Blood Disorders and Blood Safety

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<li class='breadcrumb-home'><a href='/'>Home</a></li><li class='breacrumb-break'>/</li><li class='breadcrumb-parent'><a href='/node/80002'><span class='back-to'> < Back To </span>The Science</a></li><li class='breacrumb-break'>/</li><li class='breadcrumb-current'>Blood Disorders and Blood Safety</li></ul></div></div> <article class="node node--type-scientific-focus-area node--view-mode-full" data-title="Blood Disorders and Blood Safety" data-type="scientific_focus_area" data-format="" data-audience="" data-campaign="" > <div class="standard"> <div class="field field--name-field-top-texture-banner field--type-list-string field--label-hidden field__item"> <div class="pageBanner"> <div class="banner-new-light-red"></div> </div> </div> <div class="secondary-grey-background"> <div class="responsive-container responsive-container-constrained"> <div class="content-container page-top"> <div class="rtFlexContainer"> <div class="rtTitleClassification"> <h1> <span>Blood Disorders and Blood Safety</span> </h1> <div class="calloutdescription"> <div class="field field--name-field-definition field--type-string field--label-hidden field__item">Blood diseases affect millions of people each year. These inherited and acquired diseases, including the anemias, venous thromboembolism, hemophilia, and other bleeding disorders, can affect red and white blood cells, platelets, bone marrow, vascular endothelium, or plasma proteins. These conditions can cause blood cells to function abnormally, which may lead to disease or affect overall health. Blood safety involves keeping the Nation鈥檚 blood supply free of contaminants or infectious agents.</div> </div> </div> <div class="onThisPage"> <div class="pagenavtitle"> On this page </div> <ul> <li><a href="#makingadifference">Research Making a Difference</a></li> <li><a href="#whyimportant">Why It's Important</a></li> <li><a href="#keyaccomplishments">Key Accomplishments</a></li> <li><a href="#opportunities">Opportunities & Challenges</a></li> <li><a href="#advancingresearch">Advancing the Research</a></li> <li><a href="#relatedreading">Related Reading</a></li> </ul> </div> </div> </div> </div> </div> <div class="responsive-container responsive-container-constrained"> <div class="content-container research-making-a-difference"> <div class="field field--name-field-making-a-difference field--type-entity-reference-revisions field--label-hidden field__item"><div class="flexcontainer paragraph paragraph--type--making-a-difference paragraph--view-mode--default" id="makingadifference"> <h2 class="phone-display" id="makingadifference-phone">Research Making a Difference</h2> <div class="flexItemTextHalf"> <h2 class="desktop-tablet-display" id="makingadifference-desktop">Research Making a Difference</h2> <div class="pullquote"> Rapid result test may transform sickle cell disease screening for millions." </div> <div class="bodytext"> <div class="field field--name-field-research-description field--type-string field--label-hidden field__item">Soon after birth, babies in the United States are tested for sickle cell disease. In sub-Saharan Africa, however, where the majority of sickle cell disease cases can be found, newborn screening programs are rare, and as a result, there is a missed opportunity for early initiation of lifesaving treatment.</div> </div> <div class="desktop-display"> <div class="field field--name-field-url field--type-link field--label-hidden field__item"><a href="/news/2019/rapid-result-test-track-transform-sickle-cell-disease-screening-millions">Read more about how these tests can save children鈥檚 lives.</a></div> </div> </div> <div class="flexItemImageHalf"> <div class="image-and-photocredit-container"> <div class="field field--name-field-thumbnail field--type-image field--label-hidden field__item"> <img loading="lazy" src="/modules/custom/nhlbi_blazy/images/clear.png" width="768" height="512" alt="Two smiling kids with their mother" data-src="/sites/default/files/styles/16x9_crop/public/2022-09/SickleCellDisease_HT_900x600.jpg?itok=9A1LZcms" class="b-lazy image-style-_6x9-crop" /> </div> </div> </div> </div> <div class="tablet-phone-display"> <div class="field field--name-field-url field--type-link field--label-hidden field__item"><a href="/news/2019/rapid-result-test-track-transform-sickle-cell-disease-screening-millions">Read more about how these tests can save children鈥檚 lives.</a></div> </div> </div> </div> </div> <div class="pale-blue-darker-white-background"> <div class="responsive-container responsive-container-constrained"> <div class="content-container why-its-important storycalloutbox"> <div class="storycallouttitle" id="whyimportant"> <h2 class="why-its-important-header">WHY IT'S IMPORTANT</h2> </div> <div class="storycallouttext"> <div class="bodytext"> <div class="field field--name-field-why-important-description field--type-text-long field--label-hidden field__item"><p><span>NHLBI has several major research goals in blood diseases. One is to ensure the adequacy and safety of the nation鈥檚 blood supply. A second is to support efforts to treat and cure blood disorders, such as supporting scientific advances in stem cell biology and new gene and cell-based therapies to repair and regenerate human tissues and organs. By funding and supporting research on the causes, prevention, and treatment of blood disorders, we help researchers make new discoveries, leading to better medical care for the millions of people affected by blood disorders around the world.</span></p></div> </div> </div> </div> </div> </div> <div class="tertiaryBlueBackground"> <div class="responsive-container responsive-container-constrained"> <div class="content-container key-accomplishments storycalloutbox"> <div class="storycallouttitle" id="keyaccomplishments"> <h2 class="key-accomplishments-header">KEY ACCOMPLISHMENTS</h2> </div> <div class="storycallouttext storycalloutlist"> <div class="field field--name-field-key-accomplishments field--type-string field--label-hidden field__items"> <ul> <li><div class="field__item calloutdata font-size-xl">The NHLBI-led Cure Sickle Cell Initiative is a patient-focused research effort to develop genetic therapies for use in clinical research.</div></li> <li><div class="field__item calloutdata font-size-xl">NHLBI-sponsored research has helped and continues to help Americans with sickle cell disease live longer and stay well in adulthood.</div></li> <li><div class="field__item calloutdata font-size-xl">NHLBI-supported scientists developed lifesaving treatments for patients with hemophilia and are now working on gene therapy approaches to cure the disease.</div></li> <li><div class="field__item calloutdata font-size-xl">NHLBI-funded research helped develop therapies that increased the survival rates for patients who have aplastic anemia.</div></li> </ul> </div> </div> </div> </div> </div> <div class="responsive-container responsive-container-constrained"> <div class="content-container opportunities-and-challenges storycalloutbox"> <div class="storycallouttitle" id="opportunities"> <h2 class="opportunities-and-challenges-header">OPPORTUNITIES & CHALLENGES</h2> </div> <div class="storycallouttext"> <div class="field field--name-field-opportunities-description field--type-text-long field--label-hidden field__item"><p><span>NHLBI鈥檚 </span><a href="https://www.nhlbi.nih.gov/node/80111" rel="noreferrer"><span>Strategic Vision</span></a><span> guides the Institute鈥檚 research activities. Many of the objectives, compelling questions, and critical challenges identified in the plan focus on blood biology, blood disorders, and blood safety. Training the next generation of blood scientists is also a high priority for the NHLBI.</span></p></div> <div class="supplemental-accordion"> <div class="field field--name-field-opportunities-accordion field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <h3 class="graysubaccordionheading" id="more-information-743"> <div class="field field--name-field-panel-title field--type-string field--label-hidden field__item">More Information</div> <span class="ui-helper-hidden-accessible"> - Blood Disorders and Blood Safety </span> </h3> <div class="ui-accordion ui-widget ui-helper-reset paragraph paragraph--type--standard-accordion-panelparagraph--view-mode--default" > <div class="bodytext"> <div class="field field--name-field-accordion-body field--type-text-long field--label-hidden field__item"><p><span>Researchers are working across scientific disciplines to advance blood disorders research. The NHLBI assists in this effort by enabling early translational research to accelerate the development of new clinical interventions. Currently, we are supporting research resource programs that provide regulatory, pharmacology, toxicology, and manufacturing services to NHLBI investigators who conduct blood science research. The hope is for patients with blood disorders to live long and full lives and for the research to improve blood safety measures both in the United States and around the world.</span></p></div> </div> <div class="readMoreContainer"> </div> </div> </div> </div> </div> </div> </div> </div> <div class="pale-blue-darker-white-background"> <div class="responsive-container responsive-container-constrained"> <div class="content-container advancing-the-research"> <h2 id="advancingresearch">Advancing the Research</h2> <div class="field field--name-field-advancing-description field--type-text-long field--label-hidden field__item"><p>NHLBI is advancing blood disorders and blood safety research in many ways. Learn more about some of our key efforts related to sickle cell disease, anemia, blood transfusions, and more.</p></div> <div class="field field--name-field-sub-category field--type-entity-reference-revisions field--label-hidden field__items"> <div class="paragraph paragraph--type--sfa-sub-category paragraph--view-mode--default"> <div class="field field--name-field-sfa-card field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="science-instance-card"> <div class="field field--name-field-icon field--type-list-string field--label-hidden field__item"> <div class="card-icon"> <div class="card-icon-branch-lab"></div> </div> </div> <h3> <div class="field field--name-field-card-title field--type-string field--label-hidden field__item">We Perform Research</div> </h3> <div class="bodytext"> <div class="field field--name-field-description field--type-text-long field--label-hidden field__item"><p><span class="eop">The NHLBI </span><a href="https://www.nhlbi.nih.gov/node/80034" rel="noreferrer"><span><strong>Division of Intramural Research</strong></span></a><span class="eop"> and its </span><a href="https://www.nhlbi.nih.gov/node/80015" rel="noreferrer"><span><strong>Hematology Branch</strong></span></a><span class="eop">, </span><a href="https://www.nhlbi.nih.gov/node/80019" rel="noreferrer"><span><strong>Sickle Cell Branch</strong></span></a><span class="eop">, and Sickle Cell Program include investigators who are actively engaged in research on blood disorders and blood safety.</span></p></div> </div> </div> </div> <div class="field__item"> <div class="science-instance-card"> <div class="field field--name-field-icon field--type-list-string field--label-hidden field__item"> <div class="card-icon"> <div class="card-icon-branch-lab"></div> </div> </div> <h3> <div class="field field--name-field-card-title field--type-string field--label-hidden field__item">We Fund Research</div> </h3> <div class="bodytext"> <div class="field field--name-field-description field--type-text-long field--label-hidden field__item"><p><span class="eop">The research we fund today will help improve our future health. Our </span><a href="https://www.nhlbi.nih.gov/node/80029" rel="noreferrer"><span><strong>Division of Blood Diseases and Resources</strong></span></a><span class="eop"> is a leader in research on the causes, prevention, and treatment of blood diseases (other than cancers of blood cells). The NHLBI鈥檚 </span><a href="https://www.nhlbi.nih.gov/node/80036" rel="noreferrer"><span><strong>Division of Cardiovascular Sciences</strong></span></a><span class="eop"> also supports some blood science鈥搑elated research.</span></p></div> </div> </div> </div> <div class="field__item"> <div class="science-instance-card"> <div class="field field--name-field-icon field--type-list-string field--label-hidden field__item"> <div class="card-icon"> <div class="card-icon-programs"></div> </div> </div> <h3> <div class="field field--name-field-card-title field--type-string field--label-hidden field__item">The Promise of Precision Medicine</div> </h3> <div class="bodytext"> <div class="field field--name-field-description field--type-text-long field--label-hidden field__item"><p><span class="eop">Through NHLBI鈥檚 </span><a href="https://www.nhlbi.nih.gov/node/80055" rel="noreferrer"><span><strong>Trans-Omics for Precision Medicine (TOPMed) program</strong></span></a><span class="eop">, researchers will use data from studies focused on heart, lung, blood, and sleep disorders to better predict, prevent, diagnose, and treat blood disorders based on a patient鈥檚 unique genes, environment, and molecular signatures. Learn more about NHLBI </span><a href="https://www.nhlbi.nih.gov/node/80042" rel="noreferrer"><span><strong>precision medicine activities</strong></span></a><span class="eop">.</span></p></div> </div> </div> </div> <div class="field__item"> <div class="science-instance-card"> <div class="field field--name-field-icon field--type-list-string field--label-hidden field__item"> <div class="card-icon"> <div class="card-icon-consortium"></div> </div> </div> <h3> <div class="field field--name-field-card-title field--type-string field--label-hidden field__item">Funding Global Health Research Efforts</div> </h3> <div class="bodytext"> <div class="field field--name-field-description field--type-text-long field--label-hidden field__item"><p><span class="eop">More than 75 percent of infants with sickle cell disease (SCD) are born in sub-Saharan Africa. By funding the SCD in Sub-Saharan Africa (SSA) Network, which includes a Clinical Coordinating Center, a Sickle Africa Data Coordinating Center, and established and new consortium sites, we are building the regional capabilities to research sickle cell disease and monitor patients in Africa. These efforts may ultimately improve treatment and care for Americans who have sickle cell disease.</span></p></div> </div> </div> </div> <div class="field__item"> <div class="science-instance-card"> <div class="field field--name-field-icon field--type-list-string field--label-hidden field__item"> <div class="card-icon"> <div class="card-icon-programs"></div> </div> </div> <h3> <div class="field field--name-field-card-title field--type-string field--label-hidden field__item">Improving Blood Safety and Availability</div> </h3> <div class="bodytext"> <div class="field field--name-field-description field--type-text-long field--label-hidden field__item"><p><span class="eop">The NHLBI started the </span><a href="https://www.nhlbi.nih.gov/node/80052" rel="noreferrer"><span><strong>Recipient Epidemiology and Donor Evaluation Study (REDS) program</strong></span></a><span class="eop"> in 1989 to protect the nation鈥檚 blood supply from threats, improve the benefits of transfusions, and reduce the risks of transfusions. REDS is the largest multicenter research program of its kind in the United States, and after 30 years, it is entering a new, important phase. It now aims to evaluate and improve the safety and effectiveness of transfusion therapies with attention not only to adults but also to understudied populations, including newborns and children.</span></p></div> </div> </div> </div> <div class="field__item"> <div class="science-instance-card"> <div class="field field--name-field-icon field--type-list-string field--label-hidden field__item"> <div class="card-icon"> <div class="card-icon-consortium"></div> </div> </div> <h3> <div class="field field--name-field-card-title field--type-string field--label-hidden field__item">Addressing Issues in Blood and Marrow Transplantation</div> </h3> <div class="bodytext"> <div class="field field--name-field-description field--type-text-long field--label-hidden field__item"><p><span class="eop">The </span><a href="https://web.emmes.com/study/bmt2/index.html" rel="noreferrer"><span><strong>Blood and Marrow Transplant Clinical Trials Network (BMT CTN)</strong></span></a><span class="eop"> was established to conduct large, multi-institutional clinical trials to understand the best possible treatment approaches in blood and marrow transplantation. In the United States, nearly 21,000 patients receive blood or marrow transplants annually, mainly for rare blood disorders.</span></p></div> </div> </div> </div> <div class="field__item"> <div class="science-instance-card"> <div class="field field--name-field-icon field--type-list-string field--label-hidden field__item"> <div class="card-icon"> <div class="card-icon-programs"></div> </div> </div> <h3> <div class="field field--name-field-card-title field--type-string field--label-hidden field__item">Studying Underlying Factors in Severe Trauma Cases</div> </h3> <div class="bodytext"> <div class="field field--name-field-description field--type-text-long field--label-hidden field__item"><p><span class="eop">The </span><span><strong>Trans-Agency Research Consortium for Trauma-Induced Coagulopathy (TACTIC)</strong></span><span class="eop"> research program is no longer active but completed important work. It was established in collaboration with the U.S. Department of Defense to study the disruptions in the normal process of blood clotting that occur in individuals who experience severe physical trauma. Trauma, particularly severe trauma, can disturb the body鈥檚 mechanisms for stopping hemorrhage or lead to the overproduction of blood clots, both of which can cause major or even fatal complications.</span></p></div> </div> </div> </div> <div class="field__item"> <div class="science-instance-card"> <div class="field field--name-field-icon field--type-list-string field--label-hidden field__item"> <div class="card-icon"> <div class="card-icon-programs"></div> </div> </div> <h3> <div class="field field--name-field-card-title field--type-string field--label-hidden field__item">Supporting scientists performing NHLBI-funded gene therapy research</div> </h3> <div class="bodytext"> <div class="field field--name-field-description field--type-text-long field--label-hidden field__item"><p><span>Research on </span><a href="https://www.nhlbi.nih.gov/health-topics/genetic-therapies" rel="noreferrer"><span><strong>genetic therapies</strong></span></a><span> is part of our broader commitment to advancing scientific discovery aimed at developing safe and effective treatments for heart, lung, and blood disorders and diseases caused by faulty genes. Our </span><a href="https://ngvbcc.org/" rel="noreferrer"><span><strong>National Gene Vector Biorepository</strong></span></a><span> and<strong> </strong></span><a href="https://www.gtrp.org/" rel="noreferrer"><span><strong>Gene Therapy Resource Program</strong></span></a><span> help investigators transform early-stage research into genetic therapies. These programs equip scientists with the tools, resources, safety testing services, and animal models they need to advance genetic therapy research from the laboratory into clinical trials.</span></p></div> </div> </div> </div> </div> </div> </div> <a class="viewmorebutton" href = "/science/all-science?field_related_sfas_target_id=80037" >View all science about Blood Disorders and Blood Safety </a> </div> </div> </div> <a id="relatedreading"></a> <div class="responsive-container responsive-container-constrained"> <div class="content-container-margin"> <div class="related-ht-press-container"> <div class="card"> <h2>Related Health Topics</h2> <div class="related-topics"> <div class="field field--name-field-related-health-topics field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/health/sickle-cell-disease" hreflang="en">What Is Sickle Cell Disease?</a></div> <div class="field__item"><a href="/health/anemia" hreflang="en">What Is Anemia?</a></div> <div class="field__item"><a href="/health/blood-bone-marrow-treatments" hreflang="en">Treatments for Blood Disorders</a></div> </div> </div> </div> </div> </div> </div> <div class="tertiaryBlueBackground"> <div class="responsive-container responsive-container-constrained"> <div class="content-container-margin"> <div class="field field--name-field-related-news-single field--type-entity-reference field--label-hidden field__item"> <h2><div class="whitesubhead font-size-l"> RELATED NEWS </div></h2> <article class="featured-science-instance-teaser-container node node--type-feature-article node--promoted node--view-mode-featured-science-instance-teaser"> <div class="flexItemImageThird"> <div class="image-and-photocredit-container"> <div class="field field--name-field-hero-image field--type-image field--label-hidden field__item"> <img loading="lazy" src="/modules/custom/nhlbi_blazy/images/clear.png" width="768" height="432" alt="A pregnant woman in deep thought looks out a window" data-src="/sites/default/files/styles/16x9_crop/public/2023-09/shutterstock_1565039914.jpg?h=ab94ba44&itok=3xi4LQ0l" class="b-lazy image-style-_6x9-crop" /> </div> </div> </div> <div class="flexTextWithImage flexItemText"> <div class="font-size-l bannerdate"> <time datetime="2023-09-13T14:00:00Z" class="datetime"><span>September 13, 2023</span></time> <div class="paddedBar"> | </div> Research Feature </div> <div class="herobannertitle" > <a href="/news/2023/pregnant-and-living-sickle-cell-disease-push-better-outcomes" rel="bookmark"> <span>Pregnant and Living with Sickle Cell Disease: A Push for Better Outcomes</span> </a> </div> <div class="bodytext"> <div class="field field--name-field-additional-introduction field--type-text-long field--label-hidden field__item"> Wemi Found, a mother of two who has sickle cell disease (SCD), barely survived her first pregnancy. The Toronto resident was elated to be pregnant; it had taken nearly a year to conceive during which she also experienced a devastating miscarriage. The first trimester of her pregnancy was a breeze, Found recalled during a recent NHLBI-funded... </div> </div> </div> </article> </div> </div> </div> </div> <div class="responsive-container responsive-container-constrained"> <div class="content-container-margin"> <div class="views-element-container"><div class="view view-nhlbi-news-science view-id-nhlbi_news_science view-display-id-block_5 js-view-dom-id-1234bbb30e9d83cf2b11b750a5448d37f7d7b3681585f45278d518475dd250d0"> <div class="view-content"> <div class="views-row"> <h2><div class="blackstandardsubhead font-size-l"> RELATED EVENT </div></h2> <article class="featured-science-instance-teaser-container node node--type-events node--view-mode-featured-science-instance-teaser"> <div class="flexItemImageThird"> <div class="image-and-photocredit-container"> <div class="field field--name-field-hero-image field--type-image field--label-hidden field__item"> <img loading="lazy" src="/modules/custom/nhlbi_blazy/images/clear.png" width="768" 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