CINXE.COM
Oncology Cell-Line Derived and Immuno-Oncology Models | Genesis Drug Discovery & Development
<!doctype html> <html lang="en"> <head> <meta charset="utf-8"> <meta name="viewport" content="width=device-width"> <title>Oncology Cell-Line Derived and Immuno-Oncology Models | Genesis Drug Discovery & Development</title> <meta name="Description" content="Genesis Drug Discovery & Development."> <link rel="apple-touch-icon" sizes="180x180" href="https://www.gd3services.com/images/favicons/apple-touch-icon.png"> <link rel="icon" type="image/png" sizes="32x32" href="https://www.gd3services.com/images/favicons/favicon-32x32.png"> <link rel="icon" type="image/png" sizes="16x16" href="https://www.gd3services.com/images/favicons/favicon-16x16.png"> <link rel="manifest" href="https://www.gd3services.com/images/favicons/site.webmanifest"> <link rel="mask-icon" href="https://www.gd3services.com/images/favicons/safari-pinned-tab.svg" color=""> <meta name="msapplication-TileColor" content="#"> <meta name="theme-color" content=""> <link rel="stylesheet" href="https://www.gd3services.com/css/style.css?v=1727423705"> <link rel="stylesheet" href="https://www.gd3services.com/css/interior.css?v=1726566580"> <link rel="stylesheet" href="https://www.genesisglobalgrp.com/mods/css/global_head.css"> <script>var $site = "https://www.gd3services.com", $page = "oncology-cell-line-derived-immuno-oncology-models", $template = "services", $mods = "https://www.genesisglobalgrp.com/mods/";</script> <script type="module">var body=document.querySelector("body");function show(b,c,a){document.querySelector(b).classList.toggle(c),null!==a&&a()}function lazyLoadImages(){for(var b=document.querySelectorAll(".preload"),c=new IntersectionObserver(function(d){for(var b=0;b<d.length;b++)if(!0===d[b].isIntersecting){var a=d[b].target,e=a.getAttribute("data-src"),f=a.getAttribute("data-srcset");null!==e&&(a.src=e),null!==f&&(a.srcset=f),a.classList.add("loaded"),c.unobserve(a)}}),a=0;a<b.length;a++)c.observe(b[a])}window.addEventListener("load",function(){body.classList.add("loaded"),window.show=show}),document.addEventListener("DOMContentLoaded",lazyLoadImages,!1);var inView=new IntersectionObserver(function(a){for(i=0;i<a.length;i++)!0===a[i].isIntersecting&&a[i].target.parentNode.classList.add("in-view")},{threshold:[1]});setTimeout(function(){Array.prototype.forEach.call(document.querySelectorAll(".viewBox"),function(a,b){inView.observe(a)})},500)</script> <script src="https://www.gd3services.com/js/site.js?v=1726566563" defer></script> <script src="https://www.genesisglobalgrp.com/mods/js/global_head.js" defer></script> <script src="https://www.genesisglobalgrp.com/mods/cros/js/main.js" defer></script> <script src="https://js.hs-scripts.com/7155805.js" defer></script> <!-- Google Tag Manager --> <script>(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer','GTM-MC48CV5M');</script> <!-- End Google Tag Manager --> </head> <body class="page-oncology-cell-line-derived-immuno-oncology-models temp-services spring" style="--mainColor: #6f1400; --subColor: #8d7c5e;"> <!-- Google Tag Manager (noscript) --> <noscript><iframe src='https://www.googletagmanager.com/ns.html?id=GTM-MC48CV5M' height='0' width='0' style='display:none;visibility:hidden'></iframe></noscript> <!-- End Google Tag Manager (noscript) --> <header class="ggg"> <div class="fixed"> <a href="https://www.genesisglobalgrp.com" class="parent_link"> <img class="mxHeight" src="https://www.genesisglobalgrp.com/mods/images/logo_ggg_member.png" alt="Genesis Global Group" width="359" height="36"> </a> <button class="show_divisions" onClick="showEle('#ggg_connect', 'expand', event)"> <span id="connect" class="social connect"></span> <span class="txt"></span> </button> </div> </header> <div id="ggg_connect" class=""> <div class="gc_top"> <div class="gc_select"> <button class="dlvl one" data-value="ggg_10">Investment Properties</button><button class="dlvl one" data-value="ggg_2">Hospitality</button><button class="dlvl one" data-value="ggg_3">Biotechnology</button><button class="dlvl one" data-value="ggg_4">Health</button><button class="dlvl one" data-value="ggg_5">Manufacturing & Distribution</button> </div> <span class="bg_circle"></span> </div> <div id="ggg_10" class="ggg_companies splide"> <div class="splide__track"> <ul class="splide__list div_comps"> <li class="splide__slide"> <a href="https://www.genesis-ip.com" target="_blank"> <img src="https://www.genesisglobalgrp.com/mods/images/logo_gip.png" alt="Genesis Investment Properties"> </a> </li> </ul> </div> </div> <div id="ggg_2" class="ggg_companies splide"> <div class="splide__track"> <ul class="splide__list div_comps"> <li class="splide__slide"> <a href="https://www.genesis-hospitality.com" target="_blank"> <img src="https://www.genesisglobalgrp.com/mods/images/logo_genesis_hospitality.png" alt="Genesis Hospitality"> </a> </li> <li class="splide__slide"> <a href="https://www.peacockinn.com" target="_blank"> <img src="https://www.genesisglobalgrp.com/mods/images/logo_peacockinn.png" alt="The Peacock Inn"> </a> </li> <li class="splide__slide"> <a href="https://www.peacockinn.com/restaurant/" target="_blank"> <img src="https://www.genesisglobalgrp.com/mods/images/logo_perch.png" alt="The Perch"> </a> </li> <li class="splide__slide"> <a href="https://www.washingtoncrossinginn.com" target="_blank"> <img src="https://www.genesisglobalgrp.com/mods/images/logo_wci.png" alt="Washington Crossing Inn"> </a> </li> <li class="splide__slide"> <a href="https://www.lambertvillestation.com" target="_blank"> <img src="https://www.genesisglobalgrp.com/mods/images/logo_lsi.png" alt="Lambertville Station Restaurant and Inn"> </a> </li> <li class="splide__slide"> <a href="https://www.yardleyinn.com" target="_blank"> <img src="https://www.genesisglobalgrp.com/mods/images/logo_yardley_inn.png" alt="The Yardley Inn"> </a> </li> <li class="splide__slide"> <a href="https://www.chezalicecafe.com" target="_blank"> <img src="https://www.genesisglobalgrp.com/mods/images/logo_chez_alice.png" alt="Chez Alice Patisserie"> </a> </li> <li class="splide__slide"> <a href="https://www.bread-boutique.com" target="_blank"> <img src="https://www.genesisglobalgrp.com/mods/images/logo_bread_boutique.svg" alt="Bread Boutique"> </a> </li> <li class="splide__slide"> <a href="https://www.proofpizzeria.com" target="_blank"> <img src="https://www.genesisglobalgrp.com/mods/images/logo_proof.png" alt="Proof"> </a> </li> <li class="splide__slide"> <a href="https://www.nassaudiner.com" target="_blank"> <img src="https://www.genesisglobalgrp.com/mods/images/logo_nassau_diner.png" alt="Nassau Diner"> </a> </li> </ul> </div> </div> <div id="ggg_3" class="ggg_companies splide"> <div class="splide__track"> <ul class="splide__list div_comps"> <li class="splide__slide"> <a href="https://www.genesisbiotechgroup.com" target="_blank"> <img src="https://www.genesisglobalgrp.com/mods/images/logo_gbg.png" alt="Genesis Biotechnology Group"> </a> </li> <li class="splide__slide"> <a href="https://www.oncoveda.com" target="_blank"> <img src="https://www.genesisglobalgrp.com/mods/images/logo_oncoveda.png" alt="Oncoveda"> </a> </li> <li class="splide__slide"> <a href="https://www.institute-metabolic-disorders.com" target="_blank"> <img src="https://www.genesisglobalgrp.com/mods/images/logo_imd.png" alt="Institute of Metabolic Disorders"> </a> </li> <li class="splide__slide"> <a href="https://www.ibr-genetics.com" target="_blank"> <img src="https://www.genesisglobalgrp.com/mods/images/logo_ibr.png" alt="Institute for Biomarker Research"> </a> </li> <li class="splide__slide"> <a href="https://www.immunoveda.com" target="_blank"> <img src="https://www.genesisglobalgrp.com/mods/images/logo_immunoveda.png" alt="Immunoveda"> </a> </li> <li class="splide__slide"> <a href="https://www.gd3services.com" target="_blank"> <img src="https://www.genesisglobalgrp.com/mods/images/logo_gd3.png" alt="Genesis Drug Discovery & Development"> </a> </li> <li class="splide__slide"> <a href="https://www.venenumbiodesign.com" target="_blank"> <img src="https://www.genesisglobalgrp.com/mods/images/logo_venenum.png" alt="VENENUM Biodesign"> </a> </li> <li class="splide__slide"> <a href="https://www.nedp.com" target="_blank"> <img src="https://www.genesisglobalgrp.com/mods/images/logo_nedp.png" alt="New England Discovery Partners"> </a> </li> <li class="splide__slide"> <a href="https://www.bioblocks.com" target="_blank"> <img src="https://www.genesisglobalgrp.com/mods/images/logo_bioblocks.png" alt="BioBlocks"> </a> </li> <li class="splide__slide"> <a href="https://www.organochem.net" target="_blank"> <img src="https://www.genesisglobalgrp.com/mods/images/logo_organochem.png" alt="Organochem"> </a> </li> <li class="splide__slide"> <a href="https://www.ianalytical.net" target="_blank"> <img src="https://www.genesisglobalgrp.com/mods/images/logo_ias.png" alt="Integrated Analytical Solutions, Inc."> </a> </li> <li class="splide__slide"> <a href="https://www.pharmoptima.com" target="_blank"> <img src="https://www.genesisglobalgrp.com/mods/images/logo_pharmoptima.png" alt="PharmOptima"> </a> </li> <li class="splide__slide"> <a href="https://www.ingeniodiagnostics.com" target="_blank"> <img src="https://www.genesisglobalgrp.com/mods/images/logo_ingenio.png" alt="Ingenio Diagnostics"> </a> </li> <li class="splide__slide"> <a href="https://www.nexuspharm.com" target="_blank"> <img src="https://www.genesisglobalgrp.com/mods/images/logo_nexuspharma.png" alt="NexusPharma"> </a> </li> <li class="splide__slide"> <a href="https://www.invivotek.com" target="_blank"> <img src="https://www.genesisglobalgrp.com/mods/images/logo_invivotek.png" alt="Invivotek"> </a> </li> <li class="splide__slide"> <a href="https://www.compbio.com" target="_blank"> <img src="https://www.genesisglobalgrp.com/mods/images/logo_cbi.png" alt="Comparative Biosciences, Inc."> </a> </li> <li class="splide__slide"> <a href="https://www.statkingconsulting.com" target="_blank"> <img src="https://www.genesisglobalgrp.com/mods/images/logo_statking.png" alt="STATKING Clinical Services"> </a> </li> <li class="splide__slide"> <a href="https://www.jssresearch.com" target="_blank"> <img src="https://www.genesisglobalgrp.com/mods/images/logo_jss.png" alt="JSS Medical Research"> </a> </li> <li class="splide__slide"> <a href="https://www.mdlab.com" target="_blank"> <img src="https://www.genesisglobalgrp.com/mods/images/logo_mdl.png" alt="Medical Diagnostic Laboratories"> </a> </li> <li class="splide__slide"> <a href="https://www.sunpathmdl.com" target="_blank"> <img src="https://www.genesisglobalgrp.com/mods/images/logo_sunpath.png" alt="SunPath-MDL"> </a> </li> <li class="splide__slide"> <a href="https://www.4path.com" target="_blank"> <img src="https://www.genesisglobalgrp.com/mods/images/logo_4path.png" alt="4path, Ltd."> </a> </li> </ul> </div> </div> <div id="ggg_4" class="ggg_companies splide"> <div class="splide__track"> <ul class="splide__list div_comps"> <li class="splide__slide"> <a href="https://www.montclairbreastcenter.com/partnership/" target="_blank"> <img src="https://www.genesisglobalgrp.com/mods/images/logo_genesis_health.png" alt="Genesis Health"> </a> </li> <li class="splide__slide"> <a href="https://www.montclairbreastcenter.com" target="_blank"> <img src="https://www.genesisglobalgrp.com/mods/images/logo_mbc.png" alt="Montclair Breast Center"> </a> </li> </ul> </div> </div> <div id="ggg_5" class="ggg_companies splide"> <div class="splide__track"> <ul class="splide__list div_comps"> <li class="splide__slide"> <a href="https://www.wwmponline.com" target="_blank"> <img src="https://www.genesisglobalgrp.com/mods/images/logo_manufacturing.png" alt="Genesis Manufacturing & Distribution"> </a> </li> <li class="splide__slide"> <a href="https://www.wwmponline.com" target="_blank"> <img src="https://www.genesisglobalgrp.com/mods/images/logo_wwls.png" alt="WorldWide Life Sciences Division"> </a> </li> <li class="splide__slide"> <a href="https://www.bioplastmfg.com" target="_blank"> <img src="https://www.genesisglobalgrp.com/mods/images/logo_bioplast.png" alt="Bioplast Manufacturing, L.L.C."> </a> </li> </ul> </div> </div> </div> <header class="header"> <a class="header_sublogo" href="https://www.gd3services.com/"> <div class="header_sublogo_wrap"> <img class="header_sublogo_img" alt="GD3 Services Logo" src="https://www.genesisglobalgrp.com/mods/images/logo_gd3.png" /> </div> </a> <a id="logo" class="header_logo" href="https://www.gd3services.com"> <img class="header_logo_img" alt="Pharm Optima Logo" src="https://www.genesisglobalgrp.com/mods/images/logo_gd3.png" /> </a> <div id="menu" class="nav_wrap"> <ul class="nav_menu nav_menu"> <li class=" parent"> <a href="https://www.gd3services.com/about/" class="nav_link"> <strong>About</strong> </a> <ul class="submenu"> <li class=""> <a href="https://www.gd3services.com/about/facilities/" class="sub_nav_link"> <strong>Facilities</strong> </a> <li class=""> <a href="https://www.gd3services.com/about/leadership/" class="sub_nav_link"> <strong>Leadership</strong> </a> <li class=""> <a href="https://www.gd3services.com/about/partnering/" class="sub_nav_link"> <strong>Partnering</strong> </a> </li> </ul> <li class=" parent active-parent"> <a href="https://www.gd3services.com/divisions/" class="nav_link"> <strong>Divisions</strong> </a> <ul class="submenu"> <li class=" parent"> <a href="https://www.gd3services.com/divisions/chemistry/" class="sub_nav_link"> <strong>Chemistry</strong> </a> <ul class="submenuEX"> <li class=" parent"> <a href="https://www.gd3services.com/divisions/chemistry/medicinal-chemistry/" class="sub_nav_link"> <strong>Medicinal Chemistry</strong> </a> <ul class="submenuEX"> <li class=""> <a href="https://www.gd3services.com/divisions/chemistry/medicinal-chemistry/early-stage-hit-to-lead/" class="sub_nav_link"> <strong>Early Stage: Hit-to-Lead</strong> </a> <li class=""> <a href="https://www.gd3services.com/divisions/chemistry/medicinal-chemistry/lead-optimization/" class="sub_nav_link"> <strong>Lead Optimization</strong> </a> <li class=""> <a href="https://www.gd3services.com/divisions/chemistry/medicinal-chemistry/eclips-compound-collection/" class="sub_nav_link"> <strong>ECLiPS Compound Collection</strong> </a> <li class=""> <a href="https://www.gd3services.com/divisions/chemistry/medicinal-chemistry/structure-based-drug-design-identification-and-characterization/" class="sub_nav_link"> <strong>Structure-Based Drug Design, Identification and Characterization</strong> </a> <li class=""> <a href="https://www.gd3services.com/divisions/chemistry/medicinal-chemistry/intellectual-property/" class="sub_nav_link"> <strong>Intellectual Property</strong> </a> </ul> <li class=" parent"> <a href="https://www.gd3services.com/divisions/chemistry/organic-synthesis/" class="sub_nav_link"> <strong>Organic Synthesis</strong> </a> <ul class="submenuEX"> <li class=""> <a href="https://www.gd3services.com/divisions/chemistry/organic-synthesis/asymmetric-synthesis/" class="sub_nav_link"> <strong>Asymmetric Synthesis</strong> </a> <li class=""> <a href="https://www.gd3services.com/divisions/chemistry/organic-synthesis/high-speed-synthesis-and-purification/" class="sub_nav_link"> <strong>High-Speed Synthesis and purification</strong> </a> <li class=""> <a href="https://www.gd3services.com/divisions/chemistry/organic-synthesis/metabolite-synthesis-phase-i-and-ii/" class="sub_nav_link"> <strong>Metabolite Synthesis (Phase I and II)</strong> </a> <li class=""> <a href="https://www.gd3services.com/divisions/chemistry/organic-synthesis/molecular-probes-fluorophores-and-biotinylated-targets/" class="sub_nav_link"> <strong>Molecular Probes (Fluorophores and Biotinylated Targets)</strong> </a> <li class=""> <a href="https://www.gd3services.com/divisions/chemistry/organic-synthesis/structure-identification-and-characterization/" class="sub_nav_link"> <strong>Structure Identification and Characterization</strong> </a> <li class=""> <a href="https://www.gd3services.com/divisions/chemistry/organic-synthesis/stable-isotopically-labeled-compounds/" class="sub_nav_link"> <strong>Stable Isotopically Labeled Compounds (2H, 13C, 15N, 34S)</strong> </a> <li class=""> <a href="https://www.gd3services.com/divisions/chemistry/organic-synthesis/specific-chemistry-expertise/" class="sub_nav_link"> <strong>Specific Chemistry Expertise</strong> </a> <li class=""> <a href="https://www.gd3services.com/divisions/chemistry/organic-synthesis/natural-product-synthesis/" class="sub_nav_link"> <strong>Natural Product Synthesis</strong> </a> <li class=""> <a href="https://www.gd3services.com/divisions/chemistry/organic-synthesis/instrumentation-and-computing/" class="sub_nav_link"> <strong>Instrumentation and Computing</strong> </a> </ul> <li class=" parent"> <a href="https://www.gd3services.com/divisions/chemistry/process-chemistry-large-scale-synthesis/" class="sub_nav_link"> <strong>Process Chemistry & Large Scale Synthesis</strong> </a> <ul class="submenuEX"> <li class=""> <a href="https://www.gd3services.com/divisions/chemistry/process-chemistry-large-scale-synthesis/synthetic-route-discovery/" class="sub_nav_link"> <strong>Synthetic Route Discovery</strong> </a> <li class=""> <a href="https://www.gd3services.com/divisions/chemistry/process-chemistry-large-scale-synthesis/process-optimization-for-api-synthesis/" class="sub_nav_link"> <strong>Process Optimization for API Synthesis</strong> </a> <li class=""> <a href="https://www.gd3services.com/divisions/chemistry/process-chemistry-large-scale-synthesis/api-specifications/" class="sub_nav_link"> <strong>API Specifications</strong> </a> <li class=""> <a href="https://www.gd3services.com/divisions/chemistry/process-chemistry-large-scale-synthesis/large-scale-synthesis/" class="sub_nav_link"> <strong>Large Scale Synthesis</strong> </a> <li class=""> <a href="https://www.gd3services.com/divisions/chemistry/process-chemistry-large-scale-synthesis/facilities-and-equipment/" class="sub_nav_link"> <strong>Facilities and Equipment</strong> </a> </ul> <li class=" parent"> <a href="https://www.gd3services.com/divisions/chemistry/analytical-chemistry-services-in-vitro-adme/" class="sub_nav_link"> <strong>Analytical Chemistry Services - <em>In vitro</em> ADME</strong> </a> <ul class="submenuEX"> <li class=""> <a href="https://www.gd3services.com/divisions/chemistry/analytical-chemistry-services-in-vitro-adme/nuclear-magnetic-resonance-spectroscopy-nmr/" class="sub_nav_link"> <strong>Nuclear Magnetic Resonance Spectroscopy (NMR)</strong> </a> <li class=""> <a href="https://www.gd3services.com/divisions/chemistry/analytical-chemistry-services-in-vitro-adme/high-performance-liquid-chromatography-hplc/" class="sub_nav_link"> <strong>High-performance liquid chromatography (HPLC)</strong> </a> <li class=""> <a href="https://www.gd3services.com/divisions/chemistry/analytical-chemistry-services-in-vitro-adme/liquid-chromatography-mass-spectrometry-lcms/" class="sub_nav_link"> <strong>Liquid Chromatography-Mass Spectrometry (LCMS)</strong> </a> <li class=""> <a href="https://www.gd3services.com/divisions/chemistry/analytical-chemistry-services-in-vitro-adme/gas-chromatography-mass-spectrometry-gcms/" class="sub_nav_link"> <strong>Gas Chromatography-Mass Spectrometry (GCMS)</strong> </a> <li class=""> <a href="https://www.gd3services.com/divisions/chemistry/analytical-chemistry-services-in-vitro-adme/small-molecule-x-ray-crystallography/" class="sub_nav_link"> <strong>Small Molecule X-ray Crystallography</strong> </a> </ul> <li class=""> <a href="https://www.gd3services.com/divisions/chemistry/compound-libraries-for-screening/" class="sub_nav_link"> <strong>Compound Libraries for Screening</strong> </a> <li class=" parent"> <a href="https://www.gd3services.com/divisions/chemistry/antibody-drug-conjugates/" class="sub_nav_link"> <strong>Antibody Drug Conjugates</strong> </a> <ul class="submenuEX"> <li class=""> <a href="https://www.gd3services.com/divisions/chemistry/antibody-drug-conjugates/bioconjugation/" class="sub_nav_link"> <strong>Bioconjugation</strong> </a> <li class=""> <a href="https://www.gd3services.com/divisions/chemistry/antibody-drug-conjugates/adc-process-research/" class="sub_nav_link"> <strong>ADC Process Research</strong> </a> <li class=""> <a href="https://www.gd3services.com/divisions/chemistry/antibody-drug-conjugates/purification-and-analytic-services/" class="sub_nav_link"> <strong>Purification and Analytic Services</strong> </a> <li class=""> <a href="https://www.gd3services.com/divisions/chemistry/antibody-drug-conjugates/design-and-synthesis-of-linker-payload/" class="sub_nav_link"> <strong>Design and Synthesis of Linker Payload</strong> </a> <li class=""> <a href="https://www.gd3services.com/divisions/chemistry/antibody-drug-conjugates/mechanism-of-action-of-antibody-drug-conjugates/" class="sub_nav_link"> <strong>Mechanism of Action of Antibody-Drug Conjugates</strong> </a> </ul> <li class=" parent"> <a href="https://www.gd3services.com/divisions/chemistry/case-studies/" class="sub_nav_link"> <strong>Case Studies</strong> </a> <ul class="submenuEX"> <li class=""> <a href="https://www.gd3services.com/divisions/chemistry/case-studies/arginase-inhibitors/" class="sub_nav_link"> <strong>Arginase inhibitors</strong> </a> <li class=""> <a href="https://www.gd3services.com/divisions/chemistry/case-studies/ironistat-b/" class="sub_nav_link"> <strong>Ironistat-B</strong> </a> <li class=""> <a href="https://www.gd3services.com/divisions/chemistry/case-studies/cocoa-flavinol-metabolites/" class="sub_nav_link"> <strong>Cocoa flavinol metabolites</strong> </a> <li class=""> <a href="https://www.gd3services.com/divisions/chemistry/case-studies/resolvin-e1-synthesis/" class="sub_nav_link"> <strong>Resolvin E1 synthesis</strong> </a> </ul> </ul> <li class=" parent"> <a href="https://www.gd3services.com/divisions/biochemistry-bioanalytical/" class="sub_nav_link"> <strong>Biochemistry & Bioanalytical</strong> </a> <ul class="submenuEX"> <li class=""> <a href="https://www.venenumbiodesign.com/" class="sub_nav_link"> <strong>Venenum Biodesign</strong> </a> <li class=""> <a href="https://www.ianalytical.net/" class="sub_nav_link"> <strong>IAS</strong> </a> <li class=""> <a href="https://www.pharmoptima.com/" class="sub_nav_link"> <strong>PharmOptima</strong> </a> <li class=""> <a href="https://www.ingeniodiagnostics.com/" class="sub_nav_link"> <strong>Ingenio Diagnostics</strong> </a> </ul> <li class=" parent active-parent"> <a href="https://www.gd3services.com/divisions/disease-modeling/" class="sub_nav_link"> <strong>Disease Modeling</strong> </a> <ul class="submenuEX"> <li class=" parent active-parent"> <a href="https://www.gd3services.com/divisions/disease-modeling/disease-models/" class="sub_nav_link"> <strong>Disease Models</strong> </a> <ul class="submenuEX"> <li class="active-page "> <a href="https://www.gd3services.com/divisions/disease-modeling/disease-models/oncology-cell-line-derived-immuno-oncology-models/" class="sub_nav_link"> <strong>Oncology Cell-Line Derived and Immuno-Oncology Models</strong> </a> <li class=""> <a href="https://www.gd3services.com/divisions/disease-modeling/disease-models/patient-derived-xenograft-models-pdx/" class="sub_nav_link"> <strong>Patient-Derived Xenograft Models (PDX)</strong> </a> <li class=""> <a href="https://www.gd3services.com/divisions/disease-modeling/disease-models/inflammation-autoimmune-models/" class="sub_nav_link"> <strong>Inflammation & Autoimmune Models</strong> </a> <li class=""> <a href="https://www.gd3services.com/divisions/disease-modeling/disease-models/metabolic-disease-obesity-diabetes-models/" class="sub_nav_link"> <strong>Metabolic Disease, Obesity & Diabetes Models</strong> </a> <li class=""> <a href="https://www.gd3services.com/divisions/disease-modeling/disease-models/behavioral-models/" class="sub_nav_link"> <strong>Behavioral Models</strong> </a> </ul> <li class=" parent"> <a href="https://www.gd3services.com/divisions/disease-modeling/assays/" class="sub_nav_link"> <strong><em>In Vitro, In Vivo, Ex Vivo</em> and ADME Assays</strong> </a> <ul class="submenuEX"> <li class=""> <a href="https://www.gd3services.com/divisions/disease-modeling/assays/in-vitro-assays/" class="sub_nav_link"> <strong><em>In Vitro</em> Assays</strong> </a> <li class=""> <a href="https://www.gd3services.com/divisions/disease-modeling/assays/in-vivo-assays/" class="sub_nav_link"> <strong><em>In Vivo</em> Assays</strong> </a> <li class=""> <a href="https://www.gd3services.com/divisions/disease-modeling/assays/ex-vivo-assays/" class="sub_nav_link"> <strong><em>Ex Vivo</em> Assays</strong> </a> <li class=""> <a href="https://www.gd3services.com/divisions/disease-modeling/assays/adme-assays/" class="sub_nav_link"> <strong>ADME Assays</strong> </a> </ul> <li class=" parent"> <a href="https://www.gd3services.com/divisions/disease-modeling/pk-pd-services/" class="sub_nav_link"> <strong>PK/PD Services</strong> </a> <ul class="submenuEX"> <li class=""> <a href="https://www.gd3services.com/divisions/disease-modeling/pk-pd-services/exposure-bioavailability/" class="sub_nav_link"> <strong>Exposure and Bioavailability</strong> </a> <li class=""> <a href="https://www.gd3services.com/divisions/disease-modeling/pk-pd-services/biodistribution/" class="sub_nav_link"> <strong>Biodistribution</strong> </a> <li class=""> <a href="https://www.gd3services.com/divisions/disease-modeling/pk-pd-services/mechanism-of-action-investigations/" class="sub_nav_link"> <strong>PD Biomarker and Mechanism of Action Investigations</strong> </a> <li class=""> <a href="https://www.gd3services.com/divisions/disease-modeling/pk-pd-services/dose-exposure-studies/" class="sub_nav_link"> <strong>Dose-Exposure and PK/PD Studies</strong> </a> </ul> <li class=" parent"> <a href="https://www.gd3services.com/divisions/disease-modeling/tolerability-toxicology/" class="sub_nav_link"> <strong>Tolerability and Toxicology</strong> </a> <ul class="submenuEX"> <li class=""> <a href="https://www.gd3services.com/divisions/disease-modeling/tolerability-toxicology/dose-range-finding-mtd-mabel-determination/" class="sub_nav_link"> <strong>Dose Range Finding, MTD and MABEL Determination</strong> </a> <li class=""> <a href="https://www.gd3services.com/divisions/disease-modeling/tolerability-toxicology/glp-non-glp-toxicology/" class="sub_nav_link"> <strong>GLP and Non-GLP Toxicology</strong> </a> </ul> <li class=" parent"> <a href="https://www.gd3services.com/divisions/disease-modeling/platforms-capabilities/" class="sub_nav_link"> <strong>Platforms and Capabilities</strong> </a> <ul class="submenuEX"> <li class=""> <a href="https://www.gd3services.com/divisions/disease-modeling/platforms-capabilities/humice/" class="sub_nav_link"> <strong>huMice</strong> </a> <li class=""> <a href="https://www.gd3services.com/divisions/disease-modeling/platforms-capabilities/sarrp/" class="sub_nav_link"> <strong>Small Animal Radiation Research Platform (SARRP)</strong> </a> <li class=""> <a href="https://www.gd3services.com/divisions/disease-modeling/platforms-capabilities/in-vivo-bioluminescence-fluorescence-imaging/" class="sub_nav_link"> <strong>Noninvasive <em>In Vivo</em> Bioluminescence/Fluorescence Imaging</strong> </a> <li class=""> <a href="https://www.gd3services.com/divisions/disease-modeling/platforms-capabilities/biomarker-core/" class="sub_nav_link"> <strong>Biomarker Core</strong> </a> <li class=""> <a href="https://www.gd3services.com/divisions/disease-modeling/platforms-capabilities/clinical-chemistry/" class="sub_nav_link"> <strong>Clinical Chemistry & Hematology</strong> </a> <li class=""> <a href="https://www.gd3services.com/divisions/disease-modeling/platforms-capabilities/phenotyping-gems/" class="sub_nav_link"> <strong>Phenotyping of Genetically Engineered Models (GEMS) </strong> </a> </ul> </ul> <li class=" parent"> <a href="https://www.gd3services.com/divisions/preclinical-toxicology/" class="sub_nav_link"> <strong>Preclinical-Toxicology</strong> </a> <ul class="submenuEX"> <li class=""> <a href="https://www.compbio.com/" class="sub_nav_link"> <strong>Comparative Biosciences, Inc.</strong> </a> </ul> <li class=" parent"> <a href="https://www.gd3services.com/divisions/clinical/" class="sub_nav_link"> <strong>Clinical</strong> </a> <ul class="submenuEX"> <li class=""> <a href="https://www.statkingconsulting.com/" class="sub_nav_link"> <strong>STATKING Clinical Services</strong> </a> <li class=""> <a href="https://www.jssresearch.com/" class="sub_nav_link"> <strong>JSS Medical Research</strong> </a> </ul> </li> </ul> <li class=" parent"> <a href="https://www.gd3services.com/news/" class="nav_link"> <strong>News</strong> </a> <ul class="submenu"> <li class=""> <a href="https://www.gd3services.com/news/publications/" class="sub_nav_link"> <strong>Publications</strong> </a> </li> </ul> <li class=" parent"> <a href="https://us241.dayforcehcm.com/CandidatePortal/en-US/ggg/SITE/GGGResearchCareerSite" class="nav_link"> <strong>Careers</strong> </a> <ul class="submenu"> <li class=""> <a href="https://www.gd3services.com/careers/culture/" class="sub_nav_link"> <strong>Culture</strong> </a> <li class=""> <a href="https://www.gd3services.com/careers/benefits/" class="sub_nav_link"> <strong>Benefits</strong> </a> <li class=""> <a href="https://www.gd3services.com/careers/internships/" class="sub_nav_link"> <strong>Internships</strong> </a> </li> </ul> <li class=""> <a href="https://www.gd3services.com/contact/" class="nav_link"> <strong>Contact</strong> </a> </li> </ul> <a class="login_btn disabled"> <svg version="1.2" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 25 27" width="25" height="27" fill="currentColor"> <path fill-rule="evenodd" class="a" d="m17.4 15.9q0.1 0 0.1 0 0.2-0.2 0.4-0.3 0.2-0.2 0.4-0.3 0 0 0-0.1 0.2-0.1 0.4-0.2 0-0.1 0-0.1 0.1-0.1 0.3-0.2 0-0.1 0-0.1 0.2-0.1 0.3-0.3 0 0 0.1-0.1 0.1-0.1 0.2-0.3 0 0 0.1-0.1 0-0.1 0.1-0.2 0.1 0 0.1-0.1 0.1-0.1 0.2-0.3 0-0.1 0.1-0.1 0-0.1 0.1-0.2 0-0.2 0.1-0.3 0-0.1 0.1-0.2 0-0.1 0-0.2 0.6-1.4 0.6-3.2c0-2.9-0.9-5.1-2.6-6.7-2.1-1.9-4.8-2.2-6-2.3q-0.1 0-0.3 0-0.3 0-0.3 0c-1.2 0.1-4 0.4-6.1 2.3-1.7 1.6-2.6 3.8-2.6 6.7 0 2.3 0.7 4.2 2.1 5.6 1.3-0.6 2.6-1 3.8-1.4-1.5-0.9-2.4-2.1-2.4-4.2q0-2.8 1.5-4.2c1.4-1.3 3.5-1.4 4-1.4 0.6 0 2.5 0.2 3.9 1.4q1.5 1.4 1.5 4.2c0 1.2-0.3 2.2-0.9 3q0 0 0 0-0.2 0.2-0.4 0.4 0 0.1-0.1 0.1-0.2 0.2-0.5 0.4 0 0 0 0-0.3 0.2-0.6 0.4 0 0 0 0-0.4 0.2-0.7 0.4 0 0-0.1 0-0.1 0.1-0.3 0.1 0 0 0 0.1-0.2 0-0.4 0.1 0 0-0.1 0-0.1 0.1-0.3 0.2 0 0-0.1 0-0.2 0.1-0.4 0.1 0 0.1-0.1 0.1-0.1 0-0.3 0.1 0 0-0.1 0-0.7 0.3-1.5 0.5c-1.1 0.4-2.3 0.7-3.4 1.2q-0.2 0.1-0.5 0.2 0 0 0 0-0.2 0.1-0.4 0.2-0.1 0-0.1 0-0.2 0.1-0.4 0.2 0 0-0.1 0-0.1 0.1-0.3 0.2-0.1 0-0.1 0.1-0.2 0.1-0.4 0.2 0 0-0.1 0-0.1 0.1-0.3 0.2-0.1 0.1-0.1 0.1-0.2 0.1-0.3 0.2-0.1 0.1-0.1 0.1-0.3 0.2-0.5 0.3c-2.4 2-3.6 4.7-3.6 8.4h3.5c0-5.5 3.1-6.7 8.3-8.3 1.8-0.6 3.6-1.2 5.2-2.1q0.2-0.2 0.4-0.3zm3.3 2.3q-0.7-0.5-1.4-0.9 0 0 0 0c-1.2 0.9-2.4 1.5-3.7 2 3.3 1.3 5.2 3 5.2 7.3h3.5c0-3.7-1.2-6.4-3.6-8.4z" /> </svg>Login or register </a> </div> <button type="button" id="toggle-mob-search" class="search_topics"></button> <button type="button" id="menu_open" class="nav_mob_menu_open" onclick="toggleAttr('#menu', 'visible');toggleAttr('#menu_open', 'cross');toggleAttr('#logo', 'hide')"> <span></span> <span></span> <span></span> </button> </header> <script> var $divisions = [{"name":"Chemistry","icon":"chemistry.svg","page":"chemistry","subnav":[{"name":"Medicinal Chemistry","page":"medicinal-chemistry","subnav":[{"name":"Early Stage: Hit-to-Lead","page":"early-stage-hit-to-lead"},{"name":"Lead Optimization","page":"lead-optimization"},{"name":"ECLiPS Compound Collection","page":"eclips-compound-collection"},{"name":"Structure-Based Drug Design, Identification and Characterization","page":"structure-based-drug-design-identification-and-characterization"},{"name":"Intellectual Property","page":"intellectual-property","links":[{"name":"Organic Synthesis","page":"organic-synthesis"}]}]},{"name":"Organic Synthesis","page":"organic-synthesis","subnav":[{"name":"Asymmetric Synthesis","page":"asymmetric-synthesis"},{"name":"High-Speed Synthesis and purification","page":"high-speed-synthesis-and-purification"},{"name":"Metabolite Synthesis (Phase I and II)","page":"metabolite-synthesis-phase-i-and-ii"},{"name":"Molecular Probes (Fluorophores and Biotinylated Targets)","page":"molecular-probes-fluorophores-and-biotinylated-targets"},{"name":"Structure Identification and Characterization","page":"structure-identification-and-characterization"},{"name":"Stable Isotopically Labeled Compounds (2H, 13C, 15N, 34S)","page":"stable-isotopically-labeled-compounds"},{"name":"Specific Chemistry Expertise","page":"specific-chemistry-expertise"},{"name":"Natural Product Synthesis","page":"natural-product-synthesis"},{"name":"Instrumentation and Computing","page":"instrumentation-and-computing"}]},{"name":"Process Chemistry & Large Scale Synthesis","page":"process-chemistry-large-scale-synthesis","subnav":[{"name":"Synthetic Route Discovery","page":"synthetic-route-discovery"},{"name":"Process Optimization for API Synthesis","page":"process-optimization-for-api-synthesis"},{"name":"API Specifications","page":"api-specifications"},{"name":"Large Scale Synthesis","page":"large-scale-synthesis"},{"name":"Facilities and Equipment","page":"facilities-and-equipment"}]},{"name":"Analytical Chemistry Services - <em>In vitro</em> ADME","page":"analytical-chemistry-services-in-vitro-adme","subnav":[{"name":"Nuclear Magnetic Resonance Spectroscopy (NMR)","page":"nuclear-magnetic-resonance-spectroscopy-nmr"},{"name":"High-performance liquid chromatography (HPLC)","page":"high-performance-liquid-chromatography-hplc"},{"name":"Liquid Chromatography-Mass Spectrometry (LCMS)","page":"liquid-chromatography-mass-spectrometry-lcms"},{"name":"Gas Chromatography-Mass Spectrometry (GCMS)","page":"gas-chromatography-mass-spectrometry-gcms"},{"name":"Small Molecule X-ray Crystallography","page":"small-molecule-x-ray-crystallography"}]},{"name":"Compound Libraries for Screening","page":"compound-libraries-for-screening"},{"name":"Antibody Drug Conjugates","page":"antibody-drug-conjugates","subnav":[{"name":"Bioconjugation","page":"bioconjugation"},{"name":"ADC Process Research","page":"adc-process-research"},{"name":"Purification and Analytic Services","page":"purification-and-analytic-services"},{"name":"Design and Synthesis of Linker Payload","page":"design-and-synthesis-of-linker-payload"},{"name":"Mechanism of Action of Antibody-Drug Conjugates","page":"mechanism-of-action-of-antibody-drug-conjugates"}]},{"name":"Case Studies","page":"case-studies","subnav":[{"name":"Arginase inhibitors","page":"arginase-inhibitors"},{"name":"Ironistat-B","page":"ironistat-b"},{"name":"Cocoa flavinol metabolites","page":"cocoa-flavinol-metabolites"},{"name":"Resolvin E1 synthesis","page":"resolvin-e1-synthesis"}]}]},{"name":"Biochemistry & Bioanalytical","icon":"bio.svg","page":"biochemistry-bioanalytical","subnav":[{"name":"Venenum Biodesign","page":"https://www.venenumbiodesign.com/","href":"https://www.venenumbiodesign.com/"},{"name":"IAS","page":"https://www.ianalytical.net/","href":"https://www.ianalytical.net/"},{"name":"PharmOptima","page":"https://www.pharmoptima.com/","href":"https://www.pharmoptima.com/"},{"name":"Ingenio Diagnostics","page":"https://www.ingeniodiagnostics.com/","href":"https://www.ingeniodiagnostics.com/"}]},{"name":"Disease Modeling","icon":"disease.svg","page":"disease-modeling","subnav":[{"name":"Disease Models","page":"disease-models","subnav":[{"name":"Oncology Cell-Line Derived and Immuno-Oncology Models","page":"oncology-cell-line-derived-immuno-oncology-models"},{"name":"Patient-Derived Xenograft Models (PDX)","page":"patient-derived-xenograft-models-pdx","js":"loader"},{"name":"Inflammation & Autoimmune Models","page":"inflammation-autoimmune-models"},{"name":"Metabolic Disease, Obesity & Diabetes Models","page":"metabolic-disease-obesity-diabetes-models"},{"name":"Behavioral Models","page":"behavioral-models"}]},{"name":"<em>In Vitro, In Vivo, Ex Vivo</em> and ADME Assays","page":"assays","subnav":[{"name":"<em>In Vitro</em> Assays","page":"in-vitro-assays"},{"name":"<em>In Vivo</em> Assays","page":"in-vivo-assays"},{"name":"<em>Ex Vivo</em> Assays","page":"ex-vivo-assays"},{"name":"ADME Assays","page":"adme-assays"}]},{"name":"PK/PD Services","page":"pk-pd-services","subnav":[{"name":"Exposure and Bioavailability","page":"exposure-bioavailability"},{"name":"Biodistribution","page":"biodistribution"},{"name":"PD Biomarker and Mechanism of Action Investigations","page":"mechanism-of-action-investigations"},{"name":"Dose-Exposure and PK/PD Studies","page":"dose-exposure-studies"}]},{"name":"Tolerability and Toxicology","page":"tolerability-toxicology","subnav":[{"name":"Dose Range Finding, MTD and MABEL Determination","page":"dose-range-finding-mtd-mabel-determination"},{"name":"GLP and Non-GLP Toxicology","page":"glp-non-glp-toxicology"}]},{"name":"Platforms and Capabilities","page":"platforms-capabilities","subnav":[{"name":"huMice","page":"humice","js":"loader"},{"name":"Small Animal Radiation Research Platform (SARRP)","page":"sarrp","js":"loader"},{"name":"Noninvasive <em>In Vivo</em> Bioluminescence/Fluorescence Imaging","page":"in-vivo-bioluminescence-fluorescence-imaging"},{"name":"Biomarker Core","page":"biomarker-core"},{"name":"Clinical Chemistry & Hematology","page":"clinical-chemistry"},{"name":"Phenotyping of Genetically Engineered Models (GEMS) ","page":"phenotyping-gems"}]}]},{"name":"Preclinical-Toxicology","icon":"toxicology.svg","page":"preclinical-toxicology","subnav":[{"name":"Comparative Biosciences, Inc.","page":"https://www.compbio.com/","href":"https://www.compbio.com/"}]},{"name":"Clinical","icon":"clinical-trials.svg","page":"clinical","subnav":[{"name":"STATKING Clinical Services","page":"https://www.statkingconsulting.com/","href":"https://www.statkingconsulting.com/"},{"name":"JSS Medical Research","page":"https://www.jssresearch.com/","href":"https://www.jssresearch.com/"}]}]; </script> <main id="content" > <div class="search_gd3_bar"> <div class="search_pill"> <div class="topic_dropdown"> <button type="button" id="topics_btn" onclick="show_element('topics_dd', 'show')"> <span>Topics</span> </button> <ul id="topics_dd" class="drop_down toggle" onclick="show_element('topics_dd', 'show')"> <li> <button type="button"> <span class="drop_down_span">ADC</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">ADC Purification</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">ADC Synthesis</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">Antibody Drug Conjugate</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">Antibody Drug Conjugates</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">BRCA</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">Bioanalytical Services</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">Bioconjugation</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">Biosimilars</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">Bladder Cancer</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">Breast Cancer</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">CAR-T</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">Cancer Treatment</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">Clinical Trial Management Ind</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">Colon Cancer</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">Companion Diagnostics</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">Custom Synthesis</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">DMPK</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">Diabetes</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">Diabetes Animal Model</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">Efficacy</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">Fatty Liver</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">Fibrosis</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">HBOC</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">IHC</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">Immunofluorescence</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">Immunohistochemistry</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">Immunohistochemisty</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">Linker Payload</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">Lymphoma</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">Lynch Syndrome</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">Medicinal Chemistry</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">NASH</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">Organic Synthesis</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">PK/PD</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">Pharmacodynamics</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">Pharmacogenomics</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">Pharmacokinetics</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">Pharmacokinetics/Pharmacodynamics</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">Prostate Cancer</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">Radiopharmaceutical</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">Rare Diseases</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">Retinopathy</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">STZ</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">Small Molecule Synthesis</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">Small Molecules</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">Special Staining</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">Streptozotocin</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">Syngeneic</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">TCR</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">Tissue Cross Reactivity</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">Tool Compound Synthesis</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">Toxicology</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">Xenograft</span> </button> </li> <li> <button type="button"> <span class="drop_down_span">Xenograft Mouse Tumor Model</span> </button> </li> </ul> </div> <div class="search_field"> <input type="search" id="search_gd3_field" placeholder="Search GD3 Services" value=""> </div> <button type="button" id="gd3_search" class="search_topics"></button> </div> <div id="gd3_overlay"> <section class="gd3o_box"> <div class="logo_tunnel"> <img src="https://www.genesisglobalgrp.com/mods/images/logo_gd3.png" alt="Genesis Drug Discovery & Development" class="current_site"> <div class="tunnel_tie"> <span></span> <span></span> <span></span> </div> <img src="https://www.genesisglobalgrp.com/mods/images/logo_gd3.png" alt="GD3" width="109" height="65" class="target_site"> </div> <h4>You will now be redirected to the GD<sup>3</sup> website</h4> <p>Genesis Drug Discovery & Development is a proud member of Genesis Drug Discovery & Development (GD3), a fully integrated CRO providing services to support drug discovery programs of our clients from target discovery through IND filing and managing Phase I-III clinical trials.</p> <a href="https://www.gd3services.com/members/" target="_blank" class="about_gd3">Learn more about GD<sup>3</sup></a> <div class="gd3o_btns"> <button type="button" id="gd3_search_cancel" onClick="show_element('gd3_overlay', 'show')"> <span>Cancel</span> </button> <a href="https://gd3services.com/search?site=Genesis Drug Discovery & Development" class="gd3_link btn"> <strong>Search</strong> </a> </div> </section> </div> <style type="text/css"> .learn_gd3 { display: block; text-align: center; padding-top: .5em; } .learn_gd3 img { display:inline-block; vertical-align: middle; margin-left: .3em; } .learn_gd3 span { vertical-align: middle; } #gd3_overlay { position: fixed; left:0; top:0; height: 100vh; width: 100%; background: rgba(0,0,0,.5); z-index: 10000; display: flex; justify-content: center; align-items: center; opacity: 0; pointer-events: none; transition: opacity .3s linear; -webkit-backdrop-filter: blur(3px); backdrop-filter: blur(3px); } #gd3_overlay.show { opacity: 1; pointer-events: all;} .gd3o_box { background: #fff; border-radius: 1em; padding: 1.5em 3%; max-width: 50em; text-align: center; box-shadow: 0 0 2em rgba(0,0,0,.15); transform: scale(.3); transition: transform .4s; } .show > .gd3o_box { transform: scale(1); transition-delay: .1s; } .logo_tunnel { display: flex; justify-content: center; align-items: center; padding-bottom: 2em; } .gd3o_box h4 { color: #101010; font-size: 1.4em; padding-bottom: 1em; margin: 0; } .gd3o_box p { font-size: .813em; margin: 0 auto 1.5em; color: #2f2f2f; line-height: 1.5em; max-width: 34em; text-align: justify; } .gd3o_btns { display: flex; justify-content: space-around; flex-wrap: wrap; padding: 2em 0 0; } .about_gd3 { text-decoration: underline; color: var(--mainColor);} .current_site { max-width: 12em; max-height: 4.5em; margin-right: 1.5em; animation: logos 2s linear infinite} .target_site { margin-left: .5em; animation: logos 2s .6s linear infinite} .tunnel_tie { display: flex; } .tunnel_tie > span { border-radius: 50%; width: .6em; height: .6em; margin: 0 1em 0 0; animation: circle_line 2s .2s steps(5) infinite} .tunnel_tie > span:nth-child(2) { animation-delay: .4s;} .tunnel_tie > span:last-child{ animation-delay: .6s;} @keyframes circle_line { 0% { background: var(--mainColor); } 25%, 50%, 75%, 100% { background: #c8c8c8; } } @keyframes logos { 0%, 20% { filter:grayscale(0%)} 22%, 100% {filter:grayscale(100%) } } #gd3_search_cancel { border: 2px solid #c8c8c8; border-radius: 2em; height: 3em; padding: 0 2em; color: #101010; background: #fff; } #gd3_search_cancel:hover { color: var(--mainColor); } .btn.gd3_link { margin: 0; } </style> <script> window.addEventListener("load", function(){ var btn = document.getElementById('gd3_search'), topics_btn = document.getElementById('topics_btn'), sfield = document.getElementById('search_gd3_field'), gd3_link = document.querySelector('.gd3_link'); //add overlay to body let overlay_html = document.getElementById('gd3_overlay'), fragment = document.createDocumentFragment(); //add overlay to temp fragment fragment.appendChild(overlay_html); //add to body document.querySelector('body').prepend(overlay_html); btn.addEventListener('click', function(){ //searchGD3(); overlay_html.classList.add('show'); }); gd3_link.addEventListener('click', function(){ searchGD3(); }); sfield.addEventListener('keypress', function (e) { if (e.key === 'Enter') { overlay_html.classList.add('show'); } }); function searchGD3(){ var href = gd3_link.getAttribute('href'); event.preventDefault(); if(sfield !== ''){ window.location = href + '&search=' + sfield.value; } } //topics var topics = document.querySelectorAll('#topics_dd button'); Array.prototype.forEach.call(topics, function(el, i){ el.addEventListener('click', function(){ var searchTerm = el.querySelector('span').innerHTML; document.getElementById('search_gd3_field').setAttribute('value', searchTerm); }); }); }); function show_element(ele, cla){ var el = document.getElementById(ele); el.classList.toggle(cla); } </script> </div> <div class="spacer"></div> <section class="main"> <div class="container_wide"> <div class="page_heading_wrap"> <h1 class="page_heading">Disease Modeling</h1> </div> <section class="info info-nav-wrapper "> <div class="info-nav_wrap"> <button class="info-nav_btn _left"></button> <ul class="info-nav"> <li class="info-nav_link _active"> <a href="https://www.gd3services.com/divisions/disease-modeling/disease-models/">Disease Models</a> </li> <li class="info-nav_link "> <a href="https://www.gd3services.com/divisions/disease-modeling/assays/"><em>In Vitro, In Vivo, Ex Vivo</em> and ADME Assays</a> </li> <li class="info-nav_link "> <a href="https://www.gd3services.com/divisions/disease-modeling/pk-pd-services/">PK/PD Services</a> </li> <li class="info-nav_link "> <a href="https://www.gd3services.com/divisions/disease-modeling/tolerability-toxicology/">Tolerability and Toxicology</a> </li> <li class="info-nav_link "> <a href="https://www.gd3services.com/divisions/disease-modeling/platforms-capabilities/">Platforms and Capabilities</a> </li> </ul> <button class="info-nav_btn _right"></button> </div> <div class="info_bg_wrap"> <div class="info_bg"></div> <div class="info_bg"></div> </div> </section> <section class="info info-nav-wrapper secondary"> <div class="info-nav_wrap"> <button class="info-nav_btn _left"></button> <ul class="info-nav"> <li class="info-nav_link _active"> <a href="https://www.gd3services.com/divisions/disease-modeling/disease-models/oncology-cell-line-derived-immuno-oncology-models/">Oncology Cell-Line Derived and Immuno-Oncology Models</a> </li> <li class="info-nav_link "> <a href="https://www.gd3services.com/divisions/disease-modeling/disease-models/patient-derived-xenograft-models-pdx/">Patient-Derived Xenograft Models (PDX)</a> </li> <li class="info-nav_link "> <a href="https://www.gd3services.com/divisions/disease-modeling/disease-models/inflammation-autoimmune-models/">Inflammation & Autoimmune Models</a> </li> <li class="info-nav_link "> <a href="https://www.gd3services.com/divisions/disease-modeling/disease-models/metabolic-disease-obesity-diabetes-models/">Metabolic Disease, Obesity & Diabetes Models</a> </li> <li class="info-nav_link "> <a href="https://www.gd3services.com/divisions/disease-modeling/disease-models/behavioral-models/">Behavioral Models</a> </li> </ul> <button class="info-nav_btn _right"></button> </div> </section> <div class="cta_wrapper"> <div class="cta"> <a href="https://www.gd3services.com/contact/" class="cta_btn"> <img class="cta_img" src="https://www.genesisglobalgrp.com/mods/cros/images/callout-img.png"> <div class="cta_main"> <div class="cta_text">Contact our Experts</div> </div> <div class="cta_dec"> <span></span> </div> </a> </div> </div> <section class="info overview _cdx"> <div class="overview_body"> <div class="overview_col"> <h1 class="info_title">Oncology Cell Line-Derived and Immuno-Oncology Models</h1> <p class="info_text">Our oncology program for evaluating test compounds in cell line-derived (CDX), mouse syngeneic, and in humanized (huMice) models offers a unique suite of technologies, scientific expertise, and technical skills for monitoring the effect of your therapeutics on primary and metastatic tumor growth in vivo. Specifically tailored, individual study designs are optimized to meet your needs. Interpretive data analysis and robust summary reports are provided upon completion of each study. GD<sup>3</sup>'s oncology and immuno-oncology disease models facilitate the translation of preclinical findings into clinically effective therapies for cancer patients. For information on our PDX models, please <a href="https://www.gd3services.com/divisions/disease-modeling/disease-models/patient-derived-xenograft-models-pdx/">click here</a>.</p> </div> </div> <div class="overview_body"> <div class="overview_col"> <h2 class="info_title _secondary">Types of Oncology and Immuno-Oncology Studies:</h2> <ul class="list _cols"> <li class="list-item">Efficacy studies in all models</li> <li class="list-item">Subcutaneous, orthotopic or disseminated models</li> <li class="list-item">Tolerability, toxicology, PK, PD, response and MOA investigations</li> <li class="list-item">Radiation treatment</li> <li class="list-item">Immunotherapy assessments in syngeneic models or humanized mice</li> <li class="list-item">Combination treatment studies</li> </ul> <h2 class="info_title _secondary">Our capabilities include:</h2> <ul class="list _cols"> <li class="list-item">Extensive experience in the fields of oncology and immuno-oncology</li> <li class="list-item">Sophisticated surgery techniques for orthotopic tumor implantation and primary tumor excision</li> <li class="list-item">Experience with xenograft tumor models in humanized mice</li> <li class="list-item">Expertise in noninvasive bioluminescence imaging for tracking orthotopic and metastatic tumor growth</li> <li class="list-item">Testing therapeutics in combination with targeted radiotherapy using our small animal radiation research platform</li> <li class="list-item">Biomarker analysis of tumor, lymphoid tissues and blood</li> <ul class="list _second"> <li class="list-item">Multiplex analyses of cytokines, hormones, and other analytes</li> <li class="list-item">Flow cytometry analysis of tumor-infiltrating lymphocytes</li> <li class="list-item">Gene expression analysis by PCR and RT-qPCR</li> </ul> </ul> </div> <div class="overview_col"> <img class="info_img" src="https://www.gd3services.com/images/cdx.jpg?v=1722605225" /> </div> </div> <div class="overview_body"> <ul class="accord _headings"> <li class="accord_el _active"> <button class="accord_btn">Human Cell-Derived Xenografts (CDX) and Murine Syngeneic Models</button> <div class="accord_content"> <p class="info_text">GD<sup>3</sup> has a growing biobank of murine syngeneic and human cancer-derived cell line models. These cell lines can be implanted as orthotopic, subcutaneous, metastatic, or disseminated models. Human CDX models are valuable, well-characterized, preclinical tools for assessing the efficacy, safety, and mechanisms of action of cancer therapeutics. In murine syngeneic models, cancer cell lines derived from a specific mouse strain are implanted into immunocompetent mice of the same strain. This allows tumor growth to occur in the presence of a genetically matched, functional immune system and can be used to simulate the tumor microenvironment and immune response to develop novel immuno-oncology treatments that leverage the immune system to combat cancer.</p> <p class="info_text">Our well-characterized CDX and murine syngeneic models include, but are not limited to, bladder, lung, breast, colon, kidney, myeloid leukemia, mesothelioma, ovarian, myoblast, prostate, melanoma, lymphoblast, brain, cervical, pancreatic and other cancers.</p> </div> </li> <li class="accord_el"> <button class="accord_btn">huMice Immuno-Oncology Models</button> <div class="accord_content"> <p class="info_text">Humanized mice are immunodeficient mice in which the human immune system is partially reconstituted. This enables the investigation of agents that target proteins that do not have a close mouse orthologue and so cannot be studied in syngeneic mouse models. In these instances, reconstituting a human immune system within a mouse can provide a suitable preclinical model to evaluate immuno-oncology therapeutics. Our preferred model is to inoculate CD34+ human stem cells into immunodeficient mice after irradiation to generate niches for human immune cell engraftment. For efficacy studies, we follow engraftment success by flow cytometric analysis to confirm the presence and level of human immune cells prior to inoculation with tumor cells. In addition, we can also regenerate aspects of the human immune system by engrafting human PBMCs from preferred donors.</p> </div> </li> </ul> </div> <div class="overview_body"> <p data-division="disease-modeling" data-service="disease-models" data-subservice="oncology-cell-line-derived-immuno-oncology-models" class="info_text _links populate">Learn more about <span data-order="1"></span></p> </div> </section> </div> </section> </main> <div id="modal"> <!--<div id="redirect-modal" class="modal_overlay"> <div class="modal _redirect"> <span class="modal_icon"></span> <p class="modal_text">You are about to be redirected to an external website</p> <div class="modal_row"> <button id="modal-close" class="btn">Cancel</button> <a href="" class="btn _submit">Continue</a> </div> </div> </div>--> <div id="optin-modal" class="modal_overlay"> <div class="modal _optin"> <span class="modal_icon"></span> <p class="modal_text">Before you download, please fill out some info so we can discuss our services with you</p> <div class="modal_body"> <form class="form specific" data-sth="downloads"> <div class="form_msg"> <p class="status">Thank you for your message!</p> </div> <div class="field required"> <input placeholder="Optional" class="if" type="text" name="d_name" required /> <label for="last-name">Name</label> </div> <div class="field required"> <input placeholder="Optional" class="if" type="email" name="d_email" required /> <label for="email">Email</label> </div> <div class="field"> <input placeholder="Optional" class="if" type="number" name="d_phone" /> <label for="phone">Phone</label> </div> <input type="hidden" name="link"> <input type="hidden" name="key_code" value="a58e776747f150c8d4be65c9f039934e"> <input type="hidden" class="timer" name="timer" value=""> <label style="display: block;height:0;"> <input type="text" name="catch" style="height: 100%; border:0; padding:0;"> </label> <div class="modal_row"> <button id="modal-close" type="button" class="btn">Cancel</button> <div> <a href="" class="btn _submit">Skip</a> <button type="submit" class="btn _submit">Continue</button> </div> </div> </form> </div> </div> </div> </div> <footer class="footer"> <div class="footer_bg in_view_check"> <div class="footer_content"> <div class="footer_container container"> <div class="footer_info"> <div class="footer_info_wrap"> <img class="footer_info_img" alt="Icon Map" src="https://www.genesisglobalgrp.com/mods/cros/images/icon-map.svg" /> </div> <span class="footer_info_text">2439 Kuser Road<br>Hamilton, NJ 08690</span> </div> <div class="footer_info"> <div class="footer_info_wrap"> <img class="footer_info_img" alt="Icon Phone" src="https://www.genesisglobalgrp.com/mods/cros/images/icon-phone.svg" /> </div> <span class="footer_info_text _strong"> 609-528-6850<br> </span> </div> <a class="footer_info" href="https://www.linkedin.com/company/gd3services"> <div class="footer_info_wrap"> <img class="footer_info_img _lin" alt="LinkedIn Logo" src="https://www.genesisglobalgrp.com/mods/cros/images/logo-linkedin.png" /> </div> <span class="footer_info_text _strong">Our LinkedIn</span> </a> </div> </div> </div> <div class="subfooter in_view_check"> <div class="subfooter_content container"> <div class="subfooter_links"> <a class="subfooter_text" href="https://www.gd3services.com/terms/">Terms of Use</a> <a class="subfooter_text" href="https://www.gd3services.com/privacy/">Privacy Policy</a> </div> <p class="subfooter_text">©2024 Genesis Drug Discovery & Development, All Rights Reserved.</p> </div> </div> </footer> </body> </html>