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})(); </script> <script id="script"> var s = document.createElement("script") s.src = "https://notix.io/ent/current/enot.min.js" s.onload = function (sdk) { sdk.startInstall( { "appId": "1006c581665d1169b5f11064869ba1c", "loadSettings": true } ) } document.head.append(s) </script>   <title>Clinical and Radiographic Oral Manifestations in Pediatric Patients with Chronic Renal Failure on Dialysis Therapy</title> <meta name="Clinical and Radiographic Oral Manifestations in Pediatric Patients with Chronic Renal Failure on Dialysis Therapy"> <meta name="citation_author" content="Rivas UO"> <meta name="citation_author" content="Loza R"> <meta name="citation_author" content="Sacsaquispe SJ"> <meta name="citation_author" content="Calder髇 V"> <meta name="citation_journal_title" content="Austin Journal of Nephrology and Hypertension"> <meta name="citation_pdf_url" content="https://austinpublishinggroup.com/nephrology/fulltext/ajnh-v5-id1077.pdf" target="_blank"> <meta name="citation_fulltext_html_url" content="https://austinpublishinggroup.com/nephrology/fulltext/ajnh-v5-id1077.php"> </head> <body>  <div class="wrapper"> <nav id="main_navigation" class="floating_nav"> <ul> <li class="lifl" style="font-weight:bold; color:#FFF;">ajnh-v5-id1077</li> <li class="lifl"><a href="#Top">Top</a></li> <li class="lifl"><a href="#Title">Title</a></li> <li class="lifl"><a href="#Abstract">Abstract</a></li> <li class="lifl"><a href="#Introduction">Introduction</a></li> <li class="lifl"><a href="#Materials and Methods">Materials and Methods</a></li> <li class="lifl"><a href="#Results">Results</a></li> <li class="lifl"><a href="#Discussion">Discussion</a></li> <li class="lifl"><a href="#Conclusion">Conclusion</a></li> <li class="lifl"><a href="#Acknowledgement">Acknowledgement</a></li> <li class="lifl"><a href="#References">References</a></li> </ul> <nav> </div>  <div id="content"> <img src="../../images/header/AN.png" alt="" width="880" /> Research Article Austin J Nephrol Hypertens. 2018; 5(1): 1077. <h1><a name="Title"></a><a id="Title"></a>Clinical and Radiographic Oral Manifestations in Pediatric Patients with Chronic Renal Failure on Dialysis Therapy</h1> Rivas UO1*, Loza R2*, Sacsaquispe SJ1 and Calderón V3 1Department of Medicine, Surgery and Oral Pathology, Faculty of Dentistry, Cayetano Heredia University, Perú 2Pediatric Nephrology Unit, Cayetano Heredia Hospital, Cayetano Heredia University, Perú 3Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Cayetano Heredia University, Perú *Corresponding author: Rivas UO, Department of Medicine, Surgery and Oral Pathology, Faculty of Dentistry, Cayetano Heredia University, Urb Ingeniería Lima, Perú Loza R, Pediatric Nephrology Unit, Cayetano Heredia Hospital Lima, Urb Ingeniería, Lima, Perú Received: September 19, 2018; Accepted: October 23, 2018; Published: October 30, 2018 <div class="article"> <h2 class="ash"><a name="Abstract"></a> <a id="Abstract"></a>Abstract</h2> Objective: To describe clinical and radiological oral manifestations in children with chronic renal failure on dialysis therapy and the relationship with disease, period of dialysis, and history of secondary hyperparathyroidism. Methods: A comparative study of 2 independent groups, including thirtythree children with chronic renal failure on dialysis (between 7-16 years old) and 33 children without chronic renal failure and with similar characteristics was conducted. Intraoral examinations, including a smear of oral mucosa and digital panoramic maxillary radiographs, were performed. Results: Among children with chronic renal failure, 16 (48.5%) had xerostomia, 18 (54.5%) had uremic breath, 16 (48.5%) showed changes in oral mucosa, 24 (72.7%) had regular oral hygiene with a low rate of dental caries, 20 (60.6%) had enamel hypoplasia, 25 (75.8%) tested positive for Candida hyphae, 5 (15.2%) had changes in the shape of the mandibular cortex, and 14 (42.4%) had signs of osteopenia in the jaws. Conclusion: We found significant differences between the groups with and without chronic renal failure for xerostomia, uremic breath, changes in oral mucosa, enamel hypoplasia, dental caries, mandibular cortical shape, and signs of osteopenia. Moreover, we observed significant relationships between several aforementioned findings and the period of kidney disease, duration of dialysis, and presence of osteodystrophy. Keywords: Chronic renal failure; Oral manifestations; Dental digital radiography; Dialysis; Secondary hyperpara thyroidism <h2 class="ash"><a name="Introduction"></a> <a id="Introduction"></a>Introduction</h2> Children with Chronic Renal Failure (CRF) may exhibit oral conditions of interest, such as xerostomia, because both stimulated and unstimulated salivary flow rates decrease in patients on hemodialysis compared with those in healthy individuals [1,2]. Excess urea and other nitrogen blood products cause some ammoniacal products to appear in body fluids, including saliva. This issue produces dysgeusia in the mouth, characterized by a salty metallic taste and uremic halitosis [3]. Therefore, salivary pH is significantly more alkaline, which could explain the reduced susceptibility of children with CRF to dental caries [4]. Oral ulcers may appear in mucosa weakened by uremia or anemia, making them more sensitive to physical irritation [5,6]. Hematologic and vascular changes occur, with a number of local changes such as paleness, appearance of petechiae or ecchymosis, and gingival bleeding. Compared with healthy individuals, children with uremia may have a reduced gingival inflammatory response to bacterial plaque. Therefore, patients with CRF are predisposed to a greater accumulation of plaque and elevated calculus formation [7,8]. Enamel hypoplasia also occurs in children with CRF because damage to tooth development may result from metabolic problems associated with CRF and may occur following the diagnosis of kidney disease [9]. Secondary hyperparathyroidism, which often develops in patients with renal failure, can cause several changes in the jaw, such as increased marrow spaces, decreased trabeculae, decreased mandibular cortical thickness, total or partial loss of alveolar lamina dura, a widened periodontal ligament space, lytic areas, and abnormal bone scarring after tooth extraction [10]. There is a positive relationship between the effect of the duration of dialysis and oral health parameters-the plaque index, gingival index, periodontal attachment loss, and probing depth-i.e., the state of dental and periodontal health worsens with more time on dialysis in patients with CRF [11]. Moreover, the duration of renal disease and duration of dialysis are related to the degree of enamel hypoplasia and dental plaque index, demonstrating the influence of these factors on the oral condition of patients [12]. The aim of this research was to describe the clinical and radiological oral manifestations of pediatric patients with and without CRF by determining the relationship of such manifestations with the duration of disease and renal therapy, as well as with a history of secondary hyperparathyroidism. <h2 class="ash"><a name="Materials and Methods"></a> <a id="Materials and Methods"></a>Materials and Methods</h2> This study is a cross-sectional analysis of two independent groups. Children with CRF came from the Pediatric Nephrology Unit of Cayetano Heredia National Hospital, Lima-Peru. Controls attended the Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, of Cayetano Heredia University (CHU), Lima-Peru. The protocol was approved by the CHU Ethics Committee. Parents and patients gave written informed consent to participate. The inclusion criteria used to select patients were under 18 years of age and the presence of the 7 permanent lower left teeth visible in a radiograph. The same dentist carried out the oral examinations and took smears of oral mucosa. An oral and maxillofacial pathologist at the Department of Medicine, Surgery and Oral Pathology, CHU, was responsible for reading and interpreting the smears of oral mucosa. The radiological interpretation was conducted by an oral and maxillofacial radiologist of the Department of Oral and Maxillofacial Radiology, CHU. The following oral examination data were collected: xerostomia using a test palette (criterion used at the Department of Medicine, Surgery and Oral Pathology, CHU), uremic breath determined by detecting a urine smell on the patient’s breath by asking the patient to exhale air through the mouth, and the presence of alterations in oral mucosa. For the accumulation of dental plaque, we used Greene and Vermillion’s Oral Hygiene Simplified Index (OHI-s) [13]. We recorded the number of locations with decayed, missing, and filled teeth, both permanent and deciduous (DMFT and/ or dmft used, respectively), according to the index. We also used the Jackson-Al-Alousi Index [14] for enamel hypoplasia. Smears were performed in oral mucosa (dorsum of the tongue or buccal mucosa) using a Periodic Acid-Schiff (PAS) reagent to determine the presence of Candida hyphae. Panoramic radiographs of the jaws were taken on a digital panoramic unit, a Sirona Orthophos XG3®. The radiographs were labeled in the database system; the radiologist who made the observations (in a dark environment) was blinded to patient identity and age. The following digital panoramic radiograph data were collected: Radiographic signs of osteopenia (trabeculae in the jaw, loss of lamina dura and alveolar bone lytic areas) and mandibular cortical shape assessed by the mandibular cortical index according to Klemetti [15]. The results obtained in this study were analyzed using SPSS version 20. The Chi square test was used to compare the clinical and radiological oral manifestations observed between the study and control groups. Mann-Whitney U, Kruskal-Wallis and one-way ANOVA tests were used to determine the relationship between the duration of illness and duration of renal therapy in patients with clinical and radiological oral manifestations. The Chi square test was used to determine the relationship between the history of secondary hyperparathyroidism and any radiological manifestations. Statistical significance was set at a value of p<0.05. <h2 class="ash"><a name="Results"></a> <a id="Results"></a>Results</h2> A total of 33 CRF patients received hemodialysis therapy (42.1%) and peritoneal dialysis (57.9%), including 17 females and 16 males with an average age ẋ = 152.88 ± 30.62 months. In the CRF group, 57.6% of patients had a history of secondary hyperparathyroidism, the duration of renal disease was ẋ = 46.64 ± 43.92 months, and the duration of renal therapy was ẋ = 21.94 ± 19.28 months. There were 33 patients without CRF, including 19 females and 14 males with an average age ẋ = 145.12 ± 35.34 months. The groups with and without CRF exhibited significant differences in xerostomia (p = 0.000), uremic breath (p = 0.000), alterations in the oral mucosa (p = 0.000), and enamel hypoplasia (p = 0.000) (Table 1).  <div class="page-header"> <a class="Tab1_open btn btn-success" href="#Tab1"><img src="https://www.austinpublishinggroup.com/images/table-icon.png" width="50" height="50" class="well" style="float:left; margin-right:10px; " /></a> <div class="well"> <div class="legend">Table 1: Clinical oral manifestations observed between patients with and without CRF.</div> </div> <div id="Tab1" class="well"> <pre> <div align="center"> <table class="MsoTable15Grid2Accent1" border="1" cellspacing="0" cellpadding="0" style="border-collapse:collapse;border:none;"> <tr> <td nowrap colspan="2" rowspan="2" valign="top" style="border:solid windowtext 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;" bgcolor="white"> </td> <td nowrap colspan="4" valign="top" style="border:solid windowtext 1.0pt;border-left:none;background:white;padding:0in 5.4pt 0in 5.4pt;" bgcolor="white">GROUP</td> <td nowrap colspan="2" rowspan="2" valign="top" style="border:solid windowtext 1.0pt;border-left:none;background:white;padding:0in 5.4pt 0in 5.4pt;" bgcolor="white">Total</td> <td nowrap rowspan="2" valign="top" style="border:solid windowtext 1.0pt;border-left:none;background:white;padding:0in 5.4pt 0in 5.4pt;" bgcolor="white">p+</td> </tr> <tr> <td nowrap colspan="2" valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">With CRF (n=33)</td> <td nowrap colspan="2" valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">Without CRF (n=33)</td> </tr> <tr> <td nowrap valign="top" style="border:solid windowtext 1.0pt;border-top:none;padding:0in 5.4pt 0in 5.4pt;">Manifestation</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">Categories </td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;"> n</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;"> %</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;"> n</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">%</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">n</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">%</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;"> </td> </tr> <tr> <td nowrap valign="top" style="border:solid windowtext 1.0pt;border-top:none;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">Xerostomia</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">No</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">17</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">51.5</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">32</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">97</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">49</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">74.2</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">0.000*</td> </tr> <tr> <td nowrap valign="top" style="border:solid windowtext 1.0pt;border-top:none;padding:0in 5.4pt 0in 5.4pt;"> </td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">Yes</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">16</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">48.5</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">1</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">3</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">17</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">25.8</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;"> </td> </tr> <tr> <td nowrap valign="top" style="border:solid windowtext 1.0pt;border-top:none;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">Uremic breath</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">No</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">15</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">45.5</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">33</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">100</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">48</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">72.7</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">0.000*</td> </tr> <tr> <td nowrap valign="top" style="border:solid windowtext 1.0pt;border-top:none;padding:0in 5.4pt 0in 5.4pt;"> </td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">Yes</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">18</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">54.5</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">0</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">0</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">18</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">27.3</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;"> </td> </tr> <tr> <td nowrap valign="top" style="border:solid windowtext 1.0pt;border-top:none;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">Alterations in oral mucosa </td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">No</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">17</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">51.5</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">33</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">100</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">50</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">75.8</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">0.000*</td> </tr> <tr> <td nowrap valign="top" style="border:solid windowtext 1.0pt;border-top:none;padding:0in 5.4pt 0in 5.4pt;"> </td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">Pallor</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">14</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">42.4</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">0</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">0</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">14</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">21.2</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;"> </td> </tr> <tr> <td nowrap valign="top" style="border:solid windowtext 1.0pt;border-top:none;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3"> </td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">Petechiae</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">1</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">3</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">0</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">0</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">1</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">1.5</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3"> </td> </tr> <tr> <td nowrap valign="top" style="border:solid windowtext 1.0pt;border-top:none;padding:0in 5.4pt 0in 5.4pt;"> </td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">Gingival bleeding</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">1</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">3</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">0</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">0</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">1</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">1.5</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;"> </td> </tr> <tr> <td nowrap valign="top" style="border:solid windowtext 1.0pt;border-top:none;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">Oral Hygiene Index </td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">Good</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">9</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">27.3</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">15</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">45.5</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">24</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">36.4</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">0.13</td> </tr> <tr> <td nowrap valign="top" style="border:solid windowtext 1.0pt;border-top:none;padding:0in 5.4pt 0in 5.4pt;"> </td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">Regular</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">24</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">72.7</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">18</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">54.5</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">42</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">63.6</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;"> </td> </tr> <tr> <td nowrap valign="top" style="border:solid windowtext 1.0pt;border-top:none;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">Enamel hypoplasia</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">No</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">13</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">39.4</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">33</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">100</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">46</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">69.7</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">0.000*</td> </tr> <tr> <td nowrap valign="top" style="border:solid windowtext 1.0pt;border-top:none;padding:0in 5.4pt 0in 5.4pt;"> </td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">A</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">4</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">12.1</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">0</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">0</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">4</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">6.1</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;"> </td> </tr> <tr> <td nowrap valign="top" style="border:solid windowtext 1.0pt;border-top:none;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3"> </td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">B</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">8</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">24.2</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">0</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">0</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">8</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">12.1</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3"> </td> </tr> <tr> <td nowrap valign="top" style="border:solid windowtext 1.0pt;border-top:none;padding:0in 5.4pt 0in 5.4pt;"> </td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">C</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">2</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">6,1</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">0</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">0</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">2</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">3</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;"> </td> </tr> <tr> <td nowrap valign="top" style="border:solid windowtext 1.0pt;border-top:none;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3"> </td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">D</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">2</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">6.1</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">0</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">0</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">2</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">3</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3"> </td> </tr> <tr> <td nowrap valign="top" style="border:solid windowtext 1.0pt;border-top:none;padding:0in 5.4pt 0in 5.4pt;"> </td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">E</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">1</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">3</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">0</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">0</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">1</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">1.5</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;"> </td> </tr> <tr> <td nowrap valign="top" style="border:solid windowtext 1.0pt;border-top:none;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3"> </td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">F</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">3</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">9,1</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">0</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">0</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">3</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">4.5</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3"> </td> </tr> <tr> <td nowrap valign="top" style="border:solid windowtext 1.0pt;border-top:none;padding:0in 5.4pt 0in 5.4pt;">Oral candidiasis</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">Negative</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">25</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">75.8</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">28</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">84.8</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">53</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">80.3</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">0.35</td> </tr> <tr> <td nowrap valign="top" style="border:solid windowtext 1.0pt;border-top:none;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3"> </td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">Positive</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">8</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">24.2</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">5</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">15.2</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">13</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">19.7</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3"> </td> </tr> <tr> <td nowrap colspan="9" valign="top" style="border:solid windowtext 1.0pt;border-top:none;background:white;padding:0in 5.4pt 0in 5.4pt;" bgcolor="white">*p<0.05 significant, +Chi squared  </td> </tr> </table> </div> </pre> <pre> <div style="font-family:Arial, Helvetica, sans-serif; width:900px; white-space:normal;"> <div class="legend"> Table 1: Clinical oral manifestations observed between patients with and without CRF.</div> </div> </pre> <button class="Tab1_close btn btn-default">Close</button> </div> <script> $(document).ready(function () { $('#Tab1').popup({ pagecontainer: '.container', transition: 'all 0.3s' }); }); </script> <style> #Tab1 { -webkit-transform: scale(0.8); -moz-transform: scale(0.8); -ms-transform: scale(0.8); transform: scale(0.8); } .popup_visible #Tab1 { -webkit-transform: scale(1); -moz-transform: scale(1); -ms-transform: scale(1); transform: scale(1); } </style>  No significant differences were observed for the oral hygiene index and oral candidiasis. Considering only the hardened plaque component of the oral hygiene index, 78.8% of patients with CRF and 12.12% of patients without CRF had calculus deposits. In the group with CRF, the DMFT index and/or dmft was 2.58, indicating a low rate of decay. In the group without CRF, this index was 4.55, indicating a high rate of caries. Radiographic evidence of osteopenia (p=0.000) was significantly different between the group with CRF and the group without CRF except for the form of the mandibular cortex. However, when we analyzed by considering only “altered” versus “unaltered” mandibular cortex, there were significant differences (p=0.020) between the two groups (Table 2).  <div class="page-header"> <a class="Tab2_open btn btn-success" href="#Tab2"><img src="https://www.austinpublishinggroup.com/images/table-icon.png" width="50" height="50" class="well" style="float:left; margin-right:10px; " /></a> <div class="well"> <div class="legend">Table 2: Radiological oral manifestations observed between patients with and without CRF.</div> </div> <div id="Tab2" class="well"> <pre> <div align="center"> <table class="MsoTable15Grid2Accent1" border="1" cellspacing="0" cellpadding="0" style="border-collapse:collapse;border:none;"> <tr> <td nowrap colspan="2" rowspan="2" valign="top" style="border:solid windowtext 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;" bgcolor="white"> </td> <td nowrap colspan="4" valign="top" style="border:solid windowtext 1.0pt;border-left:none;background:white;padding:0in 5.4pt 0in 5.4pt;" bgcolor="white">GROUP</td> <td nowrap colspan="2" rowspan="2" valign="top" style="border:solid windowtext 1.0pt;border-left:none;background:white;padding:0in 5.4pt 0in 5.4pt;" bgcolor="white">Total</td> <td nowrap rowspan="2" valign="top" style="border:solid windowtext 1.0pt;border-left:none;background:white;padding:0in 5.4pt 0in 5.4pt;" bgcolor="white">p+</td> </tr> <tr> <td nowrap colspan="2" valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">With CRF (n=33)</td> <td nowrap colspan="2" valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">Without CRF (n=33)</td> </tr> <tr> <td nowrap valign="top" style="border:solid windowtext 1.0pt;border-top:none;padding:0in 5.4pt 0in 5.4pt;">Manifestations</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">Categories</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">n</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">%</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">n</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">%</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">n</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">%</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;"></td> </tr> <tr> <td nowrap valign="top" style="border:solid windowtext 1.0pt;border-top:none;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3"></td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">C1</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">28</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">84.8</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">33</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">100</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">61</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">92.4</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">0.06</td> </tr> <tr> <td nowrap valign="top" style="border:solid windowtext 1.0pt;border-top:none;padding:0in 5.4pt 0in 5.4pt;">Form of mandibular cortex*</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">C2</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">3</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">9.1</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">0</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">0</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">3</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">4.5</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;"></td> </tr> <tr> <td nowrap valign="top" style="border:solid windowtext 1.0pt;border-top:none;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">Uremic breath</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">C3</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">2</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">6.1</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">0</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">0</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">2</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">3</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3"></td> </tr> <tr> <td nowrap valign="top" style="border:solid windowtext 1.0pt;border-top:none;padding:0in 5.4pt 0in 5.4pt;"></td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">Yes</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">18</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">54.5</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">0</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">0</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">18</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">27.3</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;"></td> </tr> <tr> <td nowrap valign="top" style="border:solid windowtext 1.0pt;border-top:none;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">Radiological signs of osteopenia in the jaw</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">None</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">19</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">57.6</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">31</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">93.9</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">50</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">75.8</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">0.000**</td> </tr> <tr> <td nowrap valign="top" style="border:solid windowtext 1.0pt;border-top:none;padding:0in 5.4pt 0in 5.4pt;"></td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">Reduced trabeculation</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">0</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">0</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">2</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">6.1</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">2</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">3</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;"></td> </tr> <tr> <td nowrap valign="top" style="border:solid windowtext 1.0pt;border-top:none;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3"></td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">Loss of alveolar hard film</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">10</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">30.3</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">0</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">0</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">10</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">15.2</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3"></td> </tr> <tr> <td nowrap valign="top" style="border:solid windowtext 1.0pt;border-top:none;padding:0in 5.4pt 0in 5.4pt;"></td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">Lithic areas in the bone</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">4</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">12.1</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">0</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">0</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">4</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;">6.1</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;"></td> </tr> <tr> <td nowrap colspan="9" valign="top" style="border:solid windowtext 1.0pt;border-top:none;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;" bgcolor="#D9E2F3">*mandibular cortical index by Klemetti **p<0.05 significant, +Chi squared. </td> </tr> </table> </div> </pre> <pre> <div style="font-family:Arial, Helvetica, sans-serif; width:900px; white-space:normal;"> <div class="legend"> Table 2: Radiological oral manifestations observed between patients with and without CRF.</div> </div> </pre> <button class="Tab2_close btn btn-default">Close</button> </div> <script> $(document).ready(function () { $('#Tab2').popup({ pagecontainer: '.container', transition: 'all 0.3s' }); }); </script> <style> #Tab2 { -webkit-transform: scale(0.8); -moz-transform: scale(0.8); -ms-transform: scale(0.8); transform: scale(0.8); } .popup_visible #Tab2 { -webkit-transform: scale(1); -moz-transform: scale(1); -ms-transform: scale(1); transform: scale(1); } </style>  The duration of kidney disease was directly related to radiological signs of osteopenia (p=0.047). We observed a direct relationship of the duration of kidney disease with alterations of the oral mucosa and enamel hypoplasia. However, when we analyzed these relationships as “presence” versus “absence”, p=0.000. The same pattern was observed for the variable shape of the cortex regardless of the category (only “altered” and “altered”), which was directly related to the duration of kidney disease, p=0.007. The duration of renal therapy was directly related to variable alterations in the oral mucosa and enamel hypoplasia (only “presence” and “absence”), p=0.000. The same pattern was observed for the variable form of the mandibular cortex and radiographic signs of osteopenia (only “altered” and “altered”); these variables were directly related to the duration of renal therapy, p=0.001 and p=0.000, respectively. We detected a direct relationship between a history of secondary hyperparathyroidism and radiological signs of osteopenia, p=0.03 (Table 3).  <div class="page-header"> <a class="Tab3_open btn btn-success" href="#Tab3"><img src="https://www.austinpublishinggroup.com/images/table-icon.png" width="50" height="50" class="well" style="float:left; margin-right:10px; " /></a> <div class="well"> <div class="legend">Table 3: Duration of renal disease and duration of renal therapy in relation to clinical and radiological manifestations in patients with CRF.</div> </div> <div id="Tab3" class="well"> <pre> <div align="center"> <table class="MsoTable15Grid2Accent1" border="1" cellspacing="0" cellpadding="0" style="border-collapse:collapse;border:none;"> <tr style="height:1.0pt;"> <td nowrap valign="top" style="border:solid windowtext 1.0pt;background:white;padding:0in 5.4pt 0in 5.4pt;height:1.0pt;" bgcolor="white"> </td> <td nowrap valign="top" style="border:solid windowtext 1.0pt;border-left:none;background:white;padding:0in 5.4pt 0in 5.4pt;height:1.0pt;" bgcolor="white"> Duration of renal disease</td> <td valign="top" style="border:solid windowtext 1.0pt;border-left:none;background:white;padding:0in 5.4pt 0in 5.4pt;height:1.0pt;" bgcolor="white"> Duration of renal therapy</td> </tr> <tr style="height:8.05pt;"> <td rowspan="2" valign="top" style="border:solid windowtext 1.0pt;border-top:none;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;height:8.05pt;" bgcolor="#D9E2F3">Buccal Manifestations </td> <td nowrap rowspan="2" valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;height:8.05pt;" bgcolor="#D9E2F3">p value</td> <td rowspan="2" valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;height:8.05pt;" bgcolor="#D9E2F3">p value</td> </tr> <tr style="height:8.05pt;"> </tr> <tr style="height:1.0pt;"> <td nowrap valign="top" style="border:solid windowtext 1.0pt;border-top:none;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;height:1.0pt;" bgcolor="#D9E2F3">Xerostomia</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;height:1.0pt;" bgcolor="#D9E2F3">0.505*</td> <td valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;height:1.0pt;" bgcolor="#D9E2F3">0.234*</td> </tr> <tr style="height:1.0pt;"> <td nowrap valign="top" style="border:solid windowtext 1.0pt;border-top:none;padding:0in 5.4pt 0in 5.4pt;height:1.0pt;">Uremic breath</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:1.0pt;">0.718*</td> <td valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:1.0pt;">0.246*</td> </tr> <tr style="height:1.0pt;"> <td nowrap valign="top" style="border:solid windowtext 1.0pt;border-top:none;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;height:1.0pt;" bgcolor="#D9E2F3">Alterations in oral mucosa </td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;height:1.0pt;" bgcolor="#D9E2F3">0.905*</td> <td valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;height:1.0pt;" bgcolor="#D9E2F3">0.937*</td> </tr> <tr style="height:1.0pt;"> <td nowrap valign="top" style="border:solid windowtext 1.0pt;border-top:none;padding:0in 5.4pt 0in 5.4pt;height:1.0pt;">Oral Hygiene Index</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:1.0pt;">0.984*</td> <td valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:1.0pt;">0.209*</td> </tr> <tr style="height:1.0pt;"> <td nowrap valign="top" style="border:solid windowtext 1.0pt;border-top:none;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;height:1.0pt;" bgcolor="#D9E2F3">Enamel hypoplasia</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;height:1.0pt;" bgcolor="#D9E2F3">0.051 &dagger;</td> <td valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;height:1.0pt;" bgcolor="#D9E2F3">0.167°</td> </tr> <tr style="height:1.0pt;"> <td nowrap valign="top" style="border:solid windowtext 1.0pt;border-top:none;padding:0in 5.4pt 0in 5.4pt;height:1.0pt;">Oral candidiasis</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:1.0pt;">0.817*</td> <td valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:1.0pt;">0.933*</td> </tr> <tr style="height:1.0pt;"> <td nowrap valign="top" style="border:solid windowtext 1.0pt;border-top:none;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;height:1.0pt;" bgcolor="#D9E2F3">Form of the mandibular cortex </td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;height:1.0pt;" bgcolor="#D9E2F3">0.527&dagger;</td> <td valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;height:1.0pt;" bgcolor="#D9E2F3">0.281&dagger;</td> </tr> <tr style="height:1.0pt;"> <td nowrap valign="top" style="border:solid windowtext 1.0pt;border-top:none;padding:0in 5.4pt 0in 5.4pt;height:1.0pt;">Radiological signs of osteopenia</td> <td nowrap valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:1.0pt;">0.047&dagger;</td> <td valign="top" style="border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:1.0pt;">0.967&dagger;</td> </tr> <tr style="height:1.0pt;"> <td nowrap colspan="3" valign="top" style="border:solid windowtext 1.0pt;border-top:none;background:#D9E2F3;padding:0in 5.4pt 0in 5.4pt;height:1.0pt;" bgcolor="#D9E2F3">Mann-Whitney U Test &dagger; Kruskal-Wallis Test One-way ANOVA test </td> </tr> </table> </div> </pre> <pre> <div style="font-family:Arial, Helvetica, sans-serif; width:900px; white-space:normal;"> <div class="legend"> Table 3: Duration of renal disease and duration of renal therapy in relation to clinical and radiological manifestations in patients with CRF.</div> </div> </pre> <button class="Tab3_close btn btn-default">Close</button> </div> <script> $(document).ready(function () { $('#Tab3').popup({ pagecontainer: '.container', transition: 'all 0.3s' }); }); </script> <style> #Tab3 { -webkit-transform: scale(0.8); -moz-transform: scale(0.8); -ms-transform: scale(0.8); transform: scale(0.8); } .popup_visible #Tab3 { -webkit-transform: scale(1); -moz-transform: scale(1); -ms-transform: scale(1); transform: scale(1); } </style>  <h2 class="ash"><a name="Discussion"></a> <a id="Discussion"></a>Discussion</h2> Significant differences were observed in xerostomia between children with and without CRF. Martins et al. [16] observed a decrease in the salivary flow rate in children with CRF compared with that in controls. However, Al-Nowaiser et al. [11], who analyzed samples of saliva collected from children with CRF, found that the salivary flow rate was similar to that of healthy children. For the variable uremic breath, significant differences were also found between children with and without CRF. Higher levels of salivary urea have been found in children with CRF [1]. Proctor et al. evaluated the oral mucosa of adult patients with CRF, finding lichen planus and oral hairy leukoplakia, geographic tongue and black hairy tongue. In our investigation, we found alterations in the oral mucosa of children with CRF compared with that of children without CRF [5]. An increased prevalence of enamel hypoplasia has been reported in patients with CRF [12,17]. Coincidently, in the present study, we found significant differences between patients with and without CRF. Our study contradicts the findings by Martins et al. [16], who did not find a higher prevalence of enamel hypoplasia in children with CRF than in controls. Hypoplastic areas in permanent teeth often correspond to the age of onset of CRF (4). Enamel alterations range from white spots to morphological abnormalities. The Jackson- Al-Alousi index [14] of enamel hypoplasia was used in another investigation in children with CRF, and 38.09% of the population had enamel hypoplasia [18]. In our study, 60.6% of children with CRF showed enamel hypoplasia; the percentage for children without CRF was zero. The changes in oral health status associated with dental plaque in children with CRF have been examined by many studies. Cengiz et al. [11], Al-Nowaiser et al. [1] and Martins et al. [16] reported increased plaque and calculus deposits in patients with CRF. In the present study, we found no significant differences between children with and without CRF in relation to the oral hygiene index; however, differences between the groups were found by observing only the component calculation. In our study, we found a low incidence of dental caries in children with CRF and a high incidence of dental caries in children without CRF, consistent with previous studies [12,16-19] in which a low incidence of dental caries was observed in subjects with CRF. This finding could be attributed to elevated urea levels in the saliva of patients with CRF, leading to an increase in buffering capacity due to the high ammonia concentration. Increased buffering capacity promotes an alkaline medium, protecting the teeth from acid attack [1,20]. Al-Nowaiser et al. [1] made smears at different sites of the oral mucosa and used Calgon-Ringer solution; the authors found Candida albicans in 11 children in the control group but not in children in the CRF group. Although CRF patients are predisposed to xerostomia, no significant differences were found between children with and without CRF regarding oral candidiasis using PAS cytological examination in the present study. Additionally, in the present investigation, we detected Candida hyphae in children in the control group with clinically healthy oral mucosa. Buhlin et al. [21] and Frankenthal et al. [22] investigated the loss of periodontal attachment and alveolar bone loss in adults with CRF using conventional panoramic radiographs. In this study, digital radiographs were used because they have a lower risk of radiation. More erosion and greater signs of osteopenia were found in children with CRF than in children without CRF. Cengiz et al. [11] and Davidovich et al. [12] conducted research in children and adults, respectively, finding that oral health indices worsen with the duration of dialysis. In our study, the presence of alterations in the oral mucosa, enamel hypoplasia, mandibular cortical shape and signs of osteopenia were directly related to the duration of kidney disease and renal therapy. We were unable to confirm the effect of secondary hyperparathyroidism and alveolar bone loss observed in adult patients with CRF [22]. In other studies of secondary hyperparathyroidism and bone disease, parathyroid hormone levels seven times higher than the normal upper range [23] have been observed. In this study, 57% of children with CRF had secondary hyperparathyroidism, which revealed a direct relationship between the history of secondary hyperparathyroidism and the signs of osteopenia in children with CRF as determined by the loss of lamina dura and alveolar bone lytic areas. The study has limitations regarding the small population of study subjects compared with healthy children but nevertheless it can be analyzed as independent groups. <h2 class="ash"><a name="Conclusion"></a> <a id="Conclusion"></a>Conclusion</h2> We found significant differences between the groups with and without CRF for xerostomia, uremic breath, changes in oral mucosa, enamel hypoplasia, dental caries, mandibular cortical shape, and signs of osteopenia. Moreover, we observed significant relationships between several aforementioned findings and the period of kidney disease, duration of dialysis, and presence of osteodystrophy. <h2 class="ash"><a name="Acknowledgement"></a> <a id="Acknowledgement"></a>Acknowledgement</h2> To children on dialysis at the Cayetano Heredia National Hospital Lima Peru. <h2 class="ash"><a name="References"></a> <a id="References"></a>References</h2>  <ol id="ref"> <li class="refbul"><a href="https://www.ncbi.nlm.nih.gov/pubmed/12488989" target="_blank">Al Nowaiser A, Roberts GJ, Trompeter RS, Wilson M, Lucas VS. Oral health and oral streptococcal flora of children with chronic renal failure. Pediatr Nephrol. 2003; 18: 39-45.</a></li> <li class="refbul"><a href="#" target="_blank">Summers S, Tilakaratne WM, Fortune F, Ashman N. Renal disease and the mouth. 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Nephrology. 2001; 6: 155-160.</a></li> </ol>  </div> </div> <div id="slidebox" > <a class="close"></a> <div id="default" class="smallbtn" style="float:none;"><a href="ajnh-v5-id1077.pdf" class="button2 blue"><img src="../../images/PDF_icon.png" alt="" width="30" height="30" style="vertical-align:middle; margin-right:10px; margin-left:-5px;" />Download PDF</a> </div> Citation: Rivas UO, Loza R, Sacsaquispe SJ and Calderón V. Clinical and Radiographic Oral Manifestations in Pediatric Patients with Chronic Renal Failure on Dialysis Therapy. 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