当归多糖促进骨髓移植重建受体小鼠造血功能

<!DOCTYPE html> <html> <head> <META NAME="GENERATOR" CONTENT="北京玛格泰克科技发展有限公司"> <meta http-equiv="Content-Type" content="text/html; charset=utf-8"> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <Meta http-equiv="Content-Language" Content="zh-CN">  <meta name="citation_issn" content="0529-1356" /> <meta name="citation_journal_title" xml:lang="zh" content="解剖学报" /> <meta name="citation_journal_title" xml:lang="en" content="Acta Anatomica Sinica" /> <meta name="citation_language" content="zh" /> <meta name="citation_volume" content="55" /> <meta name="citation_issue" content="5" /> <meta name="citation_firstpage" content="556" /> <meta name="citation_id" content="55/5/556" /> <meta name="citation_doi" content="10.16098/j.issn.0529-1356.2024.05.006" /> <meta name="citation_title" xml:lang="zh" content="当归多糖促进骨髓移植重建受体小鼠造血功能" /> <meta name="citation_title" xml:lang="en" content=" Angelica Sinensis polysaccharide promoting hematopoietic reconstruction in receptor mice after bone marrow transplantation " /> <meta name="citation_authors" xml:lang="zh" content="杨婷廖奎黄彩虹魏晗王程杜坤航汪子铃王璐王亚平" /> <meta name="citation_authors" xml:lang="en" content="YANG Ting LIAO Kui HUANG Cai-hong WEI Han WANG Cheng DU Kun-hang WANG Zi-ling WANG Lu WANG Ya-ping " /> <meta name="citation_publication_date" content="2024-10-06" /> <meta name="citation_online_date" content="2024-10-06" /> <meta name="citation_keywords" xml:lang="zh" content="当归多糖｜X射线辐射｜骨髓移植｜造血重建｜骨髓微环境｜免疫荧光｜实时定量聚合酶链反应｜小鼠&nbsp" /> <meta name="citation_keywords" xml:lang="en" content="Angelica Sinensis polysaccharide｜X-ray radiation" /> <meta name="citation_keywords" xml:lang="en" content="Bone marrow transplantation｜Hematopoietic reconstruction｜Bone marrow microenvironment｜Immunofluorescence｜Real-time PCR｜Mouse" /> <meta name="Description" xml:lang="zh" content=" 目的   探讨当归多糖（ASP）调..." /> <meta name="Description" xml:lang="en" content=" Objective   To explore the mechanism of Angelica Sinensis..." /> <meta name="citation_abstract_html_url" xml:lang="zh" content="https://jpxb.bjmu.edu.cn/CN/10.16098/j.issn.0529-1356.2024.05.006" /> <meta name="citation_abstract_html_url" xml:lang="en" content="https://jpxb.bjmu.edu.cn/EN/10.16098/j.issn.0529-1356.2024.05.006" /> <meta name="citation_pdf_url" content="https://jpxb.bjmu.edu.cn/CN/article/downloadArticleFile.do?attachType=PDF&id=2859" /> <meta name="DC.Format" content="text/html" /> <meta name="DC.Language" content="zh" /> <meta name="DC.Title" content="当归多糖促进骨髓移植重建受体小鼠造血功能" /> <meta name="DC.Identifier" content="10.16098/j.issn.0529-1356.2024.05.006" /> <meta name="DC.Contributor" content="杨婷" /> <meta name="DC.Contributor" content="廖奎" /> <meta name="DC.Contributor" content="黄彩虹" /> <meta name="DC.Contributor" content="魏晗" /> <meta name="DC.Contributor" content="王程" /> <meta name="DC.Contributor" content="杜坤航" /> <meta name="DC.Contributor" content="汪子铃" /> <meta name="DC.Contributor" content="王璐" /> <meta name="DC.Contributor" content="王亚平" /> <meta name="DC.Date" content="2024-10-06" /> <meta name="DC.Keywords" xml:lang="zh" content="当归多糖｜X射线辐射｜骨髓移植｜造血重建｜骨髓微环境｜免疫荧光｜实时定量聚合酶链反应｜小鼠&nbsp,"/> <meta name="DC.Keywords" xml:lang="en" content="Angelica Sinensis polysaccharide｜X-ray radiation,Bone marrow transplantation｜Hematopoietic reconstruction｜Bone marrow microenvironment｜Immunofluorescence｜Real-time PCR｜Mouse,"/> <meta name="robots" content="index" /> <title>当归多糖促进骨髓移植重建受体小鼠造血功能</title>  <link href="https://jpxb.bjmu.edu.cn/js/bootstrap/css/bootstrap.min.css" rel="stylesheet"> <link rel="stylesheet" href="https://jpxb.bjmu.edu.cn/images/0529-1356/css/css.css"> <link href="https://jpxb.bjmu.edu.cn/js/bootstrap/css/font-awesome.min.css" rel="stylesheet">  <script src="https://jpxb.bjmu.edu.cn/js/jquery/jquery.min.js"></script> <script src="https://jpxb.bjmu.edu.cn/js/bootstrap/js/bootstrap.min.js"></script>   <link rel="stylesheet" href="https://jpxb.bjmu.edu.cn/js/colorbox/colorbox.css"> <script 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href="https://jpxb.bjmu.edu.cn/CN/article/showTenYearVolumnDetail.do?nian=2024">Vol. 55</a> ›› <a href="https://jpxb.bjmu.edu.cn/CN/volumn/volumn_119.shtml">Issue (5)</a>: 556-564.</span><span class="doi-doi">doi: <a href="https://doi.org/10.16098/j.issn.0529-1356.2024.05.006" target="_blank">10.16098/j.issn.0529-1356.2024.05.006</a></span> </p> <p> </p> <p class="clearfix"> <span class="pull-left">• 细胞和分子生物学 •</span> <span class="pull-right"><a href="https://jpxb.bjmu.edu.cn/CN/abstract/abstract2870.shtml"><i class="glyphicon glyphicon-chevron-left"></i> 上一篇</a>    <a href="https://jpxb.bjmu.edu.cn/CN/abstract/abstract2860.shtml">下一篇 <i class="glyphicon glyphicon-chevron-right"></i></a></span> </p>  <h3 class="abs-tit"> 当归多糖促进骨髓移植重建受体小鼠造血功能 </h3> <p data-toggle="collapse" data-target="#divPanel"> <span> 杨婷<sup>1</sup>  廖奎<sup>2</sup>  黄彩虹<sup>1</sup>  魏晗<sup>1</sup>  王程<sup>1</sup>  杜坤航<sup>1</sup> 汪子铃<sup>1</sup>  王璐<sup>1</sup>  王亚平<sup>1*</sup><br />    <span data-placement="right" type="button"> <i class="glyphicon glyphicon-menu-down" style="cursor:pointer;"></i> </span> </span> </p> <div id="divPanel" class="collapse bs-callout"> <address class="address"> <ol class="list-unstyled"> <li>1.重庆医科大学组织学与胚胎学教研室，干细胞与组织工程研究室；2.第一附属医院肿瘤科，重庆  400016</li> </ol> </address> <ul class="list-unstyled code-style" style="overflow: hidden;"> <li> <span> <code>收稿日期:</code>2024-05-28 </span> <span> <code>修回日期:</code>2024-06-09 </span> <span> </span> <span> <code>出版日期:</code>2024-10-06 </span> <span> <code>发布日期:</code>2024-10-06 </span> </li> <li> <code>通讯作者:</code> 王亚平 E-mail:ypwangcq@aliyun.com </li> <li> </li> <li> <code class="pull-left" style="overflow: hidden;">基金资助:</code><div class="pull-left">当归多糖调控Keap1-Nrf2-ARE抗氧化通路延缓造血干细胞衰老的机制研究;当归多糖通过调控网状基质细胞分泌IL-7修复化疗后Pro-B淋巴细胞的机制研究</div> </li> </ul> </div>   <h3 class="abs-tit"> <div style="text-align:justify;"> Angelica Sinensis polysaccharide promoting hematopoietic reconstruction in receptor mice after bone marrow transplantation </div> </h3> <p data-toggle="collapse" data-target="#divPanelEn"> <span> YANG  Ting<sup>1</sup>  LIAO  Kui<sup>2</sup>  HUANG  Cai-hong<sup>1</sup>  WEI  Han<sup>1</sup>  WANG  Cheng<sup>1</sup>  DU  Kun-hang<sup>1</sup>  WANG  Zi-ling<sup>1</sup>  WANG  Lu<sup>1</sup>  WANG  Ya-ping<sup>1*</sup> #br# <div> #br# </div>    <span data-placement="right" type="button"> <i class="glyphicon glyphicon-menu-down" style="cursor:pointer;"></i> </span> </span> </p> <div id="divPanelEn" class="collapse bs-callout"> <address class="address"> <ol class="list-unstyled"> <li><div style="text-align:justify;"> 1.Department of Histology and Embryology, Laboratory of Stem Cells and Tissue Engineering,Chongqing Medical University;  2.Department of Oncology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016,China </div></li> </ol> </address> <ul class="list-unstyled code-style" style="overflow: hidden;"> <li> <span> <code>Received:</code>2024-05-28 </span> <span> <code>Revised:</code>2024-06-09 </span> <span> </span> <span> <code>Online:</code>2024-10-06 </span> <span> <code>Published:</code>2024-10-06 </span> </li> <li> <code>Contact:</code> WANG Ya-ping E-mail:ypwangcq@aliyun.com </li> <li> </li> <li> </li> </ul> </div>   <div class="group clearfix"> <div class="row diyihangdg"> <div class="col-xs-6 col-sm-4 col-md-2 col-lg-2 margin-bottom-10"> <span class="change-section"> <a href="#1" onClick="lsdy1('PDF','2859','https://jpxb.bjmu.edu.cn','2024','119');return false;" class="black-bg btn-menu"> <i class="fa fa-file-pdf-o text-danger"></i> <h2>PDF</h2> <span class="badge"> <span id="mag-getXiaZaiShu-2859"></span> <script> $("#mag-getXiaZaiShu-2859").load('/CN/article/getXiaZaiShu.jsp?articleid=2859&ajax=true'); </script> </span> </a> </span> </div>  <div class="col-xs-6 col-sm-4 col-md-2 col-lg-2 margin-bottom-10" id="knowledge_map_div" style="display:none;"> <span class="change-section" onmouseover="changeKnowledgeMapImg(2)" 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style="text-align:justify;"> 目的   探讨当归多糖（ASP）调控骨髓基质细胞（BMSCs）促进供体骨髓移植（BMT）重建受体小鼠造血功能的机制。方法   分离纯化8~10周龄雄性C57BL/6J小鼠骨髓单个核细胞（BMMNCs），移植给同龄同种雌性受体小鼠，第9天取受体鼠BMMNCs，再次移植给雌性受体小鼠。移植受体鼠分为对照组：假照射；辐射组：8.0 Gy X射线全身一次性照射；骨髓移植组：照射同辐射组，经尾静脉移植雄性供体BMMNCs（5×106个细胞）；骨髓移植ASP组：同骨髓移植组，从移植的第1天起连续腹腔注射ASP［100 mg/（kg·d)×9］。模型构建期间记录小鼠体重与生存变化，模型构建结束后采集受体小鼠BMMNCs检测Y染色体性别决定区（SRY）基因，测定外周血血常规指标，计算股骨BMMNCs数，观察骨髓组织病理学；分离培养受体鼠BMSCs，观察细胞贴壁生长，5-乙炔基-2’-脱氧尿苷(EdU)法检测BMSCs增殖；分析细胞内活性氧(ROS)水平、超氧化物歧化酶(SOD)活性及丙二醛(MDA)含量；检测BMSCs培养上清液中粒细胞-巨噬细胞集落刺激因子（GM-CSF）、干细胞因子（SCF）和胰岛素样生长因子1（IGF-1）水平，检测BMMNCs与各组BMSCs共培养48h，形成造血祖细胞混合集落（CFU-Mix）数量；Real-time PCR分析受体BMMNCs的Notch信号通路相关基因（Notch1、Jagged1、Hes1）表达。结果   单纯辐射组小鼠全部死亡，骨髓移植ASP组受体鼠体重下降不明显；在受体雌鼠BMMNCs中检测到SRY基因；骨髓移植ASP组受体鼠外周血血常规和BMMNCs总数下降幅度不显著，骨髓组织病理学损伤减轻；ASP能促进BMSCs增殖，降低BMSCs中 ROS、MDA含量，提高SOD活性；促进BMSCs分泌SCF、GM-CSF及IGF-1，提高BMMNCs与受体BMSCs共培养后的CFU-Mix产率；提高受体小鼠BMMNCs中Notch1、Jagged1、Hes1 mRNA表达。结论   ASP促进受体小鼠造血功能重建机制与减轻造血微环境氧化应激损伤，提高BMSCs分泌造血生长因子，调控Notch信号通路有关。  </div></p> <form name="refForm" action="showCorrelativeArticle.do" method=post target=_blank> <input type="hidden" name="searchSQL" value="" /> <input type=hidden name="keyword" value="" id="keyword"> <input type=hidden name="author" value="" id="author"> <p><strong>关键词: </strong> <a href="#" onClick="searchKeyword('https://jpxb.bjmu.edu.cn','1','当归多糖｜X射线辐射｜骨髓移植｜造血重建｜骨髓微环境｜免疫荧光｜实时定量聚合酶链反应｜小鼠&nbsp')">当归多糖｜X射线辐射｜骨髓移植｜造血重建｜骨髓微环境｜免疫荧光｜实时定量聚合酶链反应｜小鼠&nbsp</a> </p> <p><strong>Abstract: </strong><div style="text-align:justify;"> Objective   To explore the mechanism of Angelica Sinensis polysaccharide (ASP) promoting donor bone marrow transplantation (BMT) to reconstruct hematopoietic function of receptor mice by regulating bone marrow stromalcells (BMSCs).  Methods   Bone marrow mononuclear cells (BMMNCs) of male C57BL/6J mice aged 8-10 weeks were separated, purified and transplanted into female receptor mice of the same age. On the ninth day, receptor mice BMMNCs were separated, purified and transplanted again into female receptor mice. The transplanted receptor mice were divided into control group:  sham irradiation; Irradiation(IR) group: a whole-body irradiation with a total dose of 8.0 Gy X-ray; BMT group: the receptor mice treated in the same way as the IR group and transplanted BMMNCs (5×106 cells) from male donor via the tail vein; BMT+ASP group: the receptor mice treated in the same way as the BMT group, and injected ASP ［100 mg/（kg·d）×9］ by intraperitoneal route from the first day of transplantation. Changes in body weight and survival rate of mice were recorded during modeling, receptor mice BMMNCs were collected to detect sexdetermining region of Y(SRY) gene after building model, peripheral blood indexes, the number of BMMNCs in femur and histopathology of bone marrow were detected; BMSCs in receptor mice was separated and purified, BMSCs adhesion ability was observed, proliferation ability was detected by 5-ethynyl-2-deoxyuridine(EdU);The level of reactive oxygen species (ROS), the activity of superoxide dismutase (SOD) and the content of malondialdehyde (MDA) in BMSCs were detected; The levels of granulocyte-macrophage colony-stimulating factor (GM-CSF), stem cell factor(SCF), insulinlike growth factor 1(IGF-1) in culture supernatant of BMSCs were determined, CFU-Mix was counted after BMMNCs co-cultured with receptor BMSCs in each group for 48 hours;The expression of Notch signaling pathway related genes (Notch1, Jagged1, Hes1) in BMMNCs were measured by Real-time PCR.    Results   All mice in IR group were died,the body weight loss in BMT+ASP group was not obvious. The SRY gene was detected in the receptor female mice BMMNCs. Peripheral blood indexes and the number of BMMNCs were not significantly decreased in BMT+ASP group receptor mice,and bone marrow histopathological injury was reduced. ASP promoted the proliferation of BMSCs, decreased the contents of ROS and MDA, and increased the activity of SOD in BMSCs. ASP promoted the secretion of SCF, GM-CSF and IGF-1 in BMSCs, and increased CFU-Mix yield of BMMNCs co-cultured with receptor BMSCs. ASP increased the expression of Notch1, Jagged1 and Hes1 mRNA in BMMNCs.  Conclusion   The mechanism of ASP promoting receptor hematopoietic function reconstruction is related to reducing the oxidative stress damage of hematopoietic microenvironment, improving the secretion of hematopoietic growth factors in BMSCs, and regulating Notch signaling pathway.  </div></p> <p><strong>Key words: </strong> <a href="#" onClick="searchEnKeyword('https://jpxb.bjmu.edu.cn','1','Angelica Sinensis polysaccharide｜X-ray radiation')">Angelica Sinensis polysaccharide｜X-ray radiation, </a> <a href="#" onClick="searchEnKeyword('https://jpxb.bjmu.edu.cn','1','Bone marrow transplantation｜Hematopoietic reconstruction｜Bone marrow microenvironment｜Immunofluorescence｜Real-time PCR｜Mouse')">Bone marrow transplantation｜Hematopoietic reconstruction｜Bone marrow microenvironment｜Immunofluorescence｜Real-time PCR｜Mouse</a> </p> </form>  <form name="subjectSchemeForm" action="" method=post target=_blank> <input type="hidden" name="searchSQL" /> <input type="hidden" name="language" /> </form>  <p> <strong> 中图分类号:  </strong> </p> <ul class="list-unstyled pacs"> <li> <p> <a href="#" onclick="subjectScheme('https://jpxb.bjmu.edu.cn','R285.5','1');return false;" target="_blank"> R285.5 </a> </p> </li> </ul>  <div class="row hidden-xs hidden-sm"> <div class="col-xs-12 col-sm-2 col-md-2 col-lg-2 margin-bottom-10 text-center"> <div class="text-primary btn-menu"> <h4>引用本文</h4> </div> </div> <div class="col-xs-12 col-sm-10 col-md-10 col-lg-10 margin-bottom-10"> <div class="primary-border"> <p>杨婷廖奎黄彩虹魏晗王程杜坤航汪子铃王璐王亚平. 当归多糖促进骨髓移植重建受体小鼠造血功能[J]. 解剖学报, 2024, 55(5): 556-564. </p> <p>YANG Ting LIAO Kui HUANG Cai-hong WEI Han WANG Cheng DU Kun-hang WANG Zi-ling WANG Lu WANG Ya-ping . <div style="text-align:justify;"> Angelica Sinensis polysaccharide promoting hematopoietic reconstruction in receptor mice after bone marrow transplantation </div>[J]. Acta Anatomica Sinica, 2024, 55(5): 556-564.</p> </div> </div> </div> <div class="row hidden-xs hidden-sm"> <div class="col-xs-12 col-sm-2 col-md-2 col-lg-2 margin-bottom-10 text-center"> <div class="btn-menu bs-callout-warning"> <h4>使用本文</h4> </div> </div> <div class="col-xs-12 col-sm-10 col-md-10 col-lg-10 margin-bottom-10"> <div class="primary-border"> <p> <b> <form name=mail action="https://jpxb.bjmu.edu.cn/CN/article/sendMail.jsp" method=post target=_blank> <div class="bshare-custom pull-left"><div class="bsPromo bsPromo2"></div><a title="分享到微信" class="bshare-weixin" href="javascript:void(0);"></a><a title="分享到新浪微博" class="bshare-sinaminiblog" href="javascript:void(0);"></a><a title="分享到QQ空间" class="bshare-qzone"></a><a title="分享到腾讯微博" class="bshare-qqmb"></a><a title="更多平台" class="bshare-more bshare-more-icon more-style-addthis"></a><span class="BSHARE_COUNT bshare-share-count" style="float: none;">0</span></div><script type="text/javascript" charset="utf-8" src="https://static.bshare.cn/b/buttonLite.js#style=-1&uuid=&pophcol=2&lang=zh"></script><script type="text/javascript" charset="utf-8" src="https://static.bshare.cn/b/bshareC0.js"></script>     /   <a href="#" id="collectArticle" class="shouc"></a> <span id="collectCount"></span> /   <a onclick="mail.submit()" href="javascript:void(null)" class="tuij">推荐</a> <input type="hidden" value='我在《解剖学报》上发现了关于“当归多糖促进骨髓移植重建受体小鼠造血功能”的文章，特向您推荐。请打开下面的网址：https://jpxb.bjmu.edu.cn/CN/abstract/abstract2859.shtml' name="neirong"> <input type="hidden" name="thishref" value="https://jpxb.bjmu.edu.cn/CN/abstract/abstract2859.shtml"> <input type="hidden" name="jname" value="解剖学报"> <input type="hidden" name="title" value='当归多糖促进骨髓移植重建受体小鼠造血功能'> <form> </b> </p> <p><b>导出引用管理器</b> <span class="daochu"><a href="https://jpxb.bjmu.edu.cn/CN/article/getTxtFile.do?fileType=EndNote&id=2859" id="ris_export">EndNote</a>|<a href="https://jpxb.bjmu.edu.cn/CN/article/getTxtFile.do?fileType=Ris&id=2859">Reference Manager</a>|<a href="https://jpxb.bjmu.edu.cn/CN/article/getTxtFile.do?fileType=ProCite&id=2859">ProCite</a>|<a id="bibtex_export" href="https://jpxb.bjmu.edu.cn/CN/article/getTxtFile.do?fileType=BibTeX&id=2859">BibTeX</a>|<a href="https://jpxb.bjmu.edu.cn/CN/article/getTxtFile.do?fileType=RefWorks&id=2859">RefWorks</a></span> </p> <p><strong>链接本文:</strong> <a href="https://jpxb.bjmu.edu.cn/CN/10.16098/j.issn.0529-1356.2024.05.006" class="txt_zhaiyao1">https://jpxb.bjmu.edu.cn/CN/10.16098/j.issn.0529-1356.2024.05.006</a> </p> <p> <strong> </strong>              <a href="https://jpxb.bjmu.edu.cn/CN/Y2024/V55/I5/556" class="txt_zhaiyao1"> https://jpxb.bjmu.edu.cn/CN/Y2024/V55/I5/556</a> </p> </div> </div> </div> </div> </div> </div> <div class="panel panel-default" > <div class="panel-heading" role="tab" id="cankaowenxian" onClick="xianshi(this)"> <a name="reference"></a> <h4 class="panel-title"> <a id="reference" class="collapsed" href="javascript:;"> 参考文献 </a> </h4> </div> <div id="collapseThree" class="panel-collapse collapse" role="tabpanel" aria-labelledby="headingThree" style="display: none;"> <div class="panel-body">  <table width="98%" border="0" align="center" cellpadding="0" cellspacing="8"> <tr> <td class="J_author"> <div style="text-align:justify;"> ［1］  Hong F, Chen Y, Gao H, et al.NLRP1 in bone marrow microenvironment controls hematopoietic reconstitution after transplantation［J］.Transplant CellTher,2021,27(11):908.e1-908.e11. </div> <div style="text-align:justify;"> ［2］  Zhao HY, Lyu ZS, Duan CW, et al. 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