Top Breakthroughs In Aging Research - American Federation for Aging Research

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section--bgclr color-blue section--bgimg"> <div class="section__bg section__bg--img poster inlay__bg--block-764159"></div> <style> .inlay__bg--block-764159 { background-image: url(/imager/sciencebackgroundphotos/245683/GlowLabOlderFemale_b616f0dd1c9e12ac293f80067c1526ee.JPG); } @media (max-width: 1024px) { .inlay__bg--block-764159 { background-image: url(/imager/sciencebackgroundphotos/245683/GlowLabOlderFemale_775dfc64901f4612608e87a7497e295b.JPG); } } @media (max-width: 480px) { .inlay__bg--block-764159 { background-image: url(/imager/sciencebackgroundphotos/245683/GlowLabOlderFemale_4de3145e4a5f7b68a5e3a7333ae49011.JPG); } } </style> <div class="section__bg section__bg--clr"></div> <div class="section__inner section__pad"> <div class="shell"> <div class="grid grid--xs"> <div class="grid__inner"> <div class="grid-item grid-item--full"> <div class="component component--inherit "> <div class="inlay"> <div class="shadow"></div> <div class="inlay__bg inlay__bg--img component__bgimg poster inlay__bg--block-764159"></div> <div class="inlay__bg inlay__bg--clr component__bgclr"></div> <div class="inlay__inner"> <div class="article color-blue"> <div class="article__inner component__cols"> <div class="article__main" data-aos="fade-up"> <h1>Top Breakthroughs in Aging Research</h1><h2>Driven by AFAR Experts</h2><p>With AFAR’s support, science has led to innumerable discoveries that are bringing us closer to the development of therapies that will extend healthspan, or our years of health as we age. <br /></p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="section section--band section--padxs-top "> <div class="section__bg section__bg--clr"></div> <div class="section__inner section__pad "> <div class="shell"> <div class="grid grid--sm"> <div class="grid__inner grid__inner--two-columns"> <div class="grid-item grid-item--custom grid-item--left grid-item--card-wide"> <div class="component component--separator color-yellow"> <div class="card card--wide"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload slider__image" data-src="/imager/general/243129/HumanCellsCloseUp_8c3db02c789aac09497d19c3bbf7ce48.jpg" alt="Human Cells Close Up"> <div class="separator color-yellow"></div> </div> <div class="card__inner"> <div class="card__content"> <h3>Senescent cells can be removed</h3> </div> <div class="card__actions component__actions"> <a href="#senescentcells" class="color-yellow"></a> </div> </div> <a href="#senescentcells" class="card__link component__link" target=""></a> </div> </div> </div> <div class="grid-item grid-item--custom grid-item--right grid-item--card-wide"> <div class="component component--separator color-yellow"> <div class="card card--wide"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload slider__image" data-src="/imager/sciencebackgroundphotos/244893/ExerciseShoe_8c3db02c789aac09497d19c3bbf7ce48.jpg" alt="Exercise Shoe"> <div class="separator color-yellow"></div> </div> <div class="card__inner"> <div class="card__content"> <h3>Exercise has cellular and cognitive benefits</h3> </div> <div class="card__actions component__actions"> <a href="#exercise" class="color-yellow"></a> </div> </div> <a href="#exercise" class="card__link component__link" target=""></a> </div> </div> </div> </div> </div> </div> </div> </div> <div class="section section--band section--padxs-top "> <div class="section__bg section__bg--clr"></div> <div class="section__inner section__pad "> <div class="shell"> <div class="grid grid--sm"> <div class="grid__inner grid__inner--two-columns"> <div class="grid-item grid-item--custom grid-item--left grid-item--card-wide"> <div class="component component--separator color-yellow"> <div class="card card--wide"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload slider__image" data-src="/imager/general/21480/Plate_8c3db02c789aac09497d19c3bbf7ce48.jpg" alt="Breakthroughs - Plate"> <div class="separator color-yellow"></div> </div> <div class="card__inner"> <div class="card__content"> <h3>Restricting certain foods--without restricting calories--can increase healthspan</h3> </div> <div class="card__actions component__actions"> <a href="#food" class="color-yellow"></a> </div> </div> <a href="#food" class="card__link component__link" target=""></a> </div> </div> </div> <div class="grid-item grid-item--custom grid-item--right grid-item--card-wide"> <div class="component component--separator color-yellow"> <div class="card card--wide"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload slider__image" data-src="/imager/general/243395/RedBloodCells_8c3db02c789aac09497d19c3bbf7ce48.jpg" alt="Red Blood Cells"> <div class="separator color-yellow"></div> </div> <div class="card__inner"> <div class="card__content"> <h3>Young blood had rejuvenating properties</h3> </div> <div class="card__actions component__actions"> <a href="#youngblood" class="color-yellow"></a> </div> </div> <a href="#youngblood" class="card__link component__link" target=""></a> </div> </div> </div> </div> </div> </div> </div> </div> <div class="section section--band section--padxs-top "> <div class="section__bg section__bg--clr"></div> <div class="section__inner section__pad "> <div class="shell"> <div class="grid grid--sm"> <div class="grid__inner grid__inner--two-columns"> <div class="grid-item grid-item--custom grid-item--left grid-item--card-wide"> <div class="component component--separator color-yellow"> <div class="card card--wide"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload slider__image" data-src="/imager/general/246386/Proteincelll-2_8c3db02c789aac09497d19c3bbf7ce48.jpg" alt="Proteincelll 2"> <div class="separator color-yellow"></div> </div> <div class="card__inner"> <div class="card__content"> <h3>Preventing protein aggregation can preserve health</h3> </div> <div class="card__actions component__actions"> <a href="#protein" class="color-yellow"></a> </div> </div> <a href="#protein" class="card__link component__link" target=""></a> </div> </div> </div> <div class="grid-item grid-item--custom grid-item--right grid-item--card-wide"> <div class="component component--separator color-yellow"> <div class="card card--wide"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload slider__image" data-src="/imager/sciencebackgroundphotos/244278/FingerPillTightCrop_8c3db02c789aac09497d19c3bbf7ce48.jpg" alt="Finger Pill Tight Crop"> <div class="separator color-yellow"></div> </div> <div class="card__inner"> <div class="card__content"> <h3>Drugs have been discovered that extend life in mice</h3> </div> <div class="card__actions component__actions"> <a href="#drugs" class="color-yellow"></a> </div> </div> <a href="#drugs" class="card__link component__link" target=""></a> </div> </div> </div> </div> </div> </div> </div> </div> <div class="section section--band section--padxs-top section--padxs-bottom "> <div class="section__bg section__bg--clr"></div> <div class="section__inner section__pad "> <div class="shell"> <div class="grid grid--sm"> <div class="grid__inner grid__inner--two-columns"> <div class="grid-item grid-item--custom grid-item--left grid-item--card-wide"> <div class="component component--separator color-yellow"> <div class="card card--wide"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload slider__image" data-src="/imager/general/246789/XX-Chromosome_8c3db02c789aac09497d19c3bbf7ce48.jpg" alt="XX Chromosome"> <div class="separator color-yellow"></div> </div> <div class="card__inner"> <div class="card__content"> <h3>Biological processes of aging may differ between sexes</h3> </div> <div class="card__actions component__actions"> <a href="#sexes" class="color-yellow"></a> </div> </div> <a href="#sexes" class="card__link component__link" target=""></a> </div> </div> </div> <div class="grid-item grid-item--custom grid-item--right grid-item--card-wide"> <div class="component component--separator color-yellow"> <div class="card card--wide"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload slider__image" data-src="/imager/general/599267/Reprorgramming_A_8c3db02c789aac09497d19c3bbf7ce48.jpg" alt="Reprorgramming A"> <div class="separator color-yellow"></div> </div> <div class="card__inner"> <div class="card__content"> <h3>Cells can be reprogrammed to restore function</h3> </div> <div class="card__actions component__actions"> <a href="#reprogramming" class="color-yellow"></a> </div> </div> <a href="#reprogramming" class="card__link component__link" target=""></a> </div> </div> </div> </div> </div> </div> </div> </div> <div class="section section--band section--padxs-top section--padxs-bottom "> <div class="section__bg section__bg--clr"></div> <div class="section__inner section__pad "> <div class="shell"> <div class="grid grid--sm"> <div class="grid__inner grid__inner--two-columns"> <div class="grid-item grid-item--custom grid-item--left grid-item--card-wide"> <div class="component component--separator color-yellow"> <div class="card card--wide"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload slider__image" data-src="/imager/general/599276/BioMarkers_8c3db02c789aac09497d19c3bbf7ce48.jpg" alt="Bio Markers"> <div class="separator color-yellow"></div> </div> <div class="card__inner"> <div class="card__content"> <h3>Reliable markers of biological age are here</h3> </div> <div class="card__actions component__actions"> <a href="#biomarkers" class="color-yellow"></a> </div> </div> <a href="#biomarkers" class="card__link component__link" target=""></a> </div> </div> </div> <div class="grid-item grid-item--card-wide"> </div> </div> </div> </div> </div> </div> <div class="jump-link-anchor" id="senescentcells"></div><div class="section section--padsm-top section--padxs-bottom section--bgclr color-blue section--bgimg"> <div class="section__bg section__bg--img poster inlay__bg--block-764184"></div> <style> .inlay__bg--block-764184 { background-image: url(/imager/general/243131/HumanCellsCloseUp_200123_175020_b616f0dd1c9e12ac293f80067c1526ee.jpg); } @media (max-width: 1024px) { .inlay__bg--block-764184 { background-image: url(/imager/general/243131/HumanCellsCloseUp_200123_175020_775dfc64901f4612608e87a7497e295b.jpg); } } @media (max-width: 480px) { .inlay__bg--block-764184 { background-image: url(/imager/general/243131/HumanCellsCloseUp_200123_175020_4de3145e4a5f7b68a5e3a7333ae49011.jpg); } } </style> <div class="section__bg section__bg--clr"></div> <div class="section__inner section__pad"> <div class="shell"> <div class="grid grid--xs"> <div class="grid__inner"> <div class="grid-item grid-item--full"> <div class="component component--inherit "> <div class="inlay"> <div class="shadow"></div> <div class="inlay__bg inlay__bg--img component__bgimg poster inlay__bg--block-764184"></div> <div class="inlay__bg inlay__bg--clr component__bgclr"></div> <div class="inlay__inner"> <div class="article color-blue"> <div class="article__inner component__cols"> <div class="article__main" data-aos="fade-up"> <h2>Senescent cells do have a damaging impact as we age — but can be removed.</h2><p>These are cells that could once replicate to repair aging tissue but have now lost that capacity due to internal damage. It turns out that they degrade surrounding tissue bysecreting harmful molecules. A long-time controversy has been whether senescent cells really had any damaging impact on us. We now know that they do — and why. We also know that accumulated senescent cells can be removed.</p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="section section--bigbar section--padxs-top section--padxs-bottom"> <div class="section__inner section__pad"> <div class="shell"> <div class="section__cols"> <div class="section__main"> <div class="component"> <div class="inlay"> <div class="inlay__inner"> <div class="article article--avatar article--avatarwrap color-blue"> <div class="article__inner component__cols"> <div class="article__main clear"> <div class="avatar avatar--alt"> <div class="avatar__inner"> <div class="avatar__image"> <img class="lazyload" data-src="/imager/granteeprofileimages/16570/james-kirkland-headshot_6fef9ec64b256ad6bee8afabc362a09e.jpg" alt="James Kirkland"> </div> </div> </div> <div class="article__content" data-aos="fade-up"> <h4>James L. Kirkland, MD, PhD</h4><p>2012 <a href="https://www.afar.org/grants/big">Glenn/AFAR Breakthroughs in Gerontology (BIG) Award</a> recipient and <a href="https://www.afar.org/scientific-leadership">President-Elect</a> <strong>James L. Kirkland, MD, PhD</strong>, and his team the Mayo Clinic have been leading research on the first senolytic drugs since 2015. In 2018, he was senior author on a study that found that a combination of the leukemia drug dasatinib and the natural plant pigment, quercetin extended not just how long mice live, but also the time they live in good health. The first-ever small pilot trial in humans was completed in early 2019, paving the way for larger trials in the near future.<br /></p><p>Dr. Kirkland and several other AFAR experts have also identified another natural senolytic, Fisetin, which is also found in many fruits and vegetables. In animal studies, Dr. Kirkland and AFAR experts have found it was possible to reduce the burden of senescent cells, and extend lifespan and improve health, even when treatment was initiated late in life.</p> <div class="socials"> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="sidebar sidebar--big"> <div class="slider slider--embed slider--color color-blue"> <div class="slider__intro text-center"> <div class="shadow"></div> <h5>More from Dr. Kirkland</h5> </div> <div class="slider__inner"> <div class="grid swiper-container js-slider-embed"> <div class="grid__inner swiper-wrapper slider__slides"> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/general/243129/HumanCellsCloseUp_f7a9bdabdac5f4ef029b9375b1a4069f.jpg" alt="Human Cells Close Up"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <h5 class="color-yellow">Read</h5><p>Research in <em>JAMA Viewpoint </em> co-authored by Dr. Kirkland, "Aging, Cell Senescence, and Chronic Disease: Emerging Therapeutic Strategies."</p> </div> <div class="swiper-pagination"></div> </div> <a href="https://jamanetwork.com/journals/jama/article-abstract/2703113" class="card__link component__link" target="_blank"></a> </div> </div> </div> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/sciencebackgroundphotos/16132/iStock-513751952-copy_edc5ed543b0c9a80abfa97138acbdbae.jpg" alt="DNA iStock"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <h5 class="color-yellow">Read</h5><p><em>Science Daily</em> story on Senotheropeutic research led by Dr. Kirkland and other AFAR experts.</p> </div> <div class="swiper-pagination"></div> </div> <a href="http://www.sciencedaily.com/releases/2018/10/181002114024.htm" class="card__link component__link" target="_blank"></a> </div> </div> </div> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/events/605270/Kirkland_SenolyticsPres_London_f7a9bdabdac5f4ef029b9375b1a4069f.png" alt="Kirkland Senolytics Pres London"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <h5 class="color-yellow">Watch</h5><p>Dr. Kirkland presents Senolytics at Investing in the Age of Longevity 2021 in London. In his talk, James highlights inflammation, macromolecular/organelle dysfunction, stem cell and progenitor dysfunction, as well as cellular senescence as fundamental aging mechanisms. Presenting findings from research into the transplantation of senescent cells, Jim gives an overview of clinical trials of senolytics, and the emerging evidence for benefits of senolytics on a range of senescence- and age-related conditions.</p> </div> <div class="swiper-pagination"></div> </div> </div> </div> </div> </div> </div> <div class="slider-nav"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="section section--bigbar section--padxs-top "> <div class="section__inner section__pad"> <div class="shell"> <div class="section__cols"> <div class="section__main"> <div class="component"> <div class="inlay"> <div class="inlay__inner"> <div class="article article--avatar article--avatarwrap color-blue"> <div class="article__inner component__cols"> <div class="article__main clear"> <div class="avatar avatar--alt"> <div class="avatar__inner"> <div class="avatar__image"> <img class="lazyload" data-src="/imager/granteeprofileimages/16585/Campisi_6fef9ec64b256ad6bee8afabc362a09e.jpg" alt="Judy Campisi"> </div> </div> </div> <div class="article__content" data-aos="fade-up"> <h4><strong>Judy Campisi, PhD</strong><br /></h4><p>1990 <a href="https://www.afar.org/grants/mcknight-award">AFAR Research Grant for Junior Faculty</a> recipient <strong>Judy Campisi, PhD</strong>, spearheaded research on aging, cancer, and senescence. Dr. Campisi was a Professor of Biogerontology and Director of the Campisi Lab at theBuck Institute for Research on Aging, and ScientificCo-Founder or Unity Biotech, Campisi worked toward getting senolytic drugs into clinical trials with specific disease indications, such as osteoarthritis and glaucoma.</p><p>Dr. Campisi also co-authored research on removing senescent cells alleviates causes of diabetes in obese mice.</p> <div class="socials"> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="sidebar sidebar--big"> <div class="slider slider--embed slider--color color-blue"> <div class="slider__intro text-center"> <div class="shadow"></div> <h5>More from Dr. Campisi</h5> </div> <div class="slider__inner"> <div class="grid swiper-container js-slider-embed"> <div class="grid__inner swiper-wrapper slider__slides"> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/general/16900/Screen-Shot-2019-11-05-at-11.01.06-AM_f7a9bdabdac5f4ef029b9375b1a4069f.png" alt="Breakthroughs - Judy Campisi"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <h5 class="color-yellow">Watch<br /></h5><p>Dr. Campisi explains her research on senescence in this video, produced by the Buck Institute for Aging.</p> </div> <div class="swiper-pagination"></div> </div> <a href="http://www.youtube.com/watch?v=l0mFPoYNHOE" class="card__link component__link" target="_blank"></a> </div> </div> </div> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/general/243131/HumanCellsCloseUp_200123_175020_f7a9bdabdac5f4ef029b9375b1a4069f.jpg" alt="Human Cells Close Up"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <h5 class="color-yellow">Read</h5><p><em>Research in Aging Cell</em> co-authored by Dr. Campisi and six AFAR experts on targeting senescent cells alleviates obesity‐induced metabolic dysfunction.</p> </div> <div class="swiper-pagination"></div> </div> <a href="https://onlinelibrary.wiley.com/doi/full/10.1111/acel.12950" class="card__link component__link" target="_blank"></a> </div> </div> </div> </div> </div> <div class="slider-nav"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="jump-link-anchor" id="exercise"></div><div class="section section--padsm-top section--padsm-bottom section--bgclr color-blue section--bgimg"> <div class="section__bg section__bg--img poster inlay__bg--block-764192"></div> <style> .inlay__bg--block-764192 { background-image: url(/imager/sciencebackgroundphotos/244893/ExerciseShoe_b616f0dd1c9e12ac293f80067c1526ee.jpg); } @media (max-width: 1024px) { .inlay__bg--block-764192 { background-image: url(/imager/sciencebackgroundphotos/244893/ExerciseShoe_775dfc64901f4612608e87a7497e295b.jpg); } } @media (max-width: 480px) { .inlay__bg--block-764192 { background-image: url(/imager/sciencebackgroundphotos/244893/ExerciseShoe_4de3145e4a5f7b68a5e3a7333ae49011.jpg); } } </style> <div class="section__bg section__bg--clr"></div> <div class="section__inner section__pad"> <div class="shell"> <div class="grid grid--xs"> <div class="grid__inner"> <div class="grid-item grid-item--full"> <div class="component component--inherit "> <div class="inlay"> <div class="shadow"></div> <div class="inlay__bg inlay__bg--img component__bgimg poster inlay__bg--block-764192"></div> <div class="inlay__bg inlay__bg--clr component__bgclr"></div> <div class="inlay__inner"> <div class="article color-blue"> <div class="article__inner component__cols"> <div class="article__main" data-aos="fade-up"> <h2>Exercise has cellular and cognitive benefits<br /></h2><p>In addition to the established benefits of preserving cardiovascular health, reducing body fat, and lowering blood sugar, we now also know that exercise slows age-related processes within our cells, which can benefit the brain. <br /></p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="section section--bigbar section--padxs-top "> <div class="section__inner section__pad"> <div class="shell"> <div class="section__cols"> <div class="section__main"> <div class="component"> <div class="inlay"> <div class="inlay__inner"> <div class="article article--avatar article--avatarwrap color-blue"> <div class="article__inner component__cols"> <div class="article__main clear"> <div class="avatar avatar--alt"> <div class="avatar__inner"> <div class="avatar__image"> <img class="lazyload" data-src="/imager/granteeprofileimages/18262/Nathan-LeBrasseur-15423883_6fef9ec64b256ad6bee8afabc362a09e.jpg" alt="Nathan Le Brasseur"> </div> </div> </div> <div class="article__content" data-aos="fade-up"> <h4>Nathan LeBrasseur, PhD</h4><p>2002 <a href="https://www.afar.org/grants/glenn-postdoc">Glenn/AFAR Scholarship for Research in the Biology of Aging</a> and 2019 <a href="https://www.afar.org/vincent-cristofalo-award">Vincent Cristofalo Rising Star Award in Aging Research</a> recipient <strong>Nathan LeBrasseur, PhD</strong>, has found that exercise helps prevent diabetes-like symptoms by decreasing the effects of an unhealthy diet as well as levels of premature senescent cell accumulation. </p><p>Dr. LeBrasseur is an Associate Professor and Director of the Healthy Aging and Independent Living Program at the Kogod Aging Center at the Mayo Clinic.</p> <div class="socials"> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="sidebar sidebar--big"> <div class="slider slider--embed slider--color color-blue"> <div class="slider__intro text-center"> <div class="shadow"></div> <h5>More from Dr. LeBrasseur</h5> </div> <div class="slider__inner"> <div class="grid swiper-container js-slider-embed"> <div class="grid__inner swiper-wrapper slider__slides"> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/general/18477/Screen-Shot-2019-11-05-at-12.09.31-PM_f7a9bdabdac5f4ef029b9375b1a4069f.png" alt="Breakthroughs - LeBrasseur"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <h5 class="color-yellow">Watch </h5><p>Dr. LeBrasseur explains studies on impact of exercise on aging in mice in this Mayo Clinic clip.<br /></p> </div> <div class="swiper-pagination"></div> </div> <a href="https://www.youtube.com/watch?v=SRqmxfwf9aI" class="card__link component__link" target="_blank"></a> </div> </div> </div> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/sciencebackgroundphotos/244893/ExerciseShoe_f7a9bdabdac5f4ef029b9375b1a4069f.jpg" alt="Exercise Shoe"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <h5 class="color-yellow">Read<br /></h5><p>Research in <em>Diabetes</em> journal co-authored by Dr. LeBrasseur and other AFAR grantees on effect of exercise on diet-induced cellular senescence.</p> </div> <div class="swiper-pagination"></div> </div> <a href="https://www.ncbi.nlm.nih.gov/pubmed/26983960" class="card__link component__link" target="_blank"></a> </div> </div> </div> </div> </div> <div class="slider-nav"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="section section--bigbar section--padxs-top section--padxs-bottom"> <div class="section__inner section__pad"> <div class="shell"> <div class="section__cols"> <div class="section__main"> <div class="component"> <div class="inlay"> <div class="inlay__inner"> <div class="article article--avatar article--avatarwrap color-blue"> <div class="article__inner component__cols"> <div class="article__main clear"> <div class="avatar avatar--alt"> <div class="avatar__inner"> <div class="avatar__image"> <img class="lazyload" data-src="/imager/granteeprofileimages/19029/Ozioma-Okonkwo_6fef9ec64b256ad6bee8afabc362a09e.jpg" alt="Ozioma Okonkwo"> </div> </div> </div> <div class="article__content" data-aos="fade-up"> <h4>Ozioma Okonkwo, PhD<br /></h4><p>Research by 2013 <a href="https://www.afar.org/grants/beeson">Paul B. Beeson Emerging Leaders Career Development Award in Aging</a> Scholar <strong>Ozioma Okonkwo, PhD</strong>,<strong> </strong>has shown that exercise can help protect people against Alzheimer’s disease, even if they are at high genetic risk. His research has found that a moderate-intensity active lifestyle actually boosts cognitive function. Dr. Okonkwo is an Assistant Professor at the University of Wisconsin School of Medicine and Public Health.</p> <div class="socials"> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="sidebar sidebar--big"> <div class="slider slider--embed slider--color color-blue"> <div class="slider__intro text-center"> <div class="shadow"></div> <h5>More from Dr. Okonkwo</h5> </div> <div class="slider__inner"> <div class="grid "> <div class="grid__inner "> <div class="grid-item " style="width: 100%;""> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/general/248406/ExerciseGroup_Impact_f7a9bdabdac5f4ef029b9375b1a4069f.jpg" alt="Exercise Group Impact"> </div> <div class="card__inner"> <div class="card__content"> <h5 class="color-yellow">Read</h5><p><em>Washington Post</em> article highlighting Dr. Okonkwo’s research on Alzheimer’s and exercise.</p> </div> </div> <a href="https://www.washingtonpost.com/news/to-your-health/wp/2014/12/16/more-evidence-that-exercise-can-help-fight-alzheimers-disease/" class="card__link component__link" target="_blank"></a> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="section section--bigbar section--padxs-bottom"> <div class="section__inner section__pad"> <div class="shell"> <div class="section__cols"> <div class="section__main"> <div class="component"> <div class="inlay"> <div class="inlay__inner"> <div class="article article--avatar article--avatarwrap color-blue"> <div class="article__inner component__cols"> <div class="article__main clear"> <div class="avatar avatar--alt"> <div class="avatar__inner"> <div class="avatar__image"> <img class="lazyload" data-src="/imager/granteeprofileimages/19245/reisa-sperling-md_6fef9ec64b256ad6bee8afabc362a09e.jpg" alt="Reisa sperling md"> </div> </div> </div> <div class="article__content" data-aos="fade-up"> <h4>Reisa Sperling, MD</h4><p>2003 <a href="https://www.afar.org/grants/beeson">Paul B. Beeson Emerging Leaders Career Development Award in Aging</a> Scholar <strong>Reisa Sperling, MD</strong>, has spearheaded significant studies on the role of physical activity, walking in particular, in cognition and neurodegeneration in clinically normal older adults. </p><p>Dr. Sperling is the Director of the Center for Alzheimer’s Research and Treatment at the Massachusetts Alzheimer’s Disease Research Center, and a Professor of Neurology, Harvard Medical School.</p> <div class="socials"> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="sidebar sidebar--big"> <div class="slider slider--embed slider--color color-blue"> <div class="slider__intro text-center"> <div class="shadow"></div> <h5>More from Dr. Sperling</h5> </div> <div class="slider__inner"> <div class="grid swiper-container js-slider-embed"> <div class="grid__inner swiper-wrapper slider__slides"> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/scientistsinaction/63560/Reisa-Sperling_HarvardGazzette_f7a9bdabdac5f4ef029b9375b1a4069f.jpg" alt="Reisa Sperling Harvard Gazzette"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <h5 class="color-yellow">Read</h5><p>Research in JAMA Neurology co-authored by Dr. Sperling on physical activity, cognitive decline, and neurodegeneration.</p> </div> <div class="swiper-pagination"></div> </div> <a href="https://jamanetwork.com/journals/jamaneurology/article-abstract/2738357?resultClick=1" class="card__link component__link" target="_blank"></a> </div> </div> </div> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/general/60020/Annual-2018-Report_f7a9bdabdac5f4ef029b9375b1a4069f.png" alt="2018 Annual Report Image"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <h4 class="color-yellow">Big Questions, Breakthrough Science</h4><p>Read more about the impact of exercise on extending healthspan in AFAR’s 2018 Annual Report.</p> </div> <div class="swiper-pagination"></div> </div> <a href="https://www.afar.org/images/uploads/general/AFAR_2018_Annual_Report_forWeb.pdf" class="card__link component__link" target="_blank"></a> </div> </div> </div> </div> </div> <div class="slider-nav"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="jump-link-anchor" id="youngblood"></div><div class="section section--padsm-top section--padsm-bottom section--bgclr color-blue section--bgimg"> <div class="section__bg section__bg--img poster inlay__bg--block-764201"></div> <style> .inlay__bg--block-764201 { background-image: url(/imager/general/243395/RedBloodCells_b616f0dd1c9e12ac293f80067c1526ee.jpg); } @media (max-width: 1024px) { .inlay__bg--block-764201 { background-image: url(/imager/general/243395/RedBloodCells_775dfc64901f4612608e87a7497e295b.jpg); } } @media (max-width: 480px) { .inlay__bg--block-764201 { background-image: url(/imager/general/243395/RedBloodCells_4de3145e4a5f7b68a5e3a7333ae49011.jpg); } } </style> <div class="section__bg section__bg--clr"></div> <div class="section__inner section__pad"> <div class="shell"> <div class="grid grid--xs"> <div class="grid__inner"> <div class="grid-item grid-item--full"> <div class="component component--inherit "> <div class="inlay"> <div class="shadow"></div> <div class="inlay__bg inlay__bg--img component__bgimg poster inlay__bg--block-764201"></div> <div class="inlay__bg inlay__bg--clr component__bgclr"></div> <div class="inlay__inner"> <div class="article color-blue"> <div class="article__inner component__cols"> <div class="article__main" data-aos="fade-up"> <h2>Young blood has rejuvenating properties</h2><p>Blood of young animals contains molecules that can actually rejuvenate damaged heart, brain, and muscle in older adult animals. Although the identity of these molecules is still uncertain, researchers are curious to learn if humans have similar molecular rejuvenation patterns, which could help prevent or delay disorders like dementia and heart failure.</p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="section section--bigbar section--padxs-top "> <div class="section__inner section__pad"> <div class="shell"> <div class="section__cols"> <div class="section__main"> <div class="component"> <div class="inlay"> <div class="inlay__inner"> <div class="article article--avatar article--avatarwrap color-blue"> <div class="article__inner component__cols"> <div class="article__main clear"> <div class="avatar avatar--alt"> <div class="avatar__inner"> <div class="avatar__image"> <img class="lazyload" data-src="/imager/granteeprofileimages/17452/download_6fef9ec64b256ad6bee8afabc362a09e.jpeg" alt="Thomas Rando"> </div> </div> </div> <div class="article__content" data-aos="fade-up"> <h4>Thomas Rando MD, PhD<br /></h4><p>1990 <a href="https://www.afar.org/grants/beeson">Paul B. Beeson Emerging Leaders Career Development Award in Aging </a>and 2008 <a href="https://www.afar.org/grants/big">Glenn/AFAR Breakthroughs in Gerontology (BIG) Award</a> recipient and current AFAR <a href="https://www.afar.org/board-of-directors">Board Member</a> <strong>Thomas Rando, MD, PhD,</strong> of Stanford University was first in researching the role of young blood in reversing aging processes. </p><p>Dr. Rando’s research has explored what is in young blood that has this potential therapeutic benefit and also to try to understand what is actually changing in the old cells, at a molecular level, that makes them seem younger. </p><p>Dr. Rando is a Professor in the Department of Neurology and Neurological Sciences at Stanford University School of Medicine; Director of The Glenn Center for the Biology of Aging at Stanford University School of Medicine; and Deputy Director of the Stanford Center on Longevity (SCL). Dr. Rando is also an AFAR Board member.</p> <div class="socials"> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="sidebar sidebar--big"> <div class="slider slider--embed slider--color color-blue"> <div class="slider__intro text-center"> <div class="shadow"></div> <h5>More from Dr. Rando</h5> </div> <div class="slider__inner"> <div class="grid swiper-container js-slider-embed"> <div class="grid__inner swiper-wrapper slider__slides"> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/general/269488/Blood_TestTube_CellDetails_f7a9bdabdac5f4ef029b9375b1a4069f.jpg" alt="Blood Test Tube Cell Details"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <h5 class="color-yellow">Read</h5><p><em>New York Times </em>feature spotlighting Dr. Rando’s research with young blood's role in extending healthspan.</p> </div> <div class="swiper-pagination"></div> </div> <a href="https://www.nytimes.com/2014/05/05/science/young-blood-may-hold-key-to-reversing-aging.html" class="card__link component__link" target="_blank"></a> </div> </div> </div> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/scientistsinaction/63561/Tom-Rando-Lab_f7a9bdabdac5f4ef029b9375b1a4069f.jpg" alt="Tom Rando Lab"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <h5 class="color-yellow">Read</h5><p>Ask the Expert interview with Dr. Rando on young blood, biomarkers, and aging.</p> </div> <div class="swiper-pagination"></div> </div> <a href="https://www.afar.org/ask-the-expert/ask-the-expert-with-thomas-a-rando-md-phd" class="card__link component__link" target="_blank"></a> </div> </div> </div> </div> </div> <div class="slider-nav"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="jump-link-anchor" id="food"></div><div class="section section--padxs-top section--padxs-bottom section--bgclr color-blue section--bgimg"> <div class="section__bg section__bg--img poster inlay__bg--block-764205"></div> <style> .inlay__bg--block-764205 { background-image: url(/imager/general/21480/Plate_b616f0dd1c9e12ac293f80067c1526ee.jpg); } @media (max-width: 1024px) { .inlay__bg--block-764205 { background-image: url(/imager/general/21480/Plate_775dfc64901f4612608e87a7497e295b.jpg); } } @media (max-width: 480px) { .inlay__bg--block-764205 { background-image: url(/imager/general/21480/Plate_4de3145e4a5f7b68a5e3a7333ae49011.jpg); } } </style> <div class="section__bg section__bg--clr"></div> <div class="section__inner section__pad"> <div class="shell"> <div class="grid grid--xs"> <div class="grid__inner"> <div class="grid-item grid-item--full"> <div class="component component--inherit "> <div class="inlay"> <div class="shadow"></div> <div class="inlay__bg inlay__bg--img component__bgimg poster inlay__bg--block-764205"></div> <div class="inlay__bg inlay__bg--clr component__bgclr"></div> <div class="inlay__inner"> <div class="article color-blue"> <div class="article__inner component__cols"> <div class="article__main" data-aos="fade-up"> <h2>Restricting certain foods - without restricting calories - can increase healthspan<br /></h2><p>Research shows that the restriction of certain food components, such as protein, or even just foods containing a certain amino acid, methionine, may preserve health without restricting calories themselves. Recently new approaches to dietary restriction display both promise and practicality. Dietary timing in coordination with our biological or circadian clocks may extend health. <br /></p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="section section--bigbar section--padxs-top "> <div class="section__inner section__pad"> <div class="shell"> <div class="section__cols"> <div class="section__main"> <div class="component"> <div class="inlay"> <div class="inlay__inner"> <div class="article article--avatar article--avatarwrap color-blue"> <div class="article__inner component__cols"> <div class="article__main clear"> <div class="avatar avatar--alt"> <div class="avatar__inner"> <div class="avatar__image"> <img class="lazyload" data-src="/imager/granteeprofileimages/21453/valter-longo-en_6fef9ec64b256ad6bee8afabc362a09e.jpg" alt="Valter longo en"> </div> </div> </div> <div class="article__content" data-aos="fade-up"> <h4><strong>Valter D. Longo, PhD</strong></h4><p>1998 <a href="https://www.afar.org/grants/mcknight-award">AFAR Research Grant for Junior Faculty</a> and 2013 V<a href="https://www.afar.org/vincent-cristofalo-award">incent Cristofalo Rising Star Award in Aging Research</a> recipient <strong>Valter D. Longo, PhD,</strong> has pioneered research on a “fasting-mimicking diet” that includes periodically reducing caloric intake for five days. </p><p>His studies have shown that a diet that imitates fasting by periodically reducing calories decreases risk factors for age-related diseases such as heart disease and cancer, among others. </p><p>Dr. Longo is the Director of the USC Longevity Institute, Edna M.Jones Professor of Gerontology, and a Professor of Biological Sciences at the USC Leonard Davis School of Gerontology. He is the author of the book, The Longevity Diet.<br /></p> <div class="socials"> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="sidebar sidebar--big"> <div class="slider slider--embed slider--color color-blue"> <div class="slider__intro text-center"> <div class="shadow"></div> <h5>More from Dr. Longo</h5> </div> <div class="slider__inner"> <div class="grid swiper-container js-slider-embed"> <div class="grid__inner swiper-wrapper slider__slides"> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/general/21480/Plate_f7a9bdabdac5f4ef029b9375b1a4069f.jpg" alt="Breakthroughs - Plate"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <h5 class="color-yellow">Watch</h5><p>Dr. Longo's TED Talk, Fasting: Awakening the Rejuvenation from Within.</p> </div> <div class="swiper-pagination"></div> </div> <a href="https://www.youtube.com/watch?v=dVArDzYynYc" class="card__link component__link" target="_blank"></a> </div> </div> </div> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/general/22043/Screen-Shot-2019-11-05-at-2.17.35-PM_f7a9bdabdac5f4ef029b9375b1a4069f.png" alt="Breakthroughs - Longo Fasting"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <h5 class="color-yellow">Watch</h5><p><em>BBC News</em> segment spotlighting Dr. Longo</p> </div> <div class="swiper-pagination"></div> </div> <a href="https://www.bbc.com/news/magazine-21125016" class="card__link component__link" target="_blank"></a> </div> </div> </div> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/general/271318/Longo-Book_f7a9bdabdac5f4ef029b9375b1a4069f.jpg" alt="Longo Book"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <h5 class="color-yellow">Read</h5><p>Dr. Longo's book, The Longevity Diet.</p> </div> <div class="swiper-pagination"></div> </div> <a href="https://www.penguinrandomhouse.com/books/564866/the-longevity-diet-by-valter-longo-phd/" class="card__link component__link" target="_blank"></a> </div> </div> </div> </div> </div> <div class="slider-nav"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="section section--bigbar section--padxs-top section--padxs-bottom"> <div class="section__inner section__pad"> <div class="shell"> <div class="section__cols"> <div class="section__main"> <div class="component"> <div class="inlay"> <div class="inlay__inner"> <div class="article article--avatar article--avatarwrap color-blue"> <div class="article__inner component__cols"> <div class="article__main clear"> <div class="avatar avatar--alt"> <div class="avatar__inner"> <div class="avatar__image"> <img class="lazyload" data-src="/imager/granteeprofileimages/22557/Satchidananda-Panda_6fef9ec64b256ad6bee8afabc362a09e.jpg" alt="Satchidananda Panda"> </div> </div> </div> <div class="article__content" data-aos="fade-up"> <h4>Satchidananda Panda, PhD</h4><p>2014 Julie Martin Mid-Career Award in Aging Research recipient <strong>Satchidananda Panda, PhD</strong>, is a leader in research on the health benefits of aligning our eating patterns with the natural circadian rhythms programmed into our DNA. That means limiting food intake to eight to 12 hours a day, and fasting the rest of the time. </p><p>His research with mice shows that adhering to time-restricted eating reduced fat mass, reduced inflammation, reversed type 2 diabetes and fatty liver disease, and increased endurance—even when mice ate an unhealthy diet high in fat and sugar. <br /></p><p>Dr. Panda is a Professor at the Salk Institute for Biological Studies, where he leads the Panda Lab.</p><p>He is the author of the book, The Circadian Code.</p> <div class="socials"> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="sidebar sidebar--big"> <div class="slider slider--embed slider--color color-blue"> <div class="slider__intro text-center"> <div class="shadow"></div> <h5>More from Dr. Panda</h5> </div> <div class="slider__inner"> <div class="grid swiper-container js-slider-embed"> <div class="grid__inner swiper-wrapper slider__slides"> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/general/262555/Satchin-Ted-Talk_f7a9bdabdac5f4ef029b9375b1a4069f.png" alt="Satchin Ted Talk"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <h5 class="color-yellow">Watch</h5><p>Dr. Panda's TED Talk, Health lies in healthy circadian habits.</p> </div> <div class="swiper-pagination"></div> </div> <a href="https://www.youtube.com/watch?v=erBJuxVR7IE" class="card__link component__link" target=""></a> </div> </div> </div> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/general/24069/Screen-Shot-2019-11-05-at-5.58.08-PM_f7a9bdabdac5f4ef029b9375b1a4069f.png" alt="Breakthroughs - Panda Fasting"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <h5 class="color-yellow">Watch</h5><p>AFAR Webinar with Dr. Panda and Dr. Longo, It’s Not What You Eat, but When.</p> </div> <div class="swiper-pagination"></div> </div> <a href="https://www.youtube.com/watch?v=2a8TdvisQ9c&feature=youtu.be" class="card__link component__link" target=""></a> </div> </div> </div> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/general/271518/Panda-Book_f7a9bdabdac5f4ef029b9375b1a4069f.jpg" alt="Panda Book"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <h5 class="color-yellow">Read</h5><p>Dr. Panda's Book, The Circadian Code.</p> </div> <div class="swiper-pagination"></div> </div> <a href="https://www.penguinrandomhouse.com/books/592260/the-circadian-code-by-satchin-panda-phd/" class="card__link component__link" target=""></a> </div> </div> </div> </div> </div> <div class="slider-nav"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="jump-link-anchor" id="protein"></div><div class="section section--padsm-top section--padsm-bottom section--bgclr color-blue section--bgimg"> <div class="section__bg section__bg--img poster inlay__bg--block-764214"></div> <style> .inlay__bg--block-764214 { background-image: url(/imager/general/246386/Proteincelll-2_b616f0dd1c9e12ac293f80067c1526ee.jpg); } @media (max-width: 1024px) { .inlay__bg--block-764214 { background-image: url(/imager/general/246386/Proteincelll-2_775dfc64901f4612608e87a7497e295b.jpg); } } @media (max-width: 480px) { .inlay__bg--block-764214 { background-image: url(/imager/general/246386/Proteincelll-2_4de3145e4a5f7b68a5e3a7333ae49011.jpg); } } </style> <div class="section__bg section__bg--clr"></div> <div class="section__inner section__pad"> <div class="shell"> <div class="grid grid--xs"> <div class="grid__inner"> <div class="grid-item grid-item--full"> <div class="component component--inherit "> <div class="inlay"> <div class="shadow"></div> <div class="inlay__bg inlay__bg--img component__bgimg poster inlay__bg--block-764214"></div> <div class="inlay__bg inlay__bg--clr component__bgclr"></div> <div class="inlay__inner"> <div class="article color-blue"> <div class="article__inner component__cols"> <div class="article__main" data-aos="fade-up"> <h2>Preventing protein aggregation can preserve health<br /></h2><p>Aggregation of misfolded proteins has long been assumed to be involved in neurological diseases such as Alzheimer’s disease, where these aggregates form the classic plaques and tangles. We now know that preventing such protein aggregation misfolding preserves health generally.</p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="section section--bigbar section--padxs-top "> <div class="section__inner section__pad"> <div class="shell"> <div class="section__cols"> <div class="section__main"> <div class="component"> <div class="inlay"> <div class="inlay__inner"> <div class="article article--avatar article--avatarwrap color-blue"> <div class="article__inner component__cols"> <div class="article__main clear"> <div class="avatar avatar--alt"> <div class="avatar__inner"> <div class="avatar__image"> <img class="lazyload" data-src="/imager/granteeprofileimages/24789/anamaria-cuervo_6fef9ec64b256ad6bee8afabc362a09e.jpg" alt="Anamaria Cuervo"> </div> </div> </div> <div class="article__content" data-aos="fade-up"> <h4>Ana Maria Cuervo, MD, PhD</h4><p>2000 <a href="https://www.afar.org/grants/mcknight-award">AFAR Research Grant for Junior Faculty</a> recipient <strong>Ana Maria Cuervo, MD, PhD</strong>, is leader in the study of protein aggregation as it relates to the biology of aging, with an emphasis on neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s. </p><p>Dr. Cuervo is largely recognized in the field for her research in autophagy, a process cells use to dispose of or recycle their waste products, including damaged proteins and organelles, and the contribution of autophagy failure to aging and age-related diseases. </p><p>She is a Professor in Developmental and Molecular Biology, Anatomy and Structural Biology, and Medicine and co-director of the Institute for Aging Studies at the Albert Einstein College of Medicine.</p> <div class="socials"> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="sidebar sidebar--big"> <div class="slider slider--embed slider--color color-blue"> <div class="slider__intro text-center"> <div class="shadow"></div> <h5>More from Dr. Cuervo</h5> </div> <div class="slider__inner"> <div class="grid swiper-container js-slider-embed"> <div class="grid__inner swiper-wrapper slider__slides"> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/general/243661/Proteincelll_f7a9bdabdac5f4ef029b9375b1a4069f.jpg" alt="Proteincelll"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <h5 class="color-yellow">Read<br /></h5><p>Research in Cell co-authored by Dr. Cuervo on drug development to reinvigorate autophagy and combat Alzheimer's disease </p> </div> <div class="swiper-pagination"></div> </div> <a href="https://www.cell.com/cell/fulltext/S0092-8674(21)00379-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867421003792%3Fshowall%3Dtrue" class="card__link component__link" target="_blank"></a> </div> </div> </div> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/scientistsinaction/265656/CuervoLab_1_f7a9bdabdac5f4ef029b9375b1a4069f.jpeg" alt="Cuervo Lab 1"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <h5 class="color-yellow">Watch<br /></h5><p>Interview with Dr. Cuervo on Autophagy, courtesy of Albert Einstein College of Medicine.</p> </div> <div class="swiper-pagination"></div> </div> <a href="https://www.eurekalert.org/multimedia/pub/21556.php" class="card__link component__link" target=""></a> </div> </div> </div> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/general/262662/Autophagy_HEADER_f7a9bdabdac5f4ef029b9375b1a4069f.jpg" alt="Autophagy HEADER"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <h5 class="color-yellow">Watch</h5><p>Webinar with Dr. Cuervo on Selective Autophagy and Aging.<br /></p> </div> <div class="swiper-pagination"></div> </div> <a href="http://cost-proteostasis.eu/blog/event/selective-autophagy-in-the-fight-against-aging-and-age-related-disorders" class="card__link component__link" target="_blank"></a> </div> </div> </div> </div> </div> <div class="slider-nav"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="section section--bigbar section--padxs-top section--padxs-bottom"> <div class="section__inner section__pad"> <div class="shell"> <div class="section__cols"> <div class="section__main"> <div class="component"> <div class="inlay"> <div class="inlay__inner"> <div class="article article--avatar article--avatarwrap color-blue"> <div class="article__inner component__cols"> <div class="article__main clear"> <div class="avatar avatar--alt"> <div class="avatar__inner"> <div class="avatar__image"> <img class="lazyload" data-src="/imager/granteeprofileimages/25079/Andrew-Dillin_6fef9ec64b256ad6bee8afabc362a09e.jpg" alt="Andrew Dillin"> </div> </div> </div> <div class="article__content" data-aos="fade-up"> <h4>Andrew Dillin, PhD</h4><p>2010 AFAR <a href="https://www.afar.org/vincent-cristofalo-award">Vincent Cristofalo Rising Star Award in Aging Research </a>recipient <strong>Andrew Dillin, PhD</strong>, has advanced research on protein misfolding. His lab is particularly interested in understanding why an organism begins to lose control over the quality and integrity of its proteins as it ages, and how the recognition of protein misfolding stress is communicated to distal tissues and organs. </p><p>Dr. Dillin’s research has also explored correcting heat shock, a major cause of protein unraveling, by increasing the number of chaperone genes in the cell with the protein, HSF-1(heat shock factor-1). <br /></p><p>He is is a Howard Hughes Medical Investigator and the Thomas and Stacey Siebel Distinguished Chair in Stem Cell Research at the Department of Molecular and Cell Biology at Berkeley.</p><p> </p> <div class="socials"> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="sidebar sidebar--big"> <div class="slider slider--embed slider--color color-blue"> <div class="slider__intro text-center"> <div class="shadow"></div> <h5>More</h5> </div> <div class="slider__inner"> <div class="grid "> <div class="grid__inner "> <div class="grid-item " style="width: 100%;""> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/general/262663/Proteins_f7a9bdabdac5f4ef029b9375b1a4069f.jpg" alt="Proteins"> </div> <div class="card__inner"> <div class="card__content"> <h5 class="color-yellow">Read</h5><p>Article authored by Dr. Dillin on Ribosomal Perspective on Proteostasis and Aging in<em> Cell Metabolism’s </em>recent special issue on Aging.</p><p> </p> </div> </div> <a href="https://www.ncbi.nlm.nih.gov/pubmed/27304502" class="card__link component__link" target="_blank"></a> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="jump-link-anchor" id="drugs"></div><div class="section section--padxs-top section--padxs-bottom section--bgclr color-blue section--bgimg"> <div class="section__bg section__bg--img poster inlay__bg--block-764221"></div> <style> .inlay__bg--block-764221 { background-image: url(/imager/sciencebackgroundphotos/244278/FingerPillTightCrop_b616f0dd1c9e12ac293f80067c1526ee.jpg); } @media (max-width: 1024px) { .inlay__bg--block-764221 { background-image: url(/imager/sciencebackgroundphotos/244278/FingerPillTightCrop_775dfc64901f4612608e87a7497e295b.jpg); } } @media (max-width: 480px) { .inlay__bg--block-764221 { background-image: url(/imager/sciencebackgroundphotos/244278/FingerPillTightCrop_4de3145e4a5f7b68a5e3a7333ae49011.jpg); } } </style> <div class="section__bg section__bg--clr"></div> <div class="section__inner section__pad"> <div class="shell"> <div class="grid grid--xs"> <div class="grid__inner"> <div class="grid-item grid-item--full"> <div class="component component--inherit "> <div class="inlay"> <div class="shadow"></div> <div class="inlay__bg inlay__bg--img component__bgimg poster inlay__bg--block-764221"></div> <div class="inlay__bg inlay__bg--clr component__bgclr"></div> <div class="inlay__inner"> <div class="article color-blue"> <div class="article__inner component__cols"> <div class="article__main" data-aos="fade-up"> <h2>Drugs have been discovered that extend life in mice. One of these drugs, rapamycin, has remarkable age-related effects already.</h2><p>Since aging processes in mice and humans are similar, this suggests that these drugs may be formulated to prevent or alleviate multiple chronic diseases in humans. </p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="section section--bigbar section--padxs-top section--padxs-bottom"> <div class="section__inner section__pad"> <div class="shell"> <div class="section__cols"> <div class="section__main"> <div class="component"> <div class="inlay"> <div class="inlay__inner"> <div class="article article--avatar article--avatarwrap color-blue"> <div class="article__inner component__cols"> <div class="article__main clear"> <div class="avatar avatar--alt"> <div class="avatar__inner"> <div class="avatar__image"> <img class="lazyload" data-src="/imager/granteeprofileimages/25898/Nir-Barzilai_6fef9ec64b256ad6bee8afabc362a09e.jpg" alt="Nir Barzilai"> </div> </div> </div> <div class="article__content" data-aos="fade-up"> <h4><strong>Nir Barzilai, MD</strong></h4><p>AFAR <a href="https://www.afar.org/board-of-directors">Board Member</a> and multiple grantee <strong>Nir Barzilai, MD,</strong> is leading the <a href="https://www.afar.org/tame-trial">TAME Trial (Targeting Aging with Metformin) Trial</a>, which will test whether metformin—a drug currently prescribed as the first line of defense against type 2 (adult onset) diabetes and already taken by millions of people—can delay the onset of age-related diseases. </p><p>Through AFAR’s management, TAME is now in its planning stages and will open the door to more trials based on other promising drugs. </p><p>Dr. Barzilai is the Director of the Institute for Aging Research at the Albert Einstein College of Medicine and the Director of the Paul F. Glenn Center for the Biology of Human Aging Research and of the National Institutes of Health’s (NIH) Nathan Shock Centers of Excellence in the Basic Biology of Aging.</p><p><strong><br /></strong></p> <div class="socials"> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="sidebar sidebar--big"> <div class="slider slider--embed slider--color color-blue"> <div class="slider__intro text-center"> <div class="shadow"></div> <h5>More from Dr. Barzilai</h5> </div> <div class="slider__inner"> <div class="grid swiper-container js-slider-embed"> <div class="grid__inner swiper-wrapper slider__slides"> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/general/25939/Screen-Shot-2019-11-05-at-7.32.33-PM_f7a9bdabdac5f4ef029b9375b1a4069f.png" alt="Breakthroughs - Barziali"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <h5 class="color-yellow">Watch </h5><p>Dr. Barzilai’s TEDx Boston talk, Emerging Aging Research</p> </div> <div class="swiper-pagination"></div> </div> <a href="https://youtu.be/PbGA5-xG_6M" class="card__link component__link" target="_blank"></a> </div> </div> </div> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/general/687517/News-Item-Logo-Template-STAT_f7a9bdabdac5f4ef029b9375b1a4069f.jpg" alt="News Item Logo Template STAT"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <h5 class="color-yellow">Read</h5><p>Dr. Barzilai emphasizes the importance of funding the AFAR-managed TAME Trial to achieve an indication for aging from the Federal Food and Drug Administration (FDA) in STAT News.</p> </div> <div class="swiper-pagination"></div> </div> </div> </div> </div> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/general/215322/TAME_NirBarzilai-copy_f7a9bdabdac5f4ef029b9375b1a4069f.jpg" alt="TAME Nir Barzilai copy"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <h5 class="color-yellow">Read</h5><p><em>Wall Street Journal </em>cover story on the TAME Trial, Scientists’ New Goal: Growing Old Without Disease.</p> </div> <div class="swiper-pagination"></div> </div> <a href="https://www.wsj.com/articles/scientists-new-goal-growing-old-without-disease-1426542180" class="card__link component__link" target="_blank"></a> </div> </div> </div> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/general/265447/NEW_BRKTHRGH_KEY-ART-copy_f7a9bdabdac5f4ef029b9375b1a4069f.jpg" alt="NEW BRKTHRGH KEY ART copy"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <h5 class="color-yellow">Watch</h5><p>Dr. Barzilai and AFAR experts plan the TAME trial in <em>Breakthrough - The Age of Aging,</em> directed by Ron Howard on the National Geographic channel.</p> </div> <div class="swiper-pagination"></div> </div> <a href="https://www.youtube.com/playlist?list=PLhd0Aio5RRNL17_Y18tmoqa2N1CqoqJ5V" class="card__link component__link" target="_blank"></a> </div> </div> </div> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/general/476312/News-Item-Logo-_Vogue_f7a9bdabdac5f4ef029b9375b1a4069f.jpg" alt="News Item Logo Vogue"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <p><strong>Read</strong></p><p>Dr. Barzilai discusses ways to increase healthspan and the potential of metformin in <em>Vogue</em> feature, "<strong>Is Aging a Disease You Can</strong><strong> Reverse? A Look at the Science Behind the Longevity Movement</strong>"</p> </div> <div class="swiper-pagination"></div> </div> <a href="https://www.vogue.com/article/how-to-live-longer-longevity" class="card__link component__link" target="_blank"></a> </div> </div> </div> </div> </div> <div class="slider-nav"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="section section--bigbar "> <div class="section__inner section__pad"> <div class="shell"> <div class="section__cols"> <div class="section__main"> <div class="component"> <div class="inlay"> <div class="inlay__inner"> <div class="article article--avatar article--avatarwrap color-blue"> <div class="article__inner component__cols"> <div class="article__main clear"> <div class="avatar avatar--alt"> <div class="avatar__inner"> <div class="avatar__image"> <img class="lazyload" data-src="/imager/granteeprofileimages/25307/Matt-Kaeberlein_6fef9ec64b256ad6bee8afabc362a09e.jpg" alt="Matt Kaeberlein"> </div> </div> </div> <div class="article__content" data-aos="fade-up"> <h4>Matt Kaeberlein, PhD</h4><p>2006 <a href="https://www.afar.org/research/funding/afar-research-grants/">Glenn Foundation for Medical Research and AFAR Grants for Junior Faculty</a> recipient, and a 2007 <a href="https://www.afar.org/research/funding/big/">Glenn Foundation for Medical Research Breakthroughs in Gerontology (BIG) Award</a> recipient<strong> Matt Kaeberlein, PhD, is spearheading the innovative Dog Aging Project, </strong>which explores how rapamycin can help extend health in canines and in doing so, help us better understand human aging.</p><p>In mice, the drug rapamycin has been shown to delay the onset of Alzheimer’s disease and even slow normal age-related memory decline, preserve heart function, prevent several types of cancer, and improve vaccine response in older adults. </p><p>Dr. Kaeberlein is a Professor in the Department of Pathology, University of Washington, Seattle; Director of the <a href="http://www.uwhealthyaging.org/">University of Washington Healthy Aging and Longevity Research Institute</a>; and Co-Director of the <a href="http://nathanshockcenters.org/university-of-washington">University of Washington Medicine Nathan Shock Center of Excellence in the Basic Biology of Aging</a>.<br /><br /></p> <div class="socials"> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="sidebar sidebar--big"> <div class="slider slider--embed slider--color color-blue"> <div class="slider__intro text-center"> <div class="shadow"></div> <h5>More from Dr. Kaeberlein</h5> </div> <div class="slider__inner"> <div class="grid swiper-container js-slider-embed"> <div class="grid__inner swiper-wrapper slider__slides"> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/general/269389/DogAgingWebinarGraphic-2-copy_f7a9bdabdac5f4ef029b9375b1a4069f.jpg" alt="Dog Aging Webinar Graphic 2 copy"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <h5 class="color-yellow">Watch</h5><p>Webinar with Dr. Kaeberlein, The Dog Aging Project: Learning from Man’s Best Friend.</p> </div> <div class="swiper-pagination"></div> </div> <a href="https://www.youtube.com/watch?v=2QmT2qhkrx8" class="card__link component__link" target="_blank"></a> </div> </div> </div> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/general/13989/MIT-TECH-REVIEW_f7a9bdabdac5f4ef029b9375b1a4069f.png" alt="MIT Review Logo"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <p><strong>Read</strong></p><p>Dr. Kaeberlein discusses how the Dog Aging Project is helping advance the field's understanding of therapeutics that target the biological processes of aging to extend healthspan.</p> </div> <div class="swiper-pagination"></div> </div> </div> </div> </div> </div> </div> <div class="slider-nav"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="section section--bigbar section--padxs-top section--padxs-bottom"> <div class="section__inner section__pad"> <div class="shell"> <div class="section__cols"> <div class="section__main"> <div class="component"> <div class="inlay"> <div class="inlay__inner"> <div class="article article--avatar article--avatarwrap color-blue"> <div class="article__inner component__cols"> <div class="article__main clear"> <div class="avatar avatar--alt"> <div class="avatar__inner"> <div class="avatar__image"> <img class="lazyload" data-src="/imager/granteeprofileimages/25196/Daniel-Promislow_6fef9ec64b256ad6bee8afabc362a09e.jpg" alt="Daniel Promislow"> </div> </div> </div> <div class="article__content" data-aos="fade-up"> <h4>Daniel Promislow, PhD</h4><p>1996 <a href="https://www.afar.org/grants/mcknight-award">AFAR Research Grants for Junior Faculty</a> recipient <strong>Daniel Promislow, PhD,</strong> also is leading the Dog Aging Project exploring rapamycin’s extension of healthspan. </p><p>The project may thereby help identify risk factors that influence human life span. Since dogs age significantly more rapidly than humans, data on aging can be generated much more rapidly using a dog model than in human studies.</p><p>At the University of Washington, Dr. Promislow is a Professor in the Department of Pathology and Department of Biology. He is also the Director of the Canine Longevity Consortium. </p> <div class="socials"> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="sidebar sidebar--big"> <div class="slider slider--embed slider--color color-blue"> <div class="slider__intro text-center"> <div class="shadow"></div> <h5>More from Dr. Promislow</h5> </div> <div class="slider__inner"> <div class="grid swiper-container js-slider-embed"> <div class="grid__inner swiper-wrapper slider__slides"> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/general/263298/Rabinovich-Dog_f7a9bdabdac5f4ef029b9375b1a4069f.jpg" alt="Rabinovich Dog"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <h5 class="color-yellow">Read</h5><p><em>New York Times</em> cover story on the Dog Aging Project, Dogs Test Drug Aimed at Humans’ Biggest Killer: Age.</p> </div> <div class="swiper-pagination"></div> </div> <a href="https://www.nytimes.com/2016/05/17/us/aging-research-disease-dogs.html?emc=edit_tnt_20160516&nlid=46939967&tntemail0=y&_r=0" class="card__link component__link" target="_blank"></a> </div> </div> </div> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/general/25421/adult-golden-retriever-close-up-photography-1490908_f7a9bdabdac5f4ef029b9375b1a4069f.jpg" alt="Adult golden retriever close up photography 1490908"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <h4 class="color-yellow">Furrever Young</h4><p>Recent feature on Medium spotlighting the Dog Aging Project’s early findings and potential impact.</p> </div> <div class="swiper-pagination"></div> </div> <a href="https://gen.medium.com/furrever-young-dog-canine-research-aging-dfaa5a31511c" class="card__link component__link" target="_blank"></a> </div> </div> </div> </div> </div> <div class="slider-nav"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="section section--bigbar section--padxs-bottom"> <div class="section__inner section__pad"> <div class="shell"> <div class="section__cols"> <div class="section__main"> <div class="component"> <div class="inlay"> <div class="inlay__inner"> <div class="article article--avatar article--avatarwrap color-blue"> <div class="article__inner component__cols"> <div class="article__main clear"> <div class="avatar avatar--alt"> <div class="avatar__inner"> <div class="avatar__image"> <img class="lazyload" data-src="/imager/afargranteeseventimages/262988/peter-rabinovitch_f7f7a8065fc3d124ad8064c433521dac.jpg" alt="Peter rabinovitch"> </div> </div> </div> <div class="article__content" data-aos="fade-up"> <h4>Peter Rabinovich,MD, PhD</h4><p>Research led by 2010 <a href="https://www.afar.org/grants/big">Glen Foundation for Medical Research Breakthroughs in Gerontology (BIG) Award</a> recipient <strong>Peter S. Rabinovitch, MD, PhD</strong> has found that the drug Elamipretide (SS-31) may boost function of mitochondria, the powerhouse of cells. There have been clear and immediate benefits shown in old mice on heart and muscle, brain and kidney injury, type II diabetes, glaucoma, and is being evaluated in Alzheimer’s disease. </p><p>Dr. Rabinovitch is a Professor and Vice Chair of Research, Director of the Flow Cytometry Laboratory at the University of Washington Medicine. Dr. Marcinek is a Associate Professor at UW Medicine and Principal Investigator of the Marcinek Lab.</p> <div class="socials"> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="sidebar sidebar--big"> <div class="slider slider--embed slider--color color-blue"> <div class="slider__intro text-center"> <div class="shadow"></div> <h5>More from Dr. Rabinovich</h5> </div> <div class="slider__inner"> <div class="grid "> <div class="grid__inner "> <div class="grid-item " style="width: 100%;""> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/general/262990/Mitochondria_f7a9bdabdac5f4ef029b9375b1a4069f.jpg" alt="Mitochondria"> </div> <div class="card__inner"> <div class="card__content"> <h4 class="color-yellow">Mitochondrial Protective Interventions, Aging and Healthspan</h4><p>Dr. Rabinovitch’s NIH funded research to test the hypothesis that mitochondrial targeted therapeutics are capable of resisting age-related disease and improving health and function in aging mammals.</p> </div> </div> <a href="http://grantome.com/grant/NIH/P01-AG001751-33A1" class="card__link component__link" target="_blank"></a> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="section section--bigbar section--padxs-top section--padxs-bottom"> <div class="section__inner section__pad"> <div class="shell"> <div class="section__cols"> <div class="section__main"> <div class="component"> <div class="inlay"> <div class="inlay__inner"> <div class="article article--avatar article--avatarwrap color-blue"> <div class="article__inner component__cols"> <div class="article__main clear"> <div class="avatar avatar--alt"> <div class="avatar__inner"> <div class="avatar__image"> <img class="lazyload" data-src="/imager/granteeprofileimages/27126/marcinek_6fef9ec64b256ad6bee8afabc362a09e.jpg" alt="Marcinek"> </div> </div> </div> <div class="article__content" data-aos="fade-up"> <h4>David J. Marcinek, PhD<br /><br /></h4><p>Along with Dr. Rabinovitch, 2015 <a href="https://www.afar.org/grants/big">BIG Award</a> winner <strong>David J. Marcineck, PhD</strong>, is pioneering research on mitochondrial redox biology as well as mitochondria and environmental health and toxin exposure.</p><p>Dr. Marcinek is a Associate Professor at UW Medicine.</p> <div class="socials"> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="sidebar sidebar--big"> <div class="slider slider--embed slider--color color-blue"> <div class="slider__intro text-center"> <div class="shadow"></div> <h5>More from Dr. Marcinek</h5> </div> <div class="slider__inner"> <div class="grid "> <div class="grid__inner "> <div class="grid-item " style="width: 100%;""> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/general/262991/Mitochondria_2_f7a9bdabdac5f4ef029b9375b1a4069f.jpg" alt="Mitochondria 2"> </div> <div class="card__inner"> <div class="card__content"> <h4 class="color-yellow">Guiding Ageing Research into Maturity</h4><p>Scientia feature on Dr. Marcinek’s SS-31 research.</p> </div> </div> <a href="https://www.scientia.global/dr-david-marcinek-guiding-ageing-research-maturity/" class="card__link component__link" target="_blank"></a> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="section section--bigbar section--padxs-bottom"> <div class="section__inner section__pad"> <div class="shell"> <div class="section__cols"> <div class="section__main"> <div class="component"> <div class="inlay"> <div class="inlay__inner"> <div class="article article--avatar article--avatarwrap color-blue"> <div class="article__inner component__cols"> <div class="article__main clear"> <div class="avatar avatar--alt"> <div class="avatar__inner"> <div class="avatar__image"> <img class="lazyload" data-src="/imager/granteeprofileimages/26942/David-Sinclair-500_6fef9ec64b256ad6bee8afabc362a09e.png" alt="David Sinclair"> </div> </div> </div> <div class="article__content" data-aos="fade-up"> <h4>David Sinclair, PhD, AO<br /></h4><p>2000 <a href="https://www.afar.org/grants/mcknight-award">AFAR Research Grant for Junior Faculty</a> and 2018 <a href="https://www.afar.org/irving-s-wright-award">Irving S. Wright Award</a> recipient <strong>David Sinclair, PhD, AO</strong>, has been instrumental in furthering understanding of how sirtuins are modulated by endogenous molecules and pharmacological agents such as resveratrol, a plant-derived molecule found in red wine in mice. There are seven types of sirtuins and each plays a role in the hallmarks or processes of aging. </p><p>As sirtuins are dependent on nicotinamide adenine dinucleotide (NAD), and NAD levels drop by half as we age, Dr. Sinclair is currently working on NAD-booster molecules to restore those NAD levels to youthful levels. </p><p>Dr. Sinclair is a Professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. </p><p>He is the author of the book, Lifespan: The Revolutionary Science of Why We Age -- and Why We Don't.</p> <div class="socials"> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="sidebar sidebar--big"> <div class="slider slider--embed slider--color color-blue"> <div class="slider__intro text-center"> <div class="shadow"></div> <h5>More from Dr. Sinclair</h5> </div> <div class="slider__inner"> <div class="grid swiper-container js-slider-embed"> <div class="grid__inner swiper-wrapper slider__slides"> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/general/26960/Screen-Shot-2019-11-05-at-7.58.30-PM_f7a9bdabdac5f4ef029b9375b1a4069f.png" alt="Breakthroughs - Sinclare"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <h5 class="color-yellow">Watch</h5><p>Lecture by Dr. Sinclair, Cracking & reversing the aging clock.</p> </div> <div class="swiper-pagination"></div> </div> <a href="www.youtube.com/watch?v=Eu0GksWf5pI" class="card__link component__link" target="_blank"></a> </div> </div> </div> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/scientistsinaction/263605/Sinclair-Lab_f7a9bdabdac5f4ef029b9375b1a4069f.jpg" alt="Sinclair Lab"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <h5 class="color-yellow">Read</h5><p><em>WIRED</em> op-ed by Dr. Sinclair and Dr. Barzilai, "This is Why We Need to Start Treating Ageing as We Treat Disease."<br /></p> </div> <div class="swiper-pagination"></div> </div> <a href="https://www.wired.co.uk/article/medicine-disease-ageing" class="card__link component__link" target="_blank"></a> </div> </div> </div> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/general/272514/Sinclair-Book_f7a9bdabdac5f4ef029b9375b1a4069f.jpg" alt="Sinclair Book"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <h5 class="color-yellow">Read</h5><p>Dr. Sinclair's book, Lifespan: The Revolutionary Science of Why We Age -- and Why We Don't.</p> </div> <div class="swiper-pagination"></div> </div> </div> </div> </div> </div> </div> <div class="slider-nav"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="jump-link-anchor" id="sexes"></div><div class="section section--padsm-top section--padsm-bottom section--bgclr color-blue section--bgimg"> <div class="section__bg section__bg--img poster inlay__bg--block-764242"></div> <style> .inlay__bg--block-764242 { background-image: url(/imager/general/246789/XX-Chromosome_b616f0dd1c9e12ac293f80067c1526ee.jpg); } @media (max-width: 1024px) { .inlay__bg--block-764242 { background-image: url(/imager/general/246789/XX-Chromosome_775dfc64901f4612608e87a7497e295b.jpg); } } @media (max-width: 480px) { .inlay__bg--block-764242 { background-image: url(/imager/general/246789/XX-Chromosome_4de3145e4a5f7b68a5e3a7333ae49011.jpg); } } </style> <div class="section__bg section__bg--clr"></div> <div class="section__inner section__pad"> <div class="shell"> <div class="grid grid--xs"> <div class="grid__inner"> <div class="grid-item grid-item--full"> <div class="component component--inherit "> <div class="inlay"> <div class="shadow"></div> <div class="inlay__bg inlay__bg--img component__bgimg poster inlay__bg--block-764242"></div> <div class="inlay__bg inlay__bg--clr component__bgclr"></div> <div class="inlay__inner"> <div class="article color-blue"> <div class="article__inner component__cols"> <div class="article__main" data-aos="fade-up"> <h2><strong><strong>Biological processes of aging may differ between sexes.</strong></strong></h2><p>Therapies that have proven successful at preserving health in mice are effective only in one sex: might human treatments to preserve health differ for men and women? Differences in longevity and healthspan between the sexes should be explored to help understand mechanisms underlying variation in longevity within a species.</p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="section section--bigbar section--padxs-top section--padxs-bottom"> <div class="section__inner section__pad"> <div class="shell"> <div class="section__cols"> <div class="section__main"> <div class="component"> <div class="inlay"> <div class="inlay__inner"> <div class="article article--avatar article--avatarwrap color-blue"> <div class="article__inner component__cols"> <div class="article__main clear"> <div class="avatar avatar--alt"> <div class="avatar__inner"> <div class="avatar__image"> <img class="lazyload" data-src="/imager/granteeprofileimages/28064/Steven_Austad_mix-1_6fef9ec64b256ad6bee8afabc362a09e.png" alt="Steven Austad"> </div> </div> </div> <div class="article__content" data-aos="fade-up"> <h4><strong>Steven N. Austad, PhD</strong></h4><p>AFAR <a href="https://www.afar.org/scientific-leadership">Senior Scientific Director</a> <strong>Steven N. Austad, PhD,</strong> is contributing to some of the most high-profile research on how the biology of aging may differ between men and women through the study. </p><p>Dr. Austad is a distinguished professor and Chair of the Department of Biology at the University of Alabama at Birmingham. In addition to be the Director of the Nathan Shock Center of Excellence in the Basic Biology of Aging at UAB, Dr. Austad is the co-Principal Investigator of the NSC Coordinating Center for the NIA.<br /></p> <div class="socials"> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="sidebar sidebar--big"> <div class="slider slider--embed slider--color color-blue"> <div class="slider__intro text-center"> <div class="shadow"></div> <h5>More from Dr. Austad</h5> </div> <div class="slider__inner"> <div class="grid swiper-container js-slider-embed"> <div class="grid__inner swiper-wrapper slider__slides"> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/scientistsinaction/267589/StevenAustadLab_CourestyUniversityofAlabamaBirmingham_f7a9bdabdac5f4ef029b9375b1a4069f.jpg" alt="Steven Austad Lab Couresty Universityof Alabama Birmingham"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <h5 class="color-yellow">Read<br /></h5><p>Research co-authored by Dr. Austad on Sex Differences in Lifespan in <em>Cell Metabolism's</em> special Aging issue.</p> </div> <div class="swiper-pagination"></div> </div> <a href="https://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30237-6" class="card__link component__link" target="_blank"></a> </div> </div> </div> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/general/263606/MultiGenerationalandMultiGender_f7a9bdabdac5f4ef029b9375b1a4069f.jpg" alt="Multi Generationaland Multi Gender"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <h5 class="color-yellow">Read</h5><p>Dr. Austad’s column for PBS Next Avenue on What Biology Tells Us About Gender and Longevity.</p> </div> <div class="swiper-pagination"></div> </div> <a href="https://www.nextavenue.org/biology-gender-longevity/" class="card__link component__link" target="_blank"></a> </div> </div> </div> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/general/263607/SexDiffCells_f7a9bdabdac5f4ef029b9375b1a4069f.jpg" alt="Sex Diff Cells"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <h5 class="color-yellow">Explore<br /></h5><p>In June 2019, The Research Centers Collaborative Network of the NIA hosted a two-day workshop on Sex and Gender Differences in Aging. Experts across biomedical and social sciences shared insights. Download their presentations here.<br /></p> </div> <div class="swiper-pagination"></div> </div> <a href="https://www.rccn-aging.org/sex-and-gender-rccn-workshop" class="card__link component__link" target="_blank"></a> </div> </div> </div> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/general/402264/guardian-logo-guardian-logo-white-background-vector-format-avaliable-148310066_f7a9bdabdac5f4ef029b9375b1a4069f.jpg" alt="Guardian logo guardian logo white background vector format avaliable 148310066"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <h5 class="color-yellow">Read</h5><p>Insights from Dr. Austad on sex chromosomes and longevity in <em>The Guardian</em> feature, "Mystery of lifespan gap between sexes may be solved, say researchers."</p> </div> <div class="swiper-pagination"></div> </div> <a href="https://www.theguardian.com/science/2020/mar/04/mystery-of-lifespan-gap-between-sexes-may-be-solved-say-researchers" class="card__link component__link" target="_blank"></a> </div> </div> </div> </div> </div> <div class="slider-nav"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="section section--bigbar "> <div class="section__inner section__pad"> <div class="shell"> <div class="section__cols"> <div class="section__main"> <div class="component"> <div class="inlay"> <div class="inlay__inner"> <div class="article article--avatar article--avatarwrap color-blue"> <div class="article__inner component__cols"> <div class="article__main clear"> <div class="avatar avatar--alt"> <div class="avatar__inner"> <div class="avatar__image"> <img class="lazyload" data-src="/imager/granteeprofileimages/28069/DubalD_6fef9ec64b256ad6bee8afabc362a09e.jpg" alt="Dena Dubal"> </div> </div> </div> <div class="article__content" data-aos="fade-up"> <h4><strong>Dena Dubal, MD, PhD</strong></h4><p>2015 <a href="https://www.afar.org/grants/mcknight-award">AFAR Research Grant for Junior Faculty</a>, 2009 <a href="https://www.afar.org/grants/beeson">Paul B. Beeson Emerging Leaders Career Development Award in Aging</a>, and 1998 <a href="https://www.afar.org/grants/afar-scholarships">AFAR Scholarships for Research in the Biology of Aging</a> recipient <strong>Dena Dubal, MD, PhD,</strong> is leading research on the X-chromosome and aging. </p><p>Dr. Dubal’s lab is determining how the second X chromosome confers neural resilience in aging and disease through mechanisms of escape from X inactivation-- and from parent-of-origin X imprinting. </p><p>She is have studied on mice how the pattern of ovarian cycle effects on disease-related networks, cognition, and pathogenic protein expression; translated to humans, this research may be relevant to young women at risk for Alzheimer’s disease.</p><p>Dr. Dubal is an Assistant Professor at the UCSF Memory and Aging Center.</p> <div class="socials"> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="sidebar sidebar--big"> <div class="slider slider--embed slider--color color-blue"> <div class="slider__intro text-center"> <div class="shadow"></div> <h5>More from Dr. Dubal</h5> </div> <div class="slider__inner"> <div class="grid swiper-container js-slider-embed"> <div class="grid__inner swiper-wrapper slider__slides"> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/general/246789/XX-Chromosome_f7a9bdabdac5f4ef029b9375b1a4069f.jpg" alt="XX Chromosome"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <h5 class="color-yellow">Read</h5><p>Research in <em>Aging Cell</em> authored by Dr. Dubal and AFAR grantee Emily Davis on XX sex chromosomes increasing survival and extend lifespan in aging mice.</p> </div> <div class="swiper-pagination"></div> </div> <a href="https://onlinelibrary.wiley.com/doi/full/10.1111/acel.12871" class="card__link component__link" target="_blank"></a> </div> </div> </div> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/scientistsinaction/63547/Dena-Dubal-lab_Courtesy-of-UCSF-1_14e12775995637ddecfec545a1442f84.jpg" alt="Dena Dubal lab Courtesy of UCSF 1"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <h5 class="color-yellow">Read</h5><h5 class="color-yellow">Dr. Dubal’s research on Ovarian Cycle Stages Modulate Alzheimer-Related Cognitive and Brain Net-work Alterations in Female Mice in the <em>Journal of Neuroscience.</em></h5> </div> <div class="swiper-pagination"></div> </div> <a href="https://www.eneuro.org/content/5/6/ENEURO.0132-17.2018" class="card__link component__link" target="_blank"></a> </div> </div> </div> </div> </div> <div class="slider-nav"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="section section--bigbar "> <div class="section__inner section__pad"> <div class="shell"> <div class="section__cols"> <div class="section__main"> <div class="component"> <div class="inlay"> <div class="inlay__inner"> <div class="article article--avatar article--avatarwrap color-blue"> <div class="article__inner component__cols"> <div class="article__main clear"> <div class="avatar avatar--alt"> <div class="avatar__inner"> <div class="avatar__image"> <img class="lazyload" data-src="/imager/granteeprofileimages/27665/Dudley-Lamming_6fef9ec64b256ad6bee8afabc362a09e.jpg" alt="Dudley Lamming"> </div> </div> </div> <div class="article__content" data-aos="fade-up"> <h4><strong>Dudley Lamming, PhD</strong></h4><p>2015 <a href="https://www.afar.org/grants/mcknight-award">AFAR Research Grant for Junior Faculty</a> recipient <strong>Dudley Lamming, PhD, </strong>is looking at sexual dimorphism in response to longevity interventions. </p><p>He has studied how a gene called “RICTOR” may be responsible for the differential effects of the drug rapamycin in males and females. The gene is involved in many bodily functions, including growth and development, as well as diseases such as diabetes and cancer. He is testing whether sex hormones, such as estrogen and testosterone, affect what RICTOR does in the liver, and whether these hormones are important regulators of mouse longevity. </p><p>Dr. Lamming is an assistant professor at the University of Wisconsin-Madison.</p> <div class="socials"> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="sidebar sidebar--big"> <div class="slider slider--embed slider--color color-blue"> <div class="slider__intro text-center"> <div class="shadow"></div> <h5>More from Dr. Lamming</h5> </div> <div class="slider__inner"> <div class="grid "> <div class="grid__inner "> <div class="grid-item " style="width: 100%;""> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/scientistsinaction/264218/Lamming-Dudley-RCT_3520_2018_02_07_med-copy_f7a9bdabdac5f4ef029b9375b1a4069f.jpg" alt="Lamming Dudley RCT 3520 2018 02 07 med copy"> </div> <div class="card__inner"> <div class="card__content"> <h5 class="color-yellow">Read</h5><p>Dr. Lamming’s research on Rictor and male lifespan in <em>Aging Cell.</em></p> </div> </div> <a href="https://www.ncbi.nlm.nih.gov/pubmed/25059582" class="card__link component__link" target="_blank"></a> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="jump-link-anchor" id="reprogramming"></div><div class="section section--padxs-top section--padxs-bottom section--bgclr color-blue section--bgimg"> <div class="section__bg section__bg--img poster inlay__bg--block-764253"></div> <style> .inlay__bg--block-764253 { background-image: url(/imager/general/599267/Reprorgramming_A_b616f0dd1c9e12ac293f80067c1526ee.jpg); } @media (max-width: 1024px) { .inlay__bg--block-764253 { background-image: url(/imager/general/599267/Reprorgramming_A_775dfc64901f4612608e87a7497e295b.jpg); } } @media (max-width: 480px) { .inlay__bg--block-764253 { background-image: url(/imager/general/599267/Reprorgramming_A_4de3145e4a5f7b68a5e3a7333ae49011.jpg); } } </style> <div class="section__bg section__bg--clr"></div> <div class="section__inner section__pad"> <div class="shell"> <div class="grid grid--xs"> <div class="grid__inner"> <div class="grid-item grid-item--full"> <div class="component component--inherit "> <div class="inlay"> <div class="shadow"></div> <div class="inlay__bg inlay__bg--img component__bgimg poster inlay__bg--block-764253"></div> <div class="inlay__bg inlay__bg--clr component__bgclr"></div> <div class="inlay__inner"> <div class="article color-blue"> <div class="article__inner component__cols"> <div class="article__main" data-aos="fade-up"> <h2>Cells can be reprogrammed to restore function.</h2><p>An exciting discovery is that by turning on a handful of genes, virtually any cell type in our body — liver cell, skin cell, lung cell, brain cell— can be reprogrammed in a dish to resemble the type of stem cell from which all of our cells originated during embryonic life. That reprogramming also may restore many aspects of youthful cell function. Recent studies in mice show that genes can be turned on and off at will, and that mice show rejuvenation of numerous bodily functions when the genes are turned on briefly. Muscles, metabolism, and even optic nerves of old mice have been restored to youthful function. The human implications, of course, are stunning.</p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="section section--bigbar section--padxs-top section--padxs-bottom"> <div class="section__inner section__pad"> <div class="shell"> <div class="section__cols"> <div class="section__main"> <div class="component"> <div class="inlay"> <div class="inlay__inner"> <div class="article article--avatar article--avatarwrap color-blue"> <div class="article__inner component__cols"> <div class="article__main clear"> <div class="avatar avatar--alt"> <div class="avatar__inner"> <div class="avatar__image"> <img class="lazyload" data-src="/imager/granteeprofileimages/26942/David-Sinclair-500_6fef9ec64b256ad6bee8afabc362a09e.png" alt="David Sinclair"> </div> </div> </div> <div class="article__content" data-aos="fade-up"> <h4><strong>David Sinclair, PhD, AO<br /></strong></h4><p>2000 <a href="https://www.afar.org/grants/mcknight-award">AFAR Research Grant for Junior Faculty</a>, 2018 <a href="https://www.afar.org/irving-s-wright-award">Irving S. Wright Award</a> recipient and AFAR board member <strong>David Sinclair, PhD, AO</strong>, has led significant research that asks if epigenetic changes are a driver of aging, can you reset the epigenome? </p><p><br />Dr. Sinclair is a Professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School.</p><p>He is the author of the book, Lifespan: The Revolutionary Science of Why We Age -- and Why We Don't.</p> <div class="socials"> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="sidebar sidebar--big"> <div class="slider slider--embed slider--color color-blue"> <div class="slider__intro text-center"> <div class="shadow"></div> <h5>More from Dr. Sinclair</h5> </div> <div class="slider__inner"> <div class="grid swiper-container js-slider-embed"> <div class="grid__inner swiper-wrapper slider__slides"> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/general/473640/News-Item-Logo-Template-TIME_f7a9bdabdac5f4ef029b9375b1a4069f.jpg" alt="News Item Logo Template TIME"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <p> TIME magazine spotlights Dr. Sinclair's recently published research in Cell on the epigemone, aging clock and slowing aging in mice.</p> </div> <div class="swiper-pagination"></div> </div> <a href="https://time.com/6246864/reverse-aging-scientists-discover-milestone/" class="card__link component__link" target="_blank"></a> </div> </div> </div> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/general/727558/News-Item-Logo-Template-NatureAging_230518_173730_f7a9bdabdac5f4ef029b9375b1a4069f.jpg" alt="News Item Logo Template Nature Aging"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <h5 class="color-yellow">Listen</h5><p>Research co-authored in Nature by Dr. Sinclair on reversal of biological clock restores vision in old mice.</p> </div> <div class="swiper-pagination"></div> </div> <a href="https://www.nature.com/articles/d41586-020-03403-0" class="card__link component__link" target="_blank"></a> </div> </div> </div> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/general/600883/TheDrive-Attia_f7a9bdabdac5f4ef029b9375b1a4069f.jpg" alt="The Drive Attia"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <p>Dr. Sinclair discusses cellular programming in the podcast, The Drive, with Peter Attia, MD.</p> </div> <div class="swiper-pagination"></div> </div> <a href="https://podcasts.apple.com/au/podcast/david-sinclair-ph-d-how-cellular-reprogramming-could/id1400828889?i=1000449096131" class="card__link component__link" target="_blank"></a> </div> </div> </div> </div> </div> <div class="slider-nav"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="jump-link-anchor" id="biomarkers"></div><div class="section section--padxs-top section--padxs-bottom section--bgclr color-blue section--bgimg"> <div class="section__bg section__bg--img poster inlay__bg--block-764258"></div> <style> .inlay__bg--block-764258 { background-image: url(/imager/general/599276/BioMarkers_b616f0dd1c9e12ac293f80067c1526ee.jpg); } @media (max-width: 1024px) { .inlay__bg--block-764258 { background-image: url(/imager/general/599276/BioMarkers_775dfc64901f4612608e87a7497e295b.jpg); } } @media (max-width: 480px) { .inlay__bg--block-764258 { background-image: url(/imager/general/599276/BioMarkers_4de3145e4a5f7b68a5e3a7333ae49011.jpg); } } </style> <div class="section__bg section__bg--clr"></div> <div class="section__inner section__pad"> <div class="shell"> <div class="grid grid--xs"> <div class="grid__inner"> <div class="grid-item grid-item--full"> <div class="component component--inherit "> <div class="inlay"> <div class="shadow"></div> <div class="inlay__bg inlay__bg--img component__bgimg poster inlay__bg--block-764258"></div> <div class="inlay__bg inlay__bg--clr component__bgclr"></div> <div class="inlay__inner"> <div class="article color-blue"> <div class="article__inner component__cols"> <div class="article__main" data-aos="fade-up"> <h2>Reliable markers of biological age are here.</h2><p>For years researchers have sought markers that will reliably reveal biological age <br />as contrasted to chronological age. The DNA in our cells is ornamented with thousands of tiny chemical tags that help determine whether genes are turned on or off. During aging, these tags are rearranged, disappearing from some sites, appearing at others. Evidence has now accumulated that the overall pattern of these tags across the entire genome does indeed reliably indicate biological age in nearly any mammal species, including humans. It now appears as if such a biomarker for aging may have been discovered. </p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="section section--bigbar section--padxs-top section--padxs-bottom"> <div class="section__inner section__pad"> <div class="shell"> <div class="section__cols"> <div class="section__main"> <div class="component"> <div class="inlay"> <div class="inlay__inner"> <div class="article article--avatar article--avatarwrap color-blue"> <div class="article__inner component__cols"> <div class="article__main clear"> <div class="avatar avatar--alt"> <div class="avatar__inner"> <div class="avatar__image"> <img class="lazyload" data-src="/imager/general/544775/Levine-photo-2_6fef9ec64b256ad6bee8afabc362a09e.jpg" alt="Levine photo 2"> </div> </div> </div> <div class="article__content" data-aos="fade-up"> <h4><strong>Morgan Levine, PhD</strong></h4><p>2021 <a href="https://www.afar.org/vincent-cristofalo-award">Vincent Cristofalo Rising Star Award in Aging Research</a> recipient <strong>Morgan Levine, PhD</strong> is applying computational research to improve our understanding of biomarkers of aging.</p><p>Dr. Levine is an Assistant Professor, Yale Center for Research on Aging (Y-Age) in the Department of Pathology at Yale School of Medicine. She is the founder of the Laboratory for Aging in Living Systems (Levine Lab).</p> <div class="socials"> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="sidebar sidebar--big"> <div class="slider slider--embed slider--color color-blue"> <div class="slider__intro text-center"> <div class="shadow"></div> <h5>More from Dr. Levine</h5> </div> <div class="slider__inner"> <div class="grid swiper-container js-slider-embed"> <div class="grid__inner swiper-wrapper slider__slides"> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/general/602059/AgingJournalLogo_f7a9bdabdac5f4ef029b9375b1a4069f.jpg" alt="Aging Journal Logo"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <h5 class="color-yellow">Read</h5><p>Dr. Levine was the lead author on an article in Aging journal, "An epigenetic biomarker of aging for lifespan and healthspan."</p> </div> <div class="swiper-pagination"></div> </div> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940111/" class="card__link component__link" target="_blank"></a> </div> </div> </div> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/general/602172/LevineForesightInstitute_f7a9bdabdac5f4ef029b9375b1a4069f.jpg" alt="Levine Foresight Institute"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <h5 class="color-yellow">Watch</h5><p>Dr. Levine presented at the Foresight Institute on Biomarker Standardization.</p> </div> <div class="swiper-pagination"></div> </div> <a href="https://foresight.org/salon/biomarker-standardization-morgan-levine-yale-jamie-justice-wake-forest-school-of-medicine/" class="card__link component__link" target="_blank"></a> </div> </div> </div> </div> </div> <div class="slider-nav"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" 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