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Technological Innovations in Drug Discovery and Development – Pharma
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class="inside-article"> <div class="featured-image page-header-image-single "> <img width="1200" height="628" src="https://thepharma.net/archive/wp-content/uploads/2024/09/image-_30_-min-scaled-e1727173765518.jpg" class="attachment-full size-full" alt="" itemprop="image" decoding="async" fetchpriority="high" /> </div> <header class="entry-header"> <h1 class="entry-title" itemprop="headline">Technological Innovations in Drug Discovery and Development</h1> <div class="entry-meta"> <span class="posted-on"><time class="entry-date published" datetime="2024-09-24T15:59:33+05:30" itemprop="datePublished">September 24, 2024</time></span> <span class="byline">by <span class="author vcard" itemprop="author" itemtype="https://schema.org/Person" itemscope><a class="url fn n" href="https://thepharma.net/archive/author/thepharma/" title="View all posts by thepharma" rel="author" itemprop="url"><span class="author-name" itemprop="name">thepharma</span></a></span></span> </div> </header> <div class="entry-content" itemprop="text"> <p><span style="font-weight: 400;">The drug discovery and development landscape has witnessed a remarkable shift over the years, impacting a state-of-the-art technological era in these fields. Innovations from semantic web tools through the block chain carry the study and production of pharmaceuticals to a completely new level. In fact, the adoption of these technologies has become indispensable to seeking improvements in efficiency, accuracy, and transparency. In this paper, we will present an overview of the different technologies involved in revolutionizing the area of drug discovery and development, their applications and benefits, and the potential of solving some of the timeless problems with this industry. Semantic web in drug discovery.</span></p> <p><span style="font-weight: 400;">In drug discovery, semantic web technologies offer handling large amounts of data in a structured, interoperable, and comparable manner, having picked up real speed. These technologies help model and represent data in an integrative manner, hence allowing the opening up of new research avenues by identifying either unrecognized connections between drugs, targets, or diseases. The shared semantic resources in these tools and their knowledge graphs will empower context-dependent searches across numerous datasets to improve the precision and efficiency of the drug discovery process.</span></p> <p><span style="font-weight: 400;">One of the key advantages of semantic web technologies arises from their support for machine learning applications in drug discovery. With the help of semantic links, machine learning algorithms developed with knowledge graphs can lead to better predictions and highlight new effective drug-target interactions. Such an approach accelerates the process of drug discovery and helps improve precision in identifying potential therapeutic candidates.</span></p> <p></div></div> <div style="background: #f7f7f7;border: 1px solid rgba(0, 0, 0, 0.07);"> <div style="padding: 30px;"><div class="Adblock-main"> <div class="Adblock-head"> <h2>Yearwise Publication Trend on <b>“<a href="https://thepharma.net/publication-trends/index/drug discovery" target="_blank" title="drug discovery - yearwise publication trends">drug discovery</a>”</b></h2> </div> </div><div class="results-container"><div class="chart-block" style="padding:15px;"> <div class="left"> <div id="results" class="results"></div> </div> <div class="right"> <div class="chart-container"><canvas id="publicationChart"></canvas></div> </div> <div class="keywordsdiv"> <div style="text-align:center;"><b>Find publication trends on relevant topics</b> </div> <span class="gp-icon icon-tags"><svg viewBox="0 0 512 512" aria-hidden="true" xmlns="http://www.w3.org/2000/svg" width="1em" height="1em"><path d="M20 39.5c-8.836 0-16 7.163-16 16v176c0 4.243 1.686 8.313 4.687 11.314l224 224c6.248 6.248 16.378 6.248 22.626 0l176-176c6.244-6.244 6.25-16.364.013-22.615l-223.5-224A15.999 15.999 0 00196.5 39.5H20zm56 96c0-13.255 10.745-24 24-24s24 10.745 24 24-10.745 24-24 24-24-10.745-24-24z"></path><path d="M259.515 43.015c4.686-4.687 12.284-4.687 16.97 0l228 228c4.686 4.686 4.686 12.284 0 16.97l-180 180c-4.686 4.687-12.284 4.687-16.97 0-4.686-4.686-4.686-12.284 0-16.97L479.029 279.5 259.515 59.985c-4.686-4.686-4.686-12.284 0-16.97z"></path></svg></span> <span id="keyword-stats"></span> </div> </div></div></div><div class="inside-article"><style> table { margin: 0 0 1.5em; 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Such technologies provide a common framework for seamless data sharing and collaboration among researchers, pharmaceutical companies, and many other stakeholders. Web ontologies thus make these networked and collaborative efforts in drug discovery more efficient and effective, uniting diversified resources.</span></p> <p><span style="font-weight: 400;">Semantic web service technology provides general infrastructure for collaboration among researchers, hence increasing pipeline productivity. This technology offers ways for the publication of data semantically, thus providing an escape. from isolation depending on pure content analysis in text to efficient semantic data mining. The capability of linking open data in integrated drug discovery is one of many abilities that makes the retrieval and usage of a wider scope of information in assisting mining efforts easy for the researcher.</span></p> <h3><b>Advanced Computational Methods in Fighting Counterfeit Medicines</b></h3> <p><span style="font-weight: 400;">Globalization has brought new factors of complexity into the pharmaceutical supply chain, especially in combating fake medicine trafficking. New advanced computational methods, including blockchain technology and mobile solutions, are now developing as forceful tools for taking up these challenges. Such technologies provide innovative solutions for safeguarding patients across the world through the integrity and authenticity processes of pharmaceutical products.</span></p> <p><span style="font-weight: 400;">For example, block chain technology provides a decentralized, immutable ledger for all transactions, ensuring the integrity of the data. This, in turn, will provide tractability over the entire lifecycle of a drug, right from the period of manufacture to that of delivery, at every mode of the supply chain. Because of block chain technology, the pharmaceutical industry will be able to easily trace the origin of the manufactured drugs and ensure that these drugs avoid the market, ensuring that both patients and drugs are safe from factors that threaten their health stability.</span></p> <h3><b>Block chain and IoT for Safe Pharmaceutical Delivery</b></h3> <p><span style="font-weight: 400;">The coverage of block chain and IoT technology in drug delivery has revolutionized this supply chain, ensuring safety and efficiency at every step. A combination of block chain and IoT sensors makes it possible to monitor the temperature, humidity levels, and other environmental factors that could affect the condition in which drugs have to be maintained during storage and transportation. When these are combined with block chain technology, we get a proof-of-delivery record of the drug from the marketer to the end-user.</span></p> <p><span style="font-weight: 400;">The approach increases traceability and security with pharmaceutical products and reduces the risk of counterfeit drugs. The technology provides a secure system for the management of the pharmaceutical supply chain, wherein only authorized parties can obtain access to the block chain and edit it. This innovation is crucially important for vaccines and other temperature-sensitive medications, where the integrity of the supply line means everything with regard to efficacy and safety.</span></p> <h3><b>Data Integrity in Pharmaceutical Manufacturing</b></h3> <p><span style="font-weight: 400;">Pharmaceutical manufacturing is considered an activity that incorporates data integrity and significantly influences the safety of a patient while determining the financial prosperity of the companies that are engaged in the manufacturing process. Regulatory agencies such as the FDA have taken steps toward laying down guidelines that would ensure data accuracy and integrity right from the process of development and then final manufacturing. In order to take on the challenges involved in data integrity, technological solutions such as block chain and version control systems are put into use.</span></p> <p><span style="font-weight: 400;">Block chain technology is immutable and decentralized, providing a study solution for data integrity in the manufacturing of pharmaceuticals. With Ethereum possibly being one popular and mainstream platform, this tool can allow companies to create very transparent and hence auditable trails of data, starting from raw materials right to finished products. Not only will this increase the trustworthiness of manufacturing data, but with this clearly unchangeable record of transactions, the complexity related to compliance with regulatory requirements is simplified.</span></p> <h3><b>Block chain-Enabled Smart Containers for Vaccine Distribution</b></h3> <p><span style="font-weight: 400;">The distribution of vaccines and other temperature-sensitive medicinal materials is such an up-and-coming task, with the means of keeping them at the required conditions during transmission. This has, nevertheless, been corrected thanks to the block chain-enabled smart containers that bring together the use of IoT sensors and block chain technology in tracking and recording the conditions under which shipments are exposed in real time.</span></p> <p><span style="font-weight: 400;">These smart containers will, in turn, detect and respond to the slightest FDA violations in their storage conditions so as to deliver guaranteed vaccine effectiveness. This is where block chain technology comes in to secure all the data being acquired by these sensors, make this data tamper-proof, and provide an immutable, auditable trail of vaccines. Such innovation does not only assure enhanced safety and effectiveness but, in general, builds trust among health providers and patients.</span></p> <p></div></div> <div style="background: #f7f7f7;border: 1px solid rgba(0, 0, 0, 0.07);"> <div style="padding: 30px;"><div class="Adblock-main"> <div class="Adblock-head"> <h2>Recent Publications on <b>“<a href="https://thepharma.net/recent-publications/index/drug discovery" target="_blank" rel="noopener" title="drug discovery - yearwise publication list">drug discovery</a>”</b></h2> </div> </div> <div class="pb-main"><div class="article-scroll"><div id="results_recent" class="results"></div></div><div class="keywordsdiv" style="margin: 0px 15px;margin-top:20px;"> <div style="text-align:center;"><b>Find publications on relevant topics</b> </div> <span class="gp-icon icon-tags"><svg viewBox="0 0 512 512" aria-hidden="true" xmlns="http://www.w3.org/2000/svg" width="1em" height="1em"><path d="M20 39.5c-8.836 0-16 7.163-16 16v176c0 4.243 1.686 8.313 4.687 11.314l224 224c6.248 6.248 16.378 6.248 22.626 0l176-176c6.244-6.244 6.25-16.364.013-22.615l-223.5-224A15.999 15.999 0 00196.5 39.5H20zm56 96c0-13.255 10.745-24 24-24s24 10.745 24 24-10.745 24-24 24-24-10.745-24-24z"></path><path d="M259.515 43.015c4.686-4.687 12.284-4.687 16.97 0l228 228c4.686 4.686 4.686 12.284 0 16.97l-180 180c-4.686 4.687-12.284 4.687-16.97 0-4.686-4.686-4.686-12.284 0-16.97L479.029 279.5 259.515 59.985c-4.686-4.686-4.686-12.284 0-16.97z"></path></svg></span> <span id="keyword-papers"></span> </div></div></div><div class="inside-article"> <style> .pb-main{ border: solid 1px #ccc; border-top: none; margin-bottom: 20px; padding-bottom: 25px; background:#fff; } .author-main { border: solid 1px #ccc; border-top: none; margin-bottom: 20px; padding-bottom: 25px; background:#fff; } .publication-block { padding: 10px; margin-bottom: 10px; background-color: #f9f9f9; text-align: left; background: #FFF; border-bottom: solid 1px #ccc; margin-left: 15px; margin-right: 15px; } .publication-block h3 { margin: 0 0 10px; color: #000!important; } .publication-block a { font-size: 16px !important; line-height: 1em; font-weight: 600; text-transform: none; color: #000; padding: 0px; } .publication-block a:hover{ color: #227cdc; text-decoration:underline; } .article-scroll { max-height: 445px; overflow-y: auto; overflow-x: hidden; } ::-webkit-scrollbar-track { -webkit-box-shadow: inset 0 0 6px rgba(0,0,0,0.3); background-color: #efefef; border-radius:30px; } ::-webkit-scrollbar { width: 6px; background-color: #efefef; border-radius:30px; } ::-webkit-scrollbar-thumb { background-color: #ababab; 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var keywordsArray = ["Drug Discovery","Semantic Web Technologies","Blockchain","IoT","Pharmaceutical Supply Chain","Data Integrity","Smart Contracts","Clinical Trials","Vaccine Distribution","Counterfeit drugs"]; displayResults_recent(recent_papers); displayKeywordPapers(keywordsArray); // function stripslashes(str) { // if (typeof str === 'string') { // return str.replace(/\/g, ''); // } // } </script></p> <h3><b>The Future of Smart Contracts in Healthcare</b></h3> <p><span style="font-weight: 400;">Smart contracts, self-executing contracts where all the terms of the agreement are directly written into code, hold immense potential for disrupting every area related to healthcare, from clinical trials to data management. With block chain-backed technology, smart contracts efficiently automate and streamline processes by reducing the need for many intermediaries and ensuring the integrity of data.</span></p> <p><span style="font-weight: 400;">With clinical trials, it would be easier to introduce the utilization of smart contracts in the automation of patient consent, the collection of data, and the assurance of regulatory compliance. Through it, the data collection and storage process will be secure from any form of manipulative risk that might compromise the credibility of the results from trials. Additionally, smart contracts also make it easy for an effective collaboration process among researchers, regulators, and pharmaceutical companies in a better way to speed up drug development processes. This reduces supply chain risks through the use of block chain technology.</span></p> <p><span style="font-weight: 400;">It is, to a large extent, a complex pharmaceutical supply chain with many players, hence inherently prone to many risks of counterfeit drugs and supply chain disruptions. Block chain technology provides a good solution to these challenges by offering a secure and, at the same time, transparent system for tracking and managing the supply chain.</span></p> <p><span style="font-weight: 400;">It is through the supply chain that the traceability of products by pharmaceutical companies is highly boosted, leaving no chance for inaccuracies within the supply chain. Such business practices not only allow a minimal incidence of counterfeit drugs but also maximum efficiency and dependability in the supply chain. If there is a need for a recall, block chain technology facilitates the fast and efficient pinpointing and exclusion of products from the market, therefore ensuring the safety of patients with minimal financial losses.</span></p> <h3><b>Conclusion</b></h3> <p><span style="font-weight: 400;">The novel technologies are revolutionizing drug discovery and development, setting aside the old tools and methods to replace them with new ones, thereby increasing efficiency, accuracy, and transparency. Starting from applications with semantic web technologies and advanced computational methods to the use of block chains and the internet of things, innovations can solve some traditional problems encountered by the pharmaceutical industry. Being increasingly adopted and refined by researchers and companies, future drug discovery and development are promising to deliver more effective and safe treatments to patients across the globe.</span></p> <p></p> <h3><b>References</b></h3> <ol> <li>Kanza, S. and Frey, J.G., 2019. <a href="https://www.tandfonline.com/doi/full/10.1080/17460441.2019.1586880">A new wave of innovation in Semantic web tools for drug discovery.</a> <i>Expert Opinion on Drug Discovery</i>, <i>14</i>(5), pp.433-444.</li> <li>Chen, H. and Xie, G., 2010. <a href="https://www.tandfonline.com/doi/abs/10.1517/17460441003762709">The use of web ontology languages and other semantic web tools in drug discovery.</a> <i>Expert Opinion on Drug Discovery</i>, <i>5</i>(5), pp.413-423.</li> <li>Mackey, T.K. and Nayyar, G., 2017. <a href="https://www.tandfonline.com/doi/abs/10.1080/14740338.2017.1313227">A review of existing and emerging digital technologies to combat the global trade in fake medicines.</a> <i>Expert opinion on drug safety</i>, <i>16</i>(5), pp.587-602.</li> <li>Premkumar, A. and Srimathi, C., 2020, <a href="https://ieeexplore.ieee.org/abstract/document/9074264">March. Application of blockchain and IoT towards pharmaceutical industry.</a> In <i>2020 6th International Conference on Advanced Computing and Communication Systems (ICACCS)</i> (pp. 729-733). IEEE.</li> <li>Steinwandter, V. and Herwig, C., 2019. <a href="https://journal.pda.org/content/73/4/373.short">Provable data integrity in the pharmaceutical industry based on version control systems and the blockchain.</a> <i>PDA Journal of Pharmaceutical Science and Technology</i>, <i>73</i>(4), pp.373-390.</li> <li>Alkhoori, O., Hassan, A., Almansoori, O., Debe, M., Salah, K., Jayaraman, R., Arshad, J. and Rehman, M.H.U., 2021. <a href="https://ieeexplore.ieee.org/abstract/document/9395097">Design and implementation of CryptoCargo: A blockchain-powered smart shipping container for vaccine distribution.</a> <i>IEEE Access</i>, <i>9</i>, pp.53786-53803.</li> <li> <div class="citation-text">Nugent T, Upton D, Cimpoesu M. <a href="https://pubmed.ncbi.nlm.nih.gov/28357041/">Improving data transparency in clinical trials using blockchain smart contracts.</a> F1000Res. 2016 Oct 20;5:2541. doi: 10.12688/f1000research.9756.1. PMID: 28357041; PMCID: PMC5357027.</div> </li> <li>Alladi, T., Chamola, V., Rodrigues, J.J. and Kozlov, S.A., 2019. <a href="https://www.mdpi.com/1424-8220/19/22/4862">Blockchain in smart grids: A review on different use cases.</a> <i>Sensors</i>, <i>19</i>(22), p.4862.</li> </ol> <p></div></div> <div style="background: #f7f7f7;border: 1px solid rgba(0, 0, 0, 0.07);"> <div style="padding: 30px;"><div class="Adblock-main"> <div class="Adblock-head"> <h2>Top Experts on “<b style="color:#000;font-size:22px;">drug discovery</b>“</h2> </div> </div><div class="author-main"><div id="results_author"></div><div style="text-align: center;"><a class="register-button" href="https://thepharma.net/expert-search" target="_blank" rel="noopener">Find experts on any field</a></div></div><div class="inside-article" style="background: none;border: none;box-shadow: none;margin-top: -70px;"> <style> .author-block { padding: 15px; margin-bottom: 10px; text-align: left; font-size: 15px; line-height: 1.2; background: #FFF; border-bottom: solid 1px #ccc; margin-left: 15px; margin-right: 15px; } .author-block h3 { margin: 0 0 10px; color: #227cdc; } .author-block p { margin: 5px 0; } .author-b { display: flex; justify-content: space-between; flex-wrap: wrap; margin-bottom:10px; } .author-b .ainfo { flex: 1 1 30%; box-sizing: border-box; text-align: left; background: #dcdcdc; padding: 7px 14px; border-radius: 5px; margin-top: 3px; margin-right: 10px; } @media (max-width: 768px) { .author-b .ainfo { flex: 1 1 100%; margin: 10px 0; } } </style> <script> function displayResults_author(authors) { var resultsContainer = document.getElementById('results_author'); resultsContainer.innerHTML = ''; if (!authors || Object.keys(authors).length === 0) { resultsContainer.innerHTML = '<p>No authors found.</p>'; return; } Object.values(authors).slice(0, 10).forEach(author => { if (author.affiliation.length > 400) { return; } var authorBlock = document.createElement('div'); authorBlock.className = 'author-block'; var author_name=author.name; let key_replace = author_name.replace(/ /g, '-'); key_replace = key_replace.toLowerCase(); var authorHTML = ` <h3><a href="https://thepharma.net/author/index/${key_replace}\/${author.aid}" target="_blank" title="${author.name}">${author.name}</a></h3> <div class="author-b"> <div class="ainfo"><strong>H-Index:</strong> ${author.hindex}</div> <div class="ainfo"><strong>Publication Count:</strong> ${author.paper_count}</div> <div class="ainfo"><strong>Citation Count:</strong> ${author.citation_count}</div> </div> <p><strong>Affiliation:</strong> ${author.affiliation}</p> `; authorBlock.innerHTML = authorHTML; resultsContainer.appendChild(authorBlock); }); } function displayKeywordAuthors(keywords) { var resultsContainer = document.getElementById('keyword-authors'); resultsContainer.innerHTML = ''; if (!keywords || keywords.length === 0) { resultsContainer.innerHTML = '<p>No data found.</p>'; return; } var keywordHTML = ''; keywords.forEach(key => { let key_replace = key.replace(/ /g, '-'); key_replace = key_replace.toLowerCase(); keywordHTML += `<a href="https://thepharma.net/expert-search/index/${key_replace}" target="_blank" title="${key}">${key}</a>`; }); resultsContainer.innerHTML = keywordHTML; } // Call the function with the PHP data var authors_data = { "rTU-K4wBWBy50K-rAIin": { "aid": "rTU-K4wBWBy50K-rAIin", "name": "P. 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