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menu-item-type-post_type menu-item-object-page menu-item-710"><a href="https://verismotherapeutics.com/for-patients/">For Patients</a></li> </ul> </div> <div id="header_clear" class="homepage"></div> <div id="content_wrapper"> <main id="home-wrap"> <style> #homeBanner{ background-image: url(https://verismotherapeutics.com/wp-content/uploads/2022/09/banner-verismo-scaled.jpg); } @media(max-width: 767px){ #homeBanner{ background-image: url(https://verismotherapeutics.com/wp-content/uploads/2022/09/mobile-home-banner-v5-scaled-e1666124767771.jpg); } } .home-diagram-content-1{ background-image: url(https://verismotherapeutics.com/wp-content/uploads/2022/11/home-banner-diagram-2.png); } @media(max-width: 767px){ .home-diagram-content-1{ background-image: none!important; } } </style> <section id="homeBanner"> <div class="container banner_content"> <div class="row"> <div class="col-12 col-md-6 col-lg-6"> <h1>Paradigm-shifting CAR T cell therapy for solid tumors</h1> </div> </div> </div> <div id="home_banner_photo" style="background-image: url();"> </div> </section> <section id="r1"> <div class="container"> <div class="row justify-content-center"> <div class="col-12 col-md-9 text-center"> <h2>Defining the next generation<br /> of CAR T cell therapy</h2> <p>Verismo Therapeutics is pioneering CAR T cell therapy for the treatment of solid tumors. This paradigm-shifting technology features a unique KIR-CAR construct that has been proven to reduce T cell exhaustion and kill solid tumor models in in vivo studies.</p> </div> </div> </div> <div class="container pt-5"> <div class="row justify-content-center"> <div class="col-12 col-md-9 pb-5 text-center"> <h3>The paradigm shift in CAR T cell therapy</h3> </div> </div> <div class="home-diagram-content-1"> <div class="row justify-content-end mb-2 mb-md-5 pb-5"> <div class="col-12 col-md-5"> <p>Verismo’s paradigm-shifting generation 2.0 KIR-CAR platform:</p> <ul> <li>Features multi-chain immunoreceptor design</li> <li>Enables T cells to remain effective long-term</li> <li>Excels in challenging solid tumor micro-environments</li> </ul> </div> </div> <div class="d-block d-md-none"> <img src="https://verismotherapeutics.com/wp-content/uploads/2022/11/home-banner-mobile.png" alt=""> </div> <div class="row pt-5"> <div class="col-12 col-md-5"> <p>Prior 1.X CAR T cell therapies:</p> <ul> <li>Utilize the traditional single-chain CAR construct</li> <li>Fail to eliminate solid tumors</li> <li>Exhausts T cells through constant single-chain stimulation</li> </ul> </div> </div> </div> <div class="row justify-content-center"> <div class="col-12 col-md-9 text-center"> <div class="col-12 text-center mt-5"> <a href="https://verismotherapeutics.com/platform#sci-r3" target="" class="btn">CAR T History ></a> </div> </div> </div> </div> </section> <section id="r2"> <div class="container"> <div class="row justify-content-end pt-5 pb-5"> <div class="col-12 col-md-7"> <h2>The first KIR-CAR platform<br /> proven to be effective on<br /> solid tumors</h2> <p>Verismo is pioneering the further development of novel chimeric antigen receptors (CARs) to more realistically reflect the design of killer immunoglobulin-like receptors (KIRs), creating SynKIR™.</p> <p>Based on NK cell receptors, KIR-CAR naturally overcomes T cell exhaustion.</p> <p class="text-center text-md-left"><a class="btn" href="https://verismotherapeutics.com/platform/" >Our Platform ></a></p> </div> </div> </div> <div class="home-fbrg-1" style="background-image: url(https://verismotherapeutics.com/wp-content/uploads/2022/09/floating-brg-1.png);"> </div> </section> <section id="r3"> <div class="container"> <div class="row justify-content-center mb-5"> <div class="col-12 col-md-10 text-center"> <h2>The experts behind SynKIR</h2> <p>Verismo was founded by the inventors of Kymriah™. This team saw an opportunity to overcome the limitations found in the first-generation CAR T cell therapies, through the use of a KIR-CAR platform.</p> </div> </div> <div class="row mt-5 justify-content-center"> <div class="col-12 col-md-4 home-single-team"> <a href="https://verismotherapeutics.com/team#BryanKimDMD"> <div class="steam-photo"> <img src="https://verismotherapeutics.com/wp-content/uploads/2022/09/Bryan-Kimv3.jpg"> </div> <div class="steam-content"> <strong>Bryan Kim</strong> | DMD </div> </a> </div> <div class="col-12 col-md-4 home-single-team"> <a href="https://verismotherapeutics.com/team#LauraAJohnsonPhD"> <div class="steam-photo"> <img src="https://verismotherapeutics.com/wp-content/uploads/2022/09/laura-v2.jpg"> </div> <div class="steam-content"> <strong>Laura A Johnson</strong> | PhD </div> </a> </div> <div class="col-12 col-md-4 home-single-team"> <a href="https://verismotherapeutics.com/team#MichaelCMiloneMDPhD"> <div class="steam-photo"> <img src="https://verismotherapeutics.com/wp-content/uploads/2022/09/mike-v2.jpg"> </div> <div class="steam-content"> <strong>Michael C Milone </strong> | MD, PhD </div> </a> </div> <div class="col-12 col-md-4 home-single-team"> <a href="https://verismotherapeutics.com/team#DonaldSiegelMDPhD"> <div class="steam-photo"> <img src="https://verismotherapeutics.com/wp-content/uploads/2022/09/don-v2.jpg"> </div> <div class="steam-content"> <strong>Donald Siegel</strong> | MD, PhD </div> </a> </div> <div class="col-12 col-md-4 home-single-team"> <a href="https://verismotherapeutics.com/team#CarlJuneMD"> <div class="steam-photo"> <img src="https://verismotherapeutics.com/wp-content/uploads/2022/09/carl-v2.jpg"> </div> <div class="steam-content"> <strong>Carl June</strong> | MD </div> </a> </div> </div> <div class="row"> <div class="col-12 text-center mt-5"> <a href="https://verismotherapeutics.com/team/" target="" class="btn">Our Team ></a> </div> </div> </div> </section> <section id="r4"> <div class="container"> <div class="row justify-content-end"> <div class="col-12 col-md-7 mb-5"> <h2>A history of pioneering & proven technology</h2> </div> <div class="col-12 col-md-10"> <img class="d-block d-md-none" src="https://verismotherapeutics.com/wp-content/uploads/2022/11/home-timeline-mobile.png"> <img class="d-none d-md-block" src="https://verismotherapeutics.com/wp-content/uploads/2022/11/home-timeline-2.png"> </div> <div class="col-12 text-center mt-5"> <a href="https://verismotherapeutics.com/pipeline/" target="" class="btn">Our Pipeline ></a> </div> </div> </div> <div class="home-fbrg-2" style="background-image: url(https://verismotherapeutics.com/wp-content/uploads/2022/09/verismo.homepage.bottom.graphic.png);"> </div> </section> <section id="r5"> <div class="container"> <div class="row mb-5"> <div class="col-12 text-center"> <h2>Follow our progress</h2> </div> </div> <div class="row justify-content-center"> <div class="col-12 col-md-4 mb-3"> <div class="single-home-blog"> <div class="shb-cat"> <a href="https://verismotherapeutics.com/category/press-release/" rel="category tag">Press Release</a> </div> <div class="shb-title"> <a href="https://www.prnewswire.com/news-releases/verismo-therapeutics-announces-the-activation-of-its-celestial-301-clinical-trial-at-colorado-blood-cancer-institute-302269554.html?tc=eml_cleartime">Verismo Therapeutics Announces the Activation of its CELESTIAL-301 Clinical Trial at Colorado Blood Cancer Institute</a> </div> </div> </div> <div class="col-12 col-md-4 mb-3"> <div class="single-home-blog"> <div class="shb-cat"> <a href="https://verismotherapeutics.com/category/press-release/" rel="category tag">Press Release</a> </div> <div class="shb-title"> <a href="https://www.prnewswire.com/news-releases/verismo-therapeutics-awarded-a-scaleready-g-rex-grant-302249877.html">Verismo Therapeutics Awarded a ScaleReady™ G-Rex® Grant</a> </div> </div> </div> <div class="col-12 col-md-4 mb-3"> <div class="single-home-blog"> <div class="shb-cat"> <a href="https://verismotherapeutics.com/category/press-release/" rel="category tag">Press Release</a> </div> <div class="shb-title"> <a href="https://www.prnewswire.com/news-releases/verismo-therapeutics-receives-ind-clearance-from-the-fda-for-synkir-310-in-relapsedrefractory-b-cell-nhl-302144410.html">Verismo Therapeutics Receives IND Clearance from the FDA for SynKIR™-310 in Relapsed/Refractory B-cell NHL</a> </div> </div> </div> </div> <div class="row mt-5"> <div class="col-12 text-center mt-5"> <a href="https://verismotherapeutics.com/media/" target="" class="btn">Newsroom ></a> </div> </div> </div> </section> </main> </div> <footer> <div class="container"> <div class="row align-items-top"> <div class="col-12 col-md-5 mb-3 text-center text-md-left"> <a href="https://verismotherapeutics.com"><img src="https://verismotherapeutics.com/wp-content/uploads/2022/10/Verismo-Logo_rev.png"></a> </div> <div class="col-12 col-md-7 nav white"> <ul id="menu-main-menu-2" 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