Gen-Covid • Evaluation of the influence of genetic factors on SARS-CoV-2 infection

<!DOCTYPE html> <html data-wf-page="5e95af0552d2e8343f557072" data-wf-site="5e9098b9426ccc573945525d"> <head> <meta charset="utf-8"> <title>Gen-Covid • Evaluation of the influence of genetic factors on SARS-CoV-2 infection</title> <meta content="Evaluation of the influence of genetic factors on SARS-CoV-2 infection COVID-19 infection presents different clinical phenotypes, from asymptomatic cases to severe pneumonia and multi-organic failure leading to death. The genetic variability of the host may play a main role in regulating the susceptibility and the severity of the disease, as it has been shown previously in other infectious diseases, that is, explaining the different behaviour of the same microorganism in different subjects. The experience of our group in host genomics and transcriptomics in infectious diseases leads us to hypothesize that the human host genetics may contribute to explain the differential patterns of COVID-19 in different subjects and age groups." name="description"> <meta content="Gen-Covid • Evaluation of the influence of genetic factors on SARS-CoV-2 infection" property="og:title"> <meta content="COVID-19 infection presents different clinical phenotypes, from asymptomatic cases to severe pneumonia and multi-organic failure leading to death. The genetic variability of the host may play a main role in regulating the susceptibility and the severity of the disease, as it has been shown previously in other infectious diseases, that is, explaining the different behaviour of the same microorganism in different subjects. The experience of our group in host genomics and transcriptomics in infectious diseases leads us to hypothesize that the human host genetics may contribute to explain the differential patterns of COVID-19 in different subjects and age groups." property="og:description"> <meta content="https://uploads-ssl.webflow.com/5e9098b9426ccc573945525d/5e949e7d877c874b3010a2fc_Logo_Gen-covid.svg" property="og:image"> <meta content="Gen-Covid • Evaluation of the influence of genetic factors on SARS-CoV-2 infection" property="twitter:title"> <meta content="COVID-19 infection presents different clinical phenotypes, from asymptomatic cases to severe pneumonia and multi-organic failure leading to death. The genetic variability of the host may play a main role in regulating the susceptibility and the severity of the disease, as it has been shown previously in other infectious diseases, that is, explaining the different behaviour of the same microorganism in different subjects. The experience of our group in host genomics and transcriptomics in infectious diseases leads us to hypothesize that the human host genetics may contribute to explain the differential patterns of COVID-19 in different subjects and age groups." property="twitter:description"> <meta content="https://uploads-ssl.webflow.com/5e9098b9426ccc573945525d/5e949e7d877c874b3010a2fc_Logo_Gen-covid.svg" property="twitter:image"> <meta property="og:type" content="website"> <meta content="summary_large_image" name="twitter:card"> <meta content="width=device-width, initial-scale=1" name="viewport"> <link href="css/normalize.css" rel="stylesheet" type="text/css"> <link href="css/components.css" rel="stylesheet" type="text/css"> <link href="css/gencovid.css" rel="stylesheet" type="text/css"> <script src="https://ajax.googleapis.com/ajax/libs/webfont/1.6.26/webfont.js" type="text/javascript"></script> <script type="text/javascript">WebFont.load({ google: { families: ["Droid Sans:400,700","DM 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0);-moz-transform:translate3d(0, 50PX, 0) scale3d(1, 1, 1) rotateX(0) rotateY(0) rotateZ(0) skew(0, 0);-ms-transform:translate3d(0, 50PX, 0) scale3d(1, 1, 1) rotateX(0) rotateY(0) rotateZ(0) skew(0, 0);transform:translate3d(0, 50PX, 0) scale3d(1, 1, 1) rotateX(0) rotateY(0) rotateZ(0) skew(0, 0);opacity:0" class="hero-paragraph">This study has been approved by the Ethics Committee of Galicia by fast-track procedure on March 18, 2020<br></p> <div data-w-id="27b0fa60-5623-70fc-34c2-15c71cd861b7" style="-webkit-transform:translate3d(0, 50PX, 0) scale3d(1, 1, 1) rotateX(0) rotateY(0) rotateZ(0) skew(0, 0);-moz-transform:translate3d(0, 50PX, 0) scale3d(1, 1, 1) rotateX(0) rotateY(0) rotateZ(0) skew(0, 0);-ms-transform:translate3d(0, 50PX, 0) scale3d(1, 1, 1) rotateX(0) rotateY(0) rotateZ(0) skew(0, 0);transform:translate3d(0, 50PX, 0) scale3d(1, 1, 1) rotateX(0) rotateY(0) rotateZ(0) skew(0, 0);opacity:0" class="button-wrapper"> <a href="#Resume" class="button w-button">Overview ↓</a> </div> </div> <div class="hero-image-wrap"><img src="images/Img_header.svg" alt="" class="header-image"></div> </div><img src="images/shape-5.svg" alt="" class="pattern-left"> </div> <div class="logo-section"> <div class="container-tight"> <div class="w-layout-grid logo-grid"> <div class="logo-wrap logo-grey"><img src="images/Logo_genvip.png" width="144" data-sizes="[{"max":10000,"size":"144px"}]" alt=""></div> <div class="logo-wrap logo-grey"><img src="images/logo_IDIS_2020.png" width="102" height="" data-sizes="[{"max":10000,"size":"102px"}]" alt=""></div> <div class="logo-wrap logo-grey"><img src="images/Logo_sgs_santiago.png" width="441" data-sizes="[{"max":479,"size":"94vw"},{"max":10000,"size":"441px"}]" sizes="(max-width: 479px) 94vw, 441px" srcset="images/Logo_sgs_santiago-p-500.png 500w, images/Logo_sgs_santiago-p-800.png 800w, images/Logo_sgs_santiago.png 882w" alt=""></div> </div> </div> </div> <nav id="Resume" class="content-section"> <div class="container"> <div class="w-layout-grid content-grid"> <div id="w-node-e77db9e4-a853-fb21-d2a7-ef2746af3fcd-3f557072" class="content-block"> <h2 class="content-h2">Abstract.</h2> <p class="paragraph">COVID-19 infection presents different clinical phenotypes, from asymptomatic cases to severe pneumonia and multi-organic failure leading to death.<br><br>The genetic variability of the host may play a main role in regulating the susceptibility and the severity of the disease, as it has been shown previously in other infectious diseases, that is, explaining the different behaviour of the same microorganism in different subjects. <a href="https://orcid.org/0000-0002-9023-581X" target="_blank">The experience of our group in host genomics and transcriptomics in infectious diseases</a> leads us to hypothesize that the human host genetics may contribute to explain the differential patterns of COVID-19 in different subjects and age groups.<br><br>For this, we will use parallel sequencing technologies (NGS), which allow the identification of rare variants that cannot be captured with the genome-wide association studies (GWAS). Furthermore, the transcriptomic approach will allow us to identify specific gene expression patterns of the host response to COVID-19 infection, as well as the identification of host expression factors that explain differential phenotypes and clinical courses.<br><br>The different behaviour of COVID-19 in paediatric patients compared to adults may reveal important clues regarding the pathogenic mechanisms of COVID-19. Data known to date suggests that paediatric susceptibility is similar to that of adults, with an attack rate of around 15%, which reinforces the hypothesis that age-driven host factors may have a differential impact on the clinical course of the disease.</p> <h3><strong>Principal investigators and sponsors: </strong></h3> <h4>Prof. Dr. F. Martinón-Torres</h4> <p class="p4">Coordinator and Head of Paediatrics, Hospital Clínico Universitario de Santiago de Compostela, Servizo Galego de Saúde. Coordinator of the Genetics, Vaccines, Infectious Diseases and Pediatrics research group (GENVIP). Institute of Healthcare Research from Santiago de Compostela , University of Santiago de Compostela.<br>ORCID: <a href="http://orcid.org/0000-0002-9023-581X" target="_blank">http://orcid.org/0000-0002-9023-581X<br></a>Web: <a href="http://www.serviciodepediatriasantiago.es" target="_blank">www.serviciodepediatriasantiago.es</a> / <a href="http://www.genvip.org" target="_blank">www.genvip.org</a><br>Twitter: <a href="https://twitter.com/fedemartinon" target="_blank">@fedemartinon</a> </p> <h4>Prof. Dr. Antonio Salas Ellacuariaga</h4> <p class="p4">Professor in the Medicine Faculty of the Universidad de Santiago de Compostela (USC).<br>Coordinator of the de Population Genetics research group (GenPoB). Institute of Healthcare Research from Santiago de Compostela , University of Santiago de Compostela<br>and co-PI in GenViP group.<br>ORCID: <a href="https://orcid.org/0000-0002-2336-702X" target="_blank">https://orcid.org/0000-0002-2336-702X</a><br>Twitter: <a href="https://twitter.com/AntonioSalasEl1" target="_blank">@AntonioSalasEl1</a> </p> </div> <div id="w-node-e77db9e4-a853-fb21-d2a7-ef2746af3fcb-3f557072" class="image-wrapper-right"><img src="images/Img_resume.svg" alt="" class="content-image"></div> </div> </div> </nav> <div id="Targets" class="content-section bg-gradient"> <div class="container"> <div class="title-wrap title-padding"> <h2>Objetives.</h2> <p class="p1">This study has the following main objectives</p> </div> <div class="w-layout-grid feature-grid"> <div class="feature-block"> <div class="icon-block icon-block-space"><img src="images/Img_objetives_identify.svg" alt=""></div> <h4>Identify</h4> <p><strong>Genetic </strong>markers of susceptibility and prognosis of COVID-19 infection</p> </div> <div id="w-node-_45f748af-3c16-92be-1d07-06a8dd2461bf-3f557072" class="feature-block"> <div class="icon-block icon-block-space"><img src="images/Img_objetives_identify.svg" alt=""></div> <h4>Identify</h4> <p><strong>Local and systemic transcriptomic signatures </strong>that allow the accurate differential diagnosis of COVID-19 infection at different timepoints of infection, as well as establish prognostic markers for its natural history</p> </div> <div class="feature-block"> <div class="icon-block icon-block-space"><img src="images/Img_objetives_study.svg" alt=""></div> <h4>Study</h4> <p>Differential expression patterns in different host samples</p> </div> <div class="feature-block"> <div class="icon-block icon-block-space"><img src="images/Img_objetives_identify.svg" alt=""></div> <h4>Identify</h4> <p><strong>Soluble biomarkers </strong>related to the immune system that allow us to characterize and predict<strong> the immune response to COVID-19</strong></p> </div> <div class="feature-block"> <div class="icon-block icon-block-space"><img src="images/Img_objetives_study.svg" alt=""></div> <h4>Study</h4> <p>Proteomic patterns in different host samples and at different stages of the infection</p> </div> <div class="feature-block"> <div class="icon-block icon-block-space"><img src="images/Img_objetives_identify.svg" alt=""></div> <h4>Study</h4> <p>Pathogen genetic variability</p> </div> <div class="feature-block"> <div class="icon-block icon-block-space"><img src="images/Img_objetives_study.svg" alt=""></div> <h4>Analysis</h4> <p><strong>Análisis multiómico</strong> de eventos Multi-omic analysis of vaccine adverse events (adversomics) and vaccine failure</p> </div> </div> </div> </div> <div id="Integration" class="content-section bg-gradient"> <div class="container"> <div class="content-block"> <h2 class="content-h2">GEN-COVID national and international integration.</h2> </div> <div class="w-layout-grid content-grid grid-integration"> <div id="w-node-d3a66892-5e4c-16c3-7341-b5fe9112623a-3f557072" class="content-block content-integration"> <div class="integration-image-wrap"><img src="images/Img_national.png" width="554" data-sizes="[{"max":589,"size":"94vw"},{"max":10000,"size":"554px"}]" sizes="(max-width: 589px) 94vw, 554px" srcset="images/Img_national-p-500.png 500w, images/Img_national.png 554w" alt=""></div> <div class="feature-wrap"><img src="images/Icon_national.svg" alt="" class="feature-icon"> <div class="feature-content-wrap"> <h4>At the national level</h4> <p class="p3">GEN-COVID will receive samples for genetic studies from the <a href="http://www.gendres.org" target="_blank">GENDRES network</a>, the EPICAL national multicenter project (coordinated by Dr. Tagarro, Hospital 12 de Octubre) and from the GESNEO-COVID national multicenter project (coordinated by Dra. Marisa Navarro, Hospital Gregorio Marañón).</p> </div> </div> </div> <div id="w-node-_290e647b-b0f7-b34d-8252-95d7d6426eb9-3f557072" class="content-block content-integration"> <div class="integration-image-wrap int-img-small"><img src="images/Img_international.png" width="316" data-sizes="[{"max":479,"size":"75vw"},{"max":10000,"size":"316px"}]" alt=""></div> <div class="feature-wrap"><img src="images/Icon_international.svg" alt="" class="feature-icon"> <div class="feature-content-wrap"> <h4>At the international level</h4> <p class="p3">We are working as part of the <a href="https://www.covid19hg.org" target="_blank">COVID-19 Host Genetics Initiative</a> on high-throughput genotyping and massive parallell sequencing projects to investigate on the host genetics factors influencing susceptibility to <a href="https://www.covid19hg.org" target="_blank">COVID-19.</a> </p> <p class="p3">GEN-COVID has cross-collaboration with other international consortiums related to COVID-19 and whose clinical coordination is carried out by the Galician Health Service (SERGAS) through the Pediatric Service of the University Clinical Hospital of Santiago, mainly through macro projects of European funding <strong>focused on the study of infections from the host's perceptive, specifically through the application of genomics, transcriptomics and proteomics to find diagnostic biomarkers related to infection.</strong></p> <ol role="list"> <li> <p class="p3"><strong>EUROPEAN PROJECT H2020 PERFORM (Grant Agreement 668303). </strong></p> </li> <li> <p class="p3"><strong>EUROPEAN PROJECT H2020 DIAMONDS (Grant Agreement 848196).</strong></p> </li> <li> <p class="p3"><strong>EUROPEAN PROJECT FP7 PREPARE (Grant Agreement 602525).</strong></p> </li> </ol> </div> </div> </div> </div> </div> </div> <div class="content-section cs-highlight wf-section"> <div class="content-block"></div> <div class="container"> <div class="content-block"> <h2 id="Publicaciones" class="content-h2">Publications.</h2> </div> <div class="w-layout-grid content-grid cg-publications"> <div id="w-node-_2a9e0a0b-7b75-4c8e-5318-05ec4879229c-3f557072" class="content-block cb-publicaciones"> <h4> <a href="https://covid19.elsevierpure.com/ca/publications/a-strategy-targeting-monocyte-macrophage-differentiation-to-avoid" target="_blank">A Strategy Targeting Monocyte-Macrophage Differentiation to Avoid Pulmonary Complications in SARS-Cov2 Infection</a> </h4> <p class="p3">J Gómez-Rial <span class="superscript">1</span>, F Martinón-Torres <span class="superscript">2</span></p> <p class="p4"><strong>Clin Immunol. 2020 Jul;216:108442. doi: 10.1016/j.clim.2020.108442. Epub 2020 Apr 23.</strong><br></p> <p class="p4">PMID: 32335290 PMCID: PMC7194539 DOI: 10.1016/j.clim.2020.108442<br></p> <a href="https://covid19.elsevierpure.com/ca/publications/a-strategy-targeting-monocyte-macrophage-differentiation-to-avoid" target="_blank" class="button-outline bo-small w-button">Access</a> </div> <div id="w-node-_2a9e0a0b-7b75-4c8e-5318-05ec487922b0-3f557072" class="content-block cb-publicaciones"> <h4> <a href="https://www.frontiersin.org/articles/10.3389/fimmu.2020.560381/full" target="_blank">Increased Serum Levels of sCD14 and sCD163 Indicate a Preponderant Role for Monocytes in COVID-19 Immunopathology<br></a> </h4> <p class="p3">Jose Gómez-Rial, Maria José Currás-Tuala, Irene Rivero-Calle, Alberto Gómez-Carballa, Miriam Cebey-López, Carmen Rodríguez-Tenreiro, Ana Dacosta-Urbieta, Carmen Rivero-Velasco, Nuria Rodríguez-Núñez, Rocio Trastoy-Pena, Javier Rodríguez-García, Antonio Salas, and Federico Martinón-Torres</p> <p class="p4"><strong>Front Immunol. 2020 Sep 23;11:560381. doi: 10.3389/fimmu.2020.560381. eCollection 2020</strong><br></p> <p class="p4">PMID: 33072099 PMCID: PMC7538662 DOI: 10.3389/fimmu.2020.560381<br></p> <a href="https://www.frontiersin.org/articles/10.3389/fimmu.2020.560381/full" target="_blank" class="button-outline bo-small w-button">Access</a> </div> <div id="w-node-_2a9e0a0b-7b75-4c8e-5318-05ec487922c0-3f557072" class="content-block cb-publicaciones"> <h4> <a href="https://www.frontiersin.org/articles/10.3389/fped.2020.00547/full">Seroprevalence of SARS-CoV-2 among pediatric healthcare workers in Spain</a> </h4> <p class="p3">A Dacosta Urbieta, I Rivero Calle, J Pardo Seco, L Redondo Collazo, A Salas J Gómez Rial and F Martinón Torres</p> <p class="p4"><strong>Front Pediatr. 2020 Sep 11;8:547. doi: 10.3389/fped.2020.00547. eCollection 2020.</strong><br></p> <p class="p4">PMID: 33042908 PMCID: PMC7516980 DOI: 10.3389/fped.2020.00547<br></p> <a href="https://www.frontiersin.org/articles/10.3389/fped.2020.00547/full" target="_blank" class="button-outline bo-small w-button">Access</a> </div> <div id="w-node-_2a9e0a0b-7b75-4c8e-5318-05ec487922cf-3f557072" class="content-block cb-publicaciones"> <h4 class="h4-dark"> <a href="https://www.dovepress.com/role-of-monocytesmacrophages-in-covid-19-pathogenesis-implications-for-peer-reviewed-article-IDR" target="_blank">Role of Monocytes/Macrophages in Covid-19 Pathogenesis: Implications for Therapy<br></a> </h4> <p class="p3">Gómez-Rial J, Rivero-Calle I, Salas A, Martinón-Torres F</p> <p class="p4"><strong>Infect Drug Resist . 2020 Jul 22;13:2485-2493. doi: 10.2147/IDR.S258639. eCollection 2020</strong><br></p> <p class="p4">PMID: 32801787 PMCID: PMC7383015 DOI: 10.2147/IDR.S258639<br></p> <a href="https://www.dovepress.com/role-of-monocytesmacrophages-in-covid-19-pathogenesis-implications-for-peer-reviewed-article-IDR" target="_blank" class="button-outline bo-small w-button">Access</a> </div> <div id="w-node-_2a9e0a0b-7b75-4c8e-5318-05ec487922df-3f557072" class="content-block cb-publicaciones"> <h4> <a href="https://genome.cshlp.org/content/early/2020/09/01/gr.266221.120" target="_blank">Mapping genome variation of SARS-CoV-2 worldwide highlights the impact of COVID-19 super-spreaders<br></a> </h4> <p class="p3">Alberto Gomez-Carballa, Xabi Bello, Jacobo Pardo-Seco, Federico Martinon-Torres and Antonio Salas<br></p> <p class="p4"><strong>Genome Res. 2020 Oct;30(10):1434-1448. doi: 10.1101/gr.266221.120. Epub 2020 Sep 2.</strong><br></p> <p class="p4">PMID: 32878977 PMCID: PMC7605265 (available on 2021-04-01) DOI: 10.1101/gr.266221.120<br></p> <a href="https://genome.cshlp.org/content/early/2020/09/01/gr.266221.120" target="_blank" class="button-outline bo-small w-button">Access</a> </div> <div id="w-node-_2a9e0a0b-7b75-4c8e-5318-05ec487922f0-3f557072" class="content-block cb-publicaciones"> <h4> <a href="http://www.zoores.ac.cn/en/article/doi/10.24272/j.issn.2095-8137.2020.217" target="_blank"><strong>Phylogeography of SARS-CoV-2 pandemic in Spain: a story of multiple introductions, micro-geographic stratification, founder effects, and super-spreaders<br></strong></a> </h4> <p class="p3">Alberto Gómez-Carballa, Xabier Bello, Jacobo Pardo-Seco, María Luisa Pérez Del Molino Federico Martinón-Torres, Antonio Salas<br></p> <p class="p4"><strong>Zool Res. 2020 Nov 18;41(6):605-620. doi: 10.24272/j.issn.2095-8137.2020.217.</strong><br></p> <p class="p4">PMID: 32935498 PMCID: PMC7671907 DOI: 10.24272/j.issn.2095-8137.2020.217<br></p> <a href="http://www.zoores.ac.cn/en/article/doi/10.24272/j.issn.2095-8137.2020.217" target="_blank" class="button-outline bo-small w-button">Access</a> </div> <div id="w-node-_2a9e0a0b-7b75-4c8e-5318-05ec48792302-3f557072" class="content-block cb-publicaciones"> <h4> <a href="http://www.zoores.ac.cn/article/doi/10.24272/j.issn.2095-8137.2020.364" target="_blank"><strong>Pitfalls of barcodes in the study of worldwide SARS-CoV-2 variation and phylodynamics.</strong></a> </h4> <p class="p3">Pardo-Seco J, Gómez-Carballa A, Bello X, Martinón-Torres F, Salas A.<br></p> <p class="p4"><strong>Zool Res. 2021 Jan 18;42(1):87-93. doi: 10.24272/j.issn.2095-8137.2020.364.</strong><br></p> <p class="p4">PMID: 33410308.<br></p> <a href="http://www.zoores.ac.cn/article/doi/10.24272/j.issn.2095-8137.2020.364" target="_blank" class="button-outline bo-small w-button">Access</a> </div> <div id="w-node-d03c88d8-11d4-7406-d916-d4d41ebbec31-3f557072" class="content-block cb-publicaciones"> <h4> <a href="https://science.sciencemag.org/content/early/2020/12/09/science.abe3261/tab-e-letters" target="_blank"><strong>Phylogenetic analysis of SARS-CoV-2 in Boston highlights the impact of superspreading events</strong></a> </h4> <p class="p3">Salas A, Bello X, Pardo-Seco J, Martinón-Torres F, Gómez-Carballa<br></p> <p class="p4"><strong>A (2021) Superspreading: The engine of the SARS-CoV-2 pandemic. Science, eLetter;</strong><br></p> <a href="https://science.sciencemag.org/content/early/2020/12/09/science.abe3261/tab-e-letters" target="_blank" class="button-outline bo-small w-button">Access</a> </div> <div id="w-node-dd3de8ca-4a40-ed78-b9c0-b25b6ad74abc-3f557072" class="content-block cb-publicaciones"> <h4> <a href="https://pubmed.ncbi.nlm.nih.gov/35202626/" target="_blank"><strong>A multi-tissue study of immune gene expression profiling highlights the key role of the nasal epithelium in COVID-19 severity</strong></a> </h4> <p class="p3">Alberto Gómez-Carballa , Irene Rivero-Calle, Jacobo Pardo-Seco, José Gómez-Rial, Carmen Rivero-Velasco, Nuria Rodríguez-Núñez, Gema Barbeito-Castiñeiras, Hugo Pérez-Freixo, Miriam Cebey-López, Ruth Barral-Arca, Carmen Rodriguez-Tenreiro, Ana Dacosta-Urbieta, Xabier Bello, Sara Pischedda, María José Currás-Tuala, Sandra Viz-Lasheras, Federico Martinón-Torres, Antonio Salas, GEN-COVID study group<br></p> <p class="p4"><strong>Environ Res</strong><strong>. 2022 Feb 22;210:112890. doi: 10.1016/j.envres.2022.112890</strong><br></p> <p class="p4">PMID: 35202626 PMCID: PMC8861187 DOI: 10.1016/j.envres.2022.112890<br></p> <a href="https://pubmed.ncbi.nlm.nih.gov/35202626/" target="_blank" class="button-outline bo-small w-button">Access</a> </div> </div> <div class="content-block"> <h2 id="Publicaciones" class="content-h2">Achievements.</h2> </div> <div class="w-layout-grid content-grid cg-publications"> <div id="w-node-_28101512-4cbf-a849-2609-6cc940e65cc7-3f557072" class="content-block cb-publicaciones cb-logros"> <h5>Project granted by the GAIN entity: Galician Innovation Agency</h5> <p class="p3">GaIN Rescata-Covid_IN845D 2020/23 projects</p> <h4 class="title-grey">Evaluation of the influence of host genetic factors on susceptibility, pathogenesis, diagnosis and prognosis in infection by SARS-COV-2 (GEN-COVID)</h4> </div> <div id="w-node-cb437507-f0f4-43d7-4cc3-5b12d95de79f-3f557072" class="content-block cb-publicaciones cb-logros"> <h5>Immune CODE.</h5> <a href="https://immunerace.adaptivebiotech.com/data/" target="_blank" class="w-inline-block"> <h4 class="title-grey">Our team is collaborating with Adaptive and Microsoft since April 2020 in decoding the adaptive immune response to COVID-19 and providing a detailed, population-level view via an open database, ImmuneCODE.</h4> </a> <a href="https://immunerace.adaptivebiotech.com/data/" target="_blank" class="button-outline bo-small w-button">Access</a> </div> </div> </div> </div> <div id="Team" class="content-section"> <div class="container"> <div class="title-wrap-left"> <h2>Research team.</h2> </div> <div class="w-layout-grid grid"> <div class="scientist-block"> <div class="team-name">Federico Martinón Torres</div> <p class="p4-jobtitle">Principal investigator</p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Antonio Salas Ellacuriaga </strong></div> <p class="p4">Co-Principal Investigator (GENVIP)</p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>José Gómez Rial</strong></div> <p class="p4">Sub-investigator (GENVIP)</p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Irene Rivero Calle </strong></div> <p class="p4">Sub-investigator (GENVIP)</p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Lorenzo Redondo Collazo</strong></div> <p class="p4">Sub-investigator (GENVIP)</p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Ana Isabel Dacosta Urbieta</strong></div> <p class="p4">Sub-investigator (GENVIP)</p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Blanca Díaz Esteban</strong></div> <p class="p4">Sub-investigator (GENVIP)</p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Montserrat López Franco </strong></div> <p class="p4">Sub-investigator (GENVIP)</p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Marta Lendoiro Fuentes</strong></div> <p class="p4">Sub-investigator (GENVIP)</p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Susana Rey García</strong></div> <p class="p4">Sub-investigator (Pediatrics)</p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Luis Valdés Cuadrado</strong></div> <p class="p4">Sub-investigator (Pneumology)</p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Nuria Rodríguez Núñez</strong></div> <p class="p4">Sub-investigator (Pneumology)</p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Vanessa Riveiro Blanco</strong></div> <p class="p4">Sub-investigator (Pneumology)</p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong> Francisco Javier González Barcala </strong></div> <p class="p4">Sub-investigator (Pneumology)</p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Antonio Pose Reino</strong></div> <p class="p4">Sub-investigator (Internal Medicine)</p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Antonio Antela López</strong></div> <p class="p4">Sub-investigator (Internal Medicine)</p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Pablo Varela García</strong></div> <p class="p4">Sub-investigator (Internal Medicine)</p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>María Jesús Domínguez Santalla</strong></div> <p class="p4">Sub-investigator (Internal Medicine)</p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>María Pazo Núñez</strong></div> <p class="p4">Sub-investigator (Internal Medicine)</p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Cristobal Galbán Rodríguez</strong></div> <p class="p4">Sub-investigator (ICU)<br></p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Ana López Lago</strong></div> <p class="p4">Sub-investigator (ICU)<br></p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Elena Giráldez Vázquez</strong></div> <p class="p4">Sub-investigator (ICU)<br></p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Carmen Rivero Velasco</strong></div> <p class="p4">Sub-investigator (ICU)<br></p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Eva Saborido Paz</strong></div> <p class="p4">Sub-investigator (ICU)<br></p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>José Luis García Allut</strong></div> <p class="p4">Sub-investigator (ICU)<br></p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Juan Fernández Villaverde</strong></div> <p class="p4">Sub-investigator (ICU)<br></p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Beatriz Lence Massa</strong></div> <p class="p4">Sub-investigator (ICU)<br></p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Carla Saito Villanueva</strong></div> <p class="p4">Sub-investigator (ICU)<br></p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Manuel Taboada Muñiz</strong></div> <p class="p4">Sub-investigator (Anesthesia and Resuscitation)<br></p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Julian Álvarez Escudero</strong></div> <p class="p4">Sub-investigator (Anesthesia and Resuscitation)<br></p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Gloria Maria Prada Hervella</strong></div> <p class="p4">Sub-investigator (Anesthesia and Resuscitation)<br></p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Mª Luisa Pérez del Molino Bernal</strong></div> <p class="p4">Sub-investigator (Microbiology)</p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Gema Barbeito Castiñeiras</strong></div> <p class="p4">Sub-investigator (Microbiology)</p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Daniel Navarro De la Cruz</strong></div> <p class="p4">Sub-investigator (Microbiology)</p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>José Javier Costa Alcalde</strong></div> <p class="p4">Sub-investigator (Microbiology)</p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Antonio Aguilera Guirao</strong></div> <p class="p4">Sub-investigator (Microbiology)</p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Amparo Coira Nieto</strong></div> <p class="p4">Sub-investigator (Microbiology)</p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Juan Bautista Ortolá Devesa</strong></div> <p class="p4">Sub-investigator (Central Lab)</p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Teresa QueiroVerdes</strong></div> <p class="p4">Sub-investigator (Preventive medicine)<br></p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Hugo Pérez Freixo</strong></div> <p class="p4">Sub-investigator (Preventive medicine)<br></p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Pablo Souto Sanmartín</strong></div> <p class="p4">Sub-investigator (Preventive medicine)<br></p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Mónica Conde Pájaro</strong></div> <p class="p4">Nursing supervisor (Preventive medicine)<br></p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Beatriz Guerra Liñares</strong></div> <p class="p4">Nurse (Preventive medicine)<br></p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Pilar Leborans Iglesias</strong></div> <p class="p4">Nursing supervisor (Pediatrics)<br></p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Eloína Núñez Masid</strong></div> <p class="p4">Manager of the Sanitary Area of Santiago de Compostela e Barbanza<br></p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Manuel Portela Romero</strong></div> <p class="p4">Deputy Director of Pharmaceutical Delivery, Training, Teaching, Research and Innovation<br></p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>María Victoria Carral García</strong></div> <p class="p4">Director of Nursing Processes</p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Lidia Piñeiro Rodríguez</strong></div> <p class="p4">Nurse (GENVIP)</p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Sara Rey Vázquez</strong></div> <p class="p4">Nurse (GENVIP)</p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>José Miguel Sadiki Orayyou</strong></div> <p class="p4">Nurse (GENVIP)</p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>María Soledad Vilas Iglesias</strong></div> <p class="p4">Nurse (GENVIP)</p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Sonia Serén Fernández</strong></div> <p class="p4">Nurse (GENVIP)</p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Luisa García Vicente</strong></div> <p class="p4">Nurse (GENVIP)</p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Alberto Gómez Carballa</strong></div> <p class="p4">Laboratory staff (GENVIP)<br></p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Jacobo Pardo Seco</strong></div> <p class="p4">Laboratory staff (GENVIP)<br></p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Xabier Bello Paderne</strong></div> <p class="p4">Laboratory staff (GENVIP)<br></p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>María José Currás Tuala</strong></div> <p class="p4">Laboratory staff (GENVIP)<br></p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Sara Pischedda</strong></div> <p class="p4">Laboratory staff (GENVIP)<br></p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Sandra Viz Lasheras</strong></div> <p class="p4">Laboratory staff (GENVIP)</p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Miriam Ben García</strong></div> <p class="p4">Laboratory staff (GENVIP)<br></p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Patricia Regueiro Casuso</strong></div> <p class="p4">Laboratory staff (GENVIP)<br></p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Miriam Cebey López</strong></div> <p class="p4">Laboratory staff (GENVIP)</p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Carmen Rodríguez-Tenreiro Sánchez</strong></div> <p class="p4">Research coordinator (GENVIP)<br></p> <p class="p4-workcenter">Complejo Hospitalario Universitario de Santiago de Compostela</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Laura Moreno</strong></div> <p class="p4">Sub Investigador (GENDRES)<br></p> <p class="p4-workcenter">H.Materno Infantil / Hospital Virgen del Camino</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Susana Beatriz Reyes</strong></div> <p class="p4">Sub Investigador (GENDRES)<br></p> <p class="p4-workcenter">Hospital Virgen de la Arrixaca de Murcia</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Sonia Sanchiz</strong></div> <p class="p4">Sub Investigador (GENDRES)<br></p> <p class="p4-workcenter">Hospital Virgen de la Arrixaca de Murcia</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Mari Cruz León</strong></div> <p class="p4">Sub Investigador (GENDRES)<br></p> <p class="p4-workcenter">Hospital Virgen de la Arrixaca de Murcia</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Cristina Calvo</strong></div> <p class="p4">Sub Investigador (GENDRES)<br></p> <p class="p4-workcenter">Hospital La Paz</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Carlos Grasa</strong></div> <p class="p4">Sub Investigador (GENDRES)<br></p> <p class="p4-workcenter">Hospital La Paz</p> </div> <div class="scientist-block"> <div class="team-name"><strong>María Jesús Cabero</strong></div> <p class="p4">Sub Investigador (GENDRES)<br></p> <p class="p4-workcenter">Hospital Valdecilla</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Marta Pareja</strong></div> <p class="p4">Sub Investigador (GENDRES)<br></p> <p class="p4-workcenter">Hospital General de Albacete</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Pablo Rojo</strong></div> <p class="p4">Sub Investigador (GENDRES)<br></p> <p class="p4-workcenter">Hospital 12 Octubre</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Cristina Epalza</strong></div> <p class="p4">Sub Investigador (GENDRES)<br></p> <p class="p4-workcenter">Hospital 12 Octubre</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Patricia Flores Pérez</strong></div> <p class="p4">Sub Investigador (GENDRES)<br></p> <p class="p4-workcenter">Hospital Niño Jesús</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Raquel Jiménez</strong></div> <p class="p4">Sub Investigador (GENDRES)<br></p> <p class="p4-workcenter">Hospital Niño Jesús</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Mª Yolanda Ruíz del Prado</strong></div> <p class="p4">Sub Investigador (GENDRES)<br></p> <p class="p4-workcenter">Hospital San Pedro de La Rioja</p> </div> <div class="scientist-block"> <div class="team-name"><strong>David Moreno</strong></div> <p class="p4">Sub Investigador (GENDRES)<br></p> <p class="p4-workcenter">Hospital Carlos Haya</p> </div> <div class="scientist-block"> <div class="team-name"><strong>Beatríz Carazo</strong></div> <p class="p4">Sub Investigador (GENDRES)<br></p> <p class="p4-workcenter">Hospital Carlos Haya</p> </div> </div> </div> </div> <div class="footer"> <div class="container"> <div class="w-layout-grid footer-grid"> <div id="w-node-_3914c1a4-ee78-df20-64ad-f1b69d859bf3-3f557072" class="footer-column"><img src="images/Logo_Gen-covid.svg" width="140" alt="" class="footer-logo"> <h4>GEN-COVID19 Project</h4> <p class="p4"><strong>Evaluation of the influence of genetic factors on SARS-CoV-2 infection<br>Código de protocolo: </strong>GEN-COVID19<br>Aprobación por el CEIC de Galiciavía fast-track el 18 de marzo de 2020<br><br>Developed from the Clinical, Infectious and Translational Pediatrics of the Hospital Clínico Universitario of Santiago de Compostela, chosen as the best infectious service in Spain (“Best in Class” prize 2018, 2019 and 2020) and from the Genetics, Vaccines, Infections and Pediatrics group (GENVIP), the research international “Zendal” prize 2019 of the Institute of Healthcare Research from Santiago de Compostela.<br></p> <p class="key-words">COVID-19; parallel sequencing; NGS; exomes; whole-genome sequencing; gene expression; RNAseq; nanostring; proteomics.</p> </div> <div id="w-node-_3914c1a4-ee78-df20-64ad-f1b69d859c05-3f557072" class="footer-column"> <div class="title">GENVIP • COVID</div> <a href="index.html" class="footer-link">Abstract</a> <a href="#Targets" class="footer-link">Objetives</a> <a href="#" class="footer-link">Integration</a> <a href="#" class="footer-link">Publications & Achievements</a> <a href="#" class="footer-link">Research team</a> </div> <div id="w-node-_3914c1a4-ee78-df20-64ad-f1b69d859c10-3f557072" class="footer-column"> <div class="title">ENTITIES</div> <a href="http://www.genvip.eu/presentacion.html" target="_blank" class="footer-link">Genvip</a> <a href="http://www.idisantiago.es/" target="_blank" class="footer-link">Idis</a> <a href="https://www.sergas.es/" target="_blank" class="footer-link">Sergas</a> </div> <div id="w-node-_3914c1a4-ee78-df20-64ad-f1b69d859c19-3f557072" class="footer-column"> <div class="title">LINKS</div> <a href="http://www.serviciodepediatriasantiago.es" target="_blank" class="footer-link">Paedriatics service</a> <a href="http://www.genvip.eu/presentacion.html" target="_blank" class="footer-link">Genvip</a> <a href="https://nanostringenvip.com/" target="_blank" class="footer-link">Nanostring</a> </div> </div> <div class="footer-legal-dark"> <div class="legal">Powered by <a href="mailto:info@sisuco.com?subject=%C2%A1Hola!%20-%20Hello!" class="webflow-link">Sisuco – Functional Design Since 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Gen-Covid • Evaluation of the influence of genetic factors on SARS-CoV-2 infection