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<span>Function</span> </div> </a> <button aria-controls="toc-Function-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Function subsection</span> </button> <ul id="toc-Function-sublist" class="vector-toc-list"> <li id="toc-Growth_hormone_release" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Growth_hormone_release"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.1</span> <span>Growth hormone release</span> </div> </a> <ul id="toc-Growth_hormone_release-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Constitutive_activity" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Constitutive_activity"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.2</span> <span>Constitutive activity</span> </div> </a> <ul id="toc-Constitutive_activity-sublist" 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class="vector-toc-text"> <span class="vector-toc-numb">3.1</span> <span>Agonists</span> </div> </a> <ul id="toc-Agonists-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Antagonists" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Antagonists"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.2</span> <span>Antagonists</span> </div> </a> <ul id="toc-Antagonists-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>References</span> </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Further_reading" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Further_reading"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Further reading</span> </div> </a> <ul id="toc-Further_reading-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-External_links" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#External_links"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>External links</span> </div> </a> <ul id="toc-External_links-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Contents" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" 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class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Grelinski_receptor" title="Grelinski receptor – Serbian" lang="sr" hreflang="sr" data-title="Grelinski receptor" data-language-autonym="Српски / srpski" data-language-local-name="Serbian" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Grelinski_receptor" title="Grelinski receptor – Serbo-Croatian" lang="sh" hreflang="sh" data-title="Grelinski receptor" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="Serbo-Croatian" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/GHSR" title="GHSR – Ukrainian" lang="uk" hreflang="uk" data-title="GHSR" data-language-autonym="Українська" data-language-local-name="Ukrainian" 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class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Protein-coding gene in the species Homo sapiens</div> <table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">GHSR</th></tr><tr><td colspan="4" style="text-align:center"></td></tr><tr><th colspan="4" style="text-align:center;background-color:#ddd">Identifiers</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/4267">GHSR</a></span>, GHDP, growth hormone secretagogue receptor gene, growth hormone secretagogue receptor</td></tr><tr><th scope="row" style="background-color:#c3fdb8">External IDs</th><td colspan="3" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/601898">601898</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:2441906">2441906</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=57161">57161</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=GHSR">GHSR</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000121853">GHSR - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_3.svg" class="mw-file-description" title="Chromosome 3 (human)"><img alt="Chromosome 3 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/3/39/Ideogram_human_chromosome_3.svg/300px-Ideogram_human_chromosome_3.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/39/Ideogram_human_chromosome_3.svg/450px-Ideogram_human_chromosome_3.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/39/Ideogram_human_chromosome_3.svg/600px-Ideogram_human_chromosome_3.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Chromosome_3_(human)" class="mw-redirect" title="Chromosome 3 (human)">Chromosome 3 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_3_ideogram.svg" class="mw-file-description" title="Chromosome 3 (human)"><img alt="Chromosome 3 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/9/94/Human_chromosome_3_ideogram.svg/300px-Human_chromosome_3_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/94/Human_chromosome_3_ideogram.svg/450px-Human_chromosome_3_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/94/Human_chromosome_3_ideogram.svg/600px-Human_chromosome_3_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 250.39017934209px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for GHSR"><img alt="Genomic location for GHSR" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 256.4px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for GHSR"><img alt="Genomic location for GHSR" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">3q26.31</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">172,443,291 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">172,448,456 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_3.svg" class="mw-file-description" title="Chromosome 3 (mouse)"><img alt="Chromosome 3 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/0/08/Ideogram_house_mouse_chromosome_3.svg/260px-Ideogram_house_mouse_chromosome_3.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/08/Ideogram_house_mouse_chromosome_3.svg/390px-Ideogram_house_mouse_chromosome_3.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/08/Ideogram_house_mouse_chromosome_3.svg/520px-Ideogram_house_mouse_chromosome_3.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks">Chromosome 3 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_3.svg" class="mw-file-description" title="Chromosome 3 (mouse)"><img alt="Chromosome 3 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/f/f2/Ideogram_of_house_mouse_chromosome_3.svg/300px-Ideogram_of_house_mouse_chromosome_3.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/f2/Ideogram_of_house_mouse_chromosome_3.svg/450px-Ideogram_of_house_mouse_chromosome_3.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/f2/Ideogram_of_house_mouse_chromosome_3.svg/600px-Ideogram_of_house_mouse_chromosome_3.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 45.010806826716px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for GHSR"><img alt="Genomic location for GHSR" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 51px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for GHSR"><img alt="Genomic location for GHSR" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">3|3 A3</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">27,425,500 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">27,432,159 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000121853">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">Pituitary Gland</li><br /><li style="line-height: 137%;">islet of Langerhans</li><br /><li style="line-height: 137%;">anterior pituitary</li><br /><li style="line-height: 137%;">buccal mucosa cell</li><br /><li style="line-height: 137%;">granulocyte</li><br /><li style="line-height: 137%;">cecum</li><br /><li style="line-height: 137%;">gonad</li><br /><li style="line-height: 137%;">appendix</li><br /><li style="line-height: 137%;">Hypothalamus</li><br /><li style="line-height: 137%;">blood</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000051136">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">median eminence</li><br /><li style="line-height: 137%;">arcuate nucleus</li><br /><li style="line-height: 137%;">facial motor nucleus</li><br /><li style="line-height: 137%;">dentate gyrus of hippocampal formation granule cell</li><br /><li style="line-height: 137%;">mammillary body</li><br /><li style="line-height: 137%;">ventral tegmental area</li><br /><li style="line-height: 137%;">primary visual cortex</li><br /><li style="line-height: 137%;">neural tube</li><br /><li style="line-height: 137%;">Medulla Oblongata</li><br /><li style="line-height: 137%;">spinal cord</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000121853">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:PBB_GE_GHSR_221360_s_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/1/11/PBB_GE_GHSR_221360_s_at_fs.png/250px-PBB_GE_GHSR_221360_s_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/11/PBB_GE_GHSR_221360_s_at_fs.png/375px-PBB_GE_GHSR_221360_s_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/11/PBB_GE_GHSR_221360_s_at_fs.png/500px-PBB_GE_GHSR_221360_s_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="http://biogps.org/gene/2693/">More reference expression data</a></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Molecular function</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042562">hormone binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/">signal transducer activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0017046">peptide hormone binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016520">growth hormone-releasing hormone receptor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001616">growth hormone secretagogue receptor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004930">G protein-coupled receptor activity</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Cellular component</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016021">integral component of membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016020">membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009986">cell surface</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043005">neuron projection</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045121">membrane raft</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005886">plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0098685">Schaffer collateral - CA1 synapse</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0098794">postsynapse</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0098978">glutamatergic synapse</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0099699">integral component of synaptic membrane</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Biological process</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032691">negative regulation of interleukin-1 beta production</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046676">negative regulation of insulin secretion</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051963">regulation of synapse assembly</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043134">regulation of hindgut contraction</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046697">decidualization</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043568">positive regulation of insulin-like growth factor receptor signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045923">positive regulation of fatty acid metabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009755">hormone-mediated signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0040018">positive regulation of multicellular organism growth</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032869">cellular response to insulin stimulus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032094">response to food</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009725">response to hormone</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008154">actin polymerization or depolymerization</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050728">negative regulation of inflammatory response</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007165">signal transduction</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032100">positive regulation of appetite</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030252">growth hormone secretion</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008343">adult feeding behavior</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060416">response to growth hormone</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1904000">positive regulation of eating behavior</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007283">spermatogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007565">female pregnancy</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007611">learning or memory</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010700">negative regulation of norepinephrine secretion</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032099">negative regulation of appetite</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032354">response to follicle-stimulating hormone</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032355">response to estradiol</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0036321">ghrelin secretion</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051969">regulation of transmission of nerve impulse</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060123">regulation of growth hormone secretion</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0071222">cellular response to lipopolysaccharide</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0071548">response to dexamethasone</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0090327">negative regulation of locomotion involved in locomotory behavior</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0097067">cellular response to thyroid hormone stimulus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1903672">positive regulation of sprouting angiogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1904008">response to monosodium glutamate</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1905333">regulation of gastric motility</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1905564">positive regulation of vascular endothelial cell proliferation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1990314">cellular response to insulin-like growth factor stimulus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:2000110">negative regulation of macrophage apoptotic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045927">positive regulation of growth</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060259">regulation of feeding behavior</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0120058">positive regulation of small intestinal transit</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1904349">positive regulation of small intestine smooth muscle contraction</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007186">G protein-coupled receptor signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0098696">regulation of neurotransmitter receptor localization to postsynaptic specialization membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0099170">postsynaptic modulation of chemical synaptic transmission</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0099175">regulation of postsynapse organization</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:#eee;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:#c3fdb8">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=2693&rn=1">2693</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=208188&rn=1">208188</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000121853;db=core">ENSG00000121853</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000051136;db=core">ENSMUSG00000051136</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q92847">Q92847</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q99P50">Q99P50</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_198407">NM_198407</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_004122">NM_004122</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_177330">NM_177330</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (protein)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_004113">NP_004113</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_940799">NP_940799</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_796304">NP_796304</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr3:172443291-172448456">Chr 3: 172.44 – 172.45 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr3:27425500-27432159">Chr 3: 27.43 – 27.43 Mb</a></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q14914301" class="extiw" title="d:Q14914301">View/Edit Human</a></td><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q14914302" class="extiw" title="d:Q14914302">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <p><b>Growth hormone secretagogue receptor</b>(GHS-R), also known as <b>ghrelin receptor</b>, is a <a href="/wiki/G_protein%E2%80%93coupled_receptor" class="mw-redirect" title="G protein–coupled receptor">G protein-coupled receptor</a> that binds growth hormone secretagogues (GHSs), such as <a href="/wiki/Ghrelin" title="Ghrelin">ghrelin</a>, the "hunger hormone".<sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Pradhan_2005_6-0" class="reference"><a href="#cite_note-Pradhan_2005-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> The role of GHS-R is thought to be in regulating energy homeostasis and body weight.<sup id="cite_ref-Pazos_2008_7-0" class="reference"><a href="#cite_note-Pazos_2008-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> In the brain, they are most highly expressed in the <a href="/wiki/Hypothalamus" title="Hypothalamus">hypothalamus</a>, specifically the <a href="/wiki/Ventromedial_nucleus_of_the_hypothalamus" title="Ventromedial nucleus of the hypothalamus">ventromedial nucleus</a> and <a href="/wiki/Arcuate_nucleus" class="mw-redirect" title="Arcuate nucleus">arcuate nucleus</a>. GSH-Rs are also expressed in other areas of the brain, including the <a href="/wiki/Ventral_tegmental_area" title="Ventral tegmental area">ventral tegmental area</a>, <a href="/wiki/Hippocampus" title="Hippocampus">hippocampus</a>, and <a href="/wiki/Substantia_nigra" title="Substantia nigra">substantia nigra</a>.<sup id="cite_ref-Andrews_2011_8-0" class="reference"><a href="#cite_note-Andrews_2011-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> Outside the central nervous system, too, GSH-Rs are also found in the <a href="/wiki/Liver" title="Liver">liver</a>, in <a href="/wiki/Skeletal_muscle" title="Skeletal muscle">skeletal muscle</a>, and even in the <a href="/wiki/Cardiomyocyte" class="mw-redirect" title="Cardiomyocyte">heart</a>.<sup id="cite_ref-Yin_2014_9-0" class="reference"><a href="#cite_note-Yin_2014-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Structure">Structure</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Growth_hormone_secretagogue_receptor&action=edit&section=1" title="Edit section: Structure"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Two identified transcript variants are expressed in several tissues and are evolutionarily conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for ghrelin; however, it may function to attenuate activity of isoform 1a.<sup id="cite_ref-entrez_10-0" class="reference"><a href="#cite_note-entrez-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p><p>GHS-R1a is a member of the <a href="/wiki/G_protein%E2%80%93coupled_receptor" class="mw-redirect" title="G protein–coupled receptor">G-protein-coupled receptor (GPCR)</a> family. Previous studies have shown that GPCRs can form <a href="/wiki/Heterodimers" class="mw-redirect" title="Heterodimers">heterodimers</a>, or functional receptor pairs with other types of G-protein coupled receptors (GPCRs). Various studies suggest that GHS-R1a specifically forms <a href="/wiki/Protein_dimer" title="Protein dimer">dimers</a> with the following hormone and neurotransmitter receptors: <a href="/wiki/Somatostatin_receptor_5" title="Somatostatin receptor 5">somatostatin receptor 5</a>,<sup id="cite_ref-Pradhan_2005_6-1" class="reference"><a href="#cite_note-Pradhan_2005-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Dopamine_receptor_D2" title="Dopamine receptor D2">dopamine receptor type 2 (DRD2)</a>,<sup id="cite_ref-Schellekens_2013_11-0" class="reference"><a href="#cite_note-Schellekens_2013-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Melanocortin_3_receptor" title="Melanocortin 3 receptor">melanocortin-3 receptor (MC3R)</a>, and <a href="/wiki/5-HT2C_receptor" title="5-HT2C receptor">serotonin receptor type 2C (5-HT<sub>2c</sub> receptor)</a>.<sup id="cite_ref-Schellekens_2013_11-1" class="reference"><a href="#cite_note-Schellekens_2013-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> See "Function" section below for details on the purported functions of these heterodimers. </p> <div class="mw-heading mw-heading2"><h2 id="Function">Function</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Growth_hormone_secretagogue_receptor&action=edit&section=2" title="Edit section: Function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Growth_hormone_release">Growth hormone release</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Growth_hormone_secretagogue_receptor&action=edit&section=3" title="Edit section: Growth hormone release"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The binding of ghrelin to GHS-R1a in pituitary cells stimulates the secretion, but not the synthesis, of <a href="/wiki/Growth_hormone" title="Growth hormone">growth hormone (GH)</a> by the <a href="/wiki/Pituitary_gland" title="Pituitary gland">pituitary gland</a>.<sup id="cite_ref-Andrews_2011_8-1" class="reference"><a href="#cite_note-Andrews_2011-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Constitutive_activity">Constitutive activity</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Growth_hormone_secretagogue_receptor&action=edit&section=4" title="Edit section: Constitutive activity"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>One important feature of GHS-R1a is that there is still some activity in the receptor even when it is not actively being stimulated. This is called <a href="/wiki/Constitutive_activity" class="mw-redirect" title="Constitutive activity">constitutive activity</a>, and it means that the receptor is always "on," unless acted on by an <a href="/wiki/Inverse_agonist" title="Inverse agonist">inverse agonist</a>. This constitutive activity seems to provide a tonic signal required for the development of normal height, probably through an effect on the GH axis.<sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> In fact, some GHS-R1a genetic variations, caused by <a href="/wiki/Single-nucleotide_polymorphism" title="Single-nucleotide polymorphism">single nucleotide polymorphisms (SNPs)</a>, have been found to be associated with hereditary obesity and others with hereditary short stature.<sup id="cite_ref-Wang_2016_15-0" class="reference"><a href="#cite_note-Wang_2016-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> It was also found that, when GHS-R1A constitutive activity was diminished, there were decreased levels of hunger-inducing hormone <a href="/wiki/Neuropeptide_Y" title="Neuropeptide Y">neuropeptide Y (NPY)</a> as well as in food intake and body weight.<sup id="cite_ref-16" class="reference"><a href="#cite_note-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Intracellular_signaling_mechanisms">Intracellular signaling mechanisms</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Growth_hormone_secretagogue_receptor&action=edit&section=5" title="Edit section: Intracellular signaling mechanisms"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>When the growth hormone secretagogue receptor is activated, a variety of different intracellular signaling cascades can result, depending on the cell type in which the receptor is expressed. These intracellular signaling cascades include <a href="/wiki/Mitogen-activated_protein_kinase" title="Mitogen-activated protein kinase">mitogen-activated protein kinase (MAPK)</a><sup id="cite_ref-Yin_2014_9-1" class="reference"><a href="#cite_note-Yin_2014-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup>), <a href="/wiki/Protein_kinase_A" title="Protein kinase A">protein kinase A (PKA)</a>,<sup id="cite_ref-Yin_2014_9-2" class="reference"><a href="#cite_note-Yin_2014-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Protein_kinase_B" title="Protein kinase B">protein kinase B (PKB)</a>, also known as <a href="/wiki/AKT" class="mw-redirect" title="AKT">AKT</a><sup id="cite_ref-Yin_2014_9-3" class="reference"><a href="#cite_note-Yin_2014-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup>), and <a href="/wiki/AMP-activated_protein_kinase" title="AMP-activated protein kinase">AMP Activated Protein Kinase (AMPK)</a> cascades.<sup id="cite_ref-Yin_2014_9-4" class="reference"><a href="#cite_note-Yin_2014-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Behavioral_reinforcement_of_food_intake">Behavioral reinforcement of food intake</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Growth_hormone_secretagogue_receptor&action=edit&section=6" title="Edit section: Behavioral reinforcement of food intake"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>It is well-characterized that activating the growth hormone secretagogue receptor with ghrelin induces an <a href="/wiki/Orexigenic" class="mw-redirect" title="Orexigenic">orexigenic</a> state, or general feeling of hunger.<sup id="cite_ref-Pradhan_2005_6-2" class="reference"><a href="#cite_note-Pradhan_2005-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> However, ghrelin may also play a role in behavioral reinforcement. Studies in animal models, found that food intake increased when ghrelin was specifically administered to just the ventral tegmental area (VTA), a brain area that uses dopamine signaling to reinforce behavior.<sup id="cite_ref-Andrews_2011_8-2" class="reference"><a href="#cite_note-Andrews_2011-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> In fact, the more ghrelin administered, the more food the rodent consumed.<sup id="cite_ref-Andrews_2011_8-3" class="reference"><a href="#cite_note-Andrews_2011-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> This is called a <a href="/wiki/Dose%E2%80%93response_relationship" title="Dose–response relationship">dose-dependent effect</a>. Building on this, it was found that there are growth hormone secretagogue receptors in the VTA and that ghrelin acts on the VTA through these receptors.<sup id="cite_ref-Andrews_2011_8-4" class="reference"><a href="#cite_note-Andrews_2011-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> Current studies, furthermore, suggest that the VTA may contain dimers of GHS-R1a and dopamine receptor type 2 (DRD2). If these two receptors do indeed form dimers, this would somehow link ghrelin signaling to dopaminergic signaling.<sup id="cite_ref-Andrews_2011_8-5" class="reference"><a href="#cite_note-Andrews_2011-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Enhancement_of_learning_and_memory">Enhancement of learning and memory</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Growth_hormone_secretagogue_receptor&action=edit&section=7" title="Edit section: Enhancement of learning and memory"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The growth hormone secretagogue receptor may also be linked to learning and memory. First of all, the receptor is found in the <a href="/wiki/Hippocampus" title="Hippocampus">hippocampus</a>, the brain region responsible for long-term memory.<sup id="cite_ref-Lutter_2009_18-0" class="reference"><a href="#cite_note-Lutter_2009-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> Second, it was found that specifically activating the receptor in just the hippocampus increased both <a href="/wiki/Long-term_potentiation" title="Long-term potentiation">long-term potentiation</a> (LTP) and <a href="/wiki/Dendritic_spine" title="Dendritic spine">dendritic spine</a> density, two cellular phenomena thought to be involved in learning.<sup id="cite_ref-Andrews_2011_8-6" class="reference"><a href="#cite_note-Andrews_2011-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> Third, short-term calorie restriction, defined as a 30% reduction in caloric intake for two weeks, which naturally increases ghrelin levels and thus activates the receptor, was found to increase both performance on <a href="/wiki/Spatial_memory" title="Spatial memory">spatial learning</a> tasks as well as <a href="/wiki/Adult_neurogenesis" title="Adult neurogenesis">neurogenesis in the adult hippocampus</a>.<sup id="cite_ref-Lutter_2009_18-1" class="reference"><a href="#cite_note-Lutter_2009-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Selective_ligands">Selective ligands</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Growth_hormone_secretagogue_receptor&action=edit&section=8" title="Edit section: Selective ligands"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>A range of selective ligands for the GHS-R receptor are now available and are being developed for several clinical applications. GHS-R agonists have appetite-stimulating and growth hormone-releasing effects, and are likely to be useful for the treatment of muscle wasting and frailty associated with old-age and degenerative diseases. On the other hand, GHS-R antagonists have <a href="/wiki/Anorectic" title="Anorectic">anorectic</a> effects and are likely to be useful for the treatment of <a href="/wiki/Obesity" title="Obesity">obesity</a>. </p> <div class="mw-heading mw-heading3"><h3 id="Agonists">Agonists</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Growth_hormone_secretagogue_receptor&action=edit&section=9" title="Edit section: Agonists"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1184024115">.mw-parser-output .div-col{margin-top:0.3em;column-width:30em}.mw-parser-output .div-col-small{font-size:90%}.mw-parser-output .div-col-rules{column-rule:1px solid #aaa}.mw-parser-output .div-col dl,.mw-parser-output .div-col ol,.mw-parser-output .div-col ul{margin-top:0}.mw-parser-output .div-col li,.mw-parser-output .div-col dd{page-break-inside:avoid;break-inside:avoid-column}</style><div class="div-col" style="column-width: 20em;"> <ul><li><a href="/wiki/Adenosine" title="Adenosine">Adenosine</a> (increases hunger-related signaling, but does not promote GH secretion) <sup id="cite_ref-KordonRobinson2012_19-0" class="reference"><a href="#cite_note-KordonRobinson2012-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup></li> <li><a href="/w/index.php?title=Alexamorelin&action=edit&redlink=1" class="new" title="Alexamorelin (page does not exist)">Alexamorelin</a></li> <li><a href="/wiki/Anamorelin" title="Anamorelin">Anamorelin</a></li> <li><a href="/wiki/Capromorelin" title="Capromorelin">Capromorelin</a></li> <li><a href="/w/index.php?title=CP-464709&action=edit&redlink=1" class="new" title="CP-464709 (page does not exist)">CP-464709</a></li> <li><a href="/w/index.php?title=Cortistatin-14&action=edit&redlink=1" class="new" title="Cortistatin-14 (page does not exist)">Cortistatin-14</a></li> <li><a href="/wiki/Examorelin" title="Examorelin">Examorelin (hexarelin)</a></li> <li><a href="/wiki/Ghrelin" title="Ghrelin">Ghrelin (lenomorelin)</a></li> <li><a href="/w/index.php?title=GHRP-1&action=edit&redlink=1" class="new" title="GHRP-1 (page does not exist)">GHRP-1</a></li> <li><a href="/w/index.php?title=GHRP-3&action=edit&redlink=1" class="new" title="GHRP-3 (page does not exist)">GHRP-3</a></li> <li><a href="/w/index.php?title=GHRP-4&action=edit&redlink=1" class="new" title="GHRP-4 (page does not exist)">GHRP-4</a></li> <li><a href="/w/index.php?title=GHRP-5&action=edit&redlink=1" class="new" title="GHRP-5 (page does not exist)">GHRP-5</a></li> <li><a href="/wiki/GHRP-6" title="GHRP-6">GHRP-6</a></li> <li><a href="/wiki/Ibutamoren" title="Ibutamoren">Ibutamoren (MK-677)</a></li> <li><a href="/wiki/Ipamorelin" title="Ipamorelin">Ipamorelin</a></li> <li><a href="/w/index.php?title=L-692,585&action=edit&redlink=1" class="new" title="L-692,585 (page does not exist)">L-692,585</a></li> <li><a href="/w/index.php?title=LY-426410&action=edit&redlink=1" class="new" title="LY-426410 (page does not exist)">LY-426410</a></li> <li><a href="/w/index.php?title=LY-444711&action=edit&redlink=1" class="new" title="LY-444711 (page does not exist)">LY-444711</a></li> <li><a href="/wiki/Macimorelin" title="Macimorelin">Macimorelin</a></li> <li><a href="/wiki/Pralmorelin" title="Pralmorelin">Pralmorelin (GHRP-2)</a></li> <li><a href="/wiki/Relamorelin" title="Relamorelin">Relamorelin</a></li> <li><a href="/wiki/SM-130,686" class="mw-redirect" title="SM-130,686">SM-130,686</a></li> <li><a href="/wiki/Tabimorelin" title="Tabimorelin">Tabimorelin</a></li> <li><a href="/wiki/Ulimorelin" title="Ulimorelin">Ulimorelin</a></li></ul> </div> <div class="mw-heading mw-heading3"><h3 id="Antagonists">Antagonists</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Growth_hormone_secretagogue_receptor&action=edit&section=10" title="Edit section: Antagonists"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/w/index.php?title=A-778,193&action=edit&redlink=1" class="new" title="A-778,193 (page does not exist)">A-778,193</a></li> <li><a href="/w/index.php?title=PF-5190457&action=edit&redlink=1" class="new" title="PF-5190457 (page does not exist)">PF-5190457</a><sup id="cite_ref-20" class="reference"><a href="#cite_note-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Growth_hormone_secretagogue_receptor&action=edit&section=11" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist reflist-columns references-column-width" style="column-width: 33em;"> <ol class="references"> <li id="cite_note-refGRCh38Ensembl-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCh38Ensembl_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000121853">GRCh38: Ensembl release 89: ENSG00000121853</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-refGRCm38Ensembl-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCm38Ensembl_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a 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a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=2693">"Human PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of 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Springer Science & Business Media. pp. 42–. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-3-642-18999-9" title="Special:BookSources/978-3-642-18999-9"><bdi>978-3-642-18999-9</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Brain+Somatic+Cross-Talk+and+the+Central+Control+of+Metabolism&rft.pages=42-&rft.pub=Springer+Science+%26+Business+Media&rft.date=2012-12-06&rft.isbn=978-3-642-18999-9&rft.aulast=Kordon&rft.aufirst=C&rft.au=Robinson%2C+I&rft.au=Hanoune%2C+J&rft.au=Dantzer%2C+R&rft_id=https%3A%2F%2Fbooks.google.com%2Fbooks%3Fid%3DMl7vCAAAQBAJ%26pg%3DPA42&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGrowth+hormone+secretagogue+receptor" class="Z3988"></span></span> </li> <li id="cite_note-20"><span class="mw-cite-backlink"><b><a href="#cite_ref-20">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBhattacharyaAndrewsBeveridgeCameron2014" class="citation journal cs1">Bhattacharya SK, Andrews K, Beveridge R, Cameron KO, Chen C, Dunn M, et al. (May 2014). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027753">"Discovery of PF-5190457, a Potent, Selective, and Orally Bioavailable Ghrelin Receptor Inverse Agonist Clinical Candidate"</a>. <i>ACS Medicinal Chemistry Letters</i>. <b>5</b> (5): 474–479. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1021%2Fml400473x">10.1021/ml400473x</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027753">4027753</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/24900864">24900864</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=ACS+Medicinal+Chemistry+Letters&rft.atitle=Discovery+of+PF-5190457%2C+a+Potent%2C+Selective%2C+and+Orally+Bioavailable+Ghrelin+Receptor+Inverse+Agonist+Clinical+Candidate&rft.volume=5&rft.issue=5&rft.pages=474-479&rft.date=2014-05&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4027753%23id-name%3DPMC&rft_id=info%3Apmid%2F24900864&rft_id=info%3Adoi%2F10.1021%2Fml400473x&rft.aulast=Bhattacharya&rft.aufirst=SK&rft.au=Andrews%2C+K&rft.au=Beveridge%2C+R&rft.au=Cameron%2C+KO&rft.au=Chen%2C+C&rft.au=Dunn%2C+M&rft.au=Fernando%2C+D&rft.au=Gao%2C+H&rft.au=Hepworth%2C+D&rft.au=Jackson%2C+VM&rft.au=Khot%2C+V&rft.au=Kong%2C+J&rft.au=Kosa%2C+RE&rft.au=Lapham%2C+K&rft.au=Loria%2C+PM&rft.au=Londregan%2C+AT&rft.au=McClure%2C+KF&rft.au=Orr%2C+ST&rft.au=Patel%2C+J&rft.au=Rose%2C+C&rft.au=Saenz%2C+J&rft.au=Stock%2C+IA&rft.au=Storer%2C+G&rft.au=VanVolkenburg%2C+M&rft.au=Vrieze%2C+D&rft.au=Wang%2C+G&rft.au=Xiao%2C+J&rft.au=Zhang%2C+Y&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4027753&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGrowth+hormone+secretagogue+receptor" class="Z3988"></span></span> </li> </ol></div> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Growth_hormone_secretagogue_receptor&action=edit&section=12" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin" style=""> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFPortelliThielemansVer_DonckLoyens2012" class="citation journal cs1">Portelli J, Thielemans L, Ver Donck L, Loyens E, Coppens J, Aourz N, et al. (July 2012). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441926">"Inactivation of the constitutively active ghrelin receptor attenuates limbic seizure activity in rodents"</a>. <i>Neurotherapeutics</i>. <b>9</b> (3): 658–672. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs13311-012-0125-x">10.1007/s13311-012-0125-x</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441926">3441926</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/22669710">22669710</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Neurotherapeutics&rft.atitle=Inactivation+of+the+constitutively+active+ghrelin+receptor+attenuates+limbic+seizure+activity+in+rodents&rft.volume=9&rft.issue=3&rft.pages=658-672&rft.date=2012-07&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3441926%23id-name%3DPMC&rft_id=info%3Apmid%2F22669710&rft_id=info%3Adoi%2F10.1007%2Fs13311-012-0125-x&rft.aulast=Portelli&rft.aufirst=J&rft.au=Thielemans%2C+L&rft.au=Ver+Donck%2C+L&rft.au=Loyens%2C+E&rft.au=Coppens%2C+J&rft.au=Aourz%2C+N&rft.au=Aerssens%2C+J&rft.au=Vermoesen%2C+K&rft.au=Clinckers%2C+R&rft.au=Schallier%2C+A&rft.au=Michotte%2C+Y&rft.au=Moechars%2C+D&rft.au=Collingridge%2C+GL&rft.au=Bortolotto%2C+ZA&rft.au=Smolders%2C+I&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3441926&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGrowth+hormone+secretagogue+receptor" class="Z3988"></span></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Growth_hormone_secretagogue_receptor&action=edit&section=13" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20150711072023/http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1335">"Ghrelin Receptor"</a>. <i>IUPHAR Database of Receptors and Ion Channels</i>. International Union of Basic and Clinical Pharmacology. Archived from <a rel="nofollow" class="external text" href="http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1335">the original</a> on 2015-07-11<span class="reference-accessdate">. Retrieved <span class="nowrap">2007-10-25</span></span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=IUPHAR+Database+of+Receptors+and+Ion+Channels&rft.atitle=Ghrelin+Receptor&rft_id=http%3A%2F%2Fwww.iuphar-db.org%2FGPCR%2FChapterMenuForward%3FchapterID%3D1335&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGrowth+hormone+secretagogue+receptor" class="Z3988"></span></li> <li><a rel="nofollow" class="external text" href="https://meshb.nlm.nih.gov/record/ui?name=growth+hormone+secretagogue+receptor">growth+hormone+secretagogue+receptor</a> at the U.S. National Library of Medicine <a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">Medical Subject Headings</a> (MeSH)</li> <li><a rel="nofollow" class="external text" href="http://www.vivo.colostate.edu/hbooks/pathphys/endocrine/gi/ghrelin.html">Ghrelin</a> <a rel="nofollow" class="external text" href="https://web.archive.org/web/20080512074634/http://www.vivo.colostate.edu/hbooks/pathphys/endocrine/gi/ghrelin.html">Archived</a> 2008-05-12 at the <a href="/wiki/Wayback_Machine" title="Wayback Machine">Wayback Machine</a> at <a href="/wiki/Colorado_State_University" title="Colorado State University">Colorado State University</a></li></ul> <p><i>This article incorporates text from the <a href="/wiki/United_States_National_Library_of_Medicine" title="United States National Library of Medicine">United States National Library of Medicine</a>, which is in the <a href="/wiki/Public_domain" title="Public domain">public domain</a>.</i> </p> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output 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ul{display:inline-block;white-space:nowrap;line-height:inherit}.mw-parser-output .navbar-brackets::before{margin-right:-0.125em;content:"[ "}.mw-parser-output .navbar-brackets::after{margin-left:-0.125em;content:" ]"}.mw-parser-output .navbar li{word-spacing:-0.125em}.mw-parser-output .navbar a>span,.mw-parser-output .navbar a>abbr{text-decoration:inherit}.mw-parser-output .navbar-mini abbr{font-variant:small-caps;border-bottom:none;text-decoration:none;cursor:inherit}.mw-parser-output .navbar-ct-full{font-size:114%;margin:0 7em}.mw-parser-output .navbar-ct-mini{font-size:114%;margin:0 4em}html.skin-theme-clientpref-night .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}@media(prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}}@media print{.mw-parser-output .navbar{display:none!important}}</style><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:G_protein-coupled_receptors" title="Template:G protein-coupled receptors"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:G_protein-coupled_receptors" title="Template talk:G protein-coupled receptors"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:G_protein-coupled_receptors" title="Special:EditPage/Template:G protein-coupled receptors"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Cell_surface_receptor:_G_protein-coupled_receptors" style="font-size:114%;margin:0 4em"><a href="/wiki/Cell_surface_receptor" title="Cell surface receptor">Cell surface receptor</a>: <a href="/wiki/G_protein-coupled_receptor" title="G protein-coupled receptor">G protein-coupled receptors</a></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Class_A:_Rhodopsin-like" style="font-size:114%;margin:0 4em"><a href="/wiki/Rhodopsin-like_receptors" title="Rhodopsin-like receptors">Class A</a>: <a href="/wiki/Rhodopsin" title="Rhodopsin">Rhodopsin</a>-like</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;"><a href="/wiki/Neurotransmitter_receptor" title="Neurotransmitter receptor">Neurotransmitter</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;"><a href="/wiki/Adrenergic_receptor" title="Adrenergic receptor">Adrenergic</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Alpha-1_adrenergic_receptor" title="Alpha-1 adrenergic receptor">α1</a> (<a href="/wiki/Alpha-1A_adrenergic_receptor" title="Alpha-1A adrenergic receptor">A</a></li> <li><a href="/wiki/Alpha-1B_adrenergic_receptor" title="Alpha-1B adrenergic receptor">B</a></li> <li><a href="/wiki/Alpha-1D_adrenergic_receptor" title="Alpha-1D adrenergic receptor">D</a>)</li> <li><a href="/wiki/Alpha-2_adrenergic_receptor" title="Alpha-2 adrenergic receptor">α2</a> (<a href="/wiki/Alpha-2A_adrenergic_receptor" title="Alpha-2A adrenergic receptor">A</a></li> <li><a href="/wiki/Alpha-2B_adrenergic_receptor" title="Alpha-2B adrenergic receptor">B</a></li> <li><a href="/wiki/Alpha-2C_adrenergic_receptor" title="Alpha-2C adrenergic receptor">C</a>)</li> <li><a href="/wiki/Beta-1_adrenergic_receptor" title="Beta-1 adrenergic receptor">β1</a></li> <li><a href="/wiki/Beta-2_adrenergic_receptor" title="Beta-2 adrenergic receptor">β2</a></li> <li><a href="/wiki/Beta-3_adrenergic_receptor" title="Beta-3 adrenergic receptor">β3</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;"><a href="/wiki/Purinergic_receptor" title="Purinergic receptor">Purinergic</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Adenosine_receptor" title="Adenosine receptor">Adenosine</a> (<a href="/wiki/Adenosine_A1_receptor" title="Adenosine A1 receptor">A1</a></li> <li><a href="/wiki/Adenosine_A2A_receptor" title="Adenosine A2A receptor">A2A</a></li> <li><a href="/wiki/Adenosine_A2B_receptor" title="Adenosine A2B receptor">A2B</a></li> <li><a href="/wiki/Adenosine_A3_receptor" title="Adenosine A3 receptor">A3</a>)</li> <li><a href="/wiki/P2Y_receptor" title="P2Y receptor">P2Y</a> (<a href="/wiki/P2RY1" title="P2RY1">1</a></li> <li><a href="/wiki/P2RY2" title="P2RY2">2</a></li> <li><a href="/wiki/P2RY4" title="P2RY4">4</a></li> <li><a href="/wiki/LPAR6" title="LPAR6">5</a></li> <li><a href="/wiki/P2RY6" title="P2RY6">6</a></li> <li><a href="/wiki/P2RY8" title="P2RY8">8</a></li> <li><a href="/wiki/GPR23" class="mw-redirect" title="GPR23">9</a></li> <li><a href="/wiki/P2RY10" title="P2RY10">10</a></li> <li><a href="/wiki/P2RY11" title="P2RY11">11</a></li> <li><a href="/wiki/P2Y12" title="P2Y12">12</a></li> <li><a href="/wiki/P2RY13" title="P2RY13">13</a></li> <li><a href="/wiki/P2RY14" title="P2RY14">14</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;"><a href="/wiki/5-HT_receptor" title="5-HT receptor">Serotonin</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>(all but <a href="/wiki/5-HT3_receptor" title="5-HT3 receptor">5-HT3</a>)</i> <a href="/wiki/5-HT1_receptor" title="5-HT1 receptor">5-HT1</a> (<a href="/wiki/5-HT1A_receptor" title="5-HT1A receptor">A</a></li> <li><a href="/wiki/5-HT1B_receptor" title="5-HT1B receptor">B</a></li> <li><a href="/wiki/5-HT1D_receptor" title="5-HT1D receptor">D</a></li> <li><a href="/wiki/5-HT1E_receptor" title="5-HT1E receptor">E</a></li> <li><a href="/wiki/5-HT1F_receptor" title="5-HT1F receptor">F</a>)</li> <li><a href="/wiki/5-HT2_receptor" title="5-HT2 receptor">5-HT2</a> (<a href="/wiki/5-HT2A_receptor" title="5-HT2A receptor">A</a></li> <li><a href="/wiki/5-HT2B_receptor" title="5-HT2B receptor">B</a></li> <li><a href="/wiki/5-HT2C_receptor" title="5-HT2C receptor">C</a>)</li> <li><i>5-HT</i> (<a href="/wiki/5-HT4_receptor" title="5-HT4 receptor">4</a></li> <li><a href="/wiki/5-HT5A_receptor" title="5-HT5A receptor">5A</a></li> <li><a href="/wiki/5-HT6_receptor" title="5-HT6 receptor">6</a></li> <li><a href="/wiki/5-HT7_receptor" title="5-HT7 receptor">7</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Muscarinic_acetylcholine_receptor" title="Muscarinic acetylcholine receptor">Acetylcholine</a> (<a href="/wiki/Muscarinic_acetylcholine_receptor_M1" title="Muscarinic acetylcholine receptor M1">M1</a></li> <li><a href="/wiki/Muscarinic_acetylcholine_receptor_M2" title="Muscarinic acetylcholine receptor M2">M2</a></li> <li><a href="/wiki/Muscarinic_acetylcholine_receptor_M3" title="Muscarinic acetylcholine receptor M3">M3</a></li> <li><a href="/wiki/Muscarinic_acetylcholine_receptor_M4" title="Muscarinic acetylcholine receptor M4">M4</a></li> <li><a href="/wiki/Muscarinic_acetylcholine_receptor_M5" title="Muscarinic acetylcholine receptor M5">M5</a>)</li> <li><a href="/wiki/Dopamine_receptor" title="Dopamine receptor">Dopamine</a> <ul><li><a href="/wiki/Dopamine_receptor_D1" title="Dopamine receptor D1">D1</a></li> <li><a href="/wiki/Dopamine_receptor_D2" title="Dopamine receptor D2">D2</a></li> <li><a href="/wiki/Dopamine_receptor_D3" title="Dopamine receptor D3">D3</a></li> <li><a href="/wiki/Dopamine_receptor_D4" title="Dopamine receptor D4">D4</a></li> <li><a href="/wiki/Dopamine_receptor_D5" title="Dopamine receptor D5">D5</a></li></ul></li> <li><a href="/wiki/GHB_receptor" title="GHB receptor">GHB receptor</a></li> <li><a href="/wiki/Histamine_receptor" title="Histamine receptor">Histamine</a> <ul><li><a href="/wiki/Histamine_H1_receptor" title="Histamine H1 receptor">H1</a></li> <li><a href="/wiki/Histamine_H2_receptor" title="Histamine H2 receptor">H2</a></li> <li><a href="/wiki/Histamine_H3_receptor" title="Histamine H3 receptor">H3</a></li> <li><a href="/wiki/Histamine_H4_receptor" title="Histamine H4 receptor">H4</a></li></ul></li> <li><a href="/wiki/Melatonin_receptor" title="Melatonin receptor">Melatonin</a> (<a href="/wiki/Melatonin_receptor_1A" title="Melatonin receptor 1A">1A</a></li> <li><a href="/wiki/Melatonin_receptor_1B" title="Melatonin receptor 1B">1B</a></li> <li><a href="/wiki/Melatonin_receptor_1C" title="Melatonin receptor 1C">1C</a>)</li> <li><a href="/wiki/Trace_amine-associated_receptor" title="Trace amine-associated receptor">TAAR</a> (<a href="/wiki/TAAR1" title="TAAR1">1</a></li> <li><a href="/wiki/TAAR2" title="TAAR2">2</a></li> <li><a href="/wiki/TAAR5" title="TAAR5">5</a></li> <li><a href="/wiki/TAAR6" title="TAAR6">6</a></li> <li><a href="/wiki/TAAR8" title="TAAR8">8</a></li> <li><a href="/wiki/TAAR9" title="TAAR9">9</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;">Metabolites and<br />signaling molecules</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;"><a href="/wiki/Eicosanoid_receptor" title="Eicosanoid receptor">Eicosanoid</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>CysLT</i> (<a href="/wiki/Cysteinyl_leukotriene_receptor_1" title="Cysteinyl leukotriene receptor 1">1</a></li> <li><a href="/wiki/Cysteinyl_leukotriene_receptor_2" title="Cysteinyl leukotriene receptor 2">2</a>)</li> <li><a href="/wiki/Leukotriene_B4" title="Leukotriene B4">LTB4</a> <ul><li><a href="/wiki/Leukotriene_B4_receptor" title="Leukotriene B4 receptor">1</a></li> <li><a href="/wiki/Leukotriene_B4_receptor_2" title="Leukotriene B4 receptor 2">2</a></li></ul></li> <li><a href="/wiki/Formyl_peptide_receptor_2" title="Formyl peptide receptor 2"> FPRL1</a></li> <li><a href="/wiki/Oxoeicosanoid_receptor_1" title="Oxoeicosanoid receptor 1">OXE</a></li> <li><a href="/wiki/Prostaglandin_receptor" title="Prostaglandin receptor">Prostaglandin</a> <ul><li><i>DP</i> (<a href="/wiki/Prostaglandin_D2_receptor" title="Prostaglandin D2 receptor">1</a></li> <li><a href="/wiki/GPR44" class="mw-redirect" title="GPR44">2</a>), <i>EP</i> (<a href="/wiki/EP1_receptor" class="mw-redirect" title="EP1 receptor">1</a></li> <li><a href="/wiki/Prostaglandin_E2_receptor" title="Prostaglandin E2 receptor">2</a></li> <li><a href="/wiki/Prostaglandin_E_receptor_3" class="mw-redirect" title="Prostaglandin E receptor 3">3</a></li> <li><a href="/wiki/EP4_receptor" class="mw-redirect" title="EP4 receptor">4</a>), <a href="/wiki/Prostaglandin_F_receptor" title="Prostaglandin F receptor">FP</a></li></ul></li> <li><a href="/wiki/Prostacyclin_receptor" title="Prostacyclin receptor">Prostacyclin</a></li> <li><a href="/wiki/Thromboxane_receptor" title="Thromboxane receptor">Thromboxane</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/G_protein-coupled_bile_acid_receptor" title="G protein-coupled bile acid receptor">Bile acid</a></li> <li><a href="/wiki/Cannabinoid_receptor" title="Cannabinoid receptor">Cannabinoid</a> (<a href="/wiki/Cannabinoid_receptor_type_1" class="mw-redirect" title="Cannabinoid receptor type 1">CB1</a></li> <li><a href="/wiki/Cannabinoid_receptor_type_2" class="mw-redirect" title="Cannabinoid receptor type 2">CB2</a>, <i>GPR</i> (<a href="/wiki/GPR18" class="mw-redirect" title="GPR18">18</a></li> <li><a href="/wiki/GPR55" title="GPR55">55</a></li> <li><a href="/wiki/GPR119" title="GPR119">119</a>))</li> <li><a href="/wiki/GPR183" title="GPR183">EBI2</a></li> <li><a href="/wiki/GPER" title="GPER">Estrogen</a></li> <li><a href="/wiki/Free_fatty_acid_receptor" title="Free fatty acid receptor">Free fatty acid</a> (<a href="/wiki/Free_fatty_acid_receptor_1" title="Free fatty acid receptor 1">1</a></li> <li><a href="/wiki/Free_fatty_acid_receptor_2" title="Free fatty acid receptor 2">2</a></li> <li><a href="/wiki/Free_fatty_acid_receptor_3" title="Free fatty acid receptor 3">3</a></li> <li><a href="/wiki/GPR42" title="GPR42">4</a>)</li> <li><a href="/wiki/Hydroxycarboxylic_acid_receptor" title="Hydroxycarboxylic acid receptor">Hydroxycarboxylic acids</a> <ul><li><a href="/wiki/Hydroxycarboxylic_acid_receptor_1" title="Hydroxycarboxylic acid receptor 1">1</a></li> <li><a href="/wiki/Hydroxycarboxylic_acid_receptor_2" title="Hydroxycarboxylic acid receptor 2">2</a></li> <li><a href="/wiki/Hydroxycarboxylic_acid_receptor_3" title="Hydroxycarboxylic acid receptor 3">3</a></li></ul></li> <li><a href="/wiki/Lysophosphatidic_acid" title="Lysophosphatidic acid">Lysophosphatidic acid</a> (<a href="/wiki/LPAR1" title="LPAR1">1</a></li> <li><a href="/wiki/LPAR2" title="LPAR2">2</a></li> <li><a href="/wiki/LPAR3" title="LPAR3">3</a></li> <li><a href="/wiki/LPAR4" title="LPAR4">4</a></li> <li><a href="/wiki/LPAR5" title="LPAR5">5</a></li> <li><a href="/wiki/LPAR6" title="LPAR6">6</a>)</li> <li><a href="/wiki/Lysophospholipid_receptor" title="Lysophospholipid receptor">Lysophospholipid</a> (<a href="/wiki/S1PR1" title="S1PR1">1</a></li> <li><a href="/wiki/LPAR1" title="LPAR1">2</a></li> <li><a href="/wiki/S1PR3" title="S1PR3">3</a></li> <li><a href="/wiki/LPAR2" title="LPAR2">4</a></li> <li><a href="/wiki/S1PR2" title="S1PR2">5</a></li> <li><a href="/wiki/S1PR4" title="S1PR4">6</a></li> <li><a href="/wiki/LPAR3" title="LPAR3">7</a></li> <li><a href="/wiki/S1PR5" title="S1PR5">8</a>)</li> <li><a href="/wiki/OXGR1" title="OXGR1">Oxoglutarate</a></li> <li><a href="/wiki/Platelet-activating_factor_receptor" title="Platelet-activating factor receptor">PAF</a></li> <li><a href="/wiki/Sphingosine-1-phosphate" title="Sphingosine-1-phosphate">Sphingosine-1-phosphate</a> (<a href="/wiki/S1PR1" title="S1PR1">1</a></li> <li><a href="/wiki/S1PR2" title="S1PR2">2</a></li> <li><a href="/wiki/S1PR3" title="S1PR3">3</a></li> <li><a href="/wiki/S1PR4" title="S1PR4">4</a></li> <li><a href="/wiki/S1PR5" title="S1PR5">5</a>)</li> <li><a href="/wiki/SUCNR1" title="SUCNR1">Succinate</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;">Peptide</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;"><a href="/wiki/GPCR_neuropeptide_receptor" title="GPCR neuropeptide receptor">Neuropeptide</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Neuropeptide_B/W_receptor" title="Neuropeptide B/W receptor">B/W</a> (<a href="/wiki/Neuropeptides_B/W_receptor_1" title="Neuropeptides B/W receptor 1">1</a></li> <li><a href="/wiki/Neuropeptides_B/W_receptor_2" title="Neuropeptides B/W receptor 2">2</a>)</li> <li><a href="/wiki/Neuropeptide_FF_receptor" title="Neuropeptide FF receptor">FF</a> (<a href="/wiki/Neuropeptide_FF_receptor_1" title="Neuropeptide FF receptor 1">1</a></li> <li><a href="/wiki/Neuropeptide_FF_receptor_2" title="Neuropeptide FF receptor 2">2</a>)</li> <li><a href="/wiki/Neuropeptide_S_receptor" title="Neuropeptide S receptor">S</a></li> <li><a href="/wiki/Neuropeptide_Y_receptor" title="Neuropeptide Y receptor">Y</a> (<a href="/wiki/Neuropeptide_Y_receptor_Y1" title="Neuropeptide Y receptor Y1">1</a></li> <li><a href="/wiki/Neuropeptide_Y_receptor_Y2" title="Neuropeptide Y receptor Y2">2</a></li> <li><a href="/wiki/Pancreatic_polypeptide_receptor_1" title="Pancreatic polypeptide receptor 1">4</a></li> <li><a href="/wiki/Neuropeptide_Y_receptor_Y5" title="Neuropeptide Y receptor Y5">5</a>)</li> <li><i>Neuromedin</i> (<a href="/wiki/Neuromedin_B_receptor" title="Neuromedin B receptor">B</a></li> <li><a href="/wiki/Neuromedin_U_receptor" title="Neuromedin U receptor">U</a> (<a href="/wiki/Neuromedin_U_receptor_1" title="Neuromedin U receptor 1">1</a></li> <li><a href="/wiki/Neuromedin_U_receptor_2" title="Neuromedin U receptor 2">2</a>))</li> <li><a href="/wiki/Neurotensin_receptor" title="Neurotensin receptor">Neurotensin</a> (<a href="/wiki/Neurotensin_receptor_1" title="Neurotensin receptor 1">1</a></li> <li><a href="/wiki/Neurotensin_receptor_2" title="Neurotensin receptor 2">2</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Anaphylatoxin_receptors" title="Anaphylatoxin receptors">Anaphylatoxin</a> (<a href="/wiki/C3a_receptor" title="C3a receptor">C3a</a></li> <li>C5a (<a href="/wiki/C5a_receptor" title="C5a receptor">1</a></li> <li><a href="/wiki/C5AR2" title="C5AR2">2</a>))</li> <li><a href="/wiki/Angiotensin_receptor" class="mw-redirect" title="Angiotensin receptor">Angiotensin</a> (<a href="/wiki/Angiotensin_II_receptor_type_1" title="Angiotensin II receptor type 1">1</a></li> <li><a href="/wiki/Angiotensin_II_receptor_type_2" title="Angiotensin II receptor type 2">2</a>)</li> <li><a href="/wiki/Apelin_receptor" title="Apelin receptor">Apelin</a></li> <li><a href="/wiki/Bombesin_receptor" title="Bombesin receptor">Bombesin</a> <ul><li><a href="/wiki/Bombesin-like_receptor_3" title="Bombesin-like receptor 3">BRS3</a></li> <li><a href="/wiki/Gastrin-releasing_peptide_receptor" title="Gastrin-releasing peptide receptor">GRPR</a></li> <li><a href="/wiki/Neuromedin_B_receptor" title="Neuromedin B receptor">NMBR</a>)</li> <li><a href="/wiki/Bradykinin_receptor" title="Bradykinin receptor">Bradykinin</a> (<a href="/wiki/Bradykinin_receptor_B1" title="Bradykinin receptor B1">B1</a></li> <li><a href="/wiki/Bradykinin_receptor_B2" title="Bradykinin receptor B2">B2</a>)</li></ul></li> <li><a href="/wiki/Chemokine_receptor" title="Chemokine receptor">Chemokine</a></li> <li><a href="/wiki/Cholecystokinin_receptor" title="Cholecystokinin receptor">Cholecystokinin</a> (<a href="/wiki/Cholecystokinin_A_receptor" title="Cholecystokinin A receptor">A</a></li> <li><a href="/wiki/Cholecystokinin_B_receptor" title="Cholecystokinin B receptor">B</a>)</li> <li><a href="/wiki/Endothelin_receptor" title="Endothelin receptor">Endothelin</a> <ul><li><a href="/wiki/Endothelin_A_receptor" title="Endothelin A receptor">A</a></li> <li><a href="/wiki/Endothelin_B_receptor" class="mw-redirect" title="Endothelin B receptor">B</a></li></ul></li> <li><a href="/wiki/Formyl_peptide_receptor" title="Formyl peptide receptor">Formyl peptide</a> (<a href="/wiki/Formyl_peptide_receptor_1" title="Formyl peptide receptor 1">1</a></li> <li><a href="/wiki/Formyl_peptide_receptor_2" title="Formyl peptide receptor 2">2</a></li> <li><a href="/wiki/Formyl_peptide_receptor_3" title="Formyl peptide receptor 3">3</a>)</li> <li><a href="/wiki/Follicle-stimulating_hormone_receptor" title="Follicle-stimulating hormone receptor">FSH</a></li> <li><a href="/wiki/Galanin_receptor" title="Galanin receptor">Galanin</a> (<a href="/wiki/Galanin_receptor_1" title="Galanin receptor 1">1</a></li> <li><a href="/wiki/Galanin_receptor_2" title="Galanin receptor 2">2</a></li> <li><a href="/wiki/Galanin_receptor_3" title="Galanin receptor 3">3</a>)</li> <li><a href="/wiki/Gonadotropin-releasing_hormone_receptor" title="Gonadotropin-releasing hormone receptor">Gonadotropin-releasing hormone</a> (<a href="/wiki/GNRHR" title="GNRHR">1</a></li> <li><a href="/wiki/GNRHR2" title="GNRHR2">2</a>)</li> <li><a class="mw-selflink selflink">Ghrelin</a></li> <li><a href="/wiki/KiSS1-derived_peptide_receptor" title="KiSS1-derived peptide receptor"> Kisspeptin</a></li> <li><a href="/wiki/Luteinizing_hormone/choriogonadotropin_receptor" title="Luteinizing hormone/choriogonadotropin receptor">Luteinizing hormone/choriogonadotropin</a></li> <li><a href="/wiki/MAS1_oncogene" title="MAS1 oncogene">MAS</a> (<a href="/wiki/MAS1" title="MAS1">1</a></li> <li><a href="/wiki/MAS1L" title="MAS1L">1L</a></li> <li><a href="/wiki/MRGPRD" title="MRGPRD">D</a></li> <li><a href="/wiki/MRGPRE" title="MRGPRE">E</a></li> <li><a href="/wiki/MRGPRF" title="MRGPRF">F</a></li> <li><a href="/wiki/MRGPRG" title="MRGPRG">G</a></li> <li><a href="/wiki/MRGPRX1" title="MRGPRX1">X1</a></li> <li><a href="/wiki/MRGPRX2" title="MRGPRX2">X2</a></li> <li><a href="/wiki/MRGPRX3" title="MRGPRX3">X3</a></li> <li><a href="/wiki/MRGPRX4" title="MRGPRX4">X4</a>)</li> <li><a href="/wiki/Melanocortin_receptor" title="Melanocortin receptor">Melanocortin</a> (<a href="/wiki/Melanocortin_1_receptor" title="Melanocortin 1 receptor">1</a></li> <li><a href="/wiki/ACTH_receptor" title="ACTH receptor">2</a></li> <li><a href="/wiki/Melanocortin_3_receptor" title="Melanocortin 3 receptor">3</a></li> <li><a href="/wiki/Melanocortin_4_receptor" title="Melanocortin 4 receptor">4</a></li> <li><a href="/wiki/Melanocortin_5_receptor" title="Melanocortin 5 receptor">5</a>)</li> <li><a href="/wiki/Melanin-concentrating_hormone_receptor" title="Melanin-concentrating hormone receptor">MCHR</a> (<a href="/wiki/Melanin-concentrating_hormone_receptor_1" title="Melanin-concentrating hormone receptor 1">1</a></li> <li><a href="/wiki/Melanin-concentrating_hormone_receptor_2" title="Melanin-concentrating hormone receptor 2">2</a>)</li> <li><a href="/wiki/Motilin_receptor" title="Motilin receptor">Motilin</a></li> <li><a href="/wiki/Opioid_receptor" title="Opioid receptor">Opioid</a> (<a href="/wiki/%CE%94-opioid_receptor" title="Δ-opioid receptor">Delta</a></li> <li><a href="/wiki/%CE%9A-opioid_receptor" title="Κ-opioid receptor">Kappa</a></li> <li><a href="/wiki/%CE%9C-opioid_receptor" title="Μ-opioid receptor">Mu</a></li> <li><a href="/wiki/Nociceptin_receptor" title="Nociceptin receptor">Nociceptin</a> & <a href="/wiki/OGFr" title="OGFr">Zeta</a>, but not <a href="/wiki/Sigma_receptor" title="Sigma receptor">Sigma</a>)</li> <li><a href="/wiki/Orexin_receptor" title="Orexin receptor">Orexin</a> (<a href="/wiki/Hypocretin_(orexin)_receptor_1" title="Hypocretin (orexin) receptor 1">1</a></li> <li><a href="/wiki/Hypocretin_(orexin)_receptor_2" title="Hypocretin (orexin) receptor 2">2</a>)</li> <li><a href="/wiki/Oxytocin_receptor" title="Oxytocin receptor">Oxytocin</a></li> <li><a href="/wiki/Prokineticin_receptor" title="Prokineticin receptor">Prokineticin</a> (<a href="/wiki/Prokineticin_receptor_1" title="Prokineticin receptor 1">1</a></li> <li><a href="/wiki/Prokineticin_receptor_2" title="Prokineticin receptor 2">2</a>)</li> <li><a href="/wiki/Prolactin-releasing_peptide_receptor" title="Prolactin-releasing peptide receptor">Prolactin-releasing peptide</a></li> <li><a href="/wiki/Relaxin_receptor" title="Relaxin receptor">Relaxin</a> (<a href="/wiki/Relaxin/insulin-like_family_peptide_receptor_1" title="Relaxin/insulin-like family peptide receptor 1">1</a></li> <li><a href="/wiki/Relaxin/insulin-like_family_peptide_receptor_2" title="Relaxin/insulin-like family peptide receptor 2">2</a></li> <li><a href="/wiki/Relaxin/insulin-like_family_peptide_receptor_3" title="Relaxin/insulin-like family peptide receptor 3">3</a></li> <li><a href="/wiki/Relaxin/insulin-like_family_peptide_receptor_4" title="Relaxin/insulin-like family peptide receptor 4">4</a>)</li> <li><a href="/wiki/Somatostatin_receptor" title="Somatostatin receptor">Somatostatin</a> (<a href="/wiki/Somatostatin_receptor_1" title="Somatostatin receptor 1">1</a></li> <li><a href="/wiki/Somatostatin_receptor_2" title="Somatostatin receptor 2">2</a></li> <li><a href="/wiki/Somatostatin_receptor_3" title="Somatostatin receptor 3">3</a></li> <li><a href="/wiki/Somatostatin_receptor_4" title="Somatostatin receptor 4">4</a></li> <li><a href="/wiki/Somatostatin_receptor_5" title="Somatostatin receptor 5">5</a>)</li> <li><a href="/wiki/Tachykinin_receptor" title="Tachykinin receptor">Tachykinin</a> (<a href="/wiki/Tachykinin_receptor_1" title="Tachykinin receptor 1">1</a></li> <li><a href="/wiki/Tachykinin_receptor_2" title="Tachykinin receptor 2">2</a></li> <li><a href="/wiki/Tachykinin_receptor_3" title="Tachykinin receptor 3">3</a>)</li> <li><a href="/wiki/Thyrotropin_receptor" title="Thyrotropin receptor">Thyrotropin</a></li> <li><a href="/wiki/Thyrotropin-releasing_hormone_receptor" title="Thyrotropin-releasing hormone receptor">Thyrotropin-releasing hormone</a></li> <li><a href="/wiki/Urotensin-II_receptor" title="Urotensin-II receptor">Urotensin-II</a></li> <li><a href="/wiki/Vasopressin_receptor" title="Vasopressin receptor">Vasopressin</a> (<a href="/wiki/Arginine_vasopressin_receptor_1A" class="mw-redirect" title="Arginine vasopressin receptor 1A">1A</a></li> <li><a href="/wiki/Arginine_vasopressin_receptor_1B" class="mw-redirect" title="Arginine vasopressin receptor 1B">1B</a></li> <li><a href="/wiki/Arginine_vasopressin_receptor_2" class="mw-redirect" title="Arginine vasopressin receptor 2">2</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;">Miscellaneous</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;"><a href="/wiki/Taste_receptor" title="Taste receptor">Taste</a>, bitter</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>TAS2R</i> <ul><li><a href="/wiki/TAS2R1" title="TAS2R1">1</a></li> <li><a href="/wiki/TAS2R3" title="TAS2R3">3</a></li> <li><a href="/wiki/TAS2R4" title="TAS2R4">4</a></li> <li><a href="/wiki/TAS2R5" title="TAS2R5">5</a></li> <li><a href="/wiki/TAS2R7" title="TAS2R7">7</a></li> <li><a href="/wiki/TAS2R8" title="TAS2R8">8</a></li> <li><a href="/wiki/TAS2R9" title="TAS2R9">9</a></li> <li><a href="/wiki/TAS2R10" title="TAS2R10">10</a></li> <li><a href="/wiki/TAS2R13" title="TAS2R13">13</a></li> <li><a href="/wiki/TAS2R14" title="TAS2R14">14</a></li> <li><a href="/wiki/TAS2R16" title="TAS2R16">16</a></li> <li><a href="/wiki/TAS2R19" title="TAS2R19">19</a></li> <li><a href="/wiki/TAS2R20" title="TAS2R20">20</a></li> <li><a href="/wiki/TAS2R30" title="TAS2R30">30</a></li> <li><a href="/wiki/TAS2R31" title="TAS2R31">31</a></li> <li><a href="/wiki/TAS2R38" title="TAS2R38">38</a></li> <li><a href="/wiki/TAS2R39" title="TAS2R39">39</a></li> <li><a href="/wiki/TAS2R40" title="TAS2R40">40</a></li> <li><a href="/wiki/TAS2R41" title="TAS2R41">41</a></li> <li><a href="/wiki/TAS2R42" title="TAS2R42">42</a></li> <li><a href="/wiki/TAS2R43" title="TAS2R43">43</a></li> <li><a href="/wiki/TAS2R45" title="TAS2R45">45</a></li> <li><a href="/wiki/TAS2R46" title="TAS2R46">46</a></li> <li><a href="/wiki/TAS2R50" title="TAS2R50">50</a></li> <li><a href="/wiki/TAS2R60" title="TAS2R60">60</a></li></ul></li> <li><a href="/wiki/Vomeronasal_receptor" title="Vomeronasal receptor">Vomeronasal receptor</a> type 1</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;"><a href="/wiki/Orphan_receptor" title="Orphan receptor">Orphan</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>GPR</i> (<a href="/wiki/GPR1" title="GPR1">1</a></li> <li><a href="/wiki/GPR3" title="GPR3">3</a></li> <li><a href="/wiki/GPR4" title="GPR4">4</a></li> <li><a href="/wiki/GPR6" title="GPR6">6</a></li> <li><a href="/wiki/GPR12" title="GPR12">12</a></li> <li><a href="/wiki/GPR15" title="GPR15">15</a></li> <li><a href="/wiki/GPR17" title="GPR17">17</a></li> <li><a href="/wiki/GPR18" class="mw-redirect" title="GPR18">18</a></li> <li><a href="/wiki/GPR19" title="GPR19">19</a></li> <li><a href="/wiki/GPR20" title="GPR20">20</a></li> <li><a href="/wiki/GPR21" title="GPR21">21</a></li> <li><a href="/wiki/GPR22" title="GPR22">22</a></li> <li><a href="/wiki/LPAR4" title="LPAR4">23</a></li> <li><a href="/wiki/GPR25" title="GPR25">25</a></li> <li><a href="/wiki/GPR26" title="GPR26">26</a></li> <li><a href="/wiki/GPR27" title="GPR27">27</a></li> <li><a href="/wiki/GPR31" title="GPR31">31</a></li> <li><a href="/wiki/GPR32" title="GPR32">32</a></li> <li><a href="/wiki/GPR33" title="GPR33">33</a></li> <li><a href="/wiki/GPR34" title="GPR34">34</a></li> <li><a href="/wiki/GPR35" title="GPR35">35</a></li> <li><a href="/wiki/GPR37" title="GPR37">37</a></li> <li><a href="/wiki/GPR39" title="GPR39">39</a></li> <li><a href="/wiki/GPR42" title="GPR42">42</a></li> <li><a href="/wiki/GPR44" class="mw-redirect" title="GPR44">44</a></li> <li><a href="/wiki/GPR45" title="GPR45">45</a></li> <li><a href="/wiki/GPR50" title="GPR50">50</a></li> <li><a href="/wiki/GPR52" title="GPR52">52</a></li> <li><a href="/wiki/GPR55" title="GPR55">55</a></li> <li><a href="/wiki/GPR61" title="GPR61">61</a></li> <li><a href="/wiki/GPR62" title="GPR62">62</a></li> <li><a href="/wiki/GPR63" title="GPR63">63</a></li> <li><a href="/wiki/GPR65" title="GPR65">65</a></li> <li><a href="/wiki/GPR68" title="GPR68">68</a></li> <li><a href="/wiki/GPR75" title="GPR75">75</a></li> <li><a href="/wiki/GPR78" title="GPR78">78</a></li> <li><a href="/wiki/GPR81" class="mw-redirect" title="GPR81">81</a></li> <li><a href="/wiki/GPR82" title="GPR82">82</a></li> <li><a href="/wiki/GPR83" title="GPR83">83</a></li> <li><a href="/wiki/GPR84" title="GPR84">84</a></li> <li><a href="/wiki/GPR85" title="GPR85">85</a></li> <li><a href="/wiki/GPR87" title="GPR87">87</a></li> <li><a href="/wiki/GPR88" title="GPR88">88</a></li> <li><a href="/wiki/LPAR5" title="LPAR5">92</a></li> <li><a href="/wiki/GPR101" title="GPR101">101</a></li> <li><a href="/wiki/Pyroglutamylated_RFamide_peptide_receptor" title="Pyroglutamylated RFamide peptide receptor">103</a></li> <li><a href="/wiki/Niacin_receptor_1" class="mw-redirect" title="Niacin receptor 1">109A</a></li> <li><a href="/wiki/Niacin_receptor_2" class="mw-redirect" title="Niacin receptor 2">109B</a></li> <li><a href="/wiki/GPR119" title="GPR119">119</a></li> <li><a href="/wiki/GPR120" class="mw-redirect" title="GPR120">120</a></li> <li><a href="/wiki/GPR132" title="GPR132">132</a></li> <li><a href="/wiki/GPR135" title="GPR135">135</a></li> <li><a href="/wiki/GPR137B" title="GPR137B">137B</a></li> <li><a href="/wiki/GPR139" title="GPR139">139</a></li> <li><a href="/wiki/GPR141" title="GPR141">141</a></li> <li><a href="/wiki/GPR142" title="GPR142">142</a></li> <li><a href="/wiki/GPR146" title="GPR146">146</a></li> <li><a href="/wiki/GPR148" title="GPR148">148</a></li> <li><a href="/wiki/GPR149" title="GPR149">149</a></li> <li><a href="/wiki/GPR150" title="GPR150">150</a></li> <li><a href="/wiki/GPR151" title="GPR151">151</a></li> <li><a href="/wiki/GPR152" title="GPR152">152</a></li> <li><a href="/wiki/GPR153" title="GPR153">153</a></li> <li><a href="/wiki/GPR160" title="GPR160">160</a></li> <li><a href="/wiki/GPR161" title="GPR161">161</a></li> <li><a href="/wiki/GPR162" title="GPR162">162</a></li> <li><a href="/wiki/GPR171" title="GPR171">171</a></li> <li><a href="/wiki/GPR173" title="GPR173">173</a></li> <li><a href="/wiki/GPR174" title="GPR174">174</a></li> <li><a href="/wiki/GPR176" title="GPR176">176</a></li> <li><a href="/wiki/GPR177" class="mw-redirect" title="GPR177">177</a></li> <li><a href="/wiki/GPR182" title="GPR182">182</a></li> <li><a href="/wiki/GPR183" title="GPR183">183</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;"><i>Other</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/GPR182" title="GPR182">Adrenomedullin</a></li> <li><a href="/wiki/Olfactory_receptor" title="Olfactory receptor">Olfactory</a></li> <li><a href="/wiki/Opsin" title="Opsin">Opsin</a> (<a href="/wiki/OPN3" title="OPN3">3</a></li> <li><a href="/wiki/Melanopsin" title="Melanopsin">4</a></li> <li><a href="/wiki/OPN5" title="OPN5">5</a></li> <li><a href="/wiki/OPN1LW" title="OPN1LW">1LW</a></li> <li><a href="/wiki/OPN1MW" title="OPN1MW">1MW</a></li> <li><a href="/wiki/OPN1SW" title="OPN1SW">1SW</a></li> <li><a href="/wiki/Retinal_G_protein_coupled_receptor" title="Retinal G protein coupled receptor">RGR</a></li> <li><a href="/wiki/RRH" title="RRH">RRH</a>)</li> <li><a href="/wiki/Protease-activated_receptor" title="Protease-activated receptor">Protease-activated</a> (<a href="/wiki/Coagulation_factor_II_receptor" class="mw-redirect" title="Coagulation factor II receptor">1</a></li> <li><a href="/wiki/Protease_activated_receptor_2" class="mw-redirect" title="Protease activated receptor 2">2</a></li> <li><a href="/wiki/F2RL2" title="F2RL2">3</a></li> <li><a href="/wiki/F2RL3" title="F2RL3">4</a>)</li> <li><a href="/wiki/Super_Conserved_Receptor_Expressed_in_Brain" title="Super Conserved Receptor Expressed in Brain">SREB</a> (<a href="/wiki/GPR27" title="GPR27">1</a></li> <li><a href="/wiki/GPR85" title="GPR85">2</a></li> <li><a href="/wiki/GPR173" title="GPR173">3</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Class_B:_Secretin-like" style="font-size:114%;margin:0 4em"><a href="/wiki/Secretin_receptor_family" title="Secretin receptor family">Class B</a>: <a href="/wiki/Secretin_receptor" title="Secretin receptor">Secretin</a>-like</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:10em;text-align:left;"><a href="/wiki/Adhesion_G_protein-coupled_receptor" title="Adhesion G protein-coupled receptor">Adhesion</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>ADGRB</i> <ul><li><a href="/wiki/Brain-specific_angiogenesis_inhibitor" title="Brain-specific angiogenesis inhibitor">Brain-specific angiogenesis inhibitor</a> <ul><li><a href="/wiki/Brain-specific_angiogenesis_inhibitor_1" title="Brain-specific angiogenesis inhibitor 1">1</a></li> <li><a href="/wiki/Brain-specific_angiogenesis_inhibitor_2" title="Brain-specific angiogenesis inhibitor 2">2</a></li> <li><a href="/wiki/Brain-specific_angiogenesis_inhibitor_3" title="Brain-specific angiogenesis inhibitor 3">3</a></li></ul></li></ul></li> <li><i>ADGRC</i> <ul><li><a href="/wiki/Flamingo_(protein)" title="Flamingo (protein)">Cadherin</a> <ul><li><a href="/wiki/CELSR1" title="CELSR1">1</a></li> <li><a href="/wiki/CELSR2" title="CELSR2">2</a></li> <li><a href="/wiki/CELSR3" title="CELSR3">3</a></li></ul></li></ul></li> <li><i>ADGRE</i> <ul><li><a href="/wiki/EGF_module-containing_mucin-like_hormone_receptor" title="EGF module-containing mucin-like hormone receptor">EMR</a> <ul><li><a href="/wiki/EMR1" title="EMR1">1</a></li> <li><a href="/wiki/EMR2" title="EMR2">2</a></li> <li><a href="/wiki/EMR3" title="EMR3">3</a></li></ul></li> <li><a href="/wiki/CD97" title="CD97">CD97</a></li></ul></li> <li><i>ADGRG</i> <ul><li><a href="/wiki/GPR56" title="GPR56">1</a></li> <li><a href="/wiki/GPR64" title="GPR64">2</a></li> <li><a href="/wiki/GPR97" title="GPR97">3</a></li> <li><a href="/wiki/GPR112" title="GPR112">4</a></li> <li><a href="/wiki/GPR114" title="GPR114">5</a></li> <li><a href="/wiki/GPR126" title="GPR126">6</a></li> <li><a href="/wiki/GPR128" title="GPR128">7</a></li></ul></li> <li><i>ADGRL</i> <ul><li><a href="/wiki/Latrophilin_receptor" class="mw-redirect" title="Latrophilin receptor">Latrophilin</a> <ul><li><a href="/wiki/Latrophilin_1" title="Latrophilin 1">1</a></li> <li><a href="/wiki/Latrophilin_2" title="Latrophilin 2">2</a></li> <li><a href="/wiki/Latrophilin_3" title="Latrophilin 3">3</a></li></ul></li> <li><a href="/wiki/ELTD1" class="mw-redirect" title="ELTD1">ELTD1</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:10em;text-align:left;"><a href="/wiki/Orphan_receptor" title="Orphan receptor">Orphan</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>GPR</i> (<a href="/wiki/GPR56" title="GPR56">56</a></li> <li><a href="/wiki/GPR64" title="GPR64">64</a></li> <li><a href="/wiki/GPR97" title="GPR97">97</a></li> <li><a href="/wiki/GPR98" title="GPR98">98</a></li> <li><a href="/wiki/GPR110" title="GPR110">110</a></li> <li><a href="/wiki/GPR111" title="GPR111">111</a></li> <li><a href="/wiki/GPR112" title="GPR112">112</a></li> <li><a href="/wiki/GPR113" title="GPR113">113</a></li> <li><a href="/wiki/GPR114" title="GPR114">114</a></li> <li><a href="/wiki/GPR115" title="GPR115">115</a></li> <li><a href="/wiki/GPR116" title="GPR116">116</a></li> <li><a href="/wiki/GPR123" title="GPR123">123</a></li> <li><a href="/wiki/GPR124" title="GPR124">124</a></li> <li><a href="/wiki/GPR125" title="GPR125">125</a></li> <li><a href="/wiki/GPR126" title="GPR126">126</a></li> <li><a href="/wiki/GPR128" title="GPR128">128</a></li> <li><a href="/wiki/GPR133" title="GPR133">133</a></li> <li><a href="/wiki/GPR143" title="GPR143">143</a></li> <li><a href="/wiki/GPR144" title="GPR144">144</a></li> <li><a href="/wiki/GPR155" title="GPR155">155</a></li> <li><a href="/wiki/GPR157" title="GPR157">157</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:10em;text-align:left;"><i>Other</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Calcitonin_receptor" title="Calcitonin receptor">Calcitonin</a></li> <li><a href="/wiki/CALCRL" title="CALCRL">CALCRL</a></li> <li><a href="/wiki/Corticotropin-releasing_hormone_receptor" title="Corticotropin-releasing hormone receptor">Corticotropin-releasing hormone</a> (<a href="/wiki/Corticotropin-releasing_hormone_receptor_1" title="Corticotropin-releasing hormone receptor 1">1</a></li> <li><a href="/wiki/Corticotropin-releasing_hormone_receptor_2" title="Corticotropin-releasing hormone receptor 2">2</a>)</li> <li><a href="/wiki/Glucagon_receptor_family" title="Glucagon receptor family">Glucagon</a> (<a href="/wiki/Glucagon_receptor" title="Glucagon receptor">GR</a></li> <li><a href="/wiki/Gastric_inhibitory_polypeptide_receptor" title="Gastric inhibitory polypeptide receptor">GIPR</a></li> <li><a href="/wiki/Glucagon-like_peptide-1_receptor" title="Glucagon-like peptide-1 receptor">GLP1R</a></li> <li><a href="/wiki/Glucagon-like_peptide-2_receptor" title="Glucagon-like peptide-2 receptor">GLP2R</a>)</li> <li><a href="/wiki/Growth-hormone-releasing_hormone_receptor" title="Growth-hormone-releasing hormone receptor">Growth-hormone-releasing hormone</a></li> <li><a href="/wiki/ADCYAP1R1" title="ADCYAP1R1">PACAPR1</a></li> <li><a href="/wiki/Orphan_receptor" title="Orphan receptor">GPR</a></li> <li><a href="/wiki/Methuselah-like_proteins" title="Methuselah-like proteins">Methuselah-like proteins</a></li> <li><a href="/wiki/Parathyroid_hormone_receptor" title="Parathyroid hormone receptor">Parathyroid hormone</a> (<a href="/wiki/Parathyroid_hormone_1_receptor" title="Parathyroid hormone 1 receptor">1</a></li> <li><a href="/wiki/Parathyroid_hormone_2_receptor" title="Parathyroid hormone 2 receptor">2</a>)</li> <li><a href="/wiki/Secretin_receptor" title="Secretin receptor">Secretin</a></li> <li><a href="/wiki/Vasoactive_intestinal_peptide_receptor" title="Vasoactive intestinal peptide receptor">Vasoactive intestinal peptide</a> (<a href="/wiki/VIPR1" title="VIPR1">1</a></li> <li><a href="/wiki/VIPR2" title="VIPR2">2</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Class_C:_Metabotropic_glutamate_/_pheromone" style="font-size:114%;margin:0 4em"><a href="/wiki/Class_C_GPCR" title="Class C GPCR">Class C</a>: <a href="/wiki/Metabotropic_receptor" title="Metabotropic receptor">Metabotropic</a> <a href="/wiki/Metabotropic_glutamate_receptor" title="Metabotropic glutamate receptor">glutamate</a> / <a href="/wiki/Pheromone" title="Pheromone">pheromone</a></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:10em;text-align:left;"><a href="/wiki/Taste_receptor" title="Taste receptor">Taste</a>, sweet</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>TAS1R</i> <ul><li><a href="/wiki/TAS1R1" title="TAS1R1">1</a></li> <li><a href="/wiki/TAS1R2" title="TAS1R2">2</a></li> <li><a href="/wiki/TAS1R3" title="TAS1R3">3</a></li></ul></li> <li><a href="/wiki/Vomeronasal_receptor" title="Vomeronasal receptor">Vomeronasal receptor</a>, type 2</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:10em;text-align:left;"><i>Other</i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Calcium-sensing_receptor" title="Calcium-sensing receptor">Calcium-sensing receptor</a></li> <li><a href="/wiki/GABA_receptor" title="GABA receptor">GABA<sub>B</sub></a> (<a href="/wiki/GABBR1" title="GABBR1">1</a></li> <li><a href="/wiki/GABBR2" title="GABBR2">2</a>)</li> <li><a href="/wiki/Glutamate_receptor" title="Glutamate receptor">Glutamate receptor</a> (<a href="/wiki/Metabotropic_glutamate_receptor" title="Metabotropic glutamate receptor">Metabotropic glutamate</a> (<a href="/wiki/Metabotropic_glutamate_receptor_1" title="Metabotropic glutamate receptor 1">1</a></li> <li><a href="/wiki/Metabotropic_glutamate_receptor_2" title="Metabotropic glutamate receptor 2">2</a></li> <li><a href="/wiki/Metabotropic_glutamate_receptor_3" title="Metabotropic glutamate receptor 3">3</a></li> <li><a href="/wiki/Metabotropic_glutamate_receptor_4" title="Metabotropic glutamate receptor 4">4</a></li> <li><a href="/wiki/Metabotropic_glutamate_receptor_5" title="Metabotropic glutamate receptor 5">5</a></li> <li><a href="/wiki/Metabotropic_glutamate_receptor_6" title="Metabotropic glutamate receptor 6">6</a></li> <li><a href="/wiki/Metabotropic_glutamate_receptor_7" title="Metabotropic glutamate receptor 7">7</a></li> <li><a href="/wiki/Metabotropic_glutamate_receptor_8" title="Metabotropic glutamate receptor 8">8</a>))</li> <li><a href="/wiki/GPRC6A" title="GPRC6A">GPRC6A</a></li> <li><a href="/wiki/Orphan_receptor" title="Orphan receptor">GPR</a> (<a href="/wiki/GPR156" title="GPR156">156</a></li> <li><a href="/wiki/GPR158" title="GPR158">158</a></li> <li><a href="/wiki/GPR179" title="GPR179">179</a>)</li> <li><a href="/wiki/Retinoic_acid-inducible_orphan_G_protein-coupled_receptor" title="Retinoic acid-inducible orphan G protein-coupled receptor">RAIG</a> (<a href="/wiki/GPRC5A" title="GPRC5A">1</a></li> <li><a href="/wiki/GPRC5B" title="GPRC5B">2</a></li> <li><a href="/wiki/GPRC5C" title="GPRC5C">3</a></li> <li><a href="/wiki/GPRC5D" title="GPRC5D">4</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Class_F:_Frizzled_&amp;_Smoothened" style="font-size:114%;margin:0 4em">Class F: <a href="/wiki/Frizzled" title="Frizzled">Frizzled</a> & <a href="/wiki/Smoothened" title="Smoothened">Smoothened</a></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:10em;text-align:left;">Frizzled</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Frizzled" title="Frizzled">Frizzled</a> (<a href="/wiki/FZD1" class="mw-redirect" title="FZD1">1</a></li> <li><a href="/wiki/FZD2" class="mw-redirect" title="FZD2">2</a></li> <li><a href="/wiki/FZD3" class="mw-redirect" title="FZD3">3</a></li> <li><a href="/wiki/FZD4" class="mw-redirect" title="FZD4">4</a></li> <li><a href="/wiki/FZD5" class="mw-redirect" title="FZD5">5</a></li> <li><a href="/wiki/FZD6" class="mw-redirect" title="FZD6">6</a></li> <li><a href="/wiki/FZD7" class="mw-redirect" title="FZD7">7</a></li> <li><a href="/wiki/FZD8" class="mw-redirect" title="FZD8">8</a></li> <li><a href="/wiki/FZD9" class="mw-redirect" title="FZD9">9</a></li> <li><a href="/wiki/FZD10" class="mw-redirect" title="FZD10">10</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:10em;text-align:left;">Smoothened</th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Smoothened" title="Smoothened">Smoothened</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="GH/IGF-1_axis_signaling_modulators" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:GH/IGF-1_axis_signaling_modulators" title="Template:GH/IGF-1 axis signaling modulators"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:GH/IGF-1_axis_signaling_modulators" title="Template talk:GH/IGF-1 axis signaling modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:GH/IGF-1_axis_signaling_modulators" title="Special:EditPage/Template:GH/IGF-1 axis signaling modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="GH/IGF-1_axis_signaling_modulators" style="font-size:114%;margin:0 4em"><a href="/wiki/Hypothalamic%E2%80%93pituitary%E2%80%93somatic_axis" class="mw-redirect" title="Hypothalamic–pituitary–somatic axis"><abbr title="Growth hormone">GH</abbr>/<abbr title="Insulin-like growth factor 1">IGF-1</abbr> axis</a> <a href="/wiki/Cell_signaling" title="Cell signaling">signaling</a> <a href="/wiki/Receptor_modulator" title="Receptor modulator">modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Growth_hormone_receptor" title="Growth hormone receptor"><abbr title="Growth hormone">GH</abbr><br /><small>(somatotropin)</small></a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Albusomatropin&action=edit&redlink=1" class="new" title="Albusomatropin (page does not exist)">Albusomatropin</a></li> <li><a href="/wiki/Bovine_somatotropin" title="Bovine somatotropin">Bovine somatotropin</a></li> <li><a href="/w/index.php?title=Efpegsomatropin&action=edit&redlink=1" class="new" title="Efpegsomatropin (page does not exist)">Efpegsomatropin</a></li> <li><a href="/w/index.php?title=Eftansomatropin_alfa&action=edit&redlink=1" class="new" title="Eftansomatropin alfa (page does not exist)">Eftansomatropin alfa</a></li> <li><a href="/wiki/Growth_hormone" title="Growth hormone">Growth hormone</a></li> <li><a href="/wiki/Human_placental_lactogen" title="Human placental lactogen">Human placental lactogen</a></li> <li><a href="/wiki/Lonapegsomatropin" title="Lonapegsomatropin">Lonapegsomatropin</a></li> <li><a href="/wiki/Placental_growth_hormone" class="mw-redirect" title="Placental growth hormone">Placental growth hormone (growth hormone variant)</a></li> <li><a href="/w/index.php?title=Somagrebove&action=edit&redlink=1" class="new" title="Somagrebove (page does not exist)">Somagrebove</a></li> <li><a href="/wiki/Somapacitan" title="Somapacitan">Somapacitan</a></li> <li><a href="/w/index.php?title=Somatosalm&action=edit&redlink=1" class="new" title="Somatosalm (page does not exist)">Somatosalm</a></li> <li><a href="/wiki/Somatotropin" class="mw-redirect" title="Somatotropin">Somatotropin</a></li> <li><a href="/w/index.php?title=Somatropin_pegol&action=edit&redlink=1" class="new" title="Somatropin pegol (page does not exist)">Somatropin pegol</a></li> <li><a href="/wiki/Somatrem" title="Somatrem">Somatrem</a></li> <li><a href="/w/index.php?title=Sometribove&action=edit&redlink=1" class="new" title="Sometribove (page does not exist)">Sometribove</a></li> <li><a href="/wiki/Somatrogon" title="Somatrogon">Somatrogon (MOD-4023; hGH-CTP)</a></li> <li><a href="/w/index.php?title=Somavaratan&action=edit&redlink=1" class="new" title="Somavaratan (page does not exist)">Somavaratan</a></li> <li><a href="/w/index.php?title=Somavubove&action=edit&redlink=1" class="new" title="Somavubove (page does not exist)">Somavubove</a></li> <li><a href="/w/index.php?title=Somidobove&action=edit&redlink=1" class="new" title="Somidobove (page does not exist)">Somidobove</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/w/index.php?title=G120K-hGH&action=edit&redlink=1" class="new" title="G120K-hGH (page does not exist)">G120K-hGH</a></li> <li><a href="/wiki/Pegvisomant" title="Pegvisomant">Pegvisomant</a></li></ul> <ul><li><i>Antisense oligonucleotides:</i> <a href="/w/index.php?title=Atesidorsen&action=edit&redlink=1" class="new" title="Atesidorsen (page does not exist)">Atesidorsen</a></li></ul> <ul><li><i>Binding proteins:</i> <a href="/wiki/Growth_hormone-binding_protein" title="Growth hormone-binding protein"><abbr title="Growth hormone-binding protein">GHBP</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Growth hormone-binding protein</span></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Somatostatin_receptor" title="Somatostatin receptor"><abbr title="Growth hormone-inhibiting hormone">GHIH</abbr><br /><small>(somatostatin)</small></a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=BIM-23052&action=edit&redlink=1" class="new" title="BIM-23052 (page does not exist)">BIM-23052</a></li> <li><a href="/w/index.php?title=CH-275&action=edit&redlink=1" class="new" title="CH-275 (page does not exist)">CH-275</a></li> <li><a href="/w/index.php?title=Cortistatin-14&action=edit&redlink=1" class="new" title="Cortistatin-14 (page does not exist)">Cortistatin-14</a></li> <li><a href="/w/index.php?title=Depreotide&action=edit&redlink=1" class="new" title="Depreotide (page does not exist)">Depreotide</a></li> <li><a href="/wiki/Edotreotide" title="Edotreotide">Edotreotide</a></li> <li><a href="/w/index.php?title=Ilatreotide&action=edit&redlink=1" class="new" title="Ilatreotide (page does not exist)">Ilatreotide</a></li> <li><a href="/w/index.php?title=L-803,087&action=edit&redlink=1" class="new" title="L-803,087 (page does not exist)">L-803,087</a></li> <li><a href="/w/index.php?title=L-817,818&action=edit&redlink=1" class="new" title="L-817,818 (page does not exist)">L-817,818</a></li> <li><a href="/wiki/Lanreotide" title="Lanreotide">Lanreotide</a></li> <li><a href="/w/index.php?title=NNC_26-9100&action=edit&redlink=1" class="new" title="NNC 26-9100 (page does not exist)">NNC 26-9100</a></li> <li><a href="/wiki/Octreotate" title="Octreotate">Octreotate</a></li> <li><a href="/wiki/Octreotide" title="Octreotide">Octreotide</a></li> <li><a href="/wiki/Pasireotide" title="Pasireotide">Pasireotide</a></li> <li><a href="/w/index.php?title=Pentetreotide&action=edit&redlink=1" class="new" title="Pentetreotide (page does not exist)">Pentetreotide</a></li> <li><a href="/w/index.php?title=RC-160&action=edit&redlink=1" class="new" title="RC-160 (page does not exist)">RC-160</a></li> <li><a href="/w/index.php?title=Seglitide&action=edit&redlink=1" class="new" title="Seglitide (page does not exist)">Seglitide</a></li> <li><a href="/wiki/Somatostatin" title="Somatostatin">Somatostatin (GHIH)</a></li> <li><a href="/w/index.php?title=Somatostatin_(1-28)&action=edit&redlink=1" class="new" title="Somatostatin (1-28) (page does not exist)">Somatostatin (1-28)</a></li> <li><a href="/w/index.php?title=SRIF-14&action=edit&redlink=1" class="new" title="SRIF-14 (page does not exist)">SRIF-14</a></li> <li><a href="/w/index.php?title=SRIF-28&action=edit&redlink=1" class="new" title="SRIF-28 (page does not exist)">SRIF-28</a></li> <li><a href="/w/index.php?title=TT-232&action=edit&redlink=1" class="new" title="TT-232 (page does not exist)">TT-232</a></li> <li><a href="/wiki/Vapreotide" title="Vapreotide">Vapreotide</a></li> <li><a href="/w/index.php?title=Veldoreotide&action=edit&redlink=1" class="new" title="Veldoreotide (page does not exist)">Veldoreotide</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/w/index.php?title=BIM-23056&action=edit&redlink=1" class="new" title="BIM-23056 (page does not exist)">BIM-23056</a></li> <li><a href="/w/index.php?title=Cyclosomatostatin&action=edit&redlink=1" class="new" title="Cyclosomatostatin (page does not exist)">Cyclosomatostatin</a></li> <li><a href="/w/index.php?title=CYN-154806&action=edit&redlink=1" class="new" title="CYN-154806 (page does not exist)">CYN-154806</a></li> <li><a href="/w/index.php?title=Satoreotide&action=edit&redlink=1" class="new" title="Satoreotide (page does not exist)">Satoreotide</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Growth-hormone-releasing_hormone_receptor" title="Growth-hormone-releasing hormone receptor"><abbr title="Growth hormone releasing hormone">GHRH</abbr><br /><small>(somatocrinin)</small></a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <i>Peptide:</i> <a href="/w/index.php?title=ALRN-5281&action=edit&redlink=1" class="new" title="ALRN-5281 (page does not exist)">ALRN-5281</a></li> <li><a href="/wiki/CJC-1295" title="CJC-1295">CJC-1295</a></li> <li><a href="/w/index.php?title=Dumorelin&action=edit&redlink=1" class="new" title="Dumorelin (page does not exist)">Dumorelin</a></li> <li><a href="/wiki/Growth-hormone-releasing_hormone" class="mw-redirect" title="Growth-hormone-releasing hormone">GHRH</a></li> <li><a href="/wiki/Modified_GRF_(1-29)" title="Modified GRF (1-29)">Modified GRF (1-29)</a></li> <li><a href="/w/index.php?title=Rismorelin&action=edit&redlink=1" class="new" title="Rismorelin (page does not exist)">Rismorelin</a></li> <li><a href="/wiki/Sermorelin" title="Sermorelin">Sermorelin</a></li> <li><a href="/wiki/Somatorelin" title="Somatorelin">Somatorelin</a></li> <li><a href="/wiki/Tesamorelin" title="Tesamorelin">Tesamorelin</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/w/index.php?title=MZ-5-156&action=edit&redlink=1" class="new" title="MZ-5-156 (page does not exist)">MZ-5-156</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a class="mw-selflink selflink"><abbr title="Growth hormone secretagogue">GHS</abbr><br /><small>(ghrelin)</small></a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <i>Peptide:</i> <a href="/w/index.php?title=Alexamorelin&action=edit&redlink=1" class="new" title="Alexamorelin (page does not exist)">Alexamorelin</a></li> <li><a href="/w/index.php?title=Cortistatin-14&action=edit&redlink=1" class="new" title="Cortistatin-14 (page does not exist)">Cortistatin-14</a></li> <li><a href="/w/index.php?title=EP-51216&action=edit&redlink=1" class="new" title="EP-51216 (page does not exist)">EP-51216</a></li> <li><a href="/wiki/Examorelin" title="Examorelin">Examorelin (hexarelin)</a></li> <li><a href="/wiki/Ghrelin" title="Ghrelin">Ghrelin</a></li> <li><a href="/w/index.php?title=GHRP-1&action=edit&redlink=1" class="new" title="GHRP-1 (page does not exist)">GHRP-1</a></li> <li><a href="/w/index.php?title=GHRP-3&action=edit&redlink=1" class="new" title="GHRP-3 (page does not exist)">GHRP-3</a></li> <li><a href="/w/index.php?title=GHRP-4&action=edit&redlink=1" class="new" title="GHRP-4 (page does not exist)">GHRP-4</a></li> <li><a href="/w/index.php?title=GHRP-5&action=edit&redlink=1" class="new" title="GHRP-5 (page does not exist)">GHRP-5</a></li> <li><a href="/wiki/GHRP-6" title="GHRP-6">GHRP-6</a></li> <li><a href="/wiki/Ipamorelin" title="Ipamorelin">Ipamorelin</a></li> <li><a href="/wiki/Lenomorelin" class="mw-redirect" title="Lenomorelin">Lenomorelin</a></li> <li><a href="/w/index.php?title=Livoletide&action=edit&redlink=1" class="new" title="Livoletide (page does not exist)">Livoletide</a></li> <li><a href="/w/index.php?title=LY-444711&action=edit&redlink=1" class="new" title="LY-444711 (page does not exist)">LY-444711</a></li> <li><a href="/wiki/Pralmorelin" title="Pralmorelin">Pralmorelin (GHRP-2)</a></li> <li><a href="/wiki/Relamorelin" title="Relamorelin">Relamorelin</a></li> <li><a href="/wiki/Tabimorelin" title="Tabimorelin">Tabimorelin</a></li> <li><a href="/wiki/Ulimorelin" title="Ulimorelin">Ulimorelin</a>; <i>Non-peptide:</i> <a href="/wiki/Adenosine" title="Adenosine">Adenosine</a></li> <li><a href="/wiki/Anamorelin" title="Anamorelin">Anamorelin</a></li> <li><a href="/wiki/Capromorelin" title="Capromorelin">Capromorelin</a></li> <li><a href="/w/index.php?title=CP-464709&action=edit&redlink=1" class="new" title="CP-464709 (page does not exist)">CP-464709</a></li> <li><a href="/wiki/Ibutamoren" title="Ibutamoren">Ibutamoren (MK-677)</a></li> <li><a href="/w/index.php?title=L-692,585&action=edit&redlink=1" class="new" title="L-692,585 (page does not exist)">L-692,585</a></li> <li><a href="/wiki/Macimorelin" title="Macimorelin">Macimorelin</a></li> <li><a href="/wiki/SM-130686" title="SM-130686">SM-130686</a>; <i>Unsorted:</i> <a href="/w/index.php?title=LY-426410&action=edit&redlink=1" class="new" title="LY-426410 (page does not exist)">LY-426410</a></li> <li><a href="/w/index.php?title=LY-444711&action=edit&redlink=1" class="new" title="LY-444711 (page does not exist)">LY-444711</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/w/index.php?title=A-778193&action=edit&redlink=1" class="new" title="A-778193 (page does not exist)">A-778193</a></li> <li><a href="/w/index.php?title=Cortistatin-8&action=edit&redlink=1" class="new" title="Cortistatin-8 (page does not exist)">Cortistatin-8</a></li> <li><a href="/w/index.php?title=(D-Lys%C2%B3)-GHRP-6&action=edit&redlink=1" class="new" title="(D-Lys³)-GHRP-6 (page does not exist)">(<small>D</small>-Lys³)-GHRP-6</a></li> <li><a href="/w/index.php?title=JMV2959&action=edit&redlink=1" class="new" title="JMV2959 (page does not exist)">JMV2959</a></li> <li><a href="/w/index.php?title=YIL-781&action=edit&redlink=1" class="new" title="YIL-781 (page does not exist)">YIL-781</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Somatomedin_receptor" title="Somatomedin receptor"><abbr title="Insulin-like growth factor 1">IGF-1</abbr><br /><small>(somatomedin)</small></a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>See <a href="/wiki/Template:Growth_factor_receptor_modulators" title="Template:Growth factor receptor modulators">here</a> instead.</li></ul> </div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?useformat=desktop&type=1x1&usesul3=0" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Retrieved from "<a dir="ltr" href="https://en.wikipedia.org/w/index.php?title=Growth_hormone_secretagogue_receptor&oldid=1231052092">https://en.wikipedia.org/w/index.php?title=Growth_hormone_secretagogue_receptor&oldid=1231052092</a>"</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Help:Category" title="Help:Category">Categories</a>: <ul><li><a href="/wiki/Category:Genes_on_human_chromosome_3" title="Category:Genes on human chromosome 3">Genes on human chromosome 3</a></li><li><a href="/wiki/Category:G_protein-coupled_receptors" title="Category:G 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