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href="/degree-charts/engineering-civil-environmental-engineering-course-1-eng/">Engineering (Course 1-ENG)</a></li> <li><a href="/degree-charts/mechanical-engineering-course-2-a/">Engineering (Course 2-A)</a></li> <li><a href="/degree-charts/engineering-chemical-engineering-course-10-eng/">Engineering (Course 10-ENG)</a></li> <li><a href="/degree-charts/engineering-aeronautics-astronautics-course-16-eng/">Engineering (SB, Course 16-ENG)</a></li> <li><a href="/degree-charts/engineering-nuclear-science-engineering-course-22-eng/">Engineering (Course 22-ENG)</a></li> <li><a href="/degree-charts/materials-science-engineering-course-3/">Materials Science and Engineering (Course 3)</a></li> <li><a href="/degree-charts/materials-science-engineering-course-3-a/">Materials Science and Engineering (Course 3-A)</a></li> <li><a href="/degree-charts/phd-materials-science-engineering/">Materials Science and Engineering (PhD)</a></li> <li><a href="/degree-charts/mechanical-ocean-engineering-course-2-oe/">Mechanical and Ocean Engineering (Course 2-OE)</a></li> <li><a href="/degree-charts/mechanical-engineering-course-2/">Mechanical Engineering (Course 2)</a></li> <li><a href="/degree-charts/nuclear-science-engineering-course-22/">Nuclear Science and Engineering (Course 22)</a></li> <li><a href="/degree-charts/phd-nuclear-science-engineering/">Nuclear Science and Engineering (PhD)</a></li> <li class="navheader navheader">School of Humanities, Arts, and Social Sciences</li> <li><a href="/degree-charts/anthropology-course-21a/">Anthropology (Course 21A)</a></li> <li><a href="/degree-charts/comparative-media-studies-cms/">Comparative Media Studies (CMS)</a></li> <li><a href="/degree-charts/master-applied-science-data-economics-development-policy/">Data, Economics, and Design of Policy (MASc)</a></li> <li><a href="/degree-charts/economics-course-14/">Economics (Course 14-1)</a></li> <li><a href="/degree-charts/phd-economics/">Economics (PhD)</a></li> <li><a href="/degree-charts/global-studies-languages-course-21g/">Global Studies and Languages (Course 21G)</a></li> <li><a href="/degree-charts/history-course-21h/">History (Course 21H)</a></li> <li><a href="/degree-charts/humanities-course-21/">Humanities (Course 21)</a></li> <li><a href="/degree-charts/humanities-engineering-course-21e/">Humanities and Engineering (Course 21E)</a></li> <li><a href="/degree-charts/humanities-science-course-21s/">Humanities and Science (Course 21S)</a></li> <li><a href="/degree-charts/sm-linguistics/">Linguistics (SM)</a></li> <li><a href="/degree-charts/linguistics-philosophy-course-24-2/">Linguistics and Philosophy (Course 24-2)</a></li> <li><a href="/degree-charts/literature-course-21l/">Literature (Course 21L)</a></li> <li><a href="/degree-charts/mathematical-economics-course-14-2/">Mathematical Economics (Course 14-2)</a></li> <li><a href="/degree-charts/music-course-21m/">Music (Course 21M-1)</a></li> <li><a href="/degree-charts/philosophy-course-24-1/">Philosophy (Course 24-1)</a></li> <li><a href="/degree-charts/political-science-course-17/">Political Science (Course 17)</a></li> <li><a href="/degree-charts/science-technology-society-sts/">Science, Technology, and Society/Second Major (STS)</a></li> <li><a href="/degree-charts/theater-arts-course-21m-2/">Theater Arts (Course 21M-2)</a></li> <li><a href="/degree-charts/writing-course-21w/">Writing (Course 21W)</a></li> <li class="navheader navheader">Sloan School of Management</li> <li><a href="/degree-charts/business-analytics-course-15-2/">Business Analytics (Course 15-2)</a></li> <li><a href="/degree-charts/finance-course-15-3/">Finance (Course 15-3)</a></li> <li><a href="/degree-charts/management-course-15-1/">Management (Course 15-1)</a></li> <li class="navheader navheader">School of Science</li> <li><a href="/degree-charts/biology-course-7/">Biology (Course 7)</a></li> <li><a href="/degree-charts/brain-cognitive-sciences-course-9/">Brain and Cognitive Sciences (Course 9)</a></li> <li><a href="/degree-charts/phd-brain-cognitive-sciences/">Brain and Cognitive Sciences (PhD)</a></li> <li><a href="/degree-charts/chemistry-course-5/">Chemistry (Course 5)</a></li> <li><a href="/degree-charts/earth-atmospheric-planetary-sciences-course-12/">Earth, Atmospheric and Planetary Sciences (Course 12)</a></li> <li><a href="/degree-charts/phd-earth-atmospheric-planetary-sciences/">Earth, Atmospheric and Planetary Sciences Fields (PhD)</a></li> <li><a href="/degree-charts/mathematics-course-18/">Mathematics (Course 18)</a></li> <li><a href="/degree-charts/phd-mathematics/">Mathematics (PhD)</a></li> <li><a href="/degree-charts/mathematics-computer-science-course-18-c/">Mathematics with Computer Science (Course 18-C)</a></li> <li><a href="/degree-charts/physics-course-8/">Physics (Course 8)</a></li> <li class="navheader navheader">Interdisciplinary Programs (SB)</li> <li><a href="/degree-charts/chemistry-biology-course-5-7/">Chemistry and Biology (Course 5-7)</a></li> <li><a href="/degree-charts/climate-system-science-engineering-course-1-12/">Climate System Science and Engineering (Course 1-12)</a></li> <li><a href="/degree-charts/computation-cognition-6-9/">Computation and Cognition (Course 6-9)</a></li> <li><a href="/degree-charts/computer-science-molecular-biology-course-6-7/">Computer Science and Molecular Biology (Course 6-7)</a></li> <li><a href="/degree-charts/computer-science-economics-data-science-course-6-14/">Computer Science, Economics, and Data Science (Course 6-14)</a></li> <li><a href="/degree-charts/urban-science-planning-computer-science-11-6/">Urban Science and Planning with Computer Science (SB, Course 11-6)</a></li> <li class="navheader navheader">Interdisciplinary Programs (Graduate)</li> <li><a href="/degree-charts/phd-biological-oceanography/">Biological Oceanography (PhD)</a></li> <li><a href="/degree-charts/master-computation-cognition-course-6-9p/">Computation and Cognition (MEng)</a></li> <li><a href="/degree-charts/master-computational-science-engineering/">Computational Science and Engineering (SM)</a></li> <li><a href="/degree-charts/phd-computational-science-engineering/">Computational Science and Engineering (PhD)</a></li> <li><a href="/degree-charts/master-computer-science-molecular-biology-course-6-7p/">Computer Science and Molecular Biology (MEng)</a></li> <li><a href="/degree-charts/master-computer-science-economics-data-science-course-6-14-p/">Computer Science, Economics, and Data Science (MEng)</a></li> <li><a href="/degree-charts/sm-system-design-management/">Engineering and Management (SM)</a></li> <li><a href="/degree-charts/mba-sm-leaders-global-operations/">Leaders for Global Operations (MBA/SM and SM)</a></li> <li><a href="/degree-charts/master-music-technology-computation/">Music Technology and Computation (SM and MASc)</a></li> <li><a href="/degree-charts/master-real-estate-development/">Real Estate Development (SM)</a></li> <li><a href="/degree-charts/interdisciplinary-doctoral-statistics/">Statistics (PhD)</a></li> <li><a href="/degree-charts/master-supply-chain-management/">Supply Chain Management (MEng and MASc)</a></li> <li><a href="/degree-charts/master-technology-policy/">Technology and Policy (SM)</a></li> <li><a href="/degree-charts/master-transportation/">Transportation (SM)</a></li> </ul> </li> <li class="active isparent"><div class="toggle-wrap clearfix"><a href="/subjects/">Subjects</a><button onclick="toggleNav(this); return false;" class="arrow-wrap open" aria-expanded="true"><span class="arrow open">Toggle Subjects</span></button></div> <ul class="nav levelone" id="/subjects/"> <li><a href="/subjects/16/">Aeronautics and Astronautics (Course 16)</a></li> <li><a href="/subjects/as/">Aerospace Studies (AS)</a></li> <li><a href="/subjects/21a/">Anthropology (Course 21A)</a></li> <li><a href="/subjects/4/">Architecture (Course 4)</a></li> <li><a href="/subjects/20/">Biological Engineering (Course 20)</a></li> <li class="active self"><a href="/subjects/7/">Biology (Course 7)</a></li> <li><a href="/subjects/9/">Brain and Cognitive Sciences (Course 9)</a></li> <li><a href="/subjects/10/">Chemical Engineering (Course 10)</a></li> <li><a href="/subjects/5/">Chemistry (Course 5)</a></li> <li><a href="/subjects/1/">Civil and Environmental Engineering (Course 1)</a></li> <li><a href="/subjects/cms/">Comparative Media Studies / Writing (CMS)</a></li> <li><a href="/subjects/21w/">Comparative Media Studies / Writing (Course 21W)</a></li> <li><a href="/subjects/csb/">Computational and Systems Biology (CSB)</a></li> <li><a href="/subjects/cse/">Computational Science and Engineering (CSE)</a></li> <li><a href="/subjects/cc/">Concourse (CC)</a></li> <li><a href="/subjects/ids/">Data, Systems, and Society (IDS)</a></li> <li><a href="/subjects/12/">Earth, Atmospheric, and Planetary Sciences (Course 12)</a></li> <li><a href="/subjects/14/">Economics (Course 14)</a></li> <li><a href="/subjects/ec/">Edgerton Center (EC)</a></li> <li><a href="/subjects/6/">Electrical Engineering and Computer Science (Course 6)</a></li> <li><a href="/subjects/em/">Engineering Management (EM)</a></li> <li><a href="/subjects/es/">Experimental Study Group (ES)</a></li> <li><a href="/subjects/21g/">Global Languages (Course 21G)</a></li> <li><a href="/subjects/hst/">Health Sciences and Technology (HST)</a></li> <li><a href="/subjects/21h/">History (Course 21H)</a></li> <li><a href="/subjects/21/">Humanities (Course 21)</a></li> <li><a href="/subjects/24/">Linguistics and Philosophy (Course 24)</a></li> <li><a href="/subjects/21l/">Literature (Course 21L)</a></li> <li><a href="/subjects/15/">Management (Course 15)</a></li> <li><a href="/subjects/3/">Materials Science and Engineering (Course 3)</a></li> <li><a href="/subjects/18/">Mathematics (Course 18)</a></li> <li><a href="/subjects/2/">Mechanical Engineering (Course 2)</a></li> <li><a href="/subjects/mas/">Media Arts and Sciences (MAS)</a></li> <li><a href="/subjects/ms/">Military Science (MS)</a></li> <li><a href="/subjects/21m/">Music (Course 21M)</a></li> <li><a href="/subjects/ns/">Naval Science (NS)</a></li> <li><a href="/subjects/22/">Nuclear Science and Engineering (Course 22)</a></li> <li><a href="/subjects/8/">Physics (Course 8)</a></li> <li><a href="/subjects/17/">Political Science (Course 17)</a></li> <li><a href="/subjects/sts/">Science, Technology, and Society (STS)</a></li> <li><a href="/subjects/sp/">Special Programs</a></li> <li><a href="/subjects/scm/">Supply Chain Management (SCM)</a></li> <li><a href="/subjects/21t/">Theater Arts (21T)</a></li> <li><a href="/subjects/11/">Urban Studies and Planning (Course 11)</a></li> <li><a href="/subjects/wgs/">Women's and Gender Studies (WGS)</a></li> </ul> </li> </ul>  </div>  </div>  </div>  <div id="right-col"> <div id="content" role="main" class="widthfix"> <h1 class="page-title">Biology (Course 7)</h1> <div id="textcontainer" class="page_content"> </div> <div id="coursestextcontainer" class="page_content"> <a name="coursestext"></a><div id="sc_sccoursedescs"> <h2 class="sectionhead">Undergraduate Subjects</h2><h3 class="subsection"><br/> Introductory Biology</h3><p class="subsectionnote"><em>All five subjects cover the same core material, comprising about 50% of the course, while the remaining material is specialized for each version as described below. Core material includes fundamental principles of biochemistry, genetics, molecular biology, and cell biology. These topics address structure and regulation of genes, structure and synthesis of proteins, how these molecules are integrated into cells and how cells communicate with one another.</em></p><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.012 Introductory Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">U (Fall)</span><br/><span class="courseblockhours">5-0-7 units. BIOLOGY</span><br/><span class="courseblockoptional">Credit cannot also be received for <a href="/search/?P=7.013" title="7.013" class="bubblelink code" onclick="return showCourse(this, '7.013');">7.013</a>, <a href="/search/?P=7.014" title="7.014" class="bubblelink code" onclick="return showCourse(this, '7.014');">7.014</a>, <a href="/search/?P=7.015" title="7.015" class="bubblelink code" onclick="return showCourse(this, '7.015');">7.015</a>, <a href="/search/?P=7.016" title="7.016" class="bubblelink code" onclick="return showCourse(this, '7.016');">7.016</a>, <a href="/search/?P=ES.7012" title="ES.7012" class="bubblelink code" onclick="return showCourse(this, 'ES.7012');">ES.7012</a>, <a href="/search/?P=ES.7013" title="ES.7013" class="bubblelink code" onclick="return showCourse(this, 'ES.7013');">ES.7013</a></span> </p> <p class="courseblockdesc">Exploration into biochemistry and structural biology, molecular and cell biology, genetics and immunology, and viruses and bacteria. Special topics can include cancer biology, aging, and the human microbiome project. Enrollment limited to seating capacity of classroom. Admittance may be controlled by lottery.</p> <p class="courseblockinstructors seemore"><span><i>O. Corradin, E. Lander</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.013 Introductory Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">Acad Year 2024-2025: Not offered<br/> Acad Year 2025-2026: U (Spring)</span><br/><span class="courseblockhours">5-0-7 units. BIOLOGY</span><br/><span class="courseblockoptional">Credit cannot also be received for <a href="/search/?P=7.012" title="7.012" class="bubblelink code" onclick="return showCourse(this, '7.012');">7.012</a>, <a href="/search/?P=7.014" title="7.014" class="bubblelink code" onclick="return showCourse(this, '7.014');">7.014</a>, <a href="/search/?P=7.015" title="7.015" class="bubblelink code" onclick="return showCourse(this, '7.015');">7.015</a>, <a href="/search/?P=7.016" title="7.016" class="bubblelink code" onclick="return showCourse(this, '7.016');">7.016</a>, <a href="/search/?P=ES.7012" title="ES.7012" class="bubblelink code" onclick="return showCourse(this, 'ES.7012');">ES.7012</a>, <a href="/search/?P=ES.7013" title="ES.7013" class="bubblelink code" onclick="return showCourse(this, 'ES.7013');">ES.7013</a></span> </p> <p class="courseblockdesc">Genomic approaches to human biology, including neuroscience, development, immunology, tissue repair and stem cells, tissue engineering, and infectious and inherited diseases, including cancer. Enrollment limited to seating capacity of classroom. Admittance may be controlled by lottery.</p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.014 Introductory Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockterms">U (Spring)</span><br/><span class="courseblockhours">5-0-7 units. BIOLOGY</span><br/><span class="courseblockoptional">Credit cannot also be received for <a href="/search/?P=7.012" title="7.012" class="bubblelink code" onclick="return showCourse(this, '7.012');">7.012</a>, <a href="/search/?P=7.013" title="7.013" class="bubblelink code" onclick="return showCourse(this, '7.013');">7.013</a>, <a href="/search/?P=7.015" title="7.015" class="bubblelink code" onclick="return showCourse(this, '7.015');">7.015</a>, <a href="/search/?P=7.016" title="7.016" class="bubblelink code" onclick="return showCourse(this, '7.016');">7.016</a>, <a href="/search/?P=ES.7012" title="ES.7012" class="bubblelink code" onclick="return showCourse(this, 'ES.7012');">ES.7012</a>, <a href="/search/?P=ES.7013" title="ES.7013" class="bubblelink code" onclick="return showCourse(this, 'ES.7013');">ES.7013</a></span> </p> <p class="courseblockdesc">Studies the fundamental principles of biology and their application towards understanding the Earth as a dynamic system shaped by life. Focuses on environmental life science with an emphasis on biogeochemistry, population genetics, population and community ecology, evolution, and the impact of climate change. Enrollment limited to seating capacity of classroom. Admittance may be controlled by lottery.</p> <p class="courseblockinstructors seemore"><span><i>G. C. Walker, D. Des Marais</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.015 Introductory Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">U (Fall)</span><br/><span class="courseblockhours">5-0-7 units. BIOLOGY</span><br/><span class="courseblockoptional">Credit cannot also be received for <a href="/search/?P=7.012" title="7.012" class="bubblelink code" onclick="return showCourse(this, '7.012');">7.012</a>, <a href="/search/?P=7.013" title="7.013" class="bubblelink code" onclick="return showCourse(this, '7.013');">7.013</a>, <a href="/search/?P=7.014" title="7.014" class="bubblelink code" onclick="return showCourse(this, '7.014');">7.014</a>, <a href="/search/?P=7.016" title="7.016" class="bubblelink code" onclick="return showCourse(this, '7.016');">7.016</a>, <a href="/search/?P=ES.7012" title="ES.7012" class="bubblelink code" onclick="return showCourse(this, 'ES.7012');">ES.7012</a>, <a href="/search/?P=ES.7013" title="ES.7013" class="bubblelink code" onclick="return showCourse(this, 'ES.7013');">ES.7013</a></span> </p> <p class="courseblockdesc">Emphasizes the application of fundamental biological principles to modern, trending topics in biology. Specific modules focus on antibiotic resistance, biotechnology (e.g., genetically-modified organisms and CRISPR-based genome editing), personal genetics and genomics, viruses and vaccines, ancient DNA, and the metabolism of drugs. Includes discussion of the social and ethical issues surrounding modern biology. Limited to 60; admittance may be controlled by lottery.</p> <p class="courseblockinstructors seemore"><span><i>M. Laub, S. Vos</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.016 Introductory Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">U (Spring)</span><br/><span class="courseblockhours">5-0-7 units. BIOLOGY</span><br/><span class="courseblockoptional">Credit cannot also be received for <a href="/search/?P=7.012" title="7.012" class="bubblelink code" onclick="return showCourse(this, '7.012');">7.012</a>, <a href="/search/?P=7.013" title="7.013" class="bubblelink code" onclick="return showCourse(this, '7.013');">7.013</a>, <a href="/search/?P=7.014" title="7.014" class="bubblelink code" onclick="return showCourse(this, '7.014');">7.014</a>, <a href="/search/?P=7.015" title="7.015" class="bubblelink code" onclick="return showCourse(this, '7.015');">7.015</a>, <a href="/search/?P=ES.7012" title="ES.7012" class="bubblelink code" onclick="return showCourse(this, 'ES.7012');">ES.7012</a>, <a href="/search/?P=ES.7013" title="ES.7013" class="bubblelink code" onclick="return showCourse(this, 'ES.7013');">ES.7013</a></span> </p> <p class="courseblockdesc">Introduction to fundamental principles of biochemistry, molecular biology and genetics for understanding the functions of living systems. Covers examples of the use of chemical biology, the use of genetics in biological discovery, principles of cellular organization and communication, immunology, cancer, and engineering biological systems. In addition, includes 21st-century molecular genetics in understanding human health and therapeutic intervention. Enrollment limited to seating capacity of classroom. Admittance may be controlled by lottery.</p> <p class="courseblockinstructors seemore"><span><i>S. Hrvatin, A. Martin</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.00 COVID-19, SARS-CoV-2 and the Pandemic</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">Acad Year 2024-2025: Not offered<br/> Acad Year 2025-2026: U (Fall)</span><br/><span class="courseblockhours">1-0-1 units</span> </p> <p class="courseblockdesc">Lectures by leading experts on the fundamentals of COVID-19 epidemiology, coronavirus and host cell biology, immunity, vaccine development, clinical disease and therapy. Subject can count toward the 6-unit discovery-focused credit limit for first year students. </p> <p class="courseblockinstructors seemore"><span><i>R. Young, F. Batista</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.002 Fundamentals of Experimental Molecular Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">U (Fall, Spring)</span><br/><span class="courseblockhours">1-4-1 units. Partial Lab</span> </p> <p class="courseblockdesc">Introduces the experimental concepts and methods of molecular biology. Covers basic principles of experimental design and data analysis, with an emphasis on the acquisition of practical laboratory experience. Satisfies 6 units of Institute Laboratory credit. Satisfies biology laboratory credit for pre-health professions. Enrollment limited.</p> <p class="courseblockinstructors seemore"><span><i>Fall: T. Baker, T. Schwartz. Spring: T. Schwartz</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.003[J] Applied Molecular Biology Laboratory</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=10.7003J" title="10.7003[J]" class="bubblelink code" onclick="return showCourse(this, '10.7003J');">10.7003[J]</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=7.002" title="7.002" class="bubblelink code" onclick="return showCourse(this, '7.002');">7.002</a> </span><br/><span class="courseblockterms">U (Fall, Spring)</span><br/><span class="courseblockhours">2-7-3 units. Partial Lab</span> </p> <p class="courseblockdesc">Laboratory-based exploration of modern experimental molecular biology. Specific experimental system studied may vary from term to term, depending on instructor. Emphasizes concepts of experimental design, data analysis and communication in biology and how these concepts are applied in the biotechnology industry. Satisfies 6 units of Institute Laboratory credit. Enrollment limited; admittance may be controlled by lottery.</p> <p class="courseblockinstructors seemore"><span><i>Fall: E. Calo, K. Knouse. Spring: L. Case, H. Moura Silva</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.03 Genetics</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: <a href="/search/?P=7.012|7.013|7.014|7.015|7.016" onclick="return showCourse(this, '7.012|7.013|7.014|7.015|7.016');">Biology (GIR)</a> </span><br/><span class="courseblockterms">U (Fall, Spring)</span><br/><span class="courseblockhours">4-0-8 units. REST</span> </p> <p class="courseblockdesc">The principles of genetics with application to the study of biological function at the level of molecules, cells, and multicellular organisms, including humans. Structure and function of genes, chromosomes, and genomes. Biological variation resulting from recombination, mutation, and selection. Population genetics. Use of genetic methods to analyze protein function, gene regulation, and inherited disease. </p> <p class="courseblockinstructors seemore"><span><i>Fall: M. Gehring, P. Reddien. Spring: O. Corradin, F. S谩nchez-Rivera</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.05 General Biochemistry</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: (<a href="/search/?P=7.012|7.013|7.014|7.015|7.016" onclick="return showCourse(this, '7.012|7.013|7.014|7.015|7.016');">Biology (GIR)</a> and <a href="/search/?P=5.12" title="5.12" class="bubblelink code" onclick="return showCourse(this, '5.12');">5.12</a>) or permission of instructor </span><br/><span class="courseblockterms">U (Spring)</span><br/><span class="courseblockhours">5-0-7 units. REST</span><br/><span class="courseblockoptional">Credit cannot also be received for <a href="/search/?P=5.07" title="5.07[J]" class="bubblelink code" onclick="return showCourse(this, '5.07');">5.07[J]</a>, <a href="/search/?P=20.507" title="20.507[J]" class="bubblelink code" onclick="return showCourse(this, '20.507');">20.507[J]</a></span> </p> <p class="courseblockdesc">Contributions of biochemistry toward an understanding of the structure and functioning of organisms, tissues, and cells. Chemistry and functions of constituents of cells and tissues and the chemical and physical-chemical basis for the structures of nucleic acids, proteins, and carbohydrates. Basic enzymology and biochemical reaction mechanisms involved in macromolecular synthesis and degradation, signaling, transport, and movement. General metabolism of carbohydrates, fats, and nitrogen-containing materials such as amino acids, proteins, and related compounds. </p> <p class="courseblockinstructors seemore"><span><i>A. Ringel, M. Vander Heiden, M. Yaffe</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.06 Cell Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: <a href="/search/?P=7.03" title="7.03" class="bubblelink code" onclick="return showCourse(this, '7.03');">7.03</a> and <a href="/search/?P=7.05" title="7.05" class="bubblelink code" onclick="return showCourse(this, '7.05');">7.05</a> </span><br/><span class="courseblockterms">U (Fall, Spring)</span><br/><span class="courseblockhours">4-0-8 units</span> </p> <p class="courseblockdesc">Presents the biology of cells of higher organisms. Studies the structure, function, and biosynthesis of cellular membranes and organelles; cell growth and oncogenic transformation; transport, receptors, and cell signaling; the cytoskeleton, the extracellular matrix, and cell movements; cell division and cell cycle; functions of specialized cell types. Emphasizes the current molecular knowledge of cell biological processes as well as the genetic, biochemical, and other experimental approaches that resulted in these discoveries. </p> <p class="courseblockinstructors seemore"><span><i>Fall:聽 P. Li, S. Lourido. Spring: K. Knouse, R. Lamason</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.08[J] Fundamentals of Chemical Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=5.08J" title="5.08[J]" class="bubblelink code" onclick="return showCourse(this, '5.08J');">5.08[J]</a><br/> Subject meets with <a href="/search/?P=7.80" title="7.80" class="bubblelink code" onclick="return showCourse(this, '7.80');">7.80</a></span><br/><span class="courseblockprereq">Prereq: (<a href="/search/?P=7.012|7.013|7.014|7.015|7.016" onclick="return showCourse(this, '7.012|7.013|7.014|7.015|7.016');">Biology (GIR)</a>, <a href="/search/?P=5.13" title="5.13" class="bubblelink code" onclick="return showCourse(this, '5.13');">5.13</a>, and (<a href="/search/?P=5.07" title="5.07[J]" class="bubblelink code" onclick="return showCourse(this, '5.07');">5.07[J]</a> or <a href="/search/?P=7.05" title="7.05" class="bubblelink code" onclick="return showCourse(this, '7.05');">7.05</a>)) or permission of instructor </span><br/><span class="courseblockterms">U (Spring)</span><br/><span class="courseblockhours">4-0-8 units</span> </p> <p class="courseblockdesc">See description under subject <a href="/search/?P=5.08J" title="5.08[J]" class="bubblelink code" onclick="return showCourse(this, '5.08J');">5.08[J]</a>. </p> <p class="courseblockinstructors seemore"><span><i>B. Imperiali, R. Raines</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.093 Modern Biostatistics</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with <a href="/search/?P=7.573" title="7.573" class="bubblelink code" onclick="return showCourse(this, '7.573');">7.573</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=7.03" title="7.03" class="bubblelink code" onclick="return showCourse(this, '7.03');">7.03</a> and <a href="/search/?P=7.05" title="7.05" class="bubblelink code" onclick="return showCourse(this, '7.05');">7.05</a> </span><br/><span class="courseblockterms">U (Spring; first half of term)</span><br/><span class="courseblockhours">2-0-4 units</span> </p> <p class="courseblockdesc">Provides a practical introduction to probability and statistics used in modern biology. Topics covered include discrete and continuous probability distributions, statistical modeling, hypothesis testing, independence, conditional probability, multiple test corrections, nonparametric methods, clustering, correlation, linear regression, principal components analysis with applications to high-throughput DNA sequencing, and image data analysis. Homework is in the R programming language, but prior programming experience is not required. Students taking the graduate version are expected to explore the subject in greater depth. </p> <p class="courseblockinstructors seemore"><span><i>A. Jain, H. Wong</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.094 Modern Computational Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with <a href="/search/?P=7.574" title="7.574" class="bubblelink code" onclick="return showCourse(this, '7.574');">7.574</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=7.03" title="7.03" class="bubblelink code" onclick="return showCourse(this, '7.03');">7.03</a> and <a href="/search/?P=7.05" title="7.05" class="bubblelink code" onclick="return showCourse(this, '7.05');">7.05</a> </span><br/><span class="courseblockterms">U (Spring; second half of term)</span><br/><span class="courseblockhours">2-0-4 units</span> </p> <p class="courseblockdesc">Introduces modern methods in computational biology, focusing on DNA/RNA/protein analysis. Topics include next-generation DNA sequencing and sequencing data analysis, RNA-seq (bulk and single-cell), and protein dynamics. Students taking the graduate version are expected to explore the subject in greater depth. </p> <p class="courseblockinstructors seemore"><span><i>聽A. Jain, H. Wong</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.102 Introduction to Molecular Biology Techniques</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">U (IAP)</span><br/><span class="courseblockhours">0-5-1 units. Partial Lab</span> </p> <p class="courseblockdesc">Designed primarily for first-year students with little or no lab experience. Introduces basic methods of experimental molecular biology. Specific experiments vary from year-to-year, but will focus on the identification and characterization of bacteria and bacteriophages from the wild using an array of basic methods in molecular biology and microbiology. Biology GIR or Chemistry GIR recommended. Satisfies 6 units of Institute Laboratory credit. Limited to 16; admittance may be controlled by lottery.</p> <p class="courseblockinstructors seemore"><span><i>A. Martin</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.11 Biology Teaching</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">U (Fall, Spring)</span><br/><span class="courseblockhours">Units arranged</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">For qualified undergraduate students interested in gaining some experience in teaching. Laboratory, tutorial, or classroom teaching under the supervision of a faculty member. Students selected by interview. </p> <p class="courseblockinstructors seemore"><span><i>Consult Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.19 Communication in Experimental Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: (<a href="/search/?P=7.06" title="7.06" class="bubblelink code" onclick="return showCourse(this, '7.06');">7.06</a> and (<a href="/search/?P=5.362" title="5.362" class="bubblelink code" onclick="return showCourse(this, '5.362');">5.362</a>, <a href="/search/?P=7.003" title="7.003[J]" class="bubblelink code" onclick="return showCourse(this, '7.003');">7.003[J]</a>, or <a href="/search/?P=20.109" title="20.109" class="bubblelink code" onclick="return showCourse(this, '20.109');">20.109</a>)) or permission of instructor </span><br/><span class="courseblockterms">U (Fall, Spring)</span><br/><span class="courseblockhours">4-4-4 units</span> </p> <p class="courseblockdesc">Students carry out independent literature research. Journal club discussions are used to help students evaluate and write scientific papers. Instruction and practice in written and oral communication is provided.聽 </p> <p class="courseblockinstructors seemore"><span><i>Fall: F. Batista, D. Housman. Spring: C. Kaiser</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.20[J] Human Physiology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=HST.540J" title="HST.540[J]" class="bubblelink code" onclick="return showCourse(this, 'HST.540J');">HST.540[J]</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=7.05" title="7.05" class="bubblelink code" onclick="return showCourse(this, '7.05');">7.05</a> </span><br/><span class="courseblockterms">Acad Year 2024-2025: Not offered<br/> Acad Year 2025-2026: U (Fall)</span><br/><span class="courseblockhours">5-0-7 units</span> </p> <p class="courseblockdesc">Comprehensive exploration of human physiology, emphasizing the molecular basis and applied aspects of organ function and regulation in health and disease. Includes a review of cell structure and function, as well as the mechanisms by which the endocrine and nervous systems integrate cellular metabolism. Special emphasis on examining the cardiovascular, pulmonary, gastrointestinal, and renal systems, as well as liver function, drug metabolism, and pharmacogenetics. </p> <p class="courseblockinstructors seemore"><span><i>M. Krieger, O. Yilmaz</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.21 Microbial Physiology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with <a href="/search/?P=7.62" title="7.62" class="bubblelink code" onclick="return showCourse(this, '7.62');">7.62</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=7.03" title="7.03" class="bubblelink code" onclick="return showCourse(this, '7.03');">7.03</a> and <a href="/search/?P=7.05" title="7.05" class="bubblelink code" onclick="return showCourse(this, '7.05');">7.05</a> </span><br/><span class="courseblockterms">U (Fall)</span><br/><span class="courseblockhours">4-0-8 units</span> </p> <p class="courseblockdesc">Biochemical properties of bacteria and other microorganisms that enable them to grow under a variety of conditions. Interaction between bacteria and bacteriophages. Genetic and metabolic regulation of enzyme action and enzyme formation. Structure and function of components of the bacterial cell envelope. Protein secretion with a special emphasis on its various roles in pathogenesis. Additional topics include bioenergetics, symbiosis, quorum sensing, global responses to DNA damage, and biofilms. Students taking the graduate version are expected to explore the subject in greater depth. </p> <p class="courseblockinstructors seemore"><span><i>G. C. Walker, A. J. Sinskey</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.23[J] Immunology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=20.230J" title="20.230[J]" class="bubblelink code" onclick="return showCourse(this, '20.230J');">20.230[J]</a><br/> Subject meets with <a href="/search/?P=7.63J" title="7.63[J]" class="bubblelink code" onclick="return showCourse(this, '7.63J');">7.63[J]</a>, <a href="/search/?P=20.630J" title="20.630[J]" class="bubblelink code" onclick="return showCourse(this, '20.630J');">20.630[J]</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=7.06" title="7.06" class="bubblelink code" onclick="return showCourse(this, '7.06');">7.06</a> </span><br/><span class="courseblockterms">U (Spring)</span><br/><span class="courseblockhours">5-0-7 units</span> </p> <p class="courseblockdesc">Comprehensive survey of molecular, genetic, and cellular aspects of the immune system. Topics include innate and adaptive immunity; cells and organs of the immune system; hematopoiesis; immunoglobulin, T cell receptor, and major histocompatibility complex (MHC) proteins and genes; development and functions of B and T lymphocytes; immune responses to infections and tumors; hypersensitivity, autoimmunity, and immunodeficiencies. Particular attention to the development and function of the immune system as a whole, as studied by modern methods and techniques. Students taking graduate version explore the subject in greater depth, including study of recent primary literature. </p> <p class="courseblockinstructors seemore"><span><i>S. Spranger, M. Birnbaum</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.24 Advanced Concepts in Immunology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with <a href="/search/?P=7.84" title="7.84" class="bubblelink code" onclick="return showCourse(this, '7.84');">7.84</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=7.23" title="7.23[J]" class="bubblelink code" onclick="return showCourse(this, '7.23');">7.23[J]</a> </span><br/><span class="courseblockterms">U (Spring)</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">Provides a comprehensive and intensified understanding of the relevance of the immune system beyond immunity. Focuses on how the immune system intersects with all aspects of body homeostasis/physiology or disease and how the immune system can be manipulated therapeutically. New advances in the intersection of immunology with cancer biology, neurosciences, metabolism, aging, and maternal-fetal immunology or similar explored. Presents new modern methods and techniques applicable beyond immunology. Includes critical analysis and discussion of assigned readings. Students apply principles learned in class to generate a potential research project, presented in a written form. Students taking graduate version complete additional assignments. </p> <p class="courseblockinstructors seemore"><span><i>H. Moura Silva, S. Spranger</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.26 Molecular Basis of Infectious Disease</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with <a href="/search/?P=7.66" title="7.66" class="bubblelink code" onclick="return showCourse(this, '7.66');">7.66</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=7.06" title="7.06" class="bubblelink code" onclick="return showCourse(this, '7.06');">7.06</a> </span><br/><span class="courseblockterms">U (Spring)</span><br/><span class="courseblockhours">4-0-8 units</span> </p> <p class="courseblockdesc">Focuses on the principles of host-pathogen interactions with an emphasis on infectious diseases of humans. Presents key concepts of pathogenesis through the study of various human pathogens. Includes critical analysis and discussion of assigned readings. Students taking the graduate version are expected to explore the subject in greater depth. </p> <p class="courseblockinstructors seemore"><span><i>E. Chen, R. Lamason</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.27 Principles of Human Disease and Aging</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: <a href="/search/?P=7.06" title="7.06" class="bubblelink code" onclick="return showCourse(this, '7.06');">7.06</a> </span><br/><span class="courseblockterms">U (Spring)</span><br/><span class="courseblockhours">4-0-8 units</span> </p> <p class="courseblockdesc">Covers modern approaches to human diseases and aging, emphasizing the molecular and cellular basis of genetic diseases, infectious diseases, aging, and cancer. Topics include the genetics of simple and complex traits; karyotypic analysis and positional cloning; genetic diagnosis; evolutionary determination of aging, genetic and molecular aspects of aging, HIV/AIDs and other infectious diseases; the roles of oncogenes and tumor suppressors; the interaction between genetics and environment; animal models of human disease, cancer, and aging; and treatment strategies for diseases and aging. Includes a paper describing novel treatment options for a specific disease chosen by each student. </p> <p class="courseblockinstructors seemore"><span><i>D. Housman, Y. Soto-Feliciano</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.28 Molecular Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with <a href="/search/?P=7.58" title="7.58" class="bubblelink code" onclick="return showCourse(this, '7.58');">7.58</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=7.03" title="7.03" class="bubblelink code" onclick="return showCourse(this, '7.03');">7.03</a>; <i>Coreq: <a href="/search/?P=7.05" title="7.05" class="bubblelink code" onclick="return showCourse(this, '7.05');">7.05</a></i> </span><br/><span class="courseblockterms">U (Spring)</span><br/><span class="courseblockhours">5-0-7 units</span> </p> <p class="courseblockdesc">Detailed analysis of the biochemical mechanisms that control the maintenance, expression, and evolution of prokaryotic and eukaryotic genomes. Topics covered in lecture and readings of relevant literature include: gene regulation, DNA replication, genetic recombination, and mRNA translation. Logic of experimental design and data analysis emphasized. Presentations include both lectures and group discussions of representative papers from the literature. Students taking the graduate version are expected to explore the subject in greater depth. </p> <p class="courseblockinstructors seemore"><span><i>E. Calo, Y. Soto-Feliciano</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.29[J] Cellular and Molecular Neurobiology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=9.09J" title="9.09[J]" class="bubblelink code" onclick="return showCourse(this, '9.09J');">9.09[J]</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=7.05" title="7.05" class="bubblelink code" onclick="return showCourse(this, '7.05');">7.05</a> or <a href="/search/?P=9.01" title="9.01" class="bubblelink code" onclick="return showCourse(this, '9.01');">9.01</a> </span><br/><span class="courseblockterms">U (Spring)</span><br/><span class="courseblockhours">4-0-8 units</span> </p> <p class="courseblockdesc">Introduction to the structure and function of the nervous system. Emphasizes the cellular properties of neurons and other excitable cells. Includes the structure and biophysical properties of excitable cells, synaptic transmission, neurochemistry, neurodevelopment, integration of information in simple systems, and detection and information coding during sensory transduction. </p> <p class="courseblockinstructors seemore"><span><i>T. Littleton, S. Prescott</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.30[J] Fundamentals of Ecology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=1.018J" title="1.018[J]" class="bubblelink code" onclick="return showCourse(this, '1.018J');">1.018[J]</a>, <a href="/search/?P=12.031J" title="12.031[J]" class="bubblelink code" onclick="return showCourse(this, '12.031J');">12.031[J]</a></span><br/><span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">U (Fall)</span><br/><span class="courseblockhours">4-0-8 units. REST</span> </p> <p class="courseblockdesc">See description under subject <a href="/search/?P=1.018J" title="1.018[J]" class="bubblelink code" onclick="return showCourse(this, '1.018J');">1.018[J]</a>. </p> <p class="courseblockinstructors seemore"><span><i>M. Follows, D. Des Marais</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.31 Current Topics in Mammalian Biology: Medical Implications</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: <a href="/search/?P=7.06" title="7.06" class="bubblelink code" onclick="return showCourse(this, '7.06');">7.06</a> or permission of instructor </span><br/><span class="courseblockterms">Acad Year 2024-2025: Not offered<br/> Acad Year 2025-2026: U (Fall)</span><br/><span class="courseblockhours">4-0-8 units</span> </p> <p class="courseblockdesc">Covers recent advances in mammalian cell and developmental biology with particular emphasis on approaches that utilize mouse genetics. Combines formal lectures on selected topics with readings of original papers which are discussed in class. Major emphasis on the implications of mechanisms of human genetic diseases. Topics include early mammalian development; genomic imprinting; X inactivation; embryonic stem cells; nuclear reprogramming of somatic cells; cell migration; nervous system development; and central nervous system degenerative diseases such as Alzheimer's and Huntington's disease. Limited to 20.</p> <p class="courseblockinstructors seemore"><span><i>F. Gertler, R. Jaenisch</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.32 Systems Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with <a href="/search/?P=7.81J" title="7.81[J]" class="bubblelink code" onclick="return showCourse(this, '7.81J');">7.81[J]</a>, <a href="/search/?P=8.591J" title="8.591[J]" class="bubblelink code" onclick="return showCourse(this, '8.591J');">8.591[J]</a></span><br/><span class="courseblockprereq">Prereq: (<a href="/search/?P=18.03" title="18.03" class="bubblelink code" onclick="return showCourse(this, '18.03');">18.03</a> and <a href="/search/?P=18.05" title="18.05" class="bubblelink code" onclick="return showCourse(this, '18.05');">18.05</a>) or permission of instructor </span><br/><span class="courseblockterms">U (Fall)</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">Introduction to cellular and population-level systems biology with an emphasis on synthetic biology, modeling of genetic networks, cell-cell interactions, and evolutionary dynamics. Cellular systems include genetic switches and oscillators, network motifs, genetic network evolution, and cellular decision-making. Population-level systems include models of pattern formation, cell-cell communications, and evolutionary systems biology. Students taking graduate version explore the subject in more depth. </p> <p class="courseblockinstructors seemore"><span><i>J. Gore</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.33[J] Evolutionary Biology: Concepts, Models and Computation</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=6.4710J" title="6.4710[J]" class="bubblelink code" onclick="return showCourse(this, '6.4710J');">6.4710[J]</a></span><br/><span class="courseblockprereq">Prereq: (<a href="/search/?P=6.100A" title="6.100A" class="bubblelink code" onclick="return showCourse(this, '6.100A');">6.100A</a> and <a href="/search/?P=7.03" title="7.03" class="bubblelink code" onclick="return showCourse(this, '7.03');">7.03</a>) or permission of instructor </span><br/><span class="courseblockterms">Acad Year 2024-2025: Not offered<br/> Acad Year 2025-2026: U (Spring)</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">Explores and illustrates how evolution explains biology, with an emphasis on computational model building for analyzing evolutionary data. Covers key concepts of biological evolution, including adaptive evolution, neutral evolution, evolution of sex, genomic conflict, speciation, phylogeny and comparative methods, life's history, coevolution, human evolution, and evolution of disease. </p> <p class="courseblockinstructors seemore"><span><i>R. Berwick, D. Bartel</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.340-7.344 Advanced Undergraduate Seminar</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: <a href="/search/?P=7.06" title="7.06" class="bubblelink code" onclick="return showCourse(this, '7.06');">7.06</a> or <a href="/search/?P=7.28" title="7.28" class="bubblelink code" onclick="return showCourse(this, '7.28');">7.28</a> </span><br/><span class="courseblockterms">U (Fall, Spring)</span><br/><span class="courseblockhours">2-0-4 units</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Seminars covering topics of current interest in biology with a focus on how to understand experimental methods and design and how to critically read the primary research literature. Small class size facilitates discussions and interactions with an active research scientist. Students visit research laboratories to see firsthand how biological research is conducted. Contact Biology Education Office for topics. </p> <p class="courseblockinstructors seemore"><span><i>H. R. Horvitz</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.345-7.349 Advanced Undergraduate Seminar</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: <a href="/search/?P=7.06" title="7.06" class="bubblelink code" onclick="return showCourse(this, '7.06');">7.06</a> or <a href="/search/?P=7.28" title="7.28" class="bubblelink code" onclick="return showCourse(this, '7.28');">7.28</a> </span><br/><span class="courseblockterms">U (Fall, Spring)</span><br/><span class="courseblockhours">2-0-4 units</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Seminars covering topics of current interest in biology with a focus on how to understand experimental methods and design and how to critically read the primary research literature. Small class size facilitates discussions and interactions with an active research scientist. Students visit research laboratories to see firsthand how biological research is conducted. Contact Biology Education Office for topics. </p> <p class="courseblockinstructors seemore"><span><i>H. R. Horvitz</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.35 Human Genetics and Genomics</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with <a href="/search/?P=7.75" title="7.75" class="bubblelink code" onclick="return showCourse(this, '7.75');">7.75</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=7.06" title="7.06" class="bubblelink code" onclick="return showCourse(this, '7.06');">7.06</a>, (<a href="/search/?P=7.03" title="7.03" class="bubblelink code" onclick="return showCourse(this, '7.03');">7.03</a> and <a href="/search/?P=7.05" title="7.05" class="bubblelink code" onclick="return showCourse(this, '7.05');">7.05</a>), or permission of instructor </span><br/><span class="courseblockterms">U (Spring)</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">Upper-level seminar offering in-depth analysis and engaged discussion of primary literature on the dimensions and phenotypic consequences of variation in human genes, chromosomes, and genomes. Topics include the human genome project; pedigree analysis; mutation and selection; linkage and association studies; medical genetics and disease; sex chromosomes and sex differences; the biology of the germ line; epigenetics, imprinting, and transgenerational inheritance; human origins; and evolutionary and population genetics. Students taking graduate version complete additional assignments. Limited to 20 total for versions meeting together.</p> <p class="courseblockinstructors seemore"><span><i>D. Page</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.36 The CRISPR Revolution: Engineering the Genome for Basic Science and Clinical Medicine (New)</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with <a href="/search/?P=7.91" title="7.91" class="bubblelink code" onclick="return showCourse(this, '7.91');">7.91</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=7.06" title="7.06" class="bubblelink code" onclick="return showCourse(this, '7.06');">7.06</a> or permission of instructor </span><br/><span class="courseblockterms">U (Fall)</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">Provides a conceptual and technical understanding of genome editing systems and their research and clinical applications. Focuses on fundamental CRISPR biology in bacteria, methodologies for manipulating the genome with CRISPR, and the application of genome engineering in research and medicine. Combines lectures and literature discussions with critical analysis and assigned readings, with the goal of better understanding how key discoveries were made and how these are applied in the real work. Class work includes brief writing assignments as well as a final research proposal and scientific presentation. Students taking the graduate version explore the subject in greater depth, in part through additional assignments. </p> <p class="courseblockinstructors seemore"><span><i>F. S谩nchez-Rivera, J. Weissman</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.37[J] Molecular and Engineering Aspects of Biotechnology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=10.441J" title="10.441[J]" class="bubblelink code" onclick="return showCourse(this, '10.441J');">10.441[J]</a>, <a href="/search/?P=20.361J" title="20.361[J]" class="bubblelink code" onclick="return showCourse(this, '20.361J');">20.361[J]</a></span><br/><span class="courseblockprereq">Prereq: (<a href="/search/?P=7.06" title="7.06" class="bubblelink code" onclick="return showCourse(this, '7.06');">7.06</a> and (<a href="/search/?P=2.005" title="2.005" class="bubblelink code" onclick="return showCourse(this, '2.005');">2.005</a>, 3.012, 5.60, or <a href="/search/?P=20.110" title="20.110[J]" class="bubblelink code" onclick="return showCourse(this, '20.110');">20.110[J]</a>)) or permission of instructor </span><br/><span class="courseblockterms">Acad Year 2024-2025: Not offered<br/> Acad Year 2025-2026: U (Spring)</span><br/><span class="courseblockhours">4-0-8 units</span><br/><span class="courseblockoptional">Credit cannot also be received for <a href="/search/?P=7.371" title="7.371" class="bubblelink code" onclick="return showCourse(this, '7.371');">7.371</a></span> </p> <p class="courseblockdesc">Covers biological and bioengineering principles underlying the development and therapeutic use of recombinant proteins and stem cells; glycoengineering of recombinant proteins; normal and pathological signaling by growth factors and their receptors; receptor trafficking; monoclonal antibodies as therapeutics; protein pharmacology and delivery; stem cell-derived tissues as therapeutics; RNA therapeutics; combinatorial protein engineering; and new antitumor drugs. </p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.371 Biological and Engineering Principles Underlying Novel Biotherapeutics</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: <a href="/search/?P=7.06" title="7.06" class="bubblelink code" onclick="return showCourse(this, '7.06');">7.06</a> </span><br/><span class="courseblockterms">U (Fall)</span><br/><span class="courseblockhours">4-0-8 units</span><br/><span class="courseblockoptional">Credit cannot also be received for <a href="/search/?P=7.37" title="7.37[J]" class="bubblelink code" onclick="return showCourse(this, '7.37');">7.37[J]</a>, <a href="/search/?P=10.441" title="10.441[J]" class="bubblelink code" onclick="return showCourse(this, '10.441');">10.441[J]</a>, <a href="/search/?P=20.361" title="20.361[J]" class="bubblelink code" onclick="return showCourse(this, '20.361');">20.361[J]</a></span> </p> <p class="courseblockdesc">Covers biological and bioengineering principles underlying the development and therapeutic use of recombinant proteins and immune cells. Special attention to monoclonal antibodies and engineered immune system cells as therapeutics; protein- and glyco- engineering to enhance protein function; protein pharmacology and delivery; nucleic acid- based biotherapeutics; generation of functional cells and tissues from embryonic stem cells and iPS cells; and immune cell-cancer cell interactions in cancer immunotherapy. </p> <p class="courseblockinstructors seemore"><span><i>J. Chen, H. Lodish</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.38 Design Principles of Biological Systems</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with <a href="/search/?P=7.83" title="7.83" class="bubblelink code" onclick="return showCourse(this, '7.83');">7.83</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=7.06" title="7.06" class="bubblelink code" onclick="return showCourse(this, '7.06');">7.06</a> or permission of instructor </span><br/><span class="courseblockterms">U (Fall)</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">Introduces students to biological control mechanisms governing decision-making and tools to decipher, model, and perturb these mechanisms. Systems presented include signal transduction, cell cycle control, developmental biology, and the immune system. These systems provide examples of feedback and feedforward control, oscillators, kinetic proofreading, spatial and temporal averaging, and pattern formation. Students taking graduate version complete additional assignments. </p> <p class="courseblockinstructors seemore"><span><i>D. Lew, H. Wong</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.45 The Hallmarks of Cancer</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with <a href="/search/?P=7.85" title="7.85" class="bubblelink code" onclick="return showCourse(this, '7.85');">7.85</a></span><br/><span class="courseblockprereq">Prereq: None. <i>Coreq: <a href="/search/?P=7.06" title="7.06" class="bubblelink code" onclick="return showCourse(this, '7.06');">7.06</a></i> </span><br/><span class="courseblockterms">U (Fall)</span><br/><span class="courseblockhours">4-0-8 units</span> </p> <p class="courseblockdesc">Provides a comprehensive introduction to the fundamentals of cancer biology and cancer treatment. Topics include cancer genetics, genomics, and epigenetics; familial cancer syndromes; signal transduction, cell cycle control, and apoptosis; cancer metabolism; stem cells and cancer; metastasis; cancer immunology and immunotherapy; conventional and molecularly-targeted therapies; and early detection and prevention. Students taking graduate version complete additional assignments. </p> <p class="courseblockinstructors seemore"><span><i>M. Hemann, T. Jacks</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.46 Building with Cells</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with <a href="/search/?P=7.86" title="7.86" class="bubblelink code" onclick="return showCourse(this, '7.86');">7.86</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=7.03" title="7.03" class="bubblelink code" onclick="return showCourse(this, '7.03');">7.03</a> and <a href="/search/?P=7.05" title="7.05" class="bubblelink code" onclick="return showCourse(this, '7.05');">7.05</a> </span><br/><span class="courseblockterms">U (Fall)</span><br/><span class="courseblockhours">4-0-8 units</span> </p> <p class="courseblockdesc">Focuses on fundamental principles of developmental biology by which cells build organs and organisms. Analyzes the pivotal role of stem cells in tissue maintenance or repair, and in treatment of disease. Explores how to integrate this聽knowledge with engineering tools to construct functional tissue structures.聽Students taking graduate version complete additional assignments </p> <p class="courseblockinstructors seemore"><span><i>L. Boyer, P. Li</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.458[J] Advances in Biomanufacturing</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=10.03J" title="10.03[J]" class="bubblelink code" onclick="return showCourse(this, '10.03J');">10.03[J]</a><br/> Subject meets with <a href="/search/?P=7.548J" title="7.548[J]" class="bubblelink code" onclick="return showCourse(this, '7.548J');">7.548[J]</a>, <a href="/search/?P=10.53J" title="10.53[J]" class="bubblelink code" onclick="return showCourse(this, '10.53J');">10.53[J]</a></span><br/><span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">U (Spring; second half of term)</span><br/><span class="courseblockhours">1-0-2 units</span> </p> <p class="courseblockdesc">Seminar examines how biopharmaceuticals, an increasingly important class of pharmaceuticals, are manufactured. Topics range from fundamental bioprocesses to new technologies to the economics of biomanufacturing. Also covers the impact of globalization on regulation and quality approaches as well as supply chain integrity. Students taking graduate version complete additional assignments. </p> <p class="courseblockinstructors seemore"><span><i>J. C. Love, A. Sinskey, S. Springs</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.49[J] Developmental Neurobiology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=9.18J" title="9.18[J]" class="bubblelink code" onclick="return showCourse(this, '9.18J');">9.18[J]</a><br/> Subject meets with <a href="/search/?P=7.69J" title="7.69[J]" class="bubblelink code" onclick="return showCourse(this, '7.69J');">7.69[J]</a>, <a href="/search/?P=9.181J" title="9.181[J]" class="bubblelink code" onclick="return showCourse(this, '9.181J');">9.181[J]</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=7.03" title="7.03" class="bubblelink code" onclick="return showCourse(this, '7.03');">7.03</a>, <a href="/search/?P=7.05" title="7.05" class="bubblelink code" onclick="return showCourse(this, '7.05');">7.05</a>, <a href="/search/?P=9.01" title="9.01" class="bubblelink code" onclick="return showCourse(this, '9.01');">9.01</a>, or permission of instructor </span><br/><span class="courseblockterms">U (Spring)</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">Considers molecular control of neural specification, formation of neuronal connections, construction of neural systems, and the contributions of experience to shaping brain structure and function. Topics include: neural induction and pattern formation, cell lineage and fate determination, neuronal migration, axon guidance, synapse formation and stabilization, activity-dependent development and critical periods, development of behavior. Students taking graduate version complete additional readings that will be addressed in their mid-term and final exams. </p> <p class="courseblockinstructors seemore"><span><i>E. Nedivi</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.390 Practical Internship Experience in Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">U (Fall, IAP, Spring, Summer)</span><br/><span class="courseblockhours">0-1-0 units</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">For Course 7, 5-7, and 6-7 students participating in curriculum-related off-campus internship experiences in biology. Before enrolling, students must consult the Biology Education Office for details on procedures and restrictions, and have approval from their faculty advisor. Subject to department approval.聽 Upon completion, the student must submit a write-up of the experience, approved by their faculty advisor. </p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.391 Independent Study in Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">Acad Year 2024-2025: U (Fall, Spring, Summer)<br/> Acad Year 2025-2026: Not offered</span><br/><span class="courseblockhours">Units arranged [P/D/F]</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Program of study or research to be arranged with a department faculty member. </p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.392 Independent Study in Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">Acad Year 2024-2025: U (Fall, IAP, Spring)<br/> Acad Year 2025-2026: Not offered</span><br/><span class="courseblockhours">Units arranged</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Program of study or research to be arranged with a department faculty member. </p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.393 Independent Study in Genetics</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">Acad Year 2024-2025: U (Fall, Spring)<br/> Acad Year 2025-2026: Not offered</span><br/><span class="courseblockhours">Units arranged</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Program of study or research to be arranged with a department faculty member. </p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.394 Independent Study in Biochemistry</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">Acad Year 2024-2025: U (Fall, Spring)<br/> Acad Year 2025-2026: Not offered</span><br/><span class="courseblockhours">Units arranged</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Program of study or research to be arranged with a department faculty member. </p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.395 Independent Study in Cell and Molecular Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">Acad Year 2024-2025: U (Fall, Spring)<br/> Acad Year 2025-2026: Not offered</span><br/><span class="courseblockhours">Units arranged</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Program of study or research to be arranged with a department faculty member. </p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.396 Independent Study in Experimental Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">Acad Year 2024-2025: U (Fall, IAP, Spring)<br/> Acad Year 2025-2026: Not offered</span><br/><span class="courseblockhours">Units arranged [P/D/F]</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Program of study or research to be arranged with a department faculty member. </p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.C01 Machine Learning in Molecular and Cellular Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with <a href="/search/?P=3.C01J" title="3.C01[J]" class="bubblelink code" onclick="return showCourse(this, '3.C01J');">3.C01[J]</a>, <a href="/search/?P=3.C51J" title="3.C51[J]" class="bubblelink code" onclick="return showCourse(this, '3.C51J');">3.C51[J]</a>, <a href="/search/?P=7.C51" title="7.C51" class="bubblelink code" onclick="return showCourse(this, '7.C51');">7.C51</a>, <a href="/search/?P=10.C01J" title="10.C01[J]" class="bubblelink code" onclick="return showCourse(this, '10.C01J');">10.C01[J]</a>, <a href="/search/?P=10.C51J" title="10.C51[J]" class="bubblelink code" onclick="return showCourse(this, '10.C51J');">10.C51[J]</a>, <a href="/search/?P=20.C01J" title="20.C01[J]" class="bubblelink code" onclick="return showCourse(this, '20.C01J');">20.C01[J]</a>, <a href="/search/?P=20.C51J" title="20.C51[J]" class="bubblelink code" onclick="return showCourse(this, '20.C51J');">20.C51[J]</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=7.012|7.013|7.014|7.015|7.016" onclick="return showCourse(this, '7.012|7.013|7.014|7.015|7.016');">Biology (GIR)</a>, <a href="/search/?P=6.100A" title="6.100A" class="bubblelink code" onclick="return showCourse(this, '6.100A');">6.100A</a>, <a href="/search/?P=6.C01" title="6.C01" class="bubblelink code" onclick="return showCourse(this, '6.C01');">6.C01</a>, and <a href="/search/?P=7.05" title="7.05" class="bubblelink code" onclick="return showCourse(this, '7.05');">7.05</a> </span><br/><span class="courseblockterms">U (Spring)</span><br/><span class="courseblockhours">2-0-4 units</span> </p> <p class="courseblockdesc">Introduces machine learning as a tool to understand natural biological systems, with an evolving emphasis on problems in molecular and cellular biology that are being actively advanced using machine learning. Students design, implement, and interpret machine learning approaches to aid in predicting protein structure, probing protein structure/function relationships, and imaging biological systems at scales ranging from the atomic to cellular. Students taking graduate version complete an additional project-based assignment. Students cannot receive credit without completion of the core subject <a href="/search/?P=6.C01" title="6.C01" class="bubblelink code" onclick="return showCourse(this, '6.C01');">6.C01</a>. </p> <p class="courseblockinstructors seemore"><span><i>J. Davis</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.S391 Special Subject in Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">U (Fall, IAP, Spring, Summer)</span><br/><span class="courseblockhours">Units arranged [P/D/F]</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Covers material in various fields of biology not offered by the regular subjects of instruction. </p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.S392 Special Subject in Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">U (Fall, IAP, Spring)<br/> Not offered regularly; consult department</span><br/><span class="courseblockhours">Units arranged [P/D/F]</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Covers material in various fields of biology not offered by the regular subjects of instruction. </p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.S399 Special Subject in Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">U (Fall, IAP, Spring)<br/> Not offered regularly; consult department</span><br/><span class="courseblockhours">Units arranged</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Covers material in various fields of biology not offered by the regular subjects of instruction. </p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.UR Undergraduate Research</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of department </span><br/><span class="courseblockterms">U (Fall, IAP, Spring, Summer)</span><br/><span class="courseblockhours">Units arranged [P/D/F]</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Undergraduate research opportunities in the Department of Biology. </p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.URG Undergraduate Research</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of department </span><br/><span class="courseblockterms">U (Fall, IAP, Spring)</span><br/><span class="courseblockhours">Units arranged</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Undergraduate research opportunities in the Department of Biology. </p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><h2 class="sectionhead">Graduate Subjects</h2><h3 class="subsection">MIT-WHOI Joint Program in Oceanography</h3><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.410 Applied Statistics</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Spring)</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">Provides an introduction to modern applied statistics. Topics include likelihood-based methods for estimation, confidence intervals, and hypothesis-testing; bootstrapping; time series modeling; linear models; nonparametric regression; and model selection. Organized around examples drawn from the recent literature. </p> <p class="courseblockinstructors seemore"><span><i>WHOI Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.411 Seminars in Biological Oceanography</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Fall, Spring)</span><br/><span class="courseblockhours">Units arranged [P/D/F]</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Selected topics in biological oceanography. </p> <p class="courseblockinstructors seemore"><span><i>WHOI Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.421 Problems in Biological Oceanography</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Fall, Spring)</span><br/><span class="courseblockhours">Units arranged [P/D/F]</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Advanced problems in biological oceanography with assigned reading and consultation. </p> <p class="courseblockinstructors seemore"><span><i>Information: M. Neubert (WHOI)</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.430 Topics in Quantitative Marine Science</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Fall, Spring)</span><br/><span class="courseblockhours">2-0-4 units</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Lectures and discussions on quantitative marine ecology. Topics vary from year to year. </p> <p class="courseblockinstructors seemore"><span><i>WHOI Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.431 Topics in Marine Ecology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Fall, Spring)</span><br/><span class="courseblockhours">2-0-4 units</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Lectures and discussions on ecological principles and processes in marine populations, communities, and ecosystems. Topics vary from year to year. </p> <p class="courseblockinstructors seemore"><span><i>M. Neubert</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.432 Topics in Marine Physiology and Biochemistry</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Spring)</span><br/><span class="courseblockhours">2-0-4 units</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Lectures and discussions on physiological and biochemical processes in marine organisms. Topics vary from year to year. </p> <p class="courseblockinstructors seemore"><span><i>WHOI Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.433 Topics in Biological Oceanography</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Spring)</span><br/><span class="courseblockhours">2-0-4 units</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Lectures and discussions on biological oceanography. Topics vary from year to year. </p> <p class="courseblockinstructors seemore"><span><i>S. Laney, M. Hahn</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.434 Topics in Zooplankton Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">Acad Year 2024-2025: Not offered<br/> Acad Year 2025-2026: G (Fall, Spring)</span><br/><span class="courseblockhours">2-0-4 units</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Lectures and discussions on the biology of marine zooplankton. Topics vary from year to year. </p> <p class="courseblockinstructors seemore"><span><i>WHOI Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.435 Topics in Benthic Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">Acad Year 2024-2025: Not offered<br/> Acad Year 2025-2026: G (Fall, Spring)</span><br/><span class="courseblockhours">2-0-4 units</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Lectures and discussions on the biology of marine benthos. Topics vary from year to year. </p> <p class="courseblockinstructors seemore"><span><i>WHOI Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.436 Topics in Phytoplankton Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">Acad Year 2024-2025: Not offered<br/> Acad Year 2025-2026: G (Fall, Spring)</span><br/><span class="courseblockhours">2-0-4 units</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Lectures and discussion on the biology of marine phytoplankton. Topics vary from year to year. </p> <p class="courseblockinstructors seemore"><span><i>WHOI Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.437 Topics in Molecular Biological Oceanography</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">Acad Year 2024-2025: Not offered<br/> Acad Year 2025-2026: G (Fall, Spring)</span><br/><span class="courseblockhours">2-0-4 units</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Lectures and discussion on molecular biological oceanography. Topics vary from year to year. </p> <p class="courseblockinstructors seemore"><span><i>WHOI Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.438 Topics in the Behavior of Marine Animals</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">Acad Year 2024-2025: Not offered<br/> Acad Year 2025-2026: G (Fall, Spring)</span><br/><span class="courseblockhours">2-0-4 units</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Lectures and discussion on the behavioral biology of marine animals. Topics vary from year to year. </p> <p class="courseblockinstructors seemore"><span><i>WHOI Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.439 Topics in Marine Microbiology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Spring)</span><br/><span class="courseblockhours">2-0-4 units</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Lectures and discussion on the biology of marine prokaryotes. Topics vary from year to year. </p> <p class="courseblockinstructors seemore"><span><i>WHOI Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.440 An Introduction to Mathematical Ecology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: <a href="/search/?P=18.01|18.01A|18.014" onclick="return showCourse(this, '18.01|18.01A|18.014');">Calculus I (GIR)</a>, <a href="/search/?P=1.018" title="1.018[J]" class="bubblelink code" onclick="return showCourse(this, '1.018');">1.018[J]</a>, or permission of instructor </span><br/><span class="courseblockterms">G (Spring)</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">Covers the basic models of population growth, demography, population interaction (competition, predation, mutualism), food webs, harvesting, and infectious disease, and the mathematical tools required for their analysis. Because these tools are also basic to the analysis of models in biochemistry, physiology, and behavior, subject also broadly relevant to students whose interests are not limited to ecological problems. </p> <p class="courseblockinstructors seemore"><span><i>M. Neubert (WHOI)</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.470 Biological Oceanography</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Spring)</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">Intended for students with advanced training in biology. Intensive overview of biological oceanography. Major paradigms discussed, and dependence of biological processes in the ocean on physical and chemical aspects of the environment examined. Surveys the diversity of marine habitats, major groups of taxa inhabiting those habitats, and the general biology of the various taxa: the production and consumption of organic material in the ocean, as well as factors controlling those processes. Species diversity, structure of marine food webs, and the flow of energy within different marine habitats are detailed and contrasted. </p> <p class="courseblockinstructors seemore"><span><i>WHOI Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.491 Research in Biological Oceanography</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Fall, Spring, Summer)</span><br/><span class="courseblockhours">Units arranged [P/D/F]</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Directed research in biological oceanography not leading to graduate thesis and initiated prior to the qualifying exam. </p> <p class="courseblockinstructors seemore"><span><i>WHOI Staff</i></span></p> </div><h3 class="subsection">Microbiology (MICRO)</h3><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.492[J] Methods and Problems in Microbiology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=1.86J" title="1.86[J]" class="bubblelink code" onclick="return showCourse(this, '1.86J');">1.86[J]</a>, <a href="/search/?P=20.445J" title="20.445[J]" class="bubblelink code" onclick="return showCourse(this, '20.445J');">20.445[J]</a></span><br/><span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">G (Fall)</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">Students will read and discuss primary literature covering key areas of microbial research with emphasis on methods and approaches used to understand and manipulate microbes. Preference to first-year Microbiology and Biology students.</p> <p class="courseblockinstructors seemore"><span><i>M. Laub</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.493[J] Microbial Genetics and Evolution</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=1.87J" title="1.87[J]" class="bubblelink code" onclick="return showCourse(this, '1.87J');">1.87[J]</a>, <a href="/search/?P=12.493J" title="12.493[J]" class="bubblelink code" onclick="return showCourse(this, '12.493J');">12.493[J]</a>, <a href="/search/?P=20.446J" title="20.446[J]" class="bubblelink code" onclick="return showCourse(this, '20.446J');">20.446[J]</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=7.03" title="7.03" class="bubblelink code" onclick="return showCourse(this, '7.03');">7.03</a>, <a href="/search/?P=7.05" title="7.05" class="bubblelink code" onclick="return showCourse(this, '7.05');">7.05</a>, or permission of instructor </span><br/><span class="courseblockterms">G (Fall)</span><br/><span class="courseblockhours">4-0-8 units</span> </p> <p class="courseblockdesc">Covers aspects of microbial genetic and genomic analyses, central dogma, horizontal gene transfer, and evolution. </p> <p class="courseblockinstructors seemore"><span><i>A. D. Grossman, O. Cordero</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.494 Research Problems in Microbiology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Fall, Spring, Summer)</span><br/><span class="courseblockhours">Units arranged [P/D/F]</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Directed research in the fields of microbial science and engineering. </p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.498 Teaching Experience in Microbiology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Fall, Spring)</span><br/><span class="courseblockhours">Units arranged [P/D/F]</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">For qualified graduate students in the Microbiology graduate program interested in teaching. Classroom or laboratory teaching under the supervision of a faculty member. </p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.499 Research Rotations in Microbiology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: None. <i>Coreq: <a href="/search/?P=7.492" title="7.492[J]" class="bubblelink code" onclick="return showCourse(this, '7.492');">7.492[J]</a> or <a href="/search/?P=7.493" title="7.493[J]" class="bubblelink code" onclick="return showCourse(this, '7.493');">7.493[J]</a></i>; permission of instructor </span><br/><span class="courseblockterms">G (Fall, Spring)</span><br/><span class="courseblockhours">Units arranged [P/D/F]</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Introduces students to faculty participating in the interdepartmental Microbiology graduate program through a series of three lab rotations, which provide broad exposure to microbiology research at MIT. Students select a lab for thesis research by the end of their first year. Given the interdisciplinary nature of the program and the many research programs available, students may be able to work jointly with more than one research advisor. Limited to students in the Microbiology graduate program.</p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.MTHG Microbiology Graduate Thesis</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Fall, IAP, Spring, Summer)</span><br/><span class="courseblockhours">Units arranged</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Program of research leading to the writing of a PhD thesis. To be arranged by the student and the appropriate MIT faculty member. </p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><h3 class="subsection">Biology</h3><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.50 Method and Logic in Molecular Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: None. <i>Coreq: <a href="/search/?P=7.51" title="7.51" class="bubblelink code" onclick="return showCourse(this, '7.51');">7.51</a> and <a href="/search/?P=7.52" title="7.52" class="bubblelink code" onclick="return showCourse(this, '7.52');">7.52</a></i>; or permission of instructor </span><br/><span class="courseblockterms">G (Fall)</span><br/><span class="courseblockhours">4-0-8 units</span> </p> <p class="courseblockdesc">Logic, experimental design and methods in biology, using discussions of the primary literature to discern the principles of biological investigation in making discoveries and testing hypotheses. In collaboration with faculty, students also apply those principles to generate a potential research project, presented in both written and oral form. Limited to Course 7 graduate students.</p> <p class="courseblockinstructors seemore"><span><i>I. Cheeseman, R. Lehmann, D. Lew, S. Vos, J. Weissman, Y. Yamashita</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.51 Principles of Biochemical Analysis</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Fall)</span><br/><span class="courseblockhours">6-0-6 units</span> </p> <p class="courseblockdesc">Principles of protein biochemistry, emphasizing structure, equilibrium studies, kinetics, and experimental design. Topics include macromolecular binding and specificity, allosteric systems, mechanisms of inhibition, enzyme principles, single-molecule studies, structure-function relationships, molecular evolution, and library methods. Case studies examine mechanisms of transcription factors, kinases, molecular machines, and other proteins. </p> <p class="courseblockinstructors seemore"><span><i>L. Case, A. Keating</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.52 Genetics for Graduate Students</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Fall)</span><br/><span class="courseblockhours">4-0-8 units</span> </p> <p class="courseblockdesc">Principles and approaches of genetic analysis, including Mendelian inheritance and prokaryotic genetics, yeast genetics, developmental genetics, neurogenetics, and human genetics. </p> <p class="courseblockinstructors seemore"><span><i>C. Kaiser</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.540[J] Advances in Chemical Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=5.54J" title="5.54[J]" class="bubblelink code" onclick="return showCourse(this, '5.54J');">5.54[J]</a>, <a href="/search/?P=20.554J" title="20.554[J]" class="bubblelink code" onclick="return showCourse(this, '20.554J');">20.554[J]</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=5.07" title="5.07[J]" class="bubblelink code" onclick="return showCourse(this, '5.07');">5.07[J]</a>, <a href="/search/?P=5.13" title="5.13" class="bubblelink code" onclick="return showCourse(this, '5.13');">5.13</a>, <a href="/search/?P=7.06" title="7.06" class="bubblelink code" onclick="return showCourse(this, '7.06');">7.06</a>, and permission of instructor </span><br/><span class="courseblockterms">G (Fall)</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">See description under subject <a href="/search/?P=5.54J" title="5.54[J]" class="bubblelink code" onclick="return showCourse(this, '5.54J');">5.54[J]</a>. </p> <p class="courseblockinstructors seemore"><span><i>L. Kiessling, M. Shoulders</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.546[J] Science and Business of Biotechnology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=15.480J" title="15.480[J]" class="bubblelink code" onclick="return showCourse(this, '15.480J');">15.480[J]</a>, <a href="/search/?P=20.586J" title="20.586[J]" class="bubblelink code" onclick="return showCourse(this, '20.586J');">20.586[J]</a></span><br/><span class="courseblockprereq">Prereq: None. <i>Coreq: <a href="/search/?P=15.401" title="15.401" class="bubblelink code" onclick="return showCourse(this, '15.401');">15.401</a></i>; permission of instructor </span><br/><span class="courseblockterms">G (Spring)</span><br/><span class="courseblockhours">3-0-6 units</span> </p> <p class="courseblockdesc">Covers the new types of drugs and other therapeutics in current practice and under development, the financing and business structures of early-stage biotechnology companies, and the evaluation of their risk/reward profiles. Includes a series of live case studies with industry leaders of both established and emerging biotechnology companies as guest speakers, focusing on the underlying science and engineering as well as core financing and business issues. Students must possess a basic background in cellular and molecular biology. </p> <p class="courseblockinstructors seemore"><span><i>J. Chen, A. Koehler, A. Lo, H. Lodish</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.548[J] Advances in Biomanufacturing</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=10.53J" title="10.53[J]" class="bubblelink code" onclick="return showCourse(this, '10.53J');">10.53[J]</a><br/> Subject meets with <a href="/search/?P=7.458J" title="7.458[J]" class="bubblelink code" onclick="return showCourse(this, '7.458J');">7.458[J]</a>, <a href="/search/?P=10.03J" title="10.03[J]" class="bubblelink code" onclick="return showCourse(this, '10.03J');">10.03[J]</a></span><br/><span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">G (Spring; second half of term)</span><br/><span class="courseblockhours">1-0-2 units</span> </p> <p class="courseblockdesc">Seminar examines how biopharmaceuticals, an increasingly important class of pharmaceuticals, are manufactured. Topics range from fundamental bioprocesses to new technologies to the economics of biomanufacturing. Also covers the impact of globalization on regulation and quality approaches as well as supply chain integrity. Students taking graduate version complete additional assignments. </p> <p class="courseblockinstructors seemore"><span><i>J. C. Love, A. Sinskey, S. Springs</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.549[J] Case Studies and Strategies in Drug Discovery and Development</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=15.137J" title="15.137[J]" class="bubblelink code" onclick="return showCourse(this, '15.137J');">15.137[J]</a>, <a href="/search/?P=20.486J" title="20.486[J]" class="bubblelink code" onclick="return showCourse(this, '20.486J');">20.486[J]</a>, <a href="/search/?P=HST.916J" title="HST.916[J]" class="bubblelink code" onclick="return showCourse(this, 'HST.916J');">HST.916[J]</a></span><br/><span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">G (Spring)<br/> Not offered regularly; consult department</span><br/><span class="courseblockhours">2-0-4 units</span> </p> <p class="courseblockdesc">See description under subject <a href="/search/?P=20.486J" title="20.486[J]" class="bubblelink code" onclick="return showCourse(this, '20.486J');">20.486[J]</a>. </p> <p class="courseblockinstructors seemore"><span><i>A. W. Wood</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.55 Case Studies in Modern Experimental Design</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Spring)</span><br/><span class="courseblockhours">2-0-7 units</span> </p> <p class="courseblockdesc">Focuses on enhancing students' ability to analyze, design and present experiments, emphasizing modern techniques. Class discussions begin with papers that developed or utilized contemporary approaches (e.g., quantitative microscopy, biophysical and molecular genetic methods) to address important problems in biology. Each student prepares one specific aim of a standard research proposal for a project that emphasizes research strategy, experimental design, and writing. </p> <p class="courseblockinstructors seemore"><span><i>L. Guarente, A. Ringel</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.571 Quantitative Analysis of Biological Data</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">G (Spring; first half of term)</span><br/><span class="courseblockhours">2-0-4 units</span> </p> <p class="courseblockdesc">Application of probability theory and statistical methods to analyze biological data. Topics include: descriptive and inferential statistics, an introduction to Bayesian statistics, design of quantitative experiments,聽and methods to analyze high-dimensional datasets. A聽<em>conceptual</em> understanding of topics is emphasized, and methods are illustrated using the Python programming language. Although a basic understanding of Python is encouraged, no programming experience is required. Students taking the graduate version are expected to explore the subject in greater depth. </p> <p class="courseblockinstructors seemore"><span><i>J. Davis聽</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.572 Quantitative Measurements and Modeling of Biological Systems</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">G (Spring; second half of term)</span><br/><span class="courseblockhours">2-0-4 units</span> </p> <p class="courseblockdesc">Quantitative experimental design, data analysis, and modeling for biological systems. Topics include absolute/relative quantification,聽noise and reproducibility, regression and correlation, and modeling of population growth, gene expression, cellular dynamics, feedback regulation, oscillation. Students taking the graduate version are expected to explore the subject in greater depth. </p> <p class="courseblockinstructors seemore"><span><i>G. W. Li</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.573 Modern Biostatistics</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with <a href="/search/?P=7.093" title="7.093" class="bubblelink code" onclick="return showCourse(this, '7.093');">7.093</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=7.03" title="7.03" class="bubblelink code" onclick="return showCourse(this, '7.03');">7.03</a> and <a href="/search/?P=7.05" title="7.05" class="bubblelink code" onclick="return showCourse(this, '7.05');">7.05</a> </span><br/><span class="courseblockterms">G (Spring; first half of term)</span><br/><span class="courseblockhours">2-0-4 units</span> </p> <p class="courseblockdesc">Provides a practical introduction to probability and statistics used in modern biology. Topics covered include discrete and continuous probability distributions, statistical modeling, hypothesis testing, independence, conditional probability, multiple test corrections, nonparametric methods, clustering, correlation, linear regression, principal components analysis with applications to high-throughput DNA sequencing and image data analysis. Homework is in the R programming language, but prior programming experience is not required. Students taking the graduate version are expected to explore the subject in greater depth. </p> <p class="courseblockinstructors seemore"><span><i>A. Jain, H. Wong</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.574 Modern Computational Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with <a href="/search/?P=7.094" title="7.094" class="bubblelink code" onclick="return showCourse(this, '7.094');">7.094</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=7.03" title="7.03" class="bubblelink code" onclick="return showCourse(this, '7.03');">7.03</a> and <a href="/search/?P=7.05" title="7.05" class="bubblelink code" onclick="return showCourse(this, '7.05');">7.05</a> </span><br/><span class="courseblockterms">G (Spring; second half of term)</span><br/><span class="courseblockhours">2-0-4 units</span> </p> <p class="courseblockdesc">Introduces modern methods in computational biology, focusing on DNA/RNA/protein analysis. Topics include next-generation DNA sequencing and sequencing data analysis, RNA-seq (bulk and single-cell), and protein dynamics. Students taking the graduate version are expected to explore the subject in greater depth. </p> <p class="courseblockinstructors seemore"><span><i>A, Jain, H. Wong</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.58 Molecular Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with <a href="/search/?P=7.28" title="7.28" class="bubblelink code" onclick="return showCourse(this, '7.28');">7.28</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=7.03" title="7.03" class="bubblelink code" onclick="return showCourse(this, '7.03');">7.03</a>, <a href="/search/?P=7.05" title="7.05" class="bubblelink code" onclick="return showCourse(this, '7.05');">7.05</a>, and permission of instructor </span><br/><span class="courseblockterms">G (Spring)</span><br/><span class="courseblockhours">5-0-7 units</span> </p> <p class="courseblockdesc">Detailed analysis of the biochemical mechanisms that control the maintenance, expression, and evolution of prokaryotic and eukaryotic genomes. Topics covered in lecture and readings of relevant literature include: gene regulation, DNA replication, genetic recombination, and mRNA translation. Logic of experimental design and data analysis emphasized. Presentations include both lectures and group discussions of representative papers from the literature. Students taking the graduate version are expected to explore the subject in greater depth. </p> <p class="courseblockinstructors seemore"><span><i>E. Calo, Y. Soto-Feliciano</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.59[J] Teaching College-Level Science and Engineering</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=1.95J" title="1.95[J]" class="bubblelink code" onclick="return showCourse(this, '1.95J');">1.95[J]</a>, <a href="/search/?P=5.95J" title="5.95[J]" class="bubblelink code" onclick="return showCourse(this, '5.95J');">5.95[J]</a>, <a href="/search/?P=8.395J" title="8.395[J]" class="bubblelink code" onclick="return showCourse(this, '8.395J');">8.395[J]</a>, <a href="/search/?P=18.094J" title="18.094[J]" class="bubblelink code" onclick="return showCourse(this, '18.094J');">18.094[J]</a><br/> Subject meets with <a href="/search/?P=2.978" title="2.978" class="bubblelink code" onclick="return showCourse(this, '2.978');">2.978</a></span><br/><span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">G (Fall)</span><br/><span class="courseblockhours">2-0-2 units</span> </p> <p class="courseblockdesc">See description under subject <a href="/search/?P=5.95J" title="5.95[J]" class="bubblelink code" onclick="return showCourse(this, '5.95J');">5.95[J]</a>. </p> <p class="courseblockinstructors seemore"><span><i>J. Rankin</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.60 Cell Biology: Structure and Functions of the Nucleus</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: <a href="/search/?P=7.06" title="7.06" class="bubblelink code" onclick="return showCourse(this, '7.06');">7.06</a> or permission of instructor </span><br/><span class="courseblockterms">G (Spring)</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">Eukaryotic genome structure, function, and expression, processing of RNA, and regulation of the cell cycle. Emphasis on the techniques and logic used to address important problems in nuclear cell biology. Lectures on broad topic areas in nuclear cell biology and discussions on representative recent papers. </p> <p class="courseblockinstructors seemore"><span><i>L. Boyer, R. Young</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.61[J] Eukaryotic Cell Biology: Principles and Practice</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=20.561J" title="20.561[J]" class="bubblelink code" onclick="return showCourse(this, '20.561J');">20.561[J]</a></span><br/><span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">Acad Year 2024-2025: Not offered<br/> Acad Year 2025-2026: G (Fall)</span><br/><span class="courseblockhours">4-0-8 units</span> </p> <p class="courseblockdesc">Emphasizes methods and logic used to analyze structure and function of eukaryotic cells in diverse systems (e.g., yeast, fly, worm, mouse, human; development, stem cells, neurons). Combines lectures and in-depth roundtable discussions of literature readings with the active participation of faculty experts. Focuses on membranes (structure, function, traffic), organelles, the cell surface, signal transduction, cytoskeleton, cell motility and extracellular matrix. Ranges from basic studies to applications to human disease, while stressing critical analysis of experimental approaches. Enrollment limited.</p> <p class="courseblockinstructors seemore"><span><i>M. Krieger, M. Yaffe</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.62 Microbial Physiology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with <a href="/search/?P=7.21" title="7.21" class="bubblelink code" onclick="return showCourse(this, '7.21');">7.21</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=7.03" title="7.03" class="bubblelink code" onclick="return showCourse(this, '7.03');">7.03</a>, <a href="/search/?P=7.05" title="7.05" class="bubblelink code" onclick="return showCourse(this, '7.05');">7.05</a>, and permission of instructor </span><br/><span class="courseblockterms">G (Fall)</span><br/><span class="courseblockhours">4-0-8 units</span> </p> <p class="courseblockdesc">Biochemical properties of bacteria and other microorganisms that enable them to grow under a variety of conditions. Interaction between bacteria and bacteriophages. Genetic and metabolic regulation of enzyme action and enzyme formation. Structure and function of components of the bacterial cell envelope. Protein secretion with a special emphasis on its various roles in pathogenesis. Additional topics include bioenergetics, symbiosis, quorum sensing, global responses to DNA damage, and biofilms. Students taking the graduate version are expected to explore the subject in greater depth. </p> <p class="courseblockinstructors seemore"><span><i>G. C. Walker, A. J. Sinskey</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.63[J] Immunology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=20.630J" title="20.630[J]" class="bubblelink code" onclick="return showCourse(this, '20.630J');">20.630[J]</a><br/> Subject meets with <a href="/search/?P=7.23J" title="7.23[J]" class="bubblelink code" onclick="return showCourse(this, '7.23J');">7.23[J]</a>, <a href="/search/?P=20.230J" title="20.230[J]" class="bubblelink code" onclick="return showCourse(this, '20.230J');">20.230[J]</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=7.06" title="7.06" class="bubblelink code" onclick="return showCourse(this, '7.06');">7.06</a> and permission of instructor </span><br/><span class="courseblockterms">G (Spring)</span><br/><span class="courseblockhours">5-0-7 units</span> </p> <p class="courseblockdesc">Comprehensive survey of molecular, genetic, and cellular aspects of the immune system. Topics include innate and adaptive immunity; cells and organs of the immune system; hematopoiesis; immunoglobulin, T cell receptor, and major histocompatibility complex (MHC) proteins and genes; development and functions of B and T lymphocytes; immune responses to infections and tumors; hypersensitivity, autoimmunity, and immunodeficiencies. Particular attention to the development and function of the immune system as a whole, as studied by modern methods and techniques. Students taking graduate version explore the subject in greater depth, including study of recent primary literature. </p> <p class="courseblockinstructors seemore"><span><i>S. Spranger, M. Birnbaum</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.64 Molecular Mechanisms, Pathology and Therapy of Human Neuromuscular Disorders</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">Acad Year 2024-2025: Not offered<br/> Acad Year 2025-2026: G (Spring)</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">Investigates the molecular and clinical basis of central nervous system and neuromuscular disorders with particular emphasis on strategies for therapeutic intervention. Considers the in-depth analysis of clinical features, pathological mechanisms, and responses to current therapeutic interventions. Covers neurodegenerative diseases, such as Huntington's disease, Parkinson's disease, Alzheimer's disease, Amyotropic Lateral Schlerosis, Frontal Temporal Dementia, and neuromuscular disorders, such as Myotonic Dystrophy, Facio Scapular Humoral Dystrophy, and Duchenne Muscular Dystrophy. </p> <p class="courseblockinstructors seemore"><span><i>D. Housman</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.65[J] Molecular and Cellular Neuroscience Core I</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=9.015J" title="9.015[J]" class="bubblelink code" onclick="return showCourse(this, '9.015J');">9.015[J]</a></span><br/><span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">G (Fall)</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">See description under subject <a href="/search/?P=9.015J" title="9.015[J]" class="bubblelink code" onclick="return showCourse(this, '9.015J');">9.015[J]</a>. </p> <p class="courseblockinstructors seemore"><span><i>J. T. Littleton, M. Sheng, B. Weissbourd</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.66 Molecular Basis of Infectious Disease</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with <a href="/search/?P=7.26" title="7.26" class="bubblelink code" onclick="return showCourse(this, '7.26');">7.26</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=7.06" title="7.06" class="bubblelink code" onclick="return showCourse(this, '7.06');">7.06</a> and permission of instructor </span><br/><span class="courseblockterms">G (Spring)</span><br/><span class="courseblockhours">4-0-8 units</span> </p> <p class="courseblockdesc">Focuses on the principles of host-pathogen interactions with an emphasis on infectious diseases of humans. Presents key concepts of pathogenesis through the study of various human pathogens. Includes critical analysis and discussion of assigned readings. Students taking the graduate version are expected to explore the subject in greater depth. </p> <p class="courseblockinstructors seemore"><span><i>E. Chen, R. Lamason</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.68[J] Molecular and Cellular Neuroscience Core II</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=9.013J" title="9.013[J]" class="bubblelink code" onclick="return showCourse(this, '9.013J');">9.013[J]</a></span><br/><span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Spring)<br/> Not offered regularly; consult department</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">See description under subject <a href="/search/?P=9.013J" title="9.013[J]" class="bubblelink code" onclick="return showCourse(this, '9.013J');">9.013[J]</a>. </p> <p class="courseblockinstructors seemore"><span><i>G. Feng, L.-H. Tsai</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.69[J] Developmental Neurobiology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=9.181J" title="9.181[J]" class="bubblelink code" onclick="return showCourse(this, '9.181J');">9.181[J]</a><br/> Subject meets with <a href="/search/?P=7.49J" title="7.49[J]" class="bubblelink code" onclick="return showCourse(this, '7.49J');">7.49[J]</a>, <a href="/search/?P=9.18J" title="9.18[J]" class="bubblelink code" onclick="return showCourse(this, '9.18J');">9.18[J]</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=9.011" title="9.011" class="bubblelink code" onclick="return showCourse(this, '9.011');">9.011</a> or permission of instructor </span><br/><span class="courseblockterms">G (Spring)</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">See description under subject <a href="/search/?P=9.181J" title="9.181[J]" class="bubblelink code" onclick="return showCourse(this, '9.181J');">9.181[J]</a>. </p> <p class="courseblockinstructors seemore"><span><i>E. Nedivi, M. Heiman</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.70 Regulation of Gene Expression</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">Acad Year 2024-2025: Not offered<br/> Acad Year 2025-2026: G (Spring)</span><br/><span class="courseblockhours">4-0-8 units</span> </p> <p class="courseblockdesc">Seminar examines basic principles of biological regulation of gene expression. Focuses on examples that underpin these principles, as well as those that challenge certain long-held views. Topics covered may include the role of transcription factors, enhancers, DNA modifications, non-coding RNAs, and chromatin structure in the regulation of gene expression and mechanisms for epigenetic inheritance of transcriptional states. Limited to 40.</p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.71 Biophysical Technique</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with <a href="/search/?P=5.78" title="5.78" class="bubblelink code" onclick="return showCourse(this, '5.78');">5.78</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=5.13" title="5.13" class="bubblelink code" onclick="return showCourse(this, '5.13');">5.13</a>, 5.60, (<a href="/search/?P=5.07" title="5.07[J]" class="bubblelink code" onclick="return showCourse(this, '5.07');">5.07[J]</a> or <a href="/search/?P=7.05" title="7.05" class="bubblelink code" onclick="return showCourse(this, '7.05');">7.05</a>), and permission of instructor </span><br/><span class="courseblockterms">G (Spring)</span><br/><span class="courseblockhours">5-0-7 units</span> </p> <p class="courseblockdesc">Introduces students to modern biophysical methods to study biological systems from atomic, to molecular and cellular scales. Includes an in-depth discussion on the techniques that cover the full resolution range, including X-ray crystallography, electron-, and light microscopy. Discusses other common biophysical techniques for macromolecular characterizations. Lectures cover theoretical principles behind the techniques, and students are given practical laboratory exercises using instrumentation available at MIT. Meets with <a href="/search/?P=5.78" title="5.78" class="bubblelink code" onclick="return showCourse(this, '5.78');">5.78</a> when offered concurrently.聽 </p> <p class="courseblockinstructors seemore"><span><i>C. Drennan, T. Schwartz</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.72 Stem Cells, Regeneration, and Development</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Spring)</span><br/><span class="courseblockhours">4-0-8 units</span> </p> <p class="courseblockdesc">Topics include diverse stem cells, such as muscle, intestine, skin, hair and hematopoietic stem cells, as well as pluripotent stem cells. Topics address cell polarity and cell fate; positional information and patterning of development and regeneration; limb, heart and whole body regeneration; stem cell renewal; progenitor cells in development; responses to wounding; and applications of stem cells in development of therapies. Discussions of papers supplement lectures. </p> <p class="courseblockinstructors seemore"><span><i>R. Jaenisch, P. Reddien</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.73 Principles of Chemical Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: <a href="/search/?P=7.05" title="7.05" class="bubblelink code" onclick="return showCourse(this, '7.05');">7.05</a> and permission of instructor </span><br/><span class="courseblockterms">Acad Year 2024-2025: Not offered<br/> Acad Year 2025-2026: G (Spring)</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">Spanning the fields of biology, chemistry and engineering, class addresses the principles of chemical biology and its application of chemical and physical methods and reagents to the study and manipulation of biological systems. Topics include bioorthogonal reactions and activity-based protein profiling, small molecule inhibitors and chemical genetics, fluorescent probes for biological studies, and unnatural amino acid mutagenesis. Also covers chemical biology approaches for studying dynamic post-translational modification reactions, natural product biosynthesis and mutasynthesis, and high-throughput drug screening. Students taking the graduate version are expected to explore the subject in greater depth. </p> <p class="courseblockinstructors seemore"><span><i>B. Imperiali, J. K. Weng</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.74[J] Topics in Biophysics and Physical Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=8.590J" title="8.590[J]" class="bubblelink code" onclick="return showCourse(this, '8.590J');">8.590[J]</a>, <a href="/search/?P=20.416J" title="20.416[J]" class="bubblelink code" onclick="return showCourse(this, '20.416J');">20.416[J]</a></span><br/><span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">Acad Year 2024-2025: Not offered<br/> Acad Year 2025-2026: G (Fall)</span><br/><span class="courseblockhours">2-0-4 units</span> </p> <p class="courseblockdesc">Provides broad exposure to research in biophysics and physical biology, with emphasis on the critical evaluation of scientific literature. Weekly meetings include in-depth discussion of scientific literature led by distinct faculty on active research topics. Each session also includes brief discussion of non-research topics including effective presentation skills, writing papers and fellowship proposals, choosing scientific and technical research topics, time management, and scientific ethics. </p> <p class="courseblockinstructors seemore"><span><i>J. Gore, N. Fakhri</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.75 Human Genetics and Genomics</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with <a href="/search/?P=7.35" title="7.35" class="bubblelink code" onclick="return showCourse(this, '7.35');">7.35</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=7.52" title="7.52" class="bubblelink code" onclick="return showCourse(this, '7.52');">7.52</a> or permission of instructor </span><br/><span class="courseblockterms">G (Spring)</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">Upper level seminar offering in-depth analysis and engaged discussion of primary literature on the dimensions and phenotypic consequences of variation in human genes, chromosomes, and genomes.聽 Topics include the human genome project; pedigree analysis; mutation and selection; linkage and association studies; medical genetics and disease; sex chromosomes and sex differences; the biology of the germ line; epigenetics, imprinting, and transgenerational inheritance; human origins; and evolutionary and population genetics. Students taking graduate version complete additional assignments. Limited to 20 total for versions meeting together.</p> <p class="courseblockinstructors seemore"><span><i>D. Page</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.76 Topics in Macromolecular Structure and Function</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">Acad Year 2024-2025: Not offered<br/> Acad Year 2025-2026: G (Spring)</span><br/><span class="courseblockhours">3-0-6 units</span> </p> <p class="courseblockdesc">In-depth analysis and discussion of classic and current literature, with an emphasis on the structure, function, and mechanisms of proteins and other biological macromolecules. </p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.77 Nucleic Acids, Structure, Function, Evolution, and Their Interactions with Proteins</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: <a href="/search/?P=7.05" title="7.05" class="bubblelink code" onclick="return showCourse(this, '7.05');">7.05</a>, <a href="/search/?P=7.51" title="7.51" class="bubblelink code" onclick="return showCourse(this, '7.51');">7.51</a>, or permission of instructor </span><br/><span class="courseblockterms">G (Spring)</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">Surveys primary literature, focusing on biochemical, biophysical, genetic, and combinatorial approaches for understanding nucleic acids. Topics include the general properties, functions, and structural motifs of DNA and RNA; RNAs as catalysts and as regulators of gene expression; RNA editing and surveillance, and the interaction of nucleic acids with proteins, such as zinc-finger proteins, modification enzymes, aminoacyl-tRNA synthetases and other proteins of the translational machinery. Includes some lectures but is mostly analysis and discussion of current literature in the context of student presentations. </p> <p class="courseblockinstructors seemore"><span><i>D. Bartel, A. Jain</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.80 Fundamentals of Chemical Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with <a href="/search/?P=5.08J" title="5.08[J]" class="bubblelink code" onclick="return showCourse(this, '5.08J');">5.08[J]</a>, <a href="/search/?P=7.08J" title="7.08[J]" class="bubblelink code" onclick="return showCourse(this, '7.08J');">7.08[J]</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=5.13" title="5.13" class="bubblelink code" onclick="return showCourse(this, '5.13');">5.13</a> and (<a href="/search/?P=5.07" title="5.07[J]" class="bubblelink code" onclick="return showCourse(this, '5.07');">5.07[J]</a> or <a href="/search/?P=7.05" title="7.05" class="bubblelink code" onclick="return showCourse(this, '7.05');">7.05</a>) </span><br/><span class="courseblockterms">G (Spring)</span><br/><span class="courseblockhours">4-0-8 units</span> </p> <p class="courseblockdesc">Spanning the fields of biology, chemistry, and engineering, this class introduces students to the principles of chemical biology and the application of chemical and physical methods and reagents to the study and manipulation of biological systems. Topics include nucleic acid structure, recognition, and manipulation; protein folding and stability, and proteostasis; bioorthogonal reactions and activity-based protein profiling; chemical genetics and small-molecule inhibitor screening; fluorescent probes for biological analysis and imaging; and unnatural amino acid mutagenesis. The class will also discuss the logic of dynamic post-translational modification reactions with an emphasis on chemical biology approaches for studying complex processes including glycosylation, phosphorylation, and lipidation. Students taking the graduate version are expected to explore the subject in greater depth. </p> <p class="courseblockinstructors seemore"><span><i>B. Imperiali, R. Raines</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.81[J] Systems Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=8.591J" title="8.591[J]" class="bubblelink code" onclick="return showCourse(this, '8.591J');">8.591[J]</a><br/> Subject meets with <a href="/search/?P=7.32" title="7.32" class="bubblelink code" onclick="return showCourse(this, '7.32');">7.32</a></span><br/><span class="courseblockprereq">Prereq: (<a href="/search/?P=18.03" title="18.03" class="bubblelink code" onclick="return showCourse(this, '18.03');">18.03</a> and <a href="/search/?P=18.05" title="18.05" class="bubblelink code" onclick="return showCourse(this, '18.05');">18.05</a>) or permission of instructor </span><br/><span class="courseblockterms">G (Fall)</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">See description under subject <a href="/search/?P=8.591J" title="8.591[J]" class="bubblelink code" onclick="return showCourse(this, '8.591J');">8.591[J]</a>. </p> <p class="courseblockinstructors seemore"><span><i>J. Gore</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.82 Development, Disease and Therapeutics</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Spring)</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">Seminar covering the key concepts and technological approaches that are used to study and treat human disease. Topics include human genome variation, germline editing, gene therapy, stem cell derived organoids, human-animal chimeras and the application of these approaches to the study and treatment of major diseases. </p> <p class="courseblockinstructors seemore"><span><i>R. Jaenisch, R. Young</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.83 Design Principles of Biological Systems</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with <a href="/search/?P=7.38" title="7.38" class="bubblelink code" onclick="return showCourse(this, '7.38');">7.38</a></span><br/><span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Fall)</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">Introduces students to biological control mechanisms governing decision-making and tools to decipher, model, and perturb these mechanisms. Systems presented include signal transduction, cell cycle control, developmental biology, and the immune system. These systems provide examples of feedback and feedforward control, oscillators, kinetic proofreading, spatial and temporal averaging, and pattern formation. Students taking graduate version complete additional assignments. </p> <p class="courseblockinstructors seemore"><span><i>D. Lew, H. Wong</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.84 Advanced Concepts in Immunology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with <a href="/search/?P=7.24" title="7.24" class="bubblelink code" onclick="return showCourse(this, '7.24');">7.24</a></span><br/><span class="courseblockprereq">Prereq: None. <i>Coreq: <a href="/search/?P=7.63" title="7.63[J]" class="bubblelink code" onclick="return showCourse(this, '7.63');">7.63[J]</a></i>; or permission of instructor </span><br/><span class="courseblockterms">G (Spring)</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">Provides a comprehensive and intensified understanding of the relevance of the immune system beyond immunity. Focuses on how the immune system intersects with all aspects of body homeostasis/physiology or disease and how the immune system can be manipulated therapeutically. New advances in the intersection of immunology with cancer biology, neurosciences, metabolism, aging, and maternal-fetal immunology or similar explored. Presents new modern methods and techniques applicable beyond immunology. Includes critical analysis and discussion of assigned readings. Students apply principles learned in class to generate a potential research project, presented in a written form. Students taking graduate version complete additional assignments. </p> <p class="courseblockinstructors seemore"><span><i>H. Moura Silva, S. Spranger</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.85 The Hallmarks of Cancer</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with <a href="/search/?P=7.45" title="7.45" class="bubblelink code" onclick="return showCourse(this, '7.45');">7.45</a></span><br/><span class="courseblockprereq">Prereq: None. <i>Coreq: <a href="/search/?P=7.06" title="7.06" class="bubblelink code" onclick="return showCourse(this, '7.06');">7.06</a></i>; permission of instructor </span><br/><span class="courseblockterms">G (Fall)</span><br/><span class="courseblockhours">4-0-8 units</span> </p> <p class="courseblockdesc">Provides a comprehensive introduction to the fundamentals of cancer biology and cancer treatment. Topics include cancer genetics, genomics, and epigenetics; familial cancer syndromes; signal transduction, cell cycle control, and apoptosis; cancer metabolism; stem cells and cancer; metastasis; cancer immunology and immunotherapy; conventional and molecularly-targeted therapies; and early detection and prevention. Students taking graduate version complete additional assignments. </p> <p class="courseblockinstructors seemore"><span><i>M. Hemann, T. Jacks</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.86 Building with Cells</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with <a href="/search/?P=7.46" title="7.46" class="bubblelink code" onclick="return showCourse(this, '7.46');">7.46</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=7.03" title="7.03" class="bubblelink code" onclick="return showCourse(this, '7.03');">7.03</a> and <a href="/search/?P=7.05" title="7.05" class="bubblelink code" onclick="return showCourse(this, '7.05');">7.05</a> </span><br/><span class="courseblockterms">G (Fall)</span><br/><span class="courseblockhours">4-0-8 units</span> </p> <p class="courseblockdesc">Focuses on fundamental principles of developmental biology by which cells build organs and organisms. Analyzes the pivotal role of stem cells in tissue maintenance or repair, and in treatment of disease. Explores how to integrate this聽knowledge with engineering tools to construct functional tissue structures.聽Students taking graduate version complete additional assignments. </p> <p class="courseblockinstructors seemore"><span><i>L. Boyer, P. Li</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.88[J] Protein Folding in Health and Disease</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=5.48J" title="5.48[J]" class="bubblelink code" onclick="return showCourse(this, '5.48J');">5.48[J]</a></span><br/><span class="courseblockprereq">Prereq: (<a href="/search/?P=5.07" title="5.07[J]" class="bubblelink code" onclick="return showCourse(this, '5.07');">5.07[J]</a> or <a href="/search/?P=7.05" title="7.05" class="bubblelink code" onclick="return showCourse(this, '7.05');">7.05</a>) and permission of instructor </span><br/><span class="courseblockterms">Acad Year 2024-2025: Not offered<br/> Acad Year 2025-2026: G (Spring; first half of term)</span><br/><span class="courseblockhours">3-0-3 units</span> </p> <p class="courseblockdesc">See description under subject <a href="/search/?P=5.48J" title="5.48[J]" class="bubblelink code" onclick="return showCourse(this, '5.48J');">5.48[J]</a>. </p> <p class="courseblockinstructors seemore"><span><i>M. Shoulders</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.89[J] Topics in Computational and Systems Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=CSB.100J" title="CSB.100[J]" class="bubblelink code" onclick="return showCourse(this, 'CSB.100J');">CSB.100[J]</a></span><br/><span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Fall)</span><br/><span class="courseblockhours">2-0-10 units</span> </p> <p class="courseblockdesc">See description under subject <a href="/search/?P=CSB.100J" title="CSB.100[J]" class="bubblelink code" onclick="return showCourse(this, 'CSB.100J');">CSB.100[J]</a>. Preference to first-year CSB PhD students.</p> <p class="courseblockinstructors seemore"><span><i>C. Burge</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.91 The CRISPR Revolution: Engineering the Genome for Basic Science and Clinical Medicine</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with <a href="/search/?P=7.36" title="7.36" class="bubblelink code" onclick="return showCourse(this, '7.36');">7.36</a></span><br/><span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Fall)</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">Provides a conceptual and technical understanding of genome editing systems and their research and clinical applications. Focuses on fundamental CRISPR biology in bacteria, methodologies for manipulating the genome with CRISPR, and the application of genome engineering in research and medicine. Combines lectures and literature discussions with critical analysis and assigned readings, with the goal of better understanding how key discoveries were made and how these are applied in the real work. Class work includes brief writing assignments as well as a final research proposal and scientific presentation. Students taking the graduate version explore the subject in greater depth, in part through additional assignments. </p> <p class="courseblockinstructors seemore"><span><i>F. S谩nchez-Rivera, J. Weissman</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.930[J] Research Experience in Biopharma</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=20.930J" title="20.930[J]" class="bubblelink code" onclick="return showCourse(this, '20.930J');">20.930[J]</a>, <a href="/search/?P=CSB.930J" title="CSB.930[J]" class="bubblelink code" onclick="return showCourse(this, 'CSB.930J');">CSB.930[J]</a></span><br/><span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">G (Fall)</span><br/><span class="courseblockhours">2-10-0 units</span> </p> <p class="courseblockdesc">See description under subject <a href="/search/?P=20.930J" title="20.930[J]" class="bubblelink code" onclick="return showCourse(this, '20.930J');">20.930[J]</a>. </p> <p class="courseblockinstructors seemore"><span><i>C. Burge</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.931 Independent Study in Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">Acad Year 2024-2025: G (Fall, Spring)<br/> Acad Year 2025-2026: Not offered</span><br/><span class="courseblockhours">Units arranged [P/D/F]</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Program of study or research to be arranged with a department faculty member. </p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.932 Independent Study in Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">Acad Year 2024-2025: G (Fall, Spring)<br/> Acad Year 2025-2026: Not offered</span><br/><span class="courseblockhours">Units arranged</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Program of study or research to be arranged with a department faculty member. </p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.933 Research Rotations in Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Fall, Spring)</span><br/><span class="courseblockhours">Units arranged [P/D/F]</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Introduces students to faculty participating in the Biology graduate program through a series of lab rotations, which provide broad exposure to biology research at MIT. Students select a lab for thesis research by the end of their first year. Limited to students in the Biology graduate program.</p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.934 Teaching Experience in Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Fall, IAP, Spring)</span><br/><span class="courseblockhours">Units arranged [P/D/F]</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">For qualified graduate students in the Biology graduate program interested in teaching. Classroom or laboratory teaching under the supervision of a faculty member. </p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.935 Responsible Conduct in Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Fall, IAP, Spring, Summer)</span><br/><span class="courseblockhours">Units arranged [P/D/F]</span> </p> <p class="courseblockdesc">Sessions focus on the responsible conduct of science. Considers recordkeeping and reporting; roles of mentor and mentee; authorship, review, and confidentiality; resolving conflicts; misfeasance and malfeasance; collaborations, competing interests, and intellectual property; and proper practices in the use of animal and human subjects. Limited to second-year graduate students in Biology.</p> <p class="courseblockinstructors seemore"><span><i>S. Hrvatin, Y. Yamashita</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.936 Professional Development in Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">G (Fall, IAP, Spring, Summer)</span><br/><span class="courseblockhours">0-2-0 units</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Required for course 7 doctoral students to gain professional perspective in career development activities such as internships, scientific meetings, and career and networking events. Written report required upon completion of activities. </p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.941 Research Problems</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Fall, Summer)</span><br/><span class="courseblockhours">Units arranged [P/D/F]</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Directed research in a field of biological science, but not contributory to graduate thesis. </p> <p class="courseblockinstructors seemore"><span><i>Consult Biology Education Office</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.942 Research Problems</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Spring)</span><br/><span class="courseblockhours">Units arranged [P/D/F]</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Directed research in a field of biological science, but not contributory to graduate thesis. </p> <p class="courseblockinstructors seemore"><span><i>Consult Biology Education Office</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.95 Cancer Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: <a href="/search/?P=7.85" title="7.85" class="bubblelink code" onclick="return showCourse(this, '7.85');">7.85</a> and permission of instructor </span><br/><span class="courseblockterms">G (Spring)</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">Advanced seminar involving intensive analysis of historical and current developments in cancer biology. Topics address principles of apoptosis, principles of cancer biology, cancer genetics, cancer cell metabolism, tumor immunology, and therapy. Detailed analysis of research literature, including important reports published in recent years. Enrollment limited.</p> <p class="courseblockinstructors seemore"><span><i>R. Weinberg, O. Yilmaz</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.98[J] Neural Plasticity in Learning and Memory</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=9.301J" title="9.301[J]" class="bubblelink code" onclick="return showCourse(this, '9.301J');">9.301[J]</a></span><br/><span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Spring)<br/> Not offered regularly; consult department</span><br/><span class="courseblockhours">3-0-6 units</span> </p> <p class="courseblockdesc">See description under subject <a href="/search/?P=9.301J" title="9.301[J]" class="bubblelink code" onclick="return showCourse(this, '9.301J');">9.301[J]</a>. Juniors and seniors require instructor's permission.</p> <p class="courseblockinstructors seemore"><span><i>S. Tonegawa</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.C51 Machine Learning in Molecular and Cellular Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with <a href="/search/?P=3.C01J" title="3.C01[J]" class="bubblelink code" onclick="return showCourse(this, '3.C01J');">3.C01[J]</a>, <a href="/search/?P=3.C51J" title="3.C51[J]" class="bubblelink code" onclick="return showCourse(this, '3.C51J');">3.C51[J]</a>, <a href="/search/?P=7.C01" title="7.C01" class="bubblelink code" onclick="return showCourse(this, '7.C01');">7.C01</a>, <a href="/search/?P=10.C01J" title="10.C01[J]" class="bubblelink code" onclick="return showCourse(this, '10.C01J');">10.C01[J]</a>, <a href="/search/?P=10.C51J" title="10.C51[J]" class="bubblelink code" onclick="return showCourse(this, '10.C51J');">10.C51[J]</a>, <a href="/search/?P=20.C01J" title="20.C01[J]" class="bubblelink code" onclick="return showCourse(this, '20.C01J');">20.C01[J]</a>, <a href="/search/?P=20.C51J" title="20.C51[J]" class="bubblelink code" onclick="return showCourse(this, '20.C51J');">20.C51[J]</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=7.012|7.013|7.014|7.015|7.016" onclick="return showCourse(this, '7.012|7.013|7.014|7.015|7.016');">Biology (GIR)</a>, <a href="/search/?P=6.100A" title="6.100A" class="bubblelink code" onclick="return showCourse(this, '6.100A');">6.100A</a>, <a href="/search/?P=6.C51" title="6.C51" class="bubblelink code" onclick="return showCourse(this, '6.C51');">6.C51</a>, and <a href="/search/?P=7.05" title="7.05" class="bubblelink code" onclick="return showCourse(this, '7.05');">7.05</a> </span><br/><span class="courseblockterms">G (Spring)</span><br/><span class="courseblockhours">2-0-4 units</span> </p> <p class="courseblockdesc">Introduces machine learning as a tool to understand natural biological systems, with an evolving emphasis on problems in molecular and cellular biology that are being actively advanced using machine learning. Students design, implement, and interpret machine learning approaches to aid in predicting protein structure, probing protein structure/function relationships, and imaging biological systems at scales ranging from the atomic to cellular. Students taking graduate version complete an additional project-based assignment. Students cannot receive credit without completion of the core subject <a href="/search/?P=6.C51" title="6.C51" class="bubblelink code" onclick="return showCourse(this, '6.C51');">6.C51</a>. </p> <p class="courseblockinstructors seemore"><span><i>J. Davis</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.S930 Special Subject in Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Fall, Spring, Summer)</span><br/><span class="courseblockhours">Units arranged [P/D/F]</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Covers material in various fields of biology not offered by the regular subjects of instruction. </p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.S931 Special Subject in Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Fall, Spring, Summer)</span><br/><span class="courseblockhours">Units arranged [P/D/F]</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Covers material in various fields of biology not offered by the regular subjects of instruction. </p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.S932 Special Subject in Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Fall, IAP, Spring)<br/> Not offered regularly; consult department</span><br/><span class="courseblockhours">Units arranged [P/D/F]</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Covers material in various fields of biology not offered by the regular subjects of instruction. </p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.S939 Special Subject in Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Fall, IAP, Spring)</span><br/><span class="courseblockhours">Units arranged</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Covers material in various fields of biology not offered by the regular subjects of instruction. </p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>7.THG Graduate Biology Thesis</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Fall, IAP, Spring, Summer)</span><br/><span class="courseblockhours">Units arranged</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Program of research leading to the writing of a Ph.D. thesis; to be arranged by the student and an appropriate MIT faculty member. </p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div></div> </div> </div>  </div> </div>  <div id="footer" role="contentinfo"> <div class="wrap"> <div id="footer-links"> <a href="http://mitadmissions.org/apply" target="_blank">Admissions</a><a href="http://sfs.mit.edu/" target="_blank">Financial Aid</a><a href="http://web.mit.edu/registrar/" target="_blank">Registrar</a><a href="http://web.mit.edu/iap/" target="_blank">IAP</a><a href="/summer/">Summer</a><a href="http://professional.mit.edu" target="_blank">Professional Education</a><a href="https://www.edx.org/school/mitx" class="mitx" target="_blank">MITx</a><a href="https://outreach.mit.edu/" target="_blank">K-12</a><a href="http://whereis.mit.edu/" target="_blank">Campus Map</a><br/><a href="https://officesdirectory.mit.edu/" target="_blank">Directories</a><a href="/about-bulletin/">About the Bulletin</a><a href="/nondiscrimination-policy/">Nondiscrimination Policy</a><a href="/changelog/">Changes</a><a href="/help/">Help</a><a href="https://accessibility.mit.edu/" target="_blank">Accessibility</a> </div> <div id="footer-branding" class="clearfix"> <div class="foot-col" id="right"> <div id="footer-mit-logo"><img src="/images/mit-logo-footer.svg" alt="MIT" width="185px" /></div> </div> <div class="foot-col" id="left"> <div id="footer-bulletin"><img src="/images/mit-bulletin-logo-footer-24-25.png" alt="MIT Academic Bulletin" /></div> <div id="footer-contact">77 Massachusetts Avenue<br/>Cambridge, MA 02139-4307</div> </div> </div> </div> <a href="#header" id="totop"><span class="sr-only">Back to top</span></a> </div>  <div id="print-dialog" class="screen noscript" role="dialog"> <div class="print-header"> Print Options </div> <div class="print-body"> <div class="print-option"> <div class="option-head"> <a href="#" onclick="hidePrintDialog();window.print();return false">Send Page to Printer</a> </div> <p> <em>Print this page.</em> </p> </div> <div class="print-option"><div class="option-head"><a href="7.pdf" target="_blank">Download PDF of this Page</a></div><p><em>The PDF includes all information on this page and its related tabs. 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