Simple fracture risk prediction tests as useful as FRAX

<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd"> <html xmlns="http://www.w3.org/1999/xhtml"> <head id="Head1"><script type="text/javascript" src="/_static/js/bundle-playback.js?v=HxkREWBo" charset="utf-8"></script> <script type="text/javascript" src="/_static/js/wombat.js?v=txqj7nKC" charset="utf-8"></script> <script>window.RufflePlayer=window.RufflePlayer||{};window.RufflePlayer.config={"autoplay":"on","unmuteOverlay":"hidden"};</script> <script type="text/javascript" src="/_static/js/ruffle/ruffle.js"></script> <script type="text/javascript"> __wm.init("https://web.archive.org/web"); __wm.wombat("http://www.healio.com:80/endocrinology/bone-mineral-metabolism/news/online/%7Bcb4ee6f9-09b9-4d18-8e55-cba3fe6cdd5d%7D/simple-fracture-risk-prediction-tests-as-useful-as-frax","20130907150204","https://web.archive.org/","web","/_static/", "1378566124"); </script> <link rel="stylesheet" type="text/css" href="/_static/css/banner-styles.css?v=S1zqJCYt" /> <link rel="stylesheet" type="text/css" href="/_static/css/iconochive.css?v=3PDvdIFv" />  <meta http-equiv="Content-Type" content="text/html; charset=utf-8"/><title> Simple fracture risk prediction tests as useful as FRAX | Endocrinology </title>  <meta name="google-site-verification" content="TCYGZWR7Qscjc3GO_imiutAfXMSCFLpchm8rXzIk-5M"/><meta name="msvalidate.01" content="AB0F11E889D663098DB556BB5ACBB719"/><meta id="metaDescription" name="description" content="Endocrinology | The Fracture Risk Assessment Tool failed to predict risk for fracture any better than simpler tools, results from a 3-year prospective study show. &ldquo;In this study, we found that Fracture Risk Assessment Tool (FRAX) and simpler screening tools, such as OST, ORAI, OSIRIS, SCORE and even age alone, performed similarly in predicting fractures in a screening scenario without [bone mineral "/><meta id="metaKeywords" name="keywords" content="Endocrinology,Endocrinology,Orthopedics,Bone/Mineral Metabolism,Trauma,Osteoporosis,In the Journals"/><meta id="Meta1" name="scID"/><meta id="scID" name="scID"/><meta name="PostedDate" content="2013-08-16"/> <meta name="specialties" content="Endocrinology,Orthopedics"/> <meta name="specialty" content="Endocrinology"/> <meta name="specialty" content="Orthopedics"/> <meta name="primary_specialty" content="Endocrinology"/> <meta name="subspecialties" content="Bone/Mineral Metabolism,Trauma,Osteoporosis"/> <meta name="subspecialty" content="Bone/Mineral Metabolism"/> <meta name="subspecialty" content="Trauma"/> <meta name="subspecialty" content="Osteoporosis"/> <meta name="primary_subspecialty" content="Bone/Mineral Metabolism"/> <meta name="departments" content="In the Journals"/> <meta name="department" content="In the Journals"/> <meta name="content_type" content="News Article"/> <meta name="pageid" content="{CB4EE6F9-09B9-4D18-8E55-CBA3FE6CDD5D}"/> <meta property="og:image" content="https://web.archive.org/web/20130907150204im_/http://213a1ca8842e5e699a80-05ce35571e92a3f7383a191aa5840bba.r66.cf1.rackcdn.com/healio_safe_image.png"/><meta name="authors" content=""/><meta name="articleid" content="{CB4EE6F9-09B9-4D18-8E55-CBA3FE6CDD5D}"/><meta name="legacyarticleid" content=""/><meta name="article-title" content="Simple fracture risk prediction tests as useful as FRAX"/><meta name="article-link" content="/endocrinology/bone-mineral-metabolism/news/online/{cb4ee6f9-09b9-4d18-8e55-cba3fe6cdd5d}/simple-fracture-risk-prediction-tests-as-useful-as-frax"/><meta name="pubname" content="Endocrinology"/><meta name="pubtype" content="online"/><meta name="issue-name" content="16"/><meta name="issue-year" content=""/><meta name="source" content=""/><meta name="author" content=""/>  <link href="https://web.archive.org/web/20130907150204cs_/http://c341130.r30.cf1.rackcdn.com/styles.css" rel="stylesheet" type="text/css"/>  <link href="https://web.archive.org/web/20130907150204cs_/http://c341130.r30.cf1.rackcdn.com/styles2.css" rel="stylesheet" type="text/css"/><link href="https://web.archive.org/web/20130907150204cs_/http://c341130.r30.cf1.rackcdn.com/tb-ec-lb-min.css" rel="stylesheet" type="text/css" media="screen"/><link href="https://web.archive.org/web/20130907150204cs_/http://0043b493b06d545127da-d7c71b4c9ba1dd44e0cf6fa474e637d7.r99.cf1.rackcdn.com/healiojobs.css" rel="stylesheet" type="text/css"/><link href="https://web.archive.org/web/20130907150204cs_/http://6af4390358a281e0b439-028b17272c3ee5c2953a93a8c54187e2.r22.cf1.rackcdn.com/MediaKits.css" rel="stylesheet" type="text/css"/>  <link rel="shortcut icon" type="image/x-icon" href="https://web.archive.org/web/20130907150204im_/http://213a1ca8842e5e699a80-05ce35571e92a3f7383a191aa5840bba.r66.cf1.rackcdn.com/favicon.ico"/> <style type="text/css"> #wrap:before, #wrap:after { content: " "; display: table; } #wrap:after { clear: both; } </style> <script src="https://web.archive.org/web/20130907150204js_/http://ajax.googleapis.com/ajax/libs/jquery/1.8.2/jquery.min.js" type="text/javascript"></script> <script src="https://web.archive.org/web/20130907150204js_/http://cdn.jquerytools.org/1.2.7/full/jquery.tools.min.js" type="text/javascript"></script> <script type="text/javascript" language="javascript">$j = $.noConflict();</script> <script src="https://web.archive.org/web/20130907150204js_/http://c341136.r36.cf1.rackcdn.com/thickbox-compressed.js" type="text/javascript"></script> <script type="text/javascript"> var googletag = googletag || {}; googletag.cmd = googletag.cmd || []; (function() { var gads = document.createElement('script'); gads.async = true; gads.type = 'text/javascript'; var useSSL = 'https:' == document.location.protocol; gads.src = (useSSL ? 'https:' : 'http:') + '//web.archive.org/web/20130907150204/http://www.googletagservices.com/tag/js/gpt.js'; var node = document.getElementsByTagName('script')[0]; node.parentNode.insertBefore(gads, node); })(); </script> <script type="text/javascript"> googletag.cmd.push(function() { var slot0 = googletag.defineSlot('/6985521/Endocrinology_BoneMineralMetabolism_TopLeaderboard', [728, 90], 'div-gpt-ad-1369169134306-4').addService(googletag.pubads()); var slot1 = googletag.defineSlot('/6985521/Endocrinology_BoneMineralMetabolism_MediumRectangle', [[300, 600], [300, 250]], 'div-gpt-ad-1369169134306-3').addService(googletag.pubads()); googletag.defineSlot('/6985521/Endocrinology_TextLink1', [1, 1], 'div-gpt-ad-1369169134306-6').addService(googletag.pubads()); googletag.defineSlot('/6985521/Endocrinology_TextLink2', [1, 1], 'div-gpt-ad-1369169134306-7').addService(googletag.pubads()); var slot2 = googletag.defineSlot('/6985521/Endocrinology_BoneMineralMetabolism_MarketingRectangle1', [300, 100], 'div-gpt-ad-1369169134306-1').addService(googletag.pubads()); var slot3 = googletag.defineSlot('/6985521/Endocrinology_BoneMineralMetabolism_MarketingRectangle2', [300, 100], 'div-gpt-ad-1369169134306-2').addService(googletag.pubads()); var slot4 = googletag.defineSlot('/6985521/Endocrinology_BoneMineralMetabolism_BottomLeaderboard', [728, 90], 'div-gpt-ad-1369169134306-0').addService(googletag.pubads()); var slot5 = googletag.defineSlot('/6985521/Endocrinology_RunOfSpecialty_Interstitial', [300, 250], 'div-gpt-ad-1369169134306-5').addService(googletag.pubads()); googletag.pubads().setTargeting("Verification Status", "False"); googletag.pubads().enableSingleRequest(); googletag.enableServices(); setInterval(function(){googletag.pubads().refresh([slot0]);}, 9999999999); setInterval(function(){googletag.pubads().refresh([slot1]);}, 9999999999); setInterval(function(){googletag.pubads().refresh([slot2]);}, 9999999999); setInterval(function(){googletag.pubads().refresh([slot3]);}, 9999999999); setInterval(function(){googletag.pubads().refresh([slot4]);}, 9999999999); setInterval(function(){googletag.pubads().refresh([slot5]);}, 120000); }); </script> <script type="text/javascript">var NREUMQ=NREUMQ||[];NREUMQ.push(["mark","firstbyte",new Date().getTime()]);</script></head> <body id="Body"> <form method="post" action="/web/20130907150204/http://www.healio.com/endocrinology/bone-mineral-metabolism/news/online/{cb4ee6f9-09b9-4d18-8e55-cba3fe6cdd5d}/simple-fracture-risk-prediction-tests-as-useful-as-frax" id="frmMain"> <div class="aspNetHidden"> <input type="hidden" name="__VIEWSTATE" id="__VIEWSTATE" value="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"/> </div> <script src="https://web.archive.org/web/20130907150204js_/http://ajax.microsoft.com/ajax/4.0/2/MicrosoftAjax.js" type="text/javascript"></script> <div id="fb-root"> </div>  <div id="wrap">  <div id="header">  <div class="col1">  <div class="leaderboard">  <div id="div-gpt-ad-1369169134306-4"> <script type="text/javascript"> googletag.cmd.push(function() { googletag.display('div-gpt-ad-1369169134306-4'); }); </script> </div> </div>  <p class="survey">  <a href="https://web.archive.org/web/20130907150204/http://healio.wufoo.com/forms/z7x3x5/" onclick="window.open(this.href, null, 'height=768, width=680, toolbar=0, location=0, status=1, scrollbars=1, resizable=1'); return false" rel="nofollow">Tell us</a> what you think about Healio</p> <ul id="ulTopNav" class="utility-nav"> <li class="nw"><a href="https://web.archive.org/web/20130907150204/http://www.healio.com/footer/account-information/create-new-user?ReturnUrl=%2f"> News Wire Alerts</a></li> <li class="rss"><a href="https://web.archive.org/web/20130907150204/http://www.healio.com/rss">RSS Feeds</a></li> </ul>  <ul id="brand"> <li class="specialty-link-healio"> <h1 class="specialty-healio"><a href="/web/20130907150204/http://www.healio.com/">Healio</a></h1> <h1 class="specialty-sub"><a href="/web/20130907150204/http://www.healio.com/endocrinology">Endocrinology</a></h1> </li> <li class="logo"> <a href="/web/20130907150204/http://www.healio.com/endocrinology"><img alt="" height="61" width="401" src="/web/20130907150204im_/http://www.healio.com/endocrinology/bone-mineral-metabolism/news/online/%7Bcb4ee6f9-09b9-4d18-8e55-cba3fe6cdd5d%7D/~/media/15B090D51C184B5C9AE6108307AB4EE4.ashx"/></a> </li> </ul>  </div>   <div class="col2" id="greetingcontainer"> <script type="text/javascript"> $j(document).ready(function () {$j("#greeting").load("/Presentation/Layouts/Healio/Greeting.aspx",{'returnurl':'/endocrinology/bone-mineral-metabolism/news/online/{cb4ee6f9-09b9-4d18-8e55-cba3fe6cdd5d}/simple-fracture-risk-prediction-tests-as-useful-as-frax'}); }); </script> <div id="greeting"> <h4 class="pc-bar">Loading...</h4> <ul class="content"> <li class="update"> <p> <a href="/web/20130907150204/http://www.healio.com/footer/account-information/login.aspx"><strong>Sign in for a personal experience.</strong></a></p> <p> Customized content served to meet your interests. </p> </li> </ul>  </div>   <script type="text/javascript"> $j(document).ready(function () { var value1 = $j('input:radio[name=scope]:checked').val(); var value2 = ""; $j("#q").keyup(function (event) { if (event.keyCode == 13 && $j(this).val() != "") { $j("#btnG").click(); } }); $j("input:radio[name=scope]").click(function () { value1 = $j(this).val(); //alert(value1); }); $j("#btnG").click(function () { var u = searchRoot + "/search?q=" + $j("#q").val() + ((typeof (value1) === 'undefined' || value1 =="") ? "" : "&" + value1); window.location.replace(u); }); $j("#q").focus(function () { $j("#q").css('background', 'none') }); }); </script> <script language="javascript">var searchRoot='/endocrinology';</script> <div id="search"> <input type="text" id="q" name="q"/> <input type="button" class="submit" name="btnG" id="btnG" value="Search"/> <script src="https://web.archive.org/web/20130907150204js_/http://www.google.com/coop/cse/brand?form=cse-search-box&lang=en" type="text/javascript"></script>  <ul id="greetingContainer_ctl01_Refiner" class="form-controls"> <li> <input type="radio" name="scope" value=""/>All Specialties</li> <li>  <input type="radio" name="scope" value="requiredfields=specialty:Endocrinology" checked="checked"/>Endocrinology</li> </ul>  </div>  </div>  </div>   <div id="menu">   <ul id="subspecialty-menu-b"> <li class="first"><a class="collapsed" style="display:none;">Subspecialties</a> <ul> <li><a href="/web/20130907150204/http://www.healio.com/endocrinology" id="menu_0_anchorAll">All Endocrinology</a></li> <li><a class="resource" href="/web/20130907150204/http://www.healio.com/endocrinology/highlights-from-aade-2013"> Highlights from AADE 2013</a></li> <li><a class="resource" href="/web/20130907150204/http://www.healio.com/endocrinology/highlights-from-endo-2013"> Highlights from ENDO 2013</a></li> <li><a class="" href="/web/20130907150204/http://www.healio.com/endocrinology/adrenal"> Adrenal</a></li> <li><a class="active" href="/web/20130907150204/http://www.healio.com/endocrinology/bone-mineral-metabolism"> Bone/Mineral Metabolism</a></li> <li><a class="" href="/web/20130907150204/http://www.healio.com/endocrinology/cardiometabolic-disorders"> Cardiometabolic Disorders</a></li> <li><a class="" href="/web/20130907150204/http://www.healio.com/endocrinology/diabetes"> Diabetes</a></li> <li><a class="" href="/web/20130907150204/http://www.healio.com/endocrinology/diabetes-education"> Diabetes Education</a></li> <li><a class="" href="/web/20130907150204/http://www.healio.com/endocrinology/hormone-therapy"> Hormone Therapy</a></li> <li><a class="" href="/web/20130907150204/http://www.healio.com/endocrinology/neuroendocrinology"> Neuroendocrinology</a></li> <li><a class="" href="/web/20130907150204/http://www.healio.com/endocrinology/obesity"> Obesity</a></li> <li><a class="" href="/web/20130907150204/http://www.healio.com/endocrinology/pediatric-endocrinology"> Pediatric Endocrinology</a></li> <li><a class="" href="/web/20130907150204/http://www.healio.com/endocrinology/practice-management"> Practice Management</a></li> <li><a class="" href="/web/20130907150204/http://www.healio.com/endocrinology/reproduction-androgen-disorders"> Reproduction/Androgen Disorders</a></li> <li><a class="" href="/web/20130907150204/http://www.healio.com/endocrinology/thyroid"> Thyroid</a></li> <li><a class="resource" href="/web/20130907150204/http://www.healio.com/endocrinology/type-2-diabetes-resource-center"> Type 2 Diabetes Resource Center</a></li> </ul> </li> </ul> <ul id="specialty-menu-a"> <li> <h5 class="menu-head"> <a href="/web/20130907150204/http://www.healio.com/">All Specialties</a> </h5> </li> <li><a class="" href="/web/20130907150204/http://www.healio.com/adolescent-medicine"> Adolescent Medicine</a></li> <li><a class="" href="/web/20130907150204/http://www.healio.com/allergy-immunology"> Allergy/Immunology</a></li> <li><a class="" href="/web/20130907150204/http://www.healio.com/cardiology"> Cardiology</a></li> <li><a class="" href="/web/20130907150204/http://www.healio.com/dermatology"> Dermatology</a></li> <li><a class="active" href="/web/20130907150204/http://www.healio.com/endocrinology"> Endocrinology</a></li> <li><a class="" href="/web/20130907150204/http://www.healio.com/gastroenterology"> Gastroenterology</a></li> <li><a class="" href="/web/20130907150204/http://www.healio.com/geriatric-medicine"> Geriatric Medicine</a></li> <li><a class="" href="/web/20130907150204/http://www.healio.com/health-professions"> Health Professions</a></li> <li><a class="" href="/web/20130907150204/http://www.healio.com/hematology-oncology"> Hematology/Oncology</a></li> <li><a class="" href="/web/20130907150204/http://www.healio.com/hepatology"> Hepatology</a></li> <li><a class="" href="/web/20130907150204/http://www.healio.com/infectious-disease"> Infectious Disease</a></li> <li><a class="" href="/web/20130907150204/http://www.healio.com/nursing/journals"> Nursing</a></li> <li><a class="" href="/web/20130907150204/http://www.healio.com/ophthalmology"> Ophthalmology</a></li> <li><a class="" href="/web/20130907150204/http://www.healio.com/optometry"> Optometry</a></li> <li><a class="" href="/web/20130907150204/http://www.healio.com/orthopedics"> Orthopedics</a></li> <li><a class="" href="/web/20130907150204/http://www.healio.com/orthotics-prosthetics"> Orthotics/Prosthetics</a></li> <li><a class="" href="/web/20130907150204/http://www.healio.com/pediatrics"> Pediatrics</a></li> <li><a class="" href="/web/20130907150204/http://www.healio.com/psychiatry"> Psychiatry</a></li> <li><a class="" href="/web/20130907150204/http://www.healio.com/rheumatology"> Rheumatology</a></li> <li><a class="" href="/web/20130907150204/http://www.healio.com/sports-medicine"> Sports Medicine</a></li> </ul> <div id="awardgroup"> <ul class="award-wrap"> <li class="col1"><a href="/web/20130907150204/http://www.healio.com/hematology-oncology/practice-management/news/online/%7Bbaa1a66a-8c99-4530-b5b2-4bd5946fd8c9%7D/healiocom-wins-2012-best-publishing-site-award" rel="nofollow">Sitecore Site of the Year</a></li> <li class="col2"><a href="/web/20130907150204/http://www.healio.com/news/online/%7B58FDC6A6-27D7-4AD3-8D3E-ED63D35F8BE2%7D/Healiocom-named-Medical-Marketing--Media-2013-award-finalist" rel="nofollow">Finalist - MMM Awards 2013</a></li> <li class="col3"><a href="/web/20130907150204/http://www.healio.com/news/online/%7BC15DEDA5-C675-417E-B896-80686B2C137C%7D/Healiocom-wins-2013-APEX-Grand-Award" rel="nofollow">Healio.com wins 2013 APEX Grand Award</a></li> </ul> </div> </div>   <div id="content-wrap">  <ul class="nav"> <li><a href="/web/20130907150204/http://www.healio.com/endocrinology/news" title="News" target=""> News</a> <ul class="sub_menu"> <li class="first"> <a class="all" href="/web/20130907150204/http://www.healio.com/endocrinology/news" title="News" target=""> All News</a> </li> <li class="first"> <a class="all" href="#" title="News" target=""> News Publications</a> </li> <li class=""> <a class="" href="/web/20130907150204/http://www.healio.com/endocrinology/bone-mineral-metabolism/news/print/endocrine-today" title="News" target=""> Endocrine Today</a> </li> <li class=""> <a class="" href="/web/20130907150204/http://www.healio.com/endocrinology/news/publication-exclusives" title="News" target=""> Publication Exclusives</a> </li> <li class="first"> <a class="all" href="/web/20130907150204/http://www.healio.com/endocrinology/news/meeting-news-coverage" title="News" target=""> Meeting News Coverage</a> </li> </ul> </li> <li><a href="https://web.archive.org/web/20130907150204/http://video.healio.com/pages/endocrinology" title="Video" target=""> Video</a> <ul class="sub_menu"> </ul> </li> <li><a href="/web/20130907150204/http://www.healio.com/endocrinology/blogs" title="Blogs" target=""> Blogs</a> <ul class="sub_menu"> <li class="first"> <a class="all" href="/web/20130907150204/http://www.healio.com/endocrinology/blogs" title="News" target=""> All Blogs</a> </li> <li class=""> <a class="" href="/web/20130907150204/http://www.healio.com/endocrinology/blogs/michael-kleerekoper-md-mace" title="News" target=""> Michael Kleerekoper MD MACE</a> </li> <li class=""> <a class="" href="/web/20130907150204/http://www.healio.com/endocrinology/blogs/thomas-b-repas-do-facp-face-cde" title="News" target=""> Thomas B Repas DO FACP FACE CDE</a> </li> </ul> </li> <li><a href="/web/20130907150204/http://www.healio.com/endocrinology/education-lab" title="Education Lab/CME" target=""> Education Lab/CME</a> <ul class="sub_menu"> <li class="first"> <a class="" href="/web/20130907150204/http://www.healio.com/endocrinology/education-lab" title="News" target=""> Education Lab Home</a> </li> <li class=""> <a class="" href="/web/20130907150204/http://www.healio.com/endocrinology/education-lab?selection=0" title="News" target=""> CME</a> </li> </ul> </li> <li><a href="/web/20130907150204/http://www.healio.com/endocrinology/books" title="Books" target=""> Books</a> <ul class="sub_menu"> </ul> </li> <li><a href="/web/20130907150204/http://www.healio.com/endocrinology/meetings" title="Meetings" target=""> Meetings</a> <ul class="sub_menu"> <li class="first"> <a class="all" href="/web/20130907150204/http://www.healio.com/endocrinology/meetings" title="News" target=""> Meetings/Courses</a> </li> <li class="first"> <a class="all" href="/web/20130907150204/http://www.healio.com/endocrinology/meetings/meeting-news-coverage" title="News" target=""> Meeting News Coverage</a> </li> </ul> </li> <li><a href="/web/20130907150204/http://www.healio.com/endocrinology/careers" title="Careers" target=""> Careers</a> <ul class="sub_menu"> </ul> </li> </ul> <script type="text/javascript"> jQuery(".nav>li:last>a").addClass("last"); //fix for IE last-child style </script>   <div id="main-content">  <p id="breadcrumbs"> <a href="/web/20130907150204/http://www.healio.com/"> Healio</a> <span>›</span> <a href="/web/20130907150204/http://www.healio.com/endocrinology"> Endocrinology</a> <span>›</span> <a href="/web/20130907150204/http://www.healio.com/endocrinology/bone-mineral-metabolism"> Bone/Mineral Metabolism</a> <span>›</span> <a href="/web/20130907150204/http://www.healio.com/endocrinology/bone-mineral-metabolism/news"> News</a> </p>   <div id="SeeAlso" class="related-links"><h3>See Also</h3><ul><li><a href="https://web.archive.org/web/20130907150204/http://www.healio.com/endocrinology/bone-mineral-metabolism/news/print/endocrine-today/%7Bd3a3996d-856e-4789-9d03-152bd7f319cc%7D/frax-with-or-without-bmd-predicted-fractures-in-obese-nonobese-women">FRAX with or without BMD predicted fractures in obese ...</a></li><li><a href="https://web.archive.org/web/20130907150204/http://www.healio.com/endocrinology/bone-mineral-metabolism/news/online/%7B1b4d9d78-4594-4b79-a250-f0e78f318fa0%7D/risk-for-fracture-reduced-by-single-infusion-of-zoledronic-acid">Risk for fracture reduced by single infusion of zoledronic acid ...</a></li><li><a href="https://web.archive.org/web/20130907150204/http://www.healio.com/endocrinology/bone-mineral-metabolism/news/online/%7B751b25fc-8f23-47e0-b224-9e9b1c523e31%7D/denosumab-reduced-wrist-fracture-in-postmenopausal-women-with-osteoporosis">Denosumab reduced wrist fracture in postmenopausal women ...</a></li></ul></div> <input name="layout_0$maincontent_0$seeAlsoInsertUnderParagraph" type="hidden" id="layout_0_maincontent_0_seeAlsoInsertUnderParagraph" value="1"/>  <div class="content"> <h2> Simple fracture risk prediction tests as useful as FRAX</h2> <h3 class="deck"> <a href="https://web.archive.org/web/20130907150204/http://www.thebonejournal.com/article/S8756-3282%2813%2900184-1/abstract" target="blank">Rubin KH. <i>Bone</i>. 2013;56:16-22.</a></h3> <p class="main-subtitle"> </p> <div class="social-links-top"> <ul class="share"> <li class="l1"><a href="javascript:void(0)" class="facebook-link" target="_new">Facebook</a></li> <li class="l2"><a href="javascript:void(0)" class="twitter-link" target="_new">Tweet</a></li> <li class="l3"><a href="javascript:void(0)" class="linkedin-link">Share</a></li> </ul> </div> <ul class="meta-info"> <li> August 16, 2013</li> </ul> <div class="wyContent"> <p>The Fracture Risk Assessment Tool failed to predict risk for fracture any better than simpler tools, results from a 3-year prospective study show.</p> <p>“In this study, we found that Fracture Risk Assessment Tool (<a href="https://web.archive.org/web/20130907150204/http://www.healio.com/endocrinology/search?q=FRAX%20&requiredfields=specialty:Endocrinology" target="blank">FRAX</a>) and simpler screening tools, such as OST, ORAI, OSIRIS, SCORE and even age alone, performed similarly in predicting fractures in a screening scenario without [bone mineral density] assessment,” <strong>Katrine Hass Rubin, PhD,</strong> of the Institute of Clinical Research at the University of Southern Denmark and department of medical endocrinology at Odense University Hospital, and colleagues wrote. </p> <p>The population-based study included 5,000 randomly selected women aged 40 to 90 years (BMI, 26 kg/m2; mean age, 64 years) living in southern Denmark. Questionnaires regarding risk factors for <a href="https://web.archive.org/web/20130907150204/http://www.healio.com/endocrinology/search?q=osteoporosis%20&requiredfields=specialty:Endocrinology" target="blank">osteoporosis</a> were administered to the patients; self-reported baseline data were used to measure 10-year likelihood of fracture by FRAX and to estimate the risk based on other tools. Age was also considered as a continuous variable, according to researchers.</p> <div class="mug right"><img width="90" height="120" alt="Katrine Hass Rubin, PhD" src="/web/20130907150204im_/http://www.healio.com/~/media/Images/Mugs/Endocrinology/R/Rubin_Katrine Hass_90x120.jpg"/>  <p class="name"><strong>Katrine Hass Rubin</strong></p> </div> <p></p> <p>Rubin and colleagues identified incident fracture outcomes at follow-up, including “major osteoporotic fractures” (ie, FRAX-defined major osteoporotic fracture and hip, clinical vertebral, wrist or humerus fracture), in addition to all other fractures, excluding those of the fingers, toes, skull or face. </p> <p>After 3 years, 3,860 questionnaires were completed (10,385 person-years), with 225 (6%) of women reporting an osteoporotic fracture. According to data, patients with incident fractures tended to be older (73 years vs. 63 years; <i>P</i>=.0001), had more frequent history of fractures (22% vs. 9%; <i>P</i><.001) and falls during the past 12 months (14% vs. 6%; <i>P</i><.001), had diseases related to secondary osteoporosis (26% vs. 18%, <i>P</i>=.011), and with less frequent <a href="https://web.archive.org/web/20130907150204/http://www.healio.com/endocrinology/search?q=estrogen&requiredfields=specialty:Endocrinology" target="blank">estrogen</a> use (3% vs. 11%; <i>P</i>=.001).</p> <p>Furthermore, age restrictions in the analysis did not yield significant differences in area-under-the-curve values between the various screening tools, according to researchers.</p> <p>“These findings suggest that simpler tools based on fewer risk factors, which would be easier to use in clinical practice by the general practitioner or the patient herself, could just as well as FRAX be used to identify women with increased risk of fracture and therefore should be referred to a DXA scan,” researchers wrote.</p> <p><strong>Disclosure:</strong> The researchers report no relevant financial disclosures. </p> </div>  <div class="fig left"> <p class="figcaption"> </p> </div> <div class="wyPagination">   </div>   <div class="perspective"> <a name="perspective" id="perspective"></a> <div class="flag"> <span class="perspective-flag">Perspective</span></div> <div class="col1"> <img src="/web/20130907150204im_/http://www.healio.com/~/media/Images/Mugs/Endocrinology/M/McClung_Michael.jpg" alt="Michael McClung, MD" width="90" height="120"/> <p class="caption"> Michael R. McClung</p> </div> <div class="col2"> <ul> <li> <p class="PerspectivebodyCxSpFirst">It is important to have tools to assess the risk of fracture in individual patients so that pharmacologic therapy can be targeted appropriately. As fracture risk increases, the benefit of treatment is enhanced and the risk-benefit profile is optimized. The most important determinants of fracture risk are age, bone mineral density and prior fracture history. Because of the very strong correlation between body weight and BMD, weight or BMI can be used as a surrogate when BMD is not available. Other risk factors, including smoking, excessive alcohol intake, parental hip history of fracture and glucocorticoid use modify the risk of fracture, in complex ways, in individuals who have these risk factors. The FRAX tool is a very sophisticated, scientifically sound computer-based risk assessment tool incorporating all of these risk fractures, adjusting for the complex interplay among the various risk factors. The output of FRAX is the 10-year likelihood of either major osteoporotic fractures or hip fracture. In the USA, race is also considered. Age-specific mortality is taken into account since, especially among elderly patients; the risk of dying reduces the risk of having a fracture.  </p> <p class="PerspectivebodyCxSpMiddle">The study by Rubin and colleagues compared the effectiveness of the FRAX model without BMD with age alone and several more simple tools to identify patients who developed a fragility fracture over a 3-year follow-up interval in a community-based cohort of women in southern Denmark. The non-FRAX tools had been developed and validated to identify patients with low bone density and had not been previously validated as predictors of fracture risk. The authors correctly conclude that the simple models were as good or nearly as good as the more complicated FRAX calculation in predicting fracture risk in their patient population. At first glance, these results suggest that the FRAX tool is needlessly complex. However, the women evaluated in this study were quite healthy and had few risk factors for fracture. Their average age was 64 years. Only 9% had a history of prior fracture, 4% had a history of glucocorticoid use, and 2% reported excessive use of alcohol, explaining why their average 10 year probability of a major osteoporotic fracture by FRAX was only 6%. Very few were elderly, and the short follow-up time of 3 years blunted the impact of including mortality in FRAX. For these relatively healthy women, the risk factors that drive the FRAX score are predominantly and body size, the same risk factors that form the basis of the “more simple” tools. The “complexities” of FRAX are most useful in elderly patients who have other risk factors for fracture. In addition, FRAX quantifies the risk whereas the “simple” tools segregate patients into categories of risk. </p> <p style="margin: 0in 0in 10pt;" class="PerspectivebodyCxSpLast">In my opinion, the results described by Rubin are not expected and do not undermine the utility or importance of FRAX. The FRAX algorithm is the most scientifically validated tool to predict fracture risk and is the only tool whose results have been incorporated into treatment guidelines by the National Osteoporosis Foundation, The Endocrine Society, AACE and other professional organizations. The importance of FRAX, or of any tool that accurately predicts fracture risk, is to allow us to make treatment decisions based on knowledge of fracture risk and to move away from the incorrect strategy of simply treating bone density values.</p></li> <ul class="cite"> <li><strong> Michael R. McClung, MD</strong> </li> <li><cite> Oregon Osteoporosis Center<br/>Portland, OR</cite> </li> </ul> <li id="layout_0_maincontent_1_Perspectives_RptPerspective_liDisclosure_0" class="disclosure"> <strong>Disclosures:</strong> McClung reports no relevant financial disclosures. </li> </ul> </div> </div>  <div class="follow"> <img src="/web/20130907150204im_/http://www.healio.com/~/media/Images/News/FollowUs.jpg" id="layout_0_maincontent_1_SocialFollow_socialfollow" name="socialfollow" alt="Follow us" usemap="#followus" border="0"/> <map id="followus" name="followus"> <area id="layout_0_maincontent_1_SocialFollow_followfb" shape="rect" coords="51,5,5,51" target="_blank" href="https://web.archive.org/web/20130907150204/http://www.facebook.com/endocrinetoday" alt="Follow us on Facebook"></area> <area id="layout_0_maincontent_1_SocialFollow_followtw" shape="rect" coords="241,3,281,50" target="_blank" href="https://web.archive.org/web/20130907150204/http://www.twitter.com/endocrinetoday" alt="Follow us on Twitter"></area> </map> </div> </div>  <div class="social-links"> <div class="fb-like" data-send="false" data-width="300" data-show-faces="true" data-action="recommend"></div> <ul class="share"> <li><a href="javascript:void(0)" id="twitter" class="twitter-link" target="_new">Tweet</a></li> <li><a href="javascript:void(0)" id="facebook" class="facebook-link" target="_new">Share</a></li> <li class="linkedin"><a href="javascript:void(0)" id="linkedin" class="linkedin-link">Link</a></li> <li><span class="db-wrapper"><span class="g-plusone" data-size="tall" data-annotation="none"></span></span></li> <li><a href="javascript:void(0)" id="email">Email</a></li> <li class="last"><a href="javascript:void(0)" id="print">Print</a></li> </ul> <input name="layout_0$maincontent_1$SocialMedia$articleItemForTweet" type="hidden" id="layout_0_maincontent_1_SocialMedia_articleItemForTweet" value="{CB4EE6F9-09B9-4D18-8E55-CBA3FE6CDD5D}"/> </div>  <div id="respond"> <h4> Comments</h4> <script language="javascript" type="text/javascript"> var idcomments_acct = 'aa6ff53f9870e40f92f83e1b5df3cddf'; var idcomments_post_id = '{CB4EE6F9-09B9-4D18-8E55-CBA3FE6CDD5D}'; var idcomments_post_url; </script> <span id="IDCommentsPostTitle" style="display: none"></span> <script type="text/javascript" src="https://web.archive.org/web/20130907150204js_/http://www.intensedebate.com/js/genericCommentWrapperV2.js"></script> <p class="comment-notes"> Healio is intended for health care provider use and all comments will be posted at the discretion of the editors. We reserve the right not to post any comments with unsolicited information about medical devices or other products. At no time will Healio be used for medical advice to patients. </p> </div>   <div id="video-channel"> </div>  </div>    <div id="sidebar">   <div id="featured-most-popular" class="featured-tabs"> <div class="featured-tab-group"> <ul class="tabs"> <li><a class="active" href="#featured">Featured</a> </li> <li><a href="#mostpopular">Most Popular</a> </li> </ul>  <div class="panes">  <div id="featured"> <ul class=""> <li class="kicker"> <span class="dept">In the Journals</span> </li> <li> <h4> <a href="/web/20130907150204/http://www.healio.com/endocrinology/bone-mineral-metabolism/news/online/{36206fc1-25c7-49e0-87cd-bbfee46b90e5}/antidepressants-did-not-increase-risk-for-bone-loss-in-middle-aged-women"> Antidepressants did not increase risk for bone loss in middle-aged women</a></h4> </li> <li class="meta-info"> September 6, 2013</li> </ul> <ul class=""> <li class="kicker"> </li> <li> <h4> <a href="https://web.archive.org/web/20130907150204/http://video.healio.com/video/meet-dr-nelson-watts"> Meet Dr Nelson Watts</a></h4> </li> <li class="meta-info"> November 30, 2012</li> </ul> <ul class=""> <li class="kicker"> <span class="dept">In the Journals</span> </li> <li> <h4> <a href="/web/20130907150204/http://www.healio.com/endocrinology/bone-mineral-metabolism/news/online/{179cf4d5-b256-4e28-b5bb-dcd092ebc001}/calcium-vitamin-d-failed-to-halt-bmd-loss-in-breast-cancer"> Calcium, vitamin D failed to halt BMD loss in breast cancer </a></h4> </li> <li class="meta-info"> September 5, 2013</li> </ul> </div>  <div id="mostpopular"> <ul class=""> <li class="kicker"> </li> <li> <h4> <a href="/web/20130907150204/http://www.healio.com/endocrinology/thyroid/news/online/{59026951-a773-4c02-873f-9b64c3e0def3}/new-ata-recommendations-target-thyroid-study-design-standardization"> New ATA recommendations target thyroid study design, standardization</a></h4> </li> <li class="meta-info"> September 5, 2013</li> </ul> <ul class=""> <li class="kicker"> <span class="dept">In the Journals</span> </li> <li> <h4> <a href="/web/20130907150204/http://www.healio.com/endocrinology/bone-mineral-metabolism/news/online/{36206fc1-25c7-49e0-87cd-bbfee46b90e5}/antidepressants-did-not-increase-risk-for-bone-loss-in-middle-aged-women"> Antidepressants did not increase risk for bone loss in middle-aged women</a></h4> </li> <li class="meta-info"> September 6, 2013</li> </ul> <ul class=""> <li class="kicker"> <span class="dept">In the Journals</span> </li> <li> <h4> <a href="/web/20130907150204/http://www.healio.com/rheumatology/rheumatoid-arthritis/news/online/{5cd76036-9850-4b7d-8a31-079d1f9542a5}/african-ra-patients-had-reduced-adiposity-no-significant-association-with-cardiovascular-risk-factors"> African RA patients had reduced adiposity, no significant association with cardiovascular risk factors</a></h4> </li> <li class="meta-info"> September 6, 2013</li> </ul> </div> </div> </div> </div>   <div class="sidebar-ad-box">  <div id="div-gpt-ad-1369169134306-3"> <script type="text/javascript"> googletag.cmd.push(function() { googletag.display('div-gpt-ad-1369169134306-3'); }); </script> </div> </div>  <div id="personalized-content"> <div class="sidebar-box" id="personalized"> <h4 class="pc-bar"> Personalize your page!</h4> <p> Register for Healio to get content tailored to your specialty and areas of interest. It鈥檚 FREE and only takes one minute. <a id="layout_0_ctl01_sidebarbelowad_0_RegisterNow" rel="nofollow" href="/web/20130907150204/http://www.healio.com/footer/account-information/login">Register now!</a></p> </div> </div>  <div id="custom-Poll" class="sidebar-box"> <script type="text/javascript" charset="utf-8" src="https://web.archive.org/web/20130907150204js_/http://static.polldaddy.com/p/7342845.js"></script> <noscript><a href="https://web.archive.org/web/20130907150204/http://polldaddy.com/poll/7342845/">Do the benefits of statin therapy outweigh the risks?</a></noscript> <p class="poll-related-link"><a href="/web/20130907150204/http://www.healio.com/endocrinology/diabetes/news/print/endocrine-today/{c2f2ab37-e811-4725-8433-3821a4747753}/statins-and-diabetes-whether-benefits-outweigh-the-risks">See related content »</a></p> </div>    <div id="text-ad" class="sidebar-box"> <h5> Advertisement </h5> <ul> <li class="first"><strong>Resources from Industry</strong> </li> <li id="layout_0_ctl01_Ad1">  <div id="div-gpt-ad-1369169134306-6"> <script type="text/javascript"> googletag.cmd.push(function() { googletag.display('div-gpt-ad-1369169134306-6'); }); </script> </div> </li><li id="layout_0_ctl01_Ad2" class="last">  <div id="div-gpt-ad-1369169134306-7"> <script type="text/javascript"> googletag.cmd.push(function() { googletag.display('div-gpt-ad-1369169134306-7'); }); </script> </div> </li> </ul> </div>  <div class="sidebar-ad-box">  <div id="div-gpt-ad-1369169134306-1"> <script type="text/javascript"> googletag.cmd.push(function() { googletag.display('div-gpt-ad-1369169134306-1'); }); </script> </div> </div> <div class="sidebar-ad-box">  <div id="div-gpt-ad-1369169134306-2"> <script type="text/javascript"> googletag.cmd.push(function() { googletag.display('div-gpt-ad-1369169134306-2'); }); </script> </div> </div> </div>   <div style="clear: left; position: relative; top: 15px; left: 5px; width: 500px;"></div> </div>  </div>   <div id="footer"> <div class="btm-leaderboard">  <div id="div-gpt-ad-1369169134306-0"> <script type="text/javascript"> googletag.cmd.push(function() { googletag.display('div-gpt-ad-1369169134306-0'); }); </script> </div> </div> <div id="footer-link-group"> <div class="footer-link-group-1"> <h5> Account Information</h5> <ul class="col1"> <li class=""><a href="/web/20130907150204/http://www.healio.com/footer/account-information/create-new-user?ReturnUrl=%2fendocrinology%2fbone-mineral-metabolism%2fnews%2fonline%2f%7bcb4ee6f9-09b9-4d18-8e55-cba3fe6cdd5d%7d%2fsimple-fracture-risk-prediction-tests-as-useful-as-frax" target="_self"> Create New User</a></li> <li class=""><a href="/web/20130907150204/http://www.healio.com/footer/account-information/expired-promotion" target="_self"> </a></li> <li class=""><a href="/web/20130907150204/http://www.healio.com/footer/account-information/login?ReturnUrl=%2fendocrinology%2fbone-mineral-metabolism%2fnews%2fonline%2f%7bcb4ee6f9-09b9-4d18-8e55-cba3fe6cdd5d%7d%2fsimple-fracture-risk-prediction-tests-as-useful-as-frax" target="_self" rel="nofollow"> Login</a></li> <li class=""><a href="/web/20130907150204/http://www.healio.com/footer/account-information/update-publication-mailing-address" target="_self"> Update Publication Mailing Address</a></li> </ul> <ul class="col2"> <li class=""><a href="/web/20130907150204/http://www.healio.com/subscribe" target="_self"> Subscribe Or Buy</a></li> <li class=""><a href="/web/20130907150204/http://www.healio.com/footer/account-information/help" target="_self"> Help</a></li> </ul> </div> <div class="footer-link-group-2"> <h5> Healio.com</h5> <ul class="col1"> <li class=""><a href="/web/20130907150204/http://www.healio.com/footer/healio-dot-com/about-healio" target="_self"> About Healio</a></li> <li class=""><a href="/web/20130907150204/http://www.healio.com/footer/healio-dot-com/publications" target="_self"> Publications</a></li> <li class=""><a href="/web/20130907150204/http://www.healio.com/footer/healio-dot-com/editorial-board" target="_self"> Editorial Board</a></li> <li class=""><a href="/web/20130907150204/http://www.healio.com/footer/healio-dot-com/contact-the-news-desk" target="_self"> Contact the News Desk</a></li> </ul> <ul class="col2"> <li class=""><a href="/web/20130907150204/http://www.healio.com/footer/healio-dot-com/contact-us" target="_self"> Contact Us</a></li> <li class=""><a href="/web/20130907150204/http://www.healio.com/footer/healio-dot-com/about-the-wyanoke-group" target="_self"> About the Wyanoke Group</a></li> <li class=""><a href="/web/20130907150204/http://www.healio.com/footer/healio-dot-com/advertising-information" target="_self"> Advertising Information</a></li> <li class=""><a href="/web/20130907150204/http://www.healio.com/footer/healio-dot-com/reprints" target="_self"> Reprints</a></li> </ul> <ul class="col3"> <li class=""><a href="/web/20130907150204/http://www.healio.com/footer/healio-dot-com/sitemap" target="_self"> Sitemap</a></li> </ul> </div> <div class="footer-link-group-3"> <h5> Legal</h5> <ul class="col1"> <li class=""><a href="/web/20130907150204/http://www.healio.com/footer/legal/medical-disclaimer" target="_self"> Medical Disclaimer</a></li> <li class=""><a href="/web/20130907150204/http://www.healio.com/footer/legal/privacy-policy" target="_self"> Privacy Policy</a></li> <li class=""><a href="/web/20130907150204/http://www.healio.com/footer/legal/editorial-policy-and-philosophy" target="_self"> Editorial Policy and Philosophy</a></li> <li class=""><a href="/web/20130907150204/http://www.healio.com/footer/legal/terms-and-conditions" target="_self"> Terms and Conditions</a></li> </ul> <ul class="col2"> <li class=""><a href="/web/20130907150204/http://www.healio.com/footer/legal/permissions" target="_self"> Permissions</a></li> </ul> </div> <div class="footer-link-group-4"> <h5> Connect with Healio</h5> <ul class=""> <li class="twitter"><a href="https://web.archive.org/web/20130907150204/https://twitter.com/#!/GoHealio" target="_blank"> Twitter</a></li> <li class="fb"><a href="https://web.archive.org/web/20130907150204/http://www.facebook.com/pages/Healio/304788272902541" target="_blank"> Facebook</a></li> <li class="rss"><a href="/web/20130907150204/http://www.healio.com/rss" target="_self"> RSS Feeds</a></li> </ul> </div> </div> <p class="copyright">©2013 All Rights Reserved.</p> <a href="https://web.archive.org/web/20130907150204/http://www.healio.com/pearlescentcabinet.aspx"></a> </div>  </form>  <script src="https://web.archive.org/web/20130907150204js_/http://c341136.r36.cf1.rackcdn.com/easySlider-min.js" type="text/javascript" defer="defer"></script> <script src="https://web.archive.org/web/20130907150204js_/http://c341136.r36.cf1.rackcdn.com/jquery.pager.js" type="text/javascript" defer="defer"></script> <script src="https://web.archive.org/web/20130907150204js_/http://c341136.r36.cf1.rackcdn.com/jquery.jqprint-0.3.js" type="text/javascript" defer="defer"></script> <script src="https://web.archive.org/web/20130907150204js_/http://c341136.r36.cf1.rackcdn.com/jquery.lightbox-0.5.min.js" type="text/javascript" defer="defer"></script> <script src="https://web.archive.org/web/20130907150204js_/http://c341136.r36.cf1.rackcdn.com/ecommerce-min.js" type="text/javascript" language="javascript"></script> <script src="https://web.archive.org/web/20130907150204js_/http://c341136.r36.cf1.rackcdn.com/functions-min.js" type="text/javascript" language="javascript"></script> <script src="https://web.archive.org/web/20130907150204js_/http://c341136.r36.cf1.rackcdn.com/checkout-min.js" type="text/javascript"></script> <script src="https://web.archive.org/web/20130907150204js_/http://c341136.r36.cf1.rackcdn.com/jquery.url.min.js" type="text/javascript"></script> <script src="https://web.archive.org/web/20130907150204js_/http://50f7680153f6cba9e65f-a4a4842ad50f9edc1b98e79695b0495a.r26.cf1.rackcdn.com/WaterMark.min.js" type="text/javascript"></script> <script src="https://web.archive.org/web/20130907150204js_/http://50f7680153f6cba9e65f-a4a4842ad50f9edc1b98e79695b0495a.r26.cf1.rackcdn.com/registration.js" type="text/javascript"></script> <script type="text/javascript" language="javascript" src="https://web.archive.org/web/20130907150204js_/http://50f7680153f6cba9e65f-a4a4842ad50f9edc1b98e79695b0495a.r26.cf1.rackcdn.com/dfpexpand.js"></script> <script type="text/javascript" language="javascript" src="https://web.archive.org/web/20130907150204js_/http://50f7680153f6cba9e65f-a4a4842ad50f9edc1b98e79695b0495a.r26.cf1.rackcdn.com/moduleTracking.js"></script>  <script type="text/javascript" src="https://web.archive.org/web/20130907150204js_/http://c341136.r36.cf1.rackcdn.com/healiojs-min20130821.js"></script> <script type="text/javascript"> var _gaq = _gaq || []; var pluginUrl = 'https://web.archive.org/web/20130907150204/http://www.google-analytics.com/plugins/ga/inpage_linkid.js'; _gaq.push(['_require', 'inpage_linkid', pluginUrl]); _gaq.push(['_setAccount', 'UA-671605-73']); _gaq.push(['_trackPageview']); _gaq.push(['_setCustomVar',1,'Profession','',1]); _gaq.push(['_setCustomVar',2,'Specialty','|',1]); _gaq.push(['_setCustomVar',3,'Verification Status','False',1]); _gaq.push(['_setCustomVar',5,'UserID','',1]); _gaq.push(['_setCustomVar',4,'Section','Endocrinology|Bone/Mineral Metabolism|News',3]); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://web.archive.org/web/20130907150204/https://ssl' : 'https://web.archive.org/web/20130907150204/http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); function trackClick(link,category,action, label, isExternal) { if(isExternal == null) isExternal = 0; if(label == null) label = link; if(isExternal == 0){ label = 'Internal - ' + label; } else{ label = 'External - ' + label; } _gaq.push(['_setAccount', 'UA-671605-73']); _gaq.push(['_trackEvent', category, action, label]); if(isExternal == 0) { setTimeout('window.location=\'' + link + '\'', 100); } return true; } function gInitLightbox() { var anchors = document.getElementsByTagName('a'); var imgTypes = new Array("jpg", "gif", "png"); var tgtTypes = new Array("blank", "new"); var ignoreIDs = new Array("pdf"); var ignoreClass = new Array("nlb"); var fileExt; var hostname = window.location.hostname; var arrhostname = hostname.split("."); var domain = arrhostname[(arrhostname.length -2)] + "." + arrhostname[(arrhostname.length -1)] for (var x = 0; x < anchors.length; x++) { var h = anchors[x].href.toString(); var t = anchors[x].target.toLowerCase().replace("_", ""); var i = anchors[x].id.toLowerCase(); var c = anchors[x].className.toLowerCase(); var hostsubstridx = h.indexOf(domain+"/"); if(hostsubstridx > -1){ hostsubstridx += (domain+"/").length; h = h.substr(hostsubstridx,(h.length - hostsubstridx)); } var tmp = h.split("."); fileExt = tmp[(tmp.length - 1)]; if(ignoreIDs.indexOf(i) == -1 && ignoreClass.indexOf(c) == -1){ if (imgTypes.indexOf(fileExt) > -1 || (h.indexOf("~/media/") > -1 && fileExt == 'ashx')) { anchors[x].rel = 'lightbox'; anchors[x].target = ''; } } } $j('a[rel*=lightbox]').lightBox({ imageLoading:'/presentation/images/lightbox-ico-loading.gif', imageBtnClose:'/presentation/images/lightbox-btn-close.gif', imageBtnPrev:'/presentation/images/lightbox-btn-prev.gif', imageBtnNext:'/presentation/images/lightbox-btn-next.gif', imageBlank:'/presentation/images/lightbox-blank.gif' }); } $j(document).ready(function() { gInitLightbox(); $j("ul#subspecialty-menu-b li a[href$='/cardiology/acute-coronary-syndrome-resource-center'][class$='resource']").click(function () { _gaq.push(['_setAccount', 'UA-671605-73']); _gaq.push(['_trackEvent', 'AstraZeneca Resource Center', 'Access Link', 'Subspecialty Menu B']); }); }); </script>  <script type="text/javascript"> __compete_code = '16e6ba5f18f1b237ad91753264c4dc2c'; /* Set control variables below this line. */ </script> <script type="text/javascript" src="//web.archive.org/web/20130907150204js_/http://c.compete.com/bootstrap/s/16e6ba5f18f1b237ad91753264c4dc2c/healio-com/bootstrap.js"></script> <noscript> <img width="1" height="1" src="https://web.archive.org/web/20130907150204im_/https://ssl-healio-com-16e6ba.c-col.com/"/> </noscript> <script id="piescript" type="text/javascript"> $j(function () { if (window.PIE) { $j('#main-content.mtg').each(function () { PIE.attach(this); }); } }); </script> <span id="dbg"></span> <input name="api_info_target" type="hidden" id="api_info_target"/> <div id="dmdjscript"> <script type="text/javascript"> window.A8AJQ = jQuery.noConflict();</script> <script src="https://web.archive.org/web/20130907150204js_/http://50f7680153f6cba9e65f-a4a4842ad50f9edc1b98e79695b0495a.r26.cf1.rackcdn.com/dmd_api.js" type="text/javascript"></script> <script language="javascript" type="text/javascript"> window.A8AJQ(document).ready(function () { window._A8A.check_for_cookie(true); }); </script> </div> <script type="text/javascript"> if (!NREUMQ.f) {NREUMQ.f=function() {NREUMQ.push(["load",new Date().getTime()]);var e=document.createElement("script"); e.type="text/javascript"; e.src=(("http:"===document.location.protocol)?"http:":"https:") + "//" + "js-agent.newrelic.com/nr-100.js"; document.body.appendChild(e);if(NREUMQ.a)NREUMQ.a();};NREUMQ.a=window.onload;window.onload=NREUMQ.f;};NREUMQ.push(["nrfj","beacon-2.newrelic.com","d03feeacda","1851818","YAEAbEZTCkZZAExeWVlLI2tkHRRHXRBdWUJWEAtXWh0IVEEMTUNFGAwHWVhbCxpVBlxeVVYIQlVVRhZcQENPUlQXCANBW0cQG1kQSE8=",3,780,new Date().getTime(),"6A261B3E76A3DB39","","","",""]);</script></body> </html>

CINXE.COM

Simple fracture risk prediction tests as useful as FRAX | Endocrinology