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tumor</title> <meta name="description" content="Search results for: liver tumor"> <meta name="keywords" content="liver tumor"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" 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id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="liver tumor"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 1478</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: liver tumor</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1478</span> Liver Tumor Detection by Classification through FD Enhancement of CT Image</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=N.%20Ghatwary">N. Ghatwary</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Ahmed"> A. Ahmed</a>, <a href="https://publications.waset.org/abstracts/search?q=H.%20Jalab"> H. Jalab</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this paper, an approach for the liver tumor detection in computed tomography (CT) images is represented. The detection process is based on classifying the features of target liver cell to either tumor or non-tumor. Fractional differential (FD) is applied for enhancement of Liver CT images, with the aim of enhancing texture and edge features. Later on, a fusion method is applied to merge between the various enhanced images and produce a variety of feature improvement, which will increase the accuracy of classification. Each image is divided into NxN non-overlapping blocks, to extract the desired features. Support vector machines (SVM) classifier is trained later on a supplied dataset different from the tested one. Finally, the block cells are identified whether they are classified as tumor or not. Our approach is validated on a group of patients’ CT liver tumor datasets. The experiment results demonstrated the efficiency of detection in the proposed technique. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=fractional%20differential%20%28FD%29" title="fractional differential (FD)">fractional differential (FD)</a>, <a href="https://publications.waset.org/abstracts/search?q=computed%20tomography%20%28CT%29" title=" computed tomography (CT)"> computed tomography (CT)</a>, <a href="https://publications.waset.org/abstracts/search?q=fusion" title=" fusion"> fusion</a>, <a href="https://publications.waset.org/abstracts/search?q=aplha" title=" aplha"> aplha</a>, <a href="https://publications.waset.org/abstracts/search?q=texture%20features." title=" texture features."> texture features.</a> </p> <a href="https://publications.waset.org/abstracts/39719/liver-tumor-detection-by-classification-through-fd-enhancement-of-ct-image" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/39719.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">358</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1477</span> Undifferentiated Embryonal Sarcoma of Liver: A Rare Case Report</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Thieu-Thi%20Tra%20My">Thieu-Thi Tra My</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Undifferentiated embryonal sarcoma of the liver (UESL), a rare malignant mesenchymal tumor, is commonly seen in children. The symptoms and imaging were not specific, so it could be mimicked with other tumors or liver abscesses. The tumor often appears as a large heterogeneous echoic solid mass with small cystic areas while showing a cyst-like appearance on CT and MRI. The histopathological manifestation of the UESL consisted of stellate-shaped and spindle cells scattered on a myxoid background with high mitotic count. Cells with multiple or bizarre nuclear were also observed. Here, we aimed to describe a 9-year-old male diagnosed with UESL focused on imaging and histopathological characteristics. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=undifferentiated%20embryonal%20sarcoma%20of%20liver" title="undifferentiated embryonal sarcoma of liver">undifferentiated embryonal sarcoma of liver</a>, <a href="https://publications.waset.org/abstracts/search?q=UESL" title=" UESL"> UESL</a>, <a href="https://publications.waset.org/abstracts/search?q=liver%20sarcoma" title=" liver sarcoma"> liver sarcoma</a>, <a href="https://publications.waset.org/abstracts/search?q=liver%20tumor" title=" liver tumor"> liver tumor</a>, <a href="https://publications.waset.org/abstracts/search?q=children" title=" children"> children</a> </p> <a href="https://publications.waset.org/abstracts/170077/undifferentiated-embryonal-sarcoma-of-liver-a-rare-case-report" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/170077.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">74</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1476</span> Diagnosis and Analysis of Automated Liver and Tumor Segmentation on CT</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=R.%20R.%20Ramsheeja">R. R. Ramsheeja</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20Sreeraj"> R. Sreeraj</a> </p> <p class="card-text"><strong>Abstract:</strong></p> For view the internal structures of the human body such as liver, brain, kidney etc have a wide range of different modalities for medical images are provided nowadays. Computer Tomography is one of the most significant medical image modalities. In this paper use CT liver images for study the use of automatic computer aided techniques to calculate the volume of the liver tumor. Segmentation method is used for the detection of tumor from the CT scan is proposed. Gaussian filter is used for denoising the liver image and Adaptive Thresholding algorithm is used for segmentation. Multiple Region Of Interest(ROI) based method that may help to characteristic the feature different. It provides a significant impact on classification performance. Due to the characteristic of liver tumor lesion, inherent difficulties appear selective. For a better performance, a novel proposed system is introduced. Multiple ROI based feature selection and classification are performed. In order to obtain of relevant features for Support Vector Machine(SVM) classifier is important for better generalization performance. The proposed system helps to improve the better classification performance, reason in which we can see a significant reduction of features is used. The diagnosis of liver cancer from the computer tomography images is very difficult in nature. Early detection of liver tumor is very helpful to save the human life. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=computed%20tomography%20%28CT%29" title="computed tomography (CT)">computed tomography (CT)</a>, <a href="https://publications.waset.org/abstracts/search?q=multiple%20region%20of%20interest%28ROI%29" title=" multiple region of interest(ROI)"> multiple region of interest(ROI)</a>, <a href="https://publications.waset.org/abstracts/search?q=feature%20values" title=" feature values"> feature values</a>, <a href="https://publications.waset.org/abstracts/search?q=segmentation" title=" segmentation"> segmentation</a>, <a href="https://publications.waset.org/abstracts/search?q=SVM%20classification" title=" SVM classification"> SVM classification</a> </p> <a href="https://publications.waset.org/abstracts/18207/diagnosis-and-analysis-of-automated-liver-and-tumor-segmentation-on-ct" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/18207.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">509</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1475</span> Liver Transplantation after Downstaging with Electrochemotherapy of Large Hepatocellular Carcinoma and Portal Vein Tumor Thrombosis: A Case Report</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Luciano%20Tarantino">Luciano Tarantino</a>, <a href="https://publications.waset.org/abstracts/search?q=Emanuele%20Balzano"> Emanuele Balzano</a>, <a href="https://publications.waset.org/abstracts/search?q=Aurelio%20Nasto"> Aurelio Nasto</a> </p> <p class="card-text"><strong>Abstract:</strong></p> S.R. 53 years. January 2009: HCV-related cirrhosis, Child-Pugh A5 class, EGDS no aesophageal Varices. No important comorbidities. Treated with PEG-IFN+Ribavirin (march-november 2009) with subsequent sustained virologic response. HCVRNA absent overtime. October 2016 :CT detected small HCC nodule in the VIII segment (diam.=12 mm). Treated with US guided RF-ablation. November 2016 CT: complete necrosis. Unfortunately, the patient dropped out US and CT follow-up controls.September 2018: asthenia and weight loss. CT showed a large tumor infiltrating V-VII-VI segments and complete PVTT of right portal vein and its branches . Surgical Consultation excluded indication to Liver resection and OLT . 23 october 2018: ECT of a large peri-hilar area of the tumor including the PVTT. 1 and 3 months post-treatment CT showed complete necrosis and retraction of the thrombus and residual viable tumor in the peripheral portion of the right lobe . Therefor, the patient was reevaluated for OLT and considered eligible in waiting list . March 2019: CT showed no perihilar or portal vein recurrence and distant progression in the right lobe . March 2019 : Trans-arterial-Radio-therapy (TARE) of the right lobe. Post-treatment CT demonstrated no perihilar or portal vein recurrence and extensive necrosis of the residual tumor . December 2019: CT demonstrated several recurrences of HCC infiltrating the VI and VII segment . Howewer no recurrence was observed at hepatic hilum and in portal vessels . Therefore, on February 2020 the patient received OLT. At 44 months follow-up, no complication or recurrence or liver disfunction have been observed. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=hepatocellular%20carcinoma" title="hepatocellular carcinoma">hepatocellular carcinoma</a>, <a href="https://publications.waset.org/abstracts/search?q=portal%20vein%20tumor%20thrombosis" title=" portal vein tumor thrombosis"> portal vein tumor thrombosis</a>, <a href="https://publications.waset.org/abstracts/search?q=interventional%20ultrasound" title=" interventional ultrasound"> interventional ultrasound</a>, <a href="https://publications.waset.org/abstracts/search?q=liver%20tumor%20ablation" title=" liver tumor ablation"> liver tumor ablation</a>, <a href="https://publications.waset.org/abstracts/search?q=liver%20transplantation" title=" liver transplantation"> liver transplantation</a> </p> <a href="https://publications.waset.org/abstracts/172797/liver-transplantation-after-downstaging-with-electrochemotherapy-of-large-hepatocellular-carcinoma-and-portal-vein-tumor-thrombosis-a-case-report" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/172797.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">67</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1474</span> An Investigation of Etiology of Liver Cirrhosis and Its Complications with Other Co-morbid Diseases</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Tayba%20Akram">Tayba Akram</a> </p> <p class="card-text"><strong>Abstract:</strong></p> our main objective of this study is to work on the etiology of liver cirrhosis, to find basic reasons and causes of liver damage, and to find the pattern of liver cirrhosis in hepatic patients either suffering from hepatitis B/C or simple jaundice. We can evaluate medical treatment and the latest trends in patients suffering from liver cirrhosis. We can evaluate the side effects and adverse effects induced by drug therapy used to treat liver cirrhosis. The conclusion is based on the etiology of liver cirrhosis. The most common cause of liver cirrhosis is the viral Hepatitis C virus. Other common causes of liver cirrhosis that are estimated from our research are Hepatitis B virus, Diabetes Mellitus, Ascites, and very rarely found Hepatitis D virus. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=etiology" title="etiology">etiology</a>, <a href="https://publications.waset.org/abstracts/search?q=liver" title=" liver"> liver</a>, <a href="https://publications.waset.org/abstracts/search?q=cirrhosis" title=" cirrhosis"> cirrhosis</a>, <a href="https://publications.waset.org/abstracts/search?q=co-morbid%20diseases" title=" co-morbid diseases"> co-morbid diseases</a> </p> <a href="https://publications.waset.org/abstracts/193100/an-investigation-of-etiology-of-liver-cirrhosis-and-its-complications-with-other-co-morbid-diseases" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/193100.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">12</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1473</span> The Use of Brachytherapy in the Treatment of Liver Metastases: A Systematic Review</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mateusz%20Bilski">Mateusz Bilski</a>, <a href="https://publications.waset.org/abstracts/search?q=Jakub%20Klas"> Jakub Klas</a>, <a href="https://publications.waset.org/abstracts/search?q=Emilia%20Kowalczyk"> Emilia Kowalczyk</a>, <a href="https://publications.waset.org/abstracts/search?q=Sylwia%20Koziej"> Sylwia Koziej</a>, <a href="https://publications.waset.org/abstracts/search?q=Katarzyna%20Kulszo"> Katarzyna Kulszo</a>, <a href="https://publications.waset.org/abstracts/search?q=Ludmi%C5%82a%20Grzybowska-%20Szatkowska"> Ludmiła Grzybowska- Szatkowska</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Liver metastases are a common complication of primary solid tumors and sig-nificantly reduce patient survival. In the era of increasing diagnosis of oligometastatic disease and oligoprogression, methods of local treatment of metastases, i.e. MDT, are becoming more important. Implementation of such treatment can be considered for liver metastases, which are a common complication of primary solid tumors and significantly reduce patient survival. To date, the mainstay of treatment for oligometastatic disease has been surgical resection, but not all patients qualify for the procedure. As an alternative to surgical resection, radiotherapy techniques have become available, including stereotactic body radiation therapy (SBRT) or high-dose interstitial brachytherapy (iBT). iBT is an invasive method that emits very high doses of radiation from the inside of the tumor to the outside. This technique provides better tumor coverage than SBRT while having little impact on surrounding healthy tissue and elim-inates some concerns involving respiratory motion. Methods: We conducted a systematic re-view of the scientific literature on the use of brachytherapy in the treatment of liver metasta-ses from 2018 - 2023 using PubMed and ResearchGate browsers according to PRISMA rules. Results: From 111 articles, 18 publications containing information on 729 patients with liver metastases were selected. iBT has been shown to provide high rates of tumor control. Among 14 patients with 54 unresectable RCC liver metastases, after iBT LTC was 92.6% during a median follow-up of 10.2 months, PFS was 3.4 months. In analysis of 167 patients after treatment with a single fractional dose of 15-25 Gy with brachytherapy at 6- and 12-month follow-up, LRFS rates of 88,4-88.7% and 70.7 - 71,5%, PFS of 78.1 and 53.8%, and OS of 92.3 - 96.7% and 76,3% - 79.6%, respectively, were achieved. No serious complications were observed in all patients. Distant intrahepatic progression occurred later in patients with unre-sectable liver metastases after brachytherapy (PFS: 19.80 months) than in HCC patients (PFS: 13.50 months). A significant difference in LRFS between CRC patients (84.1% vs. 50.6%) and other histologies (92.4% vs. 92.4%) was noted, suggesting a higher treatment dose is necessary for CRC patients. The average target dose for metastatic colorectal cancer was 40 - 60 Gy (compared to 100 - 250 Gy for HCC). To better assess sensitivity to therapy and pre-dict side effects, it has been suggested that humoral mediators be evaluated. It was also shown that baseline levels of TNF-α, MCP-1 and VEGF, as well as NGF and CX3CL corre-lated with both tumor volume and radiation-induced liver damage, one of the most serious complications of iBT, indicating their potential role as biomarkers of therapy outcome. Con-clusions: The use of brachytherapy methods in the treatment of liver metastases of various cancers appears to be an interesting and relatively safe therapeutic method alternative to sur-gery. An important challenge remains the selection of an appropriate brachytherapy method and radiation dose for the corresponding initial tumor type from which the metastasis origi-nated. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=liver%20metastases" title="liver metastases">liver metastases</a>, <a href="https://publications.waset.org/abstracts/search?q=brachytherapy" title=" brachytherapy"> brachytherapy</a>, <a href="https://publications.waset.org/abstracts/search?q=CT-HDRBT" title=" CT-HDRBT"> CT-HDRBT</a>, <a href="https://publications.waset.org/abstracts/search?q=iBT" title=" iBT"> iBT</a> </p> <a href="https://publications.waset.org/abstracts/165821/the-use-of-brachytherapy-in-the-treatment-of-liver-metastases-a-systematic-review" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/165821.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">114</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1472</span> Protective Effect of Hesperidin against Cyclophosphamide Hepatotoxicity in Rats</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Amr%20A.%20Fouad">Amr A. Fouad</a>, <a href="https://publications.waset.org/abstracts/search?q=Waleed%20H.%20Albuali"> Waleed H. Albuali</a>, <a href="https://publications.waset.org/abstracts/search?q=Iyad%20Jresat"> Iyad Jresat</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The protective effect of hesperidin was investigated in rats exposed to liver injury induced by a single intraperitoneal injection of cyclophosphamide (CYP) at a dose of 150 mg kg-1. Hesperidin treatment (100 mg kg-1/day, orally) was applied for seven days, starting five days before CYP administration. Hesperidin significantly decreased the CYP-induced elevations of serum alanine aminotransferase, and hepatic malondialdehyde and myeloperoxidase activity, significantly prevented the depletion of hepatic glutathione peroxidase activity resulted from CYP administration. Also, hesperidin ameliorated the CYP-induced liver tissue injury observed by histopathological examination. In addition, hesperidin decreased the CYP-induced expression of inducible nitric oxide synthase, tumor necrosis factor-α, cyclooxygenase-2, Fas ligand, and caspase-9 in liver tissue. It was concluded that hesperidin may represent a potential candidate to protect against CYP-induced hepatotoxicity. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=hesperidin" title="hesperidin">hesperidin</a>, <a href="https://publications.waset.org/abstracts/search?q=cyclophosphamide" title=" cyclophosphamide"> cyclophosphamide</a>, <a href="https://publications.waset.org/abstracts/search?q=liver" title=" liver"> liver</a>, <a href="https://publications.waset.org/abstracts/search?q=rats" title=" rats"> rats</a> </p> <a href="https://publications.waset.org/abstracts/11037/protective-effect-of-hesperidin-against-cyclophosphamide-hepatotoxicity-in-rats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/11037.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">319</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1471</span> Diallyl Trisulfide Protects the Rat Liver from CCl4-Induced Injury and Fibrogenesis by Attenuating Oxidative Stress</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Xiao-Jing%20Zhu">Xiao-Jing Zhu</a>, <a href="https://publications.waset.org/abstracts/search?q=Liang%20Zhou"> Liang Zhou</a>, <a href="https://publications.waset.org/abstracts/search?q=Shi-Zhong%20Zheng"> Shi-Zhong Zheng</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Various studies have shown that diallyl trisulfide (DATS) can protect the liver injury, and DATS has a strong antioxidant property. The aim of this study is to evaluate the in vivo role of DATS in protecting the liver against injury and fibrogenesis and further explores the underlying mechanisms. Our results demonstrated that DATS protected the liver from CCl4-caused injury by suppressing the elevation of ALT and AST activities, and by improving the histological architecture of the liver. Treatment with DATS or colchicine improved the liver fibrosis by sirius red staining and immunofluorescence. In addition, immunohistochemistry, western blot, and RT-PCR analyses indicated that DATS inhibited HSC activation. Furthermore, DATS attenuated oxidative stress by increasing glutathione and reducing lipid peroxides and malondialdehyde. These findings suggest that the protective effect of DATS on CCl4-caused liver injury and liver fibrogenesis was, at least partially, attributed to its antioxidant activity. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=liver%20fibrogenesis" title="liver fibrogenesis">liver fibrogenesis</a>, <a href="https://publications.waset.org/abstracts/search?q=liver%20injury" title=" liver injury"> liver injury</a>, <a href="https://publications.waset.org/abstracts/search?q=oxidative%20stress" title=" oxidative stress"> oxidative stress</a>, <a href="https://publications.waset.org/abstracts/search?q=DATS" title=" DATS"> DATS</a> </p> <a href="https://publications.waset.org/abstracts/2858/diallyl-trisulfide-protects-the-rat-liver-from-ccl4-induced-injury-and-fibrogenesis-by-attenuating-oxidative-stress" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/2858.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">431</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1470</span> Chip Less Microfluidic Device for High Throughput Liver Spheroid Generation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sourita%20Ghosh">Sourita Ghosh</a>, <a href="https://publications.waset.org/abstracts/search?q=Falguni%20Pati"> Falguni Pati</a>, <a href="https://publications.waset.org/abstracts/search?q=Suhanya%20Duraiswamy"> Suhanya Duraiswamy</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Spheroid, a simple three-dimensional cellular aggregate, allows us to simulate the in-vivo complexity of cellular signaling and interactions in greater detail than traditional 2D cell culture. It can be used as an in-vitro model for drug toxicity testing, tumor modeling and many other such applications specifically for cancer. Our work is focused on the development of an affordable, user-friendly, robust, reproducible, high throughput microfluidic device for water in oil droplet production, which can, in turn, be used for spheroids manufacturing. Here, we have investigated the droplet breakup between two non-Newtonian fluids, viz. silicone oil and decellularized liver matrix, which acts as our extra cellular matrix (ECM) for spheroids formation. We performed some biochemical assays to characterize the liver ECM, as well as rheological studies on our two fluids and observed a critical dependence of capillary number (Ca) on droplet breakup and homogeneous drop formation <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=chip%20less" title="chip less">chip less</a>, <a href="https://publications.waset.org/abstracts/search?q=droplets" title=" droplets"> droplets</a>, <a href="https://publications.waset.org/abstracts/search?q=extracellular%20matrix" title=" extracellular matrix"> extracellular matrix</a>, <a href="https://publications.waset.org/abstracts/search?q=liver%20spheroid" title=" liver spheroid"> liver spheroid</a> </p> <a href="https://publications.waset.org/abstracts/165251/chip-less-microfluidic-device-for-high-throughput-liver-spheroid-generation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/165251.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">89</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1469</span> Nanotechnology-Based Treatment of Liver Cancer</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Lucian%20Mocan">Lucian Mocan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> We present method of Nanoparticle enhanced laser thermal ablation of HepG2 cells (Human hepatocellular liver carcinomacell line), using gold nanoparticles combuned with a specific growth factor and demonstrate its selective therapeutic efficacy usig ex vivo specimens. Ex vivo-perfused liver specimens were obtained from hepatocellular carcinoma patients similarly to the surgical technique of transplantation. Ab bound to GNPs was inoculated intra-arterially onto the resulting specimen and determined the specific delivery of the nano-bioconjugate into the malignant tissue by means of the capillary bed. The extent of necrosis was considerable following laser therapy and at the same time surrounding parenchyma was not seriously affected. The selective photothermal ablation of the malignant liver tissue was obtained after the selective accumulation of Ab bound to GNPs into tumor cells following ex-vivo intravascular perfusion. These unique results may represent a major step in liver cancer treatment using nanolocalized thermal ablation by laser heating. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=HepG2%20cells" title="HepG2 cells">HepG2 cells</a>, <a href="https://publications.waset.org/abstracts/search?q=gold%20nanoparticles" title=" gold nanoparticles"> gold nanoparticles</a>, <a href="https://publications.waset.org/abstracts/search?q=nanoparticle%20functionalization" title=" nanoparticle functionalization"> nanoparticle functionalization</a>, <a href="https://publications.waset.org/abstracts/search?q=laser%20irradiation" title=" laser irradiation"> laser irradiation</a> </p> <a href="https://publications.waset.org/abstracts/66957/nanotechnology-based-treatment-of-liver-cancer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/66957.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">368</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1468</span> Electrochemotherapy of Portal Vein Tumor Thrombus as Dowstaging to Liver Transplantation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Luciano%20Tarantino">Luciano Tarantino</a>, <a href="https://publications.waset.org/abstracts/search?q=Emanuele%20Balzano"> Emanuele Balzano</a>, <a href="https://publications.waset.org/abstracts/search?q=Paolo%20Tarantino"> Paolo Tarantino</a>, <a href="https://publications.waset.org/abstracts/search?q=Riccardo%20Aurelio%20Nasto"> Riccardo Aurelio Nasto</a>, <a href="https://publications.waset.org/abstracts/search?q=Aurelio%20Nasto"> Aurelio Nasto</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Liver transplantation (OLT) is contraindicate in Portal Vein tumor Thrombosis (PVTT) from Hepatocellular Carcinoma at hepatic hilum(pH-HCC) Surgery,Thermal ablation and chemotherapy show poorer outcomes Electrochemotherapy (ECT) has been successfully used in patients with pH-HCC with PVTT. We report the results of ECT as downstaging aimed to definitive cure by OLT. F.P. 53 years HBV related Cirrhosis Child-Pugh B7 class; EGDS F2 aesophageal Varices. Diabetes. April 2016 : Enhanced Computed Tomography (CT) detected HCC(n.3 nodules in VII-VIII-VI;diameter range=25 cm) and PVTT of right portal vein. The patient was considered ineligible for OLT. May 2016: first ablation session with percutaneous Radiofrequency-ablation(RFA) of 3 HCC-nodules . August 2016: second ablation session with ECT of PVTT. CT october 2016: disappearance of PVTT and patent right portal vein. No intraparenchymal recurrence. CT march 2017: No recurrence in portal vein and in the left lobe. local recurrence in the VII-VIII segments. May 2017 : transarterial chemoembolization (TACE) of right lobe recurrences. CT October 2017: patent right portal vein. No recurrence. The patient was reconsidered for OLT. He underwent OLT in April 2018. At 36-months follow-up , no intrahepatic recurrence of HCC occurred. March 2021: enhanced CT and PET/CT detected a single small nodule (1.5 cm) uptaking tracer in the left upper pulmonary lobe, no hepatic recurrence . CT-guided FNB showed metastasis from HCC . June 2021: left lung upper lobectomy . At the current time the patient is alive and recurrence-free at 64 months follow-up. ECT Could be aneffective technique as pre-OLT dowstaging in HCC with PVTT. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=liver%20tumor%20ablation" title="liver tumor ablation">liver tumor ablation</a>, <a href="https://publications.waset.org/abstracts/search?q=interventional%20ultrasound" title=" interventional ultrasound"> interventional ultrasound</a>, <a href="https://publications.waset.org/abstracts/search?q=electrochemotherapy" title=" electrochemotherapy"> electrochemotherapy</a>, <a href="https://publications.waset.org/abstracts/search?q=liver%20transplantation" title=" liver transplantation"> liver transplantation</a> </p> <a href="https://publications.waset.org/abstracts/172793/electrochemotherapy-of-portal-vein-tumor-thrombus-as-dowstaging-to-liver-transplantation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/172793.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">118</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1467</span> Diagnostic Performance of Tumor Associated Trypsin Inhibitor in Early Detection of Hepatocellular Carcinoma in Patients with Hepatitis C Virus </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Aml%20M.%20El-Sharkawy">Aml M. El-Sharkawy</a>, <a href="https://publications.waset.org/abstracts/search?q=Hossam%20M.%20Darwesh"> Hossam M. Darwesh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Abstract— Background/Aim: Hepatocellular carcinoma (HCC) is often diagnosed at advanced stage where effective therapies are lacking. Identification of new scoring system is needed to discriminate HCC patients from those with chronic liver disease. Based on the link between tumor associated trypsin inhibitor (TATI) and HCC progression, we aimed to develop a novel score based on combination of TATI and routine laboratory tests for early prediction of HCC. Methods: TATI was assayed for HCC group (123), liver cirrhosis group (210) and control group (50) by Enzyme Linked Immunosorbent Assay (ELISA). Data from all groups were retrospectively analyzed including α feto protein (AFP), international normalized ratio (INR), albumin and platelet count, transaminases, and age. Areas under ROC curve were used to develop the score. Results: A novel index named hepatocellular carcinoma-vascular endothelial growth factor score (HCC-TATI score) = 3.1 (numerical constant) + 0.09 ×AFP (U L-1) + 0.067 × TATI (ng ml-1) + 0.16 × INR – 1.17 × Albumin (g l-1) – 0.032 × Platelet count × 109 l-1 was developed. HCC-TATI score produce area under ROC curve of 0.98 for discriminating HCC patients from liver cirrhosis with sensitivity of 91% and specificity of 82% at cut-off 6.5 (ie less than 6.5 considered cirrhosis and greater than 4.4 considered HCC). Conclusion: Hepatocellular carcinoma-TATI score could replace AFP in HCC screening and follow up of cirrhotic patients. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hepatocellular%20carcinoma" title="Hepatocellular carcinoma">Hepatocellular carcinoma</a>, <a href="https://publications.waset.org/abstracts/search?q=cirrhosis" title=" cirrhosis"> cirrhosis</a>, <a href="https://publications.waset.org/abstracts/search?q=HCV" title=" HCV"> HCV</a>, <a href="https://publications.waset.org/abstracts/search?q=diagnosis" title=" diagnosis"> diagnosis</a>, <a href="https://publications.waset.org/abstracts/search?q=TATI" title=" TATI "> TATI </a> </p> <a href="https://publications.waset.org/abstracts/20583/diagnostic-performance-of-tumor-associated-trypsin-inhibitor-in-early-detection-of-hepatocellular-carcinoma-in-patients-with-hepatitis-c-virus" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/20583.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">337</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1466</span> Grape Seed Extract in Prevention and Treatment of Liver Toxic Cirrhosis in Rats </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=S.%20Buloyan">S. Buloyan</a>, <a href="https://publications.waset.org/abstracts/search?q=V.%20Mamikonyan"> V. Mamikonyan</a>, <a href="https://publications.waset.org/abstracts/search?q=H.%20Hakobyan"> H. Hakobyan</a>, <a href="https://publications.waset.org/abstracts/search?q=H.%20Harutyunyan"> H. Harutyunyan</a>, <a href="https://publications.waset.org/abstracts/search?q=H.%20Gasparyan"> H. Gasparyan </a> </p> <p class="card-text"><strong>Abstract:</strong></p> The liver is the strongest regenerating organ of the organism, and even with 2/3 surgically removed, it can regenerate completely. Hence, liver cirrhosis may only develop when the regenerating system is off. We present the results of a comparative study of structural and functional characteristics of rat liver tissue under the conditions of toxic liver cirrhosis development, induced by carbon tetrachloride, and its prevention/treatment by natural compounds with antioxidant and immune stimulating action. Studies were made on Wister rats, weighing 120~140 g. Grape seeds extracts, separately and in combination with well known anticirrhotic drug ursodeoxycholic acid (ursodiol) have demonstrated effectiveness in prevention of liver cirrhosis development and its treatment. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=carbon%20tetrachloride" title="carbon tetrachloride">carbon tetrachloride</a>, <a href="https://publications.waset.org/abstracts/search?q=GSE" title=" GSE"> GSE</a>, <a href="https://publications.waset.org/abstracts/search?q=liver%20cirrhosis" title=" liver cirrhosis"> liver cirrhosis</a>, <a href="https://publications.waset.org/abstracts/search?q=prevention" title=" prevention"> prevention</a>, <a href="https://publications.waset.org/abstracts/search?q=treatment" title=" treatment "> treatment </a> </p> <a href="https://publications.waset.org/abstracts/15653/grape-seed-extract-in-prevention-and-treatment-of-liver-toxic-cirrhosis-in-rats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/15653.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">486</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1465</span> PCR Based DNA Analysis in Detecting P53 Mutation in Human Breast Cancer (MDA-468)</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Debbarma%20Asis">Debbarma Asis</a>, <a href="https://publications.waset.org/abstracts/search?q=Guha%20Chandan"> Guha Chandan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Tumor Protein-53 (P53) is one of the tumor suppressor proteins. P53 regulates the cell cycle that conserves stability by preventing genome mutation. It is named so as it runs as 53-kilodalton (kDa) protein on Polyacrylamide gel electrophoresis although the actual mass is 43.7 kDa. Experimental evidence has indicated that P53 cancer mutants loses tumor suppression activity and subsequently gain oncogenic activities to promote tumourigenesis. Tumor-specific DNA has recently been detected in the plasma of breast cancer patients. Detection of tumor-specific genetic materials in cancer patients may provide a unique and valuable tumor marker for diagnosis and prognosis. Commercially available MDA-468 breast cancer cell line was used for the proposed study. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=tumor%20protein%20%28P53%29" title="tumor protein (P53)">tumor protein (P53)</a>, <a href="https://publications.waset.org/abstracts/search?q=cancer%20mutants" title=" cancer mutants"> cancer mutants</a>, <a href="https://publications.waset.org/abstracts/search?q=MDA-468" title=" MDA-468"> MDA-468</a>, <a href="https://publications.waset.org/abstracts/search?q=tumor%20suppressor%20gene" title=" tumor suppressor gene"> tumor suppressor gene</a> </p> <a href="https://publications.waset.org/abstracts/43690/pcr-based-dna-analysis-in-detecting-p53-mutation-in-human-breast-cancer-mda-468" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/43690.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">478</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1464</span> Ultra Wideband Breast Cancer Detection by Using SAR for Indication the Tumor Location</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Wittawat%20Wasusathien">Wittawat Wasusathien</a>, <a href="https://publications.waset.org/abstracts/search?q=Samran%20Santalunai"> Samran Santalunai</a>, <a href="https://publications.waset.org/abstracts/search?q=Thanaset%20Thosdeekoraphat"> Thanaset Thosdeekoraphat</a>, <a href="https://publications.waset.org/abstracts/search?q=Chanchai%20Thongsopa"> Chanchai Thongsopa</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This paper presents breast cancer detection by observing the specific absorption rate (SAR) intensity for identification tumor location, the tumor is identified in coordinates (x,y,z) system. We examined the frequency between 4-8 GHz to look for the most appropriate frequency. Results are simulated in frequency 4-8 GHz, the model overview include normal breast with 50 mm radian, 5 mm diameter of tumor, and ultra wideband (UWB) bowtie antenna. The models are created and simulated in CST Microwave Studio. For this simulation, we changed antenna to 5 location around the breast, the tumor can be detected when an antenna is close to the tumor location, which the coordinate of maximum SAR is approximated the tumor location. For reliable, we experiment by random tumor location to 3 position in the same size of tumor and simulation the result again by varying the antenna position in 5 position again, and it also detectable the tumor position from the antenna that nearby tumor position by maximum value of SAR, which it can be detected the tumor with precision in all frequency between 4-8 GHz. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=specific%20absorption%20rate%20%28SAR%29" title="specific absorption rate (SAR)">specific absorption rate (SAR)</a>, <a href="https://publications.waset.org/abstracts/search?q=ultra%20wideband%20%28UWB%29" title=" ultra wideband (UWB)"> ultra wideband (UWB)</a>, <a href="https://publications.waset.org/abstracts/search?q=coordinates" title=" coordinates"> coordinates</a>, <a href="https://publications.waset.org/abstracts/search?q=cancer%20detection" title=" cancer detection"> cancer detection</a> </p> <a href="https://publications.waset.org/abstracts/10465/ultra-wideband-breast-cancer-detection-by-using-sar-for-indication-the-tumor-location" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/10465.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">403</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1463</span> Physiochemical and Histological Study on the Effect of the Hibernation on the Liver of Uromastyx acanthinura (Bell, 1825)</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Youssef.%20K.%20A.%20Abdalhafid">Youssef. K. A. Abdalhafid</a>, <a href="https://publications.waset.org/abstracts/search?q=Ezaldin%20A.%20M.%20Mohammed"> Ezaldin A. M. Mohammed</a>, <a href="https://publications.waset.org/abstracts/search?q=Masoud%20M.%20M.%20Zatout"> Masoud M. M. Zatout </a> </p> <p class="card-text"><strong>Abstract:</strong></p> This study described the changes in the liver of Uromastyx acanthinura (Bell, 1825) males and females during hibernation and activity seasons. The results revealed that, hibernation causes increase fatty liver and pigment cells with abundant damage, comparing with nearly normal structure and less fatty liver after the hibernation with almost normal pattern. Genomic DNA showed apparent separation during hibernation. Also, caspase 3 and caspase 7 activity reached a high level in the liver tissue during hibernation comparing with activity season. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=histological%20liver" title="histological liver">histological liver</a>, <a href="https://publications.waset.org/abstracts/search?q=DNA%20fragmentation" title=" DNA fragmentation"> DNA fragmentation</a>, <a href="https://publications.waset.org/abstracts/search?q=hibernation" title=" hibernation"> hibernation</a>, <a href="https://publications.waset.org/abstracts/search?q=caspase%203%20and%20caspase%207" title=" caspase 3 and caspase 7 "> caspase 3 and caspase 7 </a> </p> <a href="https://publications.waset.org/abstracts/14146/physiochemical-and-histological-study-on-the-effect-of-the-hibernation-on-the-liver-of-uromastyx-acanthinura-bell-1825" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/14146.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">317</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1462</span> Regression of Fibrosis by Apigenin in Thioacetamide-Induced Liver Fibrosis Rat Model through Suppression of HIF-1/FAK Pathway</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hany%20M.%20Fayed">Hany M. Fayed</a>, <a href="https://publications.waset.org/abstracts/search?q=Rehab%20F.%20Abdel-Rahman"> Rehab F. Abdel-Rahman</a>, <a href="https://publications.waset.org/abstracts/search?q=Alyaa%20F.%20Hessin"> Alyaa F. Hessin</a>, <a href="https://publications.waset.org/abstracts/search?q=Hanan%20A.%20Ogaly"> Hanan A. Ogaly</a>, <a href="https://publications.waset.org/abstracts/search?q=Gihan%20F.%20Asaad"> Gihan F. Asaad</a>, <a href="https://publications.waset.org/abstracts/search?q=Abeer%20A.%20A.%20Salama"> Abeer A. A. Salama</a>, <a href="https://publications.waset.org/abstracts/search?q=Sahar%20Abdelrahman"> Sahar Abdelrahman</a>, <a href="https://publications.waset.org/abstracts/search?q=Mahmoud%20S.%20Arbid"> Mahmoud S. Arbid</a>, <a href="https://publications.waset.org/abstracts/search?q=Marwan%20Abd%20Elbaset%20Mohamed"> Marwan Abd Elbaset Mohamed</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Liver fibrosis is a serious global health problem that occurs as a result of a variety of chronic liver disorders. Apigenin, a flavonoid found in many plants, has several pharmacological properties. The aim of this study was to evaluate the antifibrotic efficacy of apigenin (APG) against experimentally induced hepatic fibrosis in rats via using thioacetamide (TAA) and to explore the possible underlying mechanisms. TAA (100 mg/kg, i.p.) was given three times each week for two weeks to induce liver fibrosis. After TAA injections, APG was given orally (5 and 10 mg/kg) daily for two weeks. Biochemical, molecular, histological and immunohistochemical analyses were performed on blood and liver tissue samples. The functioning of the liver, oxidative stress, inflammation, and liver fibrosis indicators were all evaluated. The findings showed that TAA markedly increased the activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), as well as the levels of malondialdehyde (MDA), focal adhesion kinase (FAK), hypoxia-inducible factor-1 (HIF-1), nuclear factor-κB (NF-κB), transforming growth factor-beta (TGF-β), tumor necrosis factor-alpha (TNF-α) and interleukin-1β (IL-1β) with a reduction in albumin, total protein, A/G ratio, GSH content and interleukin-10 (IL-10). Moreover, TAA elevated the content of collagen I, α -smooth muscle actin (α-SMA), and hydroxyproline in the liver. The treatment with APG in a dose-dependent manner has obviously prevented these alterations and amended the harmful effects induced by TAA. The histopathological and immunohistochemical observations supported this biochemical evidence. The higher dose of APG produced the most significant antifibrotic effect. As a result of these data, APG appears to be a promising antifibrotic drug and could be used as a new herbal medication or dietary supplement in the future for the treatment of liver fibrosis. This effect might be related to the inhibition of the HIF-1/FAK signaling pathway. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=apigenin" title="apigenin">apigenin</a>, <a href="https://publications.waset.org/abstracts/search?q=FAK" title=" FAK"> FAK</a>, <a href="https://publications.waset.org/abstracts/search?q=HIF-1" title=" HIF-1"> HIF-1</a>, <a href="https://publications.waset.org/abstracts/search?q=liver%20fibrosis" title=" liver fibrosis"> liver fibrosis</a>, <a href="https://publications.waset.org/abstracts/search?q=rat" title=" rat"> rat</a>, <a href="https://publications.waset.org/abstracts/search?q=thioacetamide" title=" thioacetamide"> thioacetamide</a> </p> <a href="https://publications.waset.org/abstracts/148178/regression-of-fibrosis-by-apigenin-in-thioacetamide-induced-liver-fibrosis-rat-model-through-suppression-of-hif-1fak-pathway" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/148178.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">134</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1461</span> Liver Transplant for Hepatocellular Carcinoma: Single Medical Center Experience in Taiwan</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Yu-Chih%20Wang">Yu-Chih Wang</a>, <a href="https://publications.waset.org/abstracts/search?q=Chia-Yu%20Lai"> Chia-Yu Lai</a>, <a href="https://publications.waset.org/abstracts/search?q=Hsiao-Tien%20Liu"> Hsiao-Tien Liu</a>, <a href="https://publications.waset.org/abstracts/search?q=Yi-Ju%20Chen"> Yi-Ju Chen</a>, <a href="https://publications.waset.org/abstracts/search?q=Shao-Bin%20Cheng"> Shao-Bin Cheng</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Liver transplant has been one of the curative treatment options for hepatocellular carcinomaunder certain oncological conditions. Two of the most validated criteria are from Milan in1996 and USCF in 2001, suggesting number and size limits of tumor without vascularinvasion or distant metastasis. We performed a retrospective cohort study of hepatocellular carcinoma patients undergoing livertransplant between August 2003 and December 2020 in our institute. Clinical andpathological characteristic, survival outcome, and recurrent pattern were analysed.UCSF criteria was applied for living donor transplantation, and Milan criteria was applied for deceased donor transplantation. Of 180 total patients, 52 cases(28.8%) with diagnosis of hepatocellular carcinoma, including26 living donor(LD) and 26 deceased donor(DD) liver transplant. Complete pathologicalremission was significantly more in the DD group(p=0.009). Pathological reports showed that30.8% of DD group exceeded Milan criteria, and 19.2% of LD group exceeded UCSFcriteria.After a median follow-up of 52.2 months, the 1-year, 3-year and 5-year overall survival was 87.6%, 74.1%, and 71.8%, respectively.Meanwhile, progression-free survival was 93.1%, 85.7%, and 81.6% for 1, 3, and 5-year, respectively, similar to that in Mazzaferro et al, 1996. We concluded that Liver transplant could be applied cautiously in expanded criteria for patent withhepatocellular carcinoma. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=liver%20transplant" title="liver transplant">liver transplant</a>, <a href="https://publications.waset.org/abstracts/search?q=milan%20criteria" title=" milan criteria"> milan criteria</a>, <a href="https://publications.waset.org/abstracts/search?q=UCSF%20criteria" title=" UCSF criteria"> UCSF criteria</a>, <a href="https://publications.waset.org/abstracts/search?q=living%20donor%20transplantation" title=" living donor transplantation"> living donor transplantation</a>, <a href="https://publications.waset.org/abstracts/search?q=deceased%20donor%20transplantation" title=" deceased donor transplantation"> deceased donor transplantation</a> </p> <a href="https://publications.waset.org/abstracts/149275/liver-transplant-for-hepatocellular-carcinoma-single-medical-center-experience-in-taiwan" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/149275.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">154</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1460</span> A Fuzzy Approach to Liver Tumor Segmentation with Zernike Moments </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Abder-Rahman%20Ali">Abder-Rahman Ali</a>, <a href="https://publications.waset.org/abstracts/search?q=Antoine%20Vacavant"> Antoine Vacavant</a>, <a href="https://publications.waset.org/abstracts/search?q=Manuel%20Grand-Brochier"> Manuel Grand-Brochier</a>, <a href="https://publications.waset.org/abstracts/search?q=Ad%C3%A9la%C3%AFde%20Albouy-Kissi"> Adélaïde Albouy-Kissi</a>, <a href="https://publications.waset.org/abstracts/search?q=Jean-Yves%20Boire"> Jean-Yves Boire</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this paper, we present a new segmentation approach for liver lesions in regions of interest within MRI (Magnetic Resonance Imaging). This approach, based on a two-cluster Fuzzy C-Means methodology, considers the parameter variable compactness to handle uncertainty. Fine boundaries are detected by a local recursive merging of ambiguous pixels with a sequential forward floating selection with Zernike moments. The method has been tested on both synthetic and real images. When applied on synthetic images, the proposed approach provides good performance, segmentations obtained are accurate, their shape is consistent with the ground truth, and the extracted information is reliable. The results obtained on MR images confirm such observations. Our approach allows, even for difficult cases of MR images, to extract a segmentation with good performance in terms of accuracy and shape, which implies that the geometry of the tumor is preserved for further clinical activities (such as automatic extraction of pharmaco-kinetics properties, lesion characterization, etc). <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=defuzzification" title="defuzzification">defuzzification</a>, <a href="https://publications.waset.org/abstracts/search?q=floating%20search" title=" floating search"> floating search</a>, <a href="https://publications.waset.org/abstracts/search?q=fuzzy%20clustering" title=" fuzzy clustering"> fuzzy clustering</a>, <a href="https://publications.waset.org/abstracts/search?q=Zernike%20moments" title=" Zernike moments "> Zernike moments </a> </p> <a href="https://publications.waset.org/abstracts/32509/a-fuzzy-approach-to-liver-tumor-segmentation-with-zernike-moments" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/32509.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">452</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1459</span> Histomorphological Comparisons of Liver of Broiler Chickens and Wild Boar in Algeria</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Khenenou%20Tarek">Khenenou Tarek</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Aim: The objective of present study was to compare the normal macro and microscopic appearance of the liver in two very different species, one is an omnivorous mammal; the wild boar and the other belongs to the family of poultry; broiler chicken from the region of Bouhmama (Khenchela). Materials and methods: Eight broilers (58 days of age) and eight wild boars were included in the experiment to obtain information about the morpho-histological appearances of liver in two species. Results: There is a big difference in the liver appearance between the two species, in the wild boar it is of firm consistency with a tiger aspect and divided into four lobes, whereas in the broiler, the liver is brown and sometimes pale during the first 10-14 days, so it was divided into two lobes. Concerning the liver parenchyma, we used the Russian LOMBO MBS-10 stereo microscope, our results showed that the liver parenchyma was well developed in wild boar than in broiler chickens whereas, in broiler chickens; an excessive development of the sinus; the latter were less developed in the wild boar. Conclusion: The macroscopic observation showed a marked difference in liver between the two species. The microscopic examination of liver showed that the parenchyma is less pronounced in broilers whereas the sinuses were highly developed in the wild boar. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=broiler%20chicken" title="broiler chicken">broiler chicken</a>, <a href="https://publications.waset.org/abstracts/search?q=liver" title=" liver"> liver</a>, <a href="https://publications.waset.org/abstracts/search?q=macro%20and%20microscopic%20appearances" title=" macro and microscopic appearances"> macro and microscopic appearances</a>, <a href="https://publications.waset.org/abstracts/search?q=wild%20boar" title=" wild boar"> wild boar</a>, <a href="https://publications.waset.org/abstracts/search?q=Algeria" title=" Algeria"> Algeria</a> </p> <a href="https://publications.waset.org/abstracts/190129/histomorphological-comparisons-of-liver-of-broiler-chickens-and-wild-boar-in-algeria" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/190129.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">21</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1458</span> Evaluating the Diagnostic Accuracy of the ctDNA Methylation for Liver Cancer</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Maomao%20Cao">Maomao Cao</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Objective: To test the performance of ctDNA methylation for the detection of liver cancer. Methods: A total of 1233 individuals have been recruited in 2017. 15 male and 15 female samples (including 10 cases of liver cancer) were randomly selected in the present study. CfDNA was extracted by MagPure Circulating DNA Maxi Kit. The concentration of cfDNA was obtained by Qubit™ dsDNA HS Assay Kit. A pre-constructed predictive model was used to analyze methylation data and to give a predictive score for each cfDNA sample. Individuals with a predictive score greater than or equal to 80 were classified as having liver cancer. CT tests were considered the gold standard. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for the diagnosis of liver cancer were calculated. Results: 9 patients were diagnosed with liver cancer according to the prediction model (with high sensitivity and threshold of 80 points), with scores of 99.2, 91.9, 96.6, 92.4, 91.3, 92.5, 96.8, 91.1, and 92.2, respectively. The sensitivity, specificity, positive predictive value, and negative predictive value of ctDNA methylation for the diagnosis of liver cancer were 0.70, 0.90, 0.78, and 0.86, respectively. Conclusions: ctDNA methylation could be an acceptable diagnostic modality for the detection of liver cancer. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=liver%20cancer" title="liver cancer">liver cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=ctDNA%20methylation" title=" ctDNA methylation"> ctDNA methylation</a>, <a href="https://publications.waset.org/abstracts/search?q=detection" title=" detection"> detection</a>, <a href="https://publications.waset.org/abstracts/search?q=diagnostic%20performance" title=" diagnostic performance"> diagnostic performance</a> </p> <a href="https://publications.waset.org/abstracts/146512/evaluating-the-diagnostic-accuracy-of-the-ctdna-methylation-for-liver-cancer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/146512.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">150</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1457</span> Detecting HCC Tumor in Three Phasic CT Liver Images with Optimization of Neural Network</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mahdieh%20Khalilinezhad">Mahdieh Khalilinezhad</a>, <a href="https://publications.waset.org/abstracts/search?q=Silvana%20Dellepiane"> Silvana Dellepiane</a>, <a href="https://publications.waset.org/abstracts/search?q=Gianni%20Vernazza"> Gianni Vernazza</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The aim of the present work is to build a model based on tissue characterization that is able to discriminate pathological and non-pathological regions from three-phasic CT images. Based on feature selection in different phases, in this research, we design a neural network system that has optimal neuron number in a hidden layer. Our approach consists of three steps: feature selection, feature reduction, and classification. For each ROI, 6 distinct set of texture features are extracted such as first order histogram parameters, absolute gradient, run-length matrix, co-occurrence matrix, autoregressive model, and wavelet, for a total of 270 texture features. We show that with the injection of liquid and the analysis of more phases the high relevant features in each region changed. Our results show that for detecting HCC tumor phase3 is the best one in most of the features that we apply to the classification algorithm. The percentage of detection between these two classes according to our method, relates to first order histogram parameters with the accuracy of 85% in phase 1, 95% phase 2, and 95% in phase 3. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=multi-phasic%20liver%20images" title="multi-phasic liver images">multi-phasic liver images</a>, <a href="https://publications.waset.org/abstracts/search?q=texture%20analysis" title=" texture analysis"> texture analysis</a>, <a href="https://publications.waset.org/abstracts/search?q=neural%20network" title=" neural network"> neural network</a>, <a href="https://publications.waset.org/abstracts/search?q=hidden%20layer" title=" hidden layer"> hidden layer</a> </p> <a href="https://publications.waset.org/abstracts/26386/detecting-hcc-tumor-in-three-phasic-ct-liver-images-with-optimization-of-neural-network" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/26386.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">262</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1456</span> Liver and Liver Lesion Segmentation From Abdominal CT Scans</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Belgherbi%20Aicha">Belgherbi Aicha</a>, <a href="https://publications.waset.org/abstracts/search?q=Hadjidj%20Ismahen"> Hadjidj Ismahen</a>, <a href="https://publications.waset.org/abstracts/search?q=Bessaid%20Abdelhafid"> Bessaid Abdelhafid</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The interpretation of medical images benefits from anatomical and physiological priors to optimize computer- aided diagnosis applications. Segmentation of liver and liver lesion is regarded as a major primary step in computer aided diagnosis of liver diseases. Precise liver segmentation in abdominal CT images is one of the most important steps for the computer-aided diagnosis of liver pathology. In this papers, a semi- automated method for medical image data is presented for the liver and liver lesion segmentation data using mathematical morphology. Our algorithm is currency in two parts. In the first, we seek to determine the region of interest by applying the morphological filters to extract the liver. The second step consists to detect the liver lesion. In this task; we proposed a new method developed for the semi-automatic segmentation of the liver and hepatic lesions. Our proposed method is based on the anatomical information and mathematical morphology tools used in the image processing field. At first, we try to improve the quality of the original image and image gradient by applying the spatial filter followed by the morphological filters. The second step consists to calculate the internal and external markers of the liver and hepatic lesions. Thereafter we proceed to the liver and hepatic lesions segmentation by the watershed transform controlled by markers. The validation of the developed algorithm is done using several images. Obtained results show the good performances of our proposed algorithm <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=anisotropic%20diffusion%20filter" title="anisotropic diffusion filter">anisotropic diffusion filter</a>, <a href="https://publications.waset.org/abstracts/search?q=CT%20images" title=" CT images"> CT images</a>, <a href="https://publications.waset.org/abstracts/search?q=hepatic%20lesion%20segmentation" title=" hepatic lesion segmentation"> hepatic lesion segmentation</a>, <a href="https://publications.waset.org/abstracts/search?q=Liver%20segmentation" title=" Liver segmentation"> Liver segmentation</a>, <a href="https://publications.waset.org/abstracts/search?q=morphological%20filter" title=" morphological filter"> morphological filter</a>, <a href="https://publications.waset.org/abstracts/search?q=the%20watershed%20algorithm" title=" the watershed algorithm"> the watershed algorithm</a> </p> <a href="https://publications.waset.org/abstracts/20381/liver-and-liver-lesion-segmentation-from-abdominal-ct-scans" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/20381.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">451</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1455</span> Comparative Stem Cells Therapy for Regeneration of Liver Fibrosis </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=H.%20M.%20Imam">H. M. Imam</a>, <a href="https://publications.waset.org/abstracts/search?q=H.%20M.%20Rezk"> H. M. Rezk</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20F.%20Tohamy"> A. F. Tohamy </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Human umbilical cord blood (HUCB) is considered as a unique source for stem cells. HUCB contain different types of progenitor cells which could differentiate into hepatocytes. Aims: To investigate the potential of rat's liver damage repair using human umbilical cord mesenchymal stem cells (hUCMSCs). We investigated the feasibility for hUCMSCs in recovery from liver damage. Moreover, investigating fibrotic liver repair and using the CCl4-induced model for liver damage in the rat. Methods: Rats were injected with 0.5 ml/kg CCl4 to induce liver damage and progressive liver fibrosis. hUCMSCs were injected into the rats through the tail vein; Stem cells were transplanted at a dose of 1×106 cells/rat after 72 hours of CCl4 injection without receiving any immunosuppressant. After (6 and 8 weeks) of transplantation, blood samples were collected to assess liver functions (ALT, AST, GGT and ALB) and level of Procollagen III as a liver fibrosis marker. In addition, hepatic tissue regeneration was assessed histopathologically and immunohistochemically using antihuman monoclonal antibodies against CD34, CK19 and albumin. Results: Biochemical and histopathological analysis showed significantly increased recovery from liver damage in the transplanted group. In addition, HUCB stem cells transdifferentiated into functional hepatocytes in rats with hepatic injury which results in improving liver structure and function. Conclusion: Our findings suggest that transplantation of hUCMSCs may be a novel therapeutic approach for treating liver fibrosis. Therefore, hUCMSCs are a potential option for treatment of liver cirrhosis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=carbon%20tetra%20chloride" title="carbon tetra chloride">carbon tetra chloride</a>, <a href="https://publications.waset.org/abstracts/search?q=liver%20fibrosis" title=" liver fibrosis"> liver fibrosis</a>, <a href="https://publications.waset.org/abstracts/search?q=mesenchymal%20stem%20cells" title=" mesenchymal stem cells"> mesenchymal stem cells</a>, <a href="https://publications.waset.org/abstracts/search?q=rat" title=" rat"> rat</a> </p> <a href="https://publications.waset.org/abstracts/27746/comparative-stem-cells-therapy-for-regeneration-of-liver-fibrosis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/27746.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">342</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1454</span> Comparison between Transient Elastography (FibroScan) and Liver Biopsy for Diagnosis of Hepatic Fibrosis in Chronic Hepatitis C Genotype 4</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Gamal%20Shiha">Gamal Shiha</a>, <a href="https://publications.waset.org/abstracts/search?q=Seham%20Seif"> Seham Seif</a>, <a href="https://publications.waset.org/abstracts/search?q=Shahera%20Etreby"> Shahera Etreby</a>, <a href="https://publications.waset.org/abstracts/search?q=Khaled%20Zalata"> Khaled Zalata</a>, <a href="https://publications.waset.org/abstracts/search?q=Waleed%20Samir"> Waleed Samir</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Transient Elastography (TE; FibroScan®) is a non-invasive technique to assess liver fibrosis. Aim: To compare TE and liver biopsy in hepatitis C virus (HCV) patients, genotype IV and evaluate the effect of steatosis and schistosomiasis on FibroScan. Methods: The fibrosis stage (METAVIR Score) TE, was assessed in 519 patients. The diagnostic performance of FibroScan is assessed by calculating the area under the receiver operating characteristic curves (AUROCs). Results: The cut-off value of ≥ F2 was 8.55 kPa, ≥ F3 was 10.2 kPa and cirrhosis = F4 was 16.3 kPa. The positive predictive value and negative predictive value were 70.1% and 81.7% for the diagnosis of ≥ F2, 62.6% and 96.22% for F ≥ 3, and 27.7% and 100% for F4. No significant difference between schistosomiasis, steatosis degree and FibroScan measurements. Conclusion: Fibroscan could accurately predict liver fibrosis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=chronic%20hepatitis%20C" title="chronic hepatitis C">chronic hepatitis C</a>, <a href="https://publications.waset.org/abstracts/search?q=FibroScan" title=" FibroScan"> FibroScan</a>, <a href="https://publications.waset.org/abstracts/search?q=liver%20biopsy" title=" liver biopsy"> liver biopsy</a>, <a href="https://publications.waset.org/abstracts/search?q=liver%20fibrosis" title=" liver fibrosis"> liver fibrosis</a> </p> <a href="https://publications.waset.org/abstracts/3662/comparison-between-transient-elastography-fibroscan-and-liver-biopsy-for-diagnosis-of-hepatic-fibrosis-in-chronic-hepatitis-c-genotype-4" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/3662.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">409</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1453</span> Investigating the Post-Liver Transplant Complications and Their Management in Children Referred to the Children’s Medical Center</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hosein%20Alimadadi">Hosein Alimadadi</a>, <a href="https://publications.waset.org/abstracts/search?q=Fatemeh%20Farahmand"> Fatemeh Farahmand</a>, <a href="https://publications.waset.org/abstracts/search?q=Ali%20Jafarian"> Ali Jafarian</a>, <a href="https://publications.waset.org/abstracts/search?q=Nasir%20Fakhar"> Nasir Fakhar</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohammad%20Hassan%20Sohouli"> Mohammad Hassan Sohouli</a>, <a href="https://publications.waset.org/abstracts/search?q=Neda%20Raeesi"> Neda Raeesi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Backgroundsː Regarding the important role of liver transplantation as the only treatment in many cases of end-stage liver disease in children, the aim of this study is to investigate the complications of liver transplantation and their management in children referred to the Children's Medical Center. Methods: This study is a cross-sectional study on pediatric patients who have undergone liver transplants in the years 2016 to 2021. The indication for liver transplantation in this population was confirmed by a pediatric gastroenterologist, and a liver transplant was performed by a transplant surgeon. Finally, information about the patient before and after the transplantation was collected and recorded. Results: A total of 53 patients participated in this study, including 25 (47.2%) boys and 28 (52.8%) girls. The most common causes of liver transplantation were cholestatic and metabolic diseases. The most common early complication of liver transplantation in children was acute cellular rejection (ACR) and anastomotic biliary stricture. The most common late complication in these patients was an infection which was observed in 56.6% of patients. Among the drug side effects, neurotoxicity (convulsions) was seen more in patients, and 15.1% of the transplanted patients died. Conclusion: In this study, the most common early complication of liver transplantation in children was ACR and biliary stricture, and the most common late complication was infection. Neurotoxicity (convulsions) was the most common side effect of drugs. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=liver%20transplantation" title="liver transplantation">liver transplantation</a>, <a href="https://publications.waset.org/abstracts/search?q=complication" title=" complication"> complication</a>, <a href="https://publications.waset.org/abstracts/search?q=infection" title=" infection"> infection</a>, <a href="https://publications.waset.org/abstracts/search?q=survival%20rate" title=" survival rate"> survival rate</a> </p> <a href="https://publications.waset.org/abstracts/167205/investigating-the-post-liver-transplant-complications-and-their-management-in-children-referred-to-the-childrens-medical-center" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/167205.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">82</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1452</span> Classifier for Liver Ultrasound Images</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Soumya%20Sajjan">Soumya Sajjan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Liver cancer is the most common cancer disease worldwide in men and women, and is one of the few cancers still on the rise. Liver disease is the 4th leading cause of death. According to new NHS (National Health Service) figures, deaths from liver diseases have reached record levels, rising by 25% in less than a decade; heavy drinking, obesity, and hepatitis are believed to be behind the rise. In this study, we focus on Development of Diagnostic Classifier for Ultrasound liver lesion. Ultrasound (US) Sonography is an easy-to-use and widely popular imaging modality because of its ability to visualize many human soft tissues/organs without any harmful effect. This paper will provide an overview of underlying concepts, along with algorithms for processing of liver ultrasound images Naturaly, Ultrasound liver lesion images are having more spackle noise. Developing classifier for ultrasound liver lesion image is a challenging task. We approach fully automatic machine learning system for developing this classifier. First, we segment the liver image by calculating the textural features from co-occurrence matrix and run length method. For classification, Support Vector Machine is used based on the risk bounds of statistical learning theory. The textural features for different features methods are given as input to the SVM individually. Performance analysis train and test datasets carried out separately using SVM Model. Whenever an ultrasonic liver lesion image is given to the SVM classifier system, the features are calculated, classified, as normal and diseased liver lesion. We hope the result will be helpful to the physician to identify the liver cancer in non-invasive method. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=segmentation" title="segmentation">segmentation</a>, <a href="https://publications.waset.org/abstracts/search?q=Support%20Vector%20Machine" title=" Support Vector Machine"> Support Vector Machine</a>, <a href="https://publications.waset.org/abstracts/search?q=ultrasound%20liver%20lesion" title=" ultrasound liver lesion"> ultrasound liver lesion</a>, <a href="https://publications.waset.org/abstracts/search?q=co-occurance%20Matrix" title=" co-occurance Matrix"> co-occurance Matrix</a> </p> <a href="https://publications.waset.org/abstracts/10244/classifier-for-liver-ultrasound-images" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/10244.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">411</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1451</span> Anethum graveolens Prevents Liver and Kidney Injury, Oxidative Stress and Inflammation in Mice Exposed to Nicotine Perinatally</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Saleh%20N.%20Maodaa">Saleh N. Maodaa</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Perinatal exposure to nicotine imbalances the redox status in newborns. This study investigated the effect of Anethum graveolens (dill) extract on oxidative stress and tissue injury in the liver and kidney of mice newborns exposed to nicotine perinatally. Pregnant mice received nicotine (0.25 mg/kg) on gestational day 12 to day 5 after birth and/or A. graveolens extract on a gestational day 1 to day 15 after birth. Newborn mice exposed to nicotine showed multiple histopathological alterations in the kidney and liver, including inflammatory cell infiltration and degenerative changes. Nicotine exposure increased hepatic and renal reactive oxygen species (ROS), lipid peroxidation, tumor necrosis factor (TNF-_), interleukin-6 (IL-6), and inducible nitric oxide synthase (iNOS) (p < 0.001), and decreased antioxidant defenses (p < 0.001). A. graveolens supplementation significantly prevented liver and kidney injury, suppressed ROS generation (p < 0.001), lipid peroxidation (p < 0.001), and inflammatory response (p < 0.001), and enhanced antioxidant defenses. In addition, A. graveolens upregulated hepatic and renal Nrf2 and HO-1 mRNA and increased HO-1 activity in normal and nicotine-exposed mice. In conclusion, A. graveolens protects against perinatal nicotine-induced oxidative stress, inflammation, and tissue injury in the liver and kidney of newborn mice. A. graveolens upregulated hepatic and renal Nrf2/HO-1 signaling and enhanced antioxidant defenses in mice. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=dill" title="dill">dill</a>, <a href="https://publications.waset.org/abstracts/search?q=oxidative%20stress" title=" oxidative stress"> oxidative stress</a>, <a href="https://publications.waset.org/abstracts/search?q=cytokines" title=" cytokines"> cytokines</a>, <a href="https://publications.waset.org/abstracts/search?q=nicotine" title=" nicotine"> nicotine</a> </p> <a href="https://publications.waset.org/abstracts/159904/anethum-graveolens-prevents-liver-and-kidney-injury-oxidative-stress-and-inflammation-in-mice-exposed-to-nicotine-perinatally" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/159904.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">80</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1450</span> Evaluation of Tumor-Infiltrating Lymphocytes in Breast Carcinoma: Correlation with Molecular Subtypes and Clinicopathological Parameters</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Arundhathi%20S.">Arundhathi S.</a>, <a href="https://publications.waset.org/abstracts/search?q=Poongodi%20R."> Poongodi R.</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Tumor-infiltrating lymphocytes (TILs) are indicative of the local immune response against tumor proliferation and metastasis. Emerging as a significant marker of immune reactivity, TILs are utilized to evaluate prognostic outcomes across various malignancies, including colon, ovarian, lung, bladder, and breast cancers. In breast cancer (BC), TILs are particularly relevant for assessing tumor response to therapy in both adjuvant and neoadjuvant settings, with a prominent role in triple-negative breast cancer (TNBC), where they have been associated with improved outcomes. As such, TILs are recognized as an independent marker of favorable prognosis in several tumor types, underscoring their potential as a tool in personalized cancer therapy. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=breast%20cancer" title="breast cancer">breast cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=intratumoral%20TIL" title=" intratumoral TIL"> intratumoral TIL</a>, <a href="https://publications.waset.org/abstracts/search?q=stromal%20TIL" title=" stromal TIL"> stromal TIL</a>, <a href="https://publications.waset.org/abstracts/search?q=tumor%20infiltrating%20lymphocytes" title=" tumor infiltrating lymphocytes"> tumor infiltrating lymphocytes</a> </p> <a href="https://publications.waset.org/abstracts/194529/evaluation-of-tumor-infiltrating-lymphocytes-in-breast-carcinoma-correlation-with-molecular-subtypes-and-clinicopathological-parameters" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/194529.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">8</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1449</span> MicroRNA Expression Distinguishes Neutrophil Subtypes</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=R.%20I.%20You">R. I. You</a>, <a href="https://publications.waset.org/abstracts/search?q=C.%20L.%20Ho"> C. L. Ho</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20S.%20Dai"> M. S. Dai</a>, <a href="https://publications.waset.org/abstracts/search?q=H.%20M.%20Hung"> H. M. Hung</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20F.%20Yen"> S. F. Yen</a>, <a href="https://publications.waset.org/abstracts/search?q=C.%20S.%20Chen"> C. S. Chen</a>, <a href="https://publications.waset.org/abstracts/search?q=T.%20Y.%20Chao"> T. Y. Chao</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Neutrophils are the most abundant innate immune cells to against invading microorganisms. Numerous data shown neutrophils have plasticity in response to physiological and pathological conditions. Tumor-associated neutrophils (TAN) exist in distinct types of tumor and play an important role in cancer biology. Different transcriptomic profiles of neutrophils in tumor and non-tumor samples have been identified. Several miRNAs have been recognized as regulators of gene expression in neutrophil, which may have key roles in neutrophil activation. However, the miRNAs expression patterns in TAN are not well known. To address this question, magnetic bead isolated neutrophils from tumor-bearing mice were used in this study. We analyzed production of reactive oxygen species (ROS) by luminol-dependent chemiluminescence assay. The expression of miRNAs targeting NADPH oxidase, ROS generation and autophagy was explored using quantitative real-time polymerase chain reaction. Our data suggest that tumor environment influence neutrophil develop to differential states of activation via miRNAs regulation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=tumor-associated%20neutrophil" title="tumor-associated neutrophil">tumor-associated neutrophil</a>, <a href="https://publications.waset.org/abstracts/search?q=miRNAs" title=" miRNAs"> miRNAs</a>, <a href="https://publications.waset.org/abstracts/search?q=neutrophil" title=" neutrophil"> neutrophil</a>, <a href="https://publications.waset.org/abstracts/search?q=ROS" title=" ROS "> ROS </a> </p> <a href="https://publications.waset.org/abstracts/13682/microrna-expression-distinguishes-neutrophil-subtypes" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/13682.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge 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