Neural Filtering of Physiological Tremor Oscillations to Spinal Motor Neurons Mediates Short-Term Acquisition of a Skill Learning Task

<!DOCTYPE html> <html lang="en"> <head> <meta charset="UTF-8"> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <title> Neural Filtering of Physiological Tremor Oscillations to Spinal Motor Neurons Mediates Short-Term Acquisition of a Skill Learning Task - FAU CRIS </title> <link rel="shortcut icon" type="image/svg" href="/static/img/cris-logo-onblue.svg"/> <link rel="stylesheet" href="/static/css/_global.css"> <link rel="stylesheet" href="/static/css/_layout.css"> <link rel="stylesheet" href="/static/css/slider.css"> </head> <body> <div id="header"> <div class="content"> <a href="/"><img id="fau-logo" src="/static/img/FAU_Kernmarke.svg" alt="FAU-Logo"> </a> <div class="links"> <a href="https://fau.de" class="secondary">FAU.de</a> <a class="secondary" href='#' onclick="document.getElementById('language_form').submit()">Deutsch</a> <form action="/i18n/setlang/" method="post" id="language_form"><input type="hidden" name="csrfmiddlewaretoken" value="glv9GSoIW1QoqeeFk54jalcD6Rmu2Gq2GIHzvYhq9ETCcSxoGEgg5DToh0Jq8rBR"> <input name="next" type="hidden" value=""> <input name="language" type="hidden" value="de">  </form> <a href="https://cris.fau.de/converis/mypages/overview" class="primary">Login</a> </div> <div class="mobile"> <a class="primary" onclick="document.body.classList.toggle('navopen')"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512"><path d="M0 96C0 78.3 14.3 64 32 64H416c17.7 0 32 14.3 32 32s-14.3 32-32 32H32C14.3 128 0 113.7 0 96zM0 256c0-17.7 14.3-32 32-32H416c17.7 0 32 14.3 32 32s-14.3 32-32 32H32c-17.7 0-32-14.3-32-32zM448 416c0 17.7-14.3 32-32 32H32c-17.7 0-32-14.3-32-32s14.3-32 32-32H416c17.7 0 32 14.3 32 32z" fill="currentColor"/></svg> </a> </div> </div> </div> <div id="app"> <div id="sidebar"> <a href="/" active="">Home</a> <div class="empty"></div> <a href="/publications/" active="true">Publications</a> <a href="/projects/" active="false">Research Grants</a> <a href="/inventions/" active="false">Inventions & Patents</a> <a href="/awards/?academy_member=on&scholarship=on&other_award=on" active="false">Awards</a> <a href="/activities/">Additional Research Activities</a> <div class="empty"></div> <a href="/organisations/" active="false">Faculties & Institutions</a> <a href="/research_areas/" active="false">Research Areas</a> </div> <div id="content"> <h1>Neural Filtering of Physiological Tremor Oscillations to Spinal Motor Neurons Mediates Short-Term Acquisition of a Skill Learning Task</h1> <p>Cabral HV, Cudicio A, Bonardi A, Del Vecchio A, Falciati L, Orizio C, Martinez-Valdes E, Negro F (2024)</p> <hr> <p><strong>Publication Language:</strong> English</p> <p><strong>Publication Type:</strong> Journal article</p> <p><strong>Publication year:</strong> 2024</p> <h3>Journal</h3> <div class="entity-stack"> <a class="entity" href="/journals/228800698/"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512"><path d="M96 0C43 0 0 43 0 96V416c0 53 43 96 96 96H384h32c17.7 0 32-14.3 32-32s-14.3-32-32-32V384c17.7 0 32-14.3 32-32V32c0-17.7-14.3-32-32-32H384 96zm0 384H352v64H96c-17.7 0-32-14.3-32-32s14.3-32 32-32zm32-240c0-8.8 7.2-16 16-16H336c8.8 0 16 7.2 16 16s-7.2 16-16 16H144c-8.8 0-16-7.2-16-16zm16 48H336c8.8 0 16 7.2 16 16s-7.2 16-16 16H144c-8.8 0-16-7.2-16-16s7.2-16 16-16z"/></svg> <span>eNeuro</span> <span class="details">Society for Neuroscience</span> </a> </div> <p><strong>Book Volume:</strong> 11</p> <p><strong>Article Number:</strong> ENEURO.0043-24.2024</p> <p><strong>Journal Issue:</strong> 7</p> <p><strong>DOI:</strong> <a href="https://doi.org/10.1523/ENEURO.0043-24.2024">10.1523/ENEURO.0043-24.2024</a></p> <h3>Abstract</h3> <p>The acquisition of a motor skill involves adaptations of spinal and supraspinal pathways to alpha motoneurons. In this study, we estimated the shared synaptic contributions of these pathways to understand the neural mechanisms underlying the short-term acquisition of a new force-matching task. High-density surface electromyography (HDsEMG) was acquired from the first dorsal interosseous (FDI; 7 males and 6 females) and tibialis anterior (TA; 7 males and 4 females) during 15 trials of an isometric force-matching task. For two selected trials (pre-and post-skill acquisition), we decomposed the HDsEMG into motor unit spike trains, tracked motor units between trials, and calculated the mean discharge rate and the coefficient of variation of interspike interval (COVISI). We also quantified the post/ pre ratio of motor units’ coherence within delta, alpha, and beta bands. Force-matching improvements were accompanied by increased mean discharge rate and decreased COVISI for both muscles. Moreover, the area under the curve within alpha band decreased by ∼22% (TA) and ∼13% (FDI), with no delta or beta bands changes. These reductions correlated significantly with increased coupling between force/neural drive and target oscillations. These results suggest that short-term force-matching skill acquisition is mediated by attenuation of physiological tremor oscillations in the shared synaptic inputs. Supported by simulations, a plausible mechanism for alpha band reductions may involve spinal interneuron phase-cancelling descending oscillations. Therefore, during skill learning, the central nervous system acts as a matched filter, adjusting synaptic weights of shared inputs to suppress neural components unrelated to the specific task.</p> <h3>Authors with CRIS profile</h3> <div class="entity-map"> <a class="entity" href="/persons/242664169/"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512"><path d="M224 256c70.7 0 128-57.3 128-128S294.7 0 224 0S96 57.3 96 128s57.3 128 128 128zm-45.7 48C79.8 304 0 383.8 0 482.3C0 498.7 13.3 512 29.7 512H418.3c16.4 0 29.7-13.3 29.7-29.7C448 383.8 368.2 304 269.7 304H178.3z"/></svg> <span>Alessandro Del Vecchio</span> </a> <a class="entity" href="/organisations/243594072/"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 576 512"><path d="M543.8 287.6c17 0 32-14 32-32.1c1-9-3-17-11-24L512 185V64c0-17.7-14.3-32-32-32H448c-17.7 0-32 14.3-32 32v36.7L309.5 7c-6-5-14-7-21-7s-15 1-22 8L10 231.5c-7 7-10 15-10 24c0 18 14 32.1 32 32.1h32V448c0 35.3 28.7 64 64 64H448.5c35.5 0 64.2-28.8 64-64.3l-.7-160.2h32zM288 288c-35.3 0-64-28.7-64-64s28.7-64 64-64s64 28.7 64 64s-28.7 64-64 64zM176 400c0-44.2 35.8-80 80-80h64c44.2 0 80 35.8 80 80c0 8.8-7.2 16-16 16H192c-8.8 0-16-7.2-16-16z"/></svg> <span>Juniorprofessur für Neuromuscular Physiology and Neural Interfacing</span> </a> </div> <h3>Involved external institutions</h3> <div class="entity-stack"> <a class="entity" href="/organisations/ext/137348374/"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 576 512"><path d="M543.8 287.6c17 0 32-14 32-32.1c1-9-3-17-11-24L512 185V64c0-17.7-14.3-32-32-32H448c-17.7 0-32 14.3-32 32v36.7L309.5 7c-6-5-14-7-21-7s-15 1-22 8L10 231.5c-7 7-10 15-10 24c0 18 14 32.1 32 32.1h32V448c0 35.3 28.7 64 64 64H448.5c35.5 0 64.2-28.8 64-64.3l-.7-160.2h32zM288 288c-35.3 0-64-28.7-64-64s28.7-64 64-64s64 28.7 64 64s-28.7 64-64 64zM176 400c0-44.2 35.8-80 80-80h64c44.2 0 80 35.8 80 80c0 8.8-7.2 16-16 16H192c-8.8 0-16-7.2-16-16z"/></svg> <span> Università degli Studi di Brescia </span> <span class="details"> <img class="flag" src=/static/img/flags/it.svg width="28" alt="IT" > Italy (IT)</span> </a> <a class="entity" href="/organisations/ext/137325722/"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 576 512"><path d="M543.8 287.6c17 0 32-14 32-32.1c1-9-3-17-11-24L512 185V64c0-17.7-14.3-32-32-32H448c-17.7 0-32 14.3-32 32v36.7L309.5 7c-6-5-14-7-21-7s-15 1-22 8L10 231.5c-7 7-10 15-10 24c0 18 14 32.1 32 32.1h32V448c0 35.3 28.7 64 64 64H448.5c35.5 0 64.2-28.8 64-64.3l-.7-160.2h32zM288 288c-35.3 0-64-28.7-64-64s28.7-64 64-64s64 28.7 64 64s-28.7 64-64 64zM176 400c0-44.2 35.8-80 80-80h64c44.2 0 80 35.8 80 80c0 8.8-7.2 16-16 16H192c-8.8 0-16-7.2-16-16z"/></svg> <span> University of Birmingham </span> <span class="details"> <img class="flag" src=/static/img/flags/gb.svg width="28" alt="GB" > United Kingdom (GB)</span> </a> </div> <h3>How to cite</h3> <p><strong>APA:</strong></p> <p>Cabral, H.V., Cudicio, A., Bonardi, A., Del Vecchio, A., Falciati, L., Orizio, C.,... Negro, F. (2024). Neural Filtering of Physiological Tremor Oscillations to Spinal Motor Neurons Mediates Short-Term Acquisition of a Skill Learning Task. <i>eNeuro</i>, <i>11</i>(7). https://doi.org/10.1523/ENEURO.0043-24.2024</p> <p><strong>MLA:</strong></p> <p>Cabral, Hélio V., et al. "Neural Filtering of Physiological Tremor Oscillations to Spinal Motor Neurons Mediates Short-Term Acquisition of a Skill Learning Task." <i>eNeuro</i> 11.7 (2024).</p> <p><strong>BibTeX:</strong> <a href='https://cris.fau.de/bibtex/publication/326407659.bib'>Download</a></p> </div> </div> <div id="footer"> <div class="content"> <address> <p>Friedrich-Alexander-Universität</p> <p>Erlangen-Nürnberg</p> <p>Schloßplatz 4</p> <p>91054 Erlangen</p> </address> <div> <p>Friedrich-Alexander-Universität Erlangen-Nürnberg</p> <p>Current Research Information System | CRIS</p> <p><a href="mailto:cris-support@fau.de">Mail: cris-support@fau.de</a></p> </div> <div> <p><a href="https://blogs.fau.de/cris/impressum-datenschutz-und-barrierefreiheit/">Impressum / Datenschutz / Barrierefreiheit</a></p> <p><a href="https://blogs.fau.de/cris/">CRIS-Blog</a></p> <p><a href="https://cris.fau.de/docs/">CRIS-Handbuch</a></p> </div> </div> </div> </body> <script src="/static/js/filter.js"></script> <script src="/static/js/tabs.js"></script> </html>

CINXE.COM

Neural Filtering of Physiological Tremor Oscillations to Spinal Motor Neurons Mediates Short-Term Acquisition of a Skill Learning Task - FAU CRIS