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<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "DTD/xhtml1-transitional.dtd"> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <meta http-equiv="Content-Type" content="text/html; charset=UTF-8"/> <meta http-equiv="expires" content="43200"/>   <title>mediaTUM - Medien- und Publikationsserver</title> <meta name="generator" content="mediatum - a multimedia content repository"/> <link rel="icon" type="image/vnd.microsoft.icon" href="/favicon.ico"/> <link rel="apple-touch-icon" sizes="57x57" href="/apple-touch-icon-57x57.png"/> <link rel="apple-touch-icon" sizes="60x60" href="/apple-touch-icon-60x60.png"/> <link rel="apple-touch-icon" sizes="72x72" href="/apple-touch-icon-72x72.png"/> <link rel="apple-touch-icon" sizes="76x76" href="/apple-touch-icon-76x76.png"/> <link rel="apple-touch-icon" sizes="114x114" href="/apple-touch-icon-114x114.png"/> <link rel="apple-touch-icon" sizes="120x120" href="/apple-touch-icon-120x120.png"/> <link rel="apple-touch-icon" sizes="144x144" href="/apple-touch-icon-144x144.png"/> <link rel="apple-touch-icon" sizes="152x152" href="/apple-touch-icon-152x152.png"/> <link rel="apple-touch-icon" sizes="180x180" href="/apple-touch-icon-180x180.png"/> <link rel="icon" type="image/png" href="/favicon-32x32.png" sizes="32x32"/> <link rel="icon" type="image/png" href="/favicon-194x194.png" sizes="194x194"/> <link rel="icon" type="image/png" href="/favicon-96x96.png" sizes="96x96"/> <link rel="icon" type="image/png" href="/android-chrome-192x192.png" sizes="192x192"/> <link rel="icon" type="image/png" href="/favicon-16x16.png" sizes="16x16"/> <meta name="msapplication-TileColor" content="#ffffff"/> <meta name="msapplication-TileImage" content="/mstile-144x144.png"/> <meta name="theme-color" content="#ffffff"/> <link rel="stylesheet" href="/static/css/mediatum.css"/> <script src="/static/js/mediatum.js"></script> <script src="/static/js/jquery-1.12.4.js"></script> <script type="text/javascript" language="javascript">function change_size(){ var searchform = $('#search-form').height(); var cheight = $('#portal-column-content').height()+12; $('#frame-tree').height(cheight-searchform); } $(window).resize(function() { change_size(); }); </script> <meta name="citation_author" content="Dinter, Juliane"/> <meta name="citation_author" content="M眉hlhaus, Jessica"/> <meta name="citation_author" content="Wienchol, Carolin Leonie"/> <meta name="citation_author" content="Yi, Chun-Xia"/> <meta name="citation_author" content="N眉rnberg, Daniela"/> <meta name="citation_author" content="Morin, Silke"/> <meta name="citation_author" content="Gr眉ters, Annette"/> <meta name="citation_author" content="K枚hrle, Josef"/> <meta name="citation_author" content="Sch枚neberg, Torsten"/> <meta name="citation_author" content="Tsch枚p, Matthias"/> <meta name="citation_author" content="Krude, Heiko"/> <meta name="citation_author" content="Kleinau, Gunnar"/> <meta name="citation_author" content="Biebermann, Heike"/> <meta name="citation_title" content="Inverse agonistic action of 3-iodothyronamine at the human trace amine-associated receptor 5."/> <meta name="citation_issue" content="2"/> <meta name="citation_volume" content="10"/> <meta name="citation_issn" content="1932-6203"/> <meta name="citation_doi" content="10.1371/journal.pone.0117774"/> <meta name="citation_firstpage" content="e0117774"/> <meta name="citation_publication_date" content="2015"/> <meta name="DC.description" content="Application of 3-iodothyronamine (3-T1AM) results in decreased body temperature and body weight in rodents. The trace amine-associated receptor (TAAR) 1, a family A G protein-coupled receptor, is a target of 3-T1AM. However, 3-T1AM effects still persist in mTaar1 knockout mice, which suggest so far unknown further receptor targets that are of physiological relevance. TAAR5 is a highly conserved TAAR subtype among mammals and we here tested TAAR5 as a potential 3-T1AM target. First, we investigated mouse Taar5 (mTaar5) expression in several brain regions of the mouse in comparison to mTaar1. Secondly, to unravel the full spectrum of signaling capacities, we examined the distinct Gs-, Gi/o-, G12/13-, Gq/11- and MAP kinase-mediated signaling pathways of mouse and human TAAR5 under ligand-independent conditions and after application of 3-T1AM. We found overlapping localization of mTaar1 and mTaar5 in the amygdala and ventromedial hypothalamus of the mouse brain. Second, the murine and human TAAR5 (hTAAR5) display significant basal activity in the Gq/11 pathway but show differences in the basal activity in Gs and MAP kinase signaling. In contrast to mTaar5, 3-T1AM application at hTAAR5 resulted in significant reduction in basal IP3 formation and MAP kinase signaling. In conclusion, our data suggest that the human TAAR5 is a target for 3-T1AM, exhibiting inhibitory effects on IP3 formation and MAP kinase signaling pathways, but does not mediate Gs signaling effects as observed for TAAR1. This study also indicates differences between TAAR5 orthologs with respect to their signaling profile. In consequence, 3-T1AM-mediated effects may differ between rodents and humans."/> <link rel="stylesheet" href="/static/css/mediatum-tum-editor.css"/> </head> <body onload="change_size();"> <div id="visual-portal-wrapper"> <div id="portal-top"> <div class="header header-left"> <script type="application/javascript" src="/static/js/webstat.js"></script> <noscript> <p><img src="https://webstat.srv.tum.de/matomo.php?idsite=78&rec=1" style="border:0;" alt="Matomo Image Tracker"/> </p> </noscript> <ul> <li><a href="/" class="mediatum-link-internal">mediaTUM</a> </li> <li><a href="https://www.ub.tum.de" class="mediatum-link-external">Universit盲tsbibliothek</a> </li> <li><a href="https://www.tum.de" class="mediatum-link-external">Technische Universit盲t M眉nchen</a> </li> </ul> </div> <div class="header header-right"><a href="https://tum.de" title="Home tum.de" class="header-logo"><img src="/static/img/logo_tum.png" alt="Logo" width="73" height="38"/></a> </div> </div> <div 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</tr> </table><br/> </div>  <link rel="stylesheet" href="/static/css/childs.css"/> <link rel="stylesheet" href="/static/css/jade_style.css"/> <div class="object_main content_container"> <dl class="object_meta object_column"><dt class="mask_label">Titel:</dt> <dd class="mask_value"><h1>Inverse agonistic action of 3-iodothyronamine at the human trace amine-associated receptor 5.</h1></dd> <dt class="mask_label">Dokumenttyp:</dt> <dd class="mask_value">Journal Article; Research Support, Non-U.S. Gov't; Article</dd> <dt class="mask_label">Autor(en):</dt> <dd class="mask_value">Dinter, Juliane; M眉hlhaus, Jessica; Wienchol, Carolin Leonie; Yi, Chun-Xia; N眉rnberg, Daniela; Morin, Silke; Gr眉ters, Annette; K枚hrle, Josef; Sch枚neberg, Torsten; Tsch枚p, Matthias; Krude, Heiko; Kleinau, Gunnar; Biebermann, Heike</dd> <dt class="mask_label">Abstract:</dt> <dd class="mask_value"><div id="abstract_full" style="display:none">Application of 3-iodothyronamine (3-T1AM) results in decreased body temperature and body weight in rodents. The trace amine-associated receptor (TAAR) 1, a family A G protein-coupled receptor, is a target of 3-T1AM. However, 3-T1AM effects still persist in mTaar1 knockout mice, which suggest so far unknown further receptor targets that are of physiological relevance. TAAR5 is a highly conserved TAAR subtype among mammals and we here tested TAAR5 as a potential 3-T1AM target. First, we investigated mouse Taar5 (mTaar5) expression in several brain regions of the mouse in comparison to mTaar1. Secondly, to unravel the full spectrum of signaling capacities, we examined the distinct Gs-, Gi/o-, G12/13-, Gq/11- and MAP kinase-mediated signaling pathways of mouse and human TAAR5 under ligand-independent conditions and after application of 3-T1AM. We found overlapping localization of mTaar1 and mTaar5 in the amygdala and ventromedial hypothalamus of the mouse brain. Second, the murine and human TAAR5 (hTAAR5) display significant basal activity in the Gq/11 pathway but show differences in the basal activity in Gs and MAP kinase signaling. In contrast to mTaar5, 3-T1AM application at hTAAR5 resulted in significant reduction in basal IP3 formation and MAP kinase signaling. In conclusion, our data suggest that the human TAAR5 is a target for 3-T1AM, exhibiting inhibitory effects on IP3 formation and MAP kinase signaling pathways, but does not mediate Gs signaling effects as observed for TAAR1. This study also indicates differences between TAAR5 orthologs with respect to their signaling profile. In consequence, 3-T1AM-mediated effects may differ between rodents and humans.     <a href="#!" title="Text reduzieren" onclick="expandLongMetatext('abstract'); return false" class="mediatum-link-mediatum">«</a></div><div id="abstract_more"> Application of 3-iodothyronamine (3-T1AM) results in decreased body temperature and body weight in rodents. The trace amine-associated receptor (TAAR) 1, a family A G protein-coupled receptor, is a target of 3-T1AM. However, 3-T1AM effects still persist in mTaar1 knockout mice, which suggest so far unknown further receptor targets that are of physiological relevance. TAAR5 is a highly conserved TAAR subtype among mammals and we here tested TAAR5 as a potential 3-T1AM target. First, we investigat...     <a href="#!" title="gesamten Text zeigen" onclick="expandLongMetatext('abstract'); return false" class="mediatum-link-mediatum">»</a></div></dd> <dt class="mask_label">Zeitschriftentitel:</dt> <dd class="mask_value">PLoS ONE</dd> <dt class="mask_label">Jahr:</dt> <dd class="mask_value">2015</dd> <dt class="mask_label">Band / Volume:</dt> <dd class="mask_value">10</dd> <dt class="mask_label">Heft / Issue:</dt> <dd class="mask_value">2</dd> <dt class="mask_label">Seitenangaben Beitrag:</dt> <dd class="mask_value">e0117774</dd> <dt class="mask_label">Sprache:</dt> <dd class="mask_value">eng</dd> <dt class="mask_label">Volltext / DOI:</dt> <dd class="mask_value"><a href="https://doi.org/10.1371/journal.pone.0117774" target="_blank" title="In neuem Fenster anzeigen" class="mediatum-link-external">doi:10.1371/journal.pone.0117774</a></dd> <dt class="mask_label">PubMed:</dt> <dd class="mask_value"><a href="http://view.ncbi.nlm.nih.gov/pubmed/25706283" target="_blank" title="In neuem Fenster anzeigen" class="mediatum-link-external">http://view.ncbi.nlm.nih.gov/pubmed/25706283</a></dd> <dt class="mask_label">Print-ISSN:</dt> <dd class="mask_value">1932-6203</dd> <dt class="mask_label">TUM Einrichtung:</dt> <dd class="mask_value">Kliniken und Institute</dd> <dt class="action_icon"><a href="/export/1356493/bibtex" target="bibtexdocument" title="BibTeX Informationen in neuem Fenster 枚ffnen" class="mediatum-link-mediatum"><img src="/static/img/bibtex.gif" class="mediatum-icon-small"/> BibTeX</a> </dt> </dl>  <div class="clear"></div> </div> <div class="clear"></div>  <div id="paths"><b>Vorkommen:</b><br/> <ul> <li><a href="/604993" class="breadcrumb-delimiter mediatum-link-mediatum">mediaTUM Gesamtbestand</a><a href="/670273" class="breadcrumb-delimiter mediatum-link-mediatum">Einrichtungen</a><a href="/670274" class="breadcrumb-delimiter mediatum-link-mediatum">Schools </a><a href="/680583" class="breadcrumb-delimiter mediatum-link-mediatum">TUM School of Medicine and Health</a><a href="/1722655" class="breadcrumb-delimiter mediatum-link-mediatum">Departments</a><a href="/1356433" class="mediatum-link-mediatum">2015</a> </li> </ul> </div>  </div> <div style="clear:both;"></div> </div> <div style="clear:both"></div> <div id="footer"><span class="footer_left"><a href="mailto:mediatum@ub.tum.de" class="customcontent mediatum-link-external">mediatum@ub.tum.de</a><a href="/?item=604993_15.html" class="customcontent mediatum-link-internal">Kontakt</a><a href="/?item=604993_17.html" class="customcontent mediatum-link-internal">脺ber mediaTUM</a><a href="/?item=604993_14.html" class="customcontent mediatum-link-internal">Hilfe</a></span><span class="footer_right"><a href="/?item=604993_12.html" class="customcontent mediatum-link-internal">Nutzungsrechte</a><a href="/?item=604993_9.html" class="customcontent mediatum-link-internal">Datenschutz</a><a href="/?item=604993_18.html" class="customcontent mediatum-link-internal">Barrierefreiheit</a><a href="https://www.ub.tum.de/impressum" class="customcontent mediatum-link-external">Impressum</a></span> </div> </div> </body> </html>