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<!DOCTYPE html><html lang="en"><head> <link rel=preload href="https://assets.healthline.com/_next/vendor-c9e4f-legacy.js" as=script crossorigin=anonymous><link rel=preload href="https://assets.healthline.com/_next/lib-24e6f-legacy.js" as=script crossorigin=anonymous><link rel=preload href="https://assets.healthline.com/_next/felib-core-f46c4-legacy.js" as=script crossorigin=anonymous><link rel=preload href="https://assets.healthline.com/_next/d60d1f56-068d-41e0-978f-3a1db44d7851/hl/pages/infinite.js-legacy.js" as=script crossorigin=anonymous> <title>Progestin vs Progesterone: Are They the Same Thing? </title><link rel="canonical" href="https://www.healthline.com/health/womens-health/progestin-vs-progesterone"/><meta name="description" content="Yes and no, progestin is a synthetic version of progesterone. Both of them have uses in a variety of treatments: "/><meta name="keywords" content="progestin vs progesterone"/><meta name="k1" content="birthcontrol"/><meta name="k2" content="fertility"/><meta name="ROBOTS" content="NOODP"/><meta name="sailthru.image.thumb" content="https://media.post.rvohealth.io/wp-content/uploads/2022/02/birth-contorol-pack-with-rainbow-732-549-feature-thumb-732x549.jpg"/><meta name="sailthru.tags" content="birthcontrol,fertility"/><meta name="article:published_time" content="2022-07-18T07:53:57.000Z"/><meta name="article:author" content="Erica Cirino"/><meta property="og:title" content="Are Progesterone and Progestin the Same Thing? "/><meta property="og:description" content="Yes and no. Progestin is actually a man-made version of progesterone. Both of them have a variety of uses in regulating the human body, let's discuss: "/><meta property="og:type" content="article"/><meta property="og:url" content="https://www.healthline.com/health/womens-health/progestin-vs-progesterone"/><meta name="twitter:title" content="Progestin vs Progesterone: Are They the Same Thing? "/><meta name="twitter:description" content="Yes and no, progestin is a synthetic version of progesterone. 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data-testid="mobile-leaderboard" class="css-pdceuf"><div class="css-11egx89"><button class="icon-hl-close-thick css-16m9poz"></button><div data-empty="true" class="css-1fteite"><div class="css-1hjaa0k"><span class="css-zya54r"></span></div><div id="mlb1__slot" data-adbridg-ad-class="mlb1" data-ad="true" class="css-bcus5s"></div></div></div></aside><div data-placement="subheader"></div><div><div class="css-m260rd"><div data-article-body="0" class="css-blwnmv"><div class="css-z468a2"><h1>Your Guide to Progestin, Progesterone, and Their Roles</h1><div data-preamp="social-proof-lessons"></div><div data-testid="byline"><section data-testid="byline" class="css-jy1umg"><div class="css-1q67gt9"><div class="css-quwpxp"><img src="//i0.wp.com/post.healthline.com/wp-content/uploads/2022/01/Stacy-Henigsman-500x500-Bio.png?w=105&h=105" alt=""/></div></div><div><span><span><a class="css-1c2ok3c css-ro87dg" target="_blank" rel="noopener noreferrer">Medically reviewed</a> by <a class="css-1c2ok3c css-ro87dg" target="_blank" rel="noopener noreferrer">Stacy A. Henigsman, DO</a></span></span> — <span><span><span><span>Written by <a class="css-1c2ok3c css-ro87dg" target="_blank" rel="noopener noreferrer">Erica Cirino</a></span></span></span></span> <span> on July 18, 2022</span></div></section></div><div><nav id="tab-bar-0" data-testid="tab-bar" class="css-7u7i0a"><ul class="css-17ztj4b"><li class="css-t753mo"><a href="#similarity" class="css-1r1p1p8">Similarity</a></li><li class="css-t753mo"><a href="#functions" class="css-1r1p1p8">Functions</a></li><li class="css-t753mo"><a href="#differences" class="css-1r1p1p8">Differences</a></li><li class="css-t753mo"><a href="#safety" class="css-1r1p1p8">Safety </a></li><li class="css-t753mo"><a href="#treatments" class="css-1r1p1p8">Treatments</a></li><li class="css-t753mo"><a href="#takeaway" class="css-1r1p1p8">Takeaway</a></li></ul></nav><article class="article-body css-d2znx6 undefined"><div class="css-12va8w7"><span style="font-size:0;line-height:0"></span><span style="font-size:0;line-height:0"></span><div><p class="responsive">While you read this article, your body is busy at work: Chemicals are being secreted from glands, organs, and tissues, sending messages that direct your body to react in certain ways. These chemicals, called hormones, regulate everything from growth and reproduction to digestion and mental health. </p></div><div><div data-preamp="serena-chatbot"></div></div><div><p class="responsive"><a href="https://www.healthline.com/health/progesterone-function" class="content-link css-1c2ok3c">Progesterone</a> and progestin are two hormones that you may have heard of. They have similar-sounding names, and it can be tricky to tell the difference between the two. However, the differences are important to know about. Read on to learn more about these important hormones and how they can affect our bodies. </p></div><div class="css-20w1gi"><aside class="css-0 css-0" data-testid="sticky-inline-ad" data-sticky="false"><div><div data-empty="true" class="css-1sq15os"><div class="css-1hjaa0k"><span class="css-zya54r"></span></div><div id="inline2__slot" data-adbridg-ad-class="inline2__slot" data-ad="true" class="css-1t05dkn"></div></div></div></aside></div></div><div class="css-1avyp1d"><span style="font-size:0;line-height:0"></span><div><h2><div><a class="chartbeat-section" name="similarity">Is progesterone the same thing as progestin?</a></div></h2></div><span style="font-size:0;line-height:0"></span><div><p class="responsive">In short, yes and no: Progesterone is a <a href="http://e.hormone.tulane.edu/learning/progestins.html" target="_blank" rel="noopener noreferrer" class="content-link css-1c2ok3c">naturally occurring steroid</a> hormone made in varying amounts by male, female, and intersex bodies. Progestin is a synthetic chemical that mimics the effects of progesterone on the body.</p></div><div><p>So-called “<a href="https://www.healthline.com/health/natural-progesterone" class="content-link css-1c2ok3c">natural</a>” or “bioidentical” progesterone medications also exist. This name is somewhat inaccurate, though: Progesterone medications are synthesized from a <a href="https://pubchem.ncbi.nlm.nih.gov/compound/Diosgenin" target="_blank" rel="noopener noreferrer" class="content-link css-1c2ok3c">plant chemical called diosgenin</a> — which is found in wild yam.</p></div><div><p>In addition to creating progesterone for use in birth control, diosgenin is also commonly used to synthesize other steroid hormones that are used in medications, including <a href="https://www.healthline.com/health/cortisone-shot" class="content-link css-1c2ok3c">cortisone</a>, pregnenolone, and progesterone.</p></div><span class="css-zya54r"></span></div><div class="css-1avyp1d"><span style="font-size:0;line-height:0"></span><div><h2><div><a class="chartbeat-section" name="functions">What do progesterone and progestin do in the body? </a></div></h2></div><span style="font-size:0;line-height:0"></span><div><p>Female and some intersex bodies naturally produce surges of progesterone after ovulation. This drives the second half of the<a href="https://www.healthline.com/health/hormonal-imbalance-menstrual-cycle" class="content-link css-1c2ok3c"> menstrual cycle</a>, preparing the body to potentially grow an embryo from a fertilized egg.</p></div><div><p>If an egg is fertilized, the body will release even more progesterone to <a href="https://www.healthline.com/health-news/giving-progesterone-during-pregnancy-could-prevent-miscarriage" class="content-link css-1c2ok3c">support the fetus during pregnancy</a>. During pregnancy, progesterone ensures the womb grows and prevents premature contractions (which can lead to <a href="https://www.healthline.com/health/miscarriage" class="content-link css-1c2ok3c">miscarriage</a>).</p></div><div><p class="responsive">In male and other intersex bodies, progesterone is produced in lower quantities. In these bodies progesterone plays an important role in sperm development, maintaining <a href="https://www.healthline.com/health/low-testosterone/testosterone-levels-by-age" class="content-link css-1c2ok3c">testosterone levels</a>, and other body functions.</p></div><div><p class="responsive">When a person’s progesterone levels are high, they <a href="https://medlineplus.gov/druginfo/meds/a604017.html" target="_blank" rel="noopener noreferrer" class="content-link css-1c2ok3c">may experience</a>: </p></div><div><ul><li><a href="https://www.healthline.com/health/hormones-weight-gain-pov#1" class="content-link css-1c2ok3c">weight gain</a></li><li><a href="https://www.healthline.com/health/causes-of-mood-swing" class="content-link css-1c2ok3c">moodiness</a></li><li><a href="https://www.healthline.com/health/depression/menstrual-depression" class="content-link css-1c2ok3c">depression</a></li><li><a href="https://www.healthline.com/health/birth-control/can-birth-control-make-you-tired" class="content-link css-1c2ok3c">fatigue</a></li></ul></div><div><p class="responsive">When levels are <a href="https://medlineplus.gov/druginfo/meds/a604017.html" target="_blank" rel="noopener noreferrer" class="content-link css-1c2ok3c">too low</a>, they may lead to <a href="https://www.healthline.com/health/menstrual-periods-heavy-prolonged-or-irregular" class="content-link css-1c2ok3c">irregular periods</a>, anxiety, <a href="https://www.healthline.com/health/hormonal-headaches" class="content-link css-1c2ok3c">headaches</a>, and depression. People with low progesterone levels may have difficulty getting pregnant and keeping a pregnancy. What a normal progesterone level is for a person depends on their age, sex, gender, and individual health status.</p></div></div><div class="css-1avyp1d"><span style="font-size:0;line-height:0"></span><div><h2><div><a class="chartbeat-section" name="differences">Progestin vs. progesterone vs. progestogen: What’s the difference? </a></div></h2></div><span style="font-size:0;line-height:0"></span><div><p class="responsive">Two types of progesterone medications emerged during the early development of birth control pills in the 1950s and 1960s. This includes <hl-trusted-source source="BMC/BioMed Central" rationale="Peer reviewed journal"><a href="https://contraceptionmedicine.biomedcentral.com/articles/10.1186/s40834-020-00142-5" target="_blank" rel="noopener noreferrer" class="content-link css-1c2ok3c">progestin</a></hl-trusted-source>, a type of synthetic (human-made) steroid hormone that’s still popularly used in birth control pills. </p></div><div><p class="responsive">Progestins work similarly to progesterone in the body, but each type of synthetic progestin has its own effects on the body and may be used to treat different conditions.</p></div><div><p class="responsive">In addition to its key use in <a href="https://www.healthline.com/health/birth-control-without-estrogen" class="content-link css-1c2ok3c">progestin-only birth control</a> “mini-pills” and combination estrogen-progestin birth control pills, the common uses for progestins are to treat irregular menstrual periods, including amenorrhea and abnormal bleeding. Some <a href="https://www.sciencedirect.com/topics/neuroscience/progestin" target="_blank" rel="noopener noreferrer" class="content-link css-1c2ok3c">others include</a>:</p></div><div><ul><li>treating certain cancers that react to hormones</li><li>providing <a href="https://www.healthline.com/health/what-is-gender-affirming-care" class="content-link css-1c2ok3c">gender-affirming therapy</a></li><li>alleviating <a href="https://www.healthline.com/health/menopause/symptoms-signs" class="content-link css-1c2ok3c">symptoms of menopause</a></li><li><a href="https://www.healthline.com/health/managing-osteoporosis/can-osteoporosis-be-reversed" class="content-link css-1c2ok3c">slowing bone loss</a></li><li>part of fertility treatments </li></ul></div><div><p class="responsive">Progestin medications <a href="https://www.sciencedirect.com/topics/neuroscience/progestin" target="_blank" rel="noopener noreferrer" class="content-link css-1c2ok3c">may come in</a> pill, gel, cream, injection, transdermal patch, or suppository form, depending on its use.</p></div><span class="css-zya54r"></span></div><div class="css-1avyp1d"><span style="font-size:0;line-height:0"></span><div><h2><div><a class="chartbeat-section" name="safety">Is progestin good for you? </a></div></h2></div><span style="font-size:0;line-height:0"></span><div><p class="responsive">For some people, progestin may be the best available medication to address their needs. In other cases, people may choose between progestin and progesterone medications. </p></div><div><p class="responsive">Some progesterone medications, such as topical creams, can be bought over the counter to address some of the <a href="https://www.healthline.com/health/menopause" class="content-link css-1c2ok3c">symptoms of menopause</a>. The side effects of both progestin and progesterone are similar. For both types of medications, it’s important to follow dosage directions to avoid potentially serious adverse side effects.</p></div><div><p class="responsive">Compare the <a href="https://www.sciencedirect.com/topics/neuroscience/progestin" target="_blank" rel="noopener noreferrer" class="content-link css-1c2ok3c">side effects</a> of progesterone medications and progestin medications:</p></div><div><div class="scrollTable css-1iwt4bv"><table class="responsive css-1pp4cxb"><tbody><tr><td><strong>Progestin</strong></td><td><strong>Progesterone</strong></td></tr><tr><td>increased risk of <a href="https://academic.oup.com/edrv/article/41/2/320/5568276" target="_blank" rel="noopener noreferrer" class="content-link css-1c2ok3c">breast cancer</a></td><td>increased <hl-trusted-source source="PubMed Central" rationale="Highly respected database from the National Institutes of Health"><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960754/" target="_blank" rel="noopener noreferrer" class="content-link css-1c2ok3c">risk of tumors</a></hl-trusted-source></td></tr><tr><td>changes in menstrual bleeding</td><td>depression</td></tr><tr><td>breast tenderness</td><td>breast tenderness</td></tr><tr><td>headaches</td><td>headaches</td></tr><tr><td>nausea</td><td>skin reactions</td></tr><tr><td><hl-trusted-source source="JAMA" rationale="Highly respected journal,Expert written journal,Peer reviewed journal"><a href="https://jamanetwork.com/journals/jama/article-abstract/201922" target="_blank" rel="noopener noreferrer" class="content-link css-1c2ok3c">increased risk</a></hl-trusted-source> of blood clots for newer progestins </td><td>increased risk of blood clotting</td></tr></tbody></table></div></div><div><div id="widget_call_out_be12697a-1af7-4b38-83a7-a0b1f0c3db8e" class="css-1k93l86"><span style="font-size:0;line-height:0"></span><div class="css-1r9bcg7"><div class="css-xqvouu"><h3 class="css-2nwgta">Don’t forget! </h3><div class="css-19f8tkk"><p class="standout--body">While these treatments can be lifesaving, they can also have dangerous side effects. Always follow your doctor’s dosing instructions for any hormonal treatment carefully and discuss any new symptoms with them as soon as possible.</p></div></div></div><div class="css-1uwjw6e"><div></div><div class="css-wvglsa"><svg alt="Healthline" width="75" height="12" xmlns="http://www.w3.org/2000/svg" fill="none" viewBox="0 0 113 18"><path fill="#000" d="M14.794 17.497H9.412V8.956c0-.898-.643-1.474-1.4-1.474-.734 0-1.621.599-1.621 1.474v8.541H1.558V3.891L0 2.786C1.78 2.187 4.765.898 6.39 0v7.137c.645-.806 2.222-1.842 4.225-1.842 2.537 0 3.628 1.68 3.628 3.684v7.21c0 .218.184.654.551 1.308Zm55.493 0h-5.383V8.956c0-.898-.643-1.474-1.4-1.474-.734 0-1.621.599-1.621 1.474v8.541H57.05V3.891l-1.558-1.105c1.78-.599 4.765-1.888 6.39-2.786v7.137c.645-.806 2.222-1.842 4.225-1.842 2.537 0 3.628 1.68 3.628 3.684v7.21c0 .218.184.654.551 1.308Zm-43.724-2.031v.852C25.492 17.24 24.309 18 21.764 18c-4.018 0-6.473-2.695-6.473-6.013 0-3.962 2.522-6.657 6.228-6.657 3.66 0 5.044 2.51 5.044 5.667h-6.691c.29 3.64 2.316 5.298 4.169 5.298.893 0 1.897-.3 2.522-.83ZM21.29 10.28c1.077 0 1.2-.307 1.2-1.208 0-.69-.123-2.393-1.2-2.393s-1.2 1.702-1.2 2.393c0 .9.123 1.208 1.2 1.208Zm91.21 5.181v.853c-1.071.921-2.254 1.681-4.799 1.681-4.018 0-6.473-2.695-6.473-6.012 0-3.963 2.522-6.658 6.228-6.658 3.66 0 5.044 2.511 5.044 5.667h-6.691c.29 3.64 2.316 5.299 4.169 5.299.893 0 1.897-.3 2.522-.83Zm-5.273-5.185c1.077 0 1.2-.307 1.2-1.208 0-.69-.123-2.393-1.2-2.393s-1.2 1.703-1.2 2.393c0 .901.123 1.208 1.2 1.208Zm-67.008 5.084.534.113c-.244.988-.957 2.526-3.249 2.526-1.914 0-2.451-1.175-2.852-2.419C34.32 16.733 33.008 18 30.516 18c-2.226 0-3.45-.99-3.45-2.857 0-2.073 2.023-3.593 7.075-5.09v-2.19c0-1.128-.601-1.52-1.27-1.52-.6 0-1.554.645-1.554 1.659 0 .484.089.852.156 1.336 0 .622-.712 1.567-1.803 1.567-1.202 0-1.78-.876-1.78-1.89 0-1.658 1.535-3.685 5.563-3.685 4.184 0 5.52 2.211 5.52 4.33v5.622c0 .345.133.69.512.69.334 0 .56-.189.734-.611Zm-6.052-.425v-4.174c-1.693.688-2.279 2.385-2.279 3.692 0 1.055.326 1.537 1.107 1.537.684 0 1.172-.436 1.172-1.055Zm12.971 2.561H41.58V3.891L40.1 2.786C41.791 2.187 44.901.898 46.445 0v16.19c0 .207.231.642.693 1.307Zm30.457 0h-5.558V3.891l-1.481-1.105C72.248 2.187 75.358.898 76.903 0v16.19c0 .207.23.642.692 1.307Zm-22.122-1.41v.853c-.81.691-2.153 1.06-3.602 1.06-2.387 0-3.218-1.774-3.218-3.272V6.72H47.5l6.053-5.313v4.378h1.919v.935h-1.919v8.675c0 .691.405 1.014.896 1.014.298 0 .83-.138 1.023-.323Zm26.74-10.946c-1.375 0-2.471-1.14-2.471-2.57C79.742 1.14 80.838 0 82.213 0c1.376 0 2.472 1.14 2.472 2.57 0 1.431-1.096 2.571-2.472 2.571Zm3.254 12.356h-5.674V8.93l-1.561-1.108c1.784-.6 4.776-1.894 6.405-2.794V16.19c0 .215.276.65.83 1.307Zm15.398 0h-5.558V8.93c0-.9-.643-1.477-1.4-1.477-.734 0-1.621.6-1.621 1.477v8.567h-4.832V8.93l-1.558-1.108c1.78-.6 4.638-1.894 6.263-2.794v2.355c.801-1.062 2.35-2.124 4.352-2.124 2.537 0 3.628 1.685 3.628 3.694v7.237c0 .21.242.647.726 1.307Z"></path></svg></div></div></div></div></div><div class="css-1avyp1d"><span style="font-size:0;line-height:0"></span><div><h2><div><a class="chartbeat-section" name="treatments">Synthetic progesterone is used in a variety of medical treatments</a></div></h2></div><span style="font-size:0;line-height:0"></span><div><p class="responsive">The majority of progesterone-like medications on the market today are made of progestin. However, a growing number of progestin medications are on the market, including a few that have been approved by the FDA.</p></div><div><h3 class="responsive">Progestin vs. progesterone: uses in birth control </h3></div><div><p class="responsive">Progestin is more commonly used than progesterone in <a href="https://www.acog.org/womens-health/faqs/progestin-only-hormonal-birth-control-pill-and-injection" target="_blank" rel="noopener noreferrer" class="content-link css-1c2ok3c">various forms of birth control</a>, including the hormonal IUD, pill, and injection. </p></div><div><p class="responsive">In these uses, progestin thickens the mucus of the cervix so that sperm can’t enter to fertilize an egg. It also thickens the lining of the uterus, controlling bleeding, and can sometimes stop ovulation.</p></div><div><p class="responsive">Some progestins are mixed with estrogens to produce combined birth control pills that prevent pregnancy by preventing ovulation. These pills carry a risk of blood clots for people over age 35, especially if they smoke.</p></div><div><h3 class="responsive">Progestin vs. progesterone: uses in menstrual cycle treatment</h3></div><div><p class="responsive">One <hl-trusted-source source="BMC/BioMed Central" rationale="Peer reviewed journal"><a href="https://contraceptionmedicine.biomedcentral.com/articles/10.1186/s40834-020-00142-5" target="_blank" rel="noopener noreferrer" class="content-link css-1c2ok3c">recent study</a></hl-trusted-source> notes that women are increasingly looking for progestin-based pills, injections, and IUDs to control or stop menstrual bleeding.</p></div><div><p class="responsive">Progestin is also used to treat <a href="https://www.healthline.com/health/polycystic-ovary-disease" class="content-link css-1c2ok3c">polycystic ovarian syndrome</a> (PCOS). However, due to the wide availability of bioidentical progesterones on the market, many people use over-the-counter progesterone creams to help regulate irregular periods.</p></div><div><h3 class="responsive">Progestin vs. progesterone: uses in fertility treatment</h3></div><div><p class="responsive">Bioidentical progesterones are now popularly used in fertility treatments. Many products are now on the market, from creams to pills. However, little research exists on the efficacy of many of these treatments.</p></div><div><h3 class="responsive">Progestin vs. progesterone: uses in menopause symptom treatment </h3></div><div><p class="responsive">In treating menopause symptoms, including <a href="https://www.tandfonline.com/doi/full/10.1080/13697137.2018.1467400" target="_blank" rel="noopener noreferrer" class="content-link css-1c2ok3c">bone loss</a>, progestin is a commonly prescribed medication. However, over-the-counter progesterone creams and supplements are growing in popularity. </p></div><div><p class="responsive"><a href="https://www.tandfonline.com/doi/abs/10.1080/13697137.2018.1476483" target="_blank" rel="noopener noreferrer" class="content-link css-1c2ok3c">Research suggests</a> several risks of taking progestins for menopause symptoms, including the risk of serious adverse side effects — such as <a href="https://www.healthline.com/health/symptoms-and-complications-blood-clots" class="content-link css-1c2ok3c">blood clots</a> and heart problems — in some older people.</p></div><div><h3 class="responsive">Progestin vs. progesterone: uses in gender-affirming care</h3></div><div><p class="responsive">While it has been overlooked in the past, experts now believe progesterone can play an important role in gender-affirming therapy when combined with estrogen for people looking to increase their body’s feminization.</p></div><div><p class="responsive"><hl-trusted-source source="PubMed Central" rationale="Highly respected database from the National Institutes of Health"><a href="https://pubmed.ncbi.nlm.nih.gov/30608551/" target="_blank" rel="noopener noreferrer" class="content-link css-1c2ok3c">Evidence shows</a></hl-trusted-source> that adding progesterone medication to a person’s <a href="https://www.healthline.com/health/what-is-gender-affirming-care" class="content-link css-1c2ok3c">gender-affirming care</a> can lead to the development of feminine secondary sex characteristics faster than estrogen alone, as well as: </p></div><div><ul><li>diminish testosterone production</li><li>increase bone mass</li><li><a href="https://www.healthline.com/health/best-time-to-sleep" class="content-link css-1c2ok3c">improve sleep</a></li><li>benefit their heart health</li></ul></div><div><div id="widget_call_out_95e328c3-8cd5-4d60-9f8f-c0745879ec25" class="css-1k93l86"><span style="font-size:0;line-height:0"></span><div class="css-1r9bcg7"><div class="css-xqvouu"><h3 class="css-2nwgta">Is progestin cream as effective as progesterone cream?</h3><div class="css-19f8tkk"><p class="standout--body">Progesterone cream is typically not made of progestin. </p><p class="standout--body">Instead, creams <a href="https://medlineplus.gov/druginfo/meds/a604017.html" target="_blank" rel="noopener noreferrer" class="content-link css-1c2ok3c">commonly contain</a> bioidentical progesterone to increase fertility, regulate the menstrual cycle, and alleviate symptoms of menopause. Some prescription progesterone gels also exist to treat infertility.</p></div></div></div><div class="css-1uwjw6e"><div></div><div class="css-wvglsa"><svg alt="Healthline" width="75" height="12" xmlns="http://www.w3.org/2000/svg" fill="none" viewBox="0 0 113 18"><path fill="#000" d="M14.794 17.497H9.412V8.956c0-.898-.643-1.474-1.4-1.474-.734 0-1.621.599-1.621 1.474v8.541H1.558V3.891L0 2.786C1.78 2.187 4.765.898 6.39 0v7.137c.645-.806 2.222-1.842 4.225-1.842 2.537 0 3.628 1.68 3.628 3.684v7.21c0 .218.184.654.551 1.308Zm55.493 0h-5.383V8.956c0-.898-.643-1.474-1.4-1.474-.734 0-1.621.599-1.621 1.474v8.541H57.05V3.891l-1.558-1.105c1.78-.599 4.765-1.888 6.39-2.786v7.137c.645-.806 2.222-1.842 4.225-1.842 2.537 0 3.628 1.68 3.628 3.684v7.21c0 .218.184.654.551 1.308Zm-43.724-2.031v.852C25.492 17.24 24.309 18 21.764 18c-4.018 0-6.473-2.695-6.473-6.013 0-3.962 2.522-6.657 6.228-6.657 3.66 0 5.044 2.51 5.044 5.667h-6.691c.29 3.64 2.316 5.298 4.169 5.298.893 0 1.897-.3 2.522-.83ZM21.29 10.28c1.077 0 1.2-.307 1.2-1.208 0-.69-.123-2.393-1.2-2.393s-1.2 1.702-1.2 2.393c0 .9.123 1.208 1.2 1.208Zm91.21 5.181v.853c-1.071.921-2.254 1.681-4.799 1.681-4.018 0-6.473-2.695-6.473-6.012 0-3.963 2.522-6.658 6.228-6.658 3.66 0 5.044 2.511 5.044 5.667h-6.691c.29 3.64 2.316 5.299 4.169 5.299.893 0 1.897-.3 2.522-.83Zm-5.273-5.185c1.077 0 1.2-.307 1.2-1.208 0-.69-.123-2.393-1.2-2.393s-1.2 1.703-1.2 2.393c0 .901.123 1.208 1.2 1.208Zm-67.008 5.084.534.113c-.244.988-.957 2.526-3.249 2.526-1.914 0-2.451-1.175-2.852-2.419C34.32 16.733 33.008 18 30.516 18c-2.226 0-3.45-.99-3.45-2.857 0-2.073 2.023-3.593 7.075-5.09v-2.19c0-1.128-.601-1.52-1.27-1.52-.6 0-1.554.645-1.554 1.659 0 .484.089.852.156 1.336 0 .622-.712 1.567-1.803 1.567-1.202 0-1.78-.876-1.78-1.89 0-1.658 1.535-3.685 5.563-3.685 4.184 0 5.52 2.211 5.52 4.33v5.622c0 .345.133.69.512.69.334 0 .56-.189.734-.611Zm-6.052-.425v-4.174c-1.693.688-2.279 2.385-2.279 3.692 0 1.055.326 1.537 1.107 1.537.684 0 1.172-.436 1.172-1.055Zm12.971 2.561H41.58V3.891L40.1 2.786C41.791 2.187 44.901.898 46.445 0v16.19c0 .207.231.642.693 1.307Zm30.457 0h-5.558V3.891l-1.481-1.105C72.248 2.187 75.358.898 76.903 0v16.19c0 .207.23.642.692 1.307Zm-22.122-1.41v.853c-.81.691-2.153 1.06-3.602 1.06-2.387 0-3.218-1.774-3.218-3.272V6.72H47.5l6.053-5.313v4.378h1.919v.935h-1.919v8.675c0 .691.405 1.014.896 1.014.298 0 .83-.138 1.023-.323Zm26.74-10.946c-1.375 0-2.471-1.14-2.471-2.57C79.742 1.14 80.838 0 82.213 0c1.376 0 2.472 1.14 2.472 2.57 0 1.431-1.096 2.571-2.472 2.571Zm3.254 12.356h-5.674V8.93l-1.561-1.108c1.784-.6 4.776-1.894 6.405-2.794V16.19c0 .215.276.65.83 1.307Zm15.398 0h-5.558V8.93c0-.9-.643-1.477-1.4-1.477-.734 0-1.621.6-1.621 1.477v8.567h-4.832V8.93l-1.558-1.108c1.78-.6 4.638-1.894 6.263-2.794v2.355c.801-1.062 2.35-2.124 4.352-2.124 2.537 0 3.628 1.685 3.628 3.694v7.237c0 .21.242.647.726 1.307Z"></path></svg></div></div></div></div><div class="css-20w1gi"><aside class="css-0 css-0" data-testid="sticky-inline-ad" data-sticky="false"><div><div data-empty="true" class="css-1sq15os"><div class="css-1hjaa0k"><span class="css-zya54r"></span></div><div id="inline13__slot" data-adbridg-ad-class="inline13__slot" data-ad="true" class="css-1t05dkn"></div></div></div></aside></div></div><div class="css-1avyp1d"><span style="font-size:0;line-height:0"></span><div><h2><div><a class="chartbeat-section" name="takeaway">Takeaway</a></div></h2></div><span style="font-size:0;line-height:0"></span><div><p class="responsive">Progestin and progesterone are two kinds of steroid medications used in care for menstrual issues, menopause symptoms, fertility issues, and gender-affirming therapies. </p></div><div><p class="responsive">While they have similar names, progestin refers to a synthesized chemical that acts similarly to natural progesterone in the body. Progesterone medications aren’t made from human chemicals but from plants. They also act similarly to progesterone in the body.</p></div><div><p class="responsive">The kind of progesterone medication you might use depends on your needs and medical history. Talk with your doctor to <a href="https://www.healthline.com/health/progesterone-for-menopause" class="content-link css-1c2ok3c">learn more about your options</a>.</p></div></div></article><span class="css-zya54r"></span></div><div><div class="css-8q0s1n css-10dx3t"><div class="css-15lc7zf"><h3 id="bylineArticleTools">How we reviewed this article:</h3><div class="css-vrhe66"><button type="button" class="css-5sudr5"><div class="css-rre5oz"><span class="css-1d75hb8"><svg xmlns="http://www.w3.org/2000/svg" width="20" height="20" fill="none" viewBox="0 0 20 20"><path fill="currentColor" fill-rule="evenodd" d="M0 10C0 4.477 4.477 0 10 0s10 4.477 10 10-4.477 10-10 10S0 15.523 0 10Zm18.5 0a8.5 8.5 0 1 0-17 0 8.5 8.5 0 0 0 17 0ZM10 4c-.823 0-1.5.677-1.5 1.518C8.5 6.323 9.177 7 10 7c.841 0 1.5-.677 1.5-1.482A1.5 1.5 0 0 0 10 4Zm0 4.5a1 1 0 0 1 1 1V15a1 1 0 1 1-2 0V9.5a1 1 0 0 1 1-1Z" clip-rule="evenodd"></path></svg></span><span>Sources</span></div></button><button type="button" open="" class="css-5sudr5"><div class="css-rre5oz"><span class="css-1d75hb8"><svg xmlns="http://www.w3.org/2000/svg" width="22" height="20" fill="none" viewBox="0 0 22 20"><path fill="currentColor" d="M3.181 9.732c.43 0 .793-.003 1.157 0 .66.007 1.023.613.696 1.19a221.037 221.037 0 0 1-1.774 3.072c-.329.557-1.038.553-1.366-.007-.6-1.02-1.191-2.043-1.774-3.072-.325-.575.043-1.177.708-1.183h.808c.055-.447.088-.882.165-1.309.557-3.104 2.187-5.489 4.913-7.056 3.679-2.114 8.05-1.75 11.352.913 2.062 1.664 3.29 3.84 3.625 6.473.678 5.323-3.012 10.254-8.308 11.103-3.215.515-6.044-.356-8.476-2.515-.297-.259-.373-.598-.233-.92.14-.323.454-.52.805-.454.187.04.361.13.504.26a8.618 8.618 0 0 0 4.383 2.108c3.72.63 7.513-1.394 9.084-4.846a8.521 8.521 0 0 0-6.047-11.911C8.763.618 4.201 3.71 3.353 8.4c-.078.427-.112.863-.172 1.331Z"></path><path fill="currentColor" d="M10.12 7.212V3.711a.778.778 0 0 1 1.535-.171c.017.104.024.21.02.314v6.25a.412.412 0 0 0 .168.368c1.125.89 2.241 1.791 3.362 2.686.26.208.405.466.342.803-.11.583-.76.829-1.244.459-.485-.37-.952-.756-1.427-1.135-.79-.633-1.578-1.27-2.373-1.898a.933.933 0 0 1-.385-.793c.008-1.125.003-2.252.003-3.382Z"></path></svg></span><span>History</span></div></button></div><div class="css-1ndif92"><div class="css-1ubyuqj"><div id="article-resources" role="region" class="css-1ugaz02"><div class="css-0">Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical journals and associations. We only use quality, credible sources to ensure content accuracy and integrity. You can learn more about how we ensure our content is accurate and current by reading our <a class="css-1c2ok3c" href="https://www.healthline.com/about/process">editorial policy</a>.</div><ul class="css-1vedeqe"><li class="css-1ti7iub"><cite><span>Asi N, et al. (2016). Progesterone vs. synthetic progestins and the risk of breast cancer: A systematic review and meta-analysis.</span><br/><a class="css-1c2ok3c css-1ivue52" target="_blank" rel="noopener noreferrer" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960754/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960754/</a></cite></li><li class="css-1ti7iub"><cite><span>Diosgenin. (n.d.)</span><br/><a class="css-1c2ok3c css-1ivue52" target="_blank" rel="noopener noreferrer" href="https://pubchem.ncbi.nlm.nih.gov/compound/Diosgenin">https://pubchem.ncbi.nlm.nih.gov/compound/Diosgenin</a></cite></li><li class="css-1ti7iub"><cite><span>Gompel A, et al. (2018). Progesterone, progestins and the breast in menopause treatment.</span><br/><a class="css-1c2ok3c css-1ivue52" target="_blank" rel="noopener noreferrer" href="https://www.tandfonline.com/doi/abs/10.1080/13697137.2018.1476483">https://www.tandfonline.com/doi/abs/10.1080/13697137.2018.1476483</a></cite></li><li class="css-1ti7iub"><cite><span>Melmed S, et al. (2020). Physiology and pathology of the female reproductive Axis.</span><br/><a class="css-1c2ok3c css-1ivue52" target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/topics/neuroscience/progestin">https://www.sciencedirect.com/topics/neuroscience/progestin</a></cite></li><li class="css-1ti7iub"><cite><span>Progesterone. (2016).</span><br/><a class="css-1c2ok3c css-1ivue52" target="_blank" rel="noopener noreferrer" href="https://medlineplus.gov/druginfo/meds/a604017.html">https://medlineplus.gov/druginfo/meds/a604017.html</a></cite></li><li class="css-1ti7iub"><cite><span>Progesterone. (n.d.).</span><br/><a class="css-1c2ok3c css-1ivue52" target="_blank" rel="noopener noreferrer" href="https://pubchem.ncbi.nlm.nih.gov/compound/Progesterone">https://pubchem.ncbi.nlm.nih.gov/compound/Progesterone</a></cite></li><li class="css-1ti7iub"><cite><span>Prior JC. (2018). Progesterone for the prevention and treatment of osteoporosis in women.</span><br/><a class="css-1c2ok3c css-1ivue52" target="_blank" rel="noopener noreferrer" href="https://www.tandfonline.com/doi/full/10.1080/13697137.2018.1467400">https://www.tandfonline.com/doi/full/10.1080/13697137.2018.1467400</a></cite></li><li class="css-1ti7iub"><cite><span>Prior JC. (2019). Progesterone is important for transgender women's therapy-applying evidence for the benefits of progesterone in ciswomen.</span><br/><a class="css-1c2ok3c css-1ivue52" target="_blank" rel="noopener noreferrer" href="https://pubmed.ncbi.nlm.nih.gov/30608551/">https://pubmed.ncbi.nlm.nih.gov/30608551/</a></cite></li><li class="css-1ti7iub"><cite><span>Progestin-only hormonal birth control: Pill and injection. (2020).</span><br/><a class="css-1c2ok3c css-1ivue52" target="_blank" rel="noopener noreferrer" href="https://www.acog.org/womens-health/faqs/progestin-only-hormonal-birth-control-pill-and-injection">https://www.acog.org/womens-health/faqs/progestin-only-hormonal-birth-control-pill-and-injection</a></cite></li><li class="css-1ti7iub"><cite><span>Reis FM, et al. (2020). Progesterone receptor ligands for the treatment of endometriosis: the mechanisms behind therapeutic success and failure.</span><br/><a class="css-1c2ok3c css-1ivue52" target="_blank" rel="noopener noreferrer" href="https://academic.oup.com/humupd/article/26/4/565/5837503?login=true">https://academic.oup.com/humupd/article/26/4/565/5837503?login=true</a></cite></li><li class="css-1ti7iub"><cite><span>Shoupe D. (2021). The Progestin revolution: Progestins are arising as the dominant players in the tight interlink between contraceptives and bleeding control.</span><br/><a class="css-1c2ok3c css-1ivue52" target="_blank" rel="noopener noreferrer" href="https://contraceptionmedicine.biomedcentral.com/articles/10.1186/s40834-020-00142-5">https://contraceptionmedicine.biomedcentral.com/articles/10.1186/s40834-020-00142-5</a></cite></li><li class="css-1ti7iub"><cite><span>The hormones: Progestins. (n.d.).</span><br/><a class="css-1c2ok3c css-1ivue52" target="_blank" rel="noopener noreferrer" href="http://e.hormone.tulane.edu/learning/progestins.html">http://e.hormone.tulane.edu/learning/progestins.html</a></cite></li><li class="css-1ti7iub"><cite><span>Trabert B, et al. (2019). Progesterone and breast cancer.</span><br/><a class="css-1c2ok3c css-1ivue52" target="_blank" rel="noopener noreferrer" href="https://academic.oup.com/edrv/article/41/2/320/5568276">https://academic.oup.com/edrv/article/41/2/320/5568276</a></cite></li><li class="css-1ti7iub"><cite><span>Voelker R. (2011). Risk of blood clots higher for oral contraceptives with certain progestins.</span><br/><a class="css-1c2ok3c css-1ivue52" target="_blank" rel="noopener noreferrer" href="https://jamanetwork.com/journals/jama/article-abstract/201922">https://jamanetwork.com/journals/jama/article-abstract/201922</a></cite></li></ul></div></div></div><div open="" class="css-1ndif92"></div></div><div class="css-k1nhka" data-testid="share-tools"><p>Share this article</p><div class="css-14uyzrw"><div class="button-wrapper print"><a class="css-j5n0jw print button icon icon-hl-print" target="_blank" title="Print this page"></a></div><div class="button-wrapper email"><a class="css-j5n0jw email button icon icon-hl-email" target="_blank" title="Email this page"></a></div><div class="button-wrapper facebook"><a class="css-j5n0jw facebook button icon icon-hl-facebook" href="https://www.facebook.com/sharer/sharer.php?u=https%3A%2F%2Fwww.healthline.com%2Fhealth%2Fwomens-health%2Fprogestin-vs-progesterone%3Futm_medium%3Dsocial%26utm_source%3Dfacebook%26utm_campaign%3Dsocial-sharebar-referred-desktop" rel="noopener noreferrer nofollow" target="_blank" title="Share on Facebook"></a></div><div class="button-wrapper twitter"><a class="css-j5n0jw twitter button icon icon-hl-twitter" href="https://twitter.com/intent/tweet?via=healthline&text=Progestin%20vs%20Progesterone%3A%20Are%20They%20the%20Same%20Thing%3F%20&url=https%3A%2F%2Fwww.healthline.com%2Fhealth%2Fwomens-health%2Fprogestin-vs-progesterone%3Futm_medium%3Dsocial%26utm_source%3Dtwitter%26utm_campaign%3Dsocial-sharebar-referred-desktop" rel="noopener noreferrer nofollow" target="_blank" title="Share on Twitter"></a></div><div class="button-wrapper more"><a class="css-j5n0jw more button icon icon-hl-more" target="_blank" title="Show more"></a></div></div></div></div></div><span class="css-zya54r"></span></div><section style="position:relative;margin-top:0" class="css-82r5pg"><div class="css-dorrmn"><div class="css-npv6dx"><div data-testid="byline"><section data-testid="byline" class="css-lizeih"><div class="css-1q67gt9"><div class="css-quwpxp"><img src="//i0.wp.com/post.healthline.com/wp-content/uploads/2022/01/Stacy-Henigsman-500x500-Bio.png?w=105&h=105" alt=""/></div></div><div><span><span><a class="css-1c2ok3c css-ro87dg" target="_blank" rel="noopener noreferrer">Medically reviewed</a> by <a class="css-1c2ok3c css-ro87dg" target="_blank" rel="noopener noreferrer">Stacy A. Henigsman, DO</a></span></span> — <span><span><span><span>Written by <a class="css-1c2ok3c css-ro87dg" target="_blank" rel="noopener noreferrer">Erica Cirino</a></span></span></span></span> <span> on July 18, 2022</span></div></section></div></div></div><span class="css-zya54r"></span><div data-empty="true" class="css-1d8h8gm"><div class="css-1hjaa0k"><span class="css-zya54r"></span></div><div id="DMR1__slot" data-adbridg-ad-class="DMR1" data-ad="true" class="css-488q2e"></div></div><div class="css-h9jo37" data-dynamic-ads="true"><object type="text/html" data="about:blank" aria-label="advertisement" class="css-7vynax"></object></div></section></div></div></div><aside></aside><span style="font-size:0;line-height:0"></span><div><div id="read-next" class=" css-10ib5jr"><div class="css-m260rd"><div class="css-1h1rean"><div class="css-z468a2"><h3 class="css-1g3kp27">Read this next</h3></div><section class="css-82r5pg"></section></div></div><ul class="css-1l95nvm"><li class="css-12weawj"><div class="css-m260rd"><div class="css-1h1rean"><div class="css-1r7frvz"><div class="css-lm0pdr"><span style="font-size:0;line-height:0"></span><figure class="css-1e4ja14 css-f0t0lw"><a class="css-j5n0jw" data-event="engagement|bottom page content promo click|/health/progesterone-function;engagement|bottom page content promo click index|1" data-element-event="INTERNAL LINK|FOOTER|Any Page|Read This Next|LINK|Everything You Need to Know About Progesterone|rn0" href="https://www.healthline.com/health/progesterone-function?utm_source=ReadNext" aria-label="image-link" data-ga4="Read Next button clicks" data-testid="image-link" aria-hidden="true" tabindex="-1"><div class="css-79elbk"><span class="css-rwmw5v css-1pf0x3y"><span class="css-1767n2d"><lazy-image alt="Everything You Need to Know About Progesterone" src="https://media.post.rvohealth.io/wp-content/uploads/2019/01/Crochet-flowers-on-girls-stomach-732x549-thumbnail.jpg" srcSet="https://media.post.rvohealth.io/wp-content/uploads/2019/01/Crochet-flowers-on-girls-stomach-732x549-thumbnail.jpg 200w" className="css-1lyqwde"></lazy-image></span></span><span class="css-1fb1nmp"><span class="css-a10gts"></span></span></div></a></figure><div class="css-u8uhak"><a class="css-sqa1yu" data-event="engagement|bottom page content promo click|/health/progesterone-function;engagement|bottom page content promo click index|1" data-element-event="INTERNAL LINK|FOOTER|Any Page|Read This Next|LINK|Everything You Need to Know About Progesterone|rn0" href="https://www.healthline.com/health/progesterone-function?utm_source=ReadNext" data-testid="title-link" data-ga4="Read Next button clicks">Everything You Need to Know About Progesterone</a><p class=""><a class="css-onvglr" data-event="engagement|bottom page content promo click|/health/progesterone-function;engagement|bottom page content promo click index|1" data-element-event="INTERNAL LINK|FOOTER|Any Page|Read This Next|LINK|Everything You Need to Know About Progesterone|rn0" href="https://www.healthline.com/health/progesterone-function?utm_source=ReadNext" data-testid="text-link" data-ga4="Read Next button clicks" aria-hidden="true" tabindex="-1">Progesterone is an important hormone for both females and males. Learn about its specific functions, how its levels are tested, and what test results…</a></p><a class="css-v5yzal css-ysgmro" data-event="engagement|bottom page content promo click|/health/progesterone-function;engagement|bottom page content promo click index|1" data-element-event="INTERNAL LINK|FOOTER|Any Page|Read This Next|LINK|Everything You Need to Know About Progesterone|rn0" href="https://www.healthline.com/health/progesterone-function?utm_source=ReadNext" data-ga4="Read Next button clicks">READ MORE<span class="icon-hl-arrow-right selector css-2kgwd5"></span></a></div></div></div><section class="css-82r5pg css-1ub4i5m"><div data-empty="true" class="css-vhteyv"><div class="css-1hjaa0k"><span class="css-zya54r"></span></div><div id="DCMR1__slot" data-adbridg-ad-class="DCMR1" data-ad="true" class="css-prb4v6"></div></div></section></div></div></li><li class="css-12weawj"><div class="css-m260rd"><div class="css-1h1rean"><div class="css-1r7frvz"><span class="css-zya54r"></span></div><section class="css-82r5pg css-1ub4i5m"><div data-empty="true" class="css-vhteyv"><div class="css-1hjaa0k"><span class="css-zya54r"></span></div><div id="DCMR1__slot" data-adbridg-ad-class="DCMR1" data-ad="true" class="css-prb4v6"></div></div></section></div></div></li><li class="css-12weawj"><div class="css-m260rd"><div class="css-1h1rean"><div class="css-1r7frvz"><div class="css-lm0pdr"><span style="font-size:0;line-height:0"></span><figure class="css-1e4ja14 css-f0t0lw"><a class="css-j5n0jw" data-event="engagement|bottom page content promo click|/health/birth-control-without-estrogen;engagement|bottom page content promo click index|2" data-element-event="INTERNAL LINK|FOOTER|Any Page|Read This Next|LINK|The Minipill and Other Estrogen-Free Birth Control Options|rn1" href="https://www.healthline.com/health/birth-control-without-estrogen?utm_source=ReadNext" aria-label="image-link" data-ga4="Read Next button clicks" data-testid="image-link" aria-hidden="true" tabindex="-1"><div class="css-79elbk"><span class="css-rwmw5v css-1pf0x3y"><span class="css-1767n2d"><lazy-image alt="The Minipill and Other Estrogen-Free Birth Control Options" src="https://media.post.rvohealth.io/wp-content/uploads/2020/05/birth-control-pills-732x549-thumbnail-732x549.jpg" srcSet="https://media.post.rvohealth.io/wp-content/uploads/2020/05/birth-control-pills-732x549-thumbnail-732x549.jpg 200w" className="css-1lyqwde"></lazy-image></span></span><span class="css-1fb1nmp"><span class="css-a10gts"></span></span></div></a></figure><div class="css-u8uhak"><a class="css-sqa1yu" data-event="engagement|bottom page content promo click|/health/birth-control-without-estrogen;engagement|bottom page content promo click index|2" data-element-event="INTERNAL LINK|FOOTER|Any Page|Read This Next|LINK|The Minipill and Other Estrogen-Free Birth Control Options|rn1" href="https://www.healthline.com/health/birth-control-without-estrogen?utm_source=ReadNext" data-testid="title-link" data-ga4="Read Next button clicks">The Minipill and Other Estrogen-Free Birth Control Options</a><section data-testid="byline" class="css-8he51f"><div class="css-1pz7193"><div class="css-quwpxp"><lazy-image alt="" src="https://media.post.rvohealth.io/wp-content/uploads/2022/01/Carolyn-Kay-New-Headshot-500x500-Bio.png"></lazy-image></div></div><div><span><span>Medically reviewed by <a class="css-1c2ok3c css-ro87dg" href="https://www.healthline.com/medical-team">Carolyn Kay, M.D.</a></span></span></div></section><p class=""><a class="css-onvglr" data-event="engagement|bottom page content promo click|/health/birth-control-without-estrogen;engagement|bottom page content promo click index|2" data-element-event="INTERNAL LINK|FOOTER|Any Page|Read This Next|LINK|The Minipill and Other Estrogen-Free Birth Control Options|rn1" href="https://www.healthline.com/health/birth-control-without-estrogen?utm_source=ReadNext" data-testid="text-link" data-ga4="Read Next button clicks" aria-hidden="true" tabindex="-1">If you’re looking for estrogen-free birth control, the mini pill is one option. A progestin shot, implant, or progestin IUD are other hormonal…</a></p><a class="css-v5yzal css-ysgmro" data-event="engagement|bottom page content promo click|/health/birth-control-without-estrogen;engagement|bottom page content promo click index|2" data-element-event="INTERNAL LINK|FOOTER|Any Page|Read This Next|LINK|The Minipill and Other Estrogen-Free Birth Control Options|rn1" href="https://www.healthline.com/health/birth-control-without-estrogen?utm_source=ReadNext" data-ga4="Read Next button clicks">READ MORE<span class="icon-hl-arrow-right selector css-2kgwd5"></span></a></div></div></div><section class="css-82r5pg css-1ub4i5m"></section></div></div></li><li class="css-12weawj"><div class="css-m260rd"><div class="css-1h1rean"><div class="css-1r7frvz"><div class="css-lm0pdr"><span style="font-size:0;line-height:0"></span><figure class="css-1e4ja14 css-f0t0lw"><a class="css-j5n0jw" data-event="engagement|bottom page content promo click|/health/natural-progesterone;engagement|bottom page content promo click index|3" data-element-event="INTERNAL LINK|FOOTER|Any Page|Read This Next|LINK|How to Naturally Increase Your Progesterone Levels|rn2" href="https://www.healthline.com/health/natural-progesterone?utm_source=ReadNext" aria-label="image-link" data-ga4="Read Next button clicks" data-testid="image-link" aria-hidden="true" tabindex="-1"><div class="css-79elbk"><span class="css-rwmw5v css-1pf0x3y"><span class="css-1767n2d"><lazy-image alt="How to Naturally Increase Your Progesterone Levels" src="https://media.post.rvohealth.io/wp-content/uploads/2020/09/732x549_THUMB_Natural_Progesterone-1-732x549.jpg" srcSet="https://media.post.rvohealth.io/wp-content/uploads/2020/09/732x549_THUMB_Natural_Progesterone-1-732x549.jpg 200w" className="css-1lyqwde"></lazy-image></span></span><span class="css-1fb1nmp"><span class="css-a10gts"></span></span></div></a></figure><div class="css-u8uhak"><a class="css-sqa1yu" data-event="engagement|bottom page content promo click|/health/natural-progesterone;engagement|bottom page content promo click index|3" data-element-event="INTERNAL LINK|FOOTER|Any Page|Read This Next|LINK|How to Naturally Increase Your Progesterone Levels|rn2" href="https://www.healthline.com/health/natural-progesterone?utm_source=ReadNext" data-testid="title-link" data-ga4="Read Next button clicks">How to Naturally Increase Your Progesterone Levels</a><section data-testid="byline" class="css-8he51f"><div class="css-1pz7193"><div class="css-quwpxp"><lazy-image alt="" src="https://media.post.rvohealth.io/wp-content/uploads/2022/01/Debra-Rose-500x500-Bio.png"></lazy-image></div></div><div><span><span>Medically reviewed by <a class="css-1c2ok3c css-ro87dg" href="https://www.healthline.com/medical-team">Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT</a></span></span></div></section><p class=""><a class="css-onvglr" data-event="engagement|bottom page content promo click|/health/natural-progesterone;engagement|bottom page content promo click index|3" data-element-event="INTERNAL LINK|FOOTER|Any Page|Read This Next|LINK|How to Naturally Increase Your Progesterone Levels|rn2" href="https://www.healthline.com/health/natural-progesterone?utm_source=ReadNext" data-testid="text-link" data-ga4="Read Next button clicks" aria-hidden="true" tabindex="-1">What's the best and most natural way to increase your progesterone levels? We look at the pros and cons of creams, pills, foods, and more.</a></p><a class="css-v5yzal css-ysgmro" data-event="engagement|bottom page content promo click|/health/natural-progesterone;engagement|bottom page content promo click index|3" data-element-event="INTERNAL LINK|FOOTER|Any Page|Read This Next|LINK|How to Naturally Increase Your Progesterone Levels|rn2" href="https://www.healthline.com/health/natural-progesterone?utm_source=ReadNext" data-ga4="Read Next button clicks">READ MORE<span class="icon-hl-arrow-right selector css-2kgwd5"></span></a></div></div></div><section class="css-82r5pg css-1ub4i5m"><div data-empty="true" class="css-vhteyv"><div class="css-1hjaa0k"><span class="css-zya54r"></span></div><div id="DCMR2__slot" data-adbridg-ad-class="DCMR2" data-ad="true" class="css-prb4v6"></div></div></section></div></div></li><li class="css-12weawj"><div class="css-m260rd"><div class="css-1h1rean"><div class="css-1r7frvz"><div class="css-lm0pdr"><span style="font-size:0;line-height:0"></span><figure class="css-1e4ja14 css-f0t0lw"><a class="css-j5n0jw" data-event="engagement|bottom page content promo click|/health/female-sex-hormones;engagement|bottom page content promo click index|4" data-element-event="INTERNAL LINK|FOOTER|Any Page|Read This Next|LINK|How Do Female Sex Hormones Affect Menstruation, Pregnancy, and Other Functions?|rn3" href="https://www.healthline.com/health/female-sex-hormones?utm_source=ReadNext" aria-label="image-link" data-ga4="Read Next button clicks" data-testid="image-link" aria-hidden="true" tabindex="-1"><div class="css-79elbk"><span class="css-rwmw5v css-1pf0x3y"><span class="css-1767n2d"><lazy-image alt="How Do Female Sex Hormones Affect Menstruation, Pregnancy, and Other Functions?" src="https://media.post.rvohealth.io/wp-content/uploads/2020/08/portrait_woman-732x549-thumbnail-732x549.jpg" srcSet="https://media.post.rvohealth.io/wp-content/uploads/2020/08/portrait_woman-732x549-thumbnail-732x549.jpg 200w" className="css-1lyqwde"></lazy-image></span></span><span class="css-1fb1nmp"><span class="css-a10gts"></span></span></div></a></figure><div class="css-u8uhak"><a class="css-sqa1yu" data-event="engagement|bottom page content promo click|/health/female-sex-hormones;engagement|bottom page content promo click index|4" data-element-event="INTERNAL LINK|FOOTER|Any Page|Read This Next|LINK|How Do Female Sex Hormones Affect Menstruation, Pregnancy, and Other Functions?|rn3" href="https://www.healthline.com/health/female-sex-hormones?utm_source=ReadNext" data-testid="title-link" data-ga4="Read Next button clicks">How Do Female Sex Hormones Affect Menstruation, Pregnancy, and Other Functions?</a><section data-testid="byline" class="css-8he51f"><div class="css-1pz7193"><div class="css-quwpxp"><lazy-image alt="" src="https://media.post.rvohealth.io/wp-content/uploads/2022/01/Valinda-Riggins-Nwadike-500x500-Bio.png"></lazy-image></div></div><div><span><span>Medically reviewed by <a class="css-1c2ok3c css-ro87dg" href="https://www.healthline.com/medical-team">Valinda Riggins Nwadike, MD, MPH</a></span></span></div></section><p class=""><a class="css-onvglr" data-event="engagement|bottom page content promo click|/health/female-sex-hormones;engagement|bottom page content promo click index|4" data-element-event="INTERNAL LINK|FOOTER|Any Page|Read This Next|LINK|How Do Female Sex Hormones Affect Menstruation, Pregnancy, and Other Functions?|rn3" href="https://www.healthline.com/health/female-sex-hormones?utm_source=ReadNext" data-testid="text-link" data-ga4="Read Next button clicks" aria-hidden="true" tabindex="-1">The two main female sex hormones are estrogen and progesterone. Although testosterone is considered a male hormone, females also produce and use a…</a></p><a class="css-v5yzal css-ysgmro" data-event="engagement|bottom page content promo click|/health/female-sex-hormones;engagement|bottom page content promo click index|4" data-element-event="INTERNAL LINK|FOOTER|Any Page|Read This Next|LINK|How Do Female Sex Hormones Affect Menstruation, Pregnancy, and Other Functions?|rn3" href="https://www.healthline.com/health/female-sex-hormones?utm_source=ReadNext" data-ga4="Read Next button clicks">READ MORE<span class="icon-hl-arrow-right selector css-2kgwd5"></span></a></div></div></div><section class="css-82r5pg css-1ub4i5m"></section></div></div></li><li class="css-12weawj"><div class="css-m260rd"><div class="css-1h1rean"><div class="css-1r7frvz"><div class="css-lm0pdr"><span style="font-size:0;line-height:0"></span><figure class="css-1e4ja14 css-f0t0lw"><a class="css-j5n0jw" data-event="engagement|bottom page content promo click|/health/how-much-is-birth-control-without-insurance;engagement|bottom page content promo click index|5" data-element-event="INTERNAL LINK|FOOTER|Any Page|Read This Next|LINK|How Much Is Birth Control Without Insurance?|rn4" href="https://www.healthline.com/health/how-much-is-birth-control-without-insurance?utm_source=ReadNext" aria-label="image-link" data-ga4="Read Next button clicks" data-testid="image-link" aria-hidden="true" tabindex="-1"><div class="css-79elbk"><span class="css-rwmw5v css-1pf0x3y"><span class="css-1767n2d"><lazy-image alt="How Much Is Birth Control Without Insurance?" src="https://media.post.rvohealth.io/wp-content/uploads/2024/09/birth-control-pills-in-a-dish-with-cash-money-732x549-thumbnail.jpg" srcSet="https://media.post.rvohealth.io/wp-content/uploads/2024/09/birth-control-pills-in-a-dish-with-cash-money-732x549-thumbnail.jpg 200w" className="css-1lyqwde"></lazy-image></span></span><span class="css-1fb1nmp"><span class="css-a10gts"></span></span></div></a></figure><div class="css-u8uhak"><a class="css-sqa1yu" data-event="engagement|bottom page content promo click|/health/how-much-is-birth-control-without-insurance;engagement|bottom page content promo click index|5" data-element-event="INTERNAL LINK|FOOTER|Any Page|Read This Next|LINK|How Much Is Birth Control Without Insurance?|rn4" href="https://www.healthline.com/health/how-much-is-birth-control-without-insurance?utm_source=ReadNext" data-testid="title-link" data-ga4="Read Next button clicks">How Much Is Birth Control Without Insurance?</a><section data-testid="byline" class="css-8he51f"><div class="css-1pz7193"><div class="css-quwpxp"><lazy-image alt="" src="https://media.post.rvohealth.io/wp-content/uploads/2022/01/Alexandra-Perez-500x500-Bio.png"></lazy-image></div></div><div><span><span>Medically reviewed by <a class="css-1c2ok3c css-ro87dg" href="https://www.healthline.com/medical-team">Alexandra Perez, PharmD, MBA, BCGP</a></span></span></div></section><p class=""><a class="css-onvglr" data-event="engagement|bottom page content promo click|/health/how-much-is-birth-control-without-insurance;engagement|bottom page content promo click index|5" data-element-event="INTERNAL LINK|FOOTER|Any Page|Read This Next|LINK|How Much Is Birth Control Without Insurance?|rn4" href="https://www.healthline.com/health/how-much-is-birth-control-without-insurance?utm_source=ReadNext" data-testid="text-link" data-ga4="Read Next button clicks" aria-hidden="true" tabindex="-1">The cost of birth control without insurance varies from more affordable barrier options to higher upfront costs for long-term solutions like IUDs and…</a></p><a class="css-v5yzal css-ysgmro" data-event="engagement|bottom page content promo click|/health/how-much-is-birth-control-without-insurance;engagement|bottom page content promo click index|5" data-element-event="INTERNAL LINK|FOOTER|Any Page|Read This Next|LINK|How Much Is Birth Control Without Insurance?|rn4" href="https://www.healthline.com/health/how-much-is-birth-control-without-insurance?utm_source=ReadNext" data-ga4="Read Next button clicks">READ MORE<span class="icon-hl-arrow-right selector css-2kgwd5"></span></a></div></div></div><section class="css-82r5pg css-1ub4i5m"></section></div></div></li><li class="css-12weawj"><div class="css-m260rd"><div class="css-1h1rean"><div class="css-1r7frvz"><div class="css-lm0pdr"><span style="font-size:0;line-height:0"></span><figure class="css-1e4ja14 css-f0t0lw"><a class="css-j5n0jw" data-event="engagement|bottom page content promo click|/health/paxlovid-and-birth-control;engagement|bottom page content promo click index|6" data-element-event="INTERNAL LINK|FOOTER|Any Page|Read This Next|LINK|Does Paxlovid Interact with Hormonal Birth Control?|rn5" href="https://www.healthline.com/health/paxlovid-and-birth-control?utm_source=ReadNext" aria-label="image-link" data-ga4="Read Next button clicks" data-testid="image-link" aria-hidden="true" tabindex="-1"><div class="css-79elbk"><span class="css-rwmw5v css-1pf0x3y"><span class="css-1767n2d"><lazy-image alt="Does Paxlovid Interact with Hormonal Birth Control?" src="https://media.post.rvohealth.io/wp-content/uploads/2024/09/Paxlovid-tablets-pills-packaging-732x549-thumbnail.jpg" srcSet="https://media.post.rvohealth.io/wp-content/uploads/2024/09/Paxlovid-tablets-pills-packaging-732x549-thumbnail.jpg 200w" className="css-1lyqwde"></lazy-image></span></span><span class="css-1fb1nmp"><span class="css-a10gts"></span></span></div></a></figure><div class="css-u8uhak"><a class="css-sqa1yu" data-event="engagement|bottom page content promo click|/health/paxlovid-and-birth-control;engagement|bottom page content promo click index|6" data-element-event="INTERNAL LINK|FOOTER|Any Page|Read This Next|LINK|Does Paxlovid Interact with Hormonal Birth Control?|rn5" href="https://www.healthline.com/health/paxlovid-and-birth-control?utm_source=ReadNext" data-testid="title-link" data-ga4="Read Next button clicks">Does Paxlovid Interact with Hormonal Birth Control?</a><p class=""><a class="css-onvglr" data-event="engagement|bottom page content promo click|/health/paxlovid-and-birth-control;engagement|bottom page content promo click index|6" data-element-event="INTERNAL LINK|FOOTER|Any Page|Read This Next|LINK|Does Paxlovid Interact with Hormonal Birth Control?|rn5" href="https://www.healthline.com/health/paxlovid-and-birth-control?utm_source=ReadNext" data-testid="text-link" data-ga4="Read Next button clicks" aria-hidden="true" tabindex="-1">While there’s a lack of research on the effects of Paxlovid on birth control, there is a possibility it can reduce the effectiveness of combined…</a></p><a class="css-v5yzal css-ysgmro" data-event="engagement|bottom page content promo click|/health/paxlovid-and-birth-control;engagement|bottom page content promo click index|6" data-element-event="INTERNAL LINK|FOOTER|Any Page|Read This Next|LINK|Does Paxlovid Interact with Hormonal Birth Control?|rn5" href="https://www.healthline.com/health/paxlovid-and-birth-control?utm_source=ReadNext" data-ga4="Read Next button clicks">READ MORE<span class="icon-hl-arrow-right selector css-2kgwd5"></span></a></div></div></div><section class="css-82r5pg css-1ub4i5m"></section></div></div></li><li class="css-12weawj"><div class="css-m260rd"><div class="css-1h1rean"><div class="css-1r7frvz"><div class="css-lm0pdr"><span style="font-size:0;line-height:0"></span><figure class="css-1e4ja14 css-f0t0lw"><a class="css-j5n0jw" data-event="engagement|bottom page content promo click|/health/how-to-get-birth-control-refill;engagement|bottom page content promo click index|7" data-element-event="INTERNAL LINK|FOOTER|Any Page|Read This Next|LINK|How to Get a Birth Control Refill|rn6" href="https://www.healthline.com/health/how-to-get-birth-control-refill?utm_source=ReadNext" aria-label="image-link" data-ga4="Read Next button clicks" data-testid="image-link" aria-hidden="true" tabindex="-1"><div class="css-79elbk"><span class="css-rwmw5v css-1pf0x3y"><span class="css-1767n2d"><lazy-image alt="How to Get a Birth Control Refill" src="https://media.post.rvohealth.io/wp-content/uploads/2024/08/birth-control-empty-blister-pack-countertop-732x549-thumbnail.jpg" srcSet="https://media.post.rvohealth.io/wp-content/uploads/2024/08/birth-control-empty-blister-pack-countertop-732x549-thumbnail.jpg 200w" className="css-1lyqwde"></lazy-image></span></span><span class="css-1fb1nmp"><span class="css-a10gts"></span></span></div></a></figure><div class="css-u8uhak"><a class="css-sqa1yu" data-event="engagement|bottom page content promo click|/health/how-to-get-birth-control-refill;engagement|bottom page content promo click index|7" data-element-event="INTERNAL LINK|FOOTER|Any Page|Read This Next|LINK|How to Get a Birth Control Refill|rn6" href="https://www.healthline.com/health/how-to-get-birth-control-refill?utm_source=ReadNext" data-testid="title-link" data-ga4="Read Next button clicks">How to Get a Birth Control Refill</a><section data-testid="byline" class="css-8he51f"><div class="css-1pz7193"><div class="css-quwpxp"><lazy-image alt="" src="https://media.post.rvohealth.io/wp-content/uploads/2022/01/Alexandra-Perez-500x500-Bio.png"></lazy-image></div></div><div><span><span>Medically reviewed by <a class="css-1c2ok3c css-ro87dg" href="https://www.healthline.com/medical-team">Alexandra Perez, PharmD, MBA, BCGP</a></span></span></div></section><p class=""><a class="css-onvglr" data-event="engagement|bottom page content promo click|/health/how-to-get-birth-control-refill;engagement|bottom page content promo click index|7" data-element-event="INTERNAL LINK|FOOTER|Any Page|Read This Next|LINK|How to Get a Birth Control Refill|rn6" href="https://www.healthline.com/health/how-to-get-birth-control-refill?utm_source=ReadNext" data-testid="text-link" data-ga4="Read Next button clicks" aria-hidden="true" tabindex="-1">How to get a birth control refill depends on the method you use, whether you have a current or expired prescription, and what the laws are where you…</a></p><a class="css-v5yzal css-ysgmro" data-event="engagement|bottom page content promo click|/health/how-to-get-birth-control-refill;engagement|bottom page content promo click index|7" data-element-event="INTERNAL LINK|FOOTER|Any Page|Read This Next|LINK|How to Get a Birth Control Refill|rn6" href="https://www.healthline.com/health/how-to-get-birth-control-refill?utm_source=ReadNext" data-ga4="Read Next button clicks">READ MORE<span class="icon-hl-arrow-right selector css-2kgwd5"></span></a></div></div></div><section class="css-82r5pg css-1ub4i5m"></section></div></div></li><li class="css-12weawj"><div class="css-m260rd"><div class="css-1h1rean"><div class="css-1r7frvz"><div class="css-lm0pdr"><span style="font-size:0;line-height:0"></span><figure class="css-1e4ja14 css-f0t0lw"><a class="css-j5n0jw" data-event="engagement|bottom page content promo click|/health/birth-control-and-bone-loss;engagement|bottom page content promo click index|8" data-element-event="INTERNAL LINK|FOOTER|Any Page|Read This Next|LINK|Can Birth Control Cause Bone Loss?|rn7" href="https://www.healthline.com/health/birth-control-and-bone-loss?utm_source=ReadNext" aria-label="image-link" data-ga4="Read Next button clicks" data-testid="image-link" aria-hidden="true" tabindex="-1"><div class="css-79elbk"><span class="css-rwmw5v css-1pf0x3y"><span class="css-1767n2d"><lazy-image alt="Can Birth Control Cause Bone Loss?" src="https://media.post.rvohealth.io/wp-content/uploads/2024/09/doctor-teenager-patient-showing-digital-tablet-x-ray-732x549-thumbnail.jpg" srcSet="https://media.post.rvohealth.io/wp-content/uploads/2024/09/doctor-teenager-patient-showing-digital-tablet-x-ray-732x549-thumbnail.jpg 200w" className="css-1lyqwde"></lazy-image></span></span><span class="css-1fb1nmp"><span class="css-a10gts"></span></span></div></a></figure><div class="css-u8uhak"><a class="css-sqa1yu" data-event="engagement|bottom page content promo click|/health/birth-control-and-bone-loss;engagement|bottom page content promo click index|8" data-element-event="INTERNAL LINK|FOOTER|Any Page|Read This Next|LINK|Can Birth Control Cause Bone Loss?|rn7" href="https://www.healthline.com/health/birth-control-and-bone-loss?utm_source=ReadNext" data-testid="title-link" data-ga4="Read Next button clicks">Can Birth Control Cause Bone Loss?</a><section data-testid="byline" class="css-8he51f"><div class="css-1pz7193"><div class="css-quwpxp"><lazy-image alt="" src="https://media.post.rvohealth.io/wp-content/uploads/2022/01/Valinda-Riggins-Nwadike-500x500-Bio.png"></lazy-image></div></div><div><span><span>Medically reviewed by <a class="css-1c2ok3c css-ro87dg" href="https://www.healthline.com/medical-team">Valinda Riggins Nwadike, MD, MPH</a></span></span></div></section><p class=""><a class="css-onvglr" data-event="engagement|bottom page content promo click|/health/birth-control-and-bone-loss;engagement|bottom page content promo click index|8" data-element-event="INTERNAL LINK|FOOTER|Any Page|Read This Next|LINK|Can Birth Control Cause Bone Loss?|rn7" href="https://www.healthline.com/health/birth-control-and-bone-loss?utm_source=ReadNext" data-testid="text-link" data-ga4="Read Next button clicks" aria-hidden="true" tabindex="-1">Some birth control methods have been linked with reduced bone density. The risk may be greater in people who start taking them during adolescence.</a></p><a class="css-v5yzal css-ysgmro" data-event="engagement|bottom page content promo click|/health/birth-control-and-bone-loss;engagement|bottom page content promo click index|8" data-element-event="INTERNAL LINK|FOOTER|Any Page|Read This Next|LINK|Can Birth Control Cause Bone Loss?|rn7" href="https://www.healthline.com/health/birth-control-and-bone-loss?utm_source=ReadNext" data-ga4="Read Next button clicks">READ MORE<span class="icon-hl-arrow-right selector css-2kgwd5"></span></a></div></div></div><section class="css-82r5pg css-1ub4i5m"></section></div></div></li></ul></div></div></div><span class="css-zya54r"></span><span class="css-zya54r"></span></div><div class="css-i9gxme"></div><footer class="css-1dytfcg"><div class="css-1dppxl0"><hl-social-nav></hl-social-nav><div class="css-1b2ri56"><div class="css-uktbta css-ck5ydc"><hl-newsletter-cta buttonText="SIGN UP" source="footer_widget" subscribeEventTracking="Newsletter Acquisition|footer_widget|submit" className="css-13njx2h" category="Newsletter Acquisition" formatType="footer" name="footer_widget" productId="footer_widget" variant="footer_widget"></hl-newsletter-cta></div><div class="css-uktbta"><div class="css-1xceiwh"><div class="css-10ohy14"><ul class="css-lb03wr css-3o9pqj"><li class="css-34bq4y"><a class="css-1qz7cpo" href="https://www.healthline.com/about">About Us</a></li><li class="css-34bq4y"><a class="css-1qz7cpo" href="https://www.healthline.com/about/contact-us">Contact Us</a></li><li class="css-34bq4y"><a class="css-1qz7cpo" href="https://www.healthline.com/privacy-policy">Privacy Policy</a></li><li class="css-34bq4y"><button id="privacy-settings-one-trust" title="Privacy Settings" class="css-159kw12">Privacy Settings</button></li><li class="css-34bq4y"><a class="css-1qz7cpo" href="https://www.healthline.com/advertising-policy">Advertising Policy</a></li><li class="css-34bq4y"><a class="css-1qz7cpo" href="https://www.healthline.com/directory/topics">Health Topics</a></li></ul><ul class="css-lb03wr css-upe1zs"><li class="css-34bq4y"><a class="css-1qz7cpo" href="https://www.healthline.com/sitemap">Sitemap</a></li><li class="css-34bq4y"><a class="css-1qz7cpo" href="https://www.healthline.com/medical-team">Medical Affairs</a></li><li class="css-34bq4y"><a class="css-1qz7cpo" href="https://www.healthline.com/about/content-integrity">Content Integrity</a></li><li class="css-34bq4y"><a class="css-1qz7cpo" href="https://www.healthline.com/newsletter-signup">Newsletters</a></li><li class="css-34bq4y css-jwb353"><div class="css-16bllps css-1xdhyk6">© 2024 Healthline Media LLC. 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We fact-check health claims, evaluate ingredients, and look into each brand’s reputation before sharing products and services on Healthline.\u003c/p\u003e\u003cp\u003eTo choose the products on this page, we considered all the prenatal vitamins that passed our vetting process. Then, we personally tested some of them to narrow down our list even further.\u003c/p\u003e"},"probiotics":{"metrics":[{"description":"vitamins, minerals, and supplements evaluated","count":"1320+"},{"description":"probiotic supplements evaluated","count":"55"},{"description":"probiotic brands evaluated","count":"35"}],"explanationTitle":"How we evaluate probiotics","explanationDescription":"\u003cp\u003eOur \u003ca href=\"https://www.healthline.com/about/vet-brands-and-products\"\u003eMedical Standards and Insights team\u003c/a\u003e has carefully researched and vetted over 11,000 products and services. We fact-check health claims, evaluate ingredients, and look into each brand’s reputation before sharing products and services on Healthline.\u003c/p\u003e\u003cp\u003eTo choose the products on this page, we considered all the probiotics that passed our vetting process. Then, we personally tested some of them to narrow down our list even further.\u003c/p\u003e"},"vitamin-d":{"metrics":[{"description":"vitamins, minerals, and supplements evaluated","count":"1320+"},{"description":"vitamin D supplements evaluated","count":"40+"},{"description":"vitamin D brands evaluated","count":"25+"}],"explanationTitle":"How we evaluate vitamin D supplements","explanationDescription":"\u003cp\u003eOur \u003ca href=\"https://www.healthline.com/about/vet-brands-and-products\"\u003eMedical Standards and Insights team\u003c/a\u003e has carefully researched and vetted over 11,000 products and services. We fact-check health claims, evaluate ingredients, and look into each brand’s reputation before sharing products and services on Healthline.\u003c/p\u003e\u003cp\u003eTo choose the products on this page, we considered all the vitamin D supplements that passed our vetting process. Then, we personally tested some of them to narrow down our list even further.\u003c/p\u003e"},"creatine":{"metrics":[{"description":"creatine supplements evaluated by our medical standards team","count":"35"},{"description":"creatine supplements met our criteria","count":"28"},{"description":"creatine supplements personally tested by our team","count":"9"}],"explanationTitle":"How we evaluate creatine supplements","explanationDescription":"\u003cp\u003eOur \u003ca href=\"https://www.healthline.com/about/vet-brands-and-products\"\u003eMedical Standards and Insights team\u003c/a\u003e has carefully researched and vetted over 11,000 products and services. We fact-check health claims, evaluate ingredients, and look into each brand’s reputation before sharing products and services on Healthline.\u003c/p\u003e\u003cp\u003eTo choose the products on this page, we considered all the creatine supplements that passed our vetting process. Then, we personally tested some of them to narrow down our list even further.\u003c/p\u003e"},"mattresses":{"metrics":[{"description":"mattresses evaluated","count":"250+"},{"description":"mattress brands evaluated","count":"80+"}],"explanationTitle":"How we evaluate mattresses","explanationDescription":"\u003cp\u003eOur \u003ca href=\"https://www.healthline.com/about/vet-brands-and-products\"\u003eMedical Standards and Insights team\u003c/a\u003e has carefully researched and vetted over 11,000 products and services. We fact-check health claims, evaluate materials, and look into each brand’s reputation before sharing products and services on Healthline.\u003c/p\u003e\u003cp\u003eTo choose the products on this page, we considered all the mattresses that passed our vetting process. Then, we \u003ca href=\"https://www.healthline.com/health/sleep/healthline-scores-how-we-rate-mattresses\"\u003escored each mattress\u003c/a\u003e to narrow down our list even further.\u003c/p\u003e"},"pillows":{"metrics":[{"description":"pillows evaluated","count":"210"},{"description":"pillow brands evaluated","count":"140+"}],"explanationTitle":"How we evaluate pillows","explanationDescription":"\u003cp\u003eOur \u003ca href=\"https://www.healthline.com/about/vet-brands-and-products\"\u003eMedical Standards and Insights team\u003c/a\u003e has carefully researched and vetted over 11,000 products and services. We fact-check health claims, evaluate materials, and look into each brand’s reputation before sharing products and services on Healthline.\u003c/p\u003e\u003cp\u003eTo choose the products on this page, we considered all the pillows that passed our vetting process.\u003c/p\u003e"},"ed-telehealth":{"metrics":[{"description":"telehealth companies evaluated","count":"200+"},{"description":"online ED treatment providers evaluated","count":"20+"}],"explanationTitle":"How we evaluate online ED services","explanationDescription":"\u003cp\u003eOur \u003ca href=\"https://www.healthline.com/about/vet-brands-and-products\"\u003eMedical Standards and Insights team\u003c/a\u003e has carefully researched and vetted over 11,000 products and services. We evaluate services for consistency with standards of care and best practices, and we look into each brand’s reputation before sharing products and services on Healthline.\u003c/p\u003e\u003cp\u003eTo choose the services on this page, we considered all the ED treatment services that passed our vetting process. Then, we \u003ca href=\"https://www.healthline.com/health/healthline-scores-how-we-evaluate-mens-telehealth-platforms\"\u003escored each service\u003c/a\u003e to narrow down our list even further.\u003c/p\u003e"},"birth-control-telehealth":{"metrics":[{"description":"telehealth companies evaluated","count":"200+"},{"description":"online birth control providers evaluated","count":"14"}],"explanationTitle":"How we evaluate online birth control services","explanationDescription":"\u003cp\u003eOur \u003ca href=\"https://www.healthline.com/about/vet-brands-and-products\"\u003eMedical Standards and Insights team\u003c/a\u003e has carefully researched and vetted over 11,000 products and services. We evaluate services for consistency with standards of care and best practices, and we look into each brand’s reputation before sharing products and services on Healthline.\u003c/p\u003e\u003cp\u003eTo choose the services on this page, we considered all the birth control services that passed our vetting process. Then, we \u003ca href=\"https://www.healthline.com/health/how-we-review-birth-control\"\u003escored each service\u003c/a\u003e to narrow down our list even further.\u003c/p\u003e"},"hemp":{"metrics":[{"description":"hemp brands evaluated","count":"230+"},{"description":"hemp brands met our criteria","count":"57"},{"description":"hemp brands we've personally tested","count":"30+"}],"explanationTitle":"How we evaluate hemp products","explanationDescription":"\u003cp\u003eOur Medical Standards and Insights team has carefully researched and vetted over 11,000 products and services. We fact-check health claims, evaluate ingredients, and look into each brand’s reputation before sharing products and services on Healthline. The brand we feature in this article has passed our strict vetting process and has been thoroughly tested by our reviewers. \u003ca href=\"https://www.healthline.com/about/vet-brands-and-products\"\u003eRead more about how we vet brands and products.\u003c/a\u003e\u003c/p\u003e"}},"isPrependRecipeH2":false,"recipes":[],"hideTabs":false,"tabs":[{"id":"_noHeaderPrefixedContent","title":null,"header":null,"body":[{"tagName":"p","attributes":{"className":"responsive"},"source":"While you read this article, your body is busy at work: Chemicals are being secreted from glands, organs, and tissues, sending messages that direct your body to react in certain ways. These chemicals, called hormones, regulate everything from growth and reproduction to digestion and mental health. "},{"tagName":"div","attributes":{"data-preamp":"serena-chatbot"},"source":""},{"tagName":"p","attributes":{"className":"responsive"},"source":"\u003ca href=\"https://www.healthline.com/health/progesterone-function\" class=\"content-link css-1c2ok3c\"\u003eProgesterone\u003c/a\u003e and progestin are two hormones that you may have heard of. They have similar-sounding names, and it can be tricky to tell the difference between the two. However, the differences are important to know about. Read on to learn more about these important hormones and how they can affect our bodies. "}]},{"id":"similarity","title":"Similarity","isCollapsable":false,"header":["Is progesterone the same thing as progestin?"],"body":[{"tagName":"p","attributes":{"className":"responsive"},"source":"In short, yes and no: Progesterone is a \u003ca href=\"http://e.hormone.tulane.edu/learning/progestins.html\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"content-link css-1c2ok3c\"\u003enaturally occurring steroid\u003c/a\u003e hormone made in varying amounts by male, female, and intersex bodies. Progestin is a synthetic chemical that mimics the effects of progesterone on the body."},{"tagName":"p","source":"So-called “\u003ca href=\"https://www.healthline.com/health/natural-progesterone\" class=\"content-link css-1c2ok3c\"\u003enatural\u003c/a\u003e” or “bioidentical” progesterone medications also exist. This name is somewhat inaccurate, though: Progesterone medications are synthesized from a \u003ca href=\"https://pubchem.ncbi.nlm.nih.gov/compound/Diosgenin\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"content-link css-1c2ok3c\"\u003eplant chemical called diosgenin\u003c/a\u003e — which is found in wild yam."},{"tagName":"p","source":"In addition to creating progesterone for use in birth control, diosgenin is also commonly used to synthesize other steroid hormones that are used in medications, including \u003ca href=\"https://www.healthline.com/health/cortisone-shot\" class=\"content-link css-1c2ok3c\"\u003ecortisone\u003c/a\u003e, pregnenolone, and progesterone."}]},{"id":"functions","title":"Functions","isCollapsable":false,"header":["What do progesterone and progestin do in the body? "],"body":[{"tagName":"p","source":"Female and some intersex bodies naturally produce surges of progesterone after ovulation. This drives the second half of the\u003ca href=\"https://www.healthline.com/health/hormonal-imbalance-menstrual-cycle\" class=\"content-link css-1c2ok3c\"\u003e menstrual cycle\u003c/a\u003e, preparing the body to potentially grow an embryo from a fertilized egg."},{"tagName":"p","source":"If an egg is fertilized, the body will release even more progesterone to \u003ca href=\"https://www.healthline.com/health-news/giving-progesterone-during-pregnancy-could-prevent-miscarriage\" class=\"content-link css-1c2ok3c\"\u003esupport the fetus during pregnancy\u003c/a\u003e. During pregnancy, progesterone ensures the womb grows and prevents premature contractions (which can lead to \u003ca href=\"https://www.healthline.com/health/miscarriage\" class=\"content-link css-1c2ok3c\"\u003emiscarriage\u003c/a\u003e)."},{"tagName":"p","attributes":{"className":"responsive"},"source":"In male and other intersex bodies, progesterone is produced in lower quantities. In these bodies progesterone plays an important role in sperm development, maintaining \u003ca href=\"https://www.healthline.com/health/low-testosterone/testosterone-levels-by-age\" class=\"content-link css-1c2ok3c\"\u003etestosterone levels\u003c/a\u003e, and other body functions."},{"tagName":"p","attributes":{"className":"responsive"},"source":"When a person’s progesterone levels are high, they \u003ca href=\"https://medlineplus.gov/druginfo/meds/a604017.html\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"content-link css-1c2ok3c\"\u003emay experience\u003c/a\u003e: "},{"tagName":"ul","source":"\u003cli\u003e\u003ca href=\"https://www.healthline.com/health/hormones-weight-gain-pov#1\" class=\"content-link css-1c2ok3c\"\u003eweight gain\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href=\"https://www.healthline.com/health/causes-of-mood-swing\" class=\"content-link css-1c2ok3c\"\u003emoodiness\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href=\"https://www.healthline.com/health/depression/menstrual-depression\" class=\"content-link css-1c2ok3c\"\u003edepression\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href=\"https://www.healthline.com/health/birth-control/can-birth-control-make-you-tired\" class=\"content-link css-1c2ok3c\"\u003efatigue\u003c/a\u003e\u003c/li\u003e"},{"tagName":"p","attributes":{"className":"responsive"},"source":"When levels are \u003ca href=\"https://medlineplus.gov/druginfo/meds/a604017.html\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"content-link css-1c2ok3c\"\u003etoo low\u003c/a\u003e, they may lead to \u003ca href=\"https://www.healthline.com/health/menstrual-periods-heavy-prolonged-or-irregular\" class=\"content-link css-1c2ok3c\"\u003eirregular periods\u003c/a\u003e, anxiety, \u003ca href=\"https://www.healthline.com/health/hormonal-headaches\" class=\"content-link css-1c2ok3c\"\u003eheadaches\u003c/a\u003e, and depression. People with low progesterone levels may have difficulty getting pregnant and keeping a pregnancy. What a normal progesterone level is for a person depends on their age, sex, gender, and individual health status."}]},{"id":"differences","title":"Differences","isCollapsable":false,"header":["Progestin vs. progesterone vs. progestogen: What’s the difference? "],"body":[{"tagName":"p","attributes":{"className":"responsive"},"source":"Two types of progesterone medications emerged during the early development of birth control pills in the 1950s and 1960s. This includes \u003chl-trusted-source source=\"BMC/BioMed Central\" rationale=\"Peer reviewed journal\"\u003e\u003ca href=\"https://contraceptionmedicine.biomedcentral.com/articles/10.1186/s40834-020-00142-5\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"content-link css-1c2ok3c\"\u003eprogestin\u003c/a\u003e\u003c/hl-trusted-source\u003e, a type of synthetic (human-made) steroid hormone that’s still popularly used in birth control pills. "},{"tagName":"p","attributes":{"className":"responsive"},"source":"Progestins work similarly to progesterone in the body, but each type of synthetic progestin has its own effects on the body and may be used to treat different conditions."},{"tagName":"p","attributes":{"className":"responsive"},"source":"In addition to its key use in \u003ca href=\"https://www.healthline.com/health/birth-control-without-estrogen\" class=\"content-link css-1c2ok3c\"\u003eprogestin-only birth control\u003c/a\u003e “mini-pills” and combination estrogen-progestin birth control pills, the common uses for progestins are to treat irregular menstrual periods, including amenorrhea and abnormal bleeding. Some \u003ca href=\"https://www.sciencedirect.com/topics/neuroscience/progestin\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"content-link css-1c2ok3c\"\u003eothers include\u003c/a\u003e:"},{"tagName":"ul","source":"\u003cli\u003etreating certain cancers that react to hormones\u003c/li\u003e\u003cli\u003eproviding \u003ca href=\"https://www.healthline.com/health/what-is-gender-affirming-care\" class=\"content-link css-1c2ok3c\"\u003egender-affirming therapy\u003c/a\u003e\u003c/li\u003e\u003cli\u003ealleviating \u003ca href=\"https://www.healthline.com/health/menopause/symptoms-signs\" class=\"content-link css-1c2ok3c\"\u003esymptoms of menopause\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href=\"https://www.healthline.com/health/managing-osteoporosis/can-osteoporosis-be-reversed\" class=\"content-link css-1c2ok3c\"\u003eslowing bone loss\u003c/a\u003e\u003c/li\u003e\u003cli\u003epart of fertility treatments \u003c/li\u003e"},{"tagName":"p","attributes":{"className":"responsive"},"source":"Progestin medications \u003ca href=\"https://www.sciencedirect.com/topics/neuroscience/progestin\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"content-link css-1c2ok3c\"\u003emay come in\u003c/a\u003e pill, gel, cream, injection, transdermal patch, or suppository form, depending on its use."}]},{"id":"safety","title":"Safety ","isCollapsable":false,"header":["Is progestin good for you? "],"body":[{"tagName":"p","attributes":{"className":"responsive"},"source":"For some people, progestin may be the best available medication to address their needs. In other cases, people may choose between progestin and progesterone medications. "},{"tagName":"p","attributes":{"className":"responsive"},"source":"Some progesterone medications, such as topical creams, can be bought over the counter to address some of the \u003ca href=\"https://www.healthline.com/health/menopause\" class=\"content-link css-1c2ok3c\"\u003esymptoms of menopause\u003c/a\u003e. The side effects of both progestin and progesterone are similar. For both types of medications, it’s important to follow dosage directions to avoid potentially serious adverse side effects."},{"tagName":"p","attributes":{"className":"responsive"},"source":"Compare the \u003ca href=\"https://www.sciencedirect.com/topics/neuroscience/progestin\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"content-link css-1c2ok3c\"\u003eside effects\u003c/a\u003e of progesterone medications and progestin medications:"},{"tagName":"div","attributes":{"className":"scrollTable css-1iwt4bv"},"source":"\u003ctable class=\"responsive css-1pp4cxb\"\u003e\u003ctbody\u003e\u003ctr\u003e\u003ctd\u003e\u003cstrong\u003eProgestin\u003c/strong\u003e\u003c/td\u003e\u003ctd\u003e\u003cstrong\u003eProgesterone\u003c/strong\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd\u003eincreased risk of \u003ca href=\"https://academic.oup.com/edrv/article/41/2/320/5568276\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"content-link css-1c2ok3c\"\u003ebreast cancer\u003c/a\u003e\u003c/td\u003e\u003ctd\u003eincreased \u003chl-trusted-source source=\"PubMed Central\" rationale=\"Highly respected database from the National Institutes of Health\"\u003e\u003ca href=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960754/\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"content-link css-1c2ok3c\"\u003erisk of tumors\u003c/a\u003e\u003c/hl-trusted-source\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd\u003echanges in menstrual bleeding\u003c/td\u003e\u003ctd\u003edepression\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd\u003ebreast tenderness\u003c/td\u003e\u003ctd\u003ebreast tenderness\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd\u003eheadaches\u003c/td\u003e\u003ctd\u003eheadaches\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd\u003enausea\u003c/td\u003e\u003ctd\u003eskin reactions\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd\u003e\u003chl-trusted-source source=\"JAMA\" rationale=\"Highly respected journal,Expert written journal,Peer reviewed journal\"\u003e\u003ca href=\"https://jamanetwork.com/journals/jama/article-abstract/201922\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"content-link css-1c2ok3c\"\u003eincreased risk\u003c/a\u003e\u003c/hl-trusted-source\u003e of blood clots for newer progestins \u003c/td\u003e\u003ctd\u003eincreased risk of blood clotting\u003c/td\u003e\u003c/tr\u003e\u003c/tbody\u003e\u003c/table\u003e"},{"widget":{"widgetFormat":"widget-call-out","items":[{"headerTitle":["Don’t forget! "],"content":[{"tagName":"p","attributes":{"className":"standout--body"},"source":"While these treatments can be lifesaving, they can also have dangerous side effects. Always follow your doctor’s dosing instructions for any hormonal treatment carefully and discuss any new symptoms with them as soon as possible."}]}]},"brandPage":{}}]},{"id":"treatments","title":"Treatments","isCollapsable":false,"header":["Synthetic progesterone is used in a variety of medical treatments"],"body":[{"tagName":"p","attributes":{"className":"responsive"},"source":"The majority of progesterone-like medications on the market today are made of progestin. However, a growing number of progestin medications are on the market, including a few that have been approved by the FDA."},{"tagName":"h3","attributes":{"className":"responsive"},"source":"Progestin vs. progesterone: uses in birth control "},{"tagName":"p","attributes":{"className":"responsive"},"source":"Progestin is more commonly used than progesterone in \u003ca href=\"https://www.acog.org/womens-health/faqs/progestin-only-hormonal-birth-control-pill-and-injection\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"content-link css-1c2ok3c\"\u003evarious forms of birth control\u003c/a\u003e, including the hormonal IUD, pill, and injection. "},{"tagName":"p","attributes":{"className":"responsive"},"source":"In these uses, progestin thickens the mucus of the cervix so that sperm can’t enter to fertilize an egg. It also thickens the lining of the uterus, controlling bleeding, and can sometimes stop ovulation."},{"tagName":"p","attributes":{"className":"responsive"},"source":"Some progestins are mixed with estrogens to produce combined birth control pills that prevent pregnancy by preventing ovulation. These pills carry a risk of blood clots for people over age 35, especially if they smoke."},{"tagName":"h3","attributes":{"className":"responsive"},"source":"Progestin vs. progesterone: uses in menstrual cycle treatment"},{"tagName":"p","attributes":{"className":"responsive"},"source":"One \u003chl-trusted-source source=\"BMC/BioMed Central\" rationale=\"Peer reviewed journal\"\u003e\u003ca href=\"https://contraceptionmedicine.biomedcentral.com/articles/10.1186/s40834-020-00142-5\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"content-link css-1c2ok3c\"\u003erecent study\u003c/a\u003e\u003c/hl-trusted-source\u003e notes that women are increasingly looking for progestin-based pills, injections, and IUDs to control or stop menstrual bleeding."},{"tagName":"p","attributes":{"className":"responsive"},"source":"Progestin is also used to treat \u003ca href=\"https://www.healthline.com/health/polycystic-ovary-disease\" class=\"content-link css-1c2ok3c\"\u003epolycystic ovarian syndrome\u003c/a\u003e (PCOS). However, due to the wide availability of bioidentical progesterones on the market, many people use over-the-counter progesterone creams to help regulate irregular periods."},{"tagName":"h3","attributes":{"className":"responsive"},"source":"Progestin vs. progesterone: uses in fertility treatment"},{"tagName":"p","attributes":{"className":"responsive"},"source":"Bioidentical progesterones are now popularly used in fertility treatments. Many products are now on the market, from creams to pills. However, little research exists on the efficacy of many of these treatments."},{"tagName":"h3","attributes":{"className":"responsive"},"source":"Progestin vs. progesterone: uses in menopause symptom treatment "},{"tagName":"p","attributes":{"className":"responsive"},"source":"In treating menopause symptoms, including \u003ca href=\"https://www.tandfonline.com/doi/full/10.1080/13697137.2018.1467400\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"content-link css-1c2ok3c\"\u003ebone loss\u003c/a\u003e, progestin is a commonly prescribed medication. However, over-the-counter progesterone creams and supplements are growing in popularity. "},{"tagName":"p","attributes":{"className":"responsive"},"source":"\u003ca href=\"https://www.tandfonline.com/doi/abs/10.1080/13697137.2018.1476483\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"content-link css-1c2ok3c\"\u003eResearch suggests\u003c/a\u003e several risks of taking progestins for menopause symptoms, including the risk of serious adverse side effects — such as \u003ca href=\"https://www.healthline.com/health/symptoms-and-complications-blood-clots\" class=\"content-link css-1c2ok3c\"\u003eblood clots\u003c/a\u003e and heart problems — in some older people."},{"tagName":"h3","attributes":{"className":"responsive"},"source":"Progestin vs. progesterone: uses in gender-affirming care"},{"tagName":"p","attributes":{"className":"responsive"},"source":"While it has been overlooked in the past, experts now believe progesterone can play an important role in gender-affirming therapy when combined with estrogen for people looking to increase their body’s feminization."},{"tagName":"p","attributes":{"className":"responsive"},"source":"\u003chl-trusted-source source=\"PubMed Central\" rationale=\"Highly respected database from the National Institutes of Health\"\u003e\u003ca href=\"https://pubmed.ncbi.nlm.nih.gov/30608551/\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"content-link css-1c2ok3c\"\u003eEvidence shows\u003c/a\u003e\u003c/hl-trusted-source\u003e that adding progesterone medication to a person’s \u003ca href=\"https://www.healthline.com/health/what-is-gender-affirming-care\" class=\"content-link css-1c2ok3c\"\u003egender-affirming care\u003c/a\u003e can lead to the development of feminine secondary sex characteristics faster than estrogen alone, as well as: "},{"tagName":"ul","source":"\u003cli\u003ediminish testosterone production\u003c/li\u003e\u003cli\u003eincrease bone mass\u003c/li\u003e\u003cli\u003e\u003ca href=\"https://www.healthline.com/health/best-time-to-sleep\" class=\"content-link css-1c2ok3c\"\u003eimprove sleep\u003c/a\u003e\u003c/li\u003e\u003cli\u003ebenefit their heart health\u003c/li\u003e"},{"widget":{"widgetFormat":"widget-call-out","items":[{"headerTitle":["Is progestin cream as effective as progesterone cream?"],"content":[{"tagName":"p","attributes":{"className":"standout--body"},"source":"Progesterone cream is typically not made of progestin. "},{"tagName":"p","attributes":{"className":"standout--body"},"source":"Instead, creams \u003ca href=\"https://medlineplus.gov/druginfo/meds/a604017.html\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"content-link css-1c2ok3c\"\u003ecommonly contain\u003c/a\u003e bioidentical progesterone to increase fertility, regulate the menstrual cycle, and alleviate symptoms of menopause. Some prescription progesterone gels also exist to treat infertility."}]}]},"brandPage":{}}]},{"id":"takeaway","title":"Takeaway","isCollapsable":false,"header":["Takeaway"],"body":[{"tagName":"p","attributes":{"className":"responsive"},"source":"Progestin and progesterone are two kinds of steroid medications used in care for menstrual issues, menopause symptoms, fertility issues, and gender-affirming therapies. "},{"tagName":"p","attributes":{"className":"responsive"},"source":"While they have similar names, progestin refers to a synthesized chemical that acts similarly to natural progesterone in the body. Progesterone medications aren’t made from human chemicals but from plants. They also act similarly to progesterone in the body."},{"tagName":"p","attributes":{"className":"responsive"},"source":"The kind of progesterone medication you might use depends on your needs and medical history. Talk with your doctor to \u003ca href=\"https://www.healthline.com/health/progesterone-for-menopause\" class=\"content-link css-1c2ok3c\"\u003elearn more about your options\u003c/a\u003e."}]}],"hasAffiliateLinks":false,"affiliates":[],"propsFor":{"articleResources":[{"displayLink":"ncbi.nlm.nih.gov/pmc/articles/PMC4960754/","link":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960754/","title":{"tagName":"span","source":"Asi N, et al. (2016). 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Progesterone receptor ligands for the treatment of endometriosis: the mechanisms behind therapeutic success and failure."}},{"displayLink":"contraceptionmedicine.biomedcentral.com/articles/10.1186/s40834-020-00142-5","link":"https://contraceptionmedicine.biomedcentral.com/articles/10.1186/s40834-020-00142-5","title":{"tagName":"span","source":"Shoupe D. (2021). The Progestin revolution: Progestins are arising as the dominant players in the tight interlink between contraceptives and bleeding control."}},{"displayLink":"e.hormone.tulane.edu/learning/progestins.html","link":"http://e.hormone.tulane.edu/learning/progestins.html","title":{"tagName":"span","source":"The hormones: Progestins. (n.d.)."}},{"displayLink":"academic.oup.com/edrv/article/41/2/320/5568276","link":"https://academic.oup.com/edrv/article/41/2/320/5568276","title":{"tagName":"span","source":"Trabert B, et al. (2019). 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