417),o=r(7767),a=r(6154);function s(e){return!!(0,n.dV)().o.MO&&(0,o.V)(e)&&!0===(0,i.gD)(e,"session_trace.enabled")}function c(e){return!0===(0,i.gD)(e,"session_replay.preload")&&s(e)}function u(e,t){const r=t.correctAbsoluteTimestamp(e);return{originalTimestamp:e,correctedTimestamp:r,timestampDiff:e-r,originTime:a.WN,correctedOriginTime:t.correctedOriginTime,originTimeDiff:Math.floor(a.WN-t.correctedOriginTime)}}},3738:(e,t,r)=>{"use strict";r.d(t,{He:()=>i,Kp:()=>s,Lc:()=>u,Rz:()=>d,TZ:()=>n,bD:()=>o,d3:()=>a,jx:()=>l,uP:()=>c});const n=r(860).K7.sessionTrace,i="bstResource",o="resource",a="-start",s="-end",c="fn"+a,u="fn"+s,d="pushState",l=1e3},3962:(e,t,r)=>{"use strict";r.d(t,{AM:()=>o,O2:()=>s,Qu:()=>c,TZ:()=>a,ih:()=>u,tC:()=>i});var n=r(860);const i=["click","keydown","submit"],o="api",a=n.K7.softNav,s={INITIAL_PAGE_LOAD:"",ROUTE_CHANGE:1,UNSPECIFIED:2},c={INTERACTION:1,AJAX:2,CUSTOM_END:3,CUSTOM_TRACER:4},u={IP:"in progress",FIN:"finished",CAN:"cancelled"}},7378:(e,t,r)=>{"use strict";r.d(t,{$p:()=>x,BR:()=>b,Kp:()=>R,L3:()=>y,Lc:()=>c,NC:()=>o,SG:()=>d,TZ:()=>i,U6:()=>p,UT:()=>m,d3:()=>w,dT:()=>f,e5:()=>A,gx:()=>v,l9:()=>l,oW:()=>h,op:()=>g,rw:()=>u,tH:()=>E,uP:()=>s,wW:()=>T,xq:()=>a});var n=r(384);const i=r(860).K7.spa,o=["click","submit","keypress","keydown","keyup","change"],a=999,s="fn-start",c="fn-end",u="cb-start",d="api-ixn-",l="remaining",f="interaction",h="spaNode",p="jsonpNode",g="fetch-start",m="fetch-done",v="fetch-body-",b="jsonp-end",y=(0,n.dV)().o.ST,w="-start",R="-end",x="-body",T="cb"+R,A="jsTime",E="fetch"},4234:(e,t,r)=>{"use strict";r.d(t,{W:()=>o});var n=r(7836),i=r(1687);class o{constructor(e,t){this.agentIdentifier=e,this.ee=n.ee.get(e),this.featureName=t,this.blocked=!1}deregisterDrain(){(0,i.x3)(this.agentIdentifier,this.featureName)}}},7767:(e,t,r)=>{"use strict";r.d(t,{V:()=>o});var n=r(9417),i=r(6154);const o=e=>i.RI&&!0===(0,n.gD)(e,"privacy.cookies_enabled")},425:(e,t,r)=>{"use strict";r.d(t,{j:()=>j});var n=r(860),i=r(2555),o=r(3371),a=r(9908),s=r(7836),c=r(1687),u=r(5289),d=r(6154),l=r(944),f=r(3969),h=r(384),p=r(6344);const g=["setErrorHandler","finished","addToTrace","addRelease","addPageAction","setCurrentRouteName","setPageViewName","setCustomAttribute","interaction","noticeError","setUserId","setApplicationVersion","start",p.G4.RECORD,p.G4.PAUSE,"log","wrapLogger"],m=["setErrorHandler","finished","addToTrace","addRelease"];var v=r(1863),b=r(2614),y=r(993),w=r(3785),R=r(2646),x=r(3434);function T(e,t,r,n){if("object"!=typeof t||!t||"string"!=typeof r||!r||"function"!=typeof t[r])return(0,l.R)(29);const i=function(e){return(e||s.ee).get("logger")}(e),o=(0,x.YM)(i),a=new R.y(s.P);return a.level=n.level,a.customAttributes=n.customAttributes,o.inPlace(t,[r],"wrap-logger-",a),i}function A(){const e=(0,h.pV)();g.forEach((t=>{e[t]=(...r)=>function(t,...r){let n=[];return Object.values(e.initializedAgents).forEach((e=>{e&&e.api?e.exposed&&e.api[t]&&n.push(e.api[t](...r)):(0,l.R)(38,t)})),n.length>1?n:n[0]}(t,...r)}))}const E={};var S=r(9417),N=r(5603),O=r(5284);const _=e=>{const t=e.startsWith("http");e+="/",r.p=t?e:"https://"+e};let I=!1;function j(e,t={},g,R){let{init:x,info:j,loader_config:P,runtime:C={},exposed:k=!0}=t;C.loaderType=g;const L=(0,h.pV)();j||(x=L.init,j=L.info,P=L.loader_config),(0,S.xN)(e.agentIdentifier,x||{}),(0,N.a)(e.agentIdentifier,P||{}),j.jsAttributes??={},d.bv&&(j.jsAttributes.isWorker=!0),(0,i.x1)(e.agentIdentifier,j);const H=(0,S.D0)(e.agentIdentifier),D=[j.beacon,j.errorBeacon];I||(H.proxy.assets&&(_(H.proxy.assets),D.push(H.proxy.assets)),H.proxy.beacon&&D.push(H.proxy.beacon),A(),(0,h.US)("activatedFeatures",O.B),e.runSoftNavOverSpa&&=!0===H.soft_navigations.enabled&&H.feature_flags.includes("soft_nav")),C.denyList=[...H.ajax.deny_list||[],...H.ajax.block_internal?D:[]],C.ptid=e.agentIdentifier,(0,o.V)(e.agentIdentifier,C),e.ee=s.ee.get(e.agentIdentifier),void 0===e.api&&(e.api=function(e,t,h=!1){t||(0,c.Ak)(e,"api");const g={};var R=s.ee.get(e),x=R.get("tracer");E[e]=b.g.OFF,R.on(p.G4.REPLAY_RUNNING,(t=>{E[e]=t}));var A="api-",S=A+"ixn-";function N(t,r,n,o){const a=(0,i.Vp)(e);return null===r?delete a.jsAttributes[t]:(0,i.x1)(e,{...a,jsAttributes:{...a.jsAttributes,[t]:r}}),I(A,n,!0,o||null===r?"session":void 0)(t,r)}function O(){}g.log=function(e,{customAttributes:t={},level:r=y.p_.INFO}={}){(0,a.p)(f.xV,["API/log/called"],void 0,n.K7.metrics,R),(0,w.R)(R,e,t,r)},g.wrapLogger=(e,t,{customAttributes:r={},level:i=y.p_.INFO}={})=>{(0,a.p)(f.xV,["API/wrapLogger/called"],void 0,n.K7.metrics,R),T(R,e,t,{customAttributes:r,level:i})},m.forEach((e=>{g[e]=I(A,e,!0,"api")})),g.addPageAction=I(A,"addPageAction",!0,n.K7.genericEvents),g.setPageViewName=function(t,r){if("string"==typeof t)return"/"!==t.charAt(0)&&(t="/"+t),(0,o.f)(e).customTransaction=(r||"http://custom.transaction")+t,I(A,"setPageViewName",!0)()},g.setCustomAttribute=function(e,t,r=!1){if("string"==typeof e){if(["string","number","boolean"].includes(typeof t)||null===t)return N(e,t,"setCustomAttribute",r);(0,l.R)(40,typeof t)}else(0,l.R)(39,typeof e)},g.setUserId=function(e){if("string"==typeof e||null===e)return N("enduser.id",e,"setUserId",!0);(0,l.R)(41,typeof e)},g.setApplicationVersion=function(e){if("string"==typeof e||null===e)return N("application.version",e,"setApplicationVersion",!1);(0,l.R)(42,typeof e)},g.start=()=>{try{(0,a.p)(f.xV,["API/start/called"],void 0,n.K7.metrics,R),R.emit("manual-start-all")}catch(e){(0,l.R)(23,e)}},g[p.G4.RECORD]=function(){(0,a.p)(f.xV,["API/recordReplay/called"],void 0,n.K7.metrics,R),(0,a.p)(p.G4.RECORD,[],void 0,n.K7.sessionReplay,R)},g[p.G4.PAUSE]=function(){(0,a.p)(f.xV,["API/pauseReplay/called"],void 0,n.K7.metrics,R),(0,a.p)(p.G4.PAUSE,[],void 0,n.K7.sessionReplay,R)},g.interaction=function(e){return(new O).get("object"==typeof e?e:{})};const _=O.prototype={createTracer:function(e,t){var r={},i=this,o="function"==typeof t;return(0,a.p)(f.xV,["API/createTracer/called"],void 0,n.K7.metrics,R),h||(0,a.p)(S+"tracer",[(0,v.t)(),e,r],i,n.K7.spa,R),function(){if(x.emit((o?"":"no-")+"fn-start",[(0,v.t)(),i,o],r),o)try{return t.apply(this,arguments)}catch(e){const t="string"==typeof e?new Error(e):e;throw x.emit("fn-err",[arguments,this,t],r),t}finally{x.emit("fn-end",[(0,v.t)()],r)}}}};function I(e,t,r,i){return function(){return(0,a.p)(f.xV,["API/"+t+"/called"],void 0,n.K7.metrics,R),i&&(0,a.p)(e+t,[(0,v.t)(),...arguments],r?null:this,i,R),r?void 0:this}}function j(){r.e(478).then(r.bind(r,8778)).then((({setAPI:t})=>{t(e),(0,c.Ze)(e,"api")})).catch((e=>{(0,l.R)(27,e),R.abort()}))}return["actionText","setName","setAttribute","save","ignore","onEnd","getContext","end","get"].forEach((e=>{_[e]=I(S,e,void 0,h?n.K7.softNav:n.K7.spa)})),g.setCurrentRouteName=h?I(S,"routeName",void 0,n.K7.softNav):I(A,"routeName",!0,n.K7.spa),g.noticeError=function(t,r){"string"==typeof t&&(t=new Error(t)),(0,a.p)(f.xV,["API/noticeError/called"],void 0,n.K7.metrics,R),(0,a.p)("err",[t,(0,v.t)(),!1,r,!!E[e]],void 0,n.K7.jserrors,R)},d.RI?(0,u.GG)((()=>j()),!0):j(),g}(e.agentIdentifier,R,e.runSoftNavOverSpa)),void 0===e.exposed&&(e.exposed=k),I=!0}},8374:(e,t,r)=>{r.nc=(()=>{try{return document?.currentScript?.nonce}catch(e){}return""})()},860:(e,t,r)=>{"use strict";r.d(t,{$J:()=>o,K7:()=>n,P3:()=>i});const n={ajax:"ajax",genericEvents:"generic_events",jserrors:"jserrors",logging:"logging",metrics:"metrics",pageAction:"page_action",pageViewEvent:"page_view_event",pageViewTiming:"page_view_timing",sessionReplay:"session_replay",sessionTrace:"session_trace",softNav:"soft_navigations",spa:"spa"},i={[n.pageViewEvent]:1,[n.pageViewTiming]:2,[n.metrics]:3,[n.jserrors]:4,[n.spa]:5,[n.ajax]:6,[n.sessionTrace]:7,[n.softNav]:8,[n.sessionReplay]:9,[n.logging]:10,[n.genericEvents]:11},o={[n.pageViewTiming]:"events",[n.ajax]:"events",[n.spa]:"events",[n.softNav]:"events",[n.metrics]:"jserrors",[n.jserrors]:"jserrors",[n.sessionTrace]:"browser/blobs",[n.sessionReplay]:"browser/blobs",[n.logging]:"browser/logs",[n.genericEvents]:"ins"}}},n={};function i(e){var t=n[e];if(void 0!==t)return t.exports;var o=n[e]={exports:{}};return r[e](o,o.exports,i),o.exports}i.m=r,i.d=(e,t)=>{for(var r in t)i.o(t,r)&&!i.o(e,r)&&Object.defineProperty(e,r,{enumerable:!0,get:t[r]})},i.f={},i.e=e=>Promise.all(Object.keys(i.f).reduce(((t,r)=>(i.f[r](e,t),t)),[])),i.u=e=>({212:"nr-spa-compressor",249:"nr-spa-recorder",478:"nr-spa"}[e]+"-1.274.0.min.js"),i.o=(e,t)=>Object.prototype.hasOwnProperty.call(e,t),e={},t="NRBA-1.274.0.PROD:",i.l=(r,n,o,a)=>{if(e[r])e[r].push(n);else{var s,c;if(void 0!==o)for(var u=document.getElementsByTagName("script"),d=0;d<u.length;d++){var l=u[d];if(l.getAttribute("src")==r||l.getAttribute("data-webpack")==t+o){s=l;break}}if(!s){c=!0;var f={478:"sha512-1vUqEfJPB8Pihje9mv5CfYgkitO1FWcS+UQb84DbXqP8oYctRv4/lzl/MzNLPlRhcY1WVDBGL20I8vm6s2VV7g==",249:"sha512-Y/BeZAh6VSTmUtUNmS5XdyKxL92s30Fyyj8xVW76HSPxcKItL4+x2+kGMZc8pMJnUpZDz1L4eftZQAJh3D8NnA==",212:"sha512-Gn2tQ3qog5Yhrx/gRutkSTYPp+7nkKFt4/mIXg99LxcNpMDAYJZDBYmAACdoHNM86+iq1F3cBcQotFNzjIX8bw=="};(s=document.createElement("script")).charset="utf-8",s.timeout=120,i.nc&&s.setAttribute("nonce",i.nc),s.setAttribute("data-webpack",t+o),s.src=r,0!==s.src.indexOf(window.location.origin+"/")&&(s.crossOrigin="anonymous"),f[a]&&(s.integrity=f[a])}e[r]=[n];var h=(t,n)=>{s.onerror=s.onload=null,clearTimeout(p);var i=e[r];if(delete e[r],s.parentNode&&s.parentNode.removeChild(s),i&&i.forEach((e=>e(n))),t)return t(n)},p=setTimeout(h.bind(null,void 0,{type:"timeout",target:s}),12e4);s.onerror=h.bind(null,s.onerror),s.onload=h.bind(null,s.onload),c&&document.head.appendChild(s)}},i.r=e=>{"undefined"!=typeof Symbol&&Symbol.toStringTag&&Object.defineProperty(e,Symbol.toStringTag,{value:"Module"}),Object.defineProperty(e,"__esModule",{value:!0})},i.p="https://js-agent.newrelic.com/",(()=>{var e={38:0,788:0};i.f.j=(t,r)=>{var n=i.o(e,t)?e[t]:void 0;if(0!==n)if(n)r.push(n[2]);else{var o=new Promise(((r,i)=>n=e[t]=[r,i]));r.push(n[2]=o);var a=i.p+i.u(t),s=new Error;i.l(a,(r=>{if(i.o(e,t)&&(0!==(n=e[t])&&(e[t]=void 0),n)){var o=r&&("load"===r.type?"missing":r.type),a=r&&r.target&&r.target.src;s.message="Loading chunk "+t+" failed.\n("+o+": "+a+")",s.name="ChunkLoadError",s.type=o,s.request=a,n[1](s)}}),"chunk-"+t,t)}};var t=(t,r)=>{var n,o,[a,s,c]=r,u=0;if(a.some((t=>0!==e[t]))){for(n in s)i.o(s,n)&&(i.m[n]=s[n]);if(c)c(i)}for(t&&t(r);u<a.length;u++)o=a[u],i.o(e,o)&&e[o]&&e[o][0](),e[o]=0},r=self["webpackChunk:NRBA-1.274.0.PROD"]=self["webpackChunk:NRBA-1.274.0.PROD"]||[];r.forEach(t.bind(null,0)),r.push=t.bind(null,r.push.bind(r))})(),(()=>{"use strict";i(8374);var e=i(944),t=i(6344),r=i(9566);class n{agentIdentifier;constructor(e=(0,r.LA)(16)){this.agentIdentifier=e}#e(t,...r){if("function"==typeof this.api?.[t])return this.api[t](...r);(0,e.R)(35,t)}addPageAction(e,t){return this.#e("addPageAction",e,t)}setPageViewName(e,t){return this.#e("setPageViewName",e,t)}setCustomAttribute(e,t,r){return this.#e("setCustomAttribute",e,t,r)}noticeError(e,t){return this.#e("noticeError",e,t)}setUserId(e){return this.#e("setUserId",e)}setApplicationVersion(e){return this.#e("setApplicationVersion",e)}setErrorHandler(e){return this.#e("setErrorHandler",e)}addRelease(e,t){return this.#e("addRelease",e,t)}log(e,t){return this.#e("log",e,t)}}class o extends n{#e(t,...r){if("function"==typeof this.api?.[t])return this.api[t](...r);(0,e.R)(35,t)}start(){return this.#e("start")}finished(e){return this.#e("finished",e)}recordReplay(){return this.#e(t.G4.RECORD)}pauseReplay(){return this.#e(t.G4.PAUSE)}addToTrace(e){return this.#e("addToTrace",e)}setCurrentRouteName(e){return this.#e("setCurrentRouteName",e)}interaction(){return this.#e("interaction")}wrapLogger(e,t,r){return this.#e("wrapLogger",e,t,r)}}var a=i(860),s=i(9417);const c=Object.values(a.K7);function u(e){const t={};return c.forEach((r=>{t[r]=function(e,t){return!0===(0,s.gD)(t,"".concat(e,".enabled"))}(r,e)})),t}var d=i(425);var l=i(1687),f=i(4234),h=i(5289),p=i(6154),g=i(5270),m=i(7767),v=i(6389);class b extends f.W{constructor(e,t,r=!0){super(e.agentIdentifier,t),this.auto=r,this.abortHandler=void 0,this.featAggregate=void 0,this.onAggregateImported=void 0,!1===e.init[this.featureName].autoStart&&(this.auto=!1),this.auto?(0,l.Ak)(e.agentIdentifier,t):this.ee.on("manual-start-all",(0,v.J)((()=>{(0,l.Ak)(e.agentIdentifier,this.featureName),this.auto=!0,this.importAggregator(e)})))}importAggregator(t,r={}){if(this.featAggregate||!this.auto)return;let n;this.onAggregateImported=new Promise((e=>{n=e}));const o=async()=>{let o;try{if((0,m.V)(this.agentIdentifier)){const{setupAgentSession:e}=await i.e(478).then(i.bind(i,6526));o=e(t)}}catch(t){(0,e.R)(20,t),this.ee.emit("internal-error",[t]),this.featureName===a.K7.sessionReplay&&this.abortHandler?.()}try{if(t.sharedAggregator)await t.sharedAggregator;else{t.sharedAggregator=i.e(478).then(i.bind(i,9337));const{EventAggregator:e}=await t.sharedAggregator;t.sharedAggregator=new e}if(!this.#t(this.featureName,o))return(0,l.Ze)(this.agentIdentifier,this.featureName),void n(!1);const{lazyFeatureLoader:e}=await i.e(478).then(i.bind(i,6103)),{Aggregate:a}=await e(this.featureName,"aggregate");this.featAggregate=new a(t,r),n(!0)}catch(t){(0,e.R)(34,t),this.abortHandler?.(),(0,l.Ze)(this.agentIdentifier,this.featureName,!0),n(!1),this.ee&&this.ee.abort()}};p.RI?(0,h.GG)((()=>o()),!0):o()}#t(e,t){switch(e){case a.K7.sessionReplay:return(0,g.SR)(this.agentIdentifier)&&!!t;case a.K7.sessionTrace:return!!t;default:return!0}}}var y=i(6630);class w extends b{static featureName=y.T;constructor(e,t=!0){super(e,y.T,t),this.importAggregator(e)}}var R=i(384);var x=i(9908),T=i(2843),A=i(3878),E=i(782),S=i(1863);class N extends b{static featureName=E.T;constructor(e,t=!0){super(e,E.T,t),p.RI&&((0,T.u)((()=>(0,x.p)("docHidden",[(0,S.t)()],void 0,E.T,this.ee)),!0),(0,A.sp)("pagehide",(()=>(0,x.p)("winPagehide",[(0,S.t)()],void 0,E.T,this.ee))),this.importAggregator(e))}}var O=i(3969);class _ extends b{static featureName=O.TZ;constructor(e,t=!0){super(e,O.TZ,t),this.importAggregator(e)}}var I=i(6774),j=i(3304);class P{constructor(e,t,r,n,i){this.name="UncaughtError",this.message="string"==typeof e?e:(0,j.A)(e),this.sourceURL=t,this.line=r,this.column=n,this.__newrelic=i}}function C(e){return H(e)?e:new P(void 0!==e?.message?e.message:e,e?.filename||e?.sourceURL,e?.lineno||e?.line,e?.colno||e?.col,e?.__newrelic)}function k(e){const t="Unhandled Promise Rejection";if(!e?.reason)return;if(H(e.reason))try{return e.reason.message=t+": "+e.reason.message,C(e.reason)}catch(t){return C(e.reason)}const r=C(e.reason);return r.message=t+": "+r?.message,r}function L(e){if(e.error instanceof SyntaxError&&!/:\d+$/.test(e.error.stack?.trim())){const t=new P(e.message,e.filename,e.lineno,e.colno,e.error.__newrelic);return t.name=SyntaxError.name,t}return H(e.error)?e.error:C(e)}function H(e){return e instanceof Error&&!!e.stack}class D extends b{static featureName=I.T;#r=!1;constructor(e,r=!0){super(e,I.T,r);try{this.removeOnAbort=new AbortController}catch(e){}this.ee.on("internal-error",(e=>{this.abortHandler&&(0,x.p)("ierr",[C(e),(0,S.t)(),!0,{},this.#r],void 0,this.featureName,this.ee)})),this.ee.on(t.G4.REPLAY_RUNNING,(e=>{this.#r=e})),p.gm.addEventListener("unhandledrejection",(e=>{this.abortHandler&&(0,x.p)("err",[k(e),(0,S.t)(),!1,{unhandledPromiseRejection:1},this.#r],void 0,this.featureName,this.ee)}),(0,A.jT)(!1,this.removeOnAbort?.signal)),p.gm.addEventListener("error",(e=>{this.abortHandler&&(0,x.p)("err",[L(e),(0,S.t)(),!1,{},this.#r],void 0,this.featureName,this.ee)}),(0,A.jT)(!1,this.removeOnAbort?.signal)),this.abortHandler=this.#n,this.importAggregator(e)}#n(){this.removeOnAbort?.abort(),this.abortHandler=void 0}}var M=i(8990);let K=1;const U="nr@id";function V(e){const t=typeof e;return!e||"object"!==t&&"function"!==t?-1:e===p.gm?0:(0,M.I)(e,U,(function(){return K++}))}function G(e){if("string"==typeof e&&e.length)return e.length;if("object"==typeof e){if("undefined"!=typeof ArrayBuffer&&e instanceof ArrayBuffer&&e.byteLength)return e.byteLength;if("undefined"!=typeof Blob&&e instanceof Blob&&e.size)return e.size;if(!("undefined"!=typeof FormData&&e instanceof FormData))try{return(0,j.A)(e).length}catch(e){return}}}var F=i(8139),B=i(7836),W=i(3434);const z={},q=["open","send"];function Z(t){var r=t||B.ee;const n=function(e){return(e||B.ee).get("xhr")}(r);if(z[n.debugId]++)return n;z[n.debugId]=1,(0,F.u)(r);var i=(0,W.YM)(n),o=p.gm.XMLHttpRequest,a=p.gm.MutationObserver,s=p.gm.Promise,c=p.gm.setInterval,u="readystatechange",d=["onload","onerror","onabort","onloadstart","onloadend","onprogress","ontimeout"],l=[],f=p.gm.XMLHttpRequest=function(t){const r=new o(t),a=n.context(r);try{n.emit("new-xhr",[r],a),r.addEventListener(u,(s=a,function(){var e=this;e.readyState>3&&!s.resolved&&(s.resolved=!0,n.emit("xhr-resolved",[],e)),i.inPlace(e,d,"fn-",y)}),(0,A.jT)(!1))}catch(t){(0,e.R)(15,t);try{n.emit("internal-error",[t])}catch(e){}}var s;return r};function h(e,t){i.inPlace(t,["onreadystatechange"],"fn-",y)}if(function(e,t){for(var r in e)t[r]=e[r]}(o,f),f.prototype=o.prototype,i.inPlace(f.prototype,q,"-xhr-",y),n.on("send-xhr-start",(function(e,t){h(e,t),function(e){l.push(e),a&&(g?g.then(b):c?c(b):(m=-m,v.data=m))}(t)})),n.on("open-xhr-start",h),a){var g=s&&s.resolve();if(!c&&!s){var m=1,v=document.createTextNode(m);new a(b).observe(v,{characterData:!0})}}else r.on("fn-end",(function(e){e[0]&&e[0].type===u||b()}));function b(){for(var e=0;e<l.length;e++)h(0,l[e]);l.length&&(l=[])}function y(e,t){return t}return n}var Y="fetch-",X=Y+"body-",J=["arrayBuffer","blob","json","text","formData"],Q=p.gm.Request,ee=p.gm.Response,te="prototype";const re={};function ne(e){const t=function(e){return(e||B.ee).get("fetch")}(e);if(!(Q&&ee&&p.gm.fetch))return t;if(re[t.debugId]++)return t;function r(e,r,n){var i=e[r];"function"==typeof i&&(e[r]=function(){var e,r=[...arguments],o={};t.emit(n+"before-start",[r],o),o[B.P]&&o[B.P].dt&&(e=o[B.P].dt);var a=i.apply(this,r);return t.emit(n+"start",[r,e],a),a.then((function(e){return t.emit(n+"end",[null,e],a),e}),(function(e){throw t.emit(n+"end",[e],a),e}))})}return re[t.debugId]=1,J.forEach((e=>{r(Q[te],e,X),r(ee[te],e,X)})),r(p.gm,"fetch",Y),t.on(Y+"end",(function(e,r){var n=this;if(r){var i=r.headers.get("content-length");null!==i&&(n.rxSize=i),t.emit(Y+"done",[null,r],n)}else t.emit(Y+"done",[e],n)})),t}var ie=i(7485),oe=i(5603);class ae{constructor(e){this.agentIdentifier=e}generateTracePayload(e){if(!this.shouldGenerateTrace(e))return null;var t=(0,oe.o)(this.agentIdentifier);if(!t)return null;var n=(t.accountID||"").toString()||null,i=(t.agentID||"").toString()||null,o=(t.trustKey||"").toString()||null;if(!n||!i)return null;var a=(0,r.ZF)(),s=(0,r.el)(),c=Date.now(),u={spanId:a,traceId:s,timestamp:c};return(e.sameOrigin||this.isAllowedOrigin(e)&&this.useTraceContextHeadersForCors())&&(u.traceContextParentHeader=this.generateTraceContextParentHeader(a,s),u.traceContextStateHeader=this.generateTraceContextStateHeader(a,c,n,i,o)),(e.sameOrigin&&!this.excludeNewrelicHeader()||!e.sameOrigin&&this.isAllowedOrigin(e)&&this.useNewrelicHeaderForCors())&&(u.newrelicHeader=this.generateTraceHeader(a,s,c,n,i,o)),u}generateTraceContextParentHeader(e,t){return"00-"+t+"-"+e+"-01"}generateTraceContextStateHeader(e,t,r,n,i){return i+"@nr=0-1-"+r+"-"+n+"-"+e+"----"+t}generateTraceHeader(e,t,r,n,i,o){if(!("function"==typeof p.gm?.btoa))return null;var a={v:[0,1],d:{ty:"Browser",ac:n,ap:i,id:e,tr:t,ti:r}};return o&&n!==o&&(a.d.tk=o),btoa((0,j.A)(a))}shouldGenerateTrace(e){return this.isDtEnabled()&&this.isAllowedOrigin(e)}isAllowedOrigin(e){var t=!1,r={};if((0,s.gD)(this.agentIdentifier,"distributed_tracing")&&(r=(0,s.D0)(this.agentIdentifier).distributed_tracing),e.sameOrigin)t=!0;else if(r.allowed_origins instanceof Array)for(var n=0;n<r.allowed_origins.length;n++){var i=(0,ie.D)(r.allowed_origins[n]);if(e.hostname===i.hostname&&e.protocol===i.protocol&&e.port===i.port){t=!0;break}}return t}isDtEnabled(){var e=(0,s.gD)(this.agentIdentifier,"distributed_tracing");return!!e&&!!e.enabled}excludeNewrelicHeader(){var e=(0,s.gD)(this.agentIdentifier,"distributed_tracing");return!!e&&!!e.exclude_newrelic_header}useNewrelicHeaderForCors(){var e=(0,s.gD)(this.agentIdentifier,"distributed_tracing");return!!e&&!1!==e.cors_use_newrelic_header}useTraceContextHeadersForCors(){var e=(0,s.gD)(this.agentIdentifier,"distributed_tracing");return!!e&&!!e.cors_use_tracecontext_headers}}var se=i(9300),ce=i(7295),ue=["load","error","abort","timeout"],de=ue.length,le=(0,R.dV)().o.REQ,fe=(0,R.dV)().o.XHR;class he extends b{static featureName=se.T;constructor(e,t=!0){super(e,se.T,t),this.dt=new ae(e.agentIdentifier),this.handler=(e,t,r,n)=>(0,x.p)(e,t,r,n,this.ee);try{const e={xmlhttprequest:"xhr",fetch:"fetch",beacon:"beacon"};p.gm?.performance?.getEntriesByType("resource").forEach((t=>{if(t.initiatorType in e&&0!==t.responseStatus){const r={status:t.responseStatus},n={rxSize:t.transferSize,duration:Math.floor(t.duration),cbTime:0};pe(r,t.name),this.handler("xhr",[r,n,t.startTime,t.responseEnd,e[t.initiatorType]],void 0,a.K7.ajax)}}))}catch(e){}ne(this.ee),Z(this.ee),function(e,t,r,n){function i(e){var t=this;t.totalCbs=0,t.called=0,t.cbTime=0,t.end=R,t.ended=!1,t.xhrGuids={},t.lastSize=null,t.loadCaptureCalled=!1,t.params=this.params||{},t.metrics=this.metrics||{},e.addEventListener("load",(function(r){T(t,e)}),(0,A.jT)(!1)),p.lR||e.addEventListener("progress",(function(e){t.lastSize=e.loaded}),(0,A.jT)(!1))}function o(e){this.params={method:e[0]},pe(this,e[1]),this.metrics={}}function s(t,r){e.loader_config.xpid&&this.sameOrigin&&r.setRequestHeader("X-NewRelic-ID",e.loader_config.xpid);var i=n.generateTracePayload(this.parsedOrigin);if(i){var o=!1;i.newrelicHeader&&(r.setRequestHeader("newrelic",i.newrelicHeader),o=!0),i.traceContextParentHeader&&(r.setRequestHeader("traceparent",i.traceContextParentHeader),i.traceContextStateHeader&&r.setRequestHeader("tracestate",i.traceContextStateHeader),o=!0),o&&(this.dt=i)}}function c(e,r){var n=this.metrics,i=e[0],o=this;if(n&&i){var a=G(i);a&&(n.txSize=a)}this.startTime=(0,S.t)(),this.body=i,this.listener=function(e){try{"abort"!==e.type||o.loadCaptureCalled||(o.params.aborted=!0),("load"!==e.type||o.called===o.totalCbs&&(o.onloadCalled||"function"!=typeof r.onload)&&"function"==typeof o.end)&&o.end(r)}catch(e){try{t.emit("internal-error",[e])}catch(e){}}};for(var s=0;s<de;s++)r.addEventListener(ue[s],this.listener,(0,A.jT)(!1))}function u(e,t,r){this.cbTime+=e,t?this.onloadCalled=!0:this.called+=1,this.called!==this.totalCbs||!this.onloadCalled&&"function"==typeof r.onload||"function"!=typeof this.end||this.end(r)}function d(e,t){var r=""+V(e)+!!t;this.xhrGuids&&!this.xhrGuids[r]&&(this.xhrGuids[r]=!0,this.totalCbs+=1)}function l(e,t){var r=""+V(e)+!!t;this.xhrGuids&&this.xhrGuids[r]&&(delete this.xhrGuids[r],this.totalCbs-=1)}function f(){this.endTime=(0,S.t)()}function h(e,r){r instanceof fe&&"load"===e[0]&&t.emit("xhr-load-added",[e[1],e[2]],r)}function g(e,r){r instanceof fe&&"load"===e[0]&&t.emit("xhr-load-removed",[e[1],e[2]],r)}function m(e,t,r){t instanceof fe&&("onload"===r&&(this.onload=!0),("load"===(e[0]&&e[0].type)||this.onload)&&(this.xhrCbStart=(0,S.t)()))}function v(e,r){this.xhrCbStart&&t.emit("xhr-cb-time",[(0,S.t)()-this.xhrCbStart,this.onload,r],r)}function b(e){var t,r=e[1]||{};if("string"==typeof e[0]?0===(t=e[0]).length&&p.RI&&(t=""+p.gm.location.href):e[0]&&e[0].url?t=e[0].url:p.gm?.URL&&e[0]&&e[0]instanceof URL?t=e[0].href:"function"==typeof e[0].toString&&(t=e[0].toString()),"string"==typeof t&&0!==t.length){t&&(this.parsedOrigin=(0,ie.D)(t),this.sameOrigin=this.parsedOrigin.sameOrigin);var i=n.generateTracePayload(this.parsedOrigin);if(i&&(i.newrelicHeader||i.traceContextParentHeader))if(e[0]&&e[0].headers)s(e[0].headers,i)&&(this.dt=i);else{var o={};for(var a in r)o[a]=r[a];o.headers=new Headers(r.headers||{}),s(o.headers,i)&&(this.dt=i),e.length>1?e[1]=o:e.push(o)}}function s(e,t){var r=!1;return t.newrelicHeader&&(e.set("newrelic",t.newrelicHeader),r=!0),t.traceContextParentHeader&&(e.set("traceparent",t.traceContextParentHeader),t.traceContextStateHeader&&e.set("tracestate",t.traceContextStateHeader),r=!0),r}}function y(e,t){this.params={},this.metrics={},this.startTime=(0,S.t)(),this.dt=t,e.length>=1&&(this.target=e[0]),e.length>=2&&(this.opts=e[1]);var r,n=this.opts||{},i=this.target;"string"==typeof i?r=i:"object"==typeof i&&i instanceof le?r=i.url:p.gm?.URL&&"object"==typeof i&&i instanceof URL&&(r=i.href),pe(this,r);var o=(""+(i&&i instanceof le&&i.method||n.method||"GET")).toUpperCase();this.params.method=o,this.body=n.body,this.txSize=G(n.body)||0}function w(e,t){if(this.endTime=(0,S.t)(),this.params||(this.params={}),(0,ce.iW)(this.params))return;let n;this.params.status=t?t.status:0,"string"==typeof this.rxSize&&this.rxSize.length>0&&(n=+this.rxSize);const i={txSize:this.txSize,rxSize:n,duration:(0,S.t)()-this.startTime};r("xhr",[this.params,i,this.startTime,this.endTime,"fetch"],this,a.K7.ajax)}function R(e){const t=this.params,n=this.metrics;if(!this.ended){this.ended=!0;for(let t=0;t<de;t++)e.removeEventListener(ue[t],this.listener,!1);t.aborted||(0,ce.iW)(t)||(n.duration=(0,S.t)()-this.startTime,this.loadCazptureCalled||4!==e.readyState?null==t.status&&(t.status=0):T(this,e),n.cbTime=this.cbTime,r("xhr",[t,n,this.startTime,this.endTime,"xhr"],this,a.K7.ajax))}}function T(e,r){e.params.status=r.status;var n=function(e,t){var r=e.responseType;return"json"===r&&null!==t?t:"arraybuffer"===r||"blob"===r||"json"===r?G(e.response):"text"===r||""===r||void 0===r?G(e.responseText):void 0}(r,e.lastSize);if(n&&(e.metrics.rxSize=n),e.sameOrigin){var i=r.getResponseHeader("X-NewRelic-App-Data");i&&((0,x.p)(O.rs,["Ajax/CrossApplicationTracing/Header/Seen"],void 0,a.K7.metrics,t),e.params.cat=i.split(", ").pop())}e.loadCaptureCalled=!0}t.on("new-xhr",i),t.on("open-xhr-start",o),t.on("open-xhr-end",s),t.on("send-xhr-start",c),t.on("xhr-cb-time",u),t.on("xhr-load-added",d),t.on("xhr-load-removed",l),t.on("xhr-resolved",f),t.on("addEventListener-end",h),t.on("removeEventListener-end",g),t.on("fn-end",v),t.on("fetch-before-start",b),t.on("fetch-start",y),t.on("fn-start",m),t.on("fetch-done",w)}(e,this.ee,this.handler,this.dt),this.importAggregator(e)}}function pe(e,t){var r=(0,ie.D)(t),n=e.params||e;n.hostname=r.hostname,n.port=r.port,n.protocol=r.protocol,n.host=r.hostname+":"+r.port,n.pathname=r.pathname,e.parsedOrigin=r,e.sameOrigin=r.sameOrigin}const ge={},me=["pushState","replaceState"];function ve(e){const t=function(e){return(e||B.ee).get("history")}(e);return!p.RI||ge[t.debugId]++||(ge[t.debugId]=1,(0,W.YM)(t).inPlace(window.history,me,"-")),t}var be=i(3738);const{He:ye,bD:we,d3:Re,Kp:xe,TZ:Te,Lc:Ae,uP:Ee,Rz:Se}=be;class Ne extends b{static featureName=Te;constructor(e,t=!0){super(e,Te,t);if(!(0,m.V)(this.agentIdentifier))return void this.deregisterDrain();const r=this.ee;let n;ve(r),this.eventsEE=(0,F.u)(r),this.eventsEE.on(Ee,(function(e,t){this.bstStart=(0,S.t)()})),this.eventsEE.on(Ae,(function(e,t){(0,x.p)("bst",[e[0],t,this.bstStart,(0,S.t)()],void 0,a.K7.sessionTrace,r)})),r.on(Se+Re,(function(e){this.time=(0,S.t)(),this.startPath=location.pathname+location.hash})),r.on(Se+xe,(function(e){(0,x.p)("bstHist",[location.pathname+location.hash,this.startPath,this.time],void 0,a.K7.sessionTrace,r)}));try{n=new PerformanceObserver((e=>{const t=e.getEntries();(0,x.p)(ye,[t],void 0,a.K7.sessionTrace,r)})),n.observe({type:we,buffered:!0})}catch(e){}this.importAggregator(e,{resourceObserver:n})}}var Oe=i(2614);class _e extends b{static featureName=t.TZ;#i;#o;constructor(e,r=!0){let n;super(e,t.TZ,r),this.replayRunning=!1,this.#o=e;try{n=JSON.parse(localStorage.getItem("".concat(Oe.H3,"_").concat(Oe.uh)))}catch(e){}(0,g.SR)(e.agentIdentifier)&&this.ee.on(t.G4.RECORD,(()=>this.#a())),this.#s(n)?(this.#i=n?.sessionReplayMode,this.#c()):this.importAggregator(e),this.ee.on("err",(e=>{this.replayRunning&&(this.errorNoticed=!0,(0,x.p)(t.G4.ERROR_DURING_REPLAY,[e],void 0,this.featureName,this.ee))})),this.ee.on(t.G4.REPLAY_RUNNING,(e=>{this.replayRunning=e}))}#s(e){return e&&(e.sessionReplayMode===Oe.g.FULL||e.sessionReplayMode===Oe.g.ERROR)||(0,g.Aw)(this.agentIdentifier)}#u=!1;async#c(e){if(!this.#u){this.#u=!0;try{const{Recorder:t}=await Promise.all([i.e(478),i.e(249)]).then(i.bind(i,8589));this.recorder??=new t({mode:this.#i,agentIdentifier:this.agentIdentifier,trigger:e,ee:this.ee}),this.recorder.startRecording(),this.abortHandler=this.recorder.stopRecording}catch(e){}this.importAggregator(this.#o,{recorder:this.recorder,errorNoticed:this.errorNoticed})}}#a(){this.featAggregate?this.featAggregate.mode!==Oe.g.FULL&&this.featAggregate.initializeRecording(Oe.g.FULL,!0):(this.#i=Oe.g.FULL,this.#c(t.Qb.API),this.recorder&&this.recorder.parent.mode!==Oe.g.FULL&&(this.recorder.parent.mode=Oe.g.FULL,this.recorder.stopRecording(),this.recorder.startRecording(),this.abortHandler=this.recorder.stopRecording))}}var Ie=i(3962);class je extends b{static featureName=Ie.TZ;constructor(e,t=!0){if(super(e,Ie.TZ,t),!p.RI||!(0,R.dV)().o.MO)return;const r=ve(this.ee);Ie.tC.forEach((e=>{(0,A.sp)(e,(e=>{a(e)}),!0)}));const n=()=>(0,x.p)("newURL",[(0,S.t)(),""+window.location],void 0,this.featureName,this.ee);r.on("pushState-end",n),r.on("replaceState-end",n);try{this.removeOnAbort=new AbortController}catch(e){}(0,A.sp)("popstate",(e=>(0,x.p)("newURL",[e.timeStamp,""+window.location],void 0,this.featureName,this.ee)),!0,this.removeOnAbort?.signal);let i=!1;const o=new((0,R.dV)().o.MO)(((e,t)=>{i||(i=!0,requestAnimationFrame((()=>{(0,x.p)("newDom",[(0,S.t)()],void 0,this.featureName,this.ee),i=!1})))})),a=(0,v.s)((e=>{(0,x.p)("newUIEvent",[e],void 0,this.featureName,this.ee),o.observe(document.body,{attributes:!0,childList:!0,subtree:!0,characterData:!0})}),100,{leading:!0});this.abortHandler=function(){this.removeOnAbort?.abort(),o.disconnect(),this.abortHandler=void 0},this.importAggregator(e,{domObserver:o})}}var Pe=i(7378);const Ce={},ke=["appendChild","insertBefore","replaceChild"];function Le(e){const t=function(e){return(e||B.ee).get("jsonp")}(e);if(!p.RI||Ce[t.debugId])return t;Ce[t.debugId]=!0;var r=(0,W.YM)(t),n=/[?&](?:callback|cb)=([^&#]+)/,i=/(.*)\.([^.]+)/,o=/^(\w+)(\.|$)(.*)$/;function a(e,t){if(!e)return t;const r=e.match(o),n=r[1];return a(r[3],t[n])}return r.inPlace(Node.prototype,ke,"dom-"),t.on("dom-start",(function(e){!function(e){if(!e||"string"!=typeof e.nodeName||"script"!==e.nodeName.toLowerCase())return;if("function"!=typeof e.addEventListener)return;var o=(s=e.src,c=s.match(n),c?c[1]:null);var s,c;if(!o)return;var u=function(e){var t=e.match(i);if(t&&t.length>=3)return{key:t[2],parent:a(t[1],window)};return{key:e,parent:window}}(o);if("function"!=typeof u.parent[u.key])return;var d={};function l(){t.emit("jsonp-end",[],d),e.removeEventListener("load",l,(0,A.jT)(!1)),e.removeEventListener("error",f,(0,A.jT)(!1))}function f(){t.emit("jsonp-error",[],d),t.emit("jsonp-end",[],d),e.removeEventListener("load",l,(0,A.jT)(!1)),e.removeEventListener("error",f,(0,A.jT)(!1))}r.inPlace(u.parent,[u.key],"cb-",d),e.addEventListener("load",l,(0,A.jT)(!1)),e.addEventListener("error",f,(0,A.jT)(!1)),t.emit("new-jsonp",[e.src],d)}(e[0])})),t}const He={};function De(e){const t=function(e){return(e||B.ee).get("promise")}(e);if(He[t.debugId])return t;He[t.debugId]=!0;var r=t.context,n=(0,W.YM)(t),i=p.gm.Promise;return i&&function(){function e(r){var o=t.context(),a=n(r,"executor-",o,null,!1);const s=Reflect.construct(i,[a],e);return t.context(s).getCtx=function(){return o},s}p.gm.Promise=e,Object.defineProperty(e,"name",{value:"Promise"}),e.toString=function(){return i.toString()},Object.setPrototypeOf(e,i),["all","race"].forEach((function(r){const n=i[r];e[r]=function(e){let i=!1;[...e||[]].forEach((e=>{this.resolve(e).then(a("all"===r),a(!1))}));const o=n.apply(this,arguments);return o;function a(e){return function(){t.emit("propagate",[null,!i],o,!1,!1),i=i||!e}}}})),["resolve","reject"].forEach((function(r){const n=i[r];e[r]=function(e){const r=n.apply(this,arguments);return e!==r&&t.emit("propagate",[e,!0],r,!1,!1),r}})),e.prototype=i.prototype;const o=i.prototype.then;i.prototype.then=function(...e){var i=this,a=r(i);a.promise=i,e[0]=n(e[0],"cb-",a,null,!1),e[1]=n(e[1],"cb-",a,null,!1);const s=o.apply(this,e);return a.nextPromise=s,t.emit("propagate",[i,!0],s,!1,!1),s},i.prototype.then[W.Jt]=o,t.on("executor-start",(function(e){e[0]=n(e[0],"resolve-",this,null,!1),e[1]=n(e[1],"resolve-",this,null,!1)})),t.on("executor-err",(function(e,t,r){e[1](r)})),t.on("cb-end",(function(e,r,n){t.emit("propagate",[n,!0],this.nextPromise,!1,!1)})),t.on("propagate",(function(e,r,n){this.getCtx&&!r||(this.getCtx=function(){if(e instanceof Promise)var r=t.context(e);return r&&r.getCtx?r.getCtx():this})}))}(),t}const Me={},Ke="setTimeout",Ue="setInterval",Ve="clearTimeout",Ge="-start",Fe=[Ke,"setImmediate",Ue,Ve,"clearImmediate"];function Be(e){const t=function(e){return(e||B.ee).get("timer")}(e);if(Me[t.debugId]++)return t;Me[t.debugId]=1;var r=(0,W.YM)(t);return r.inPlace(p.gm,Fe.slice(0,2),Ke+"-"),r.inPlace(p.gm,Fe.slice(2,3),Ue+"-"),r.inPlace(p.gm,Fe.slice(3),Ve+"-"),t.on(Ue+Ge,(function(e,t,n){e[0]=r(e[0],"fn-",null,n)})),t.on(Ke+Ge,(function(e,t,n){this.method=n,this.timerDuration=isNaN(e[1])?0:+e[1],e[0]=r(e[0],"fn-",this,n)})),t}const We={};function ze(e){const t=function(e){return(e||B.ee).get("mutation")}(e);if(!p.RI||We[t.debugId])return t;We[t.debugId]=!0;var r=(0,W.YM)(t),n=p.gm.MutationObserver;return n&&(window.MutationObserver=function(e){return this instanceof n?new n(r(e,"fn-")):n.apply(this,arguments)},MutationObserver.prototype=n.prototype),t}const{TZ:qe,d3:Ze,Kp:Ye,$p:Xe,wW:Je,e5:Qe,tH:$e,uP:et,rw:tt,Lc:rt}=Pe;class nt extends b{static featureName=qe;constructor(e,t=!0){if(super(e,qe,t),!p.RI)return;try{this.removeOnAbort=new AbortController}catch(e){}let r,n=0;const i=this.ee.get("tracer"),o=Le(this.ee),a=De(this.ee),s=Be(this.ee),c=Z(this.ee),u=this.ee.get("events"),d=ne(this.ee),l=ve(this.ee),f=ze(this.ee);function h(e,t){l.emit("newURL",[""+window.location,t])}function g(){n++,r=window.location.hash,this[et]=(0,S.t)()}function m(){n--,window.location.hash!==r&&h(0,!0);var e=(0,S.t)();this[Qe]=~~this[Qe]+e-this[et],this[rt]=e}function v(e,t){e.on(t,(function(){this[t]=(0,S.t)()}))}this.ee.on(et,g),a.on(tt,g),o.on(tt,g),this.ee.on(rt,m),a.on(Je,m),o.on(Je,m),this.ee.on("fn-err",((...t)=>{t[2]?.__newrelic?.[e.agentIdentifier]||(0,x.p)("function-err",[...t],void 0,this.featureName,this.ee)})),this.ee.buffer([et,rt,"xhr-resolved"],this.featureName),u.buffer([et],this.featureName),s.buffer(["setTimeout"+Ye,"clearTimeout"+Ze,et],this.featureName),c.buffer([et,"new-xhr","send-xhr"+Ze],this.featureName),d.buffer([$e+Ze,$e+"-done",$e+Xe+Ze,$e+Xe+Ye],this.featureName),l.buffer(["newURL"],this.featureName),f.buffer([et],this.featureName),a.buffer(["propagate",tt,Je,"executor-err","resolve"+Ze],this.featureName),i.buffer([et,"no-"+et],this.featureName),o.buffer(["new-jsonp","cb-start","jsonp-error","jsonp-end"],this.featureName),v(d,$e+Ze),v(d,$e+"-done"),v(o,"new-jsonp"),v(o,"jsonp-end"),v(o,"cb-start"),l.on("pushState-end",h),l.on("replaceState-end",h),window.addEventListener("hashchange",h,(0,A.jT)(!0,this.removeOnAbort?.signal)),window.addEventListener("load",h,(0,A.jT)(!0,this.removeOnAbort?.signal)),window.addEventListener("popstate",(function(){h(0,n>1)}),(0,A.jT)(!0,this.removeOnAbort?.signal)),this.abortHandler=this.#n,this.importAggregator(e)}#n(){this.removeOnAbort?.abort(),this.abortHandler=void 0}}var it=i(3333);class ot extends b{static featureName=it.TZ;constructor(e,t=!0){super(e,it.TZ,t);const r=[e.init.page_action.enabled,e.init.performance.capture_marks,e.init.performance.capture_measures,e.init.user_actions.enabled];p.RI&&e.init.user_actions.enabled&&(it.Zp.forEach((e=>(0,A.sp)(e,(e=>(0,x.p)("ua",[e],void 0,this.featureName,this.ee)),!0))),it.qN.forEach((e=>(0,A.sp)(e,(e=>(0,x.p)("ua",[e],void 0,this.featureName,this.ee)))))),r.some((e=>e))?this.importAggregator(e):this.deregisterDrain()}}var at=i(993),st=i(3785);class ct extends b{static featureName=at.TZ;constructor(e,t=!0){super(e,at.TZ,t);const r=this.ee;this.ee.on("wrap-logger-end",(function([e]){const{level:t,customAttributes:n}=this;(0,st.R)(r,e,n,t)})),this.importAggregator(e)}}new class extends o{constructor(t,r){super(r),p.gm?(this.features={},(0,R.bQ)(this.agentIdentifier,this),this.desiredFeatures=new Set(t.features||[]),this.desiredFeatures.add(w),this.runSoftNavOverSpa=[...this.desiredFeatures].some((e=>e.featureName===a.K7.softNav)),(0,d.j)(this,t,t.loaderType||"agent"),this.run()):(0,e.R)(21)}get config(){return{info:this.info,init:this.init,loader_config:this.loader_config,runtime:this.runtime}}run(){try{const t=u(this.agentIdentifier),r=[...this.desiredFeatures];r.sort(((e,t)=>a.P3[e.featureName]-a.P3[t.featureName])),r.forEach((r=>{if(!t[r.featureName]&&r.featureName!==a.K7.pageViewEvent)return;if(this.runSoftNavOverSpa&&r.featureName===a.K7.spa)return;if(!this.runSoftNavOverSpa&&r.featureName===a.K7.softNav)return;const n=function(e){switch(e){case a.K7.ajax:return[a.K7.jserrors];case a.K7.sessionTrace:return[a.K7.ajax,a.K7.pageViewEvent];case a.K7.sessionReplay:return[a.K7.sessionTrace];case a.K7.pageViewTiming:return[a.K7.pageViewEvent];default:return[]}}(r.featureName).filter((e=>!(e in this.features)));n.length>0&&(0,e.R)(36,{targetFeature:r.featureName,missingDependencies:n}),this.features[r.featureName]=new r(this)}))}catch(t){(0,e.R)(22,t);for(const e in this.features)this.features[e].abortHandler?.();const r=(0,R.Zm)();delete r.initializedAgents[this.agentIdentifier]?.api,delete r.initializedAgents[this.agentIdentifier]?.features,delete this.sharedAggregator;return r.ee.get(this.agentIdentifier).abort(),!1}}}({features:[he,w,N,Ne,_e,_,D,ot,ct,je,nt],loaderType:"spa"})})()})();</script> <meta name="viewport" content="width=device-width, initial-scale=1" /> <meta name="format-detection" content="telephone=no" /> <link rel="dns-prefetch" href="//www.rsc-cdn.org"> <link rel="dns-prefetch" href="//www.googletagmanager.com"> <link rel="dns-prefetch" href="//www.google-analytics.com"> <link rel="apple-touch-icon" sizes="180x180" href="/apple-touch-icon.png"> <link rel="icon" type="image/png" sizes="32x32" href="/favicon-32x32.png"> <link rel="icon" type="image/png" sizes="16x16" href="/favicon-16x16.png"> <link rel="manifest" href="/site.webmanifest"> <link rel="mask-icon" href="/safari-pinned-tab.svg" color="#5bbad5"> <meta name="msapplication-TileColor" content="#2d89ef"> <meta name="theme-color" content="#ffffff">  <link href="https://www.rsc-cdn.org/oxygen/assets/webfonts/fonts.min.css" rel="stylesheet" type="text/css" /> <link href="https://www.rsc-cdn.org/pubs-core/2022.0.159/content/stylesheets/pubs-ui.min.css" rel="stylesheet" type="text/css" /> <meta name="dc.domain" content="pdf" /> <script type="application/ld+json"> { "@context": "https://schema.org", "@type": "ScholarlyArticle", "publisher": { "@type": "Organization", "name": "The Royal Society of Chemistry" }, "mainEntityOfPage": { "@type": "WebPage", "@id": "https://pubs.rsc.org/en/content/articlelanding/2014/py/c3py01634j" }, "headline": "In situ forming biodegradable electroactive hydrogels", "image": "https://pubs.rsc.org/en/Content/Image/GA/C3PY01634J", "isAccessibleForFree": "False", "hasPart": { "@type": "WebPageElement", "isAccessibleForFree": "False", "cssSelector": ".t-html" } } </script> <meta name="twitter:card" content="summary_large_image" /> <meta name="twitter:site" content="@polymchem" /> <meta property="og:url" content="https://pubs.rsc.org/en/content/articlelanding/2014/py/c3py01634j" /> <meta property="og:type" content="Article" /> <meta property="og:title" content="In situ forming biodegradable electroactive hydrogels" /> <meta property="og:image" content="https://pubs.rsc.org/en/Content/Image/GA/C3PY01634J" /> <meta property="og:description" content="Electroactive injectable degradable hydrogels have great potential as bioactive scaffolds for tissue regeneration. We present the development of a series of in situ forming biodegradable electroactive hydrogels which were synthesized by in situ crosslinking of gelatin-graft-polyaniline (GP) by genipin at bod" /> <link rel="canonical" href="https://pubs.rsc.org/en/content/articlelanding/2014/py/c3py01634j" /> <meta name="DC.Creator" content="Longchao Li" /> <meta content="Longchao Li" name="citation_author" /><meta content="Center for Biomedical Engineering and Regenerative Medicine, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, China" name="citation_author_institution" /> <meta name="DC.Creator" content="Juan Ge" /> <meta content="Juan Ge" name="citation_author" /><meta content="Center for Biomedical Engineering and Regenerative Medicine, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, China" name="citation_author_institution" /> <meta name="DC.Creator" content="Baolin Guo" /> <meta content="Baolin Guo" name="citation_author" /><meta content="Center for Biomedical Engineering and Regenerative Medicine, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, China" name="citation_author_institution" /> <meta name="DC.Creator" content="Peter X. Ma" /> <meta content="Peter X. Ma" name="citation_author" /><meta content="Center for Biomedical Engineering and Regenerative Medicine, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, China" name="citation_author_institution" /><meta content="Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA" name="citation_author_institution" /><meta content="Department of Biologic and Materials Sciences, University of Michigan, 1011, North University Ave., Room 2209, Ann Arbor, MI 48109, USA" name="citation_author_institution" /><meta content="Macromolecular Science and Engineering Center, University of Michigan, Ann Arbor, MI 48109, USA" name="citation_author_institution" /><meta content="Department of Materials Science and Engineering, University of Michigan, Ann Arbor, MI 48109, USA" name="citation_author_institution" /><meta name="DC.title" content="In situ forming biodegradable electroactive hydrogels" /> <meta name="DC.publisher" content="The Royal Society of Chemistry" /> <meta name="DC.issued" content="2013/12/20" /> <meta name="DC.Identifier" content="10.1039/C3PY01634J" /> <meta name="DC.Language" content="en" /> <meta name="PPL.DocType" content="journals" /> <meta name="description" content="Electroactive injectable degradable hydrogels have great potential as bioactive scaffolds for tissue regeneration. We present the development of a series of in situ forming biodegradable electroactive hydrogels which were synthesized by in situ crosslinking of gelatin-graft-polyaniline (GP) by genipin at bod " /> <meta content="1759-9962" name="citation_issn" /> <meta content="In situ forming biodegradable electroactive hydrogels" name="citation_title" /> <meta content="2013/12/20" name="citation_online_date" /><meta content="2014/03/19" name="citation_publication_date" /> <meta content="Polymer Chemistry" name="citation_journal_title" /> <meta content="5" name="citation_volume" /> <meta content="8" name="citation_issue" /> <meta content="2880" name="citation_firstpage" /> <meta content="2890" name="citation_lastpage" /> <meta content="10.1039/C3PY01634J" name="citation_doi" /> <meta content="https://pubs.rsc.org/en/content/articlepdf/2014/py/c3py01634j" name="citation_pdf_url" /> <meta content="https://pubs.rsc.org/en/content/articlelanding/2014/py/c3py01634j" name="citation_abstract_html_url" /> <meta content="https://pubs.rsc.org/en/content/articlehtml/2014/py/c3py01634j" name="citation_fulltext_html_url" /> <meta content="Polym. Chem." name="citation_journal_abbrev" /> <meta name="keywords" content="" /> <meta name="citation_reference" content="citation_author=D. Y. Ko; citation_author=U. P. Shinde; citation_author=B. Yeon; citation_author=B. Jeong; citation_journal_title=Prog. Polym. Sci.; citation_volume=38; citation_pages=672-701;citation_publication_date=2013; " /> <meta name="citation_reference" content="citation_author=Y. L. Li; citation_author=J. Rodrigues; citation_author=H. Tomas; citation_journal_title=Chem. Soc. Rev.; citation_volume=41; citation_pages=2193-2221;citation_publication_date=2012; " /> <meta name="citation_reference" content="citation_author=L. Yu; citation_author=J. D. Ding; citation_journal_title=Chem. Soc. Rev.; citation_volume=37; citation_pages=1473-1481;citation_publication_date=2008; " /> <meta name="citation_reference" content="citation_author=H. Shin; citation_author=S. Jo; citation_author=A. G. Mikos; citation_journal_title=Biomaterials; citation_volume=24; citation_pages=4353-4364;citation_publication_date=2003; " /> <meta name="citation_reference" content="citation_author=M. P. Lutolf; citation_author=J. A. Hubbell; citation_journal_title=Nat. Biotechnol.; citation_volume=23; citation_pages=47-55;citation_publication_date=2005; " /> <meta name="citation_reference" content="citation_author=P. X. Ma; citation_journal_title=Adv. Drug Delivery Rev.; citation_volume=60; citation_pages=184-198;citation_publication_date=2008; " /> <meta name="citation_reference" content="citation_author=N. de Jonge; citation_author=F. M. W. Kanters; citation_author=F. P. T. Baaijens; citation_author=C. V. C. Bouten; citation_journal_title=Ann. Biomed. Eng.; citation_volume=41; citation_pages=763-774;citation_publication_date=2013; " /> <meta name="citation_reference" content="citation_author=S. H. Lu; citation_author=Q. X. Lin; citation_author=Y. N. Liu; citation_author=Q. Gao; citation_author=T. Hao; citation_author=Y. Wang; citation_author=J. Zhou; citation_author=H. B. Wang; citation_author=Z. Y. Du; citation_author=J. Wu; citation_author=C. Y. Wang; citation_journal_title=J. Tissue Eng. Regener. Med.; citation_volume=6; citation_pages=786-792;citation_publication_date=2012; " /> <meta name="citation_reference" content="citation_author=J. Rnjak-Kovacina; citation_author=S. G. Wise; citation_author=Z. Li; citation_author=P. K. M. Maitz; citation_author=C. J. Young; citation_author=Y. W. Wang; citation_author=A. S. Weiss; citation_journal_title=Acta Biomater.; citation_volume=8; citation_pages=3714-3722;citation_publication_date=2012; " /> <meta name="citation_reference" content="citation_author=S. Das; citation_author=F. Pati; citation_author=S. Chameettachal; citation_author=S. Pahwa; citation_author=A. R. Ray; citation_author=S. Dhara; citation_author=S. Ghosh; citation_journal_title=Biomacromolecules; citation_volume=14; citation_pages=311-321;citation_publication_date=2013; " /> <meta name="citation_reference" content="citation_author=S. Pok; citation_author=J. D. Myers; citation_author=S. V. Madihally; citation_author=J. G. Jacot; citation_journal_title=Acta Biomater.; citation_volume=9; citation_pages=5630-5642;citation_publication_date=2013; " /> <meta name="citation_reference" content="citation_author=H. W. Kang; citation_author=Y. Tabata; citation_author=Y. Ikada; citation_journal_title=Biomaterials; citation_volume=20; citation_pages=1339-1344;citation_publication_date=1999; " /> <meta name="citation_reference" content="citation_author=L. Ghasemi-Mobarakeh; citation_author=M. P. Prabhakaran; citation_author=M. Morshed; citation_author=M. H. Nasr-Esfahani; citation_author=S. Ramakrishna; citation_journal_title=Biomaterials; citation_volume=29; citation_pages=4532-4539;citation_publication_date=2008; " /> <meta name="citation_reference" content="citation_author=X. Liu; citation_author=L. A. Smith; citation_author=J. Hu; citation_author=P. X. Ma; citation_journal_title=Biomaterials; citation_volume=30; citation_pages=2252-2258;citation_publication_date=2009; " /> <meta name="citation_reference" content="citation_author=Y. C. Chen; citation_author=W. Y. Su; citation_author=S. H. Yang; citation_author=A. Gefen; citation_author=F. H. Lin; citation_journal_title=Acta Biomater.; citation_volume=9; citation_pages=5181-5193;citation_publication_date=2013; " /> <meta name="citation_reference" content="citation_author=J. Gil-Albarova; citation_author=M. Vila; citation_author=J. Badiola-Vargas; citation_author=S. Sanchez-Salcedo; citation_author=A. Herrera; citation_author=M. Vallet-Regi; citation_journal_title=Acta Biomater.; citation_volume=8; citation_pages=3777-3783;citation_publication_date=2012; " /> <meta name="citation_reference" content="citation_author=J. X. Xue; citation_author=B. Feng; citation_author=R. Zheng; citation_author=Y. Lu; citation_author=G. D. Zhou; citation_author=W. Liu; citation_author=Y. L. Cao; citation_author=Y. Z. Zhang; citation_author=W. J. Zhang; citation_journal_title=Biomaterials; citation_volume=34; citation_pages=2624-2631;citation_publication_date=2013; " /> <meta name="citation_reference" content="citation_author=H. W. Kim; citation_author=J. H. Song; citation_author=H. E. Kim; citation_journal_title=Adv. Funct. Mater.; citation_volume=15; citation_pages=1988-1994;citation_publication_date=2005; " /> <meta name="citation_reference" content="citation_author=Y. Tabata; citation_author=Y. Ikada; citation_journal_title=Adv. Drug Delivery Rev.; citation_volume=31; citation_pages=287-301;citation_publication_date=1998; " /> <meta name="citation_reference" content="citation_author=X. H. Liu; citation_author=P. X. Ma; citation_journal_title=Biomaterials; citation_volume=30; citation_pages=4094-4103;citation_publication_date=2009; " /> <meta name="citation_reference" content="citation_author=D. M. Kirchmajer; citation_author=C. A. Watson; citation_author=M. Ranson; citation_author=M. I. H. Panhuis; citation_journal_title=RSC Adv.; citation_volume=3; citation_pages=1073-1081;citation_publication_date=2013; " /> <meta name="citation_reference" content="citation_author=M. E. Frohbergh; citation_author=A. Katsman; citation_author=G. R. Botta; citation_author=P. Lazarovici; citation_author=C. L. Schauer; citation_author=U. G. K. Wegst; citation_author=P. I. Lelkes; citation_journal_title=Biomaterials; citation_volume=33; citation_pages=9167-9178;citation_publication_date=2012; " /> <meta name="citation_reference" content="citation_author=M. C. Chen; citation_author=C. T. Liu; citation_author=H. W. Tsai; citation_author=W. Y. Lai; citation_author=Y. Chang; citation_author=H. W. Sung; citation_journal_title=Biomaterials; citation_volume=30; citation_pages=5560-5571;citation_publication_date=2009; " /> <meta name="citation_reference" content="citation_author=R. A. A. Muzzarelli; citation_journal_title=Carbohydr. Polym.; citation_volume=77; citation_pages=1-9;citation_publication_date=2009; " /> <meta name="citation_reference" content="citation_author=M. S. Kim; citation_author=I. Jun; citation_author=Y. M. Shin; citation_author=W. Jang; citation_author=S. I. Kim; citation_author=H. Shin; citation_journal_title=Macromol. Biosci.; citation_volume=10; citation_pages=91-100;citation_publication_date=2010; " /> <meta name="citation_reference" content="citation_author=S. Panzavolta; citation_author=M. Gioffre; citation_author=M. L. Focarete; citation_author=C. Gualandi; citation_author=L. Foroni; citation_author=A. Bigi; citation_journal_title=Acta Biomater.; citation_volume=7; citation_pages=1702-1709;citation_publication_date=2011; " /> <meta name="citation_reference" content="citation_author=Y. S. Chen; citation_author=J. Y. Chang; citation_author=C. Y. Cheng; citation_author=F. J. Tsai; citation_author=C. H. Yao; citation_author=B. S. Liu; citation_journal_title=Biomaterials; citation_volume=26; citation_pages=3911-3918;citation_publication_date=2005; " /> <meta name="citation_reference" content="citation_author=B. L. Guo; citation_author=A. Finne-Wistrand; citation_author=A. C. Albertsson; citation_journal_title=Prog. Polym. Sci.; citation_volume=38; citation_pages=1263-1286;citation_publication_date=2013; " /> <meta name="citation_reference" content="citation_author=N. K. Guimard; citation_author=N. Gomez; citation_author=C. E. Schmidt; citation_journal_title=Prog. Polym. Sci.; citation_volume=32; citation_pages=876-921;citation_publication_date=2007; " /> <meta name="citation_reference" content="citation_author=M. M. Perez-Madrigal; citation_author=E. Armelin; citation_author=L. J. del Valle; citation_author=F. Estrany; citation_author=C. Aleman; citation_journal_title=Polym. Chem.; citation_volume=3; citation_pages=979-991;citation_publication_date=2012; " /> <meta name="citation_reference" content="citation_author=J. Y. Lee; citation_author=C. A. Bashur; citation_author=A. S. Goldstein; citation_author=C. E. Schmidt; citation_journal_title=Biomaterials; citation_volume=30; citation_pages=4325-4335;citation_publication_date=2009; " /> <meta name="citation_reference" content="citation_author=J. W. Xie; citation_author=M. R. MacEwan; citation_author=S. M. Willerth; citation_author=X. R. Li; citation_author=D. W. Moran; citation_author=S. E. Sakiyama-Elbert; citation_author=Y. N. Xia; citation_journal_title=Adv. Funct. Mater.; citation_volume=19; citation_pages=2312-2318;citation_publication_date=2009; " /> <meta name="citation_reference" content="citation_author=M. Y. Li; citation_author=Y. Guo; citation_author=Y. Wei; citation_author=A. G. MacDiarmid; citation_author=P. I. Lelkes; citation_journal_title=Biomaterials; citation_volume=27; citation_pages=2705-2715;citation_publication_date=2006; " /> <meta name="citation_reference" content="citation_author=M. R. Abidian; citation_author=K. A. Ludwig; citation_author=T. C. Marzullo; citation_author=D. C. Martin; citation_author=D. R. Kipke; citation_journal_title=Adv. Mater.; citation_volume=21; citation_pages=3764-3770;citation_publication_date=2009; " /> <meta name="citation_reference" content="citation_author=M. R. Abidian; citation_author=D. H. Kim; citation_author=D. C. Martin; citation_journal_title=Adv. Mater.; citation_volume=18; citation_pages=405-409;citation_publication_date=2006; " /> <meta name="citation_reference" content="citation_author=M. R. Abidian; citation_author=J. M. Corey; citation_author=D. R. Kipke; citation_author=D. C. Martin; citation_journal_title=Small; citation_volume=6; citation_pages=421-429;citation_publication_date=2010; " /> <meta name="citation_reference" content="citation_author=M. R. Abidian; citation_author=E. D. Daneshvar; citation_author=B. M. Egeland; citation_author=D. R. Kipke; citation_author=P. S. Cederna; citation_author=M. G. Urbanchek; citation_journal_title=Adv. Healthcare Mater.; citation_volume=1; citation_pages=762-767;citation_publication_date=2012; " /> <meta name="citation_reference" content="citation_author=B. L. Guo; citation_author=A. Finne-Wistrand; citation_author=A. C. Albertsson; citation_journal_title=Macromolecules; citation_volume=45; citation_pages=652-659;citation_publication_date=2012; " /> <meta name="citation_reference" content="citation_author=B. L. Guo; citation_author=A. Finne-Wistrand; citation_author=A. C. Albertsson; citation_journal_title=Macromolecules; citation_volume=44; citation_pages=5227-5236;citation_publication_date=2011; " /> <meta name="citation_reference" content="citation_author=B. L. Guo; citation_author=A. Finne-Wistrand; citation_author=A. C. Albertsson; citation_journal_title=Chem. Mater.; citation_volume=23; citation_pages=4045-4055;citation_publication_date=2011; " /> <meta name="citation_reference" content="citation_author=B. L. Guo; citation_author=A. Finne-Wistrand; citation_author=A. C. Albertsson; citation_journal_title=Chem. Mater.; citation_volume=23; citation_pages=1254-1262;citation_publication_date=2011; " /> <meta name="citation_reference" content="citation_author=B. L. Guo; citation_author=A. Finne-Wistrand; citation_author=A. C. Albertsson; citation_journal_title=J. Polym. Sci., Part A: Polym. Chem.; citation_volume=49; citation_pages=2097-2105;citation_publication_date=2011; " /> <meta name="citation_reference" content="citation_author=B. L. Guo; citation_author=A. Finne-Wistrand; citation_author=A. C. Albertsson; citation_journal_title=Biomacromolecules; citation_volume=12; citation_pages=2601-2609;citation_publication_date=2011; " /> <meta name="citation_reference" content="citation_author=B. L. Guo; citation_author=Y. Sun; citation_author=A. Finne-Wistrand; citation_author=K. Mustafa; citation_author=A. C. Albertsson; citation_journal_title=Acta Biomater.; citation_volume=8; citation_pages=144-153;citation_publication_date=2012; " /> <meta name="citation_reference" content="citation_author=D. Mawad; citation_author=E. Stewart; citation_author=D. L. Officer; citation_author=T. Romeo; citation_author=P. Wagner; citation_author=K. Wagner; citation_author=G. G. Wallace; citation_journal_title=Adv. Funct. Mater.; citation_volume=22; citation_pages=2692-2699;citation_publication_date=2012; " /> <meta name="citation_reference" content="citation_author=S. Bhadra; citation_author=D. Khastgir; citation_author=N. K. Singha; citation_author=J. H. Lee; citation_journal_title=Prog. Polym. Sci.; citation_volume=34; citation_pages=783-810;citation_publication_date=2009; " /> <meta name="citation_reference" content="citation_author=X. Wang; citation_author=T. L. Sun; citation_author=C. Y. Wang; citation_author=C. Wang; citation_author=W. J. Zhang; citation_author=Y. Wei; citation_journal_title=Macromol. Chem. Phys.; citation_volume=211; citation_pages=1814-1819;citation_publication_date=2010; " /> <meta name="citation_reference" content="citation_author=C. H. Luo; citation_author=H. Peng; citation_author=L. J. Zhang; citation_author=G. L. Lu; citation_author=Y. T. Wang; citation_author=J. Travas-Sejdic; citation_journal_title=Macromolecules; citation_volume=44; citation_pages=6899-6907;citation_publication_date=2011; " /> <meta name="citation_reference" content="citation_author=S. Pruneanu; citation_author=E. Veress; citation_author=I. Marian; citation_author=L. Oniciu; citation_journal_title=J. Mater. Sci.; citation_volume=34; citation_pages=2733-2739;citation_publication_date=1999; " /> <meta name="citation_reference" content="citation_author=M. F. Butler; citation_author=Y. F. Ng; citation_author=P. D. A. Pudney; citation_journal_title=J. Polym. Sci., Part A: Polym. Chem.; citation_volume=41; citation_pages=3941-3953;citation_publication_date=2003; " /> <meta name="citation_reference" content="citation_author=Z. W. Ma; citation_author=C. Y. Gao; citation_author=Y. H. Gong; citation_author=J. C. Shen; citation_journal_title=Biomaterials; citation_volume=26; citation_pages=1253-1259;citation_publication_date=2005; " /> <meta name="citation_reference" content="citation_author=T. Jana; citation_author=A. K. Nandi; citation_journal_title=Langmuir; citation_volume=17; citation_pages=5768-5774;citation_publication_date=2001; " /> <meta name="citation_reference" content="citation_author=Y. Y. Xia; citation_author=H. L. Zhu; citation_journal_title=Soft Matter; citation_volume=7; citation_pages=9388-9393;citation_publication_date=2011; " /> <meta name="citation_reference" content="citation_author=L. H. Huang; citation_author=X. L. Zhuang; citation_author=J. Hu; citation_author=L. Lang; citation_author=P. B. Zhang; citation_author=Y. S. Wang; citation_author=X. S. Chen; citation_author=Y. Wei; citation_author=X. B. Jing; citation_journal_title=Biomacromolecules; citation_volume=9; citation_pages=850-858;citation_publication_date=2008; " /> <meta name="citation_reference" content="citation_author=G. B. Wei; citation_author=Q. M. Jin; citation_author=W. V. Giannobile; citation_author=P. X. Ma; citation_journal_title=J. Controlled Release; citation_volume=112; citation_pages=103-110;citation_publication_date=2006; " /> <meta name="citation_reference" content="citation_author=A. E. van der Ende; citation_author=V. Sathiyakumar; citation_author=R. Diaz; citation_author=D. E. Hallahan; citation_author=E. Harth; citation_journal_title=Polym. Chem.; citation_volume=1; citation_pages=93-96;citation_publication_date=2010; " /> <meta name="citation_reference" content="citation_author=M. C. Klak; citation_author=E. Lefebvre; citation_author=L. Remy; citation_author=R. Agniel; citation_author=J. Picard; citation_author=S. Giraudier; citation_author=V. Larreta-Garde; citation_journal_title=Macromol. Biosci.; citation_volume=13; citation_pages=687-695;citation_publication_date=2013; " /> <meta name="citation_reference" content="citation_author=H. Bagheri; citation_author=Z. Ayazi; citation_author=M. Naderi; citation_journal_title=Anal. Chim. Acta; citation_volume=767; citation_pages=1-13;citation_publication_date=2013; " /> <meta name="citation_reference" content="citation_author=P. Niemeyer; citation_author=K. Fechner; citation_author=S. Milz; citation_author=W. Richter; citation_author=N. P. Suedkamp; citation_author=A. T. Mehlhorn; citation_author=S. Pearce; citation_author=P. Kasten; citation_journal_title=Biomaterials; citation_volume=31; citation_pages=3572-3579;citation_publication_date=2010; " /> <meta name="citation_reference" content="citation_author=H. Tian; citation_author=S. Bharadwaj; citation_author=Y. Liu; citation_author=H. Y. Ma; citation_author=P. X. Ma; citation_author=A. Atala; citation_author=Y. Y. Zhang; citation_journal_title=Biomaterials; citation_volume=31; citation_pages=870-877;citation_publication_date=2010; " /> <meta name="citation_reference" content="citation_author=M. C. Chen; citation_author=Y. C. Sun; citation_author=Y. H. Chen; citation_journal_title=Acta Biomater.; citation_volume=9; citation_pages=5562-5572;citation_publication_date=2013; " /> <meta name="citation_reference" content="citation_author=H. Kaji; citation_author=T. Ishibashi; citation_author=K. Nagamine; citation_author=M. Kanzaki; citation_author=M. Nishizawa; citation_journal_title=Biomaterials; citation_volume=31; citation_pages=6981-6986;citation_publication_date=2010; " /> <meta content=" Electroactive injectable degradable hydrogels have great potential as bioactive scaffolds for tissue regeneration. We present the development of a series of in situ forming biodegradable electroactive hydrogels which were synthesized by in situ crosslinking of gelatin-graft-polyaniline (GP) by genipin at body temperature. The chemical structure and electroactivity of the GP co-polymers was confirmed. The formation of in situ hydrogels was demonstrated by the test tube inversion method and rheology measurement. Gelation time, swelling ratio and degradation rate of the hydrogels were controlled by the polyaniline content and genipin content. The conductivity of the hydrogels in the swollen state increased with increasing the polyaniline content in the materials. Interestingly, the hydrogels exhibited a linear release profile of in situ encapsulated diclofenac sodium. The non-cytotoxicity of the hydrogels was confirmed via cell adhesion and proliferation by using bone marrow mesenchymal stem cells and rat C2C12 myoblast cells. These in situ formed degradable electroactive hydrogels represent a new class of biomaterials and as biomimetic scaffolds they have great potential for sophisticated tissue engineering, such as bone, muscle and neural regeneration. " name="citation_abstract" /> <meta name="fragment" content="!" />  <script type="text/javascript" src="https://cdn-ukwest.onetrust.com/consent/4858ece2-d985-4da2-982d-42219fead606/OtAutoBlock.js"></script> <script src="https://cdn-ukwest.onetrust.com/scripttemplates/otSDKStub.js" type="text/javascript" charset="UTF-8" data-domain-script="4858ece2-d985-4da2-982d-42219fead606"></script> <script type="text/javascript"> function OptanonWrapper() { } </script>   <script>(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer','GTM-5HVSFVCN');</script>  </head> <body id="pagetop" class="oxy-ui pubs-ui alp-page ">  <noscript> <iframe src="//www.googletagmanager.com/ns.html?id=GTM-5HVSFVCN" height="0" width="0" style="display:none;visibility:hidden"></iframe> </noscript>  <div data-id="pnlAccSkipLinks" class="skipto-control"> <a href="#maincontent" class="skipto__link"> <div class="viewport r-gutter"> Jump to main content <img src="https://www.rsc-cdn.org/oxygen/assets/icons/arrow-right-o-light.png" width="24" class="ver-m" alt=""> </div> </a> <a href="#SearchText" class="skipto__link"> <div class="viewport r-gutter"> Jump to site search <img src="https://www.rsc-cdn.org/oxygen/assets/icons/arrow-right-o-light.png" width="24" class="ver-m" alt=""> </div> </a> </div> <header role="banner" data-id="pnlGlobalHeader" class="pubs-header"> <div class="viewport"> <div class="pubs-header__wrapper"> <div class="pubs-header__cell pubs-header__cell--menu"> <a href="#" role="button" id="btnHamburgerMainNav" class="pubs-header__btn pubs-header__btn--open" aria-label="Open site menu"><img src="https://www.rsc-cdn.org/oxygen/assets/icons/menu-light.png" width="24" alt=""></a> </div> <div class="pubs-header__cell pubs-header__cell--home"> <a href="/" class="pubs-header__link pubs-header__link--home" title="Publishing home page" aria-label="Publishing home page">Publishing</a> </div> <div class="pubs-header__cell pubs-header__cell--nav"> <nav class="pubs-header__nav"> <ul> <li class="pubs-header__nav-item"><a href="/en/journals?key=title&value=current" class="pubs-header__link" target="_self">Journals</a></li> <li class="pubs-header__nav-item"><a href="https://books.rsc.org/books/search-results?fl_SiteID=5&page=1&f_ContentType=Book&sort=Date+-+Newest+First" class="pubs-header__link" target="_blank">Books</a></li> <li class="pubs-header__nav-item"><a href="https://www.rsc.org/journals-books-databases/databases-literature-updates/" class="pubs-header__link" target="_blank">Databases</a></li> </ul> </nav> </div> <div class="pubs-header__cell pubs-header__cell--search-mobile"> <a href="#" class="pubs-header__btn" aria-label="Search" id="mobileSearchTrigger"><img src="https://www.rsc-cdn.org/oxygen/assets/icons/search-light.png" width="24" alt="" id="mobileSearchIcon"></a> </div> <div class="pubs-header__cell pubs-header__cell--search"> <div class="pubs-search-control"> <form action="/en/results" aria-label="Sitewide" id="SimpleSearch-form" method="post" role="search"> <label for="SearchText" class="sr-only">Search</label> <input autocomplete="off" class="pubs-search__input" id="SearchText" name="SearchText" type="search" value="" /> <div class="pubs-search__actions"> <button class="input__search-submit" type="submit" aria-label="Search" id="btnNavSearchInput"><img src="https://www.rsc-cdn.org/oxygen/assets/icons/arrow-right.png" width="32" alt=""></button> <a class="pubs-search__adv-link" href="/en/search/advancedsearch" aria-label="Advanced search" id="advancedLink">Advanced</a> </div> <span class="pubs-search__icon"></span> </form> </div> </div> <div class="pubs-header__cell pubs-header__cell--login"> <a href="/en/account/logon" class="pubs-header__btn" aria-label="Log in or register"><img src="https://www.rsc-cdn.org/oxygen/assets/icons/user-light.png" width="24" alt="" id="userIcon"></a> </div> <div class="pubs-header__cell pubs-header__cell--trolley"> <a href="https://www.rsc.org/basket/shoppingcart/orderitems?returnurl=https://pubs.rsc.org/en/content/articlelanding/2014/py/c3py01634j" class="pubs-header__btn" aria-label="View your basket"><img src="https://www.rsc-cdn.org/oxygen/assets/icons/trolley-light.png" width="24" alt="" id="trolleyIcon"></a> <span class="badge badge--count" style="display: none;"></span> </div> <div class="pubs-header__cell pubs-header__cell--logo"> <a href="https://www.rsc.org" class=""><img src="https://www.rsc-cdn.org/pubs-core/2022.0.159/content/NewImages/rsc-logo-rev-pubs.svg" height="40" alt="Royal Society of Chemistry homepage"></a> </div> </div> </div> <div class="mobile-search" id="mobileSearchPanel"> <div class="viewport"> <div class=""> <div class="autopad--h fixpadt--l"> <form action="/en/results" aria-label="Sitewide" id="SimpleSearch-formMobile" method="post" role="search"> <label for="SearchTextMobile" class="sr-only">Search</label> <div class="input__search"> <i class="icon--search"></i> <input autocomplete="off" placeholder="Search term, doi, title, author" type="search" class="input__field input__field--basic input__label--block" id="SearchTextMobile" name="SearchText"> <button class="input__search-submit" name="search" type="submit" aria-label="Search"> <img src="https://www.rsc-cdn.org/oxygen/assets/icons/arrow-right.png" width="32" alt="" class="input__submit-icon"> </button> </div> <div class="input--error" id="errSimpleSearchMobileText">You must enter a search term</div> <div class="fixpadv--m"> <a class="pubs-search__adv-link " href="/en/search/advancedsearch" aria-label="Advanced search" id="advancedLink">Advanced search</a> </div> </form> </div> </div> </div> </div> <div class="auth-header" data-id="pnlAuthHeader"> <div data-id="pnlSignIn"></div> <div class="viewport"> <div class="auth-header__institute-access"> <div class="auth-header__institute-messaging"> <span id="divWelcomeUser"></span> </div> </div> </div> </div> </header> <main role="main"> <noscript> <div class="viewport autopad--h fixpadb--m"> <div class="plate plate--warning"> You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our <a href="/en/home/nonjavascriptversion">non-JavaScript page</a>. </div> </div> </noscript> <div id="maincontent"> <div id="a11y-announcer" class="sr-only" aria-live="assertive" aria-atomic="true"></div> <script async src="https://securepubads.g.doubleclick.net/tag/js/gpt.js"></script> <script> var googletag = googletag || {}; googletag.cmd = googletag.cmd || []; </script> <script> googletag.cmd.push(function () { googletag.defineSlot('/97414310/pubs_journal_py_mpu_1', [300, 250], 'div-dfp-ad-1').addService(googletag.pubads()); googletag.defineSlot('/97414310/pubs_journal_py_mpu_2', [300, 250], 'div-dfp-ad-2').addService(googletag.pubads()); googletag.defineSlot('/97414310/pubs_journal_py_mpu_3', [300, 250], 'div-dfp-ad-3').addService(googletag.pubads()); googletag.pubads().enableSingleRequest(); googletag.enableServices(); }); </script> <input type="hidden" id="clicked_GetPatents" value="false" /> <input id="pageNumberTab" type="hidden" /> <input id="CitedByPN" type="hidden" /> <br> <div class="viewport"> <div class="layout-control"> <div class="layout__panel layout__panel--primary layout__panel--60 layout__panel--filled"> <section class="layout__content layout__content--padded"> <div class="article-nav"> <div class="article-nav__issue autopad--h"> <a href="/en/journals/journal/py?issueid=py005008&type=current&issnprint=1759-9954" aria-label="From Issue 8, 2014. Click to view all articles in this issue." title="Issue 8, 2014">Issue 8, 2014</a> </div> <nav aria-label="Article"> <ul class="article-nav__bar"> <li> <a href="/en/Content/ArticleLanding/2014/PY/C3PY01129A"> Previous <span class="v-mobile-hide--inline">Article</span> </a> </li> <li> <a href="/en/Content/ArticleLanding/2014/PY/C3PY01482G"> Next <span class="v-mobile-hide--inline">Article</span> </a> </li> </ul> </nav> <div class="list-control"> <div class="list__collection--image"> <div class="list__item"> <a href="/en/journals/journal/py" class="list__item-link"> <div class="list__image-col"> <img src="/en/Image/Get?imageInfo.ImageType=CoverIssue&imageInfo.ImageIdentifier.SerCode=PY&imageInfo.ImageIdentifier.IssueId=PY005008" id="imgLoader" alt="" class="list__item-img" height="88"> </div> <div class="list__text-col"> <div class="list__item-label"> <span class="page-head__context">From the journal:</span> <h3 class="h--heading3 no-heading">Polymer Chemistry</h3> </div> </div> </a> </div> </div> </div> <br> </div> <article class="article-control"> <div class="article__title"> <h2 class="capsule__title fixpadv--m"> <em>In situ</em> forming biodegradable electroactive hydrogels </h2> </div> <div class="article__authors"> <span class="article__author-link"> <a href="/en/results?searchtext=Author%3ALongchao%20Li">Longchao Li</a>,<span><sup><i>a</i></sup></span>   </span> <span class="article__author-link"> <a href="/en/results?searchtext=Author%3AJuan%20Ge">Juan Ge</a>,<span><sup><i>a</i></sup></span>   </span> <span class="article__author-link"> <a href="/en/results?searchtext=Author%3ABaolin%20Guo">Baolin Guo</a>*<span><sup><i>a</i></sup></span>  and  </span> <span class="article__author-link"> <a href="/en/results?searchtext=Author%3APeter%20X.%20Ma">Peter X. Ma</a>*<span><sup><i>abcde</i></sup></span>   </span> </div> <div class="drawer-control fixpadv--m"> <a href="#" role="button" id="btnAuthorAffiliations" aria-expanded="false" aria-controls="pnlAuthorAffiliations" class="drawer__handle"> <span class="drawer__icon"></span> Author affiliations </a> <div class="drawer__content" id="pnlAuthorAffiliations" aria-labelledby="btnAuthorAffiliations"> <div> <p class="article__author-affiliation"> <span> * </span> <span> Corresponding authors </span> </p> <p class="article__author-affiliation"> <span> <sup>a</sup> </span> <span> Center for Biomedical Engineering and Regenerative Medicine, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, China <br /> <b>E-mail:</b> <a href="mailto:baoling@mail.xjtu.edu.cn" title="baoling@mail.xjtu.edu.cn">baoling@mail.xjtu.edu.cn</a>, <a href="mailto:mapx@umich.edu" title="mapx@umich.edu">mapx@umich.edu</a> <br /> <b>Fax:</b> +86-29-83395131 <br /> <b>Tel:</b> +86-29-83395361 </span> </p> <p class="article__author-affiliation"> <span> <sup>b</sup> </span> <span> Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA </span> </p> <p class="article__author-affiliation"> <span> <sup>c</sup> </span> <span> Department of Biologic and Materials Sciences, University of Michigan, 1011, North University Ave., Room 2209, Ann Arbor, MI 48109, USA </span> </p> <p class="article__author-affiliation"> <span> <sup>d</sup> </span> <span> Macromolecular Science and Engineering Center, University of Michigan, Ann Arbor, MI 48109, USA </span> </p> <p class="article__author-affiliation"> <span> <sup>e</sup> </span> <span> Department of Materials Science and Engineering, University of Michigan, Ann Arbor, MI 48109, USA </span> </p> </div> </div> </div> <h3 class="h--heading3 article-abstract__heading">Abstract</h3> <div class="capsule__column-wrapper"> <div class="capsule__text"> <p xmlns="http://www.rsc.org/schema/rscart38">Electroactive injectable degradable hydrogels have great potential as bioactive scaffolds for tissue regeneration. We present the development of a series of <em>in situ</em> forming biodegradable electroactive hydrogels which were synthesized by <em>in situ</em> crosslinking of gelatin-<em>graft</em>-polyaniline (GP) by genipin at body temperature. The chemical structure and electroactivity of the GP co-polymers was confirmed. The formation of <em>in situ</em> hydrogels was demonstrated by the test tube inversion method and rheology measurement. Gelation time, swelling ratio and degradation rate of the hydrogels were controlled by the polyaniline content and genipin content. The conductivity of the hydrogels in the swollen state increased with increasing the polyaniline content in the materials. Interestingly, the hydrogels exhibited a linear release profile of <em>in situ</em> encapsulated diclofenac sodium. The non-cytotoxicity of the hydrogels was confirmed <em>via</em> cell adhesion and proliferation by using bone marrow mesenchymal stem cells and rat C2C12 myoblast cells. These <em>in situ</em> formed degradable electroactive hydrogels represent a new class of biomaterials and as biomimetic scaffolds they have great potential for sophisticated tissue engineering, such as bone, muscle and neural regeneration.</p> </div> <div class="capsule__article-image fixpadv--s"> <img src="/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C3PY01634J&imageInfo.ImageIdentifier.Year=2014" alt="Graphical abstract: In situ forming biodegradable electroactive hydrogels" /> </div> </div> <p></p> <div id="pnlArticleAccess" class="article-access fixpadt--xxl" style="display: none; border: 0;"> <div class="article-access__inner" style="background-color: #F1F1F3;"> <div class="article-access__head fixpad--s"> You have access to this article </div> <div class="fixpad--xl"> <div id="pnlViewFullArticleButton" class="paywall__body text--centered"> <div id="pnlArticleLoading"> <span id="thtmlLoadingMessage"> <img src="https://www.rsc-cdn.org/pubs-core/2022.0.159/content/NewImages/Ajax-GA-Loader.gif" alt="" class="ver-m" /> Please wait while we load your content... </span> <span id="thtmlErrorMessage" style="display: none;"> Something went wrong. <a href="#" id="btnTryAgain">Try again?</a> </span> </div> </div> </div> </div> </div> <div id="pnlArticleContent" class="t-html"> <div id="pnlArticleContentLoaded"> </div> </div> </article> </section> </div> <div class="layout__panel layout__panel--secondary layout__panel--40 layout__panel--filled"> <section class="layout__content"> <input id="contentType" name="contentType" type="hidden" value="" /> <div class="tab-control"> <div class="tab__nav" role="tablist" aria-label="Article"> <div class="tab__item" role="none"> <a href="#pnlAbstract" class="tab__btn selected" role="tab" id="btnAbstract" aria-selected="true" aria-controls="pnlAbstract">About</a> </div> <div class="tab__item" role="none"> <a href="#pnlCitation" class="tab__btn" role="tab" id="btnCitation" aria-selected="false" aria-controls="pnlCitation">Cited by</a> </div> <div class="tab__item" role="none"> <a href="#pnlRelatedContent" class="tab__btn" role="tab" id="btnRelatedContent" aria-selected="false" aria-controls="pnlRelatedContent">Related</a> </div> </div> <div class="tab__panel open" role="tabpanel" id="pnlAbstract" aria-hidden="false" aria-labelledby="btnAbstract" data-loaded="true"> <div class="fixpadv--m"> <div id="divAbout"> <div id="DownloadOption" class="autopad--h fixpadv--l" style="min-height: 150px;"> <div class="text--centered"> <a href="#" class="btn btn--cta btn--disabled btn--block btn--stack btn-icon btn-icon--loading"> Download options <span class="btn-info">Please wait...</span> </a> </div> </div> <div class="autopad--h"> <h2 class="h--heading3">Article information</h2> <dl class="definition-list"> <div class="c doi-link"> <dt class="sr-only">DOI</dt> <dd class="c__24"><a class="text--small" title="Link to landing page via DOI" href="https://doi.org/10.1039/C3PY01634J">https://doi.org/10.1039/C3PY01634J</a></dd> </div> <div class="c fixpadt--l line-separator"> <dt class="c__10"><strong>Article type</strong></dt> <dd class="c__14">Paper</dd> </div> <div class="c fixpadt--l"> <dt class="c__10">Submitted</dt> <dd class="c__14">24 Nov 2013</dd> </div> <div class="c fixpadt--l"> <dt class="c__10">Accepted</dt> <dd class="c__14">20 Dec 2013</dd> </div> <div class="c fixpadt--l"> <dt class="c__10">First published</dt> <dd class="c__14">20 Dec 2013</dd> </div> </dl> <div class="c fixpadt--l line-separator"> <div class="c__10"> <h3 class="definition-label"> <label for="ResultAbstractFormat"><span class="sr-only">Download</span> Citation</label> </h3> </div> <div class="c__14"> <i><strong>Polym. Chem.</strong></i>, 2014,<span style='padding-right:2px'></span><strong>5</strong>, 2880-2890 <br> <form action="/en/content/getformatedresult/c3py01634j?downloadtype=article" method="post"> <div class="select-basic"> <span> <select class="select-field" id="ResultAbstractFormat" name="ResultAbstractFormat"><option>BibTex</option> <option>EndNote</option> <option>MEDLINE</option> <option>ProCite</option> <option>ReferenceManager</option> <option>RefWorks</option> <option>RIS</option> </select> </span> <span> <input type="submit" name="go" id="Submit1" value="Go" class="btn btn--tiny" /> </span> </div> </form> </div> </div> <div class="alp-request-permissions" style="display: block;"> <div class="c fixpadt--l"> <div class="c__10"><h3 class="definition-label">Permissions</h3></div> <div class="c__14"> <a class="alp-request-permissions__open-btn" id="requestPermission" role="button" rel="license" href="#" target="_blank" aria-label="Request permissions: Click to open."> Request permissions </a> </div> </div> <div class="alp-request-permissions__content scrollbar--slim"> <a href="#" class="alp-request-permissions__close-btn btn__enter-popup" aria-label="You are in the 'Request permissions' pop up window. Click enter to close, or tab to continue."> <img src="https://www.rsc-cdn.org/oxygen/assets/icons/cross.png" class="icon" width="24" alt=""> </a> <h3 class="h--heading3"> <em>In situ</em> forming biodegradable electroactive hydrogels </h3> <p> L. Li, J. Ge, B. Guo and P. X. Ma, <i>Polym. Chem.</i>, 2014, <strong>5</strong>, 2880 <strong>DOI: </strong> 10.1039/C3PY01634J </p> <p> To request permission to reproduce material from this article, please go to the <a href="https://marketplace.copyright.com/rs-ui-web/mp/search/all/10.1039%2fC3PY01634J">Copyright Clearance Center request page</a>. </p> <p> If you are <b>an author contributing to an RSC publication, you do not need to request permission</b> provided correct acknowledgement is given. </p> <p> If you are <b>the author of this article, you do not need to request permission to reproduce figures and diagrams</b> provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the <a href="https://marketplace.copyright.com/rs-ui-web/mp/search/all/10.1039%2fC3PY01634J">Copyright Clearance Center request page</a>. </p> <p> Read more about <a href="https://www.rsc.org/journals-books-databases/journal-authors-reviewers/licences-copyright-permissions/#acknowledgements">how to correctly acknowledge RSC content</a>. </p> <a href="#" class="alp-request-permissions__close-btn btn__exit-popup" aria-label="You are at the end of the 'Request permissions' pop up window. Click enter to close, or tab to continue."><img src="https://www.rsc-cdn.org/oxygen/assets/icons/cross.png" class="icon" width="24" alt=""></a> </div> </div> <script> function downloadJSAtOnload() { var element = document.createElement("script"); element.src = "https://d1bxh8uas1mnw7.cloudfront.net/assets/altmetric_badges-8f271adb184c21cc5169a7f67f7fe5ab.js"; element.id = "altmetric-embed-js"; document.body.appendChild(element); } if (window.addEventListener) { window.addEventListener("load", downloadJSAtOnload, false); } else if (window.attachEvent) { window.attachEvent("onload", downloadJSAtOnload); } else { window.onload = downloadJSAtOnload; } </script> <div class="c fixpadv--l"> <div class="c__10"><h3 class="definition-label">Social activity</h3></div> <div class="c__14"><div data-badge-type="2" data-doi="10.1039/C3PY01634J" data-condensed="true" class="altmetric-embed"></div></div> </div> <div class="c c--gap-xs fixpadb--xl"> <div class="c__12 c--fixed"> <a class="btn btn--small btn--block btn--social btn--twitter" href="https://twitter.com/intent/tweet/?text=In+situ+forming+biodegradable+electroactive+hydrogels+-+now+published+in+Polymer+Chemistry&url=https%3a%2f%2fpubs.rsc.org%2fen%2fcontent%2farticlelanding%2f2014%2fpy%2fc3py01634j" target="_blank"> <img src="https://www.rsc-cdn.org/pubs-core/2022.0.159/content/NewImages/twitter.svg" alt="" /> <span class="ver-m">Tweet</span> </a> </div> <div class="c__12 c--fixed"> <a class="btn btn--small btn--block btn--social btn--wechat" href="/en/Image/GetQrCode?url=https%3A%2F%2Fpubs.rsc.org%2Fen%2Fcontent%2Farticlelanding%2F2014%2Fpy%2Fc3py01634j" target="_blank"> <img src="https://www.rsc-cdn.org/pubs-core/2022.0.159/content/NewImages/wechat.svg" alt="" /> <span class="ver-m">Share</span> </a> </div> </div> </div> <form action="/en/results/searchbyauthor" aria-label="Author" id="SearchByAuthor" method="post" role="search"> <div class="autopad"> <h2 class="h--heading3">Search articles by author</h2> <div class="input-group"> <div class="input__checkbox"> <input type="checkbox" id="1" data-givenname="Longchao" data-familyname="Li"> <label for="1" class="input__label">Longchao Li</label> </div> <div class="input__checkbox"> <input type="checkbox" id="2" data-givenname="Juan" data-familyname="Ge"> <label for="2" class="input__label">Juan Ge</label> </div> <div class="input__checkbox"> <input type="checkbox" id="3" data-givenname="Baolin" data-familyname="Guo"> <label for="3" class="input__label">Baolin Guo</label> </div> <div class="input__checkbox"> <input type="checkbox" id="4" data-givenname="Peter X." data-familyname="Ma"> <label for="4" class="input__label">Peter X. Ma</label> </div> </div> <input type="submit" name="go" id="Search" value="Go" title="Go" class="btn btn--tiny"> <input id="DOI" name="DOI" type="hidden" value="C3PY01634J" /> <input id="selectedAuthors" name="selectedAuthors" type="hidden" value="" /> </div> </form> <input id="authors" name="authors" type="hidden" value="<?xml version="1.0"?>
<ArrayOfAuthorInfo xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <AuthorInfo>
    <GivenName>Longchao</GivenName>
    <FirstName>Longchao</FirstName>
    <FamilyName>Li</FamilyName>
    <GivenNameNoMarkup>Longchao</GivenNameNoMarkup>
    <FirstNameNoMarkup>Longchao</FirstNameNoMarkup>
    <FamilyNameNoMarkup>Li</FamilyNameNoMarkup>
    <Type>Author</Type>
    <FirstAuthor>true</FirstAuthor>
    <Affiliation>affa</Affiliation>
    <AffiliationInfo>
      <AffiliationInfo>
        <AffiliationId>a</AffiliationId>
        <OrganisationName>Center for Biomedical Engineering and Regenerative Medicine, Frontier Institute of Science and Technology, Xi'an Jiaotong University</OrganisationName>
        <Address />
        <City>Xi'an</City>
        <State />
        <Postcode />
        <Country>China</Country>
        <Emails>
          <string>baoling@mail.xjtu.edu.cn</string>
          <string>mapx@umich.edu</string>
        </Emails>
        <Fax>+86-29-83395131</Fax>
        <Phone>+86-29-83395361</Phone>
        <Url />
        <OrganizationUrl />
      </AffiliationInfo>
    </AffiliationInfo>
    <AffiliationCodes>
      <string>a</string>
    </AffiliationCodes>
    <QualifierName />
  </AuthorInfo>
  <AuthorInfo>
    <GivenName>Juan</GivenName>
    <FirstName>Juan</FirstName>
    <FamilyName>Ge</FamilyName>
    <GivenNameNoMarkup>Juan</GivenNameNoMarkup>
    <FirstNameNoMarkup>Juan</FirstNameNoMarkup>
    <FamilyNameNoMarkup>Ge</FamilyNameNoMarkup>
    <Type>Author</Type>
    <FirstAuthor>false</FirstAuthor>
    <Affiliation>affa</Affiliation>
    <AffiliationInfo>
      <AffiliationInfo>
        <AffiliationId>a</AffiliationId>
        <OrganisationName>Center for Biomedical Engineering and Regenerative Medicine, Frontier Institute of Science and Technology, Xi'an Jiaotong University</OrganisationName>
        <Address />
        <City>Xi'an</City>
        <State />
        <Postcode />
        <Country>China</Country>
        <Emails>
          <string>baoling@mail.xjtu.edu.cn</string>
          <string>mapx@umich.edu</string>
        </Emails>
        <Fax>+86-29-83395131</Fax>
        <Phone>+86-29-83395361</Phone>
        <Url />
        <OrganizationUrl />
      </AffiliationInfo>
    </AffiliationInfo>
    <AffiliationCodes>
      <string>a</string>
    </AffiliationCodes>
    <QualifierName />
  </AuthorInfo>
  <AuthorInfo>
    <GivenName>Baolin</GivenName>
    <FirstName>Baolin</FirstName>
    <FamilyName>Guo</FamilyName>
    <GivenNameNoMarkup>Baolin</GivenNameNoMarkup>
    <FirstNameNoMarkup>Baolin</FirstNameNoMarkup>
    <FamilyNameNoMarkup>Guo</FamilyNameNoMarkup>
    <Type>Author</Type>
    <FirstAuthor>false</FirstAuthor>
    <Affiliation>affa</Affiliation>
    <AffiliationInfo>
      <AffiliationInfo>
        <AffiliationId>a</AffiliationId>
        <OrganisationName>Center for Biomedical Engineering and Regenerative Medicine, Frontier Institute of Science and Technology, Xi'an Jiaotong University</OrganisationName>
        <Address />
        <City>Xi'an</City>
        <State />
        <Postcode />
        <Country>China</Country>
        <Emails>
          <string>baoling@mail.xjtu.edu.cn</string>
          <string>mapx@umich.edu</string>
        </Emails>
        <Fax>+86-29-83395131</Fax>
        <Phone>+86-29-83395361</Phone>
        <Url />
        <OrganizationUrl />
      </AffiliationInfo>
    </AffiliationInfo>
    <Role>corres</Role>
    <AffiliationCodes>
      <string>*</string>
      <string>a</string>
    </AffiliationCodes>
    <QualifierName />
  </AuthorInfo>
  <AuthorInfo>
    <GivenName>Peter X.</GivenName>
    <FirstName>Peter X.</FirstName>
    <FamilyName>Ma</FamilyName>
    <GivenNameNoMarkup>Peter X.</GivenNameNoMarkup>
    <FirstNameNoMarkup>Peter X.</FirstNameNoMarkup>
    <FamilyNameNoMarkup>Ma</FamilyNameNoMarkup>
    <Type>Author</Type>
    <FirstAuthor>false</FirstAuthor>
    <Affiliation>affa affb affc affd affe</Affiliation>
    <AffiliationInfo>
      <AffiliationInfo>
        <AffiliationId>a</AffiliationId>
        <OrganisationName>Center for Biomedical Engineering and Regenerative Medicine, Frontier Institute of Science and Technology, Xi'an Jiaotong University</OrganisationName>
        <Address />
        <City>Xi'an</City>
        <State />
        <Postcode />
        <Country>China</Country>
        <Emails>
          <string>baoling@mail.xjtu.edu.cn</string>
          <string>mapx@umich.edu</string>
        </Emails>
        <Fax>+86-29-83395131</Fax>
        <Phone>+86-29-83395361</Phone>
        <Url />
        <OrganizationUrl />
      </AffiliationInfo>
      <AffiliationInfo>
        <AffiliationId>b</AffiliationId>
        <OrganisationName>Department of Biomedical Engineering, University of Michigan</OrganisationName>
        <Address />
        <City>Ann Arbor</City>
        <State>MI 48109</State>
        <Postcode />
        <Country>USA</Country>
        <Emails />
        <Fax />
        <Phone />
        <Url />
        <OrganizationUrl />
      </AffiliationInfo>
      <AffiliationInfo>
        <AffiliationId>c</AffiliationId>
        <OrganisationName>Department of Biologic and Materials Sciences, University of Michigan, 1011, North University Ave., Room 2209</OrganisationName>
        <Address />
        <City>Ann Arbor</City>
        <State>MI 48109</State>
        <Postcode />
        <Country>USA</Country>
        <Emails />
        <Fax />
        <Phone />
        <Url />
        <OrganizationUrl />
      </AffiliationInfo>
      <AffiliationInfo>
        <AffiliationId>d</AffiliationId>
        <OrganisationName>Macromolecular Science and Engineering Center, University of Michigan</OrganisationName>
        <Address />
        <City>Ann Arbor</City>
        <State>MI 48109</State>
        <Postcode />
        <Country>USA</Country>
        <Emails />
        <Fax />
        <Phone />
        <Url />
        <OrganizationUrl />
      </AffiliationInfo>
      <AffiliationInfo>
        <AffiliationId>e</AffiliationId>
        <OrganisationName>Department of Materials Science and Engineering, University of Michigan</OrganisationName>
        <Address />
        <City>Ann Arbor</City>
        <State>MI 48109</State>
        <Postcode />
        <Country>USA</Country>
        <Emails />
        <Fax />
        <Phone />
        <Url />
        <OrganizationUrl />
      </AffiliationInfo>
    </AffiliationInfo>
    <Role>corres</Role>
    <AffiliationCodes>
      <string>*</string>
      <string>a</string>
      <string>b</string>
      <string>c</string>
      <string>d</string>
      <string>e</string>
    </AffiliationCodes>
    <QualifierName />
  </AuthorInfo>
</ArrayOfAuthorInfo>" /> </div> </div> </div> <div class="tab__panel" role="tabpanel" id="pnlCitation" aria-hidden="true" aria-labelledby="btnCitation" data-loaded="false"> <div class="autopad--h fixpadv--m"> <div id="divCitation"> <p> <img src="https://www.rsc-cdn.org/pubs-core/2022.0.159/content/NewImages/Ajax-GA-Loader.gif" alt="" style="float:left" /> Fetching data from CrossRef.<br /> This may take some time to load. </p> </div> </div> </div> <div class="tab__panel" role="tabpanel" id="pnlRelatedContent" aria-hidden="true" aria-labelledby="btnRelatedContent" data-loaded="false"> <div class="autopad--h fixpadv--m"> <div id="divRelatedContent"> <p> <span class="sr-only">Loading related content</span> <img src="https://www.rsc-cdn.org/pubs-core/2022.0.159/content/NewImages/Ajax-GA-Loader.gif" alt="" /> </p> </div> </div> </div> </div> </section> <section class="layout__content layout__content--padded text--centered"> <h3 class="h--heading4">Spotlight</h3> <div id='div-dfp-ad-1' class="dfp-ad__slot--mpu"> <script>googletag.cmd.push(function() { googletag.display('div-dfp-ad-1'); });</script> </div> <h3 class="h--heading4">Advertisements</h3> <div id='div-dfp-ad-2' class="dfp-ad__slot--mpu"> <script>googletag.cmd.push(function() { googletag.display('div-dfp-ad-2'); });</script> </div> <div id='div-dfp-ad-3' class="dfp-ad__slot--mpu"> <script>googletag.cmd.push(function() { googletag.display('div-dfp-ad-3'); });</script> </div> </section> <section id="pbgrd-mpur-c" class="layout__content layout__content--padded text--centered"></section> </div> </div> </div> </div> </main> <div data-id="pnlGlobalFooter"> <div class="rsc-ui">  <footer class="rsc-footer"> <div class="breadcrumbs"> <div class="viewport"> <nav aria-label="Breadcrumb"> <ul> <li class="extra"><a href="https://www.rsc.org">rsc.org</a></li> <li> <img src="https://www.rsc-cdn.org/pubs-core/2022.0.159/content/NewImages/chevron-right.png" width="8" height="8" alt="" /> <a href="https://www.rsc.org/journals-books-databases/" class="selected">Journals, books & databases</a> </li> </ul> </nav> </div> </div> <div class='nav' id='pnlSiteMap'> <div class='viewport'> <div class='rsc-logo'> <img src="https://www.rsc-cdn.org/pubs-core/2022.0.159/content/NewImages/rsc-logo-rev-pubs.svg" alt="Royal Society of Chemistry homepage"> </div> <div class='links'> <ul> <li><a href='https://www.rsc.org/'>Home</a></li> <li><a href='https://www.rsc.org/about-us/'>About us</a></li> <li><a href='https://www.rsc.org/membership-and-community/'>Membership & professional community</a></li> <li><a href='https://www.rsc.org/campaigning-outreach/'>Campaigning & outreach</a></li> <li><a href='https://www.rsc.org/journals-books-databases/'>Journals, books & databases</a></li> <li><a href='https://www.rsc.org/teaching-and-learning/'>Teaching & learning</a></li> <li><a href='https://www.rsc.org/news-events/'>News & events</a></li> <li><a href='https://www.rsc.org/locations-contacts/'>Locations & contacts</a></li> <li><a href='https://www.rsc.org/careers/'>Careers</a></li> <li><a href='https://www.rsc.org/awards-funding/'>Awards & funding</a></li> <li><a href='https://www.rsc.org/advertise/'>Advertise</a></li> <li><a href='https://www.rsc.org/help-legal/'>Help & legal</a></li> <li><a href='https://www.rsc.org/help-legal/legal/privacy/'>Privacy policy</a></li> <li><a href='https://www.rsc.org/help-legal/legal/terms-conditions/'>Terms & conditions</a></li> </ul> </div> <hr class='clear'> </div> </div> <div class='baseline'> <div class='viewport'> <div class='social-icons'> <a href='https://www.facebook.com/RoyalSocietyofChemistry' class='facebook'><span class='sr-only'>Facebook</span><img src='https://www.rsc-cdn.org/pubs-core/2022.0.159/content/NewImages/facebook-128.png' height='32' width='32' alt=''></a> <a href='https://twitter.com/RoySocChem' class='twitter'><span class='sr-only'>Twitter</span><img src='https://www.rsc-cdn.org/pubs-core/2022.0.159/content/NewImages/twitter-128.png' height='32' width='32' alt=''></a> <a href='https://www.linkedin.com/company/23105' class='linkedin'><span class='sr-only'>LinkedIn</span><img src='https://www.rsc-cdn.org/pubs-core/2022.0.159/content/NewImages/linkedin-128.png' height='32' width='32' alt=''></a> <a href='https://www.youtube.com/user/wwwRSCorg' id='lastLinkOnPage' class='youtube'><span class='sr-only'>YouTube</span><img src='https://www.rsc-cdn.org/pubs-core/2022.0.159/content/NewImages/youtube-128.png' height='32' width='32' alt=''></a> </div> <div class='copyright'> © Royal Society of Chemistry 2024<br>Registered charity number: 207890 </div> </div> </div> <hr class='clear'> </footer>  <div class="rsc-onetrust-cookie-footer"> <div id="rsc-onetrust-cookie-footer-non-br">This website collects cookies to deliver a better user experience. <span id="rsc-onetrust-cookie-footer-global"> See how this site uses <a href="/en/content/cookies" title="See how this site uses cookies" aria-label="See how this site uses cookies">Cookies</a>. </span> <span id="rsc-onetrust-cookie-footer-ca" style="display: none;"> <a href="/en/content/cookies" title="Do not sell my personal data" aria-label="Do not sell my personal data">Do not sell my personal data</a>. </span> </div> <div id="rsc-onetrust-cookie-footer-br" style="display: none;"> Este site coleta cookies para oferecer uma melhor experiência ao usuário. <span> Veja como este site usa <a href="/en/content/cookies" title="Veja como este site usa cookies" aria-label="Veja como este site usa cookies">Cookies</a>. </span> </div> </div> </div> </div> <div class="modal__canvas modal__canvas--clickclose"> </div> <div class="pubs-nav-drawer" aria-hidden="true"> <nav class="pubs-nav-control" aria-label="Site menu"> <div class="pubs-nav__header"> <a href="#" role="button" class="pubs-header__btn pubs-nav__close nav-item-first" tabindex="-1" aria-label="Close site menu"><img src="https://www.rsc-cdn.org/oxygen/assets/icons/cross-light.png" width="24" alt=""></a> <a href="/" class="pubs-header__link--home pubs-nav__title" tabindex="-1" title="Publishing home page" aria-label="Publishing home page">Publishing</a> </div> <div class="pubs-nav__body scrollbar--slim"> <div class="pubs-nav__list autopad--h"> <h2 class="pubs-nav__heading">Journals</h2> <ul class="pubs-nav__ul"> <li class="pubs-nav__item pubs-nav__indent"> <a target="_self" href="/en/journals?key=title&value=current" class="pubs-nav__link" tabindex="-1">Current Journals</a> </li> <li class="pubs-nav__item pubs-nav__indent"> <a target="_self" href="/en/journals?key=title&value=archive" class="pubs-nav__link" tabindex="-1">Archive Journals</a> </li> <li class="pubs-nav__item pubs-nav__indent"> <a target="_self" href="/en/journals?key=title&value=all" class="pubs-nav__link" tabindex="-1">All Journals</a> </li> </ul> </div> <div class="pubs-nav__list autopad--h"> <h2 class="pubs-nav__heading">Books</h2> <ul class="pubs-nav__ul"> <li class="pubs-nav__item pubs-nav__indent"> <a target="_blank" href="https://books.rsc.org/books/search-results?fl_SiteID=5&page=1&f_ContentType=Book&sort=Date+-+Newest+First" class="pubs-nav__link" tabindex="-1">Browse Books</a> </li> <li class="pubs-nav__item pubs-nav__indent"> <a target="_blank" href="https://books.rsc.org/books/collections/series" class="pubs-nav__link" tabindex="-1">Series</a> </li> <li class="pubs-nav__item pubs-nav__indent"> <a target="_blank" href="https://www.rsc.org/journals-books-databases/book-authors/propose-book-idea/" class="pubs-nav__link" tabindex="-1">For Authors and Editors</a> </li> <li class="pubs-nav__item pubs-nav__indent"> <a target="_blank" href="https://www.rsc.org/journals-books-databases/book-authors/" class="pubs-nav__link" tabindex="-1">About</a> </li> </ul> </div> <div class="pubs-nav__list autopad--h"> <h2 class="pubs-nav__heading">Databases</h2> <ul class="pubs-nav__ul"> <li class="pubs-nav__item pubs-nav__indent"> <a target="_blank" href="https://www.rsc.org/journals-books-databases/databases-literature-updates/" class="pubs-nav__link" tabindex="-1">Literature Updates</a> </li> <li class="pubs-nav__item pubs-nav__indent"> <a target="_blank" href="http://www.chemspider.com/" class="pubs-nav__link" tabindex="-1">ChemSpider</a> </li> <li class="pubs-nav__item pubs-nav__indent"> <a target="_blank" href="https://www.rsc.org/merck-index" class="pubs-nav__link" tabindex="-1">The Merck Index*</a> </li> <li class="pubs-nav__item pubs-nav__indent"> <a target="_blank" href="https://marinlit.rsc.org/" class="pubs-nav__link" tabindex="-1">MarinLit</a> </li> </ul> </div> <div class="pubs-nav__list autopad--h"> <h2 class="pubs-nav__heading">More</h2> <ul class="pubs-nav__ul"> <li class="pubs-nav__item pubs-nav__indent"> <a target="_blank" href="https://www.rsc.org/resources-tools/research-tools/#access" class="pubs-nav__link" tabindex="-1">For Members</a> </li> <li class="pubs-nav__item pubs-nav__indent"> <a target="_self" href="/en/librarian/home" class="pubs-nav__link" tabindex="-1">For Librarians</a> </li> <li class="pubs-nav__item pubs-nav__indent"> <a target="_blank" href="https://www.rsc.org/journals-books-databases/about-journals/journal-email-alerts-service/" class="pubs-nav__link" tabindex="-1">Subscribe</a> </li> <li class="pubs-nav__item pubs-nav__indent"> <a target="_self" href="/en/ealerts/rssfeed" class="pubs-nav__link" tabindex="-1">RSS Feeds</a> </li> <li class="pubs-nav__item pubs-nav__indent"> <a target="_blank" href="http://blogs.rsc.org/" class="pubs-nav__link" tabindex="-1">Blogs</a> </li> <li class="pubs-nav__item pubs-nav__indent"> <a target="_blank" href="https://www.chemistryworld.com/" class="pubs-nav__link" tabindex="-1">Chemistry World</a> </li> <li class="pubs-nav__item pubs-nav__indent"> <a target="_blank" href="https://edu.rsc.org/eic" class="pubs-nav__link" tabindex="-1">Education in Chemistry</a> </li> <li class="pubs-nav__item pubs-nav__indent"> <a target="_blank" href="https://www.rsc.org/journals-books-databases/open-access/" class="pubs-nav__link" tabindex="-1">Open Access</a> </li> <li class="pubs-nav__item pubs-nav__indent"> <a target="_blank" href="http://pubs.rsc.org/historical-collection" class="pubs-nav__link" tabindex="-1">Historical Collection</a> </li> </ul> </div> </div> </nav> </div> <script> var eCommerceGetOrderItemCountUrl = 'https://www.rsc.org/basket/shoppingcart/getorderitemcount'; var hideNotificationMessageUrl = '/en/home/HideNotificationMessage'; var brandingBarUrl = '/en/home/branding_New'; </script> <script src="https://www.rsc-cdn.org/pubs-core/2022.0.159/content/Scripts/dist/vendor.min.js"></script> <script src="https://www.rsc-cdn.org/pubs-core/2022.0.159/content/Scripts/dist/pubs-ui.min.js"></script> <script> var Model = { IsEnableRelatedContentTab: true, DownloadOptionAsync: '/en/content/checkaccess?msid=c3py01634j&type=article&pubyear=2014&sercode=py&publicationdate=2013-12-20&pubstatus=prt&doi=10.1039%2Fc3py01634j&ispdfexist=True&title=in%20situ%20forming%20biodegradable%20electroactive%20hydrogels&fulltext=xml&checkFullText=True&totalPages=11', ArticleTitleFull: '<em>in situ</em> forming biodegradable electroactive hydrogels - c3py01634j - sercode=py' }; var ALPTabs = { "Abstract": { hash: "divAbstract", link: "#btnAbstract", panel: "#pnlAbstract", content: "#divAbout", remoteUrl: "", }, "Citation": { hash: "divCitation", link: "#btnCitation", panel: "#pnlCitation", content: "#divCitation", remoteUrl: '/en/content/forwardlinks?doi=10.1039%2Fc3py01634j', }, "RelatedContent": { hash: "divRelatedContent", link: "#btnRelatedContent", panel: "#pnlRelatedContent", content: "#divRelatedContent", remoteUrl: '/en/content/relatedarticleschapters/c3py01634j?title=in%20situ%20forming%20biodegradable%20electroactive%20hydrogels&journalname=Polymer%20Chemistry&doctype=Paper&journalthemesCount=0&authorscount=4', subTabs: { "articles": { radio: "articles", links: "#RelatedArticle", content: "#RelatedArticles", hasContent: "hasRelatedArticles" }, "chapters": { radio: "chapters", links: "#RelatedBookChapter", content: "#RelatedBookChapters", hasContent: "hasRelatedBookChapters", }, "themes": { radio: "themes", links: "", content: "#themeIssueNWebcollection", hasContent: "hasRelatedThemes" } } } }; var CheckArticleHtmlButton = function CheckArticleHtmlButton() { var ahtmlBtn = $("a[href*='/content/articlehtml']"), ahtmlBtnText = $.trim(ahtmlBtn.text()), ahtmlBtnHref; if (ahtmlBtnText === "Article HTML") { ahtmlBtnHref = ahtmlBtn.attr("href"); $("#pnlArticleAccess").show(); BindRetryButton(ahtmlBtnHref); LoadArticleHtml(ahtmlBtnHref); } }; var LoadArticleHtml = function LoadArticleHtml(ahtmlUrl) { $.ajax({ url: ahtmlUrl, data: { t2: "y" }, success: function (data) { $("#pnlArticleAccess").remove(); $("#pnlArticleContentLoaded").html(data); LazyLoadImages(); StyleHeadings(); StyleTables(); }, error: function () { $("#thtmlLoadingMessage").hide(); $("#thtmlErrorMessage").show(); }, dataType: "html" }); }; var BindRetryButton = function BindRetryButton(ahtmlUrl) { $("#btnTryAgain").on("click", function (e) { e.preventDefault(); $("#thtmlLoadingMessage").show(); $("#thtmlErrorMessage").hide(); LoadArticleHtml(ahtmlUrl); }); }; var OpenPopupWindow = function OpenPopupWindow(url, width, height) { var left = (screen.width / 2) - (width / 2), top = (screen.height / 2) - (height / 2); window.open( url, "", "menubar=no,toolbar=no,resizable=yes,scrollbars=yes,width=" + width + ",height=" + height + ",top=" + top + ",left=" + left ); } var LazyLoadImages = function LazyLoadImages() { $("img[data-original]").lazyload({ effect: "fadeIn", threshold: 200 }); }; var StyleHeadings = function StyleHeadings() { $(".t-html h5.h--heading5").each(function (idx, el) { if ($(this).next().is("h6")) { $(this).css("display", "block").next().css("margin-top", "0"); } }); }; var StyleTables = function StyleTables() { $(".t-html table.table").each(function (idx, el) { var tw = $(this).width(); $(this).parent().css("min-width", tw * 0.8 + "px"); }); }; var ShowALPTab = function ShowALPTab(tabName) { if (ALPTabs.hasOwnProperty(tabName)) { var tab = ALPTabs[tabName], tabPanel = $(tab.panel), tabContent = $(tab.content); // Requires jQuery Address Plugin v1.5 (scripts/jquery.address-1.5.min.js) $.address.value(tab.hash); // If tab was not yet shown if (tabPanel.attr("data-loaded") === "false") { if (tab.remoteUrl) { pubsui.$handler.announcer.update(tabContent.text()); tabContent.load(tab.remoteUrl); } tabPanel.attr("data-loaded", "true"); } } }; $(document).ready(function () { var currentHash = window.location.hash, tabProps, subTabProps, $contentType = $("#contentType"); // Requires jQuery Address Plugin v1.5 (scripts/jquery.address-1.5.min.js) $.address.crawlable(true); $.address.strict(false); $(".btn-icon--loading").on("click", function (e) { e.preventDefault(); }); $("#DownloadOption").load(Model.DownloadOptionAsync, CheckArticleHtmlButton); // Bind all tabs $(".tab__btn").on("click", function () { ShowALPTab($(this).attr("id").substring(3)); }); // Bind social sharing buttons $(".btn--social").on("click", function (e) { e.preventDefault(); OpenPopupWindow($(this).attr("href"), 800, 600); }); // Override the initial tab selection if the URL hash matches an available tab for (tab in ALPTabs) { tabProps = ALPTabs[tab]; if (currentHash.indexOf(tabProps.hash) !== -1 && $(tabProps.link).length) { $(tabProps.link).trigger("click"); } } if (Model.IsEnableRelatedContentTab) { for (subTab in ALPTabs.RelatedContent.subTabs) { subTabProps = ALPTabs.RelatedContent.subTabs[subTab]; if (currentHash.indexOf(subTabProps.radio) !== -1) { $contentType.val(subTabProps.radio); } } } // Crossmark 'Check for updates' button if (!$("html").hasClass("ie8") && $(".crossmark-button").length) { $.ajax({ url: "https://crossmark-cdn.crossref.org/widget/v2.0/widget.js", dataType: "script", cache: true }).done(function() { $(".crossmark-button").addClass("visible"); }); } // Search articles by author form $("#Search").click(function () { var authorList = ''; var checkboxeschecked = ''; $('input[type=checkbox][data-givenname][data-familyname]').each(function () { if (this.checked) { checkboxeschecked = 'true'; authorList = $(this).data("givenname") + ":" + $(this).data("familyname") + "|" + authorList; } }); authorList = authorList.slice(0, authorList.length - 1); $("#selectedAuthors").attr("value", authorList); if (checkboxeschecked != 'true') { alert('Please select at least one author'); return false; } }); }); </script> <script src="https://cdn.pbgrd.com/core-rsc.js" async></script> </body> </html>

CINXE.COM

In situ forming biodegradable electroactive hydrogels - Polymer Chemistry (RSC Publishing)