CINXE.COM

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r.ee.get(this.agentIdentifier).abort(),!1}}}({features:[R,_,_e,Ne,he,N,L,Pe,ke],loaderType:"pro"})})()})();</script> <meta name="keywords" content="" /> <link rel="canonical" href="https://www.novusbio.com/product-type/isotype-controls" /> <title>Isotype Controls: Novus Biologicals</title> <meta name="description" content="Find Isotype Controls all backed by our Guarantee+." /> <meta name="baidu-site-verification" content="xQr2vSIwwB" /> <script id="json-ld" type="application/ld+json">[{"@context":"http://schema.org","@type":"SearchResultsPage","about":[{"@type":"Thing","url":["https://www.novusbio.com/products/igg-isotype-control_ab-108-c"],"name":["Goat IgG Isotype Control [Unconjugated]"],"image":[[{"@type":"ImageObject","caption":"SH-SY5Y human neuroblastoma cell line was stained with Goat Anti-Human/Mouse/RatEphrin-B2 Antigen Affinity-purified Polyclonal Antibody (Catalog #AF496,filled histogram) or Normal Goat IgG Isotype Control Antibody(Catalog # AB-108-C, open histogram), followed by Phycoerythrin-conjugatedAnti-Goat IgG Secondary Antibody (Catalog #F0107).","url":"https://images.novusbio.com/fullsize2/IgG_AB108C_Control_19376.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Decreased macrophage recruitment correlates with decreased angiogenesis.A) Quantification of BrdU incorporation demonstrates that decreased macrophage infiltration does not significantly correlate with a change in epithelial cell proliferation (N.S.\u200a=\u200anot significant). B) Quantification of VWF staining reveals decreased blood vessels associated with epithelial structures in mammary glands from mice treated with B/B and anti-CX3CR1 blocking antibody compared with mice treated with B/B and IgG control antibody. *p<0.05. C, D) Representative images of VWF stained mammary glands from mice treated with B/B and either control IgG antibody (C) or anti-CX3CR1 (D). Green\u200a=\u200aVWF staining, blue\u200a=\u200aDAPI. Arrows indicate VWF-positive structures. Scale bars represent 50 \u00b5M. Results in each figure panel are representative of a minimum of three different mice for each treatment group and genotype. Image collected and cropped by CiteAb from the following open publication (//dx.plos.org/10.1371/journal.pone.0045877), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/ab-108-c_normal-goat-igg-control-8220249504611.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"iFGFR1 activation in vivo promotes recruitment of CX3CR1-positive macrophages.MMTV-iFGFR1 transgenic mice were treated with B/B in order to analyze the population of macrophages that are recruited to the mammary epithelium during early stages of iFGFR1-induced mammary tumorigenesis. A) MMTV-iFGFR1 mice treated with B/B demonstrated an increase in macrophage recruitment after 10 days as indicated by an increased in the number of F4/80 positive cells. MMTV-iFGFR1 mice treated with anti-CX3CR1 in conjunction with B/B demonstrated a reduction in macrophage recruitment at 10 days indicating that iFGFR1 activation is responsible for recruiting a subset of macrophages that express CX3CR1. ***p<0.0001. Error bars represent SEM. B) Representative image of macrophages associated with budding epithelial structures in mammary glands from mice treated with control IgG antibody. C) Representative image of macrophages associated with budding epithelial structures in mammary glands from mice treated with anti-CX3CR1. Red\u200a=\u200aF4/80 staining, blue\u200a=\u200aDAPI. Scale bars represent 50 \u00b5M. Results in each figure panel are representative of a minimum of three different mice for each treatment group and genotype. Image collected and cropped by CiteAb from the following open publication (//dx.plos.org/10.1371/journal.pone.0045877), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/ab-108-c_normal-goat-igg-control-8220249505997.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"iFGFR1 activation in vivo promotes recruitment of CX3CR1-positive macrophages.MMTV-iFGFR1 transgenic mice were treated with B/B in order to analyze the population of macrophages that are recruited to the mammary epithelium during early stages of iFGFR1-induced mammary tumorigenesis. A) MMTV-iFGFR1 mice treated with B/B demonstrated an increase in macrophage recruitment after 10 days as indicated by an increased in the number of F4/80 positive cells. MMTV-iFGFR1 mice treated with anti-CX3CR1 in conjunction with B/B demonstrated a reduction in macrophage recruitment at 10 days indicating that iFGFR1 activation is responsible for recruiting a subset of macrophages that express CX3CR1. ***p<0.0001. Error bars represent SEM. B) Representative image of macrophages associated with budding epithelial structures in mammary glands from mice treated with control IgG antibody. C) Representative image of macrophages associated with budding epithelial structures in mammary glands from mice treated with anti-CX3CR1. Red\u200a=\u200aF4/80 staining, blue\u200a=\u200aDAPI. Scale bars represent 50 \u00b5M. Results in each figure panel are representative of a minimum of three different mice for each treatment group and genotype. Image collected and cropped by CiteAb from the following open publication (//dx.plos.org/10.1371/journal.pone.0045877), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/ab-108-c_normal-goat-igg-control-44202415425093.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Blocking the tissue inhibitor of metalloproteinase type 1 (TIMP-1) in MSC-CM reduced its pro-oligodendroglial activity on cultured aNSCs. Representative immunocytochemical staining of 2\u2032,3\u2032-cyclic-nucleotide 3\u2032-phosphodiesterase (CNPase)- (A) and GFAP-positive (B) cells treated either with control (no antibody), anti-TIMP-1, or immunoglobulin G (IgG) control pre-incubated with alpha -MEM or MSC-CM after 3 days in culture. (C) Quantification of CNPase- and GFAP-positive (D) cell numbers. Number of experiments n = 4. Statistical significance was calculated using a two-way ANOVA with Bonferroni posttest: * p \u2264 0.05, ** p \u2264 0.01, *** p \u2264 0.001. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/32570968), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/ab-108-c_normal-goat-igg-control-22820241721182.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Localisation of Sox17 staining in proliferative and secretory phase endometrial tissue and regulation by hormones. Within the proliferative (A) and secretory (B) endometrium, Sox17 localized to the glandular (open arrowheads) and luminal (closed arrowheads) epithelium, with staining appearing in an irregular, patchy, pattern. Smaller inset boxes show relevant IgG negative controls. Imaged at 20x magnification, scale bar = 50 \u03bcm. Treatment of endometrial luminal epithelial (ECC-1) cells with 10\u22128 M estrogen (estradiol)/10\u22127 M progesterone (medroxyprogesterone acetate) (, *p < 0.05) resulted in an upregulation of Sox17 protein, when compared to untreated, estradiol only (\u25a0, E) treatment groups. (C,D) Data presented as mean \u00b1 SEM, n = 5. Representative Western immunoblot shown. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/31664088), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/ab-108-c_normal-goat-igg-control-22820241715316.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Knockdown of SOX17 results in reduced expression in endometrial luminal epithelial cells. Transfection of ECC-1 cells with a CRISPR/Cas9 SOX17 knock down plasmid resulted in decreased SOX17 expression (KD1-5) when compared to untransfected control ECC-1 cells (ECC-1) and ECC-1 cells transfected with a control plasmid (CP). Analysed by Western immunoblot, representative blot shown. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/31664088), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/ab-108-c_normal-goat-igg-control-22820241721177.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Osteoclast resorption of bony interspinous ligaments releases active TGF-beta to drive the progression of ossification in AS patients. e Immunostaining and f quantitative analysis of CD68-positive cells (brown) in the normal and HO-formed interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panel); 25 \u03bcm (bottom panel). Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/ab-108-c_normal-goat-igg-control-22820241795617.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Progression of endochondral heterotopic ossification in AS patients. c Immunostaining and d quantitative analysis of collagen II-positive cells (brown) in the normal and chondrogenic interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panels); 25 \u03bcm (bottom panels). Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/ab-108-c_normal-goat-igg-control-22820241795615.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Chondrocyte differentiation and cartilage formation in interspinous ligaments of AS patients before calcification. a Hematoxylin and eosin (H&E) staining and b Safranin O\u2013Fast Green (SOFG) staining of normal and chondrogenic interspinous ligaments. In the AS group, the right panels show magnified views of the boxed area in the left panels. Scale bar: 100 \u03bcm (two panels on the right side); 25 \u03bcm (left panel). c Immunostaining and d quantitative analysis of collagen II-positive cells (brown) in the normal and chondrogenic interspinous ligaments (sagittal view). The bottom panels show a magnified view of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panel); 25 \u03bcm (bottom panel). e Immunostaining and f quantitative analysis of pSmad2/3-positive cells (brown) in the normal and chondrogenic interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panel); 25 \u03bcm (bottom panel). g Immunostaining and h quantitative analysis of pSmad1/5/8-positive cells (brown) in the normal and inflammatory interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panels); 25 \u03bcm (bottom panels). C, cartilage; L, ligament Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/ab-108-c_normal-goat-igg-control-22820241795614.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Progression of endochondral heterotopic ossification in AS patients. i Immunostaining and j quantitative analysis of pSmad2/3-positive cells (brown) in the normal ligaments and endochondral-ossified interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panel); 25 \u03bcm (bottom panel). k Immunostaining and l quantitative analysis of Osterix-positive cells (brown) in the normal and endochondral-ossified interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panel); 25 \u03bcm (bottom panel). m Immunostaining and n quantitative analysis of pSmad1/5/8-positive cells (brown) in the normal and inflammatory interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panels); 25 \u03bcm (bottom panels). B, bone; BM, bone marrow; C, cartilage Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/ab-108-c_normal-goat-igg-control-22820241795611.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Chondrocyte differentiation and cartilage formation in interspinous ligaments of AS patients before calcification. a Hematoxylin and eosin (H&E) staining and b Safranin O\u2013Fast Green (SOFG) staining of normal and chondrogenic interspinous ligaments. In the AS group, the right panels show magnified views of the boxed area in the left panels. Scale bar: 100 \u03bcm (two panels on the right side); 25 \u03bcm (left panel). c Immunostaining and d quantitative analysis of collagen II-positive cells (brown) in the normal and chondrogenic interspinous ligaments (sagittal view). The bottom panels show a magnified view of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panel); 25 \u03bcm (bottom panel). e Immunostaining and f quantitative analysis of pSmad2/3-positive cells (brown) in the normal and chondrogenic interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panel); 25 \u03bcm (bottom panel). g Immunostaining and h quantitative analysis of pSmad1/5/8-positive cells (brown) in the normal and inflammatory interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panels); 25 \u03bcm (bottom panels). C, cartilage; L, ligament Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/ab-108-c_normal-goat-igg-control-22820241795612.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Elevated TGF-beta levels in the early inflammatory stage of AS. a Hematoxylin and eosin (H&E) staining and b Safranin O\u2013Fast Green (SOFG) staining of normal and inflamed interspinous ligaments. In the AS group, the right panels show magnified views of the boxed area in the left panels. Scale bar: 100 \u03bcm (two panels on the right); 25 \u03bcm (left panel). c Immunostaining and d quantitative analysis of CD68-positive cells (brown) in the normal and inflamed interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panels); 25 \u03bcm (bottom panels). e Immunostaining and f quantitative analysis of pSmad2/3-positive cells (brown) in the normal and inflamed interspinous ligaments (sagittal view) in normal ligaments and inflammatory ligaments. The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panels); 25 \u03bcm (bottom panels). g Immunostaining and h quantitative analysis of pSmad1/5/8-positive cells (brown) in the normal and inflamed interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panels); 25 \u03bcm (bottom panels) Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/ab-108-c_normal-goat-igg-control-2282024179566.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Osteoclast resorption of bony interspinous ligaments releases active TGF-beta to drive the progression of ossification in AS patients. g Immunostaining and h quantitative analysis of pSmad2/3-positive cells in the normal and HO-formed interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panel); 25 \u03bcm (bottom panel). i Immunostaining and j quantitative analysis of Osterix-positive cells (brown) in the normal and HO-formed interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panel); 25 \u03bcm (bottom panel).Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/ab-108-c_normal-goat-igg-control-2282024179567.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Progression of endochondral heterotopic ossification in AS patients.g Immunostaining and h quantitative analysis of the number of CD68-positive osteoclast (brown) surface (OCS) per bone surface (BS). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panel); 25 \u03bcm (bottom panel). i Immunostaining and j quantitative analysis of pSmad2/3-positive cells (brown) in the normal ligaments and endochondral-ossified interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panel); 25 \u03bcm (bottom panel). k Immunostaining and l quantitative analysis of Osterix-positive cells (brown) in the normal and endochondral-ossified interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panel); 25 \u03bcm (bottom panel). m Immunostaining and n quantitative analysis of pSmad1/5/8-positive cells (brown) in the normal and inflammatory interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panels); 25 \u03bcm (bottom panels). B, bone; BM, bone marrow; C, cartilage Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/ab-108-c_normal-goat-igg-control-2282024179560.jpg","width":400,"height":400}]]},{"@type":"Thing","url":["https://www.novusbio.com/products/igg1-isotype-control-11711_mab002"],"name":["Mouse IgG1 Isotype Control (11711) [Unconjugated]"],"image":[[{"@type":"ImageObject","caption":"Human peripheral blood mononuclear cells (PBMCs) werestained with Mouse Anti-Human LILRA6/CD85b Monoclonal Antibody (Catalog #MAB8656,filled histogram) or Mouse IgG1 Isotype Control Antibody (Catalog # MAB002, openhistogram), followed by Allophycocyanin-conjugated Anti-Mouse IgG SecondaryAntibody (Catalog # F0101B).","url":"https://images.novusbio.com/fullsize2/IgG1_MAB002_Control_19369.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"EC and PC ICAM-1 expression and effects of CD18 blocking on neutrophil adhesion.ICAM-1 expression on (A) EC or (D) PC monolayers before and after 4 hr IL-1 beta activation was assessed by flow cytometry (IgG labeled control white). ICAM-1 expression on (B,C) EC and (E,F) PC following 4 hr IL-1 beta activation was imaged using confocal microscopy. Scale bars are 20 \u00b5m. (G) Neutrophil adhesion inhibition to IL-1 beta activated EC or PC monolayers. Freshly isolated neutrophils were pre-incubated with anti-Mac-1 or anti-LFA-1 antibodies and seeded onto EC or PC monolayers (activated for 4 with IL-1 beta ) in Sykes-Moore chambers and allowed to adhere prior to counting. Bars represent average neutrophil adhesion \u00b1 SEM. *P<0.05, when compared to the no block control. Image collected and cropped by CiteAb from the following publication (//dx.plos.org/10.1371/journal.pone.0060025), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/mab002_mouse-igg1-isotype-control-clone-11711-41202410484325.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"EC and PC ICAM-1 expression and effects of CD18 blocking on neutrophil adhesion.ICAM-1 expression on (A) EC or (D) PC monolayers before and after 4 hr IL-1 beta activation was assessed by flow cytometry (IgG labeled control white). ICAM-1 expression on (B,C) EC and (E,F) PC following 4 hr IL-1 beta activation was imaged using confocal microscopy. Scale bars are 20 \u00b5m. (G) Neutrophil adhesion inhibition to IL-1 beta activated EC or PC monolayers. Freshly isolated neutrophils were pre-incubated with anti-Mac-1 or anti-LFA-1 antibodies and seeded onto EC or PC monolayers (activated for 4 with IL-1 beta ) in Sykes-Moore chambers and allowed to adhere prior to counting. Bars represent average neutrophil adhesion \u00b1 SEM. *P<0.05, when compared to the no block control. Image collected and cropped by CiteAb from the following publication (//dx.plos.org/10.1371/journal.pone.0060025), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/mab002_mouse-igg1-isotype-control-clone-11711-41202410484329.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"miR-720 maintains the migratory and invasive properties of MDA-MB-231 cells. MDA-MB-231 cells were transfected with 50 nM anti-miR-720 or anti-miR-negative control (Ctrl) for 48\u00a0h. Either RNA was isolated (a) or transfected cells subjected to functional assays (b\u2013e). a miR-720 levels. RNA was subjected to RT-qPCR for miR-720. Control condition (Ctrl) was set to 1.0 (mean\u2009\u00b1\u2009SD from three independent experiments). b Migration assay. Transfected cells were subjected to a migration assay in a Boyden chamber over a 24-h period. The cells that migrated through the chamber were quantified using crystal violet staining. Ctrl was set to 100\u00a0% (mean\u2009\u00b1\u2009SD from three independent experiments). c Matrigel assay. Transfected cells were grown in Matrigel for 11\u201315 days and then photographed using a Nikon eclipse TS100 microscope at 10\u00d7 magnification. Scale bar\u2009=\u2009100\u00a0\u03bcm. Representative images of two independent experiments with similar results are shown (left panels). The number of branched colonies were counted. The count in the control sample was set to 1.0 (right panel). d Transendothelial migration assay. Transfected MDA-MB-231 cells were plated in a Boyden chamber that had been coated with a confluent monolayer of HUVEC cells, and the cancer cells that invaded through the HUVEC layer over a 24-h period were quantified using crystal violet staining. Ctrl value for transendothelial (transendo.) migration was set to 100\u00a0% (mean\u2009\u00b1\u2009SD from three independent experiments) and relative (Rel.) migration values given. e ATP assay. Transfected cells were grown for 24\u00a0h and ATP levels were measured using an ATPlite 1Step assay. Ctrl was set to 100\u00a0% (mean\u2009\u00b1\u2009SD from three independent experiments). *P\u2009<\u20090.05, ***P\u2009<\u20090.001, Student\u2019s t test. Not sig. not significant Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/27039296), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/mab002_mouse-igg1-isotype-control-clone-11711-4120241048247.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Monoclonal ASM antibody (23A12C3) inhibits pathogenic Th17 cell differentiation and protects neuropathological features in APP/PS1 mice. e Representative flow cytometry plot and graph displaying the calculated percentage and mean fluorescent intensity of Th17 cells (CD4+ IL17A+) differentiated from CD4+ T cell in each group (Control, n = 5; Smpd1ox/ox serum/con IgG ab, n = 10; Smpd1ox/ox serum/23A12C3, n = 8). f Western blotting for p-Stat3, p-JNK, p-AKT, p-mTOR in Th17 cells differentiated from CD4+ T cell in each group (n = 4/group). g ASM activity in plasma (n = 5/group). h Percentage of Th17 cells in the spleen, blood, and brain by flow cytometry (n = 5/group). i Quantification of microglia (Iba-1) and astrocyte (GFAP) (n = 5/group). j mRNA levels of inflammatory markers in the cortex and hippocampus (n = 4/group). k Representative immunofluorescence images and quantification of ThioS (A beta plaques) in cortex and hippocampus. Scale bars, 50 \u03bcm. (n = 5/group). l Quantification of 6E10 (n = 5/group). m The results of Morris water maze test (n = 10/group). n, o At probe trial day 11, time spent in target platform (n) and the number of times each animal entered the small target zone (o) were analyzed (n = 10/group). p The results of fear-conditioning test (n = 10/group). d\u2013j, m\u2013p One-way analysis of variance, Tukey\u2019s post hoc test. k, l, n Two-tailed student\u2019s t test. All error bars indicate s.e.m. All in vivo data analysis was done at 9-mo-old mice. Source data are provided as a Source Data file. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/36959217), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/mab002_mouse-igg1-isotype-control-clone-11711-22820241721173.jpg","width":400,"height":400}]]},{"@type":"Thing","url":["https://www.novusbio.com/products/igg2a-isotype-control-54447_mab006"],"name":["Rat IgG2a Isotype Control (54447) [Unconjugated]"],"image":[[{"@type":"ImageObject","caption":"B16-F1 mouse melanoma cell line was stained with RatAnti-Mouse Integrin beta 1/CD29 Monoclonal Antibody (Catalog # MAB2405,filled histogram) or Rat IgG Isotype Control Antibody (Catalog #MAB006,open histogram), followed by Phycoerythrin-conjugated Anti-Rat IgG SecondaryAntibody (Catalog # F0105B).","url":"https://images.novusbio.com/fullsize2/IgG2A_MAB006_Control_19425.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"CCL17-mediated chemotaxis is inhibited in a dose-dependent manner by B202 and B225.EL4 cells were incubated with mouse CCL17 at 2/mL in the presence and absence of (A) B202, (B) B225 (C) CNTO 5516 which is an irrelevant rat:mouse chimeric antibody having a mouse IgG1 Fc or (D) MAB529 (rat antibody) which is a commercial antibody that neutralizes CCL17. Assay was repeated twice with five replicates per sample each time. Data are expressed as chemotactic index (CI\u200a=\u200aAverage RLU from stimulated wells/average RLU from medium control; medium control\u200a=\u200aCI of 1). Antibody dose used for each sample is indicated along the x axis. Composite CI results from both experiments are shown. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/24339934), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/mab006_rat-igg2a-isotype-control-clone-54447-41202412514850.jpg","width":400,"height":400}]]},{"@type":"Thing","url":["https://www.novusbio.com/products/igg-isotype-control_ab-105-c"],"name":["Rabbit IgG Isotype Control [Unconjugated]"],"image":[[{"@type":"ImageObject","caption":"HepG2 human hepatocellular carcinoma cell line was stained with Rabbit Anti-Human Klotho beta Monoclonal Antibody (Catalog # MAB58891, filled histogram) or Rabbit IgG Isotype Control Antibody (Catalog # AB-105-C, open histogram), followed by Allophycocyanin-conjugated Anti-Rabbit IgG Secondary Antibody (Catalog # F0111). View our protocol for Staining Membrane-associated Proteins.","url":"https://images.novusbio.com/fullsize2/IgG_AB105C_Control_20512.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"pSTAT5, but not NS1, interacts with the MCM complex.(A) Immunoprecipitation (IP) assay. Cell lysates of NS1Flag-expressing UT7/Epo-S1 cells were prepared for pull-down assays with either anti-Flag-conjugated beads or control beads. Immunoprecipitated proteins were examined for the presence of MCM2 by Western blotting. Blots were reprobed with rabbit anti-pSTAT5(Y694), anti-E2F5, and anti-Flag antibodies. Detection of E2F5 was used as a positive control for NS1 IP. (B) Co-IP assay. UT7/Epo-S1 cells were collected, washed, and lysed with RIPA buffer. After centrifugation, the supernatant was incubated with either rabbit anti-pSTAT5(Y694) or control IgG antibody. Immunoprecipitated proteins were blotted for the presence of the MCM complex with an anti-MCM5 antibody and for pSTAT5 with rabbit anti-pSTAT5(Y694). (C) Reverse Co-IP assay. Reverse Co-IP was performed with an anti-MCM5 antibody. Immunoprecipitated proteins were examined for pSTAT5, MCM2, and MCM5, respectively. (D) Co-IP of lysates treated with DNase. UT7/Epo-S1 cell lysates, either treated or untreated with DNase (750 units of Benzonase) were incubated with anti-pSTAT5(Y694) or control IgG antibodies for Co-IP assay, and immunoprecipitated proteins were examined for MCM2 by Western blot analysis. (E-H) Immunofluorescence analysis. (E&F) Mock- or B19V-infected CD36+ EPCs were co-stained with rabbit anti-STAT5 and mouse anti-MCM2 antibodies, followed by (E) incubation with respective secondary antibodies, or by (F) proximal ligation assay, which produces amplified signal for labeled molecules in close proximity. (G) CD36+ EPCs were incubated with either DMSO or pimozide (at 30 \u03bcM) for 2 days. And then the cells were co-stained with rabbit anti-STAT5 and mouse anti-MCM2 antibodies for proximity ligation assay. (H) Infected EPCs were stained with an anti-capsid antibody. Confocal images were taken with an Eclipse C1 Plus (Nikon) microscope at 100 \u00d7 magnification. Image collected and cropped by CiteAb from the following open publication (//dx.plos.org/10.1371/journal.ppat.1006370), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/ab-105-c_normal-rabbit-igg-control-8220249504630.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"pSTAT5, but not NS1, interacts with the MCM complex.(A) Immunoprecipitation (IP) assay. Cell lysates of NS1Flag-expressing UT7/Epo-S1 cells were prepared for pull-down assays with either anti-Flag-conjugated beads or control beads. Immunoprecipitated proteins were examined for the presence of MCM2 by Western blotting. Blots were reprobed with rabbit anti-pSTAT5(Y694), anti-E2F5, and anti-Flag antibodies. Detection of E2F5 was used as a positive control for NS1 IP. (B) Co-IP assay. UT7/Epo-S1 cells were collected, washed, and lysed with RIPA buffer. After centrifugation, the supernatant was incubated with either rabbit anti-pSTAT5(Y694) or control IgG antibody. Immunoprecipitated proteins were blotted for the presence of the MCM complex with an anti-MCM5 antibody and for pSTAT5 with rabbit anti-pSTAT5(Y694). (C) Reverse Co-IP assay. Reverse Co-IP was performed with an anti-MCM5 antibody. Immunoprecipitated proteins were examined for pSTAT5, MCM2, and MCM5, respectively. (D) Co-IP of lysates treated with DNase. UT7/Epo-S1 cell lysates, either treated or untreated with DNase (750 units of Benzonase) were incubated with anti-pSTAT5(Y694) or control IgG antibodies for Co-IP assay, and immunoprecipitated proteins were examined for MCM2 by Western blot analysis. (E-H) Immunofluorescence analysis. (E&F) Mock- or B19V-infected CD36+ EPCs were co-stained with rabbit anti-STAT5 and mouse anti-MCM2 antibodies, followed by (E) incubation with respective secondary antibodies, or by (F) proximal ligation assay, which produces amplified signal for labeled molecules in close proximity. (G) CD36+ EPCs were incubated with either DMSO or pimozide (at 30 \u03bcM) for 2 days. And then the cells were co-stained with rabbit anti-STAT5 and mouse anti-MCM2 antibodies for proximity ligation assay. (H) Infected EPCs were stained with an anti-capsid antibody. Confocal images were taken with an Eclipse C1 Plus (Nikon) microscope at 100 \u00d7 magnification. Image collected and cropped by CiteAb from the following open publication (//dx.plos.org/10.1371/journal.ppat.1006370), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/ab-105-c_normal-rabbit-igg-control-822024950325.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"pSTAT5, but not NS1, interacts with the MCM complex.(A) Immunoprecipitation (IP) assay. Cell lysates of NS1Flag-expressing UT7/Epo-S1 cells were prepared for pull-down assays with either anti-Flag-conjugated beads or control beads. Immunoprecipitated proteins were examined for the presence of MCM2 by Western blotting. Blots were reprobed with rabbit anti-pSTAT5(Y694), anti-E2F5, and anti-Flag antibodies. Detection of E2F5 was used as a positive control for NS1 IP. (B) Co-IP assay. UT7/Epo-S1 cells were collected, washed, and lysed with RIPA buffer. After centrifugation, the supernatant was incubated with either rabbit anti-pSTAT5(Y694) or control IgG antibody. Immunoprecipitated proteins were blotted for the presence of the MCM complex with an anti-MCM5 antibody and for pSTAT5 with rabbit anti-pSTAT5(Y694). (C) Reverse Co-IP assay. Reverse Co-IP was performed with an anti-MCM5 antibody. Immunoprecipitated proteins were examined for pSTAT5, MCM2, and MCM5, respectively. (D) Co-IP of lysates treated with DNase. UT7/Epo-S1 cell lysates, either treated or untreated with DNase (750 units of Benzonase) were incubated with anti-pSTAT5(Y694) or control IgG antibodies for Co-IP assay, and immunoprecipitated proteins were examined for MCM2 by Western blot analysis. (E-H) Immunofluorescence analysis. (E&F) Mock- or B19V-infected CD36+ EPCs were co-stained with rabbit anti-STAT5 and mouse anti-MCM2 antibodies, followed by (E) incubation with respective secondary antibodies, or by (F) proximal ligation assay, which produces amplified signal for labeled molecules in close proximity. (G) CD36+ EPCs were incubated with either DMSO or pimozide (at 30 \u03bcM) for 2 days. And then the cells were co-stained with rabbit anti-STAT5 and mouse anti-MCM2 antibodies for proximity ligation assay. (H) Infected EPCs were stained with an anti-capsid antibody. Confocal images were taken with an Eclipse C1 Plus (Nikon) microscope at 100 \u00d7 magnification. Image collected and cropped by CiteAb from the following open publication (//dx.plos.org/10.1371/journal.ppat.1006370), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/ab-105-c_normal-rabbit-igg-control-8220249505941.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Elevated TGF-beta levels in the early inflammatory stage of AS. a Hematoxylin and eosin (H&E) staining and b Safranin O\u2013Fast Green (SOFG) staining of normal and inflamed interspinous ligaments. In the AS group, the right panels show magnified views of the boxed area in the left panels. Scale bar: 100 \u03bcm (two panels on the right); 25 \u03bcm (left panel). c Immunostaining and d quantitative analysis of CD68-positive cells (brown) in the normal and inflamed interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panels); 25 \u03bcm (bottom panels). e Immunostaining and f quantitative analysis of pSmad2/3-positive cells (brown) in the normal and inflamed interspinous ligaments (sagittal view) in normal ligaments and inflammatory ligaments. The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panels); 25 \u03bcm (bottom panels). g Immunostaining and h quantitative analysis of pSmad1/5/8-positive cells (brown) in the normal and inflamed interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panels); 25 \u03bcm (bottom panels) Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/ab-105-c_normal-rabbit-igg-control-22820241721184.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Osteoclast resorption of bony interspinous ligaments releases active TGF-beta to drive the progression of ossification in AS patients. e Immunostaining and f quantitative analysis of CD68-positive cells (brown) in the normal and HO-formed interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panel); 25 \u03bcm (bottom panel). Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/ab-105-c_normal-rabbit-igg-control-22820241723637.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Chondrocyte differentiation and cartilage formation in interspinous ligaments of AS patients before calcification. a Hematoxylin and eosin (H&E) staining and b Safranin O\u2013Fast Green (SOFG) staining of normal and chondrogenic interspinous ligaments. In the AS group, the right panels show magnified views of the boxed area in the left panels. Scale bar: 100 \u03bcm (two panels on the right side); 25 \u03bcm (left panel). c Immunostaining and d quantitative analysis of collagen II-positive cells (brown) in the normal and chondrogenic interspinous ligaments (sagittal view). The bottom panels show a magnified view of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panel); 25 \u03bcm (bottom panel). e Immunostaining and f quantitative analysis of pSmad2/3-positive cells (brown) in the normal and chondrogenic interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panel); 25 \u03bcm (bottom panel). g Immunostaining and h quantitative analysis of pSmad1/5/8-positive cells (brown) in the normal and inflammatory interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panels); 25 \u03bcm (bottom panels). C, cartilage; L, ligament Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/ab-105-c_normal-rabbit-igg-control-22820241721149.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Progression of endochondral heterotopic ossification in AS patients. i Immunostaining and j quantitative analysis of pSmad2/3-positive cells (brown) in the normal ligaments and endochondral-ossified interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panel); 25 \u03bcm (bottom panel). k Immunostaining and l quantitative analysis of Osterix-positive cells (brown) in the normal and endochondral-ossified interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panel); 25 \u03bcm (bottom panel). m Immunostaining and n quantitative analysis of pSmad1/5/8-positive cells (brown) in the normal and inflammatory interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panels); 25 \u03bcm (bottom panels). B, bone; BM, bone marrow; C, cartilage Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/ab-105-c_normal-rabbit-igg-control-22820241723642.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Progression of endochondral heterotopic ossification in AS patients. g Immunostaining and h quantitative analysis of the number of CD68-positive osteoclast (brown) surface (OCS) per bone surface (BS). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panel); 25 \u03bcm (bottom panel). i Immunostaining and j quantitative analysis of pSmad2/3-positive cells (brown) in the normal ligaments and endochondral-ossified interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panel); 25 \u03bcm (bottom panel). k Immunostaining and l quantitative analysis of Osterix-positive cells (brown) in the normal and endochondral-ossified interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panel); 25 \u03bcm (bottom panel). m Immunostaining and n quantitative analysis of pSmad1/5/8-positive cells (brown) in the normal and inflammatory interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panels); 25 \u03bcm (bottom panels). B, bone; BM, bone marrow; C, cartilage Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/ab-105-c_normal-rabbit-igg-control-22820241723648.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Chondrocyte differentiation and cartilage formation in interspinous ligaments of AS patients before calcification. a Hematoxylin and eosin (H&E) staining and b Safranin O\u2013Fast Green (SOFG) staining of normal and chondrogenic interspinous ligaments. In the AS group, the right panels show magnified views of the boxed area in the left panels. Scale bar: 100 \u03bcm (two panels on the right side); 25 \u03bcm (left panel). c Immunostaining and d quantitative analysis of collagen II-positive cells (brown) in the normal and chondrogenic interspinous ligaments (sagittal view). The bottom panels show a magnified view of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panel); 25 \u03bcm (bottom panel). e Immunostaining and f quantitative analysis of pSmad2/3-positive cells (brown) in the normal and chondrogenic interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panel); 25 \u03bcm (bottom panel). g Immunostaining and h quantitative analysis of pSmad1/5/8-positive cells (brown) in the normal and inflammatory interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panels); 25 \u03bcm (bottom panels). C, cartilage; L, ligament Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/ab-105-c_normal-rabbit-igg-control-2282024171534.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Osteoclast resorption of bony interspinous ligaments releases active TGF-beta to drive the progression of ossification in AS patients. g Immunostaining and h quantitative analysis of pSmad2/3-positive cells in the normal and HO-formed interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panel); 25 \u03bcm (bottom panel). i Immunostaining and j quantitative analysis of Osterix-positive cells (brown) in the normal and HO-formed interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panel); 25 \u03bcm (bottom panel). k Immunostaining and l quantitative analysis of PDGF-BB-positive cells in the normal and HO-formed interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panels); 25 \u03bcm (bottom panels). m CD31-positive (red) cells, n EMCN-positive (green) cells and quantification of the fold change of o CD31-positive vessels, p EMCN-positive vessels in the normal and HO-formed interspinous ligaments (sagittal view). q PGP9.5-positive (red) cells and CGRP-positive (green) cells and quantification of the fold change of r PGP9.5 and CGRP double positive nerves in the normal and HO-formed interspinous ligaments (sagittal view). s Immunostaining and t quantitative analysis of pSmad1/5/8-positive cells (brown) in the normal and inflammatory interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panels); 25 \u03bcm (bottom panels) Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/ab-105-c_normal-rabbit-igg-control-22820241721185.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Progression of endochondral heterotopic ossification in AS patients. c Immunostaining and d quantitative analysis of collagen II-positive cells (brown) in the normal and chondrogenic interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panels); 25 \u03bcm (bottom panels). Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/ab-105-c_normal-rabbit-igg-control-22820241721192.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Elevated TGF-beta levels in the early inflammatory stage of AS. a Hematoxylin and eosin (H&E) staining and b Safranin O\u2013Fast Green (SOFG) staining of normal and inflamed interspinous ligaments. In the AS group, the right panels show magnified views of the boxed area in the left panels. Scale bar: 100 \u03bcm (two panels on the right); 25 \u03bcm (left panel). c Immunostaining and d quantitative analysis of CD68-positive cells (brown) in the normal and inflamed interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panels); 25 \u03bcm (bottom panels). e Immunostaining and f quantitative analysis of pSmad2/3-positive cells (brown) in the normal and inflamed interspinous ligaments (sagittal view) in normal ligaments and inflammatory ligaments. The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panels); 25 \u03bcm (bottom panels). g Immunostaining and h quantitative analysis of pSmad1/5/8-positive cells (brown) in the normal and inflamed interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 \u03bcm (top panels); 25 \u03bcm (bottom panels) Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/ab-105-c_normal-rabbit-igg-control-22820241721116.jpg","width":400,"height":400}]]},{"@type":"Thing","url":["https://www.novusbio.com/products/igg2b-isotype-control-20116_mab004"],"name":["Mouse IgG2b Isotype Control (20116) [Unconjugated]"],"image":[[{"@type":"ImageObject","caption":"K562 human chronic myelogenous leukemia cell line wasstained with Mouse Anti-Human ITFG1 Monoclonal Antibody (Catalog #MAB89001,filled histogram) or Mouse IgG Isotype Control Antibody (Catalog #MAB004,open histogram), followed by Allophycocyanin-conjugated Anti-Mouse IgGSecondary Antibody (Catalog # F0101B).","url":"https://images.novusbio.com/fullsize2/IgG2B_MAB004_Control_19430.jpg","width":400,"height":400}]]},{"@type":"Thing","url":["https://www.novusbio.com/products/igg2a-isotype-control-20102_mab003"],"name":["Mouse IgG2a Isotype Control (20102) [Unconjugated]"],"image":[[{"@type":"ImageObject","caption":"Human peripheral blood granulocytes were stained with MouseAnti-HumanCXCR1/IL-8 RA Monoclonal Antibody (Catalog # MAB330,filled histogram) or Mouse IgG Isotype Control Antibody (Catalog # MAB003,open histogram), followed by Phycoerythrin-conjugated Anti-Mouse IgG SecondaryAntibody (Catalog # F0102B).","url":"https://images.novusbio.com/fullsize2/IgG2A_MAB003_Control_19426.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Transmammary transfer of BMP9 and BMP10 blocking Abs leads to abnormal hypervascularization in neonatal retinas.(A\u2013C\u201d) Representative images of fluorescent isolectin B4-stained retinas either from P6 neonates fed for 3 days by dams injected on P3 with PBS (A), control IgG2a/b Abs (B), or BMP9/10 blocking Abs (C\u2013C\u201d). (C\u2019,C\u201d) are higher magnification images of the relevant boxed areas in C. a, artery; v, vein; scale bars, 500\u2009\u03bcm. (D\u2013L) Higher magnification showing retinal vasculature fields between an artery and a vein (Plexus, D\u2013F), or at the front of an artery (G\u2013I) or a vein (J\u2013L) from neonates treated as in (A\u2013C). Scale bars, 100\u2009\u03bcm. (M\u2013O) Scatter plots showing the vascular density on retinal \u2018petals\u2019 at the plexus (M), artery front (N), or vein front (O). Data represent mean\u2009\u00b1\u2009s.e.m. (n\u2009=\u20096 pups per group from 2 dams); ****P\u2009<\u20090.0001, ANOVA and Kruskal-Wallis test. Arrows indicate AVMs, defined as direct shunts between an artery and a vein. Image collected and cropped by CiteAb from the following publication (//www.nature.com/articles/srep37366), licensed under a CC-BY license. 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</div> <div id="search_content" class="grid_12">  </div> <div class="region region-banners"> <div id="block-block-26" class="block block-block"> <div class="content"> <div class="container_12"><a href="https://www.bio-techne.com/account/novus-bio-techne/login?_ga=2.17257593.151271452<br />
5.1724696046-473375462.1712005244" style="margin: 0 10px;" target="_blank"><img alt="Novus Biologicals products are now on bio-techne.com" src="https://images.novusbio.com/design/ready-to-buy-novus-products-login.png" style="height:120px; width:940px" /></a></div> </div> </div> </div> <div> <div class="region region-content"> <div id="block-et-messages-et-messages-block" class="block block-et-messages"> <div class="content"> <span></span> </div> </div> <div id="block-system-main" class="block block-system"> <div class="content"> <div class="grid_4"> <div class="search_filters"> <div class="filter-title">Filter Results<a href="/product-type/isotype-controls" rel="nofollow" class="search_clear_all_facets">Clear All</a></div> <div class="facets_js"><a href="/product-type/isotype-controls?" class="search_clear_link">clear</a><div class="facet_container_category"><h4><span class="facet_logo facet_logo_open"></span> <span class="facet_name">Category</span></h4> <div class="facet_list"> <div class="search_all_category_facets search_category_facets"> <ul><li><input type="radio" name="fc_category" class="facet_input" checked="checked"><a href="/product-type/isotype-controls?category=Isotype%20Controls" rel="nofollow"><span data-facet="Isotype Controls (165)" class="search_facet_name">Isotype Controls <span class=facet_count> (165)</span></span></a></li> </ul> </div> </div> </div><a href="/product-type/isotype-controls?" class="search_clear_link">clear</a><div class="facet_container_protein-target"><h4><span class="facet_logo facet_logo_open"></span> <span class="facet_name">Protein/Target</span></h4> <div class="facet_list"><input type="text" class="facet_category_search" value="Search"> <div class="search_icon"></div><div class="search_top_category_facets search_category_facets"><ul><li><input type="radio" name="fc_common_name" class="facet_input"><a href="/product-type/isotype-controls?common_name=IgG" rel="nofollow"><span data-facet="IgG (39)" class="search_facet_name">IgG<span class=facet_count> (39)</span></span></a></li><li><input type="radio" name="fc_common_name" class="facet_input"><a href="/product-type/isotype-controls?common_name=IgM" rel="nofollow"><span data-facet="IgM (22)" class="search_facet_name">IgM<span class=facet_count> (22)</span></span></a></li><li><input type="radio" name="fc_common_name" class="facet_input"><a href="/product-type/isotype-controls?common_name=IgG1" rel="nofollow"><span data-facet="IgG1 (13)" class="search_facet_name">IgG1<span class=facet_count> (13)</span></span></a></li><li><input type="radio" name="fc_common_name" class="facet_input"><a href="/product-type/isotype-controls?common_name=IgG2b" rel="nofollow"><span data-facet="IgG2b (13)" class="search_facet_name">IgG2b<span class=facet_count> (13)</span></span></a></li><li class="a-z">-------------- All A - Z ---------------</li></ul></div> <div class="search_all_category_facets search_category_facets"> <ul><li><input type="radio" name="fc_common_name" class="facet_input"><a href="/product-type/isotype-controls?common_name=IgA" rel="nofollow"><span data-facet="IgA (2)" class="search_facet_name">IgA<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_common_name" class="facet_input"><a href="/product-type/isotype-controls?common_name=IgA%20Kappa" rel="nofollow"><span data-facet="IgA Kappa (3)" class="search_facet_name">IgA Kappa<span class=facet_count> (3)</span></span></a></li><li><input type="radio" name="fc_common_name" class="facet_input"><a href="/product-type/isotype-controls?common_name=IgA%20Lambda" rel="nofollow"><span data-facet="IgA Lambda (1)" class="search_facet_name">IgA Lambda<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_common_name" class="facet_input"><a href="/product-type/isotype-controls?common_name=IgE" rel="nofollow"><span data-facet="IgE (1)" class="search_facet_name">IgE<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_common_name" class="facet_input"><a href="/product-type/isotype-controls?common_name=IgG" rel="nofollow"><span data-facet="IgG (39)" class="search_facet_name">IgG<span class=facet_count> (39)</span></span></a></li><li><input type="radio" name="fc_common_name" class="facet_input"><a href="/product-type/isotype-controls?common_name=IgG%20F(ab')2" rel="nofollow"><span data-facet="IgG F(ab')2 (1)" class="search_facet_name">IgG F(ab')2<span class=facet_count> (1)</span></span></a></li></ul><ul class="more_facets"><li><input type="radio" name="fc_common_name" class="facet_input"><a href="/product-type/isotype-controls?common_name=IgG%20F(ab)" rel="nofollow"><span data-facet="IgG F(ab) (3)" class="search_facet_name">IgG F(ab)<span class=facet_count> (3)</span></span></a></li><li><input type="radio" name="fc_common_name" class="facet_input"><a href="/product-type/isotype-controls?common_name=IgG%20F(ab)2" rel="nofollow"><span data-facet="IgG F(ab)2 (4)" class="search_facet_name">IgG F(ab)2<span class=facet_count> (4)</span></span></a></li><li><input type="radio" name="fc_common_name" class="facet_input"><a href="/product-type/isotype-controls?common_name=IgG%20Fc" rel="nofollow"><span data-facet="IgG Fc (8)" class="search_facet_name">IgG Fc<span class=facet_count> (8)</span></span></a></li><li><input type="radio" name="fc_common_name" class="facet_input"><a href="/product-type/isotype-controls?common_name=IgG1" rel="nofollow"><span data-facet="IgG1 (13)" class="search_facet_name">IgG1<span class=facet_count> (13)</span></span></a></li><li><input type="radio" name="fc_common_name" class="facet_input"><a href="/product-type/isotype-controls?common_name=IgG1%20Kappa" rel="nofollow"><span data-facet="IgG1 Kappa (5)" class="search_facet_name">IgG1 Kappa<span class=facet_count> (5)</span></span></a></li><li><input type="radio" name="fc_common_name" class="facet_input"><a href="/product-type/isotype-controls?common_name=IgG1%20Kappa%20Light%20Chain" rel="nofollow"><span data-facet="IgG1 Kappa Light Chain (2)" class="search_facet_name">IgG1 Kappa Light Chain<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_common_name" class="facet_input"><a href="/product-type/isotype-controls?common_name=IgG1%20Lambda" rel="nofollow"><span data-facet="IgG1 Lambda (2)" class="search_facet_name">IgG1 Lambda<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_common_name" class="facet_input"><a href="/product-type/isotype-controls?common_name=IgG2" rel="nofollow"><span data-facet="IgG2 (3)" class="search_facet_name">IgG2<span class=facet_count> (3)</span></span></a></li><li><input type="radio" name="fc_common_name" class="facet_input"><a href="/product-type/isotype-controls?common_name=IgG2a" rel="nofollow"><span data-facet="IgG2a (12)" class="search_facet_name">IgG2a<span class=facet_count> (12)</span></span></a></li><li><input type="radio" name="fc_common_name" class="facet_input"><a href="/product-type/isotype-controls?common_name=IgG2a%20Kappa" rel="nofollow"><span data-facet="IgG2a Kappa (2)" class="search_facet_name">IgG2a Kappa<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_common_name" class="facet_input"><a href="/product-type/isotype-controls?common_name=IgG2a%20Kappa%20Light%20Chain" rel="nofollow"><span data-facet="IgG2a Kappa Light Chain (1)" class="search_facet_name">IgG2a Kappa Light Chain<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_common_name" class="facet_input"><a href="/product-type/isotype-controls?common_name=IgG2a%20Lambda" rel="nofollow"><span data-facet="IgG2a Lambda (2)" class="search_facet_name">IgG2a Lambda<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_common_name" class="facet_input"><a href="/product-type/isotype-controls?common_name=IgG2b" rel="nofollow"><span data-facet="IgG2b (13)" class="search_facet_name">IgG2b<span class=facet_count> (13)</span></span></a></li><li><input type="radio" name="fc_common_name" class="facet_input"><a href="/product-type/isotype-controls?common_name=IgG2b%20Kappa" rel="nofollow"><span data-facet="IgG2b Kappa (1)" class="search_facet_name">IgG2b Kappa<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_common_name" class="facet_input"><a href="/product-type/isotype-controls?common_name=IgG2b%20Kappa%20Light%20Chain" rel="nofollow"><span data-facet="IgG2b Kappa Light Chain (2)" class="search_facet_name">IgG2b Kappa Light Chain<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_common_name" class="facet_input"><a href="/product-type/isotype-controls?common_name=IgG2b%20Lambda" rel="nofollow"><span data-facet="IgG2b Lambda (1)" class="search_facet_name">IgG2b Lambda<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_common_name" class="facet_input"><a href="/product-type/isotype-controls?common_name=IgG2c%20Kappa" rel="nofollow"><span data-facet="IgG2c Kappa (1)" class="search_facet_name">IgG2c Kappa<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_common_name" class="facet_input"><a href="/product-type/isotype-controls?common_name=IgG3" rel="nofollow"><span data-facet="IgG3 (7)" class="search_facet_name">IgG3<span class=facet_count> (7)</span></span></a></li><li><input type="radio" name="fc_common_name" class="facet_input"><a href="/product-type/isotype-controls?common_name=IgG3%20Kappa%20Light%20Chain" rel="nofollow"><span data-facet="IgG3 Kappa Light Chain (1)" class="search_facet_name">IgG3 Kappa Light Chain<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_common_name" class="facet_input"><a href="/product-type/isotype-controls?common_name=IgG3%20Lambda" rel="nofollow"><span data-facet="IgG3 Lambda (2)" class="search_facet_name">IgG3 Lambda<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_common_name" class="facet_input"><a href="/product-type/isotype-controls?common_name=IgG4" rel="nofollow"><span data-facet="IgG4 (2)" class="search_facet_name">IgG4<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_common_name" class="facet_input"><a href="/product-type/isotype-controls?common_name=IgM" rel="nofollow"><span data-facet="IgM (22)" class="search_facet_name">IgM<span class=facet_count> (22)</span></span></a></li><li><input type="radio" name="fc_common_name" class="facet_input"><a href="/product-type/isotype-controls?common_name=IgM%20Fab%20Mu" rel="nofollow"><span data-facet="IgM Fab Mu (1)" class="search_facet_name">IgM Fab Mu<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_common_name" class="facet_input"><a href="/product-type/isotype-controls?common_name=IgM%20Heavy%20Chain" rel="nofollow"><span data-facet="IgM Heavy Chain (1)" class="search_facet_name">IgM Heavy Chain<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_common_name" class="facet_input"><a href="/product-type/isotype-controls?common_name=IgM%20Kappa%20Light%20Chain" rel="nofollow"><span data-facet="IgM Kappa Light Chain (3)" class="search_facet_name">IgM Kappa Light Chain<span class=facet_count> (3)</span></span></a></li><li><input type="radio" name="fc_common_name" class="facet_input"><a href="/product-type/isotype-controls?common_name=IgM%20Lambda" rel="nofollow"><span data-facet="IgM Lambda (3)" class="search_facet_name">IgM Lambda<span class=facet_count> (3)</span></span></a></li><li><input type="radio" name="fc_common_name" class="facet_input"><a href="/product-type/isotype-controls?common_name=IgY" rel="nofollow"><span data-facet="IgY (1)" class="search_facet_name">IgY<span class=facet_count> (1)</span></span></a></li> </ul> </div> </div> </div><a href="/product-type/isotype-controls?" class="search_clear_link">clear</a><div class="facet_container_applications"><h4><span class="facet_logo facet_logo_open"></span> <span class="facet_name">Applications</span></h4> <div class="facet_list"><input type="text" class="facet_category_search" value="Search"> <div class="search_icon"></div><div class="search_top_category_facets search_category_facets"><ul><li><input type="checkbox" name="fc_applications" class="facet_input"><a href="/product-type/isotype-controls?applications=ELISA" rel="nofollow"><span data-facet="ELISA (79)" class="search_facet_name">ELISA<span class=facet_count> (79)</span></span></a></li><li><input type="checkbox" name="fc_applications" class="facet_input"><a href="/product-type/isotype-controls?applications=Flow%20Cytometry" rel="nofollow"><span data-facet="Flow Cytometry (73)" class="search_facet_name">Flow Cytometry<span class=facet_count> (73)</span></span></a></li><li><input type="checkbox" name="fc_applications" class="facet_input"><a href="/product-type/isotype-controls?applications=Western%20Blot" rel="nofollow"><span data-facet="Western Blot (67)" class="search_facet_name">Western Blot<span class=facet_count> (67)</span></span></a></li><li><input type="checkbox" name="fc_applications" class="facet_input"><a href="/product-type/isotype-controls?applications=Immunohistochemistry" rel="nofollow"><span data-facet="Immunohistochemistry (63)" class="search_facet_name">Immunohistochemistry<span class=facet_count> (63)</span></span></a></li><li class="a-z">-------------- All A - Z ---------------</li></ul></div> <div class="search_all_category_facets search_category_facets"> <ul><li><input type="checkbox" name="fc_applications" class="facet_input"><a href="/product-type/isotype-controls?applications=Block/Neutralize" rel="nofollow"><span data-facet="Block/Neutralize (4)" class="search_facet_name">Block / Neutralize<span class=facet_count> (4)</span></span></a></li><li><input type="checkbox" name="fc_applications" class="facet_input"><a href="/product-type/isotype-controls?applications=Chromatin%20Immunoprecipitation" rel="nofollow"><span data-facet="Chromatin Immunoprecipitation (3)" class="search_facet_name">Chromatin Immunoprecipitation<span class=facet_count> (3)</span></span></a></li><li><input type="checkbox" name="fc_applications" class="facet_input"><a href="/product-type/isotype-controls?applications=Control" rel="nofollow"><span data-facet="Control (53)" class="search_facet_name">Control<span class=facet_count> (53)</span></span></a></li><li><input type="checkbox" name="fc_applications" class="facet_input"><a href="/product-type/isotype-controls?applications=CyTOF-ready" rel="nofollow"><span data-facet="CyTOF-ready (1)" class="search_facet_name">CyTOF-ready<span class=facet_count> (1)</span></span></a></li><li><input type="checkbox" name="fc_applications" class="facet_input"><a href="/product-type/isotype-controls?applications=Dot%20Blot" rel="nofollow"><span data-facet="Dot Blot (3)" class="search_facet_name">Dot Blot<span class=facet_count> (3)</span></span></a></li><li><input type="checkbox" name="fc_applications" class="facet_input"><a href="/product-type/isotype-controls?applications=ELISA" rel="nofollow"><span data-facet="ELISA (79)" class="search_facet_name">ELISA<span class=facet_count> (79)</span></span></a></li></ul><ul class="more_facets"><li><input type="checkbox" name="fc_applications" class="facet_input"><a href="/product-type/isotype-controls?applications=Flow%20Cytometry" rel="nofollow"><span data-facet="Flow Cytometry (73)" class="search_facet_name">Flow Cytometry<span class=facet_count> (73)</span></span></a></li><li><input type="checkbox" name="fc_applications" class="facet_input"><a href="/product-type/isotype-controls?applications=Functional%20Assay" rel="nofollow"><span data-facet="Functional Assay (6)" class="search_facet_name">Functional Assay<span class=facet_count> (6)</span></span></a></li><li><input type="checkbox" name="fc_applications" class="facet_input"><a href="/product-type/isotype-controls?applications=Immunocytochemistry/%20Immunofluorescence" rel="nofollow"><span data-facet="Immunocytochemistry/ Immunofluorescence (57)" class="search_facet_name">Immunocytochemistry / Immunofluorescence<span class=facet_count> (57)</span></span></a></li><li><input type="checkbox" name="fc_applications" class="facet_input"><a href="/product-type/isotype-controls?applications=Immunohistochemistry" rel="nofollow"><span data-facet="Immunohistochemistry (63)" class="search_facet_name">Immunohistochemistry<span class=facet_count> (63)</span></span></a></li><li><input type="checkbox" name="fc_applications" class="facet_input"><a href="/product-type/isotype-controls?applications=Immunoprecipitation" rel="nofollow"><span data-facet="Immunoprecipitation (11)" class="search_facet_name">Immunoprecipitation<span class=facet_count> (11)</span></span></a></li><li><input type="checkbox" name="fc_applications" class="facet_input"><a href="/product-type/isotype-controls?applications=SDS-PAGE" rel="nofollow"><span data-facet="SDS-PAGE (44)" class="search_facet_name">SDS-PAGE<span class=facet_count> (44)</span></span></a></li><li><input type="checkbox" name="fc_applications" class="facet_input"><a href="/product-type/isotype-controls?applications=Western%20Blot" rel="nofollow"><span data-facet="Western Blot (67)" class="search_facet_name">Western Blot<span class=facet_count> (67)</span></span></a></li> </ul> </div> </div> </div><a href="/product-type/isotype-controls?" class="search_clear_link">clear</a><div class="facet_container_reactivity"><h4><span class="facet_logo facet_logo_open"></span> <span class="facet_name">Reactivity</span></h4> <div class="facet_list"><input type="text" class="facet_category_search" value="Search"> <div class="search_icon"></div><div class="search_top_category_facets search_category_facets"><ul><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/product-type/isotype-controls?species=Mouse" rel="nofollow"><span data-facet="Mouse (51)" class="search_facet_name">Mouse<span class=facet_count> (51)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/product-type/isotype-controls?species=Rat" rel="nofollow"><span data-facet="Rat (33)" class="search_facet_name">Rat<span class=facet_count> (33)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/product-type/isotype-controls?species=Human" rel="nofollow"><span data-facet="Human (30)" class="search_facet_name">Human<span class=facet_count> (30)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/product-type/isotype-controls?species=Rabbit" rel="nofollow"><span data-facet="Rabbit (10)" class="search_facet_name">Rabbit<span class=facet_count> (10)</span></span></a></li><li class="a-z">-------------- All A - Z ---------------</li></ul></div> <div class="search_all_category_facets search_category_facets"> <ul><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/product-type/isotype-controls?species=Armenian%20Hamster" rel="nofollow"><span data-facet="Armenian Hamster (2)" class="search_facet_name">Armenian Hamster<span class=facet_count> (2)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/product-type/isotype-controls?species=Bovine" rel="nofollow"><span data-facet="Bovine (3)" class="search_facet_name">Bovine<span class=facet_count> (3)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/product-type/isotype-controls?species=Canine" rel="nofollow"><span data-facet="Canine (2)" class="search_facet_name">Canine<span class=facet_count> (2)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/product-type/isotype-controls?species=Chicken" rel="nofollow"><span data-facet="Chicken (4)" class="search_facet_name">Chicken<span class=facet_count> (4)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/product-type/isotype-controls?species=Donkey" rel="nofollow"><span data-facet="Donkey (3)" class="search_facet_name">Donkey<span class=facet_count> (3)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/product-type/isotype-controls?species=Equine" rel="nofollow"><span data-facet="Equine (4)" class="search_facet_name">Equine<span class=facet_count> (4)</span></span></a></li></ul><ul class="more_facets"><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/product-type/isotype-controls?species=Feline" rel="nofollow"><span data-facet="Feline (1)" class="search_facet_name">Feline<span class=facet_count> (1)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/product-type/isotype-controls?species=Goat" rel="nofollow"><span data-facet="Goat (4)" class="search_facet_name">Goat<span class=facet_count> (4)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/product-type/isotype-controls?species=Golden%20Syrian%20Hamster" rel="nofollow"><span data-facet="Golden Syrian Hamster (1)" class="search_facet_name">Golden Syrian Hamster<span class=facet_count> (1)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/product-type/isotype-controls?species=Guinea%20Pig" rel="nofollow"><span data-facet="Guinea Pig (2)" class="search_facet_name">Guinea Pig<span class=facet_count> (2)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/product-type/isotype-controls?species=Hamster" rel="nofollow"><span data-facet="Hamster (1)" class="search_facet_name">Hamster<span class=facet_count> (1)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/product-type/isotype-controls?species=Human" rel="nofollow"><span data-facet="Human (30)" class="search_facet_name">Human<span class=facet_count> (30)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/product-type/isotype-controls?species=Llama" rel="nofollow"><span data-facet="Llama (3)" class="search_facet_name">Llama<span class=facet_count> (3)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/product-type/isotype-controls?species=Monkey" rel="nofollow"><span data-facet="Monkey (2)" class="search_facet_name">Monkey<span class=facet_count> (2)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/product-type/isotype-controls?species=Mouse" rel="nofollow"><span data-facet="Mouse (51)" class="search_facet_name">Mouse<span class=facet_count> (51)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/product-type/isotype-controls?species=Non-species%20specific" rel="nofollow"><span data-facet="Non-species specific (1)" class="search_facet_name">Non-species specific<span class=facet_count> (1)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/product-type/isotype-controls?species=Porcine" rel="nofollow"><span data-facet="Porcine (2)" class="search_facet_name">Porcine<span class=facet_count> (2)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/product-type/isotype-controls?species=Rabbit" rel="nofollow"><span data-facet="Rabbit (10)" class="search_facet_name">Rabbit<span class=facet_count> (10)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/product-type/isotype-controls?species=Rat" rel="nofollow"><span data-facet="Rat (33)" class="search_facet_name">Rat<span class=facet_count> (33)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/product-type/isotype-controls?species=Sheep" rel="nofollow"><span data-facet="Sheep (4)" class="search_facet_name">Sheep<span class=facet_count> (4)</span></span></a></li> </ul> </div> </div> </div><a href="/product-type/isotype-controls?" class="search_clear_link">clear</a><div class="facet_container_citation"><h4><span class="facet_logo facet_logo_open"></span> <span class="facet_name">Citation</span></h4> <div class="facet_list"> <div class="search_all_category_facets search_category_facets"> <ul><li><input type="radio" name="fc_count_publications" class="facet_input"><a href="/product-type/isotype-controls?count_publications=1" rel="nofollow"><span data-facet="1 or more (56)" class="search_facet_name">1 or more (56)</span></a></li><li><input type="radio" name="fc_count_publications" class="facet_input"><a href="/product-type/isotype-controls?count_publications=10" rel="nofollow"><span data-facet="10 or more (19)" class="search_facet_name">10 or more (19)</span></a></li><li><input type="radio" name="fc_count_publications" class="facet_input"><a href="/product-type/isotype-controls?count_publications=100" rel="nofollow"><span data-facet="100 or more (5)" class="search_facet_name">100 or more (5)</span></a></li> </ul> </div> </div> </div><a href="/product-type/isotype-controls?" class="search_clear_link">clear</a><div class="facet_container_reviews"><h4><span class="facet_logo facet_logo_open"></span> <span class="facet_name">Reviews</span></h4> <div class="facet_list"> <div class="search_all_category_facets search_category_facets"> <ul><li><input type="radio" name="fc_stars_novus" class="facet_input"><a href="/product-type/isotype-controls?stars_novus=5.0" rel="nofollow"><span data-facet=" 5 (17)" class="search_facet_name"><span class="searchImage_star5"></span> 5 (17)</span></a></li><li><input type="radio" name="fc_stars_novus" class="facet_input"><a href="/product-type/isotype-controls?stars_novus=4.0" rel="nofollow"><span data-facet=" 4 & Up (19)" class="search_facet_name"><span class="searchImage_star4"></span> 4 & Up (19)</span></a></li> </ul> </div> </div> </div><a href="/product-type/isotype-controls?" class="search_clear_link">clear</a><div class="facet_container_host"><h4><span class="facet_logo facet_logo_closed"></span> <span class="facet_name">Host</span></h4> <div class="facet_list compacted"><input type="text" class="facet_category_search" value="Search"> <div class="search_icon"></div><div class="search_top_category_facets search_category_facets"><ul><li><input type="radio" name="fc_host" class="facet_input"><a href="/product-type/isotype-controls?host=Mouse" rel="nofollow"><span data-facet="Mouse (54)" class="search_facet_name">Mouse<span class=facet_count> (54)</span></span></a></li><li><input type="radio" name="fc_host" class="facet_input"><a href="/product-type/isotype-controls?host=Rat" rel="nofollow"><span data-facet="Rat (33)" class="search_facet_name">Rat<span class=facet_count> (33)</span></span></a></li><li><input type="radio" name="fc_host" class="facet_input"><a href="/product-type/isotype-controls?host=Human" rel="nofollow"><span data-facet="Human (30)" class="search_facet_name">Human<span class=facet_count> (30)</span></span></a></li><li><input type="radio" name="fc_host" class="facet_input"><a href="/product-type/isotype-controls?host=Rabbit" rel="nofollow"><span data-facet="Rabbit (10)" class="search_facet_name">Rabbit<span class=facet_count> (10)</span></span></a></li><li class="a-z">-------------- All A - Z ---------------</li></ul></div> <div class="search_all_category_facets search_category_facets"> <ul><li><input type="radio" name="fc_host" class="facet_input"><a href="/product-type/isotype-controls?host=Armenian%20Hamster" rel="nofollow"><span data-facet="Armenian Hamster (2)" class="search_facet_name">Armenian Hamster<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_host" class="facet_input"><a href="/product-type/isotype-controls?host=Bovine" rel="nofollow"><span data-facet="Bovine (3)" class="search_facet_name">Bovine<span class=facet_count> (3)</span></span></a></li><li><input type="radio" name="fc_host" class="facet_input"><a href="/product-type/isotype-controls?host=Canine" rel="nofollow"><span data-facet="Canine (2)" class="search_facet_name">Canine<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_host" class="facet_input"><a href="/product-type/isotype-controls?host=Chicken" rel="nofollow"><span data-facet="Chicken (4)" class="search_facet_name">Chicken<span class=facet_count> (4)</span></span></a></li><li><input type="radio" name="fc_host" class="facet_input"><a href="/product-type/isotype-controls?host=Donkey" rel="nofollow"><span data-facet="Donkey (3)" class="search_facet_name">Donkey<span class=facet_count> (3)</span></span></a></li><li><input type="radio" name="fc_host" class="facet_input"><a href="/product-type/isotype-controls?host=Feline" rel="nofollow"><span data-facet="Feline (1)" class="search_facet_name">Feline<span class=facet_count> (1)</span></span></a></li></ul><ul class="more_facets"><li><input type="radio" name="fc_host" class="facet_input"><a href="/product-type/isotype-controls?host=Goat" rel="nofollow"><span data-facet="Goat (4)" class="search_facet_name">Goat<span class=facet_count> (4)</span></span></a></li><li><input type="radio" name="fc_host" class="facet_input"><a href="/product-type/isotype-controls?host=Golden%20Syrian%20Hamster" rel="nofollow"><span data-facet="Golden Syrian Hamster (1)" class="search_facet_name">Golden Syrian Hamster<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_host" class="facet_input"><a href="/product-type/isotype-controls?host=Guinea%20Pig" rel="nofollow"><span data-facet="Guinea Pig (2)" class="search_facet_name">Guinea Pig<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_host" class="facet_input"><a href="/product-type/isotype-controls?host=Hamster" rel="nofollow"><span data-facet="Hamster (1)" class="search_facet_name">Hamster<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_host" class="facet_input"><a href="/product-type/isotype-controls?host=Horse" rel="nofollow"><span data-facet="Horse (4)" class="search_facet_name">Horse<span class=facet_count> (4)</span></span></a></li><li><input type="radio" name="fc_host" class="facet_input"><a href="/product-type/isotype-controls?host=Human" rel="nofollow"><span data-facet="Human (30)" class="search_facet_name">Human<span class=facet_count> (30)</span></span></a></li><li><input type="radio" name="fc_host" class="facet_input"><a href="/product-type/isotype-controls?host=Llama" rel="nofollow"><span data-facet="Llama (3)" class="search_facet_name">Llama<span class=facet_count> (3)</span></span></a></li><li><input type="radio" name="fc_host" class="facet_input"><a href="/product-type/isotype-controls?host=Monkey" rel="nofollow"><span data-facet="Monkey (2)" class="search_facet_name">Monkey<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_host" class="facet_input"><a href="/product-type/isotype-controls?host=Mouse" rel="nofollow"><span data-facet="Mouse (54)" class="search_facet_name">Mouse<span class=facet_count> (54)</span></span></a></li><li><input type="radio" name="fc_host" class="facet_input"><a href="/product-type/isotype-controls?host=Pig" rel="nofollow"><span data-facet="Pig (2)" class="search_facet_name">Pig<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_host" class="facet_input"><a href="/product-type/isotype-controls?host=Rabbit" rel="nofollow"><span data-facet="Rabbit (10)" class="search_facet_name">Rabbit<span class=facet_count> (10)</span></span></a></li><li><input type="radio" name="fc_host" class="facet_input"><a href="/product-type/isotype-controls?host=Rat" rel="nofollow"><span data-facet="Rat (33)" class="search_facet_name">Rat<span class=facet_count> (33)</span></span></a></li><li><input type="radio" name="fc_host" class="facet_input"><a href="/product-type/isotype-controls?host=Sheep" rel="nofollow"><span data-facet="Sheep (4)" class="search_facet_name">Sheep<span class=facet_count> (4)</span></span></a></li> </ul> </div> </div> </div><a href="/product-type/isotype-controls?" class="search_clear_link">clear</a><div class="facet_container_available-conjugates"><h4><span class="facet_logo facet_logo_closed"></span> <span class="facet_name">Available Conjugates</span></h4> <div class="facet_list compacted"><input type="text" class="facet_category_search" value="Search"> <div class="search_icon"></div><div class="search_top_category_facets search_category_facets"><ul><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=Unconjugated" rel="nofollow"><span data-facet="Unconjugated (157)" class="search_facet_name">Unconjugated<span class=facet_count> (157)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=Biotin" rel="nofollow"><span data-facet="Biotin (63)" class="search_facet_name">Biotin<span class=facet_count> (63)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=Alexa%20Fluor%20647" rel="nofollow"><span data-facet="Alexa Fluor 647 (58)" class="search_facet_name">Alexa Fluor 647<span class=facet_count> (58)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=FITC" rel="nofollow"><span data-facet="FITC (56)" class="search_facet_name">FITC<span class=facet_count> (56)</span></span></a></li><li class="a-z">-------------- All A - Z ---------------</li></ul></div> <div class="search_all_category_facets search_category_facets"> <ul><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=Agarose" rel="nofollow"><span data-facet="Agarose (10)" class="search_facet_name">Agarose<span class=facet_count> (10)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=Alexa%20Fluor%20350" rel="nofollow"><span data-facet="Alexa Fluor 350 (17)" class="search_facet_name">Alexa Fluor 350<span class=facet_count> (17)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=Alexa%20Fluor%20405" rel="nofollow"><span data-facet="Alexa Fluor 405 (29)" class="search_facet_name">Alexa Fluor 405<span class=facet_count> (29)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=Alexa%20Fluor%20488" rel="nofollow"><span data-facet="Alexa Fluor 488 (54)" class="search_facet_name">Alexa Fluor 488<span class=facet_count> (54)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=Alexa%20Fluor%20532" rel="nofollow"><span data-facet="Alexa Fluor 532 (16)" class="search_facet_name">Alexa Fluor 532<span class=facet_count> (16)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=Alexa%20Fluor%20546" rel="nofollow"><span data-facet="Alexa Fluor 546 (20)" class="search_facet_name">Alexa Fluor 546<span class=facet_count> (20)</span></span></a></li></ul><ul class="more_facets"><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=Alexa%20Fluor%20594" rel="nofollow"><span data-facet="Alexa Fluor 594 (25)" class="search_facet_name">Alexa Fluor 594<span class=facet_count> (25)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=Alexa%20Fluor%20647" rel="nofollow"><span data-facet="Alexa Fluor 647 (58)" class="search_facet_name">Alexa Fluor 647<span class=facet_count> (58)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=Alexa%20Fluor%20700" rel="nofollow"><span data-facet="Alexa Fluor 700 (31)" class="search_facet_name">Alexa Fluor 700<span class=facet_count> (31)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=Alexa%20Fluor%20750" rel="nofollow"><span data-facet="Alexa Fluor 750 (24)" class="search_facet_name">Alexa Fluor 750<span class=facet_count> (24)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=Alkaline%20Phosphatase" rel="nofollow"><span data-facet="Alkaline Phosphatase (11)" class="search_facet_name">Alkaline Phosphatase<span class=facet_count> (11)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=Allophycocyanin" rel="nofollow"><span data-facet="Allophycocyanin (39)" class="search_facet_name">Allophycocyanin<span class=facet_count> (39)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=Allophycocyanin/Cy7" rel="nofollow"><span data-facet="Allophycocyanin/Cy7 (15)" class="search_facet_name">Allophycocyanin / Cy7<span class=facet_count> (15)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=Biotin" rel="nofollow"><span data-facet="Biotin (63)" class="search_facet_name">Biotin<span class=facet_count> (63)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=DyLight%20350" rel="nofollow"><span data-facet="DyLight 350 (25)" class="search_facet_name">DyLight 350<span class=facet_count> (25)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=DyLight%20405" rel="nofollow"><span data-facet="DyLight 405 (25)" class="search_facet_name">DyLight 405<span class=facet_count> (25)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=DyLight%20488" rel="nofollow"><span data-facet="DyLight 488 (25)" class="search_facet_name">DyLight 488<span class=facet_count> (25)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=DyLight%20550" rel="nofollow"><span data-facet="DyLight 550 (22)" class="search_facet_name">DyLight 550<span class=facet_count> (22)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=DyLight%20594" rel="nofollow"><span data-facet="DyLight 594 (19)" class="search_facet_name">DyLight 594<span class=facet_count> (19)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=DyLight%20650" rel="nofollow"><span data-facet="DyLight 650 (23)" class="search_facet_name">DyLight 650<span class=facet_count> (23)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=DyLight%20680" rel="nofollow"><span data-facet="DyLight 680 (25)" class="search_facet_name">DyLight 680<span class=facet_count> (25)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=DyLight%20755" rel="nofollow"><span data-facet="DyLight 755 (25)" class="search_facet_name">DyLight 755<span class=facet_count> (25)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=FITC" rel="nofollow"><span data-facet="FITC (56)" class="search_facet_name">FITC<span class=facet_count> (56)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=Fluorescein" rel="nofollow"><span data-facet="Fluorescein (11)" class="search_facet_name">Fluorescein<span class=facet_count> (11)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=HRP" rel="nofollow"><span data-facet="HRP (52)" class="search_facet_name">HRP<span class=facet_count> (52)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=Janelia%20Fluor%20549" rel="nofollow"><span data-facet="Janelia Fluor 549 (18)" class="search_facet_name">Janelia Fluor 549<span class=facet_count> (18)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=Janelia%20Fluor%20646" rel="nofollow"><span data-facet="Janelia Fluor 646 (17)" class="search_facet_name">Janelia Fluor 646<span class=facet_count> (17)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=PE" rel="nofollow"><span data-facet="PE (27)" class="search_facet_name">PE<span class=facet_count> (27)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=PE/Atto594" rel="nofollow"><span data-facet="PE/Atto594 (13)" class="search_facet_name">PE / Atto594<span class=facet_count> (13)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=PE/Cy5" rel="nofollow"><span data-facet="PE/Cy5 (6)" class="search_facet_name">PE / Cy5<span class=facet_count> (6)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=PE/Cy5.5" rel="nofollow"><span data-facet="PE/Cy5.5 (15)" class="search_facet_name">PE / Cy5.5<span class=facet_count> (15)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=PE/Cy7" rel="nofollow"><span data-facet="PE/Cy7 (18)" class="search_facet_name">PE / Cy7<span class=facet_count> (18)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=PerCP" rel="nofollow"><span data-facet="PerCP (24)" class="search_facet_name">PerCP<span class=facet_count> (24)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=PerCP%20(Peridinin-chlorophyll%20Protein%20Complex)" rel="nofollow"><span data-facet="PerCP (Peridinin-chlorophyll Protein Complex) (8)" class="search_facet_name">PerCP (Peridinin-chlorophyll Protein Complex)<span class=facet_count> (8)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=PerCP/Cy5.5" rel="nofollow"><span data-facet="PerCP/Cy5.5 (6)" class="search_facet_name">PerCP / Cy5.5<span class=facet_count> (6)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=Phycoerythrin" rel="nofollow"><span data-facet="Phycoerythrin (11)" class="search_facet_name">Phycoerythrin<span class=facet_count> (11)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=Rhodamine" rel="nofollow"><span data-facet="Rhodamine (20)" class="search_facet_name">Rhodamine<span class=facet_count> (20)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=Texas%20Red" rel="nofollow"><span data-facet="Texas Red (19)" class="search_facet_name">Texas Red<span class=facet_count> (19)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=Unconjugated" rel="nofollow"><span data-facet="Unconjugated (157)" class="search_facet_name">Unconjugated<span class=facet_count> (157)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=mFluor%20Violet%20450%20SE" rel="nofollow"><span data-facet="mFluor Violet 450 SE (1)" class="search_facet_name">mFluor Violet 450 SE<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=mFluor%20Violet%20500%20SE" rel="nofollow"><span data-facet="mFluor Violet 500 SE (1)" class="search_facet_name">mFluor Violet 500 SE<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/product-type/isotype-controls?facet_conjugate=mFluor%20Violet%20610%20SE" rel="nofollow"><span data-facet="mFluor Violet 610 SE (1)" class="search_facet_name">mFluor Violet 610 SE<span class=facet_count> (1)</span></span></a></li> </ul> </div> </div> </div><a href="/product-type/isotype-controls?" class="search_clear_link">clear</a><div class="facet_container_format"><h4><span class="facet_logo facet_logo_closed"></span> <span class="facet_name">Format</span></h4> <div class="facet_list compacted"> <div class="search_all_category_facets search_category_facets"> <ul><li><input type="radio" name="fc_facet_format" class="facet_input"><a href="/product-type/isotype-controls?facet_format=Purified" rel="nofollow"><span data-facet="Purified (58)" class="search_facet_name">Purified<span class=facet_count> (58)</span></span></a></li><li><input type="radio" name="fc_facet_format" class="facet_input"><a href="/product-type/isotype-controls?facet_format=Azide%20and%20BSA%20Free" rel="nofollow"><span data-facet="Azide and BSA Free (13)" class="search_facet_name">Azide and BSA Free<span class=facet_count> (13)</span></span></a></li><li><input type="radio" name="fc_facet_format" class="facet_input"><a href="/product-type/isotype-controls?facet_format=Azide%20Free" rel="nofollow"><span data-facet="Azide Free (4)" class="search_facet_name">Azide Free<span class=facet_count> (4)</span></span></a></li><li><input type="radio" name="fc_facet_format" class="facet_input"><a href="/product-type/isotype-controls?facet_format=Low%20Endotoxin%20and%20Azide%20Free" rel="nofollow"><span data-facet="Low Endotoxin and Azide Free (2)" class="search_facet_name">Low Endotoxin and Azide Free<span class=facet_count> (2)</span></span></a></li> </ul> </div> </div> </div><a href="/product-type/isotype-controls?" class="search_clear_link">clear</a><div class="facet_container_modification"><h4><span class="facet_logo facet_logo_closed"></span> <span class="facet_name">Modification</span></h4> <div class="facet_list compacted"> <div class="search_all_category_facets search_category_facets"> <ul><li><input type="radio" name="fc_modification" class="facet_input"><a href="/product-type/isotype-controls?modification=No%20Modification" rel="nofollow"><span data-facet="No Modification (165)" class="search_facet_name">No Modification <span class=facet_count> (165)</span></span></a></li> </ul> </div> </div> </div><a href="/product-type/isotype-controls?" class="search_clear_link">clear</a><div class="facet_container_clonality"><h4><span class="facet_logo facet_logo_closed"></span> <span class="facet_name">Clonality</span></h4> <div class="facet_list compacted"> <div class="search_all_category_facets search_category_facets"> <ul><li><input type="radio" name="fc_clonality" class="facet_input"><a href="/product-type/isotype-controls?clonality=Monoclonal" rel="nofollow"><span data-facet="Monoclonal (63)" class="search_facet_name">Monoclonal<span class=facet_count> (63)</span></span></a></li><li><input type="radio" name="fc_clonality" class="facet_input"><a href="/product-type/isotype-controls?clonality=Polyclonal" rel="nofollow"><span data-facet="Polyclonal (54)" class="search_facet_name">Polyclonal<span class=facet_count> (54)</span></span></a></li> </ul> </div> </div> </div><a href="/product-type/isotype-controls?" class="search_clear_link">clear</a><div class="facet_container_clone"><h4><span class="facet_logo facet_logo_closed"></span> <span class="facet_name">Clone</span></h4> <div class="facet_list compacted"><input type="text" class="facet_category_search" value="Search"> <div class="search_icon"></div><div class="search_top_category_facets search_category_facets"><ul><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=60024B" rel="nofollow"><span data-facet="60024B (2)" class="search_facet_name">60024B<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=MAB1641" rel="nofollow"><span data-facet="MAB1641 (2)" class="search_facet_name">MAB1641<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=P3.6.2.8.1" rel="nofollow"><span data-facet="P3.6.2.8.1 (2)" class="search_facet_name">P3.6.2.8.1<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=R2a" rel="nofollow"><span data-facet="R2a (2)" class="search_facet_name">R2a<span class=facet_count> (2)</span></span></a></li><li class="a-z">-------------- All A - Z ---------------</li></ul></div> <div class="search_all_category_facets search_category_facets"> <ul><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=11711" rel="nofollow"><span data-facet="11711 (1)" class="search_facet_name">11711<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=11711R" rel="nofollow"><span data-facet="11711R (1)" class="search_facet_name">11711R<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=20102" rel="nofollow"><span data-facet="20102 (1)" class="search_facet_name">20102<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=133303" rel="nofollow"><span data-facet="133303 (1)" class="search_facet_name">133303<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=133304" rel="nofollow"><span data-facet="133304 (1)" class="search_facet_name">133304<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=133316" rel="nofollow"><span data-facet="133316 (1)" class="search_facet_name">133316<span class=facet_count> (1)</span></span></a></li></ul><ul class="more_facets"><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=141945" rel="nofollow"><span data-facet="141945 (1)" class="search_facet_name">141945<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=141945R" rel="nofollow"><span data-facet="141945R (1)" class="search_facet_name">141945R<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=149/10H5" rel="nofollow"><span data-facet="149/10H5 (1)" class="search_facet_name">149 / 10H5<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=20102R" rel="nofollow"><span data-facet="20102R (1)" class="search_facet_name">20102R<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=20116" rel="nofollow"><span data-facet="20116 (1)" class="search_facet_name">20116<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=299Arm" rel="nofollow"><span data-facet="299Arm (1)" class="search_facet_name">299Arm<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=2A3" rel="nofollow"><span data-facet="2A3 (1)" class="search_facet_name">2A3<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=43414" rel="nofollow"><span data-facet="43414 (1)" class="search_facet_name">43414<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=43414R" rel="nofollow"><span data-facet="43414R (1)" class="search_facet_name">43414R<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=54447" rel="nofollow"><span data-facet="54447 (1)" class="search_facet_name">54447<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=54447R" rel="nofollow"><span data-facet="54447R (1)" class="search_facet_name">54447R<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=60024B" rel="nofollow"><span data-facet="60024B (2)" class="search_facet_name">60024B<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=73009" rel="nofollow"><span data-facet="73009 (1)" class="search_facet_name">73009<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=B-D38" rel="nofollow"><span data-facet="B-D38 (1)" class="search_facet_name">B-D38<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=B-F33" rel="nofollow"><span data-facet="B-F33 (1)" class="search_facet_name">B-F33<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=C1.18.4" rel="nofollow"><span data-facet="C1.18.4 (1)" class="search_facet_name">C1.18.4<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=C184" rel="nofollow"><span data-facet="C184 (1)" class="search_facet_name">C184<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=F8" rel="nofollow"><span data-facet="F8 (1)" class="search_facet_name">F8<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=HPN33" rel="nofollow"><span data-facet="HPN33 (1)" class="search_facet_name">HPN33<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=IGG2a/6723" rel="nofollow"><span data-facet="IGG2a/6723 (1)" class="search_facet_name">IGG2a / 6723<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=KLH/G1-2-2" rel="nofollow"><span data-facet="KLH/G1-2-2 (1)" class="search_facet_name">KLH / G1-2-2<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=KLH/G2a-1-1" rel="nofollow"><span data-facet="KLH/G2a-1-1 (1)" class="search_facet_name">KLH / G2a-1-1<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=LF2" rel="nofollow"><span data-facet="LF2 (1)" class="search_facet_name">LF2<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=M2A" rel="nofollow"><span data-facet="M2A (1)" class="search_facet_name">M2A<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=M2AK" rel="nofollow"><span data-facet="M2AK (1)" class="search_facet_name">M2AK<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=M2AL" rel="nofollow"><span data-facet="M2AL (1)" class="search_facet_name">M2AL<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=M2B" rel="nofollow"><span data-facet="M2B (1)" class="search_facet_name">M2B<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=M2BK" rel="nofollow"><span data-facet="M2BK (1)" class="search_facet_name">M2BK<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=M2BL" rel="nofollow"><span data-facet="M2BL (1)" class="search_facet_name">M2BL<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=MAB1641" rel="nofollow"><span data-facet="MAB1641 (2)" class="search_facet_name">MAB1641<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=MAK" rel="nofollow"><span data-facet="MAK (1)" class="search_facet_name">MAK<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=MG1" rel="nofollow"><span data-facet="MG1 (1)" class="search_facet_name">MG1<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=MG1K" rel="nofollow"><span data-facet="MG1K (1)" class="search_facet_name">MG1K<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=MG1L" rel="nofollow"><span data-facet="MG1L (1)" class="search_facet_name">MG1L<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=MG2b" rel="nofollow"><span data-facet="MG2b (1)" class="search_facet_name">MG2b<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=MG3" rel="nofollow"><span data-facet="MG3 (1)" class="search_facet_name">MG3<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=MG3K" rel="nofollow"><span data-facet="MG3K (1)" class="search_facet_name">MG3K<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=MG3L" rel="nofollow"><span data-facet="MG3L (1)" class="search_facet_name">MG3L<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=MMK" rel="nofollow"><span data-facet="MMK (1)" class="search_facet_name">MMK<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=MML" rel="nofollow"><span data-facet="MML (1)" class="search_facet_name">MML<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=MOPC-21" rel="nofollow"><span data-facet="MOPC-21 (1)" class="search_facet_name">MOPC-21<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=MP21" rel="nofollow"><span data-facet="MP21 (1)" class="search_facet_name">MP21<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=MPC-11" rel="nofollow"><span data-facet="MPC-11 (1)" class="search_facet_name">MPC-11<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=NIP/M-2" rel="nofollow"><span data-facet="NIP/M-2 (1)" class="search_facet_name">NIP / M-2<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=P3.6.2.8.1" rel="nofollow"><span data-facet="P3.6.2.8.1 (2)" class="search_facet_name">P3.6.2.8.1<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=PC11" rel="nofollow"><span data-facet="PC11 (1)" class="search_facet_name">PC11<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=PFR-03" rel="nofollow"><span data-facet="PFR-03 (1)" class="search_facet_name">PFR-03<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=PLRV219" rel="nofollow"><span data-facet="PLRV219 (1)" class="search_facet_name">PLRV219<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=R2a" rel="nofollow"><span data-facet="R2a (2)" class="search_facet_name">R2a<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=RG1" rel="nofollow"><span data-facet="RG1 (1)" class="search_facet_name">RG1<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=RG1L" rel="nofollow"><span data-facet="RG1L (1)" class="search_facet_name">RG1L<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=RG2aL" rel="nofollow"><span data-facet="RG2aL (1)" class="search_facet_name">RG2aL<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=RG2cK" rel="nofollow"><span data-facet="RG2cK (1)" class="search_facet_name">RG2cK<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/product-type/isotype-controls?clone=eBRM" rel="nofollow"><span data-facet="eBRM (1)" class="search_facet_name">eBRM<span class=facet_count> (1)</span></span></a></li> </ul> </div> </div> </div><a href="/product-type/isotype-controls?" class="search_clear_link">clear</a><div class="facet_container_gene-symbol"><h4><span class="facet_logo facet_logo_closed"></span> <span class="facet_name">Gene Symbol</span></h4> <div class="facet_list compacted"> <div class="search_all_category_facets search_category_facets"> <ul><li><input type="radio" name="fc_gene_symbol" class="facet_input"><a href="/product-type/isotype-controls?gene_symbol=IGHG1" rel="nofollow"><span data-facet="IGHG1 (36)" class="search_facet_name">IGHG1<span class=facet_count> (36)</span></span></a></li><li><input type="radio" name="fc_gene_symbol" class="facet_input"><a href="/product-type/isotype-controls?gene_symbol=IGHM" rel="nofollow"><span data-facet="IGHM (26)" class="search_facet_name">IGHM<span class=facet_count> (26)</span></span></a></li><li><input type="radio" name="fc_gene_symbol" class="facet_input"><a href="/product-type/isotype-controls?gene_symbol=IGHG3" rel="nofollow"><span data-facet="IGHG3 (7)" class="search_facet_name">IGHG3<span class=facet_count> (7)</span></span></a></li><li><input type="radio" name="fc_gene_symbol" class="facet_input"><a href="/product-type/isotype-controls?gene_symbol=IGHG2" rel="nofollow"><span data-facet="IGHG2 (3)" class="search_facet_name">IGHG2<span class=facet_count> (3)</span></span></a></li><li><input type="radio" name="fc_gene_symbol" class="facet_input"><a href="/product-type/isotype-controls?gene_symbol=IGHA1" rel="nofollow"><span data-facet="IGHA1 (2)" class="search_facet_name">IGHA1<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_gene_symbol" class="facet_input"><a href="/product-type/isotype-controls?gene_symbol=IGHE" rel="nofollow"><span data-facet="IGHE (1)" class="search_facet_name">IGHE<span class=facet_count> (1)</span></span></a></li> </ul> </div> </div> </div><a href="/product-type/isotype-controls?" class="search_clear_link">clear</a><div class="facet_container_images-type"><h4><span class="facet_logo facet_logo_closed"></span> <span class="facet_name">Images Type</span></h4> <div class="facet_list compacted"><input type="text" class="facet_category_search" value="Search"> <div class="search_icon"></div><div class="search_top_category_facets search_category_facets"><ul><li><input type="radio" name="fc_images_type" class="facet_input"><a href="/product-type/isotype-controls?images_type=SDS-PAGE" rel="nofollow"><span data-facet="SDS-PAGE (42)" class="search_facet_name">SDS-PAGE<span class=facet_count> (42)</span></span></a></li><li><input type="radio" name="fc_images_type" class="facet_input"><a href="/product-type/isotype-controls?images_type=Flow%20Cytometry" rel="nofollow"><span data-facet="Flow Cytometry (15)" class="search_facet_name">Flow Cytometry<span class=facet_count> (15)</span></span></a></li><li><input type="radio" name="fc_images_type" class="facet_input"><a href="/product-type/isotype-controls?images_type=Control" rel="nofollow"><span data-facet="Control (14)" class="search_facet_name">Control<span class=facet_count> (14)</span></span></a></li><li><input type="radio" name="fc_images_type" class="facet_input"><a href="/product-type/isotype-controls?images_type=Western%20Blot" rel="nofollow"><span data-facet="Western Blot (13)" class="search_facet_name">Western Blot<span class=facet_count> (13)</span></span></a></li><li class="a-z">-------------- All A - Z ---------------</li></ul></div> <div class="search_all_category_facets search_category_facets"> <ul><li><input type="radio" name="fc_images_type" class="facet_input"><a href="/product-type/isotype-controls?images_type=Control" rel="nofollow"><span data-facet="Control (14)" class="search_facet_name">Control<span class=facet_count> (14)</span></span></a></li><li><input type="radio" name="fc_images_type" class="facet_input"><a href="/product-type/isotype-controls?images_type=Dot%20Blot" rel="nofollow"><span data-facet="Dot Blot (3)" class="search_facet_name">Dot Blot<span class=facet_count> (3)</span></span></a></li><li><input type="radio" name="fc_images_type" class="facet_input"><a href="/product-type/isotype-controls?images_type=ELISA" rel="nofollow"><span data-facet="ELISA (8)" class="search_facet_name">ELISA<span class=facet_count> (8)</span></span></a></li><li><input type="radio" name="fc_images_type" class="facet_input"><a href="/product-type/isotype-controls?images_type=Flow%20(Cell%20Surface)" rel="nofollow"><span data-facet="Flow (Cell Surface) (1)" class="search_facet_name">Flow (Cell Surface)<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_images_type" class="facet_input"><a href="/product-type/isotype-controls?images_type=Flow%20(Intracellular)" rel="nofollow"><span data-facet="Flow (Intracellular) (1)" class="search_facet_name">Flow (Intracellular)<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_images_type" class="facet_input"><a href="/product-type/isotype-controls?images_type=Flow%20Cytometry" rel="nofollow"><span data-facet="Flow Cytometry (15)" class="search_facet_name">Flow Cytometry<span class=facet_count> (15)</span></span></a></li></ul><ul class="more_facets"><li><input type="radio" name="fc_images_type" class="facet_input"><a href="/product-type/isotype-controls?images_type=Functional" rel="nofollow"><span data-facet="Functional (1)" class="search_facet_name">Functional<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_images_type" class="facet_input"><a href="/product-type/isotype-controls?images_type=Immunocytochemistry/%20Immunofluorescence" rel="nofollow"><span data-facet="Immunocytochemistry/ Immunofluorescence (3)" class="search_facet_name">Immunocytochemistry / Immunofluorescence<span class=facet_count> (3)</span></span></a></li><li><input type="radio" name="fc_images_type" class="facet_input"><a href="/product-type/isotype-controls?images_type=Immunofluorescence" rel="nofollow"><span data-facet="Immunofluorescence (1)" class="search_facet_name">Immunofluorescence<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_images_type" class="facet_input"><a href="/product-type/isotype-controls?images_type=Immunohistochemistry" rel="nofollow"><span data-facet="Immunohistochemistry (4)" class="search_facet_name">Immunohistochemistry<span class=facet_count> (4)</span></span></a></li><li><input type="radio" name="fc_images_type" class="facet_input"><a href="/product-type/isotype-controls?images_type=Immunohistochemistry-Frozen" rel="nofollow"><span data-facet="Immunohistochemistry-Frozen (1)" class="search_facet_name">Immunohistochemistry-Frozen<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_images_type" class="facet_input"><a href="/product-type/isotype-controls?images_type=Immunohistochemistry-Paraffin" rel="nofollow"><span data-facet="Immunohistochemistry-Paraffin (2)" class="search_facet_name">Immunohistochemistry-Paraffin<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_images_type" class="facet_input"><a href="/product-type/isotype-controls?images_type=Immunoprecipitation" rel="nofollow"><span data-facet="Immunoprecipitation (1)" class="search_facet_name">Immunoprecipitation<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_images_type" class="facet_input"><a href="/product-type/isotype-controls?images_type=SDS-PAGE" rel="nofollow"><span data-facet="SDS-PAGE (42)" class="search_facet_name">SDS-PAGE<span class=facet_count> (42)</span></span></a></li><li><input type="radio" name="fc_images_type" class="facet_input"><a href="/product-type/isotype-controls?images_type=Western%20Blot" rel="nofollow"><span data-facet="Western Blot (13)" class="search_facet_name">Western Blot<span class=facet_count> (13)</span></span></a></li> </ul> </div> </div> </div><a href="/product-type/isotype-controls?" class="search_clear_link">clear</a><div class="facet_container_isotype"><h4><span class="facet_logo facet_logo_closed"></span> <span class="facet_name">Isotype</span></h4> <div class="facet_list compacted"><input type="text" class="facet_category_search" value="Search"> <div class="search_icon"></div><div class="search_top_category_facets search_category_facets"><ul><li><input type="radio" name="fc_isotype" class="facet_input"><a href="/product-type/isotype-controls?isotype=IgG" rel="nofollow"><span data-facet="IgG (55)" class="search_facet_name">IgG<span class=facet_count> (55)</span></span></a></li><li><input type="radio" name="fc_isotype" class="facet_input"><a href="/product-type/isotype-controls?isotype=IgM" rel="nofollow"><span data-facet="IgM (24)" class="search_facet_name">IgM<span class=facet_count> (24)</span></span></a></li><li><input type="radio" name="fc_isotype" class="facet_input"><a href="/product-type/isotype-controls?isotype=IgG2b" rel="nofollow"><span data-facet="IgG2b (14)" class="search_facet_name">IgG2b<span class=facet_count> (14)</span></span></a></li><li><input type="radio" name="fc_isotype" class="facet_input"><a href="/product-type/isotype-controls?isotype=IgG2a" rel="nofollow"><span data-facet="IgG2a (12)" class="search_facet_name">IgG2a<span class=facet_count> (12)</span></span></a></li><li class="a-z">-------------- All A - Z ---------------</li></ul></div> <div class="search_all_category_facets search_category_facets"> <ul><li><input type="radio" name="fc_isotype" class="facet_input"><a href="/product-type/isotype-controls?isotype=IgA" rel="nofollow"><span data-facet="IgA (3)" class="search_facet_name">IgA<span class=facet_count> (3)</span></span></a></li><li><input type="radio" name="fc_isotype" class="facet_input"><a href="/product-type/isotype-controls?isotype=IgA%20Kappa" rel="nofollow"><span data-facet="IgA Kappa (2)" class="search_facet_name">IgA Kappa<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_isotype" class="facet_input"><a href="/product-type/isotype-controls?isotype=IgA%20Lambda" rel="nofollow"><span data-facet="IgA Lambda (1)" class="search_facet_name">IgA Lambda<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_isotype" class="facet_input"><a href="/product-type/isotype-controls?isotype=IgE" rel="nofollow"><span data-facet="IgE (1)" class="search_facet_name">IgE<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_isotype" class="facet_input"><a href="/product-type/isotype-controls?isotype=IgG" rel="nofollow"><span data-facet="IgG (55)" class="search_facet_name">IgG<span class=facet_count> (55)</span></span></a></li><li><input type="radio" name="fc_isotype" class="facet_input"><a href="/product-type/isotype-controls?isotype=IgG1" rel="nofollow"><span data-facet="IgG1 (9)" class="search_facet_name">IgG1<span class=facet_count> (9)</span></span></a></li></ul><ul class="more_facets"><li><input type="radio" name="fc_isotype" class="facet_input"><a href="/product-type/isotype-controls?isotype=IgG1%20Kappa" rel="nofollow"><span data-facet="IgG1 Kappa (11)" class="search_facet_name">IgG1 Kappa<span class=facet_count> (11)</span></span></a></li><li><input type="radio" name="fc_isotype" class="facet_input"><a href="/product-type/isotype-controls?isotype=IgG1%20Lambda" rel="nofollow"><span data-facet="IgG1 Lambda (2)" class="search_facet_name">IgG1 Lambda<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_isotype" class="facet_input"><a href="/product-type/isotype-controls?isotype=IgG2" rel="nofollow"><span data-facet="IgG2 (3)" class="search_facet_name">IgG2<span class=facet_count> (3)</span></span></a></li><li><input type="radio" name="fc_isotype" class="facet_input"><a href="/product-type/isotype-controls?isotype=IgG2a" rel="nofollow"><span data-facet="IgG2a (12)" class="search_facet_name">IgG2a<span class=facet_count> (12)</span></span></a></li><li><input type="radio" name="fc_isotype" class="facet_input"><a href="/product-type/isotype-controls?isotype=IgG2a%20Kappa" rel="nofollow"><span data-facet="IgG2a Kappa (4)" class="search_facet_name">IgG2a Kappa<span class=facet_count> (4)</span></span></a></li><li><input type="radio" name="fc_isotype" class="facet_input"><a href="/product-type/isotype-controls?isotype=IgG2a%20Lambda" rel="nofollow"><span data-facet="IgG2a Lambda (1)" class="search_facet_name">IgG2a Lambda<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_isotype" class="facet_input"><a href="/product-type/isotype-controls?isotype=IgG2b" rel="nofollow"><span data-facet="IgG2b (14)" class="search_facet_name">IgG2b<span class=facet_count> (14)</span></span></a></li><li><input type="radio" name="fc_isotype" class="facet_input"><a href="/product-type/isotype-controls?isotype=IgG2b%20Kappa" rel="nofollow"><span data-facet="IgG2b Kappa (2)" class="search_facet_name">IgG2b Kappa<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_isotype" class="facet_input"><a href="/product-type/isotype-controls?isotype=IgG2b%20Lambda" rel="nofollow"><span data-facet="IgG2b Lambda (1)" class="search_facet_name">IgG2b Lambda<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_isotype" class="facet_input"><a href="/product-type/isotype-controls?isotype=IgG2c%20Kappa" rel="nofollow"><span data-facet="IgG2c Kappa (1)" class="search_facet_name">IgG2c Kappa<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_isotype" class="facet_input"><a href="/product-type/isotype-controls?isotype=IgG3" rel="nofollow"><span data-facet="IgG3 (7)" class="search_facet_name">IgG3<span class=facet_count> (7)</span></span></a></li><li><input type="radio" name="fc_isotype" class="facet_input"><a href="/product-type/isotype-controls?isotype=IgG3%20Kappa" rel="nofollow"><span data-facet="IgG3 Kappa (1)" class="search_facet_name">IgG3 Kappa<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_isotype" class="facet_input"><a href="/product-type/isotype-controls?isotype=IgG3%20Lambda" rel="nofollow"><span data-facet="IgG3 Lambda (2)" class="search_facet_name">IgG3 Lambda<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_isotype" class="facet_input"><a href="/product-type/isotype-controls?isotype=IgG4" rel="nofollow"><span data-facet="IgG4 (2)" class="search_facet_name">IgG4<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_isotype" class="facet_input"><a href="/product-type/isotype-controls?isotype=IgM" rel="nofollow"><span data-facet="IgM (24)" class="search_facet_name">IgM<span class=facet_count> (24)</span></span></a></li><li><input type="radio" name="fc_isotype" class="facet_input"><a href="/product-type/isotype-controls?isotype=IgM%20Kappa" rel="nofollow"><span data-facet="IgM Kappa (2)" class="search_facet_name">IgM Kappa<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_isotype" class="facet_input"><a href="/product-type/isotype-controls?isotype=IgM%20Lambda" rel="nofollow"><span data-facet="IgM Lambda (4)" class="search_facet_name">IgM Lambda<span class=facet_count> (4)</span></span></a></li><li><input type="radio" name="fc_isotype" class="facet_input"><a href="/product-type/isotype-controls?isotype=IgY" rel="nofollow"><span data-facet="IgY (1)" class="search_facet_name">IgY<span class=facet_count> (1)</span></span></a></li> </ul> </div> </div> </div><a href="/product-type/isotype-controls?" class="search_clear_link">clear</a><div class="facet_container_preservative"><h4><span class="facet_logo facet_logo_closed"></span> <span class="facet_name">Preservative</span></h4> <div class="facet_list compacted"><div class="search_top_category_facets search_category_facets"><ul><li><input type="radio" name="fc_preservative" class="facet_input"><a href="/product-type/isotype-controls?preservative=No%20Preservative" rel="nofollow"><span data-facet="No Preservative (66)" class="search_facet_name">No Preservative<span class=facet_count> (66)</span></span></a></li><li><input type="radio" name="fc_preservative" class="facet_input"><a href="/product-type/isotype-controls?preservative=0.01%%20Sodium%20Azide" rel="nofollow"><span data-facet="0.01% Sodium Azide (48)" class="search_facet_name">0.01% Sodium Azide<span class=facet_count> (48)</span></span></a></li><li><input type="radio" name="fc_preservative" class="facet_input"><a href="/product-type/isotype-controls?preservative=0.1%%20Sodium%20Azide" rel="nofollow"><span data-facet="0.1% Sodium Azide (12)" class="search_facet_name">0.1% Sodium Azide<span class=facet_count> (12)</span></span></a></li><li><input type="radio" name="fc_preservative" class="facet_input"><a 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<td>=</td> <td>Insect</td> </tr> <tr> <td>Av</td> <td>=</td> <td>Avian</td> <td>Ll</td> <td>=</td> <td>Llama</td> </tr> <tr> <td>Bb</td> <td>=</td> <td>Baboon</td> <td>Ma</td> <td>=</td> <td>Mammal</td> </tr> <tr> <td>Ba</td> <td>=</td> <td>Bacteria</td> <td>Mk</td> <td>=</td> <td>Monkey</td> </tr> <tr> <td>Bv</td> <td>=</td> <td>Bovine</td> <td>Mu</td> <td>=</td> <td>Mouse</td> </tr> <tr> <td>Ca</td> <td>=</td> <td>Canine</td> <td>Multi</td> <td>=</td> <td>Multi-species</td> </tr> <tr> <td>Ce</td> <td>=</td> <td>C. Elegans</td> <td>NA</td> <td>=</td> <td>Non-species specific</td> </tr> <tr> <td>Ch</td> <td>=</td> <td>Chicken</td> <td>Or</td> <td>=</td> <td>Orangutan</td> </tr> <tr> <td>ChHa</td> <td>=</td> <td>Chinese Hamster</td> <td>Pl</td> <td>=</td> <td>Plant</td> </tr> <tr> <td>Cm</td> <td>=</td> <td>Cynomolgus Monkey</td> <td>Pm</td> <td>=</td> <td>Primate</td> </tr> <tr> <td>Do</td> <td>=</td> <td>Donkey</td> <td>Po</td> <td>=</td> <td>Porcine</td> </tr> <tr> <td>Dr</td> <td>=</td> <td>Drosophilia</td> <td>Rb</td> <td>=</td> <td>Rabbit</td> </tr> <tr> <td>Ec</td> <td>=</td> <td>E. 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Isotype controls provide an estimate of non-specific binding of an antibody that may occur during an assay. Use the filters to easily sort our isotype control products by species, isotype reactivities, and labels.</p></div><div class="search_summary">165 Results for ""</div><div class="grpListGrid"> <div class="outdiv"><a href="/product-type/isotype-controls?showGrid=false" class="active_link" rel="nofollow"> <div class="listView"></div> List</a></div> <div class="outdiv listgriddivider"><a href="/product-type/isotype-controls?showGrid=true" class="notactive_link" rel="nofollow"> <div class="gridView"></div> Grid</a></div> </div></div><div id="equalize"><div class="new-search-result search-result-wrapper" > <div class="name"><span> <div class="catalog_number_wrapper not3column"> <a href="/products/igg-isotype-control_ab-108-c">AB-108-C</a> </div><h2 class="col3_hdr"><a data-brand="rnd" data-id="AB-108-C" data-name="Goat IgG Isotype Control [Unconjugated]" data-position="1" class="ecommerce_link" href="/products/igg-isotype-control_ab-108-c" title="Goat IgG Isotype Control [Unconjugated]" ><span> Goat IgG Isotype Control [Unconjugated]</span></a></div></h2> <div class="sub-header"> <div class="flourish_left"></div> <div class="flourish_right"></div><div class="prod_details_section"> <div class="segment"> <a title="2 Reviews for this product" href="/products/igg-isotype-control_ab-108-c#ReviewsSection"><span class="stars5"></span> (2 Reviews)</a> </div> <div class="segment"> <a title="626 Publications specific to this product" href="/products/igg-isotype-control_ab-108-c#PublicationSection"><span class="publications"></span> (626 Publications)</a> </div> <div class="segment" style="float:right;"> <strong>1 mg</strong><span class="product_price" data-sku="AB-108-C"></span> </div> </div> </div> <div class="images"> <div class="catalog_number_wrapper_col3 forcol3"> <a href="/products/igg-isotype-control_ab-108-c">AB-108-C</a> </div><div id="ss_prev0" class="cycle-pager"><div class="pager_left_on"></div></div><div class="cycle-slideshow slideshows" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-0" data-cycle-prev="#ss_prev0" data-cycle-next="#ss_next0" data-cycle-caption="#image-caption-AB-108-C" data-cycle-caption-template="Image {{slideNum}} / {{slideCount}}" data-cycle-slides=".big_thumb_container" ><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize2/IgG_AB108C_Control_19376.jpg" title="SH-SY5Y human neuroblastoma cell line was stained with Goat Anti-Human/Mouse/RatEphrin-B2 Antigen Affinity-purified Polyclonal Antibody (Catalog #AF496,filled histogram) or Normal Goat IgG Isotype Control Antibody(Catalog # AB-108-C, open histogram), followed by Phycoerythrin-conjugatedAnti-Goat IgG Secondary Antibody (Catalog #F0107)." class="big_lightbox"> <img src="//images.novusbio.com/images2/IgG_AB108C_Control_19376.jpg" title="SH-SY5Y human neuroblastoma cell line was stained with Goat Anti-Human/Mouse/RatEphrin-B2 Antigen Affinity-purified Polyclonal Antibody (Catalog #AF496,filled histogram) or Normal Goat IgG Isotype Control Antibody(Catalog # AB-108-C, open histogram), followed by Phycoerythrin-conjugatedAnti-Goat IgG Secondary Antibody (Catalog #F0107)." alt="SH-SY5Y human neuroblastoma cell line was stained with Goat Anti-Human/Mouse/RatEphrin-B2 Antigen Affinity-purified Polyclonal Antibody (Catalog #AF496,filled histogram) or Normal Goat IgG Isotype Control Antibody(Catalog # AB-108-C, open histogram), followed by Phycoerythrin-conjugatedAnti-Goat IgG Secondary Antibody (Catalog #F0107)." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/ab-108-c_normal-goat-igg-control-8220249504611.jpg" title="Decreased macrophage recruitment correlates with decreased angiogenesis.A) Quantification of BrdU incorporation demonstrates that decreased macrophage infiltration does not significantly correlate with a change in epithelial cell proliferation (N.S. = not significant). B) Quantification of VWF staining reveals decreased blood vessels associated with epithelial structures in mammary glands from mice treated with B/B and anti-CX3CR1 blocking antibody compared with mice treated with B/B and IgG control antibody. *p<0.05. C, D) Representative images of VWF stained mammary glands from mice treated with B/B and either control IgG antibody (C) or anti-CX3CR1 (D). Green = VWF staining, blue = DAPI. Arrows indicate VWF-positive structures. Scale bars represent 50 µM. Results in each figure panel are representative of a minimum of three different mice for each treatment group and genotype. Image collected and cropped by CiteAb from the following open publication (//dx.plos.org/10.1371/journal.pone.0045877), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/ab-108-c_normal-goat-igg-control-8220249504611.jpg" alt="Decreased macrophage recruitment correlates with decreased angiogenesis.A) Quantification of BrdU incorporation demonstrates that decreased macrophage infiltration does not significantly correlate with a change in epithelial cell proliferation (N.S. = not significant). B) Quantification of VWF staining reveals decreased blood vessels associated with epithelial structures in mammary glands from mice treated with B/B and anti-CX3CR1 blocking antibody compared with mice treated with B/B and IgG control antibody. *p<0.05. C, D) Representative images of VWF stained mammary glands from mice treated with B/B and either control IgG antibody (C) or anti-CX3CR1 (D). Green = VWF staining, blue = DAPI. Arrows indicate VWF-positive structures. Scale bars represent 50 µM. Results in each figure panel are representative of a minimum of three different mice for each treatment group and genotype. Image collected and cropped by CiteAb from the following open publication (//dx.plos.org/10.1371/journal.pone.0045877), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/ab-108-c_normal-goat-igg-control-8220249505997.jpg" title="iFGFR1 activation in vivo promotes recruitment of CX3CR1-positive macrophages.MMTV-iFGFR1 transgenic mice were treated with B/B in order to analyze the population of macrophages that are recruited to the mammary epithelium during early stages of iFGFR1-induced mammary tumorigenesis. A) MMTV-iFGFR1 mice treated with B/B demonstrated an increase in macrophage recruitment after 10 days as indicated by an increased in the number of F4/80 positive cells. MMTV-iFGFR1 mice treated with anti-CX3CR1 in conjunction with B/B demonstrated a reduction in macrophage recruitment at 10 days indicating that iFGFR1 activation is responsible for recruiting a subset of macrophages that express CX3CR1. ***p<0.0001. Error bars represent SEM. B) Representative image of macrophages associated with budding epithelial structures in mammary glands from mice treated with control IgG antibody. C) Representative image of macrophages associated with budding epithelial structures in mammary glands from mice treated with anti-CX3CR1. Red = F4/80 staining, blue = DAPI. Scale bars represent 50 µM. Results in each figure panel are representative of a minimum of three different mice for each treatment group and genotype. Image collected and cropped by CiteAb from the following open publication (//dx.plos.org/10.1371/journal.pone.0045877), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/ab-108-c_normal-goat-igg-control-8220249505997.jpg" alt="iFGFR1 activation in vivo promotes recruitment of CX3CR1-positive macrophages.MMTV-iFGFR1 transgenic mice were treated with B/B in order to analyze the population of macrophages that are recruited to the mammary epithelium during early stages of iFGFR1-induced mammary tumorigenesis. A) MMTV-iFGFR1 mice treated with B/B demonstrated an increase in macrophage recruitment after 10 days as indicated by an increased in the number of F4/80 positive cells. MMTV-iFGFR1 mice treated with anti-CX3CR1 in conjunction with B/B demonstrated a reduction in macrophage recruitment at 10 days indicating that iFGFR1 activation is responsible for recruiting a subset of macrophages that express CX3CR1. ***p<0.0001. Error bars represent SEM. B) Representative image of macrophages associated with budding epithelial structures in mammary glands from mice treated with control IgG antibody. C) Representative image of macrophages associated with budding epithelial structures in mammary glands from mice treated with anti-CX3CR1. Red = F4/80 staining, blue = DAPI. Scale bars represent 50 µM. Results in each figure panel are representative of a minimum of three different mice for each treatment group and genotype. Image collected and cropped by CiteAb from the following open publication (//dx.plos.org/10.1371/journal.pone.0045877), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/ab-108-c_normal-goat-igg-control-44202415425093.jpg" title="iFGFR1 activation in vivo promotes recruitment of CX3CR1-positive macrophages.MMTV-iFGFR1 transgenic mice were treated with B/B in order to analyze the population of macrophages that are recruited to the mammary epithelium during early stages of iFGFR1-induced mammary tumorigenesis. A) MMTV-iFGFR1 mice treated with B/B demonstrated an increase in macrophage recruitment after 10 days as indicated by an increased in the number of F4/80 positive cells. MMTV-iFGFR1 mice treated with anti-CX3CR1 in conjunction with B/B demonstrated a reduction in macrophage recruitment at 10 days indicating that iFGFR1 activation is responsible for recruiting a subset of macrophages that express CX3CR1. ***p<0.0001. Error bars represent SEM. B) Representative image of macrophages associated with budding epithelial structures in mammary glands from mice treated with control IgG antibody. C) Representative image of macrophages associated with budding epithelial structures in mammary glands from mice treated with anti-CX3CR1. Red = F4/80 staining, blue = DAPI. Scale bars represent 50 µM. Results in each figure panel are representative of a minimum of three different mice for each treatment group and genotype. Image collected and cropped by CiteAb from the following open publication (//dx.plos.org/10.1371/journal.pone.0045877), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/ab-108-c_normal-goat-igg-control-44202415425093.jpg" alt="iFGFR1 activation in vivo promotes recruitment of CX3CR1-positive macrophages.MMTV-iFGFR1 transgenic mice were treated with B/B in order to analyze the population of macrophages that are recruited to the mammary epithelium during early stages of iFGFR1-induced mammary tumorigenesis. A) MMTV-iFGFR1 mice treated with B/B demonstrated an increase in macrophage recruitment after 10 days as indicated by an increased in the number of F4/80 positive cells. MMTV-iFGFR1 mice treated with anti-CX3CR1 in conjunction with B/B demonstrated a reduction in macrophage recruitment at 10 days indicating that iFGFR1 activation is responsible for recruiting a subset of macrophages that express CX3CR1. ***p<0.0001. Error bars represent SEM. B) Representative image of macrophages associated with budding epithelial structures in mammary glands from mice treated with control IgG antibody. C) Representative image of macrophages associated with budding epithelial structures in mammary glands from mice treated with anti-CX3CR1. Red = F4/80 staining, blue = DAPI. Scale bars represent 50 µM. Results in each figure panel are representative of a minimum of three different mice for each treatment group and genotype. Image collected and cropped by CiteAb from the following open publication (//dx.plos.org/10.1371/journal.pone.0045877), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/ab-108-c_normal-goat-igg-control-22820241721182.jpg" title="Blocking the tissue inhibitor of metalloproteinase type 1 (TIMP-1) in MSC-CM reduced its pro-oligodendroglial activity on cultured aNSCs. Representative immunocytochemical staining of 2′,3′-cyclic-nucleotide 3′-phosphodiesterase (CNPase)- (A) and GFAP-positive (B) cells treated either with control (no antibody), anti-TIMP-1, or immunoglobulin G (IgG) control pre-incubated with alpha -MEM or MSC-CM after 3 days in culture. (C) Quantification of CNPase- and GFAP-positive (D) cell numbers. Number of experiments n = 4. Statistical significance was calculated using a two-way ANOVA with Bonferroni posttest: * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/32570968), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/ab-108-c_normal-goat-igg-control-22820241721182.jpg" alt="Blocking the tissue inhibitor of metalloproteinase type 1 (TIMP-1) in MSC-CM reduced its pro-oligodendroglial activity on cultured aNSCs. Representative immunocytochemical staining of 2′,3′-cyclic-nucleotide 3′-phosphodiesterase (CNPase)- (A) and GFAP-positive (B) cells treated either with control (no antibody), anti-TIMP-1, or immunoglobulin G (IgG) control pre-incubated with alpha -MEM or MSC-CM after 3 days in culture. (C) Quantification of CNPase- and GFAP-positive (D) cell numbers. Number of experiments n = 4. Statistical significance was calculated using a two-way ANOVA with Bonferroni posttest: * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/32570968), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/ab-108-c_normal-goat-igg-control-22820241715316.jpg" title="Localisation of Sox17 staining in proliferative and secretory phase endometrial tissue and regulation by hormones. Within the proliferative (A) and secretory (B) endometrium, Sox17 localized to the glandular (open arrowheads) and luminal (closed arrowheads) epithelium, with staining appearing in an irregular, patchy, pattern. Smaller inset boxes show relevant IgG negative controls. Imaged at 20x magnification, scale bar = 50 μm. Treatment of endometrial luminal epithelial (ECC-1) cells with 10−8 M estrogen (estradiol)/10−7 M progesterone (medroxyprogesterone acetate) (, *p < 0.05) resulted in an upregulation of Sox17 protein, when compared to untreated, estradiol only (■, E) treatment groups. (C,D) Data presented as mean ± SEM, n = 5. Representative Western immunoblot shown. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/31664088), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/ab-108-c_normal-goat-igg-control-22820241715316.jpg" alt="Localisation of Sox17 staining in proliferative and secretory phase endometrial tissue and regulation by hormones. Within the proliferative (A) and secretory (B) endometrium, Sox17 localized to the glandular (open arrowheads) and luminal (closed arrowheads) epithelium, with staining appearing in an irregular, patchy, pattern. Smaller inset boxes show relevant IgG negative controls. Imaged at 20x magnification, scale bar = 50 μm. Treatment of endometrial luminal epithelial (ECC-1) cells with 10−8 M estrogen (estradiol)/10−7 M progesterone (medroxyprogesterone acetate) (, *p < 0.05) resulted in an upregulation of Sox17 protein, when compared to untreated, estradiol only (■, E) treatment groups. (C,D) Data presented as mean ± SEM, n = 5. Representative Western immunoblot shown. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/31664088), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/ab-108-c_normal-goat-igg-control-22820241721177.jpg" title="Knockdown of SOX17 results in reduced expression in endometrial luminal epithelial cells. Transfection of ECC-1 cells with a CRISPR/Cas9 SOX17 knock down plasmid resulted in decreased SOX17 expression (KD1-5) when compared to untransfected control ECC-1 cells (ECC-1) and ECC-1 cells transfected with a control plasmid (CP). Analysed by Western immunoblot, representative blot shown. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/31664088), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/ab-108-c_normal-goat-igg-control-22820241721177.jpg" alt="Knockdown of SOX17 results in reduced expression in endometrial luminal epithelial cells. Transfection of ECC-1 cells with a CRISPR/Cas9 SOX17 knock down plasmid resulted in decreased SOX17 expression (KD1-5) when compared to untransfected control ECC-1 cells (ECC-1) and ECC-1 cells transfected with a control plasmid (CP). Analysed by Western immunoblot, representative blot shown. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/31664088), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/ab-108-c_normal-goat-igg-control-22820241795617.jpg" title="Osteoclast resorption of bony interspinous ligaments releases active TGF-beta to drive the progression of ossification in AS patients. e Immunostaining and f quantitative analysis of CD68-positive cells (brown) in the normal and HO-formed interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/ab-108-c_normal-goat-igg-control-22820241795617.jpg" alt="Osteoclast resorption of bony interspinous ligaments releases active TGF-beta to drive the progression of ossification in AS patients. e Immunostaining and f quantitative analysis of CD68-positive cells (brown) in the normal and HO-formed interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/ab-108-c_normal-goat-igg-control-22820241795615.jpg" title="Progression of endochondral heterotopic ossification in AS patients. c Immunostaining and d quantitative analysis of collagen II-positive cells (brown) in the normal and chondrogenic interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panels); 25 μm (bottom panels). Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/ab-108-c_normal-goat-igg-control-22820241795615.jpg" alt="Progression of endochondral heterotopic ossification in AS patients. c Immunostaining and d quantitative analysis of collagen II-positive cells (brown) in the normal and chondrogenic interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panels); 25 μm (bottom panels). Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/ab-108-c_normal-goat-igg-control-22820241795614.jpg" title="Chondrocyte differentiation and cartilage formation in interspinous ligaments of AS patients before calcification. a Hematoxylin and eosin (H&E) staining and b Safranin O–Fast Green (SOFG) staining of normal and chondrogenic interspinous ligaments. In the AS group, the right panels show magnified views of the boxed area in the left panels. Scale bar: 100 μm (two panels on the right side); 25 μm (left panel). c Immunostaining and d quantitative analysis of collagen II-positive cells (brown) in the normal and chondrogenic interspinous ligaments (sagittal view). The bottom panels show a magnified view of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). e Immunostaining and f quantitative analysis of pSmad2/3-positive cells (brown) in the normal and chondrogenic interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). g Immunostaining and h quantitative analysis of pSmad1/5/8-positive cells (brown) in the normal and inflammatory interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panels); 25 μm (bottom panels). C, cartilage; L, ligament Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/ab-108-c_normal-goat-igg-control-22820241795614.jpg" alt="Chondrocyte differentiation and cartilage formation in interspinous ligaments of AS patients before calcification. a Hematoxylin and eosin (H&E) staining and b Safranin O–Fast Green (SOFG) staining of normal and chondrogenic interspinous ligaments. In the AS group, the right panels show magnified views of the boxed area in the left panels. Scale bar: 100 μm (two panels on the right side); 25 μm (left panel). c Immunostaining and d quantitative analysis of collagen II-positive cells (brown) in the normal and chondrogenic interspinous ligaments (sagittal view). The bottom panels show a magnified view of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). e Immunostaining and f quantitative analysis of pSmad2/3-positive cells (brown) in the normal and chondrogenic interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). g Immunostaining and h quantitative analysis of pSmad1/5/8-positive cells (brown) in the normal and inflammatory interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panels); 25 μm (bottom panels). C, cartilage; L, ligament Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/ab-108-c_normal-goat-igg-control-22820241795611.jpg" title="Progression of endochondral heterotopic ossification in AS patients. i Immunostaining and j quantitative analysis of pSmad2/3-positive cells (brown) in the normal ligaments and endochondral-ossified interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). k Immunostaining and l quantitative analysis of Osterix-positive cells (brown) in the normal and endochondral-ossified interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). m Immunostaining and n quantitative analysis of pSmad1/5/8-positive cells (brown) in the normal and inflammatory interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panels); 25 μm (bottom panels). B, bone; BM, bone marrow; C, cartilage Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/ab-108-c_normal-goat-igg-control-22820241795611.jpg" alt="Progression of endochondral heterotopic ossification in AS patients. i Immunostaining and j quantitative analysis of pSmad2/3-positive cells (brown) in the normal ligaments and endochondral-ossified interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). k Immunostaining and l quantitative analysis of Osterix-positive cells (brown) in the normal and endochondral-ossified interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). m Immunostaining and n quantitative analysis of pSmad1/5/8-positive cells (brown) in the normal and inflammatory interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panels); 25 μm (bottom panels). B, bone; BM, bone marrow; C, cartilage Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/ab-108-c_normal-goat-igg-control-22820241795612.jpg" title="Chondrocyte differentiation and cartilage formation in interspinous ligaments of AS patients before calcification. a Hematoxylin and eosin (H&E) staining and b Safranin O–Fast Green (SOFG) staining of normal and chondrogenic interspinous ligaments. In the AS group, the right panels show magnified views of the boxed area in the left panels. Scale bar: 100 μm (two panels on the right side); 25 μm (left panel). c Immunostaining and d quantitative analysis of collagen II-positive cells (brown) in the normal and chondrogenic interspinous ligaments (sagittal view). The bottom panels show a magnified view of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). e Immunostaining and f quantitative analysis of pSmad2/3-positive cells (brown) in the normal and chondrogenic interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). g Immunostaining and h quantitative analysis of pSmad1/5/8-positive cells (brown) in the normal and inflammatory interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panels); 25 μm (bottom panels). C, cartilage; L, ligament Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/ab-108-c_normal-goat-igg-control-22820241795612.jpg" alt="Chondrocyte differentiation and cartilage formation in interspinous ligaments of AS patients before calcification. a Hematoxylin and eosin (H&E) staining and b Safranin O–Fast Green (SOFG) staining of normal and chondrogenic interspinous ligaments. In the AS group, the right panels show magnified views of the boxed area in the left panels. Scale bar: 100 μm (two panels on the right side); 25 μm (left panel). c Immunostaining and d quantitative analysis of collagen II-positive cells (brown) in the normal and chondrogenic interspinous ligaments (sagittal view). The bottom panels show a magnified view of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). e Immunostaining and f quantitative analysis of pSmad2/3-positive cells (brown) in the normal and chondrogenic interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). g Immunostaining and h quantitative analysis of pSmad1/5/8-positive cells (brown) in the normal and inflammatory interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panels); 25 μm (bottom panels). C, cartilage; L, ligament Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/ab-108-c_normal-goat-igg-control-2282024179566.jpg" title="Elevated TGF-beta levels in the early inflammatory stage of AS. a Hematoxylin and eosin (H&E) staining and b Safranin O–Fast Green (SOFG) staining of normal and inflamed interspinous ligaments. In the AS group, the right panels show magnified views of the boxed area in the left panels. Scale bar: 100 μm (two panels on the right); 25 μm (left panel). c Immunostaining and d quantitative analysis of CD68-positive cells (brown) in the normal and inflamed interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panels); 25 μm (bottom panels). e Immunostaining and f quantitative analysis of pSmad2/3-positive cells (brown) in the normal and inflamed interspinous ligaments (sagittal view) in normal ligaments and inflammatory ligaments. The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panels); 25 μm (bottom panels). g Immunostaining and h quantitative analysis of pSmad1/5/8-positive cells (brown) in the normal and inflamed interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panels); 25 μm (bottom panels) Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/ab-108-c_normal-goat-igg-control-2282024179566.jpg" alt="Elevated TGF-beta levels in the early inflammatory stage of AS. a Hematoxylin and eosin (H&E) staining and b Safranin O–Fast Green (SOFG) staining of normal and inflamed interspinous ligaments. In the AS group, the right panels show magnified views of the boxed area in the left panels. Scale bar: 100 μm (two panels on the right); 25 μm (left panel). c Immunostaining and d quantitative analysis of CD68-positive cells (brown) in the normal and inflamed interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panels); 25 μm (bottom panels). e Immunostaining and f quantitative analysis of pSmad2/3-positive cells (brown) in the normal and inflamed interspinous ligaments (sagittal view) in normal ligaments and inflammatory ligaments. The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panels); 25 μm (bottom panels). g Immunostaining and h quantitative analysis of pSmad1/5/8-positive cells (brown) in the normal and inflamed interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panels); 25 μm (bottom panels) Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/ab-108-c_normal-goat-igg-control-2282024179567.jpg" title="Osteoclast resorption of bony interspinous ligaments releases active TGF-beta to drive the progression of ossification in AS patients. g Immunostaining and h quantitative analysis of pSmad2/3-positive cells in the normal and HO-formed interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). i Immunostaining and j quantitative analysis of Osterix-positive cells (brown) in the normal and HO-formed interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel).Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/ab-108-c_normal-goat-igg-control-2282024179567.jpg" alt="Osteoclast resorption of bony interspinous ligaments releases active TGF-beta to drive the progression of ossification in AS patients. g Immunostaining and h quantitative analysis of pSmad2/3-positive cells in the normal and HO-formed interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). i Immunostaining and j quantitative analysis of Osterix-positive cells (brown) in the normal and HO-formed interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel).Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/ab-108-c_normal-goat-igg-control-2282024179560.jpg" title="Progression of endochondral heterotopic ossification in AS patients.g Immunostaining and h quantitative analysis of the number of CD68-positive osteoclast (brown) surface (OCS) per bone surface (BS). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). i Immunostaining and j quantitative analysis of pSmad2/3-positive cells (brown) in the normal ligaments and endochondral-ossified interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). k Immunostaining and l quantitative analysis of Osterix-positive cells (brown) in the normal and endochondral-ossified interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). m Immunostaining and n quantitative analysis of pSmad1/5/8-positive cells (brown) in the normal and inflammatory interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panels); 25 μm (bottom panels). B, bone; BM, bone marrow; C, cartilage Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/ab-108-c_normal-goat-igg-control-2282024179560.jpg" alt="Progression of endochondral heterotopic ossification in AS patients.g Immunostaining and h quantitative analysis of the number of CD68-positive osteoclast (brown) surface (OCS) per bone surface (BS). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). i Immunostaining and j quantitative analysis of pSmad2/3-positive cells (brown) in the normal ligaments and endochondral-ossified interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). k Immunostaining and l quantitative analysis of Osterix-positive cells (brown) in the normal and endochondral-ossified interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). m Immunostaining and n quantitative analysis of pSmad1/5/8-positive cells (brown) in the normal and inflammatory interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panels); 25 μm (bottom panels). B, bone; BM, bone marrow; C, cartilage Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div></div><div id="ss_next0" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-0" class="cycle-circle-pager"></div><div id="image-caption-AB-108-C"></div> </div><div class="review_publication_wrapper forcol3"></div> <div class="product-attributes"><div class="field not3column"><label>Reactivity:</label><div class="value"><span title="Goat">Gt</span><div class="myModal">Species Glossary</div></div></div><div class="forcol3 bottom_margin"><strong>Reactivity:</strong> <span title="Goat">Gt</span></div><div class="field not3column"><label>Applications:</label><div class="value"><span class="application-tooltip-text" title="Control">Ctrl</span></div></div><div class="forcol3 bottom_margin"><strong>Applications:</strong> <span class="application-tooltip-text" title="Control">Ctrl</span></div><div class="field not3column"><label>Host:</label><div class="value">Goat Polyclonal</div></div><div class="forcol3 bottom_margin"><strong>Host:</strong> Goat Polyclonal</div><div class="field not3column"><label>Conjugate:</label><div class="value">Unconjugated  <div class="list_expand not3column options_closed" data-name="Conjugates" data-wrapper-type=".conjugates_wrapper">Available Conjugates: <div class="expander option_closed"></div></div></div></div> </div><div class="forcol3 option_buttons_block"><button class="options_button" data-type="conjugates">Conjugates</button></div><div class="conjugates_wrapper" data-title="Goat IgG Isotype Control [Unconjugated]" data-catnum="AB-108-C"><table class="scf_table"> <thead> <tr> <th>Conjugate</th> <th>Catalog #</th> <th class="head_avail">Availability</th> <th>Size</th> <th class="col_price">Price</th> </tr> </thead> <tbody><tr class="popup_sku" data-sku="IC108G"> <td><a href="/products/igg-isotype-control_ic108g">Alexa Fluor 488</a></td> <td><a href="/products/igg-isotype-control_ic108g">IC108G</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC108R"> <td><a href="/products/igg-isotype-control_ic108r">Alexa Fluor 647</a></td> <td><a href="/products/igg-isotype-control_ic108r">IC108R</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC108N"> <td><a href="/products/igg-isotype-control_ic108n">Alexa Fluor 700</a></td> <td><a href="/products/igg-isotype-control_ic108n">IC108N</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC108A"> <td><a href="/products/igg-isotype-control_ic108a">Allophycocyanin</a></td> <td><a href="/products/igg-isotype-control_ic108a">IC108A</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="BAF108"> <td><a href="/products/igg-isotype-control_baf108">Biotin</a></td> <td><a href="/products/igg-isotype-control_baf108">BAF108</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC108F"> <td><a href="/products/igg-isotype-control_ic108f">Fluorescein</a></td> <td><a href="/products/igg-isotype-control_ic108f">IC108F</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC108C"> <td><a href="/products/igg-isotype-control_ic108c">PerCP (Peridinin-chlorophyll Protein Complex)</a></td> <td><a href="/products/igg-isotype-control_ic108c">IC108C</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC108P"> <td><a href="/products/igg-isotype-control_ic108p">Phycoerythrin</a></td> <td><a href="/products/igg-isotype-control_ic108p">IC108P</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr> <tr class="scf_footer"> <td colspan="5"><div class="expander option_opened"></div></td> </tr> </tbody> </table> <div class="popup_skus" data-skus='["IC108G","IC108R","IC108N","IC108A","BAF108","IC108F","IC108C","IC108P"]' data-rendered="false"></div></div><div class="product-attributes" style="margin-top:-10px;padding-top:0px;"><div class="field not3column"><label>&nbsp</label><div class="value"><div class="list_expand not3column options_closed" data-name="Formulations" data-wrapper-type=".formulations_wrapper" style="margin-left:0px;">Available Formulations <div class="expander option_closed"></div></div></div></div></div><div class="forcol3 option_buttons_block"><button class="options_button" data-type="formulations">Formulations</button></div><div class="formulations_wrapper" data-title="Goat IgG Isotype Control [Unconjugated]" data-catnum="AB-108-C"><table class="scf_table"> <thead> <tr> <th>Formulation</th> <th>Catalog #</th> <th>Availability</th> <th>Price</th> <th> </th> </tr> </thead> <tbody><tr class="popup_sku" data-sku="IC108A"> <td><a href="/products/igg-isotype-control_ic108a">Carrier Free</a></td> <td><a href="/products/igg-isotype-control_ic108a">IC108A</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/416214"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC108C"> <td><a href="/products/igg-isotype-control_ic108c">Carrier Free</a></td> <td><a href="/products/igg-isotype-control_ic108c">IC108C</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/416215"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC108F"> <td><a href="/products/igg-isotype-control_ic108f">Carrier Free</a></td> <td><a href="/products/igg-isotype-control_ic108f">IC108F</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/416216"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC108G"> <td><a href="/products/igg-isotype-control_ic108g">Carrier Free</a></td> <td><a href="/products/igg-isotype-control_ic108g">IC108G</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/416217"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC108N"> <td><a href="/products/igg-isotype-control_ic108n">Carrier Free</a></td> <td><a href="/products/igg-isotype-control_ic108n">IC108N</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/416218"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC108P"> <td><a href="/products/igg-isotype-control_ic108p">Carrier Free</a></td> <td><a href="/products/igg-isotype-control_ic108p">IC108P</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/416219"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC108R"> <td><a href="/products/igg-isotype-control_ic108r">Carrier Free</a></td> <td><a href="/products/igg-isotype-control_ic108r">IC108R</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/493136"><div class="purchase_cart"></div></a></td> </tr> <tr class="scf_footer"> <td colspan="5"><div class="expander option_opened"></div></td> </tr> </tbody> </table> <div class="popup_skus" data-skus='["IC108A","IC108C","IC108F","IC108G","IC108N","IC108P","IC108R"]' data-rendered="false"></div></div> <div class="compare_block"><input type="checkbox" class="search_compare_checkbox" data-compare='{"Catalog #":"AB-108-C","Product Name":"Normal Goat IgG Control","Description":"","Reactivity":"Goat","Applications":"Ctrl","Source":"","Purification":"","Immunogen":"NA","Citations":"626","Purity":"","Activity":"","Accession #":"","N-terminal Sequence Analysis":"","Predicated Molecular Mass":"","SDS Page":"","Assay Type":"","Format":"","Assay Length":"","Sample Type and Volume Required":"","Sensitivity":"","Interference":"","Datasheet":"<a href=\"\/products\/igg-isotype-control_ab-108-c\">view datasheet<\/a>","Price":"Price Not Shown"}'><div class="search_compare">compare</div> <div class="search_compare_text">(select up to 3 products from this page to compare)</div> </div> <div class="clear"></div> </div><div class="new-search-result search-result-wrapper" > <div class="name"><span> <div class="catalog_number_wrapper not3column"> <a href="/products/igg1-isotype-control-11711_mab002">MAB002</a> </div><h2 class="col3_hdr"><a data-brand="rnd" data-id="MAB002" data-name="Mouse IgG1 Isotype Control (11711) [Unconjugated]" data-position="2" class="ecommerce_link" href="/products/igg1-isotype-control-11711_mab002" title="Mouse IgG1 Isotype Control (11711) [Unconjugated]" ><span> Mouse IgG1 Isotype Control (11711) [Unconjugated]</span></a></div></h2> <div class="sub-header"> <div class="flourish_left"></div> <div class="flourish_right"></div><div class="prod_details_section"> <div class="segment"> <a title="1 Review for this product" href="/products/igg1-isotype-control-11711_mab002#ReviewsSection"><span class="stars5"></span> (1 Review)</a> </div> <div class="segment"> <a title="412 Publications specific to this product" href="/products/igg1-isotype-control-11711_mab002#PublicationSection"><span class="publications"></span> (412 Publications)</a> </div> <div class="segment" style="float:right;"> <strong>500 μg</strong><span class="product_price" data-sku="MAB002"></span> </div> </div> </div> <div class="images"> <div class="catalog_number_wrapper_col3 forcol3"> <a href="/products/igg1-isotype-control-11711_mab002">MAB002</a> </div><div id="ss_prev1" class="cycle-pager"><div class="pager_left_on"></div></div><div class="cycle-slideshow slideshows" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-1" data-cycle-prev="#ss_prev1" data-cycle-next="#ss_next1" data-cycle-caption="#image-caption-MAB002" data-cycle-caption-template="Image {{slideNum}} / {{slideCount}}" data-cycle-slides=".big_thumb_container" ><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize2/IgG1_MAB002_Control_19369.jpg" title="Human peripheral blood mononuclear cells (PBMCs) werestained with Mouse Anti-Human LILRA6/CD85b Monoclonal Antibody (Catalog #MAB8656,filled histogram) or Mouse IgG1 Isotype Control Antibody (Catalog # MAB002, openhistogram), followed by Allophycocyanin-conjugated Anti-Mouse IgG SecondaryAntibody (Catalog # F0101B)." class="big_lightbox"> <img src="//images.novusbio.com/images2/IgG1_MAB002_Control_19369.jpg" title="Human peripheral blood mononuclear cells (PBMCs) werestained with Mouse Anti-Human LILRA6/CD85b Monoclonal Antibody (Catalog #MAB8656,filled histogram) or Mouse IgG1 Isotype Control Antibody (Catalog # MAB002, openhistogram), followed by Allophycocyanin-conjugated Anti-Mouse IgG SecondaryAntibody (Catalog # F0101B)." alt="Human peripheral blood mononuclear cells (PBMCs) werestained with Mouse Anti-Human LILRA6/CD85b Monoclonal Antibody (Catalog #MAB8656,filled histogram) or Mouse IgG1 Isotype Control Antibody (Catalog # MAB002, openhistogram), followed by Allophycocyanin-conjugated Anti-Mouse IgG SecondaryAntibody (Catalog # F0101B)." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/mab002_mouse-igg1-isotype-control-clone-11711-41202410484325.jpg" title="EC and PC ICAM-1 expression and effects of CD18 blocking on neutrophil adhesion.ICAM-1 expression on (A) EC or (D) PC monolayers before and after 4 hr IL-1 beta activation was assessed by flow cytometry (IgG labeled control white). ICAM-1 expression on (B,C) EC and (E,F) PC following 4 hr IL-1 beta activation was imaged using confocal microscopy. Scale bars are 20 µm. (G) Neutrophil adhesion inhibition to IL-1 beta activated EC or PC monolayers. Freshly isolated neutrophils were pre-incubated with anti-Mac-1 or anti-LFA-1 antibodies and seeded onto EC or PC monolayers (activated for 4 with IL-1 beta ) in Sykes-Moore chambers and allowed to adhere prior to counting. Bars represent average neutrophil adhesion ± SEM. *P<0.05, when compared to the no block control. Image collected and cropped by CiteAb from the following publication (//dx.plos.org/10.1371/journal.pone.0060025), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/mab002_mouse-igg1-isotype-control-clone-11711-41202410484325.jpg" alt="EC and PC ICAM-1 expression and effects of CD18 blocking on neutrophil adhesion.ICAM-1 expression on (A) EC or (D) PC monolayers before and after 4 hr IL-1 beta activation was assessed by flow cytometry (IgG labeled control white). ICAM-1 expression on (B,C) EC and (E,F) PC following 4 hr IL-1 beta activation was imaged using confocal microscopy. Scale bars are 20 µm. (G) Neutrophil adhesion inhibition to IL-1 beta activated EC or PC monolayers. Freshly isolated neutrophils were pre-incubated with anti-Mac-1 or anti-LFA-1 antibodies and seeded onto EC or PC monolayers (activated for 4 with IL-1 beta ) in Sykes-Moore chambers and allowed to adhere prior to counting. Bars represent average neutrophil adhesion ± SEM. *P<0.05, when compared to the no block control. Image collected and cropped by CiteAb from the following publication (//dx.plos.org/10.1371/journal.pone.0060025), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/mab002_mouse-igg1-isotype-control-clone-11711-41202410484329.jpg" title="EC and PC ICAM-1 expression and effects of CD18 blocking on neutrophil adhesion.ICAM-1 expression on (A) EC or (D) PC monolayers before and after 4 hr IL-1 beta activation was assessed by flow cytometry (IgG labeled control white). ICAM-1 expression on (B,C) EC and (E,F) PC following 4 hr IL-1 beta activation was imaged using confocal microscopy. Scale bars are 20 µm. (G) Neutrophil adhesion inhibition to IL-1 beta activated EC or PC monolayers. Freshly isolated neutrophils were pre-incubated with anti-Mac-1 or anti-LFA-1 antibodies and seeded onto EC or PC monolayers (activated for 4 with IL-1 beta ) in Sykes-Moore chambers and allowed to adhere prior to counting. Bars represent average neutrophil adhesion ± SEM. *P<0.05, when compared to the no block control. Image collected and cropped by CiteAb from the following publication (//dx.plos.org/10.1371/journal.pone.0060025), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/mab002_mouse-igg1-isotype-control-clone-11711-41202410484329.jpg" alt="EC and PC ICAM-1 expression and effects of CD18 blocking on neutrophil adhesion.ICAM-1 expression on (A) EC or (D) PC monolayers before and after 4 hr IL-1 beta activation was assessed by flow cytometry (IgG labeled control white). ICAM-1 expression on (B,C) EC and (E,F) PC following 4 hr IL-1 beta activation was imaged using confocal microscopy. Scale bars are 20 µm. (G) Neutrophil adhesion inhibition to IL-1 beta activated EC or PC monolayers. Freshly isolated neutrophils were pre-incubated with anti-Mac-1 or anti-LFA-1 antibodies and seeded onto EC or PC monolayers (activated for 4 with IL-1 beta ) in Sykes-Moore chambers and allowed to adhere prior to counting. Bars represent average neutrophil adhesion ± SEM. *P<0.05, when compared to the no block control. Image collected and cropped by CiteAb from the following publication (//dx.plos.org/10.1371/journal.pone.0060025), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/mab002_mouse-igg1-isotype-control-clone-11711-4120241048247.jpg" title="miR-720 maintains the migratory and invasive properties of MDA-MB-231 cells. MDA-MB-231 cells were transfected with 50 nM anti-miR-720 or anti-miR-negative control (Ctrl) for 48 h. Either RNA was isolated (a) or transfected cells subjected to functional assays (b–e). a miR-720 levels. RNA was subjected to RT-qPCR for miR-720. Control condition (Ctrl) was set to 1.0 (mean ± SD from three independent experiments). b Migration assay. Transfected cells were subjected to a migration assay in a Boyden chamber over a 24-h period. The cells that migrated through the chamber were quantified using crystal violet staining. Ctrl was set to 100 % (mean ± SD from three independent experiments). c Matrigel assay. Transfected cells were grown in Matrigel for 11–15 days and then photographed using a Nikon eclipse TS100 microscope at 10× magnification. Scale bar = 100 μm. Representative images of two independent experiments with similar results are shown (left panels). The number of branched colonies were counted. The count in the control sample was set to 1.0 (right panel). d Transendothelial migration assay. Transfected MDA-MB-231 cells were plated in a Boyden chamber that had been coated with a confluent monolayer of HUVEC cells, and the cancer cells that invaded through the HUVEC layer over a 24-h period were quantified using crystal violet staining. Ctrl value for transendothelial (transendo.) migration was set to 100 % (mean ± SD from three independent experiments) and relative (Rel.) migration values given. e ATP assay. Transfected cells were grown for 24 h and ATP levels were measured using an ATPlite 1Step assay. Ctrl was set to 100 % (mean ± SD from three independent experiments). *P < 0.05, ***P < 0.001, Student’s t test. Not sig. not significant Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/27039296), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/mab002_mouse-igg1-isotype-control-clone-11711-4120241048247.jpg" alt="miR-720 maintains the migratory and invasive properties of MDA-MB-231 cells. MDA-MB-231 cells were transfected with 50 nM anti-miR-720 or anti-miR-negative control (Ctrl) for 48 h. Either RNA was isolated (a) or transfected cells subjected to functional assays (b–e). a miR-720 levels. RNA was subjected to RT-qPCR for miR-720. Control condition (Ctrl) was set to 1.0 (mean ± SD from three independent experiments). b Migration assay. Transfected cells were subjected to a migration assay in a Boyden chamber over a 24-h period. The cells that migrated through the chamber were quantified using crystal violet staining. Ctrl was set to 100 % (mean ± SD from three independent experiments). c Matrigel assay. Transfected cells were grown in Matrigel for 11–15 days and then photographed using a Nikon eclipse TS100 microscope at 10× magnification. Scale bar = 100 μm. Representative images of two independent experiments with similar results are shown (left panels). The number of branched colonies were counted. The count in the control sample was set to 1.0 (right panel). d Transendothelial migration assay. Transfected MDA-MB-231 cells were plated in a Boyden chamber that had been coated with a confluent monolayer of HUVEC cells, and the cancer cells that invaded through the HUVEC layer over a 24-h period were quantified using crystal violet staining. Ctrl value for transendothelial (transendo.) migration was set to 100 % (mean ± SD from three independent experiments) and relative (Rel.) migration values given. e ATP assay. Transfected cells were grown for 24 h and ATP levels were measured using an ATPlite 1Step assay. Ctrl was set to 100 % (mean ± SD from three independent experiments). *P < 0.05, ***P < 0.001, Student’s t test. Not sig. not significant Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/27039296), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/mab002_mouse-igg1-isotype-control-clone-11711-22820241721173.jpg" title="Monoclonal ASM antibody (23A12C3) inhibits pathogenic Th17 cell differentiation and protects neuropathological features in APP/PS1 mice. e Representative flow cytometry plot and graph displaying the calculated percentage and mean fluorescent intensity of Th17 cells (CD4+ IL17A+) differentiated from CD4+ T cell in each group (Control, n = 5; Smpd1ox/ox serum/con IgG ab, n = 10; Smpd1ox/ox serum/23A12C3, n = 8). f Western blotting for p-Stat3, p-JNK, p-AKT, p-mTOR in Th17 cells differentiated from CD4+ T cell in each group (n = 4/group). g ASM activity in plasma (n = 5/group). h Percentage of Th17 cells in the spleen, blood, and brain by flow cytometry (n = 5/group). i Quantification of microglia (Iba-1) and astrocyte (GFAP) (n = 5/group). j mRNA levels of inflammatory markers in the cortex and hippocampus (n = 4/group). k Representative immunofluorescence images and quantification of ThioS (A beta plaques) in cortex and hippocampus. Scale bars, 50 μm. (n = 5/group). l Quantification of 6E10 (n = 5/group). m The results of Morris water maze test (n = 10/group). n, o At probe trial day 11, time spent in target platform (n) and the number of times each animal entered the small target zone (o) were analyzed (n = 10/group). p The results of fear-conditioning test (n = 10/group). d–j, m–p One-way analysis of variance, Tukey’s post hoc test. k, l, n Two-tailed student’s t test. All error bars indicate s.e.m. All in vivo data analysis was done at 9-mo-old mice. Source data are provided as a Source Data file. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/36959217), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/mab002_mouse-igg1-isotype-control-clone-11711-22820241721173.jpg" alt="Monoclonal ASM antibody (23A12C3) inhibits pathogenic Th17 cell differentiation and protects neuropathological features in APP/PS1 mice. e Representative flow cytometry plot and graph displaying the calculated percentage and mean fluorescent intensity of Th17 cells (CD4+ IL17A+) differentiated from CD4+ T cell in each group (Control, n = 5; Smpd1ox/ox serum/con IgG ab, n = 10; Smpd1ox/ox serum/23A12C3, n = 8). f Western blotting for p-Stat3, p-JNK, p-AKT, p-mTOR in Th17 cells differentiated from CD4+ T cell in each group (n = 4/group). g ASM activity in plasma (n = 5/group). h Percentage of Th17 cells in the spleen, blood, and brain by flow cytometry (n = 5/group). i Quantification of microglia (Iba-1) and astrocyte (GFAP) (n = 5/group). j mRNA levels of inflammatory markers in the cortex and hippocampus (n = 4/group). k Representative immunofluorescence images and quantification of ThioS (A beta plaques) in cortex and hippocampus. Scale bars, 50 μm. (n = 5/group). l Quantification of 6E10 (n = 5/group). m The results of Morris water maze test (n = 10/group). n, o At probe trial day 11, time spent in target platform (n) and the number of times each animal entered the small target zone (o) were analyzed (n = 10/group). p The results of fear-conditioning test (n = 10/group). d–j, m–p One-way analysis of variance, Tukey’s post hoc test. k, l, n Two-tailed student’s t test. All error bars indicate s.e.m. All in vivo data analysis was done at 9-mo-old mice. Source data are provided as a Source Data file. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/36959217), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div></div><div id="ss_next1" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-1" class="cycle-circle-pager"></div><div id="image-caption-MAB002"></div> </div><div class="review_publication_wrapper forcol3"></div> <div class="product-attributes"><div class="field not3column"><label>Reactivity:</label><div class="value"><span title="Mouse">Mu</span><div class="myModal">Species Glossary</div></div></div><div class="forcol3 bottom_margin"><strong>Reactivity:</strong> <span title="Mouse">Mu</span></div><div class="field not3column"><label>Applications:</label><div class="value"><span class="application-tooltip-text" title="Control">Ctrl</span></div></div><div class="forcol3 bottom_margin"><strong>Applications:</strong> <span class="application-tooltip-text" title="Control">Ctrl</span></div><div class="field not3column"><label>Host:</label><div class="value">Mouse Monoclonal</div></div><div class="forcol3 bottom_margin"><strong>Host:</strong> Mouse Monoclonal</div><div class="field not3column"><label>Conjugate:</label><div class="value">Unconjugated  <div class="list_expand not3column options_closed" data-name="Conjugates" data-wrapper-type=".conjugates_wrapper">Available Conjugates: <div class="expander option_closed"></div></div></div></div> </div><div class="forcol3 option_buttons_block"><button class="options_button" data-type="conjugates">Conjugates</button></div><div class="conjugates_wrapper" data-title="Mouse IgG1 Isotype Control (11711) [Unconjugated]" data-catnum="MAB002"><table class="scf_table"> <thead> <tr> <th>Conjugate</th> <th>Catalog #</th> <th class="head_avail">Availability</th> <th>Size</th> <th class="col_price">Price</th> </tr> </thead> <tbody><tr class="popup_sku" data-sku="IC002V"> <td><a href="/products/igg1-isotype-control-11711_ic002v">Alexa Fluor 405</a></td> <td><a href="/products/igg1-isotype-control-11711_ic002v">IC002V</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC002G"> <td><a href="/products/igg1-isotype-control-11711_ic002g">Alexa Fluor 488</a></td> <td><a href="/products/igg1-isotype-control-11711_ic002g">IC002G</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC002T"> <td><a href="/products/igg1-isotype-control-11711_ic002t">Alexa Fluor 594</a></td> <td><a href="/products/igg1-isotype-control-11711_ic002t">IC002T</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC002R"> <td><a href="/products/igg1-isotype-control-11711_ic002r">Alexa Fluor 647</a></td> <td><a href="/products/igg1-isotype-control-11711_ic002r">IC002R</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC002N"> <td><a href="/products/igg1-isotype-control-11711_ic002n">Alexa Fluor 700</a></td> <td><a href="/products/igg1-isotype-control-11711_ic002n">IC002N</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC002S"> <td><a href="/products/igg1-isotype-control-11711_ic002s">Alexa Fluor 750</a></td> <td><a href="/products/igg1-isotype-control-11711_ic002s">IC002S</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC002A"> <td><a href="/products/igg1-isotype-control-11711_ic002a">Allophycocyanin</a></td> <td><a href="/products/igg1-isotype-control-11711_ic002a">IC002A</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC002B"> <td><a href="/products/igg1-isotype-control-11711_ic002b">Biotin</a></td> <td><a href="/products/igg1-isotype-control-11711_ic002b">IC002B</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC002F"> <td><a href="/products/igg1-isotype-control-11711_ic002f">Fluorescein</a></td> <td><a href="/products/igg1-isotype-control-11711_ic002f">IC002F</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC002C"> <td><a href="/products/igg1-isotype-control-11711_ic002c">PerCP (Peridinin-chlorophyll Protein Complex)</a></td> <td><a href="/products/igg1-isotype-control-11711_ic002c">IC002C</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC002P"> <td><a href="/products/igg1-isotype-control-11711_ic002p">Phycoerythrin</a></td> <td><a href="/products/igg1-isotype-control-11711_ic002p">IC002P</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr> <tr class="scf_footer"> <td colspan="5"><div class="expander option_opened"></div></td> </tr> </tbody> </table> <div class="popup_skus" data-skus='["IC002V","IC002G","IC002T","IC002R","IC002N","IC002S","IC002A","IC002B","IC002F","IC002C","IC002P"]' data-rendered="false"></div></div><div class="product-attributes" style="margin-top:-10px;padding-top:0px;"><div class="field not3column"><label>&nbsp</label><div class="value"><div class="list_expand not3column options_closed" data-name="Formulations" data-wrapper-type=".formulations_wrapper" style="margin-left:0px;">Available Formulations <div class="expander option_closed"></div></div></div></div></div><div class="forcol3 option_buttons_block"><button class="options_button" data-type="formulations">Formulations</button></div><div class="formulations_wrapper" data-title="Mouse IgG1 Isotype Control (11711) [Unconjugated]" data-catnum="MAB002"><table class="scf_table"> <thead> <tr> <th>Formulation</th> <th>Catalog #</th> <th>Availability</th> <th>Price</th> <th> </th> </tr> </thead> <tbody><tr class="popup_sku" data-sku="IC002A"> <td><a href="/products/igg1-isotype-control-11711_ic002a">Carrier Free</a></td> <td><a href="/products/igg1-isotype-control-11711_ic002a">IC002A</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/416153"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC002B"> <td><a href="/products/igg1-isotype-control-11711_ic002b">Carrier Free</a></td> <td><a href="/products/igg1-isotype-control-11711_ic002b">IC002B</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/416154"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC002C"> <td><a href="/products/igg1-isotype-control-11711_ic002c">Carrier Free</a></td> <td><a href="/products/igg1-isotype-control-11711_ic002c">IC002C</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/416155"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC002F"> <td><a href="/products/igg1-isotype-control-11711_ic002f">Carrier Free</a></td> <td><a href="/products/igg1-isotype-control-11711_ic002f">IC002F</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/416156"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC002G"> <td><a href="/products/igg1-isotype-control-11711_ic002g">Carrier Free</a></td> <td><a href="/products/igg1-isotype-control-11711_ic002g">IC002G</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/416157"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC002N"> <td><a href="/products/igg1-isotype-control-11711_ic002n">Carrier Free</a></td> <td><a href="/products/igg1-isotype-control-11711_ic002n">IC002N</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/416158"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC002P"> <td><a href="/products/igg1-isotype-control-11711_ic002p">Carrier Free</a></td> <td><a href="/products/igg1-isotype-control-11711_ic002p">IC002P</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/416159"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC002S"> <td><a href="/products/igg1-isotype-control-11711_ic002s">Carrier Free</a></td> <td><a href="/products/igg1-isotype-control-11711_ic002s">IC002S</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/449243"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC002T"> <td><a href="/products/igg1-isotype-control-11711_ic002t">Carrier Free</a></td> <td><a href="/products/igg1-isotype-control-11711_ic002t">IC002T</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/449251"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC002R"> <td><a href="/products/igg1-isotype-control-11711_ic002r">Carrier Free</a></td> <td><a href="/products/igg1-isotype-control-11711_ic002r">IC002R</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/449262"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC002V"> <td><a href="/products/igg1-isotype-control-11711_ic002v">Carrier Free</a></td> <td><a href="/products/igg1-isotype-control-11711_ic002v">IC002V</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/449273"><div class="purchase_cart"></div></a></td> </tr> <tr class="scf_footer"> <td colspan="5"><div class="expander option_opened"></div></td> </tr> </tbody> </table> <div class="popup_skus" data-skus='["IC002A","IC002B","IC002C","IC002F","IC002G","IC002N","IC002P","IC002S","IC002T","IC002R","IC002V"]' data-rendered="false"></div></div> <div class="compare_block"><input type="checkbox" class="search_compare_checkbox" data-compare='{"Catalog #":"MAB002","Product Name":"Mouse IgG1 Isotype Control","Description":"","Reactivity":"Mouse","Applications":"Ctrl","Source":"","Purification":"","Immunogen":"KLH","Citations":"412","Purity":"","Activity":"","Accession #":"","N-terminal Sequence Analysis":"","Predicated Molecular Mass":"","SDS Page":"","Assay Type":"","Format":"","Assay Length":"","Sample Type and Volume Required":"","Sensitivity":"","Interference":"","Datasheet":"<a href=\"\/products\/igg1-isotype-control-11711_mab002\">view datasheet<\/a>","Price":"Price Not Shown"}'><div class="search_compare">compare</div> <div class="search_compare_text">(select up to 3 products from this page to compare)</div> </div> <div class="clear"></div> </div><div class="new-search-result search-result-wrapper" > <div class="name"><span> <div class="catalog_number_wrapper not3column"> <a href="/products/igg2a-isotype-control-54447_mab006">MAB006</a> </div><h2 class="col3_hdr"><a data-brand="rnd" data-id="MAB006" data-name="Rat IgG2a Isotype Control (54447) [Unconjugated]" data-position="3" class="ecommerce_link" href="/products/igg2a-isotype-control-54447_mab006" title="Rat IgG2a Isotype Control (54447) [Unconjugated]" ><span> Rat IgG2a Isotype Control (54447) [Unconjugated]</span></a></div></h2> <div class="sub-header"> <div class="flourish_left"></div> <div class="flourish_right"></div><div class="prod_details_section"> <div class="segment"> <a title="1 Review for this product" href="/products/igg2a-isotype-control-54447_mab006#ReviewsSection"><span class="stars5"></span> (1 Review)</a> </div> <div class="segment"> <a title="210 Publications specific to this product" href="/products/igg2a-isotype-control-54447_mab006#PublicationSection"><span class="publications"></span> (210 Publications)</a> </div> <div class="segment" style="float:right;"> <strong>500 μg</strong><span class="product_price" data-sku="MAB006"></span> </div> </div> </div> <div class="images"> <div class="catalog_number_wrapper_col3 forcol3"> <a href="/products/igg2a-isotype-control-54447_mab006">MAB006</a> </div><div id="ss_prev2" class="cycle-pager"><div class="pager_left_on"></div></div><div class="cycle-slideshow slideshows" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-2" data-cycle-prev="#ss_prev2" data-cycle-next="#ss_next2" data-cycle-caption="#image-caption-MAB006" data-cycle-caption-template="Image {{slideNum}} / {{slideCount}}" data-cycle-slides=".big_thumb_container" ><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize2/IgG2A_MAB006_Control_19425.jpg" title="B16-F1 mouse melanoma cell line was stained with RatAnti-Mouse Integrin beta 1/CD29 Monoclonal Antibody (Catalog # MAB2405,filled histogram) or Rat IgG Isotype Control Antibody (Catalog #MAB006,open histogram), followed by Phycoerythrin-conjugated Anti-Rat IgG SecondaryAntibody (Catalog # F0105B)." class="big_lightbox"> <img src="//images.novusbio.com/images2/IgG2A_MAB006_Control_19425.jpg" title="B16-F1 mouse melanoma cell line was stained with RatAnti-Mouse Integrin beta 1/CD29 Monoclonal Antibody (Catalog # MAB2405,filled histogram) or Rat IgG Isotype Control Antibody (Catalog #MAB006,open histogram), followed by Phycoerythrin-conjugated Anti-Rat IgG SecondaryAntibody (Catalog # F0105B)." alt="B16-F1 mouse melanoma cell line was stained with RatAnti-Mouse Integrin beta 1/CD29 Monoclonal Antibody (Catalog # MAB2405,filled histogram) or Rat IgG Isotype Control Antibody (Catalog #MAB006,open histogram), followed by Phycoerythrin-conjugated Anti-Rat IgG SecondaryAntibody (Catalog # F0105B)." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/mab006_rat-igg2a-isotype-control-clone-54447-41202412514850.jpg" title="CCL17-mediated chemotaxis is inhibited in a dose-dependent manner by B202 and B225.EL4 cells were incubated with mouse CCL17 at 2/mL in the presence and absence of (A) B202, (B) B225 (C) CNTO 5516 which is an irrelevant rat:mouse chimeric antibody having a mouse IgG1 Fc or (D) MAB529 (rat antibody) which is a commercial antibody that neutralizes CCL17. Assay was repeated twice with five replicates per sample each time. Data are expressed as chemotactic index (CI = Average RLU from stimulated wells/average RLU from medium control; medium control = CI of 1). Antibody dose used for each sample is indicated along the x axis. Composite CI results from both experiments are shown. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/24339934), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/mab006_rat-igg2a-isotype-control-clone-54447-41202412514850.jpg" alt="CCL17-mediated chemotaxis is inhibited in a dose-dependent manner by B202 and B225.EL4 cells were incubated with mouse CCL17 at 2/mL in the presence and absence of (A) B202, (B) B225 (C) CNTO 5516 which is an irrelevant rat:mouse chimeric antibody having a mouse IgG1 Fc or (D) MAB529 (rat antibody) which is a commercial antibody that neutralizes CCL17. Assay was repeated twice with five replicates per sample each time. Data are expressed as chemotactic index (CI = Average RLU from stimulated wells/average RLU from medium control; medium control = CI of 1). Antibody dose used for each sample is indicated along the x axis. Composite CI results from both experiments are shown. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/24339934), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div></div><div id="ss_next2" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-2" class="cycle-circle-pager"></div><div id="image-caption-MAB006"></div> </div><div class="review_publication_wrapper forcol3"></div> <div class="product-attributes"><div class="field not3column"><label>Reactivity:</label><div class="value"><span title="Rat">Rt</span><div class="myModal">Species Glossary</div></div></div><div class="forcol3 bottom_margin"><strong>Reactivity:</strong> <span title="Rat">Rt</span></div><div class="field not3column"><label>Applications:</label><div class="value"><span class="application-tooltip-text" title="Control">Ctrl</span></div></div><div class="forcol3 bottom_margin"><strong>Applications:</strong> <span class="application-tooltip-text" title="Control">Ctrl</span></div><div class="field not3column"><label>Host:</label><div class="value">Rat Monoclonal</div></div><div class="forcol3 bottom_margin"><strong>Host:</strong> Rat Monoclonal</div><div class="field not3column"><label>Conjugate:</label><div class="value">Unconjugated  <div class="list_expand not3column options_closed" data-name="Conjugates" data-wrapper-type=".conjugates_wrapper">Available Conjugates: <div class="expander option_closed"></div></div></div></div> </div><div class="forcol3 option_buttons_block"><button class="options_button" data-type="conjugates">Conjugates</button></div><div class="conjugates_wrapper" data-title="Rat IgG2a Isotype Control (54447) [Unconjugated]" data-catnum="MAB006"><table class="scf_table"> <thead> <tr> <th>Conjugate</th> <th>Catalog #</th> <th class="head_avail">Availability</th> <th>Size</th> <th class="col_price">Price</th> </tr> </thead> <tbody><tr class="popup_sku" data-sku="IC006V"> <td><a href="/products/igg2a-isotype-control-54447_ic006v">Alexa Fluor 405</a></td> <td><a href="/products/igg2a-isotype-control-54447_ic006v">IC006V</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC006G"> <td><a href="/products/igg2a-isotype-control-54447_ic006g">Alexa Fluor 488</a></td> <td><a href="/products/igg2a-isotype-control-54447_ic006g">IC006G</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC006T"> <td><a href="/products/igg2a-isotype-control-54447_ic006t">Alexa Fluor 594</a></td> <td><a href="/products/igg2a-isotype-control-54447_ic006t">IC006T</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC006R"> <td><a href="/products/igg2a-isotype-control-54447_ic006r">Alexa Fluor 647</a></td> <td><a href="/products/igg2a-isotype-control-54447_ic006r">IC006R</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC006N"> <td><a href="/products/igg2a-isotype-control-54447_ic006n">Alexa Fluor 700</a></td> <td><a href="/products/igg2a-isotype-control-54447_ic006n">IC006N</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC006S"> <td><a href="/products/igg2a-isotype-control-54447_ic006s">Alexa Fluor 750</a></td> <td><a href="/products/igg2a-isotype-control-54447_ic006s">IC006S</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC006A"> <td><a href="/products/igg2a-isotype-control-54447_ic006a">Allophycocyanin</a></td> <td><a href="/products/igg2a-isotype-control-54447_ic006a">IC006A</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC006B"> <td><a href="/products/igg2a-isotype-control-54447_ic006b">Biotin</a></td> <td><a href="/products/igg2a-isotype-control-54447_ic006b">IC006B</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC006F"> <td><a href="/products/igg2a-isotype-control-54447_ic006f">Fluorescein</a></td> <td><a href="/products/igg2a-isotype-control-54447_ic006f">IC006F</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC006C"> <td><a href="/products/igg2a-isotype-control-54447_ic006c">PerCP (Peridinin-chlorophyll Protein Complex)</a></td> <td><a href="/products/igg2a-isotype-control-54447_ic006c">IC006C</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC006P"> <td><a href="/products/igg2a-isotype-control-54447_ic006p">Phycoerythrin</a></td> <td><a href="/products/igg2a-isotype-control-54447_ic006p">IC006P</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr> <tr class="scf_footer"> <td colspan="5"><div class="expander option_opened"></div></td> </tr> </tbody> </table> <div class="popup_skus" data-skus='["IC006V","IC006G","IC006T","IC006R","IC006N","IC006S","IC006A","IC006B","IC006F","IC006C","IC006P"]' data-rendered="false"></div></div><div 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search-result-wrapper" > <div class="name"><span> <div class="catalog_number_wrapper not3column"> <a href="/products/igg-isotype-control_ab-105-c">AB-105-C</a> </div><h2 class="col3_hdr"><a data-brand="rnd" data-id="AB-105-C" data-name="Rabbit IgG Isotype Control [Unconjugated]" data-position="4" class="ecommerce_link" href="/products/igg-isotype-control_ab-105-c" title="Rabbit IgG Isotype Control [Unconjugated]" ><span> Rabbit IgG Isotype Control [Unconjugated]</span></a></div></h2> <div class="sub-header"> <div class="flourish_left"></div> <div class="flourish_right"></div><div class="prod_details_section"> <div class="segment"> <a title="2 Reviews for this product" href="/products/igg-isotype-control_ab-105-c#ReviewsSection"><span class="stars5"></span> (2 Reviews)</a> </div> <div class="segment"> <a title="174 Publications specific to this product" href="/products/igg-isotype-control_ab-105-c#PublicationSection"><span class="publications"></span> (174 Publications)</a> </div> <div class="segment" style="float:right;"> <strong>1 mg</strong><span class="product_price" data-sku="AB-105-C"></span> </div> </div> </div> <div class="images"> <div class="catalog_number_wrapper_col3 forcol3"> <a href="/products/igg-isotype-control_ab-105-c">AB-105-C</a> </div><div id="ss_prev3" class="cycle-pager"><div class="pager_left_on"></div></div><div class="cycle-slideshow slideshows" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-3" data-cycle-prev="#ss_prev3" data-cycle-next="#ss_next3" data-cycle-caption="#image-caption-AB-105-C" data-cycle-caption-template="Image {{slideNum}} / {{slideCount}}" data-cycle-slides=".big_thumb_container" ><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize2/IgG_AB105C_Control_20512.jpg" title="HepG2 human hepatocellular carcinoma cell line was stained with Rabbit Anti-Human Klotho beta Monoclonal Antibody (Catalog # MAB58891, filled histogram) or Rabbit IgG Isotype Control Antibody (Catalog # AB-105-C, open histogram), followed by Allophycocyanin-conjugated Anti-Rabbit IgG Secondary Antibody (Catalog # F0111). View our protocol for Staining Membrane-associated Proteins." class="big_lightbox"> <img src="//images.novusbio.com/images2/IgG_AB105C_Control_20512.jpg" title="HepG2 human hepatocellular carcinoma cell line was stained with Rabbit Anti-Human Klotho beta Monoclonal Antibody (Catalog # MAB58891, filled histogram) or Rabbit IgG Isotype Control Antibody (Catalog # AB-105-C, open histogram), followed by Allophycocyanin-conjugated Anti-Rabbit IgG Secondary Antibody (Catalog # F0111). View our protocol for Staining Membrane-associated Proteins." alt="HepG2 human hepatocellular carcinoma cell line was stained with Rabbit Anti-Human Klotho beta Monoclonal Antibody (Catalog # MAB58891, filled histogram) or Rabbit IgG Isotype Control Antibody (Catalog # AB-105-C, open histogram), followed by Allophycocyanin-conjugated Anti-Rabbit IgG Secondary Antibody (Catalog # F0111). View our protocol for Staining Membrane-associated Proteins." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/ab-105-c_normal-rabbit-igg-control-8220249504630.jpg" title="<b>Biological Strategies Validation. </b>pSTAT5, but not NS1, interacts with the MCM complex.(A) Immunoprecipitation (IP) assay. Cell lysates of NS1Flag-expressing UT7/Epo-S1 cells were prepared for pull-down assays with either anti-Flag-conjugated beads or control beads. Immunoprecipitated proteins were examined for the presence of MCM2 by Western blotting. Blots were reprobed with rabbit anti-pSTAT5(Y694), anti-E2F5, and anti-Flag antibodies. Detection of E2F5 was used as a positive control for NS1 IP. (B) Co-IP assay. UT7/Epo-S1 cells were collected, washed, and lysed with RIPA buffer. After centrifugation, the supernatant was incubated with either rabbit anti-pSTAT5(Y694) or control IgG antibody. Immunoprecipitated proteins were blotted for the presence of the MCM complex with an anti-MCM5 antibody and for pSTAT5 with rabbit anti-pSTAT5(Y694). (C) Reverse Co-IP assay. Reverse Co-IP was performed with an anti-MCM5 antibody. Immunoprecipitated proteins were examined for pSTAT5, MCM2, and MCM5, respectively. (D) Co-IP of lysates treated with DNase. UT7/Epo-S1 cell lysates, either treated or untreated with DNase (750 units of Benzonase) were incubated with anti-pSTAT5(Y694) or control IgG antibodies for Co-IP assay, and immunoprecipitated proteins were examined for MCM2 by Western blot analysis. (E-H) Immunofluorescence analysis. (E&F) Mock- or B19V-infected CD36+ EPCs were co-stained with rabbit anti-STAT5 and mouse anti-MCM2 antibodies, followed by (E) incubation with respective secondary antibodies, or by (F) proximal ligation assay, which produces amplified signal for labeled molecules in close proximity. (G) CD36+ EPCs were incubated with either DMSO or pimozide (at 30 μM) for 2 days. And then the cells were co-stained with rabbit anti-STAT5 and mouse anti-MCM2 antibodies for proximity ligation assay. (H) Infected EPCs were stained with an anti-capsid antibody. Confocal images were taken with an Eclipse C1 Plus (Nikon) microscope at 100 × magnification. Image collected and cropped by CiteAb from the following open publication (//dx.plos.org/10.1371/journal.ppat.1006370), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/ab-105-c_normal-rabbit-igg-control-8220249504630.jpg" alt="<b>Biological Strategies Validation. </b>pSTAT5, but not NS1, interacts with the MCM complex.(A) Immunoprecipitation (IP) assay. Cell lysates of NS1Flag-expressing UT7/Epo-S1 cells were prepared for pull-down assays with either anti-Flag-conjugated beads or control beads. Immunoprecipitated proteins were examined for the presence of MCM2 by Western blotting. Blots were reprobed with rabbit anti-pSTAT5(Y694), anti-E2F5, and anti-Flag antibodies. Detection of E2F5 was used as a positive control for NS1 IP. (B) Co-IP assay. UT7/Epo-S1 cells were collected, washed, and lysed with RIPA buffer. After centrifugation, the supernatant was incubated with either rabbit anti-pSTAT5(Y694) or control IgG antibody. Immunoprecipitated proteins were blotted for the presence of the MCM complex with an anti-MCM5 antibody and for pSTAT5 with rabbit anti-pSTAT5(Y694). (C) Reverse Co-IP assay. Reverse Co-IP was performed with an anti-MCM5 antibody. Immunoprecipitated proteins were examined for pSTAT5, MCM2, and MCM5, respectively. (D) Co-IP of lysates treated with DNase. UT7/Epo-S1 cell lysates, either treated or untreated with DNase (750 units of Benzonase) were incubated with anti-pSTAT5(Y694) or control IgG antibodies for Co-IP assay, and immunoprecipitated proteins were examined for MCM2 by Western blot analysis. (E-H) Immunofluorescence analysis. (E&F) Mock- or B19V-infected CD36+ EPCs were co-stained with rabbit anti-STAT5 and mouse anti-MCM2 antibodies, followed by (E) incubation with respective secondary antibodies, or by (F) proximal ligation assay, which produces amplified signal for labeled molecules in close proximity. (G) CD36+ EPCs were incubated with either DMSO or pimozide (at 30 μM) for 2 days. And then the cells were co-stained with rabbit anti-STAT5 and mouse anti-MCM2 antibodies for proximity ligation assay. (H) Infected EPCs were stained with an anti-capsid antibody. Confocal images were taken with an Eclipse C1 Plus (Nikon) microscope at 100 × magnification. Image collected and cropped by CiteAb from the following open publication (//dx.plos.org/10.1371/journal.ppat.1006370), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/ab-105-c_normal-rabbit-igg-control-822024950325.jpg" title="<b>Biological Strategies Validation. </b>pSTAT5, but not NS1, interacts with the MCM complex.(A) Immunoprecipitation (IP) assay. Cell lysates of NS1Flag-expressing UT7/Epo-S1 cells were prepared for pull-down assays with either anti-Flag-conjugated beads or control beads. Immunoprecipitated proteins were examined for the presence of MCM2 by Western blotting. Blots were reprobed with rabbit anti-pSTAT5(Y694), anti-E2F5, and anti-Flag antibodies. Detection of E2F5 was used as a positive control for NS1 IP. (B) Co-IP assay. UT7/Epo-S1 cells were collected, washed, and lysed with RIPA buffer. After centrifugation, the supernatant was incubated with either rabbit anti-pSTAT5(Y694) or control IgG antibody. Immunoprecipitated proteins were blotted for the presence of the MCM complex with an anti-MCM5 antibody and for pSTAT5 with rabbit anti-pSTAT5(Y694). (C) Reverse Co-IP assay. Reverse Co-IP was performed with an anti-MCM5 antibody. Immunoprecipitated proteins were examined for pSTAT5, MCM2, and MCM5, respectively. (D) Co-IP of lysates treated with DNase. UT7/Epo-S1 cell lysates, either treated or untreated with DNase (750 units of Benzonase) were incubated with anti-pSTAT5(Y694) or control IgG antibodies for Co-IP assay, and immunoprecipitated proteins were examined for MCM2 by Western blot analysis. (E-H) Immunofluorescence analysis. (E&F) Mock- or B19V-infected CD36+ EPCs were co-stained with rabbit anti-STAT5 and mouse anti-MCM2 antibodies, followed by (E) incubation with respective secondary antibodies, or by (F) proximal ligation assay, which produces amplified signal for labeled molecules in close proximity. (G) CD36+ EPCs were incubated with either DMSO or pimozide (at 30 μM) for 2 days. And then the cells were co-stained with rabbit anti-STAT5 and mouse anti-MCM2 antibodies for proximity ligation assay. (H) Infected EPCs were stained with an anti-capsid antibody. Confocal images were taken with an Eclipse C1 Plus (Nikon) microscope at 100 × magnification. Image collected and cropped by CiteAb from the following open publication (//dx.plos.org/10.1371/journal.ppat.1006370), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/ab-105-c_normal-rabbit-igg-control-822024950325.jpg" alt="<b>Biological Strategies Validation. </b>pSTAT5, but not NS1, interacts with the MCM complex.(A) Immunoprecipitation (IP) assay. Cell lysates of NS1Flag-expressing UT7/Epo-S1 cells were prepared for pull-down assays with either anti-Flag-conjugated beads or control beads. Immunoprecipitated proteins were examined for the presence of MCM2 by Western blotting. Blots were reprobed with rabbit anti-pSTAT5(Y694), anti-E2F5, and anti-Flag antibodies. Detection of E2F5 was used as a positive control for NS1 IP. (B) Co-IP assay. UT7/Epo-S1 cells were collected, washed, and lysed with RIPA buffer. After centrifugation, the supernatant was incubated with either rabbit anti-pSTAT5(Y694) or control IgG antibody. Immunoprecipitated proteins were blotted for the presence of the MCM complex with an anti-MCM5 antibody and for pSTAT5 with rabbit anti-pSTAT5(Y694). (C) Reverse Co-IP assay. Reverse Co-IP was performed with an anti-MCM5 antibody. Immunoprecipitated proteins were examined for pSTAT5, MCM2, and MCM5, respectively. (D) Co-IP of lysates treated with DNase. UT7/Epo-S1 cell lysates, either treated or untreated with DNase (750 units of Benzonase) were incubated with anti-pSTAT5(Y694) or control IgG antibodies for Co-IP assay, and immunoprecipitated proteins were examined for MCM2 by Western blot analysis. (E-H) Immunofluorescence analysis. (E&F) Mock- or B19V-infected CD36+ EPCs were co-stained with rabbit anti-STAT5 and mouse anti-MCM2 antibodies, followed by (E) incubation with respective secondary antibodies, or by (F) proximal ligation assay, which produces amplified signal for labeled molecules in close proximity. (G) CD36+ EPCs were incubated with either DMSO or pimozide (at 30 μM) for 2 days. And then the cells were co-stained with rabbit anti-STAT5 and mouse anti-MCM2 antibodies for proximity ligation assay. (H) Infected EPCs were stained with an anti-capsid antibody. Confocal images were taken with an Eclipse C1 Plus (Nikon) microscope at 100 × magnification. Image collected and cropped by CiteAb from the following open publication (//dx.plos.org/10.1371/journal.ppat.1006370), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/ab-105-c_normal-rabbit-igg-control-8220249505941.jpg" title="<b>Biological Strategies Validation. </b>pSTAT5, but not NS1, interacts with the MCM complex.(A) Immunoprecipitation (IP) assay. Cell lysates of NS1Flag-expressing UT7/Epo-S1 cells were prepared for pull-down assays with either anti-Flag-conjugated beads or control beads. Immunoprecipitated proteins were examined for the presence of MCM2 by Western blotting. Blots were reprobed with rabbit anti-pSTAT5(Y694), anti-E2F5, and anti-Flag antibodies. Detection of E2F5 was used as a positive control for NS1 IP. (B) Co-IP assay. UT7/Epo-S1 cells were collected, washed, and lysed with RIPA buffer. After centrifugation, the supernatant was incubated with either rabbit anti-pSTAT5(Y694) or control IgG antibody. Immunoprecipitated proteins were blotted for the presence of the MCM complex with an anti-MCM5 antibody and for pSTAT5 with rabbit anti-pSTAT5(Y694). (C) Reverse Co-IP assay. Reverse Co-IP was performed with an anti-MCM5 antibody. Immunoprecipitated proteins were examined for pSTAT5, MCM2, and MCM5, respectively. (D) Co-IP of lysates treated with DNase. UT7/Epo-S1 cell lysates, either treated or untreated with DNase (750 units of Benzonase) were incubated with anti-pSTAT5(Y694) or control IgG antibodies for Co-IP assay, and immunoprecipitated proteins were examined for MCM2 by Western blot analysis. (E-H) Immunofluorescence analysis. (E&F) Mock- or B19V-infected CD36+ EPCs were co-stained with rabbit anti-STAT5 and mouse anti-MCM2 antibodies, followed by (E) incubation with respective secondary antibodies, or by (F) proximal ligation assay, which produces amplified signal for labeled molecules in close proximity. (G) CD36+ EPCs were incubated with either DMSO or pimozide (at 30 μM) for 2 days. And then the cells were co-stained with rabbit anti-STAT5 and mouse anti-MCM2 antibodies for proximity ligation assay. (H) Infected EPCs were stained with an anti-capsid antibody. Confocal images were taken with an Eclipse C1 Plus (Nikon) microscope at 100 × magnification. Image collected and cropped by CiteAb from the following open publication (//dx.plos.org/10.1371/journal.ppat.1006370), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/ab-105-c_normal-rabbit-igg-control-8220249505941.jpg" alt="<b>Biological Strategies Validation. </b>pSTAT5, but not NS1, interacts with the MCM complex.(A) Immunoprecipitation (IP) assay. Cell lysates of NS1Flag-expressing UT7/Epo-S1 cells were prepared for pull-down assays with either anti-Flag-conjugated beads or control beads. Immunoprecipitated proteins were examined for the presence of MCM2 by Western blotting. Blots were reprobed with rabbit anti-pSTAT5(Y694), anti-E2F5, and anti-Flag antibodies. Detection of E2F5 was used as a positive control for NS1 IP. (B) Co-IP assay. UT7/Epo-S1 cells were collected, washed, and lysed with RIPA buffer. After centrifugation, the supernatant was incubated with either rabbit anti-pSTAT5(Y694) or control IgG antibody. Immunoprecipitated proteins were blotted for the presence of the MCM complex with an anti-MCM5 antibody and for pSTAT5 with rabbit anti-pSTAT5(Y694). (C) Reverse Co-IP assay. Reverse Co-IP was performed with an anti-MCM5 antibody. Immunoprecipitated proteins were examined for pSTAT5, MCM2, and MCM5, respectively. (D) Co-IP of lysates treated with DNase. UT7/Epo-S1 cell lysates, either treated or untreated with DNase (750 units of Benzonase) were incubated with anti-pSTAT5(Y694) or control IgG antibodies for Co-IP assay, and immunoprecipitated proteins were examined for MCM2 by Western blot analysis. (E-H) Immunofluorescence analysis. (E&F) Mock- or B19V-infected CD36+ EPCs were co-stained with rabbit anti-STAT5 and mouse anti-MCM2 antibodies, followed by (E) incubation with respective secondary antibodies, or by (F) proximal ligation assay, which produces amplified signal for labeled molecules in close proximity. (G) CD36+ EPCs were incubated with either DMSO or pimozide (at 30 μM) for 2 days. And then the cells were co-stained with rabbit anti-STAT5 and mouse anti-MCM2 antibodies for proximity ligation assay. (H) Infected EPCs were stained with an anti-capsid antibody. Confocal images were taken with an Eclipse C1 Plus (Nikon) microscope at 100 × magnification. Image collected and cropped by CiteAb from the following open publication (//dx.plos.org/10.1371/journal.ppat.1006370), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/ab-105-c_normal-rabbit-igg-control-22820241721184.jpg" title="Elevated TGF-beta levels in the early inflammatory stage of AS. a Hematoxylin and eosin (H&E) staining and b Safranin O–Fast Green (SOFG) staining of normal and inflamed interspinous ligaments. In the AS group, the right panels show magnified views of the boxed area in the left panels. Scale bar: 100 μm (two panels on the right); 25 μm (left panel). c Immunostaining and d quantitative analysis of CD68-positive cells (brown) in the normal and inflamed interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panels); 25 μm (bottom panels). e Immunostaining and f quantitative analysis of pSmad2/3-positive cells (brown) in the normal and inflamed interspinous ligaments (sagittal view) in normal ligaments and inflammatory ligaments. The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panels); 25 μm (bottom panels). g Immunostaining and h quantitative analysis of pSmad1/5/8-positive cells (brown) in the normal and inflamed interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panels); 25 μm (bottom panels) Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/ab-105-c_normal-rabbit-igg-control-22820241721184.jpg" alt="Elevated TGF-beta levels in the early inflammatory stage of AS. a Hematoxylin and eosin (H&E) staining and b Safranin O–Fast Green (SOFG) staining of normal and inflamed interspinous ligaments. In the AS group, the right panels show magnified views of the boxed area in the left panels. Scale bar: 100 μm (two panels on the right); 25 μm (left panel). c Immunostaining and d quantitative analysis of CD68-positive cells (brown) in the normal and inflamed interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panels); 25 μm (bottom panels). e Immunostaining and f quantitative analysis of pSmad2/3-positive cells (brown) in the normal and inflamed interspinous ligaments (sagittal view) in normal ligaments and inflammatory ligaments. The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panels); 25 μm (bottom panels). g Immunostaining and h quantitative analysis of pSmad1/5/8-positive cells (brown) in the normal and inflamed interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panels); 25 μm (bottom panels) Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/ab-105-c_normal-rabbit-igg-control-22820241723637.jpg" title="Osteoclast resorption of bony interspinous ligaments releases active TGF-beta to drive the progression of ossification in AS patients. e Immunostaining and f quantitative analysis of CD68-positive cells (brown) in the normal and HO-formed interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/ab-105-c_normal-rabbit-igg-control-22820241723637.jpg" alt="Osteoclast resorption of bony interspinous ligaments releases active TGF-beta to drive the progression of ossification in AS patients. e Immunostaining and f quantitative analysis of CD68-positive cells (brown) in the normal and HO-formed interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/ab-105-c_normal-rabbit-igg-control-22820241721149.jpg" title="Chondrocyte differentiation and cartilage formation in interspinous ligaments of AS patients before calcification. a Hematoxylin and eosin (H&E) staining and b Safranin O–Fast Green (SOFG) staining of normal and chondrogenic interspinous ligaments. In the AS group, the right panels show magnified views of the boxed area in the left panels. Scale bar: 100 μm (two panels on the right side); 25 μm (left panel). c Immunostaining and d quantitative analysis of collagen II-positive cells (brown) in the normal and chondrogenic interspinous ligaments (sagittal view). The bottom panels show a magnified view of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). e Immunostaining and f quantitative analysis of pSmad2/3-positive cells (brown) in the normal and chondrogenic interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). g Immunostaining and h quantitative analysis of pSmad1/5/8-positive cells (brown) in the normal and inflammatory interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panels); 25 μm (bottom panels). C, cartilage; L, ligament Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/ab-105-c_normal-rabbit-igg-control-22820241721149.jpg" alt="Chondrocyte differentiation and cartilage formation in interspinous ligaments of AS patients before calcification. a Hematoxylin and eosin (H&E) staining and b Safranin O–Fast Green (SOFG) staining of normal and chondrogenic interspinous ligaments. In the AS group, the right panels show magnified views of the boxed area in the left panels. Scale bar: 100 μm (two panels on the right side); 25 μm (left panel). c Immunostaining and d quantitative analysis of collagen II-positive cells (brown) in the normal and chondrogenic interspinous ligaments (sagittal view). The bottom panels show a magnified view of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). e Immunostaining and f quantitative analysis of pSmad2/3-positive cells (brown) in the normal and chondrogenic interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). g Immunostaining and h quantitative analysis of pSmad1/5/8-positive cells (brown) in the normal and inflammatory interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panels); 25 μm (bottom panels). C, cartilage; L, ligament Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/ab-105-c_normal-rabbit-igg-control-22820241723642.jpg" title="Progression of endochondral heterotopic ossification in AS patients. i Immunostaining and j quantitative analysis of pSmad2/3-positive cells (brown) in the normal ligaments and endochondral-ossified interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). k Immunostaining and l quantitative analysis of Osterix-positive cells (brown) in the normal and endochondral-ossified interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). m Immunostaining and n quantitative analysis of pSmad1/5/8-positive cells (brown) in the normal and inflammatory interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panels); 25 μm (bottom panels). B, bone; BM, bone marrow; C, cartilage Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/ab-105-c_normal-rabbit-igg-control-22820241723642.jpg" alt="Progression of endochondral heterotopic ossification in AS patients. i Immunostaining and j quantitative analysis of pSmad2/3-positive cells (brown) in the normal ligaments and endochondral-ossified interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). k Immunostaining and l quantitative analysis of Osterix-positive cells (brown) in the normal and endochondral-ossified interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). m Immunostaining and n quantitative analysis of pSmad1/5/8-positive cells (brown) in the normal and inflammatory interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panels); 25 μm (bottom panels). B, bone; BM, bone marrow; C, cartilage Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/ab-105-c_normal-rabbit-igg-control-22820241723648.jpg" title="Progression of endochondral heterotopic ossification in AS patients. g Immunostaining and h quantitative analysis of the number of CD68-positive osteoclast (brown) surface (OCS) per bone surface (BS). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). i Immunostaining and j quantitative analysis of pSmad2/3-positive cells (brown) in the normal ligaments and endochondral-ossified interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). k Immunostaining and l quantitative analysis of Osterix-positive cells (brown) in the normal and endochondral-ossified interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). m Immunostaining and n quantitative analysis of pSmad1/5/8-positive cells (brown) in the normal and inflammatory interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panels); 25 μm (bottom panels). B, bone; BM, bone marrow; C, cartilage Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/ab-105-c_normal-rabbit-igg-control-22820241723648.jpg" alt="Progression of endochondral heterotopic ossification in AS patients. g Immunostaining and h quantitative analysis of the number of CD68-positive osteoclast (brown) surface (OCS) per bone surface (BS). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). i Immunostaining and j quantitative analysis of pSmad2/3-positive cells (brown) in the normal ligaments and endochondral-ossified interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). k Immunostaining and l quantitative analysis of Osterix-positive cells (brown) in the normal and endochondral-ossified interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). m Immunostaining and n quantitative analysis of pSmad1/5/8-positive cells (brown) in the normal and inflammatory interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panels); 25 μm (bottom panels). B, bone; BM, bone marrow; C, cartilage Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/ab-105-c_normal-rabbit-igg-control-2282024171534.jpg" title="Chondrocyte differentiation and cartilage formation in interspinous ligaments of AS patients before calcification. a Hematoxylin and eosin (H&E) staining and b Safranin O–Fast Green (SOFG) staining of normal and chondrogenic interspinous ligaments. In the AS group, the right panels show magnified views of the boxed area in the left panels. Scale bar: 100 μm (two panels on the right side); 25 μm (left panel). c Immunostaining and d quantitative analysis of collagen II-positive cells (brown) in the normal and chondrogenic interspinous ligaments (sagittal view). The bottom panels show a magnified view of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). e Immunostaining and f quantitative analysis of pSmad2/3-positive cells (brown) in the normal and chondrogenic interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). g Immunostaining and h quantitative analysis of pSmad1/5/8-positive cells (brown) in the normal and inflammatory interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panels); 25 μm (bottom panels). C, cartilage; L, ligament Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/ab-105-c_normal-rabbit-igg-control-2282024171534.jpg" alt="Chondrocyte differentiation and cartilage formation in interspinous ligaments of AS patients before calcification. a Hematoxylin and eosin (H&E) staining and b Safranin O–Fast Green (SOFG) staining of normal and chondrogenic interspinous ligaments. In the AS group, the right panels show magnified views of the boxed area in the left panels. Scale bar: 100 μm (two panels on the right side); 25 μm (left panel). c Immunostaining and d quantitative analysis of collagen II-positive cells (brown) in the normal and chondrogenic interspinous ligaments (sagittal view). The bottom panels show a magnified view of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). e Immunostaining and f quantitative analysis of pSmad2/3-positive cells (brown) in the normal and chondrogenic interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). g Immunostaining and h quantitative analysis of pSmad1/5/8-positive cells (brown) in the normal and inflammatory interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panels); 25 μm (bottom panels). C, cartilage; L, ligament Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/ab-105-c_normal-rabbit-igg-control-22820241721185.jpg" title="Osteoclast resorption of bony interspinous ligaments releases active TGF-beta to drive the progression of ossification in AS patients. g Immunostaining and h quantitative analysis of pSmad2/3-positive cells in the normal and HO-formed interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). i Immunostaining and j quantitative analysis of Osterix-positive cells (brown) in the normal and HO-formed interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). k Immunostaining and l quantitative analysis of PDGF-BB-positive cells in the normal and HO-formed interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panels); 25 μm (bottom panels). m CD31-positive (red) cells, n EMCN-positive (green) cells and quantification of the fold change of o CD31-positive vessels, p EMCN-positive vessels in the normal and HO-formed interspinous ligaments (sagittal view). q PGP9.5-positive (red) cells and CGRP-positive (green) cells and quantification of the fold change of r PGP9.5 and CGRP double positive nerves in the normal and HO-formed interspinous ligaments (sagittal view). s Immunostaining and t quantitative analysis of pSmad1/5/8-positive cells (brown) in the normal and inflammatory interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panels); 25 μm (bottom panels) Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/ab-105-c_normal-rabbit-igg-control-22820241721185.jpg" alt="Osteoclast resorption of bony interspinous ligaments releases active TGF-beta to drive the progression of ossification in AS patients. g Immunostaining and h quantitative analysis of pSmad2/3-positive cells in the normal and HO-formed interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). i Immunostaining and j quantitative analysis of Osterix-positive cells (brown) in the normal and HO-formed interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panel); 25 μm (bottom panel). k Immunostaining and l quantitative analysis of PDGF-BB-positive cells in the normal and HO-formed interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panels); 25 μm (bottom panels). m CD31-positive (red) cells, n EMCN-positive (green) cells and quantification of the fold change of o CD31-positive vessels, p EMCN-positive vessels in the normal and HO-formed interspinous ligaments (sagittal view). q PGP9.5-positive (red) cells and CGRP-positive (green) cells and quantification of the fold change of r PGP9.5 and CGRP double positive nerves in the normal and HO-formed interspinous ligaments (sagittal view). s Immunostaining and t quantitative analysis of pSmad1/5/8-positive cells (brown) in the normal and inflammatory interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panels); 25 μm (bottom panels) Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/ab-105-c_normal-rabbit-igg-control-22820241721192.jpg" title="Progression of endochondral heterotopic ossification in AS patients. c Immunostaining and d quantitative analysis of collagen II-positive cells (brown) in the normal and chondrogenic interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panels); 25 μm (bottom panels). Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/ab-105-c_normal-rabbit-igg-control-22820241721192.jpg" alt="Progression of endochondral heterotopic ossification in AS patients. c Immunostaining and d quantitative analysis of collagen II-positive cells (brown) in the normal and chondrogenic interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panels); 25 μm (bottom panels). Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/ab-105-c_normal-rabbit-igg-control-22820241721116.jpg" title="Elevated TGF-beta levels in the early inflammatory stage of AS. a Hematoxylin and eosin (H&E) staining and b Safranin O–Fast Green (SOFG) staining of normal and inflamed interspinous ligaments. In the AS group, the right panels show magnified views of the boxed area in the left panels. Scale bar: 100 μm (two panels on the right); 25 μm (left panel). c Immunostaining and d quantitative analysis of CD68-positive cells (brown) in the normal and inflamed interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panels); 25 μm (bottom panels). e Immunostaining and f quantitative analysis of pSmad2/3-positive cells (brown) in the normal and inflamed interspinous ligaments (sagittal view) in normal ligaments and inflammatory ligaments. The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panels); 25 μm (bottom panels). g Immunostaining and h quantitative analysis of pSmad1/5/8-positive cells (brown) in the normal and inflamed interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panels); 25 μm (bottom panels) Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/ab-105-c_normal-rabbit-igg-control-22820241721116.jpg" alt="Elevated TGF-beta levels in the early inflammatory stage of AS. a Hematoxylin and eosin (H&E) staining and b Safranin O–Fast Green (SOFG) staining of normal and inflamed interspinous ligaments. In the AS group, the right panels show magnified views of the boxed area in the left panels. Scale bar: 100 μm (two panels on the right); 25 μm (left panel). c Immunostaining and d quantitative analysis of CD68-positive cells (brown) in the normal and inflamed interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panels); 25 μm (bottom panels). e Immunostaining and f quantitative analysis of pSmad2/3-positive cells (brown) in the normal and inflamed interspinous ligaments (sagittal view) in normal ligaments and inflammatory ligaments. The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panels); 25 μm (bottom panels). g Immunostaining and h quantitative analysis of pSmad1/5/8-positive cells (brown) in the normal and inflamed interspinous ligaments (sagittal view). The bottom panels show magnified views of the boxed area in the top panels. Scale bar: 100 μm (top panels); 25 μm (bottom panels) Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33731675), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div></div><div id="ss_next3" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-3" class="cycle-circle-pager"></div><div id="image-caption-AB-105-C"></div> </div><div class="review_publication_wrapper forcol3"></div> <div class="product-attributes"><div class="field not3column"><label>Reactivity:</label><div class="value"><span title="Rabbit">Rb</span><div class="myModal">Species Glossary</div></div></div><div class="forcol3 bottom_margin"><strong>Reactivity:</strong> <span title="Rabbit">Rb</span></div><div class="field not3column"><label>Applications:</label><div class="value"><span class="application-tooltip-text" title="Control">Ctrl</span></div></div><div class="forcol3 bottom_margin"><strong>Applications:</strong> <span class="application-tooltip-text" title="Control">Ctrl</span></div><div class="field not3column"><label>Host:</label><div class="value">Rabbit Polyclonal</div></div><div class="forcol3 bottom_margin"><strong>Host:</strong> Rabbit Polyclonal</div><div class="field not3column"><label>Conjugate:</label><div class="value">Unconjugated  </div></div><div class="field not3column"><label>Validated by:</label><div class="value">  <span><a href="/5-pillars-validation" class="AtlasBiological" title="Biological Strategies"> </a></span>      </div></div><div class="forcol3 bottom_margin"><strong>Validated by:</strong>   <span><a href="/5-pillars-validation" class="AtlasBiological" title="Biological Strategies"> </a></span>      </div> </div> <div class="compare_block"><input type="checkbox" class="search_compare_checkbox" data-compare='{"Catalog #":"AB-105-C","Product Name":"Normal Rabbit IgG Control","Description":"","Reactivity":"Rabbit","Applications":"Ctrl","Source":"","Purification":"","Immunogen":"NA","Citations":"174","Purity":"","Activity":"","Accession #":"","N-terminal Sequence Analysis":"","Predicated Molecular Mass":"","SDS Page":"","Assay Type":"","Format":"","Assay Length":"","Sample Type and Volume Required":"","Sensitivity":"","Interference":"","Datasheet":"<a href=\"\/products\/igg-isotype-control_ab-105-c\">view datasheet<\/a>","Price":"Price Not Shown"}'><div class="search_compare">compare</div> <div class="search_compare_text">(select up to 3 products from this page to compare)</div> </div> <div class="clear"></div> </div><div class="new-search-result search-result-wrapper" > <div class="name"><span> <div class="catalog_number_wrapper not3column"> <a href="/products/igg2b-isotype-control-20116_mab004">MAB004</a> </div><h2 class="col3_hdr"><a data-brand="rnd" data-id="MAB004" data-name="Mouse IgG2b Isotype Control (20116) [Unconjugated]" data-position="5" class="ecommerce_link" href="/products/igg2b-isotype-control-20116_mab004" title="Mouse IgG2b Isotype Control (20116) [Unconjugated]" ><span> Mouse IgG2b Isotype Control (20116) [Unconjugated]</span></a></div></h2> <div class="sub-header"> <div class="flourish_left"></div> <div class="flourish_right"></div><div class="prod_details_section"> <div class="segment"> <a title="2 Reviews for this product" href="/products/igg2b-isotype-control-20116_mab004#ReviewsSection"><span class="stars5"></span> (2 Reviews)</a> </div> <div class="segment"> <a title="101 Publications specific to this product" href="/products/igg2b-isotype-control-20116_mab004#PublicationSection"><span class="publications"></span> (101 Publications)</a> </div> <div class="segment" style="float:right;"> <strong>500 μg</strong><span class="product_price" data-sku="MAB004"></span> </div> </div> </div> <div class="images"> <div class="catalog_number_wrapper_col3 forcol3"> <a href="/products/igg2b-isotype-control-20116_mab004">MAB004</a> </div><div class="cycle-slideshow slideshows" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-4" data-cycle-prev="#ss_prev4" data-cycle-next="#ss_next4" data-cycle-caption="#image-caption-MAB004" data-cycle-caption-template="Image {{slideNum}} / {{slideCount}}" data-cycle-slides=".big_thumb_container" ><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize2/IgG2B_MAB004_Control_19430.jpg" title="K562 human chronic myelogenous leukemia cell line wasstained with Mouse Anti-Human ITFG1 Monoclonal Antibody (Catalog #MAB89001,filled histogram) or Mouse IgG Isotype Control Antibody (Catalog #MAB004,open histogram), followed by Allophycocyanin-conjugated Anti-Mouse IgGSecondary Antibody (Catalog # F0101B)." class="big_lightbox"> <img src="//images.novusbio.com/images2/IgG2B_MAB004_Control_19430.jpg" title="K562 human chronic myelogenous leukemia cell line wasstained with Mouse Anti-Human ITFG1 Monoclonal Antibody (Catalog #MAB89001,filled histogram) or Mouse IgG Isotype Control Antibody (Catalog #MAB004,open histogram), followed by Allophycocyanin-conjugated Anti-Mouse IgGSecondary Antibody (Catalog # F0101B)." alt="K562 human chronic myelogenous leukemia cell line wasstained with Mouse Anti-Human ITFG1 Monoclonal Antibody (Catalog #MAB89001,filled histogram) or Mouse IgG Isotype Control Antibody (Catalog #MAB004,open histogram), followed by Allophycocyanin-conjugated Anti-Mouse IgGSecondary Antibody (Catalog # F0101B)." class="big_thumb" /> </a> </div></div><div class="pager_fill"></div><div id="image-caption-MAB004"></div> </div><div class="review_publication_wrapper forcol3"></div> <div class="product-attributes"><div class="field not3column"><label>Reactivity:</label><div class="value"><span title="Mouse">Mu</span><div class="myModal">Species Glossary</div></div></div><div class="forcol3 bottom_margin"><strong>Reactivity:</strong> <span title="Mouse">Mu</span></div><div class="field not3column"><label>Applications:</label><div class="value"><span class="application-tooltip-text" title="Control">Ctrl</span></div></div><div class="forcol3 bottom_margin"><strong>Applications:</strong> <span class="application-tooltip-text" title="Control">Ctrl</span></div><div class="field not3column"><label>Host:</label><div class="value">Mouse Monoclonal</div></div><div class="forcol3 bottom_margin"><strong>Host:</strong> Mouse Monoclonal</div><div class="field not3column"><label>Conjugate:</label><div class="value">Unconjugated  </div></div> </div> <div class="compare_block"><input type="checkbox" class="search_compare_checkbox" data-compare='{"Catalog #":"MAB004","Product Name":"Mouse IgG2B Isotype Control","Description":"","Reactivity":"Mouse","Applications":"Ctrl","Source":"","Purification":"","Immunogen":"KLH","Citations":"101","Purity":"","Activity":"","Accession #":"","N-terminal Sequence Analysis":"","Predicated Molecular Mass":"","SDS Page":"","Assay Type":"","Format":"","Assay Length":"","Sample Type and Volume Required":"","Sensitivity":"","Interference":"","Datasheet":"<a href=\"\/products\/igg2b-isotype-control-20116_mab004\">view datasheet<\/a>","Price":"Price Not Shown"}'><div class="search_compare">compare</div> <div class="search_compare_text">(select up to 3 products from this page to compare)</div> </div> <div class="clear"></div> </div><div class="new-search-result search-result-wrapper" > <div class="name"><span> <div class="catalog_number_wrapper not3column"> <a href="/products/igg2a-isotype-control-20102_mab003">MAB003</a> </div><h2 class="col3_hdr"><a data-brand="rnd" data-id="MAB003" data-name="Mouse IgG2a Isotype Control (20102) [Unconjugated]" data-position="6" class="ecommerce_link" href="/products/igg2a-isotype-control-20102_mab003" title="Mouse IgG2a Isotype Control (20102) [Unconjugated]" ><span> Mouse IgG2a Isotype Control (20102) [Unconjugated]</span></a></div></h2> <div class="sub-header"> <div class="flourish_left"></div> <div class="flourish_right"></div><div class="prod_details_section"> <div class="segment"> <a title="1 Review for this product" href="/products/igg2a-isotype-control-20102_mab003#ReviewsSection"><span class="stars5"></span> (1 Review)</a> </div> <div class="segment"> <a title="97 Publications specific to this product" href="/products/igg2a-isotype-control-20102_mab003#PublicationSection"><span class="publications"></span> (97 Publications)</a> </div> <div class="segment" style="float:right;"> <strong>500 μg</strong><span class="product_price" data-sku="MAB003"></span> </div> </div> </div> <div class="images"> <div class="catalog_number_wrapper_col3 forcol3"> <a href="/products/igg2a-isotype-control-20102_mab003">MAB003</a> </div><div id="ss_prev5" class="cycle-pager"><div class="pager_left_on"></div></div><div class="cycle-slideshow slideshows" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-5" data-cycle-prev="#ss_prev5" data-cycle-next="#ss_next5" data-cycle-caption="#image-caption-MAB003" data-cycle-caption-template="Image {{slideNum}} / {{slideCount}}" data-cycle-slides=".big_thumb_container" ><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize2/IgG2A_MAB003_Control_19426.jpg" title="Human peripheral blood granulocytes were stained with MouseAnti-HumanCXCR1/IL-8 RA Monoclonal Antibody (Catalog # MAB330,filled histogram) or Mouse IgG Isotype Control Antibody (Catalog # MAB003,open histogram), followed by Phycoerythrin-conjugated Anti-Mouse IgG SecondaryAntibody (Catalog # F0102B)." class="big_lightbox"> <img src="//images.novusbio.com/images2/IgG2A_MAB003_Control_19426.jpg" title="Human peripheral blood granulocytes were stained with MouseAnti-HumanCXCR1/IL-8 RA Monoclonal Antibody (Catalog # MAB330,filled histogram) or Mouse IgG Isotype Control Antibody (Catalog # MAB003,open histogram), followed by Phycoerythrin-conjugated Anti-Mouse IgG SecondaryAntibody (Catalog # F0102B)." alt="Human peripheral blood granulocytes were stained with MouseAnti-HumanCXCR1/IL-8 RA Monoclonal Antibody (Catalog # MAB330,filled histogram) or Mouse IgG Isotype Control Antibody (Catalog # MAB003,open histogram), followed by Phycoerythrin-conjugated Anti-Mouse IgG SecondaryAntibody (Catalog # F0102B)." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/mab003_mouse-igg2a-isotype-control-clone-20102-41202412512667.jpg" title="Transmammary transfer of BMP9 and BMP10 blocking Abs leads to abnormal hypervascularization in neonatal retinas.(A–C”) Representative images of fluorescent isolectin B4-stained retinas either from P6 neonates fed for 3 days by dams injected on P3 with PBS (A), control IgG2a/b Abs (B), or BMP9/10 blocking Abs (C–C”). (C’,C”) are higher magnification images of the relevant boxed areas in C. a, artery; v, vein; scale bars, 500 μm. (D–L) Higher magnification showing retinal vasculature fields between an artery and a vein (Plexus, D–F), or at the front of an artery (G–I) or a vein (J–L) from neonates treated as in (A–C). Scale bars, 100 μm. (M–O) Scatter plots showing the vascular density on retinal ‘petals’ at the plexus (M), artery front (N), or vein front (O). Data represent mean ± s.e.m. (n = 6 pups per group from 2 dams); ****P < 0.0001, ANOVA and Kruskal-Wallis test. Arrows indicate AVMs, defined as direct shunts between an artery and a vein. Image collected and cropped by CiteAb from the following publication (//www.nature.com/articles/srep37366), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/mab003_mouse-igg2a-isotype-control-clone-20102-41202412512667.jpg" alt="Transmammary transfer of BMP9 and BMP10 blocking Abs leads to abnormal hypervascularization in neonatal retinas.(A–C”) Representative images of fluorescent isolectin B4-stained retinas either from P6 neonates fed for 3 days by dams injected on P3 with PBS (A), control IgG2a/b Abs (B), or BMP9/10 blocking Abs (C–C”). (C’,C”) are higher magnification images of the relevant boxed areas in C. a, artery; v, vein; scale bars, 500 μm. (D–L) Higher magnification showing retinal vasculature fields between an artery and a vein (Plexus, D–F), or at the front of an artery (G–I) or a vein (J–L) from neonates treated as in (A–C). Scale bars, 100 μm. (M–O) Scatter plots showing the vascular density on retinal ‘petals’ at the plexus (M), artery front (N), or vein front (O). Data represent mean ± s.e.m. (n = 6 pups per group from 2 dams); ****P < 0.0001, ANOVA and Kruskal-Wallis test. Arrows indicate AVMs, defined as direct shunts between an artery and a vein. Image collected and cropped by CiteAb from the following publication (//www.nature.com/articles/srep37366), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div></div><div id="ss_next5" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-5" class="cycle-circle-pager"></div><div id="image-caption-MAB003"></div> </div><div class="review_publication_wrapper forcol3"></div> <div class="product-attributes"><div class="field not3column"><label>Reactivity:</label><div class="value"><span title="Mouse">Mu</span><div class="myModal">Species Glossary</div></div></div><div class="forcol3 bottom_margin"><strong>Reactivity:</strong> <span title="Mouse">Mu</span></div><div class="field not3column"><label>Applications:</label><div class="value"><span class="application-tooltip-text" title="Control">Ctrl</span></div></div><div class="forcol3 bottom_margin"><strong>Applications:</strong> <span class="application-tooltip-text" title="Control">Ctrl</span></div><div class="field not3column"><label>Host:</label><div class="value">Mouse Monoclonal</div></div><div class="forcol3 bottom_margin"><strong>Host:</strong> Mouse Monoclonal</div><div class="field not3column"><label>Conjugate:</label><div class="value">Unconjugated  <div class="list_expand not3column options_closed" data-name="Conjugates" data-wrapper-type=".conjugates_wrapper">Available Conjugates: <div class="expander option_closed"></div></div></div></div> </div><div class="forcol3 option_buttons_block"><button class="options_button" data-type="conjugates">Conjugates</button></div><div class="conjugates_wrapper" data-title="Mouse IgG2a Isotype Control (20102) [Unconjugated]" data-catnum="MAB003"><table class="scf_table"> <thead> <tr> <th>Conjugate</th> <th>Catalog #</th> <th class="head_avail">Availability</th> <th>Size</th> <th class="col_price">Price</th> </tr> </thead> <tbody><tr class="popup_sku" data-sku="IC003V"> <td><a href="/products/igg2a-isotype-control-20102_ic003v">Alexa Fluor 405</a></td> <td><a href="/products/igg2a-isotype-control-20102_ic003v">IC003V</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC003G"> <td><a href="/products/igg2a-isotype-control-20102_ic003g">Alexa Fluor 488</a></td> <td><a href="/products/igg2a-isotype-control-20102_ic003g">IC003G</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC003T"> <td><a href="/products/igg2a-isotype-control-20102_ic003t">Alexa Fluor 594</a></td> <td><a href="/products/igg2a-isotype-control-20102_ic003t">IC003T</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC003R"> <td><a href="/products/igg2a-isotype-control-20102_ic003r">Alexa Fluor 647</a></td> <td><a href="/products/igg2a-isotype-control-20102_ic003r">IC003R</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC003N"> <td><a href="/products/igg2a-isotype-control-20102_ic003n">Alexa Fluor 700</a></td> <td><a href="/products/igg2a-isotype-control-20102_ic003n">IC003N</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC003S"> <td><a href="/products/igg2a-isotype-control-20102_ic003s">Alexa Fluor 750</a></td> <td><a href="/products/igg2a-isotype-control-20102_ic003s">IC003S</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC003A"> <td><a href="/products/igg2a-isotype-control-20102_ic003a">Allophycocyanin</a></td> <td><a href="/products/igg2a-isotype-control-20102_ic003a">IC003A</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC003B"> <td><a href="/products/igg2a-isotype-control-20102_ic003b">Biotin</a></td> <td><a href="/products/igg2a-isotype-control-20102_ic003b">IC003B</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC003F"> <td><a href="/products/igg2a-isotype-control-20102_ic003f">Fluorescein</a></td> <td><a href="/products/igg2a-isotype-control-20102_ic003f">IC003F</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC003C"> <td><a href="/products/igg2a-isotype-control-20102_ic003c">PerCP (Peridinin-chlorophyll Protein Complex)</a></td> <td><a href="/products/igg2a-isotype-control-20102_ic003c">IC003C</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC003P"> <td><a href="/products/igg2a-isotype-control-20102_ic003p">Phycoerythrin</a></td> <td><a href="/products/igg2a-isotype-control-20102_ic003p">IC003P</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr> <tr class="scf_footer"> <td colspan="5"><div class="expander option_opened"></div></td> </tr> </tbody> </table> <div class="popup_skus" data-skus='["IC003V","IC003G","IC003T","IC003R","IC003N","IC003S","IC003A","IC003B","IC003F","IC003C","IC003P"]' data-rendered="false"></div></div><div class="product-attributes" style="margin-top:-10px;padding-top:0px;"><div class="field not3column"><label>&nbsp</label><div class="value"><div class="list_expand not3column options_closed" data-name="Formulations" data-wrapper-type=".formulations_wrapper" style="margin-left:0px;">Available Formulations <div class="expander option_closed"></div></div></div></div></div><div class="forcol3 option_buttons_block"><button class="options_button" data-type="formulations">Formulations</button></div><div class="formulations_wrapper" data-title="Mouse IgG2a Isotype Control (20102) [Unconjugated]" data-catnum="MAB003"><table class="scf_table"> <thead> <tr> <th>Formulation</th> <th>Catalog #</th> <th>Availability</th> <th>Price</th> <th> </th> </tr> </thead> <tbody><tr class="popup_sku" data-sku="IC003A"> <td><a href="/products/igg2a-isotype-control-20102_ic003a">Carrier Free</a></td> <td><a href="/products/igg2a-isotype-control-20102_ic003a">IC003A</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/416160"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC003B"> <td><a href="/products/igg2a-isotype-control-20102_ic003b">Carrier Free</a></td> <td><a href="/products/igg2a-isotype-control-20102_ic003b">IC003B</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/416161"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC003C"> <td><a href="/products/igg2a-isotype-control-20102_ic003c">Carrier Free</a></td> <td><a href="/products/igg2a-isotype-control-20102_ic003c">IC003C</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/416162"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC003F"> <td><a href="/products/igg2a-isotype-control-20102_ic003f">Carrier Free</a></td> <td><a href="/products/igg2a-isotype-control-20102_ic003f">IC003F</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/416163"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC003G"> <td><a href="/products/igg2a-isotype-control-20102_ic003g">Carrier Free</a></td> <td><a href="/products/igg2a-isotype-control-20102_ic003g">IC003G</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/416164"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC003N"> <td><a href="/products/igg2a-isotype-control-20102_ic003n">Carrier Free</a></td> <td><a href="/products/igg2a-isotype-control-20102_ic003n">IC003N</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/416165"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC003P"> <td><a href="/products/igg2a-isotype-control-20102_ic003p">Carrier Free</a></td> <td><a href="/products/igg2a-isotype-control-20102_ic003p">IC003P</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/416166"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC003S"> <td><a href="/products/igg2a-isotype-control-20102_ic003s">Carrier Free</a></td> <td><a href="/products/igg2a-isotype-control-20102_ic003s">IC003S</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/449120"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC003T"> <td><a href="/products/igg2a-isotype-control-20102_ic003t">Carrier Free</a></td> <td><a href="/products/igg2a-isotype-control-20102_ic003t">IC003T</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/449129"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC003R"> <td><a href="/products/igg2a-isotype-control-20102_ic003r">Carrier Free</a></td> <td><a href="/products/igg2a-isotype-control-20102_ic003r">IC003R</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/449139"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC003V"> <td><a href="/products/igg2a-isotype-control-20102_ic003v">Carrier Free</a></td> <td><a href="/products/igg2a-isotype-control-20102_ic003v">IC003V</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/449152"><div class="purchase_cart"></div></a></td> </tr> <tr class="scf_footer"> <td colspan="5"><div class="expander option_opened"></div></td> </tr> </tbody> </table> <div class="popup_skus" data-skus='["IC003A","IC003B","IC003C","IC003F","IC003G","IC003N","IC003P","IC003S","IC003T","IC003R","IC003V"]' data-rendered="false"></div></div> <div class="compare_block"><input type="checkbox" class="search_compare_checkbox" data-compare='{"Catalog #":"MAB003","Product Name":"Mouse IgG2A Isotype Control","Description":"","Reactivity":"Mouse","Applications":"Ctrl","Source":"","Purification":"","Immunogen":"KLH","Citations":"97","Purity":"","Activity":"","Accession #":"","N-terminal Sequence Analysis":"","Predicated Molecular Mass":"","SDS Page":"","Assay Type":"","Format":"","Assay Length":"","Sample Type and Volume Required":"","Sensitivity":"","Interference":"","Datasheet":"<a href=\"\/products\/igg2a-isotype-control-20102_mab003\">view datasheet<\/a>","Price":"Price Not Shown"}'><div class="search_compare">compare</div> <div class="search_compare_text">(select up to 3 products from this page to compare)</div> </div> <div class="clear"></div> </div><div class="new-search-result search-result-wrapper" > <div class="name"><span> <div class="catalog_number_wrapper not3column"> <a href="/products/igg1-isotype-control-43414_mab005">MAB005</a> </div><h2 class="col3_hdr"><a data-brand="rnd" data-id="MAB005" data-name="Rat IgG1 Isotype Control (43414) [Unconjugated]" data-position="7" class="ecommerce_link" href="/products/igg1-isotype-control-43414_mab005" title="Rat IgG1 Isotype Control (43414) [Unconjugated]" ><span> Rat IgG1 Isotype Control (43414) [Unconjugated]</span></a></div></h2> <div class="sub-header"> <div class="flourish_left"></div> <div class="flourish_right"></div><div class="prod_details_section"> <div class="segment"> <a title="1 Review for this product" href="/products/igg1-isotype-control-43414_mab005#ReviewsSection"><span class="stars5"></span> (1 Review)</a> </div> <div class="segment"> <a title="83 Publications specific to this product" href="/products/igg1-isotype-control-43414_mab005#PublicationSection"><span class="publications"></span> (83 Publications)</a> </div> <div class="segment" style="float:right;"> <strong>500 μg</strong><span class="product_price" data-sku="MAB005"></span> </div> </div> </div> <div class="images"> <div class="catalog_number_wrapper_col3 forcol3"> <a href="/products/igg1-isotype-control-43414_mab005">MAB005</a> </div><div class="cycle-slideshow slideshows" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-6" data-cycle-prev="#ss_prev6" data-cycle-next="#ss_next6" data-cycle-caption="#image-caption-MAB005" data-cycle-caption-template="Image {{slideNum}} / {{slideCount}}" data-cycle-slides=".big_thumb_container" ><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize2/IgG1_MAB005_Control_19431.jpg" title="Mouse platelets were stained with Rat Anti-Mouse GPVIMonoclonal Antibody (Catalog # MAB6758,filled histogram) or Rat IgG Isotype Control Antibody (Catalog # MAB005,open histogram), followed by Allophycocyanin-conjugated Anti-Rat IgG SecondaryAntibody (Catalog # F0113)." class="big_lightbox"> <img src="//images.novusbio.com/images2/IgG1_MAB005_Control_19431.jpg" title="Mouse platelets were stained with Rat Anti-Mouse GPVIMonoclonal Antibody (Catalog # MAB6758,filled histogram) or Rat IgG Isotype Control Antibody (Catalog # MAB005,open histogram), followed by Allophycocyanin-conjugated Anti-Rat IgG SecondaryAntibody (Catalog # F0113)." alt="Mouse platelets were stained with Rat Anti-Mouse GPVIMonoclonal Antibody (Catalog # MAB6758,filled histogram) or Rat IgG Isotype Control Antibody (Catalog # MAB005,open histogram), followed by Allophycocyanin-conjugated Anti-Rat IgG SecondaryAntibody (Catalog # F0113)." class="big_thumb" /> </a> </div></div><div class="pager_fill"></div><div id="image-caption-MAB005"></div> </div><div class="review_publication_wrapper forcol3"></div> <div class="product-attributes"><div class="field not3column"><label>Reactivity:</label><div class="value"><span title="Rat">Rt</span><div class="myModal">Species Glossary</div></div></div><div class="forcol3 bottom_margin"><strong>Reactivity:</strong> <span title="Rat">Rt</span></div><div class="field not3column"><label>Applications:</label><div class="value"><span class="application-tooltip-text" title="Control">Ctrl</span></div></div><div class="forcol3 bottom_margin"><strong>Applications:</strong> <span class="application-tooltip-text" title="Control">Ctrl</span></div><div class="field not3column"><label>Host:</label><div class="value">Rat Monoclonal</div></div><div class="forcol3 bottom_margin"><strong>Host:</strong> Rat Monoclonal</div><div class="field not3column"><label>Conjugate:</label><div class="value">Unconjugated  <div class="list_expand not3column options_closed" data-name="Conjugates" data-wrapper-type=".conjugates_wrapper">Available Conjugates: <div class="expander option_closed"></div></div></div></div> </div><div class="forcol3 option_buttons_block"><button class="options_button" data-type="conjugates">Conjugates</button></div><div class="conjugates_wrapper" data-title="Rat IgG1 Isotype Control (43414) [Unconjugated]" data-catnum="MAB005"><table class="scf_table"> <thead> <tr> <th>Conjugate</th> <th>Catalog #</th> <th class="head_avail">Availability</th> <th>Size</th> <th class="col_price">Price</th> </tr> </thead> <tbody><tr class="popup_sku" data-sku="IC005V"> <td><a href="/products/igg1-isotype-control-43414_ic005v">Alexa Fluor 405</a></td> <td><a href="/products/igg1-isotype-control-43414_ic005v">IC005V</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC005G"> <td><a href="/products/igg1-isotype-control-43414_ic005g">Alexa Fluor 488</a></td> <td><a href="/products/igg1-isotype-control-43414_ic005g">IC005G</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC005T"> <td><a href="/products/igg1-isotype-control-43414_ic005t">Alexa Fluor 594</a></td> <td><a href="/products/igg1-isotype-control-43414_ic005t">IC005T</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC005R"> <td><a href="/products/igg1-isotype-control-43414_ic005r">Alexa Fluor 647</a></td> <td><a href="/products/igg1-isotype-control-43414_ic005r">IC005R</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC005N"> <td><a href="/products/igg1-isotype-control-43414_ic005n">Alexa Fluor 700</a></td> <td><a href="/products/igg1-isotype-control-43414_ic005n">IC005N</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC005S"> <td><a href="/products/igg1-isotype-control-43414_ic005s">Alexa Fluor 750</a></td> <td><a href="/products/igg1-isotype-control-43414_ic005s">IC005S</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC005A"> <td><a href="/products/igg1-isotype-control-43414_ic005a">Allophycocyanin</a></td> <td><a href="/products/igg1-isotype-control-43414_ic005a">IC005A</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC005F"> <td><a href="/products/igg1-isotype-control-43414_ic005f">Fluorescein</a></td> <td><a href="/products/igg1-isotype-control-43414_ic005f">IC005F</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC005P"> <td><a href="/products/igg1-isotype-control-43414_ic005p">Phycoerythrin</a></td> <td><a href="/products/igg1-isotype-control-43414_ic005p">IC005P</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr> <tr class="scf_footer"> <td colspan="5"><div class="expander option_opened"></div></td> </tr> </tbody> </table> <div class="popup_skus" data-skus='["IC005V","IC005G","IC005T","IC005R","IC005N","IC005S","IC005A","IC005F","IC005P"]' data-rendered="false"></div></div><div class="product-attributes" style="margin-top:-10px;padding-top:0px;"><div class="field not3column"><label>&nbsp</label><div class="value"><div class="list_expand not3column options_closed" data-name="Formulations" data-wrapper-type=".formulations_wrapper" style="margin-left:0px;">Available Formulations <div class="expander option_closed"></div></div></div></div></div><div class="forcol3 option_buttons_block"><button class="options_button" data-type="formulations">Formulations</button></div><div class="formulations_wrapper" data-title="Rat IgG1 Isotype Control (43414) [Unconjugated]" data-catnum="MAB005"><table class="scf_table"> <thead> <tr> <th>Formulation</th> <th>Catalog #</th> <th>Availability</th> <th>Price</th> <th> </th> </tr> </thead> <tbody><tr class="popup_sku" data-sku="IC005A"> <td><a href="/products/igg1-isotype-control-43414_ic005a">Carrier Free</a></td> <td><a href="/products/igg1-isotype-control-43414_ic005a">IC005A</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/416174"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC005F"> <td><a href="/products/igg1-isotype-control-43414_ic005f">Carrier Free</a></td> <td><a href="/products/igg1-isotype-control-43414_ic005f">IC005F</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/416177"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC005G"> <td><a href="/products/igg1-isotype-control-43414_ic005g">Carrier Free</a></td> <td><a href="/products/igg1-isotype-control-43414_ic005g">IC005G</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/416178"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC005N"> <td><a href="/products/igg1-isotype-control-43414_ic005n">Carrier Free</a></td> <td><a href="/products/igg1-isotype-control-43414_ic005n">IC005N</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/416179"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC005P"> <td><a href="/products/igg1-isotype-control-43414_ic005p">Carrier Free</a></td> <td><a href="/products/igg1-isotype-control-43414_ic005p">IC005P</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/416180"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC005R"> <td><a href="/products/igg1-isotype-control-43414_ic005r">Carrier Free</a></td> <td><a href="/products/igg1-isotype-control-43414_ic005r">IC005R</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/472779"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC005S"> <td><a href="/products/igg1-isotype-control-43414_ic005s">Carrier Free</a></td> <td><a href="/products/igg1-isotype-control-43414_ic005s">IC005S</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/473281"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC005T"> <td><a href="/products/igg1-isotype-control-43414_ic005t">Carrier Free</a></td> <td><a href="/products/igg1-isotype-control-43414_ic005t">IC005T</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/473282"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC005V"> <td><a href="/products/igg1-isotype-control-43414_ic005v">Carrier Free</a></td> <td><a href="/products/igg1-isotype-control-43414_ic005v">IC005V</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/490186"><div class="purchase_cart"></div></a></td> </tr> <tr class="scf_footer"> <td colspan="5"><div class="expander option_opened"></div></td> </tr> </tbody> </table> <div class="popup_skus" data-skus='["IC005A","IC005F","IC005G","IC005N","IC005P","IC005R","IC005S","IC005T","IC005V"]' data-rendered="false"></div></div> <div class="compare_block"><input type="checkbox" class="search_compare_checkbox" data-compare='{"Catalog #":"MAB005","Product Name":"Rat IgG1 Isotype Control","Description":"","Reactivity":"Rat","Applications":"Ctrl","Source":"","Purification":"","Immunogen":"KLH","Citations":"83","Purity":"","Activity":"","Accession #":"","N-terminal Sequence Analysis":"","Predicated Molecular Mass":"","SDS Page":"","Assay Type":"","Format":"","Assay Length":"","Sample Type and Volume Required":"","Sensitivity":"","Interference":"","Datasheet":"<a href=\"\/products\/igg1-isotype-control-43414_mab005\">view datasheet<\/a>","Price":"Price Not Shown"}'><div class="search_compare">compare</div> <div class="search_compare_text">(select up to 3 products from this page to compare)</div> </div> <div class="clear"></div> </div><div class="new-search-result search-result-wrapper" > <div class="name"><span> <div class="catalog_number_wrapper not3column"> <a href="/products/igg-isotype-control_nbp2-24891">NBP2-24891</a> </div><h2 class="col3_hdr"><a data-brand="novus" data-id="NBP2-24891" data-name="Rabbit IgG Isotype Control" data-position="8" class="ecommerce_link" href="/products/igg-isotype-control_nbp2-24891" title="Rabbit IgG Isotype Control" ><span> Rabbit IgG Isotype Control</span></a></div></h2> <div class="sub-header"> <div class="flourish_left"></div> <div class="flourish_right"></div><div class="prod_details_section"> <div class="segment"> <a title="1 Review for this product" href="/products/igg-isotype-control_nbp2-24891#ReviewsSection"><span class="stars5"></span> (1 Review)</a> </div> <div class="segment"> <a title="55 Publications specific to this product" href="/products/igg-isotype-control_nbp2-24891#PublicationSection"><span class="publications"></span> (55 Publications)</a> </div> <div class="segment" style="float:right;"> <strong>0.1 mg</strong><span class="product_price" data-sku="NBP2-24891"></span> </div> </div> </div> <div class="images"> <div class="catalog_number_wrapper_col3 forcol3"> <a href="/products/igg-isotype-control_nbp2-24891">NBP2-24891</a> </div><div id="ss_prev7" class="cycle-pager"><div class="pager_left_on"></div></div><div class="cycle-slideshow slideshows" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-7" data-cycle-prev="#ss_prev7" data-cycle-next="#ss_next7" data-cycle-caption="#image-caption-NBP2-24891" data-cycle-caption-template="Image {{slideNum}} / {{slideCount}}" data-cycle-slides=".big_thumb_container" ><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/Rabbit--Mouse-IgG-Isotype-Control-Immunohistochemistry-NBP2-24891-img0007.jpg" title="Immunohistochemistry: Rabbit IgG Isotype Control [NBP2-24891] - Controls for alpha-MSH immunohistochemistry and immunofluorescence. (A) Isotype controls for alpha-MSH were obtained by staining consecutive sections of human and mouse atherosclerotic plaques with alpha-MSH antibody or rabbit polyclonal isotype control antibody. Image collected and cropped by CiteAb from the following publication (//www.nature.com/articles/s41598-018-33523-7) licensed under a CC-BY license." class="big_lightbox"> <img src="//images.novusbio.com/images/Rabbit--Mouse-IgG-Isotype-Control-Immunohistochemistry-NBP2-24891-img0007.jpg" title="Immunohistochemistry: Rabbit IgG Isotype Control [NBP2-24891] - Controls for alpha-MSH immunohistochemistry and immunofluorescence. (A) Isotype controls for alpha-MSH were obtained by staining consecutive sections of human and mouse atherosclerotic plaques with alpha-MSH antibody or rabbit polyclonal isotype control antibody. Image collected and cropped by CiteAb from the following publication (//www.nature.com/articles/s41598-018-33523-7) licensed under a CC-BY license." alt="Immunohistochemistry: Rabbit IgG Isotype Control [NBP2-24891] - Controls for alpha-MSH immunohistochemistry and immunofluorescence. (A) Isotype controls for alpha-MSH were obtained by staining consecutive sections of human and mouse atherosclerotic plaques with alpha-MSH antibody or rabbit polyclonal isotype control antibody. Image collected and cropped by CiteAb from the following publication (//www.nature.com/articles/s41598-018-33523-7) licensed under a CC-BY license." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/Rabbit--Mouse-IgG-Isotype-Control-Flow-Cytometry-NBP2-24891-img0006.jpg" title="Flow Cytometry: Rabbit IgG Isotype Control [NBP2-24891] - An intracellular stain was performed on Raji cells with Adiponectin antibody NB100-65810 (blue) and a matched isotype control NBP2-24893 (orange). Cells were fixed with 4% PFA and then permeablized with 0.1% saponin. Cells were incubated in an antibody dilution of 1 ug/mL for 30 minutes at room temperature, followed by Dylight488-conjugated anti-rabbit secondary antibody. Image using the Azide Free form of this antibody." class="big_lightbox"> <img src="//images.novusbio.com/images/Rabbit--Mouse-IgG-Isotype-Control-Flow-Cytometry-NBP2-24891-img0006.jpg" alt="Flow Cytometry: Rabbit IgG Isotype Control [NBP2-24891] - An intracellular stain was performed on Raji cells with Adiponectin antibody NB100-65810 (blue) and a matched isotype control NBP2-24893 (orange). Cells were fixed with 4% PFA and then permeablized with 0.1% saponin. Cells were incubated in an antibody dilution of 1 ug/mL for 30 minutes at room temperature, followed by Dylight488-conjugated anti-rabbit secondary antibody. Image using the Azide Free form of this antibody." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/Rabbit--Mouse-IgG-Isotype-Control-Flow-Cytometry-NBP2-24891-img0001.jpg" title="Flow Cytometry: Rabbit IgG Isotype Control [NBP2-24891] - Intracellular FACS analysis of mouse TLR6 polyclonal antibody (red), rabbit isotype control (green), RAW cells alone (shaded). Two micrograms of antibodies were used. Goat anti-rabbit FITC (Novus, 20302) was used as secondary." class="big_lightbox"> <img src="//images.novusbio.com/images/Rabbit--Mouse-IgG-Isotype-Control-Flow-Cytometry-NBP2-24891-img0001.jpg" alt="Flow Cytometry: Rabbit IgG Isotype Control [NBP2-24891] - Intracellular FACS analysis of mouse TLR6 polyclonal antibody (red), rabbit isotype control (green), RAW cells alone (shaded). Two micrograms of antibodies were used. Goat anti-rabbit FITC (Novus, 20302) was used as secondary." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/Rabbit--Mouse-IgG-Isotype-Control-Flow-Cytometry-NBP2-24891-img0002.jpg" title="Flow Cytometry: Rabbit IgG Isotype Control [NBP2-24891] - PBMCs fixed and permeabilized using the Novus intracellular staining kit and stained with 1 ug of TLR7-PE conjugate (red) or rabbit IgG-PE conjugate isotype control (NBP2-24983, green). Image using the PE form of this antibody." class="big_lightbox"> <img src="//images.novusbio.com/images/Rabbit--Mouse-IgG-Isotype-Control-Flow-Cytometry-NBP2-24891-img0002.jpg" alt="Flow Cytometry: Rabbit IgG Isotype Control [NBP2-24891] - PBMCs fixed and permeabilized using the Novus intracellular staining kit and stained with 1 ug of TLR7-PE conjugate (red) or rabbit IgG-PE conjugate isotype control (NBP2-24983, green). Image using the PE form of this antibody." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/Rabbit--Mouse-IgG-Isotype-Control-Flow-Cytometry-NBP2-24891-img0003.jpg" title="Flow Cytometry: Rabbit IgG Isotype Control [NBP2-24891] - Intracellular analysis of TLR1 in human PBMCs (lymphocyte-gated) using this antibody. Shaded histogram represents cells alone, green represents isotype control , red represents TLR1 antibody. TLR intracellular flow kit was used for this test. Image using the Alexa Fluor 488 form of this antibody." class="big_lightbox"> <img src="//images.novusbio.com/images/Rabbit--Mouse-IgG-Isotype-Control-Flow-Cytometry-NBP2-24891-img0003.jpg" alt="Flow Cytometry: Rabbit IgG Isotype Control [NBP2-24891] - Intracellular analysis of TLR1 in human PBMCs (lymphocyte-gated) using this antibody. Shaded histogram represents cells alone, green represents isotype control , red represents TLR1 antibody. TLR intracellular flow kit was used for this test. Image using the Alexa Fluor 488 form of this antibody." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/Rabbit--Mouse-IgG-Isotype-Control-Flow-Cytometry-NBP2-24891-img0004.jpg" title="Flow Cytometry: Rabbit IgG Isotype Control [NBP2-24891] - Analysis of TLR7 in Ramos cells using 2 ug of NBP2-24892. Shaded histogram represents FITC-conjugated rabbit IgG isotype control ; red represents anti-TLR7 antibody. Image using the FITC form of this antibody." class="big_lightbox"> <img src="//images.novusbio.com/images/Rabbit--Mouse-IgG-Isotype-Control-Flow-Cytometry-NBP2-24891-img0004.jpg" alt="Flow Cytometry: Rabbit IgG Isotype Control [NBP2-24891] - Analysis of TLR7 in Ramos cells using 2 ug of NBP2-24892. Shaded histogram represents FITC-conjugated rabbit IgG isotype control ; red represents anti-TLR7 antibody. Image using the FITC form of this antibody." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/Rabbit--Mouse-IgG-Isotype-Control-Flow-Cytometry-NBP2-24891-img0005.jpg" title="Flow Cytometry: Rabbit IgG Isotype Control [NBP2-24891] - FLOW analysis of Mouse CD4+ T cells that were stimulated with anti-CD3/CD28 beads and insulin (1ug/mL) for 5 days in culture media with additional glucose provided. PE conjugated Glut1 antibody stained cells (NB110-39113PE, Orange) were included as positive control which were compared with Rb IgG PE, NBP2-24983 as Isotype Control (Blue) as well as with fluorescence minus one/FMO control (Red) [Image submitted by Verified Customer - see Review for Protocol Details]. Image using the PE form of this antibody." class="big_lightbox"> <img src="//images.novusbio.com/images/Rabbit--Mouse-IgG-Isotype-Control-Flow-Cytometry-NBP2-24891-img0005.jpg" alt="Flow Cytometry: Rabbit IgG Isotype Control [NBP2-24891] - FLOW analysis of Mouse CD4+ T cells that were stimulated with anti-CD3/CD28 beads and insulin (1ug/mL) for 5 days in culture media with additional glucose provided. PE conjugated Glut1 antibody stained cells (NB110-39113PE, Orange) were included as positive control which were compared with Rb IgG PE, NBP2-24983 as Isotype Control (Blue) as well as with fluorescence minus one/FMO control (Red) [Image submitted by Verified Customer - see Review for Protocol Details]. Image using the PE form of this antibody." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/nbp2-24891_rabbit-igg-isotype-control-31020241539599.jpg" title="Immunocytochemistry/ Immunofluorescence: Rabbit IgG Isotype Control [NBP2-24891] - The expression & localization of PRCP in the human atherosclerotic plaque. (A) Immunohistochemical staining of PRCP (brown color) in a carotid endarterectomy sample. Scale bars, 500 µm (left) & 50 µm (right). (B) A consecutive section of the carotid sample was immunofluorescently stained for PRCP (red) & Mac-2 (green), & counterstained with DAPI. Cells that clearly express both PRCP & Mac-2 are indicated by white arrows. Scale bars, 500 µm (left) & 50 µm (right). Image collected & cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/30305673), licensed under a CC-BY license. Not internally tested by Novus Biologicals." class="big_lightbox"> <img src="//images.novusbio.com/images/nbp2-24891_rabbit-igg-isotype-control-31020241539599.jpg" alt="Immunocytochemistry/ Immunofluorescence: Rabbit IgG Isotype Control [NBP2-24891] - The expression & localization of PRCP in the human atherosclerotic plaque. (A) Immunohistochemical staining of PRCP (brown color) in a carotid endarterectomy sample. Scale bars, 500 µm (left) & 50 µm (right). (B) A consecutive section of the carotid sample was immunofluorescently stained for PRCP (red) & Mac-2 (green), & counterstained with DAPI. Cells that clearly express both PRCP & Mac-2 are indicated by white arrows. Scale bars, 500 µm (left) & 50 µm (right). Image collected & cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/30305673), licensed under a CC-BY license. Not internally tested by Novus Biologicals." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/nbp2-24891_rabbit-igg-isotype-control-310202415392523.jpg" title="Immunohistochemistry: Rabbit IgG Isotype Control [NBP2-24891] - alpha -melanocyte stimulating hormone ( alpha -MSH) is expressed by plaque macrophages in human atheroma. (A) alpha -MSH immunostaining (brown color) of carotid endarterectomy sample. Scale bars, 200 µm (left) & 50 µm (right). (B) A consecutive section of the carotid sample was immunofluorescently stained for alpha -MSH (red) & Mac-2 (green), & counterstained with DAPI. Cells that clearly express both alpha -MSH & Mac-2 are indicated by white arrows. Scale bars, 200 µm (left) & 50 µm (right). Image collected & cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/30305673), licensed under a CC-BY license. Not internally tested by Novus Biologicals." class="big_lightbox"> <img src="//images.novusbio.com/images/nbp2-24891_rabbit-igg-isotype-control-310202415392523.jpg" alt="Immunohistochemistry: Rabbit IgG Isotype Control [NBP2-24891] - alpha -melanocyte stimulating hormone ( alpha -MSH) is expressed by plaque macrophages in human atheroma. (A) alpha -MSH immunostaining (brown color) of carotid endarterectomy sample. Scale bars, 200 µm (left) & 50 µm (right). (B) A consecutive section of the carotid sample was immunofluorescently stained for alpha -MSH (red) & Mac-2 (green), & counterstained with DAPI. Cells that clearly express both alpha -MSH & Mac-2 are indicated by white arrows. Scale bars, 200 µm (left) & 50 µm (right). Image collected & cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/30305673), licensed under a CC-BY license. Not internally tested by Novus Biologicals." class="big_thumb" /> </a> </div></div><div id="ss_next7" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-7" class="cycle-circle-pager"></div><div id="image-caption-NBP2-24891"></div> </div><div class="review_publication_wrapper forcol3"></div> <div class="product-attributes"><div class="field not3column"><label>Reactivity:</label><div class="value"><span title="Rabbit">Rb</span><div class="myModal">Species Glossary</div></div></div><div class="forcol3 bottom_margin"><strong>Reactivity:</strong> <span title="Rabbit">Rb</span></div><div class="field not3column"><label>Applications:</label><div class="value"><span class="application-tooltip-text" title="Chromatin Immunoprecipitation">ChIP</span>, <span class="application-tooltip-text" title="Flow Cytometry">Flow</span>, <span class="application-tooltip-text" title="Functional Assay">Func</span>, <span class="application-tooltip-text" title="Immunocytochemistry/ Immunofluorescence">ICC/IF</span>, <span class="application-tooltip-text" title="Immunohistochemistry">IHC</span>, <span class="application-tooltip-text" title="Chromatin Immunoprecipitation">ChIP</span></div></div><div class="forcol3 bottom_margin"><strong>Applications:</strong> <span class="application-tooltip-text" title="Chromatin Immunoprecipitation">ChIP</span>, <span class="application-tooltip-text" title="Flow Cytometry">Flow</span>, <span class="application-tooltip-text" title="Functional Assay">Func</span>, <span class="application-tooltip-text" title="Immunocytochemistry/ Immunofluorescence">ICC/IF</span>, <span class="application-tooltip-text" title="Immunohistochemistry">IHC</span>, <span class="application-tooltip-text" title="Chromatin Immunoprecipitation">ChIP</span></div><div class="field not3column"><label>Host:</label><div class="value">Rabbit Polyclonal</div></div><div class="forcol3 bottom_margin"><strong>Host:</strong> Rabbit Polyclonal</div><div class="field not3column"><label>Alt Catalog#</label><div class="value">20304</div></div><div class="forcol3 bottom_margin"><strong>Alt Catalog#</strong> 20304</div><div class="field not3column"><label>Conjugate:</label><div class="value">Unconjugated  <div class="list_expand not3column options_closed" data-name="Conjugates" data-wrapper-type=".conjugates_wrapper">Available Conjugates: <div class="expander option_closed"></div></div></div></div> </div><div class="forcol3 option_buttons_block"><button class="options_button" data-type="conjugates">Conjugates</button></div><div class="conjugates_wrapper" data-title="Rabbit IgG Isotype Control" data-catnum="NBP2-24891"><table class="scf_table"> <thead> <tr> <th>Conjugate</th> <th>Catalog #</th> <th class="head_avail">Availability</th> <th>Size</th> <th class="col_price">Price</th> </tr> </thead> <tbody><tr class="popup_sku" data-sku="NBP2-24891AF350"> <td><a href="/products/igg-antibody_nbp2-24891af350">Alexa Fluor 350</a></td> <td><a href="/products/igg-antibody_nbp2-24891af350">NBP2-24891AF350</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NBP2-24891AF405"> <td><a href="/products/igg-isotype-control_nbp2-24891af405">Alexa Fluor 405</a></td> <td><a href="/products/igg-isotype-control_nbp2-24891af405">NBP2-24891AF405</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NBP2-24982"> <td><a href="/products/igg-isotype-control_nbp2-24982">Alexa Fluor 488</a></td> <td><a href="/products/igg-isotype-control_nbp2-24982">NBP2-24982</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NBP2-24891AF532"> <td><a href="/products/igg-antibody_nbp2-24891af532">Alexa Fluor 532</a></td> <td><a href="/products/igg-antibody_nbp2-24891af532">NBP2-24891AF532</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NBP2-24891AF594"> <td><a href="/products/igg-isotype-control_nbp2-24891af594">Alexa Fluor 594</a></td> <td><a href="/products/igg-isotype-control_nbp2-24891af594">NBP2-24891AF594</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NBP2-24891AF647"> <td><a href="/products/igg-isotype-control_nbp2-24891af647">Alexa Fluor 647</a></td> <td><a href="/products/igg-isotype-control_nbp2-24891af647">NBP2-24891AF647</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NBP2-24891AF700"> <td><a href="/products/igg-isotype-control_nbp2-24891af700">Alexa Fluor 700</a></td> <td><a href="/products/igg-isotype-control_nbp2-24891af700">NBP2-24891AF700</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NBP2-24891AF750"> <td><a href="/products/igg-antibody_nbp2-24891af750">Alexa Fluor 750</a></td> <td><a href="/products/igg-antibody_nbp2-24891af750">NBP2-24891AF750</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NBP2-24891APC"> <td><a href="/products/igg-antibody_nbp2-24891apc">Allophycocyanin</a></td> <td><a href="/products/igg-antibody_nbp2-24891apc">NBP2-24891APC</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NBP2-24891APCCY7"> <td><a href="/products/igg-isotype-control_nbp2-24891apccy7">Allophycocyanin/Cy7</a></td> <td><a href="/products/igg-isotype-control_nbp2-24891apccy7">NBP2-24891APCCY7</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NBP2-24891B"> <td><a href="/products/igg-antibody_nbp2-24891b">Biotin</a></td> <td><a href="/products/igg-antibody_nbp2-24891b">NBP2-24891B</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NBP2-24891UV"> <td><a href="/products/igg-antibody_nbp2-24891uv">DyLight 350</a></td> <td><a href="/products/igg-antibody_nbp2-24891uv">NBP2-24891UV</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NBP2-24891V"> <td><a href="/products/igg-antibody_nbp2-24891v">DyLight 405</a></td> <td><a href="/products/igg-antibody_nbp2-24891v">NBP2-24891V</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NBP2-24891G"> <td><a href="/products/igg-isotype-control_nbp2-24891g">DyLight 488</a></td> <td><a href="/products/igg-isotype-control_nbp2-24891g">NBP2-24891G</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NBP2-24891R"> <td><a href="/products/igg-antibody_nbp2-24891r">DyLight 550</a></td> <td><a href="/products/igg-antibody_nbp2-24891r">NBP2-24891R</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NBP2-24891DL594"> <td><a href="/products/igg-antibody_nbp2-24891dl594">DyLight 594</a></td> <td><a href="/products/igg-antibody_nbp2-24891dl594">NBP2-24891DL594</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NBP2-24891C"> <td><a href="/products/igg-antibody_nbp2-24891c">DyLight 650</a></td> <td><a href="/products/igg-antibody_nbp2-24891c">NBP2-24891C</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NBP2-24891FR"> <td><a href="/products/igg-antibody_nbp2-24891fr">DyLight 680</a></td> <td><a href="/products/igg-antibody_nbp2-24891fr">NBP2-24891FR</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NBP2-24891IR"> <td><a href="/products/igg-antibody_nbp2-24891ir">DyLight 755</a></td> <td><a href="/products/igg-antibody_nbp2-24891ir">NBP2-24891IR</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NBP2-24892"> <td><a href="/products/igg-isotype-control_nbp2-24892">FITC</a></td> <td><a href="/products/igg-isotype-control_nbp2-24892">NBP2-24892</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NBP2-24891H"> <td><a href="/products/igg-antibody_nbp2-24891h">HRP</a></td> <td><a 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href="/products/igg-isotype-control_nbp2-24983">PE</a></td> <td><a href="/products/igg-isotype-control_nbp2-24983">NBP2-24983</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NBP2-24891PECY55"> <td><a href="/products/igg-antibody_nbp2-24891pecy55">PE/Cy5.5</a></td> <td><a href="/products/igg-antibody_nbp2-24891pecy55">NBP2-24891PECY55</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NBP2-24891PCP"> <td><a href="/products/igg-antibody_nbp2-24891pcp">PerCP</a></td> <td><a href="/products/igg-antibody_nbp2-24891pcp">NBP2-24891PCP</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr> <tr class="scf_footer"> <td 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data-compare='{"Catalog #":"NBP2-24891","Product Name":"Rabbit IgG Isotype Control","Description":"","Reactivity":"Rabbit","Applications":"ChIP, Flow, Func, ICC\/IF, IHC, ChIP","Source":"","Purification":"","Immunogen":"","Citations":"55","Purity":"Affinity purified","Activity":"","Accession #":"","N-terminal Sequence Analysis":"","Predicated Molecular Mass":"","SDS Page":"","Assay Type":"","Format":"","Assay Length":"","Sample Type and Volume Required":"","Sensitivity":"","Interference":"","Datasheet":"<a href=\"\/products\/igg-isotype-control_nbp2-24891\">view datasheet<\/a>","Price":"Price Not Shown"}'><div class="search_compare">compare</div> <div class="search_compare_text">(select up to 3 products from this page to compare)</div> </div> <div class="clear"></div> </div><div class="new-search-result search-result-wrapper" > <div class="name"><span> <div class="catalog_number_wrapper not3column"> <a href="/products/igg-isotype-control_1-001-a">1-001-A</a> </div><h2 class="col3_hdr"><a data-brand="rnd" data-id="1-001-A" data-name="Human IgG Isotype Control [Unconjugated]" data-position="9" class="ecommerce_link" href="/products/igg-isotype-control_1-001-a" title="Human IgG Isotype Control [Unconjugated]" ><span> Human IgG Isotype Control [Unconjugated]</span></a></div></h2> <div class="sub-header"> <div class="flourish_left"></div> <div class="flourish_right"></div><div class="prod_details_section"> <div class="segment"> <a title="1 Review for this product" href="/products/igg-isotype-control_1-001-a#ReviewsSection"><span class="stars4"></span> (1 Review)</a> </div> <div class="segment"> <a title="56 Publications specific to this product" href="/products/igg-isotype-control_1-001-a#PublicationSection"><span class="publications"></span> (56 Publications)</a> </div> <div class="segment" style="float:right;"> <strong>1 mg</strong><span class="product_price" data-sku="1-001-A"></span> </div> </div> </div> <div class="images"> <div class="catalog_number_wrapper_col3 forcol3"> <a href="/products/igg-isotype-control_1-001-a">1-001-A</a> </div><div class="cycle-slideshow slideshows" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-8" data-cycle-prev="#ss_prev8" data-cycle-next="#ss_next8" data-cycle-caption="#image-caption-1-001-A" data-cycle-caption-template="Image {{slideNum}} / {{slideCount}}" data-cycle-slides=".big_thumb_container" ><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/1-001-a_normal-human-igg-control-8220249505946.jpg" title="Activated ADSCs trigger the proliferation and invasion of lung cancer cells by regulating MMP2/9 expression and EMT. a The effects of activated ADSCs on lung cancer cell proliferation were evaluated using the CCK-8 assay. Four lung cancer cell lines were cultured in the presence of ADSC-CM or aADSC-CM, and the optical density at 450 nm was analysed. The cancer cells cultured alone in normal growth medium were used as negative controls. Data from three separate experiments are shown. b The number of lung cancer cells that migrated through 8-μm Transwell membrane pores was counted to determine the changes in the invasive capabilities in response to CM from epidural ADSCs or aADSCs. c MMP2/9, E-cadherin and vimentin expression levels in four lung cancer cell lines treated with ADSC-CM or aADSC-CM were examined by western blotting. Lung cancer cells cultured in an untreated medium served as controls. d Lung cancer cells were treated with neutralizing antibodies against IL-6, isotype controls and aADSC-CM. Lung cancer cell invasion was analysed using a Transwell assay. Lung cancer cells cultured with untreated medium served as negative controls. e Lung cancer cells were treated with neutralizing antibodies against IL-6, isotype controls and aADSC-CM. MMP2/9, E-cadherin and vimentin expression levels in four lung cancer cell lines were analysed using western blotting. Lung cancer cells cultured with untreated medium served as negative controls. ***P < 0.001. Image collected and cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/31196220), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/1-001-a_normal-human-igg-control-8220249505946.jpg" title="Activated ADSCs trigger the proliferation and invasion of lung cancer cells by regulating MMP2/9 expression and EMT. a The effects of activated ADSCs on lung cancer cell proliferation were evaluated using the CCK-8 assay. Four lung cancer cell lines were cultured in the presence of ADSC-CM or aADSC-CM, and the optical density at 450 nm was analysed. The cancer cells cultured alone in normal growth medium were used as negative controls. Data from three separate experiments are shown. b The number of lung cancer cells that migrated through 8-μm Transwell membrane pores was counted to determine the changes in the invasive capabilities in response to CM from epidural ADSCs or aADSCs. c MMP2/9, E-cadherin and vimentin expression levels in four lung cancer cell lines treated with ADSC-CM or aADSC-CM were examined by western blotting. Lung cancer cells cultured in an untreated medium served as controls. d Lung cancer cells were treated with neutralizing antibodies against IL-6, isotype controls and aADSC-CM. Lung cancer cell invasion was analysed using a Transwell assay. Lung cancer cells cultured with untreated medium served as negative controls. e Lung cancer cells were treated with neutralizing antibodies against IL-6, isotype controls and aADSC-CM. MMP2/9, E-cadherin and vimentin expression levels in four lung cancer cell lines were analysed using western blotting. Lung cancer cells cultured with untreated medium served as negative controls. ***P < 0.001. Image collected and cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/31196220), licensed under a CC-BY license. Not internally tested by R&D Systems." alt="Activated ADSCs trigger the proliferation and invasion of lung cancer cells by regulating MMP2/9 expression and EMT. a The effects of activated ADSCs on lung cancer cell proliferation were evaluated using the CCK-8 assay. Four lung cancer cell lines were cultured in the presence of ADSC-CM or aADSC-CM, and the optical density at 450 nm was analysed. The cancer cells cultured alone in normal growth medium were used as negative controls. Data from three separate experiments are shown. b The number of lung cancer cells that migrated through 8-μm Transwell membrane pores was counted to determine the changes in the invasive capabilities in response to CM from epidural ADSCs or aADSCs. c MMP2/9, E-cadherin and vimentin expression levels in four lung cancer cell lines treated with ADSC-CM or aADSC-CM were examined by western blotting. Lung cancer cells cultured in an untreated medium served as controls. d Lung cancer cells were treated with neutralizing antibodies against IL-6, isotype controls and aADSC-CM. Lung cancer cell invasion was analysed using a Transwell assay. Lung cancer cells cultured with untreated medium served as negative controls. e Lung cancer cells were treated with neutralizing antibodies against IL-6, isotype controls and aADSC-CM. MMP2/9, E-cadherin and vimentin expression levels in four lung cancer cell lines were analysed using western blotting. Lung cancer cells cultured with untreated medium served as negative controls. ***P < 0.001. Image collected and cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/31196220), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div></div><div class="pager_fill"></div><div id="image-caption-1-001-A"></div> </div><div class="review_publication_wrapper forcol3"></div> <div class="product-attributes"><div class="field not3column"><label>Reactivity:</label><div class="value"><span title="Human">Hu</span><div class="myModal">Species Glossary</div></div></div><div class="forcol3 bottom_margin"><strong>Reactivity:</strong> <span title="Human">Hu</span></div><div class="field not3column"><label>Applications:</label><div class="value"><span class="application-tooltip-text" title="Control">Ctrl</span></div></div><div class="forcol3 bottom_margin"><strong>Applications:</strong> <span class="application-tooltip-text" title="Control">Ctrl</span></div><div class="field not3column"><label>Host:</label><div class="value">Human Polyclonal</div></div><div class="forcol3 bottom_margin"><strong>Host:</strong> Human Polyclonal</div><div class="field not3column"><label>Conjugate:</label><div class="value">Unconjugated  </div></div> </div> <div class="compare_block"><input type="checkbox" class="search_compare_checkbox" data-compare='{"Catalog #":"1-001-A","Product Name":"Normal Human IgG Control","Description":"","Reactivity":"Human","Applications":"Ctrl","Source":"","Purification":"","Immunogen":"Normal human plasma (Donor plasma tested and found negative for HBsAg, HIV-1, HIV-2 and HCV antibodies by FDA approved tests)","Citations":"56","Purity":"","Activity":"","Accession #":"","N-terminal Sequence Analysis":"","Predicated Molecular Mass":"","SDS Page":"","Assay Type":"","Format":"","Assay Length":"","Sample Type and Volume Required":"","Sensitivity":"","Interference":"","Datasheet":"<a href=\"\/products\/igg-isotype-control_1-001-a\">view datasheet<\/a>","Price":"Price Not Shown"}'><div class="search_compare">compare</div> <div class="search_compare_text">(select up to 3 products from this page to compare)</div> </div> <div class="clear"></div> </div><div class="new-search-result search-result-wrapper" > <div class="name"><span> <div class="catalog_number_wrapper not3column"> <a href="/products/igg2b-isotype-control-141945_mab0061">MAB0061</a> </div><h2 class="col3_hdr"><a data-brand="rnd" data-id="MAB0061" data-name="Rat IgG2b Isotype Control (141945) [Unconjugated]" data-position="10" class="ecommerce_link" href="/products/igg2b-isotype-control-141945_mab0061" title="Rat IgG2b Isotype Control (141945) [Unconjugated]" ><span> Rat IgG2b Isotype Control (141945) [Unconjugated]</span></a></div></h2> <div class="sub-header"> <div class="flourish_left"></div> <div class="flourish_right"></div><div class="prod_details_section"> <div class="segment"> <a title="57 Publications specific to this product" href="/products/igg2b-isotype-control-141945_mab0061#PublicationSection"><span class="publications"></span> (57 Publications)</a> </div> <div class="segment" style="float:right;"> <strong>500 μg</strong><span class="product_price" data-sku="MAB0061"></span> </div> </div> </div> <div class="images"> <div class="catalog_number_wrapper_col3 forcol3"> <a href="/products/igg2b-isotype-control-141945_mab0061">MAB0061</a> </div><div class="cycle-slideshow slideshows" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-9" data-cycle-prev="#ss_prev9" data-cycle-next="#ss_next9" data-cycle-caption="#image-caption-MAB0061" data-cycle-caption-template="Image {{slideNum}} / {{slideCount}}" data-cycle-slides=".big_thumb_container" ><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize2/IgG2B_MAB0061_Control_19427.jpg" title="Human peripheral blood mononuclear cells (PBMCs) werestained with Rat Anti-Mouse CD44 Monoclonal Antibody (Catalog # MAB6127,filled histogram) or Rat IgG Isotype Control Antibody (Catalog #MAB0061,open histogram), followed by Phycoerythrin-conjugated Anti-Rat IgG SecondaryAntibody (Catalog # F0105B)." class="big_lightbox"> <img src="//images.novusbio.com/images2/IgG2B_MAB0061_Control_19427.jpg" title="Human peripheral blood mononuclear cells (PBMCs) werestained with Rat Anti-Mouse CD44 Monoclonal Antibody (Catalog # MAB6127,filled histogram) or Rat IgG Isotype Control Antibody (Catalog #MAB0061,open histogram), followed by Phycoerythrin-conjugated Anti-Rat IgG SecondaryAntibody (Catalog # F0105B)." alt="Human peripheral blood mononuclear cells (PBMCs) werestained with Rat Anti-Mouse CD44 Monoclonal Antibody (Catalog # MAB6127,filled histogram) or Rat IgG Isotype Control Antibody (Catalog #MAB0061,open histogram), followed by Phycoerythrin-conjugated Anti-Rat IgG SecondaryAntibody (Catalog # F0105B)." class="big_thumb" /> </a> </div></div><div class="pager_fill"></div><div id="image-caption-MAB0061"></div> </div><div class="review_publication_wrapper forcol3"></div> <div class="product-attributes"><div class="field not3column"><label>Reactivity:</label><div class="value"><span title="Rat">Rt</span><div class="myModal">Species Glossary</div></div></div><div class="forcol3 bottom_margin"><strong>Reactivity:</strong> <span title="Rat">Rt</span></div><div class="field not3column"><label>Applications:</label><div class="value"><span class="application-tooltip-text" title="Control">Ctrl</span></div></div><div class="forcol3 bottom_margin"><strong>Applications:</strong> <span class="application-tooltip-text" title="Control">Ctrl</span></div><div class="field not3column"><label>Host:</label><div class="value">Rat Monoclonal</div></div><div class="forcol3 bottom_margin"><strong>Host:</strong> Rat Monoclonal</div><div class="field not3column"><label>Conjugate:</label><div class="value">Unconjugated  <div class="list_expand not3column options_closed" data-name="Conjugates" data-wrapper-type=".conjugates_wrapper">Available Conjugates: <div class="expander option_closed"></div></div></div></div> </div><div class="forcol3 option_buttons_block"><button class="options_button" data-type="conjugates">Conjugates</button></div><div class="conjugates_wrapper" data-title="Rat IgG2b Isotype Control (141945) [Unconjugated]" data-catnum="MAB0061"><table class="scf_table"> <thead> <tr> <th>Conjugate</th> <th>Catalog #</th> <th class="head_avail">Availability</th> <th>Size</th> <th class="col_price">Price</th> </tr> </thead> <tbody><tr class="popup_sku" data-sku="IC013V"> <td><a href="/products/igg2b-isotype-control-141945_ic013v">Alexa Fluor 405</a></td> <td><a href="/products/igg2b-isotype-control-141945_ic013v">IC013V</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC013G"> <td><a href="/products/igg2b-isotype-control-141945_ic013g">Alexa Fluor 488</a></td> <td><a href="/products/igg2b-isotype-control-141945_ic013g">IC013G</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC013T"> <td><a href="/products/igg2b-isotype-control-141945_ic013t">Alexa Fluor 594</a></td> <td><a href="/products/igg2b-isotype-control-141945_ic013t">IC013T</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC013R"> <td><a href="/products/igg2b-isotype-control-141945_ic013r">Alexa Fluor 647</a></td> <td><a href="/products/igg2b-isotype-control-141945_ic013r">IC013R</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC013N"> <td><a href="/products/igg2b-isotype-control-141945_ic013n">Alexa Fluor 700</a></td> <td><a href="/products/igg2b-isotype-control-141945_ic013n">IC013N</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC013S"> <td><a href="/products/igg2b-isotype-control-141945_ic013s">Alexa Fluor 750</a></td> <td><a href="/products/igg2b-isotype-control-141945_ic013s">IC013S</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC013A"> <td><a href="/products/igg2b-isotype-control-141945_ic013a">Allophycocyanin</a></td> <td><a href="/products/igg2b-isotype-control-141945_ic013a">IC013A</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC013B"> <td><a href="/products/igg2b-isotype-control-141945_ic013b">Biotin</a></td> <td><a href="/products/igg2b-isotype-control-141945_ic013b">IC013B</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC013F"> <td><a href="/products/igg2b-isotype-control-141945_ic013f">Fluorescein</a></td> <td><a href="/products/igg2b-isotype-control-141945_ic013f">IC013F</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC013C"> <td><a href="/products/igg2b-isotype-control-141945_ic013c">PerCP (Peridinin-chlorophyll Protein Complex)</a></td> <td><a href="/products/igg2b-isotype-control-141945_ic013c">IC013C</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC013P"> <td><a href="/products/igg2b-isotype-control-141945_ic013p">Phycoerythrin</a></td> <td><a href="/products/igg2b-isotype-control-141945_ic013p">IC013P</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr> <tr class="scf_footer"> <td colspan="5"><div class="expander option_opened"></div></td> </tr> </tbody> </table> <div class="popup_skus" data-skus='["IC013V","IC013G","IC013T","IC013R","IC013N","IC013S","IC013A","IC013B","IC013F","IC013C","IC013P"]' data-rendered="false"></div></div><div class="product-attributes" style="margin-top:-10px;padding-top:0px;"><div class="field not3column"><label>&nbsp</label><div class="value"><div class="list_expand not3column options_closed" data-name="Formulations" data-wrapper-type=".formulations_wrapper" style="margin-left:0px;">Available Formulations <div class="expander option_closed"></div></div></div></div></div><div class="forcol3 option_buttons_block"><button class="options_button" data-type="formulations">Formulations</button></div><div class="formulations_wrapper" data-title="Rat IgG2b Isotype Control (141945) [Unconjugated]" data-catnum="MAB0061"><table class="scf_table"> <thead> <tr> <th>Formulation</th> <th>Catalog #</th> <th>Availability</th> <th>Price</th> <th> </th> </tr> </thead> <tbody><tr class="popup_sku" data-sku="IC013A"> <td><a href="/products/igg2b-isotype-control-141945_ic013a">Carrier Free</a></td> <td><a href="/products/igg2b-isotype-control-141945_ic013a">IC013A</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/416192"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC013B"> <td><a href="/products/igg2b-isotype-control-141945_ic013b">Carrier Free</a></td> <td><a href="/products/igg2b-isotype-control-141945_ic013b">IC013B</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a 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href="/products/igg2b-isotype-control-141945_ic013g">IC013G</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/416196"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC013N"> <td><a href="/products/igg2b-isotype-control-141945_ic013n">Carrier Free</a></td> <td><a href="/products/igg2b-isotype-control-141945_ic013n">IC013N</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/416197"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC013P"> <td><a href="/products/igg2b-isotype-control-141945_ic013p">Carrier Free</a></td> <td><a href="/products/igg2b-isotype-control-141945_ic013p">IC013P</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/416198"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC013S"> <td><a href="/products/igg2b-isotype-control-141945_ic013s">Carrier Free</a></td> <td><a href="/products/igg2b-isotype-control-141945_ic013s">IC013S</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/448845"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC013T"> <td><a href="/products/igg2b-isotype-control-141945_ic013t">Carrier Free</a></td> <td><a href="/products/igg2b-isotype-control-141945_ic013t">IC013T</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/448855"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC013R"> <td><a href="/products/igg2b-isotype-control-141945_ic013r">Carrier Free</a></td> <td><a href="/products/igg2b-isotype-control-141945_ic013r">IC013R</a></td> <td><div class="popup_stock"></div></td> <td><div 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class="ecommerce_link" href="/products/igg-isotype-control_nb810-56910" title="Rabbit IgG Isotype Control" ><span> Rabbit IgG Isotype Control</span></a></div></h2> <div class="sub-header"> <div class="flourish_left"></div> <div class="flourish_right"></div><div class="prod_details_section"> <div class="segment"> <a title="6 Reviews for this product" href="/products/igg-isotype-control_nb810-56910#ReviewsSection"><span class="stars5"></span> (6 Reviews)</a> </div> <div class="segment"> <a title="50 Publications specific to this product" href="/products/igg-isotype-control_nb810-56910#PublicationSection"><span class="publications"></span> (50 Publications)</a> </div> <div class="segment" style="float:right;"> <strong>10 mg</strong><span class="product_price" data-sku="NB810-56910-10mg"></span> </div> </div> </div> <div class="images"> <div class="catalog_number_wrapper_col3 forcol3"> <a href="/products/igg-isotype-control_nb810-56910">NB810-56910</a> </div><div id="ss_prev10" class="cycle-pager"><div class="pager_left_on"></div></div><div class="cycle-slideshow slideshows" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-10" data-cycle-prev="#ss_prev10" data-cycle-next="#ss_next10" data-cycle-caption="#image-caption-NB810-56910" data-cycle-caption-template="Image {{slideNum}} / {{slideCount}}" data-cycle-slides=".big_thumb_container" ><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/Rabbit-IgG-Isotype-Control-Immunohistochemistry-Frozen-NB810-56910-img0012.jpg" title="Immunohistochemistry-Frozen: Rabbit IgG Isotype Control [NB810-56910] - Mouse ear skin (aceton-fixed frozen section) stained with rabbit IgG isotype control, which was used as a negative control. Image from verified customer review." class="big_lightbox"> <img src="//images.novusbio.com/images/Rabbit-IgG-Isotype-Control-Immunohistochemistry-Frozen-NB810-56910-img0012.jpg" title="Immunohistochemistry-Frozen: Rabbit IgG Isotype Control [NB810-56910] - Mouse ear skin (aceton-fixed frozen section) stained with rabbit IgG isotype control, which was used as a negative control. Image from verified customer review." alt="Immunohistochemistry-Frozen: Rabbit IgG Isotype Control [NB810-56910] - Mouse ear skin (aceton-fixed frozen section) stained with rabbit IgG isotype control, which was used as a negative control. Image from verified customer review." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/Rabbit-IgG-Isotype-Control-Immunohistochemistry-Frozen-NB810-56910-img0011.jpg" title="Immunohistochemistry-Frozen: Rabbit IgG Isotype Control [NB810-56910] - Mouse ear skin (aceton-fixed frozen section) stained with rabbit IgG isotype control, which was used as a negative control. Image from verified customer review." class="big_lightbox"> <img src="//images.novusbio.com/images/Rabbit-IgG-Isotype-Control-Immunohistochemistry-Frozen-NB810-56910-img0011.jpg" alt="Immunohistochemistry-Frozen: Rabbit IgG Isotype Control [NB810-56910] - Mouse ear skin (aceton-fixed frozen section) stained with rabbit IgG isotype control, which was used as a negative control. Image from verified customer review." class="big_thumb" /> </a> </div></div><div id="ss_next10" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-10" class="cycle-circle-pager"></div><div id="image-caption-NB810-56910"></div> </div><div class="review_publication_wrapper forcol3"></div> <div class="product-attributes"><div class="field not3column"><label>Reactivity:</label><div class="value"><span title="Rabbit">Rb</span><div class="myModal">Species Glossary</div></div></div><div class="forcol3 bottom_margin"><strong>Reactivity:</strong> <span title="Rabbit">Rb</span></div><div class="field not3column"><label>Applications:</label><div class="value"><span class="application-tooltip-text" title="Western Blot">WB</span>, <span class="application-tooltip-text" title="Flow Cytometry">Flow</span>, <span class="application-tooltip-text" title="Immunocytochemistry/ Immunofluorescence">ICC/IF</span>, <span class="application-tooltip-text" title="Immunohistochemistry">IHC</span>, <span class="application-tooltip-text" title="Immunoprecipitation">IP</span>, <span class="application-tooltip-text" title="Chromatin Immunoprecipitation">ChIP</span></div></div><div class="forcol3 bottom_margin"><strong>Applications:</strong> <span class="application-tooltip-text" title="Western Blot">WB</span>, <span class="application-tooltip-text" title="Flow Cytometry">Flow</span>, <span class="application-tooltip-text" title="Immunocytochemistry/ Immunofluorescence">ICC/IF</span>, <span class="application-tooltip-text" title="Immunohistochemistry">IHC</span>, <span class="application-tooltip-text" title="Immunoprecipitation">IP</span>, <span class="application-tooltip-text" title="Chromatin Immunoprecipitation">ChIP</span></div><div class="field not3column"><label>Host:</label><div class="value">Rabbit Polyclonal</div></div><div class="forcol3 bottom_margin"><strong>Host:</strong> Rabbit Polyclonal</div><div class="field not3column"><label>Conjugate:</label><div class="value">Unconjugated  </div></div> </div> <div class="compare_block"><input type="checkbox" class="search_compare_checkbox" data-compare='{"Catalog #":"NB810-56910","Product Name":"Rabbit IgG Isotype Control","Description":"","Reactivity":"Rabbit","Applications":"WB, Flow, ICC\/IF, IHC, IP, ChIP","Source":"","Purification":"","Immunogen":"","Citations":"50","Purity":"Ion exchange chromatography","Activity":"","Accession #":"","N-terminal Sequence Analysis":"","Predicated Molecular Mass":"","SDS Page":"","Assay Type":"","Format":"","Assay Length":"","Sample Type and Volume Required":"","Sensitivity":"","Interference":"","Datasheet":"<a href=\"\/products\/igg-isotype-control_nb810-56910\">view datasheet<\/a>","Price":"Price Not Shown"}'><div class="search_compare">compare</div> <div class="search_compare_text">(select up to 3 products from this page to compare)</div> </div> <div class="clear"></div> </div><div class="new-search-result search-result-wrapper" > <div class="name"><span> <div class="catalog_number_wrapper not3column"> <a href="/products/igg-isotype-control_5-001-a">5-001-A</a> </div><h2 class="col3_hdr"><a data-brand="rnd" data-id="5-001-A" data-name="Sheep IgG Isotype Control [Unconjugated]" data-position="12" class="ecommerce_link" href="/products/igg-isotype-control_5-001-a" title="Sheep IgG Isotype Control [Unconjugated]" ><span> Sheep IgG Isotype Control [Unconjugated]</span></a></div></h2> <div class="sub-header"> <div class="flourish_left"></div> <div class="flourish_right"></div><div class="prod_details_section"> <div class="segment"> <a title="1 Review for this product" href="/products/igg-isotype-control_5-001-a#ReviewsSection"><span class="stars5"></span> (1 Review)</a> </div> <div class="segment"> <a title="42 Publications specific to this product" href="/products/igg-isotype-control_5-001-a#PublicationSection"><span class="publications"></span> (42 Publications)</a> </div> <div class="segment" style="float:right;"> <strong>1 mg</strong><span class="product_price" data-sku="5-001-A"></span> </div> </div> </div> <div class="images"> <div class="catalog_number_wrapper_col3 forcol3"> <a href="/products/igg-isotype-control_5-001-a">5-001-A</a> </div><div class="cycle-slideshow slideshows" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-11" data-cycle-prev="#ss_prev11" data-cycle-next="#ss_next11" data-cycle-caption="#image-caption-5-001-A" data-cycle-caption-template="Image {{slideNum}} / {{slideCount}}" data-cycle-slides=".big_thumb_container" ><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/5-001-a_normal-sheep-igg-control-44202415425084.jpg" title="Effects of SDF-1-CXCR4/CXCR7 pathway on MSC chemotaxis in vitro.(A) The chemotaxis in response to SDF-1 alpha (10 ng/ml for 12 h) was performed in the NP-MSCs and HP-MSCs treated with a neutralizing anti-CXCR4 antibody, an anti-CXCR7 antibody, and the respective isotype-matched control antibodies. *P<0.05, vs NP-MSCs; †P<0.05, vs the respective isotype-matched control antibodies. (B) NP-MSCs were transiently overexpressed with CXCR4 using pORF9-mCXCR4 vector or with CXCR7 using pORF9-mCXCR7 vector (n = 6). A negative control empty (pORF9-MCS) vector was used. (C) The transfected cells were subjected to chemotaxis in response to the indicated concentrations of SDF-1 alpha for 12 h. *P<0.05, vs the empty vector. (D and E) Western blot analysis (D) and FCM (E) were performed to determine the intracellular and extracellular expression of both CXCR4 and CXCR7 in the cells treated with or without SDF-1 alpha (50 ng/ml for 60 min). (F) The chemotaxis in response to SDF-1 alpha was performed in the cells treated with or without SDF-1 alpha . Image collected and cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/22511954), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/5-001-a_normal-sheep-igg-control-44202415425084.jpg" title="Effects of SDF-1-CXCR4/CXCR7 pathway on MSC chemotaxis in vitro.(A) The chemotaxis in response to SDF-1 alpha (10 ng/ml for 12 h) was performed in the NP-MSCs and HP-MSCs treated with a neutralizing anti-CXCR4 antibody, an anti-CXCR7 antibody, and the respective isotype-matched control antibodies. *P<0.05, vs NP-MSCs; †P<0.05, vs the respective isotype-matched control antibodies. (B) NP-MSCs were transiently overexpressed with CXCR4 using pORF9-mCXCR4 vector or with CXCR7 using pORF9-mCXCR7 vector (n = 6). A negative control empty (pORF9-MCS) vector was used. (C) The transfected cells were subjected to chemotaxis in response to the indicated concentrations of SDF-1 alpha for 12 h. *P<0.05, vs the empty vector. (D and E) Western blot analysis (D) and FCM (E) were performed to determine the intracellular and extracellular expression of both CXCR4 and CXCR7 in the cells treated with or without SDF-1 alpha (50 ng/ml for 60 min). (F) The chemotaxis in response to SDF-1 alpha was performed in the cells treated with or without SDF-1 alpha . Image collected and cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/22511954), licensed under a CC-BY license. Not internally tested by R&D Systems." alt="Effects of SDF-1-CXCR4/CXCR7 pathway on MSC chemotaxis in vitro.(A) The chemotaxis in response to SDF-1 alpha (10 ng/ml for 12 h) was performed in the NP-MSCs and HP-MSCs treated with a neutralizing anti-CXCR4 antibody, an anti-CXCR7 antibody, and the respective isotype-matched control antibodies. *P<0.05, vs NP-MSCs; †P<0.05, vs the respective isotype-matched control antibodies. (B) NP-MSCs were transiently overexpressed with CXCR4 using pORF9-mCXCR4 vector or with CXCR7 using pORF9-mCXCR7 vector (n = 6). A negative control empty (pORF9-MCS) vector was used. (C) The transfected cells were subjected to chemotaxis in response to the indicated concentrations of SDF-1 alpha for 12 h. *P<0.05, vs the empty vector. (D and E) Western blot analysis (D) and FCM (E) were performed to determine the intracellular and extracellular expression of both CXCR4 and CXCR7 in the cells treated with or without SDF-1 alpha (50 ng/ml for 60 min). (F) The chemotaxis in response to SDF-1 alpha was performed in the cells treated with or without SDF-1 alpha . Image collected and cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/22511954), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div></div><div class="pager_fill"></div><div id="image-caption-5-001-A"></div> </div><div class="review_publication_wrapper forcol3"></div> <div class="product-attributes"><div class="field not3column"><label>Reactivity:</label><div class="value"><span title="Sheep">Sh</span><div class="myModal">Species Glossary</div></div></div><div class="forcol3 bottom_margin"><strong>Reactivity:</strong> <span title="Sheep">Sh</span></div><div class="field not3column"><label>Applications:</label><div class="value"><span class="application-tooltip-text" title="Control">Ctrl</span></div></div><div class="forcol3 bottom_margin"><strong>Applications:</strong> <span class="application-tooltip-text" title="Control">Ctrl</span></div><div class="field not3column"><label>Host:</label><div class="value">Sheep Polyclonal</div></div><div class="forcol3 bottom_margin"><strong>Host:</strong> Sheep Polyclonal</div><div class="field not3column"><label>Conjugate:</label><div class="value">Unconjugated  <div class="list_expand not3column options_closed" data-name="Conjugates" data-wrapper-type=".conjugates_wrapper">Available Conjugates: <div class="expander option_closed"></div></div></div></div> </div><div class="forcol3 option_buttons_block"><button class="options_button" data-type="conjugates">Conjugates</button></div><div class="conjugates_wrapper" data-title="Sheep IgG Isotype Control [Unconjugated]" data-catnum="5-001-A"><table class="scf_table"> <thead> <tr> <th>Conjugate</th> <th>Catalog #</th> <th class="head_avail">Availability</th> <th>Size</th> <th class="col_price">Price</th> </tr> </thead> <tbody><tr class="popup_sku" data-sku="IC016G"> <td><a href="/products/igg-isotype-control_ic016g">Alexa Fluor 488</a></td> <td><a href="/products/igg-isotype-control_ic016g">IC016G</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC016R"> <td><a href="/products/igg-isotype-control_ic016r">Alexa Fluor 647</a></td> <td><a href="/products/igg-isotype-control_ic016r">IC016R</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC016N-100UG"> <td><a href="/products/igg-isotype-control_ic016n">Alexa Fluor 700</a></td> <td><a href="/products/igg-isotype-control_ic016n">IC016N-100UG</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC016A"> <td><a href="/products/igg-isotype-control_ic016a">Allophycocyanin</a></td> <td><a href="/products/igg-isotype-control_ic016a">IC016A</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="BAF020"> <td><a href="/products/igg-isotype-control_baf020">Biotin</a></td> <td><a href="/products/igg-isotype-control_baf020">BAF020</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC016F"> <td><a href="/products/igg-isotype-control_ic016f">Fluorescein</a></td> <td><a href="/products/igg-isotype-control_ic016f">IC016F</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="IC016P"> <td><a href="/products/igg-isotype-control_ic016p">Phycoerythrin</a></td> <td><a href="/products/igg-isotype-control_ic016p">IC016P</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr> <tr class="scf_footer"> <td colspan="5"><div class="expander option_opened"></div></td> </tr> </tbody> </table> <div class="popup_skus" data-skus='["IC016G","IC016R","IC016N-100UG","IC016A","BAF020","IC016F","IC016P"]' data-rendered="false"></div></div><div class="product-attributes" style="margin-top:-10px;padding-top:0px;"><div class="field not3column"><label>&nbsp</label><div class="value"><div class="list_expand not3column options_closed" data-name="Formulations" data-wrapper-type=".formulations_wrapper" style="margin-left:0px;">Available Formulations <div class="expander option_closed"></div></div></div></div></div><div class="forcol3 option_buttons_block"><button class="options_button" data-type="formulations">Formulations</button></div><div class="formulations_wrapper" data-title="Sheep IgG Isotype Control [Unconjugated]" data-catnum="5-001-A"><table class="scf_table"> <thead> <tr> <th>Formulation</th> <th>Catalog #</th> <th>Availability</th> <th>Price</th> <th> </th> </tr> </thead> <tbody><tr class="popup_sku" data-sku="IC016N-100UG"> <td><a href="/products/igg-isotype-control_ic016n">Carrier Free</a></td> <td><a href="/products/igg-isotype-control_ic016n">IC016N-100UG</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/1254739"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC016A"> <td><a href="/products/igg-isotype-control_ic016a">Carrier Free</a></td> <td><a href="/products/igg-isotype-control_ic016a">IC016A</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/416204"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC016F"> <td><a href="/products/igg-isotype-control_ic016f">Carrier Free</a></td> <td><a href="/products/igg-isotype-control_ic016f">IC016F</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/416206"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC016G"> <td><a href="/products/igg-isotype-control_ic016g">Carrier Free</a></td> <td><a href="/products/igg-isotype-control_ic016g">IC016G</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/416207"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC016P"> <td><a href="/products/igg-isotype-control_ic016p">Carrier Free</a></td> <td><a href="/products/igg-isotype-control_ic016p">IC016P</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/416209"><div class="purchase_cart"></div></a></td> </tr><tr class="popup_sku" data-sku="IC016R"> <td><a href="/products/igg-isotype-control_ic016r">Carrier Free</a></td> <td><a 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