Pipeline: NK Cell Therapy for Autoimmune Disease and Cancer

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id="main" class="main"> <section class="section section-hero section-dark-blue _contact"> <div class="bg-holder"> <img class="rellax lazyload" data-rellax-speed="-5" data-src="https://www.artivabio.com/wp-content/uploads/2021/03/icon-logo-gray.svg" alt="description" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw=="><noscript><img class="rellax" data-rellax-speed="-5" src="https://www.artivabio.com/wp-content/uploads/2021/03/icon-logo-gray.svg" alt="description"></noscript> </div> <div class="container"> <h1 data-aos="fade" data-aos-delay="700" data-aos-duration="3000">NK Cell Therapies</h1> </div> </section> <section id="unlocking" class="section section-white"> <div class="container"> <h2 class="text-center " data-aos="fade" data-aos-duration="3000" data-aos-delay="700">Artiva's NK Cell Therapy Pipeline </h2> <div class="big-container table-holder" id="tablet-holder">  <div id="supsystic-table-1_48045" class="supsystic-tables-wrap " style=" width: 100%;" 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data-responsive-mode="0" data-from-history="0">  <thead> <tr> <th class style="width:12.5%; padding: 0 !important;"></th> <th class style="width:12.5%; padding: 0 !important;"></th> <th class style="width:12.5%; padding: 0 !important;"></th> <th class style="width:12.5%; padding: 0 !important;"></th> <th class style="width:12.5%; padding: 0 !important;"></th> <th class style="width:12.5%; padding: 0 !important;"></th> <th class style="width:12.5%; padding: 0 !important;"></th> <th class style="width:12.5%; padding: 0 !important;"></th> </tr> </thead>  <tbody>  <tr> <td data-cell-id="A1" data-x="0" data-y="1" data-db-index="1" class="color-ffffff bg-00225e" data-cell-type="text" data-original-value="Program" data-order="Program">Program</td> <td data-cell-id="B1" data-x="0" data-y="1" data-db-index="1" class="color-ffffff bg-00225e" data-cell-type="text" data-original-value="Target" data-order="Target">Target</td> <td data-cell-id="C1" data-x="0" data-y="1" data-db-index="1" class="color-ffffff bg-00225e" data-cell-type="text" data-original-value="Indication" data-order="Indication">Indication</td> <td data-cell-id="D1" data-x="0" data-y="1" data-db-index="1" class="color-ffffff bg-00225e" data-cell-type="text" data-original-value="Preclinical" data-order="Preclinical">Preclinical</td> <td data-cell-id="E1" data-x="0" data-y="1" data-db-index="1" class="color-ffffff bg-00225e" data-cell-type="text" data-original-value="Phase_1" data-order="Phase_1">Phase 1</td> <td data-cell-id="F1" data-x="0" data-y="1" data-db-index="1" class="color-ffffff bg-00225e" data-cell-type="text" data-original-value="Phase_2" data-order="Phase_2">Phase 2</td> <td data-cell-id="G1" data-x="0" data-y="1" data-db-index="1" class="color-ffffff bg-00225e" data-cell-type="text" data-original-value="Phase_3" data-order="Phase_3">Phase 3</td> <td data-cell-id="H1" data-x="0" data-y="1" data-db-index="1" class="color-ffffff bg-00225e" data-cell-type="text" data-original-value="Partner" data-order="Partner">Partner</td> </tr>   <tr class="title_row"> <td colspan="8" data-cell-id="B2" data-x="1" data-y="2" data-db-index="2" class="color-bd3761 bg-edede5" data-cell-type="text" data-original-value="Artiva-Funded Trials" data-order="Artiva-Funded Trials" data-colspan="4" data-rowspan="1"> Artiva-Funded Trials</td> </tr> <tr class=""> <td data-cell-id="C2" data-x="2" data-y="2" data-db-index="2" class="" data-cell-type="text" data-original-value="AlloNK庐"> <a href='#AlloNK-Rituximab'> AlloNK庐 </a> </td> <td data-cell-id="C3" data-x="2" data-y="3" data-db-index="3" class="" data-cell-type="text" data-original-value="+ Rituximab </br>+ Obinutuzumab"> <a href='#AlloNK-Rituximab'> + Rituximab </br>+ Obinutuzumab </a> </td> <td data-cell-id="C4" data-x="2" data-y="4" data-db-index="4" class="" data-cell-type="text" data-original-value="SLE, LN"> <a href='#AlloNK-Rituximab'> SLE, LN </a> </td> <td data-cell-id="C5" data-x="2" data-y="5" data-db-index="5" class="" data-cell-type="text" data-original-value=""> <a href='#AlloNK-Rituximab' class="arrow-t" style="background-color:#125679;border-color:#125679;width:calc(160% - 20px);"> </a> </td> <td data-cell-id="C6" data-x="2" data-y="6" data-db-index="6" class="" data-cell-type="text" data-original-value=""> <a href='#AlloNK-Rituximab'> </a> </td> <td data-cell-id="C7" data-x="2" data-y="7" data-db-index="7" class="" data-cell-type="text" data-original-value=""> <a href='#AlloNK-Rituximab'> </a> </td> <td data-cell-id="C8" data-x="2" data-y="8" data-db-index="8" class="" data-cell-type="text" data-original-value=""> <a href='#AlloNK-Rituximab'> </a> </td> <td data-cell-id="C9" data-x="2" data-y="9" data-db-index="9" class="" data-cell-type="text" data-original-value=""> <a href='#AlloNK-Rituximab'> </a> </td> </tr> <tr class=""> <td data-cell-id="D2" data-x="3" data-y="2" data-db-index="2" class="" data-cell-type="text" data-original-value="AlloNK庐"> <a href='#AlloNK-IIT'> AlloNK庐 </a> </td> <td data-cell-id="D3" data-x="3" data-y="3" data-db-index="3" class="" data-cell-type="text" data-original-value="+ Rituximab"> <a href='#AlloNK-IIT'> + Rituximab </a> </td> <td data-cell-id="D4" data-x="3" data-y="4" data-db-index="4" class="" data-cell-type="text" data-original-value="IIT(1): RA, PV Vasculitis, (GPA/MPA), SLE"> <a href='#AlloNK-IIT'> IIT(1): RA, PV Vasculitis, (GPA/MPA), SLE </a> </td> <td data-cell-id="D5" data-x="3" data-y="5" data-db-index="5" class="" data-cell-type="text" data-original-value=""> <a href='#AlloNK-IIT' class="arrow-t" style="background-color:#125679;border-color:#125679;width:calc(160% - 20px);"> </a> </td> <td data-cell-id="D6" data-x="3" data-y="6" data-db-index="6" class="" data-cell-type="text" data-original-value=""> <a href='#AlloNK-IIT'> </a> </td> <td data-cell-id="D7" data-x="3" data-y="7" data-db-index="7" class="" data-cell-type="text" data-original-value=""> <a href='#AlloNK-IIT'> </a> </td> <td data-cell-id="D8" data-x="3" data-y="8" data-db-index="8" class="" data-cell-type="text" data-original-value=""> <a href='#AlloNK-IIT'> </a> </td> <td data-cell-id="D9" data-x="3" data-y="9" data-db-index="9" class="" data-cell-type="text" data-original-value=""> <a href='#AlloNK-IIT'> </a> </td> </tr> <tr class=""> <td data-cell-id="E2" data-x="4" data-y="2" data-db-index="2" class="" data-cell-type="text" data-original-value="AlloNK庐"> <a href='#AlloNK-BCell'> AlloNK庐 </a> </td> <td data-cell-id="E3" data-x="4" data-y="3" data-db-index="3" class="" data-cell-type="text" data-original-value="+ Rituximab"> <a href='#AlloNK-BCell'> + Rituximab </a> </td> <td data-cell-id="E4" data-x="4" data-y="4" data-db-index="4" class="" data-cell-type="text" data-original-value="B-Cell Malignancies"> <a href='#AlloNK-BCell'> B-Cell Malignancies </a> </td> <td data-cell-id="E5" data-x="4" data-y="5" data-db-index="5" class="" data-cell-type="text" data-original-value=""> <a href='#AlloNK-BCell' class="arrow-t" style="background-color:#125679;border-color:#125679;width:calc(160% - 20px);"> </a> </td> <td data-cell-id="E6" data-x="4" data-y="6" data-db-index="6" class="" data-cell-type="text" data-original-value=""> <a href='#AlloNK-BCell'> </a> </td> <td data-cell-id="E7" data-x="4" data-y="7" data-db-index="7" class="" data-cell-type="text" data-original-value=""> <a href='#AlloNK-BCell'> </a> </td> <td data-cell-id="E8" data-x="4" data-y="8" data-db-index="8" class="" data-cell-type="text" data-original-value=""> <a href='#AlloNK-BCell'> </a> </td> <td data-cell-id="E9" data-x="4" data-y="9" data-db-index="9" class="" data-cell-type="text" data-original-value=""> <a href='#AlloNK-BCell'> </a> </td> </tr> <tr class="title_row"> <td colspan="8" data-cell-id="F2" data-x="5" data-y="2" data-db-index="2" class="color-bd3761 bg-edede5" data-cell-type="text" data-original-value="Collaborator-Funded Trials" data-order="Collaborator-Funded Trials" data-colspan="4" data-rowspan="1"> Collaborator-Funded Trials</td> </tr> <tr class=""> <td data-cell-id="G2" data-x="6" data-y="2" data-db-index="2" class="" data-cell-type="text" data-original-value="AlloNK庐"> <a href='#AlloNK-AFM13'> AlloNK庐 </a> </td> <td data-cell-id="G3" data-x="6" data-y="3" data-db-index="3" class="" data-cell-type="text" data-original-value="+ Acimtamig"> <a href='#AlloNK-AFM13'> + Acimtamig </a> </td> <td data-cell-id="G4" data-x="6" data-y="4" data-db-index="4" class="" data-cell-type="text" data-original-value="Hodgkin Lymphoma"> <a href='#AlloNK-AFM13'> Hodgkin Lymphoma </a> </td> <td data-cell-id="G5" data-x="6" data-y="5" data-db-index="5" class="" data-cell-type="text" data-original-value=""> <a href='#AlloNK-AFM13' class="arrow-t" style="background-color:#125679;border-color:#125679;width:calc(260% - 20px);"> </a> </td> <td data-cell-id="G6" data-x="6" data-y="6" data-db-index="6" class="" data-cell-type="text" data-original-value=""> <a href='#AlloNK-AFM13'> </a> </td> <td data-cell-id="G7" data-x="6" data-y="7" data-db-index="7" class="" data-cell-type="text" data-original-value=""> <a href='#AlloNK-AFM13'> </a> </td> <td data-cell-id="G8" data-x="6" data-y="8" data-db-index="8" class="" data-cell-type="text" data-original-value=""> <a href='#AlloNK-AFM13'> </a> </td> <td data-cell-id="G9" data-x="6" data-y="9" data-db-index="9" class="" data-cell-type="text" data-original-value="<img alt='description' data-src='https://www.artivabio.com/wp-content/uploads/2022/08/Affimed_Logo_RGB-e1718690852265.png' class='stbSkipLazy alignleft size-full lazyload' src='https://www.artivabio.com/wp-content/uploads/2022/08/Affimed_Logo_RGB-e1718690852265.png' srcset='https://www.artivabio.com/wp-content/uploads/2022/08/Affimed_Logo_RGB-e1718690852265.png 2x'>"> <a href='#AlloNK-AFM13'> <img alt='description' data-src='https://www.artivabio.com/wp-content/uploads/2022/08/Affimed_Logo_RGB-e1718690852265.png' class='stbSkipLazy alignleft size-full lazyload' src='https://www.artivabio.com/wp-content/uploads/2022/08/Affimed_Logo_RGB-e1718690852265.png' srcset='https://www.artivabio.com/wp-content/uploads/2022/08/Affimed_Logo_RGB-e1718690852265.png 2x'> </a> </td> </tr> <tr class=""> <td data-cell-id="H2" data-x="7" data-y="2" data-db-index="2" class="" data-cell-type="text" data-original-value="CAR-NK (AB-201)"> <a href='#CAR-NK-AB-201'> CAR-NK (AB-201) </a> </td> <td data-cell-id="H3" data-x="7" data-y="3" data-db-index="3" class="" data-cell-type="text" data-original-value="HER2"> <a href='#CAR-NK-AB-201'> HER2 </a> </td> <td data-cell-id="H4" data-x="7" data-y="4" data-db-index="4" class="" data-cell-type="text" data-original-value="Solid Tumors"> <a href='#CAR-NK-AB-201'> Solid Tumors </a> </td> <td data-cell-id="H5" data-x="7" data-y="5" data-db-index="5" class="" data-cell-type="text" data-original-value=""> <a href='#CAR-NK-AB-201' class="arrow-t" style="background-color:#125679;border-color:#125679;width:calc(99% - 20px);"> </a> </td> <td data-cell-id="H6" data-x="7" data-y="6" data-db-index="6" class="" data-cell-type="text" data-original-value=""> <a href='#CAR-NK-AB-201'> </a> </td> <td data-cell-id="H7" data-x="7" data-y="7" data-db-index="7" class="" data-cell-type="text" data-original-value=""> <a href='#CAR-NK-AB-201'> </a> </td> <td data-cell-id="H8" data-x="7" data-y="8" data-db-index="8" class="" data-cell-type="text" data-original-value=""> <a href='#CAR-NK-AB-201'> </a> </td> <td data-cell-id="H9" data-x="7" data-y="9" data-db-index="9" class="" data-cell-type="text" data-original-value="<img alt='description' data-src='https://www.artivabio.com/wp-content/uploads/2023/01/gc-cell-1.jpg' class='stbSkipLazy alignleft size-full lazyload' src='https://www.artivabio.com/wp-content/uploads/2023/01/gc-cell-1.jpg' srcset='https://www.artivabio.com/wp-content/uploads/2023/01/gc-cell-1.jpg 2x'>"> <a href='#CAR-NK-AB-201'> <img alt='description' data-src='https://www.artivabio.com/wp-content/uploads/2023/01/gc-cell-1.jpg' class='stbSkipLazy alignleft size-full lazyload' src='https://www.artivabio.com/wp-content/uploads/2023/01/gc-cell-1.jpg' srcset='https://www.artivabio.com/wp-content/uploads/2023/01/gc-cell-1.jpg 2x'> </a> </td> </tr> <tr class=""> <td data-cell-id="I2" data-x="8" data-y="2" data-db-index="2" class="" data-cell-type="text" data-original-value="CAR-NK (AB-205)"> <a href='#CAR-NK-AB-205'> CAR-NK (AB-205) </a> </td> <td data-cell-id="I3" data-x="8" data-y="3" data-db-index="3" class="" data-cell-type="text" data-original-value="CD5"> <a href='#CAR-NK-AB-205'> CD5 </a> </td> <td data-cell-id="I4" data-x="8" data-y="4" data-db-index="4" class="" data-cell-type="text" data-original-value="Hematologic Malignancies"> <a href='#CAR-NK-AB-205'> Hematologic Malignancies </a> </td> <td data-cell-id="I5" data-x="8" data-y="5" data-db-index="5" class="" data-cell-type="text" data-original-value=""> <a href='#CAR-NK-AB-205' class="arrow-t" style="background-color:#125679;border-color:#125679;width:calc(99% - 20px);"> </a> </td> <td data-cell-id="I6" data-x="8" data-y="6" data-db-index="6" class="" data-cell-type="text" data-original-value=""> <a href='#CAR-NK-AB-205'> </a> </td> <td data-cell-id="I7" data-x="8" data-y="7" data-db-index="7" class="" data-cell-type="text" data-original-value=""> <a href='#CAR-NK-AB-205'> </a> </td> <td data-cell-id="I8" data-x="8" data-y="8" data-db-index="8" class="" data-cell-type="text" data-original-value=""> <a href='#CAR-NK-AB-205'> </a> </td> <td data-cell-id="I9" data-x="8" data-y="9" data-db-index="9" class="" data-cell-type="text" data-original-value="<img alt='description' data-src='https://www.artivabio.com/wp-content/uploads/2023/01/gc-cell.jpg' class='stbSkipLazy alignleft size-full lazyload' src='https://www.artivabio.com/wp-content/uploads/2023/01/gc-cell.jpg' srcset='https://www.artivabio.com/wp-content/uploads/2023/01/gc-cell.jpg 2x'>"> <a href='#CAR-NK-AB-205'> <img alt='description' data-src='https://www.artivabio.com/wp-content/uploads/2023/01/gc-cell.jpg' class='stbSkipLazy alignleft size-full lazyload' src='https://www.artivabio.com/wp-content/uploads/2023/01/gc-cell.jpg' srcset='https://www.artivabio.com/wp-content/uploads/2023/01/gc-cell.jpg 2x'> </a> </td> </tr>  </tbody> </table> </div>  </div> <p>Note: Artiva holds ex-APAC rights to all programs. (1) investigator-initiated basket trial (IIT) Abbreviations: lupus nephritis (LN), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), pemphigus vulgaris (PV), anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV), granulomatosis with polyangiitis (GPA) / microscopic polyangiitis (MPA), non-Hodgkin lymphoma (NHL), Hodgkin lymphoma (HL)</p> </div> </section> <section class="section section-gray section-to-top"> <div class="container"> <a href="#block-0" class="to-next"> <span class="icon-arrows"></span> </a> <a style="cursor: pointer;" class="to-anchor scroll_to_table"> <span class="icon-arrows"></span> </a> </div> </section> <section id="AlloNK-Rituximab" class="section section-white section-pipeline"> <div class="container"> <h2 data-aos="fade" data-aos-duration="2000" class="text-center"> AlloNK庐 + Anti-CD20 Monoclonal Antibodies in Lupus Nephritis </h2> <p>Systemic lupus erythematosus (SLE) is a chronic, potentially severe, autoimmune disease characterized by abnormal B-cell function and autoantibody production resulting in a range of clinical manifestations including end organ damage and an increased risk of death. SLE affects an estimated 200,000 patients in the U.S. Lupus nephritis (LN) is a manifestation of SLE reported to affect approximately half of all patients with SLE. LN occurs when autoantibodies affect parts of the kidneys that filter out waste, which can result in swelling, weight gain from fluid retention, elevated blood pressure and urine that appears foamy from excessive protein loss. Despite the availability of potent therapies, approximately 30% do not respond to currently available treatments, and up to 10% of LN patients still progress to end-stage renal disease, requiring dialysis and eventually, a kidney transplant.</p> <p>In April 2024, we began dosing patients in our Phase 1/1b open-label, multi-center clinical trial of AlloNK in combination with rituximab or obinutuzumab in patients with class III or class IV LN who previously failed treatment (ClinicalTrials.gov Identifier: <a href="https://clinicaltrials.gov/study/NCT06265220" target="_blank" rel="noopener">NCT06265220</a>). In July 2024 the inclusion criteria were expanded to include patients with SLE, with or without lupus nephritis. To our knowledge, AlloNK was the first allogeneic, off-the-shelf NK cell therapy candidate to receive Investigational New Drug application (IND) clearance to be administered to a patient with an autoimmune disease in a U.S. clinical trial, and to receive United States Food and Drug Administration (FDA) Fast Track designation in an autoimmune disease. Additionally, to our knowledge AlloNK is the first allogeneic NK cell therapy candidate in the United States to receive IND clearance for a basket trial in autoimmune diseases, and specifically the first to be evaluated in rheumatoid arthritis (RA), pemphigus vulgaris (PV) and the anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) subtypes granultomatosis with polyangiitis (GPA) / microscopic polyangiitis (MPA), which we are exploring through a basket IIT.</p> </div> </section> <section class="section section-gray section-to-top last-arrow"> <div class="container"> <a style="cursor: pointer;" class="to-anchor scroll_to_table"> <span class="icon-arrows"></span> </a> </div> </section> <section class="section section-gray section-to-top"> <div class="container"> <a href="#block-0" class="to-next"> <span class="icon-arrows"></span> </a> <a style="cursor: pointer;" class="to-anchor scroll_to_table"> <span class="icon-arrows"></span> </a> </div> </section> <section id="AlloNK-IIT" class="section section-white section-pipeline"> <div class="container"> <h2 data-aos="fade" data-aos-duration="2000" class="text-center"> AlloNK庐 + Rituximab in Investigator-Initiated Basket Trial </h2> <p>In April 2024, the FDA cleared an IND submitted by IRIS, a large community practice rheumatology clinic in Florida, to conduct a basket ITT to assess the safety, tolerability, and clinical activity of AlloNK in combination with rituximab. The IIT will initially enroll patients with rheumatoid arthritis (RA), pemphigus vulgaris (PV), systemic lupus erythematosus (SLE), and the anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) subtypes granultomatosis with polyangiitis (GPA) / microscopic polyangiitis (MPA).</p> </div> </section> <section class="section section-gray section-to-top last-arrow"> <div class="container"> <a style="cursor: pointer;" class="to-anchor scroll_to_table"> <span class="icon-arrows"></span> </a> </div> </section> <section class="section section-gray section-to-top"> <div class="container"> <a href="#block-0" class="to-next"> <span class="icon-arrows"></span> </a> <a style="cursor: pointer;" class="to-anchor scroll_to_table"> <span class="icon-arrows"></span> </a> </div> </section> <section id="AlloNK-BCell" class="section section-white section-pipeline"> <div class="container"> <h2 data-aos="fade" data-aos-duration="2000" class="text-center"> AlloNK庐 + Anti-CD20 Monoclonal Antibodies in Non-Hodgkin Lymphoma </h2> <p>Our ongoing Phase 1/2 clinical trial (ClinicalTrials.gov Identifier:聽<a href="https://clinicaltrials.gov/ct2/show/NCT04673617" target="_blank" rel="noopener">NCT04673617</a>) is assessing the safety and clinical activity of AlloNK庐 alone and in combination with the anti-CD20 monoclonal antibody, rituximab. The study is enrolling patients with relapsed or refractory B-cell non-Hodgkin lymphoma (NHL) who have progressed beyond two or more prior lines of therapy. We have observed deep B-cell depletion in the periphery and complete responses in heavily pre-treated patients. We believe these preliminary results provide a readthrough to autoimmune disease because efficacy in both diseases appears to be accomplished with a shared mechanism of action involving B-cell depletion in the periphery and in the lymphoid tissues.</p> </div> </section> <section class="section section-gray section-to-top last-arrow"> <div class="container"> <a style="cursor: pointer;" class="to-anchor scroll_to_table"> <span class="icon-arrows"></span> </a> </div> </section> <section id="unlocking" class="section section-white"> <div class="container"> <h2 class="text-center " >Partnered Programs</h2> </div> </section><section class="section section-gray section-to-top"> <div class="container"> <a href="#block-0" class="to-next"> <span class="icon-arrows"></span> </a> <a style="cursor: pointer;" class="to-anchor scroll_to_table"> <span class="icon-arrows"></span> </a> </div> </section> <section id="AlloNK-AFM13" class="section section-white section-pipeline"> <div class="container"> <h2 data-aos="fade" data-aos-duration="2000" class="text-center"> AlloNK庐 + Acimtamig in CD30-Positive Lymphomas </h2> <p><img decoding="async" class="aligncenter size-full wp-image-988 lazyload" data-src="https://www.artivabio.com/wp-content/uploads/2022/08/Affimed_Logo_RGB-e1718690852265.png" alt="" width="400" height="63" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" style="--smush-placeholder-width: 400px; --smush-placeholder-aspect-ratio: 400/63;" /><noscript><img decoding="async" class="aligncenter size-full wp-image-988" src="https://www.artivabio.com/wp-content/uploads/2022/08/Affimed_Logo_RGB-e1718690852265.png" alt="" width="400" height="63" /></noscript><br /> Artiva and Affimed have entered into a聽<a href="https://www.artivabio.com/affimed-and-artiva-biotherapeutics-announce-partnership-to-advance-combination-therapy-of-innate-cell-engager-ice-afm13-and-off-the-shelf-allogeneic-nk-cell-therapy-ab-101/">strategic collaboration</a>聽to jointly develop, manufacture, and commercialize a combination therapy comprised of Artiva鈥檚 AlloNK庐, and Affimed鈥檚 Innate Cell Engager (ICE庐) acimtamig (previously known as AFM13) for the treatment of patients with relapsed/refractory CD30-positive lymphomas. The LuminICE-203 study (ClinicalTrials.gov Identifier:聽<a href="https://www.clinicaltrials.gov/study/NCT05883449" target="_blank" rel="noopener">NCT05883449</a>) is currently enrolling patients with relapsed or refractory classical Hodgkin lymphoma, and Affimed presented initial data from the first seven patients in June 2024.</p> </div> </section> <section class="section section-gray section-to-top "> <div class="container"> <a href="#block-1" class="to-next"> <span class="icon-arrows"></span> </a> <a style="cursor: pointer;" class="to-anchor scroll_to_table"> <span class="icon-arrows"></span> </a> </div> </section> <section id="CAR-NK-AB-201" class="section section-white section-pipeline"> <div class="container"> <h2 data-aos="fade" data-aos-duration="2000" class="text-center"> AB-201: HER2 CAR-NK </h2> <p><img decoding="async" class="aligncenter size-full wp-image-1103 lazyload" data-src="https://www.artivabio.com/wp-content/uploads/2023/01/gc-cell-1.jpg" alt="" width="323" height="91" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" style="--smush-placeholder-width: 323px; --smush-placeholder-aspect-ratio: 323/91;" /><noscript><img decoding="async" class="aligncenter size-full wp-image-1103 lazyload" data-src="https://www.artivabio.com/wp-content/uploads/2023/01/gc-cell-1.jpg" alt="" width="323" height="91" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" style="--smush-placeholder-width: 323px; --smush-placeholder-aspect-ratio: 323/91;" /><noscript><img decoding="async" class="aligncenter size-full wp-image-1103" src="https://www.artivabio.com/wp-content/uploads/2023/01/gc-cell-1.jpg" alt="" width="323" height="91" /></noscript></noscript></p> <p>AB-201 is an allogeneic anti-HER2 CAR-NK cell product candidate, containing a CAR with a proprietary HER2 antigen recognition domain and expressing soluble IL-15. HER2, also known as Human Epidermal Growth Factor Receptor 2 or ErbB2, is a receptor tyrosine kinase that is overexpressed on many solid tumors, such as breast, gastric and esophageal, and bladder cancers. AB-201 has shown specific cytotoxic activity against HER2-positive tumor cells in vitro and anti-tumor activity and tumor infiltration in vivo. AB-201 is designed to bind to a region distinct from other HER2-targeting drugs, such as trastuzumab and pertuzumab<em>. </em>We have received orphan drug designation for AB-201 in the United States.</p> </div> </section> <section class="section section-gray section-to-top "> <div class="container"> <a href="#block-2" class="to-next"> <span class="icon-arrows"></span> </a> <a style="cursor: pointer;" class="to-anchor scroll_to_table"> <span class="icon-arrows"></span> </a> </div> </section> <section id="CAR-NK-AB-205" class="section section-white section-pipeline"> <div class="container"> <h2 data-aos="fade" data-aos-duration="2000" class="text-center"> AB-205: CD5-Directed CAR-NK </h2> <p><img decoding="async" class="aligncenter size-full wp-image-1103 lazyload" data-src="https://www.artivabio.com/wp-content/uploads/2023/01/gc-cell-1.jpg" alt="" width="323" height="91" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" style="--smush-placeholder-width: 323px; --smush-placeholder-aspect-ratio: 323/91;" /><noscript><img decoding="async" class="aligncenter size-full wp-image-1103 lazyload" data-src="https://www.artivabio.com/wp-content/uploads/2023/01/gc-cell-1.jpg" alt="" width="323" height="91" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" style="--smush-placeholder-width: 323px; --smush-placeholder-aspect-ratio: 323/91;" /><noscript><img decoding="async" class="aligncenter size-full wp-image-1103" src="https://www.artivabio.com/wp-content/uploads/2023/01/gc-cell-1.jpg" alt="" width="323" height="91" /></noscript></noscript></p> <p>AB-205 is an allogeneic anti-CD5 CAR-NK cell product candidate, containing a CAR with a CD5 antigen recognition domain and expressing soluble IL-15. CD5 is a T-cell activation marker and negative regulator of TCR signaling expressed on tumor cells in the majority of cases of T-cell lymphoma and leukemia. Our partner, GC Cell, has observed specific cytotoxic activity against CD5-positive T-cell leukemia cell lines, CCRF-CEM and RPMI-8402, with AB-205 in vitro and meaningful anti-tumor activity in vivo.</p> </div> </section> <section class="section section-gray section-to-top "> <div class="container"> <a href="#block-3" class="to-next"> <span class="icon-arrows"></span> </a> <a style="cursor: pointer;" class="to-anchor scroll_to_table"> <span class="icon-arrows"></span> </a> </div> </section> <section id="Publications and Presentations" class="section section-white section-pipeline"> <div class="container"> <h2 data-aos="fade" data-aos-duration="2000" class="text-center"> Publications and Presentations </h2> <p>AB-101, an Allogeneic, Non-Genetically Modified, Natural Killer (NK) Cell Therapy, Evaluated as Monotherapy or in Combination with Rituximab in R/R Non-Hodgkin Lymphoma. Presented at: <a href="https://www.artivabio.com/wp-content/uploads/2023/10/2023_ASCO_AB101-Poster-Presentation_Final_15May23.pdf" target="_blank" rel="noopener">American Society of Clinical Oncology (ASCO) 2023</a>.</p> <p>AFM13 enhances the anti-tumor activity of AB-101 towards CD30<sup>+</sup>聽tumors, conferring tumor growth control聽<i>in vivo. </i>Presented at: <a href="https://www.artivabio.com/wp-content/uploads/2023/10/ICML-2023_AFM13_AB-101_final-1.pdf" target="_blank" rel="noopener">International Conference of Malignant Lymphoma (ICML) 2023</a>.</p> <p>Combinatorial Immunotherapy of Tetravalent Bispecific AFM13 and AB-101 NK Cell Product Confers Tumor Growth Control聽<i>In Vivo. </i>Presented at: <a href="https://www.artivabio.com/wp-content/uploads/2023/10/NK2023_AFM13Artiva-NK-Cells_Poster_final.pdf" target="_blank" rel="noopener">Society for Natural Immunity (NK2023)</a>.</p> <p>Evaluation of AB-101, an Allogeneic Cord Blood-derived Natural Killer (NK) Cell Therapy, as an ADCC Enhancer in Hematologic and Solid Tumors. Presented at: <a href="https://www.artivabio.com/wp-content/uploads/2023/10/2022_SITC_AB101-poster_final-Hi-res.pdf" target="_blank" rel="noopener">Society for Immunotherapy of Cancer (SITC) 2022</a>.</p> <p>Pre-Clinical Efficacy of AB-101, An Allogeneic Cord-Blood Derived Natural Killer (NK) Cell Therapeutic Candidate, in Combination with Anti-CD38 Antibodies in Models of Multiple Myeloma. Presented at: <a href="https://www.artivabio.com/wp-content/uploads/2023/10/AB-101anti-CD38_ASH-2022-Poster_Final.pdf" target="_blank" rel="noopener">American Society of Hematology (ASH) 2022</a>.</p> <p>Development of AB-201, a novel allogeneic anti-HER2-specific CAR-NK cell therapy for the treatment of HER2<sup>+</sup> tumors. Presented at: <a href="https://www.artivabio.com/wp-content/uploads/2023/10/2021_SITC_AB201-poster_final_hires.pdf" target="_blank" rel="noopener">Society for Immunotherapy of Cancer (SITC) 2021</a>.</p> </div> </section> <section class="section section-gray section-to-top "> <div class="container"> <a href="#block-4" class="to-next"> <span class="icon-arrows"></span> </a> <a style="cursor: pointer;" class="to-anchor scroll_to_table"> <span class="icon-arrows"></span> </a> </div> </section> <section id="" class="section section-white section-pipeline"> <div class="container"> <h2 class="text-center dark-headline" style="font-size: 16px;">Expanded Access Policy</h2> <div style="font-size: 12px;">Artiva does not currently have an expanded access program for our investigational products. Expanded access, also known as compassionate use, is a potential pathway for a patient with an immediately life-threatening condition or serious disease to gain access to an investigational drug for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available. We are focused on enrolling and conducting the clinical trials necessary to bring innovative, safe, and effective products to patients as quickly as possible. Participation in one of our clinical trials is the only way to access Artiva鈥檚 investigational products at this time. We encourage patients and healthcare providers interested in our investigational products to learn more about our ongoing studies by visiting <a href="https://clinicaltrials.gov/ct2/results?cond=&term=artiva&cntry=&state=&city=&dist=" target="_blank" rel="noopener">Artiva Clinical Studies</a>. For more information, please contact us at <a href="mailto:info@artivabio.com">info@artivabio.com</a>.</div> </div> </section> <section class="section section-gray section-to-top last-arrow"> <div class="container"> <a style="cursor: pointer;" class="to-anchor scroll_to_table"> <span class="icon-arrows"></span> </a> </div> </section> <section class="section section-dark section-cta"> <div class="container text-center"> <h2 data-aos="fade" data-aos-duration="2000" class="h3">Collaborations and partnerships are key to advancing, accelerating, and accessing life-saving therapies.</h2> </div> </section> </main> </div> <footer class="footer"> <div class="container"> <div class="left-side"> <div class="logo"> <a href="https://www.artivabio.com/"> <img data-src="https://www.artivabio.com/wp-content/uploads/2021/03/bg-Artiva-White-Logo.svg" width="137" alt="" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" class="lazyload"><noscript><img src="https://www.artivabio.com/wp-content/uploads/2021/03/bg-Artiva-White-Logo.svg" width="137" alt=""></noscript> </a> </div> <div class="socials-holder"> <ul class="social"> <li class="social-elem"> <a href="https://twitter.com/artivabio" target="_blank"> <span class="icon-twitter"></span> </a> </li> <li class="social-elem"> <a href="https://www.linkedin.com/company/artiva-biotherapeutics/?viewAsMember=true" target="_blank"> <span class="icon-linkedin"></span> </a> </li> <li class="ftr-contact"> <a href="/contact/">Contact </a> </li> </ul> </div> <div class="links-holder"> <div class="menu-footer-menu-container"><ul id="menu-footer-menu" class="menu"><li id="menu-item-265" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-privacy-policy menu-item-265"><a rel="privacy-policy" href="https://www.artivabio.com/privacy-policy/">Privacy Policy</a></li> <li id="menu-item-431" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-431"><a href="https://www.artivabio.com/terms-of-use/">Terms</a></li> </ul></div> </div> <div class="copy-holder"> <p>漏 Artiva Biotherapeutics, Inc., 2024 </p> </div> </div> <div class="right-side"> <a class="h4" href="https://investors.artivabio.com/resources/investor-email-alerts/default.aspx">Sign up for news updates</a> </div> </div> <a href="#top" class="to-top"> <span class="icon-arrows"></span> </a> </footer> <script type="text/javascript" id="branda-cookie-notice-front-js-extra"> /* <![CDATA[ */ var ub_cookie_notice = {"id":"#branda-cookie-notice","cookie":{"domain":"","name":"Branda_Cookie_Notice_1","path":"\/","secure":"on","timezone":-28800,"value":2592000},"reloading":"off","animation":null,"ajaxurl":"https:\/\/www.artivabio.com\/wp-admin\/admin-ajax.php","logged":"no","user_id":"0","nonce":"6df885dca7"}; /* ]]> */ </script> <script type="text/javascript" src="https://www.artivabio.com/wp-content/plugins/ultimate-branding/inc/modules/front-end/assets/js/cookie-notice-front.js?ver=3.4.8" id="branda-cookie-notice-front-js"></script> <script type="text/javascript" src="https://www.artivabio.com/wp-includes/js/comment-reply.min.js?ver=6.6.2" id="comment-reply-js" async="async" data-wp-strategy="async"></script> <script type="text/javascript" src="https://maps.googleapis.com/maps/api/js?key=AIzaSyCgFC7vMHkPjPNbK9Ih-CtBj0cdmhe52FI&ver=1.0.0" id="am_google_maps-js"></script> <script type="text/javascript" src="https://www.artivabio.com/wp-content/themes/artivabio_wp/markup/assets/js/jquery.main.js?ver=1721249985" id="am_markup-assets-js-jquery-main-js-js"></script> <script type="text/javascript" id="am_markup-assets-js-general-js-js-extra"> /* <![CDATA[ */ var myajax = {"url":"https:\/\/www.artivabio.com\/wp-admin\/admin-ajax.php"}; /* ]]> */ </script> <script type="text/javascript" src="https://www.artivabio.com/wp-content/themes/artivabio_wp/markup/assets/js/general.js?ver=1721249985" id="am_markup-assets-js-general-js-js"></script> <script type="text/javascript" src="https://www.artivabio.com/wp-content/plugins/breeze/assets/js/js-front-end/breeze-lazy-load.min.js?ver=2.1.18" id="breeze-lazy-js"></script> <script type="text/javascript" src="https://www.artivabio.com/wp-content/plugins/wp-smushit/app/assets/js/smush-lazy-load.min.js?ver=3.16.6" id="smush-lazy-load-js"></script> <script type="text/javascript">window.addEventListener("DOMContentLoaded",(e=>{document.querySelectorAll('img[loading="lazy"]').forEach((e=>{e.getBoundingClientRect().top<=window.innerHeight&&(e.loading="eager")}))}));</script><div id="branda-cookie-notice" role="banner" class="ub-position-bottom ub-style-none"><div class="cookie-notice-container"><div class="branda-cn-container"><span id="ub-cn-notice-text" class="branda-cn-column">We use cookies to ensure that we give you the best experience on our website. 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Pipeline: NK Cell Therapy for Autoimmune Disease and Cancer