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whitepaper"> <div class="hero resources-hero" style="background-image: url(https://somalogic.com/wp-content/uploads/2023/07/CV_whitePaper_Hero_Final-scaled.jpg);height: 768px;" title="Hero image of lab samples"> <div class="container"> <div class="grid"> <div class="cell-md-8 pr-40"> <p class="breadcrumbs"><a href="/">Home</a> / Life Science Research / Resources / White Papers / <span class="blue"><span class="blue">Ensuring Reproducibility in Proteomics: Why Coefficient of Variation Is a Critical Metric</span></span></p> <h1>Ensuring reproducibility in proteomics: Why coefficient of variation is a critical metric</h1> </div> <div class="cell-md-3 cell-offset-md-1 pl-40"> <a href="" class="thumbnail" target="_blank"><img src="https://somalogic.com/wp-content/uploads/2023/07/CV_White_Paper_Thumbnail.jpg" alt="image of the white paper"/></a> <div class="share"> <a 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The platform is powered by chemically modified DNA aptamers called SOMAmer® Reagents. SOMAmer Reagents consist of short single-stranded DNA sequences that incorporate hydrophobic modifications, greatly expanding the physiochemical diversity of the large randomized nucleic acid libraries from which the SOMAmer Reagents are selected. The performance metrics for all SOMAmer Reagents in human serum and plasma are provided via the SomaScan Assay online menu tool at <a href="https://menu.somalogic.com" target="_blank" rel="noopener">menu.somalogic.com</a>. Although SomaLogic’s core features (high specificity, sensitivity, and reproducibility) are the main reasons the SomaScan Platform is utilized from biomarker discovery to clinical diagnosis, the power of its low coefficients of variation (CVs) is underappreciated. The SomaScan Assay has maintained a median CV of ~5%, which results in the ability to detect smaller biological changes with higher study power compared to other proteomic technologies. The following discussion captures the vast benefits of low CVs, as well as the specific value of the unrivaled SomaScan Platform CVs.</p> </div> </div><div class="text-block cell-md-12 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="mt-60 a-center"><h2>Click below for a downloadable version of this white paper</h2> <p><a href="https://share.hsforms.com/1gEuQWp-qS7O_0EmFBZndxA3zbc6" target="_blank" class="btn blue">Download white paper</a></p> </div> </div></div> </div> </div> <div class="wrap black separator"> <div class="container"> <div class="grid"> </div> </div> </div> <div class="wrap white"> <div class="container"> <div class="grid"> <div class="cell-md-12"> <h2 class="a-center">More White Papers</h2> <div class="cards"> <div class="card white-bg resource-card" style="background-image: url(https://somalogic.com/wp-content/uploads/2022/07/iStock-1214057464-scaled-2-768x256.jpg);" title="Graphic of different size circles with lines connecting them"> <div> <div class="content"> <h3><span class="up">White paper</span>The missing link between genes and disease: Discovery of protein quantitative trait loci using high-plex protein profiling</h3> <p></p> </div> <p class="a-center"><a href="https://somalogic.com/white-paper/pqtl-white-paper/" class="btn blue-border">Learn more</a></p> </div> </div><div class="card white-bg resource-card" style="background-image: url(https://somalogic.com/wp-content/uploads/2022/07/bloodBasedLabwork-768x432.jpg);" title="Image of blood based research in lab"> <div> <div class="content"> <h3><span class="up">White paper</span>The SomaScan® Assay enables discovery of blood-based biomarkers in neurodegenerative diseases</h3> <p></p> </div> <p class="a-center"><a href="https://somalogic.com/white-paper/the-somascan-assay-enables-discovery-of-blood-based-biomarkers/" class="btn blue-border">Learn more</a></p> </div> </div><div class="card white-bg resource-card" style="background-image: url(https://somalogic.com/wp-content/uploads/2022/07/iStock-1209742435-1-scaled-1-768x432.jpg);" title="Image of a design/graphic of virus"> <div> <div class="content"> <h3><span class="up">White paper</span>COVID-19 and the SomaScan® Platform</h3> <p></p> </div> <p class="a-center"><a href="https://somalogic.com/white-paper/infectious-disease-whitepaper/" class="btn blue-border">Learn more</a></p> </div> </div> </div> <p class="a-center mt-60"><a href="/publications/" class="btn blue">Explore external publications in our interactive viewer</a></p> </div> </div> </div> </div></main> <footer> <div class="footer-top"> <div class="container"> <div class="grid"> <div class="cell-md-6"> <img src="https://somalogic.com/wp-content/themes/soma/img/SomaLogic-SBI-Dual-Logo-White.svg" alt="Somalogic logo" class="footer-logo" /> <p>SomaLogic Operating Co., Inc.<br /> 2945 Wilderness Pl. 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