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<!doctype html> <html lang="ru"> <head> <title>Duchenne Muscular Dystrophy: A Review on Systemic Paradigm A | 106246</title> <meta name="keywords" content="Srabaita Roy, Ranjit Shaw, Audditiya Bandopadhyay, Sukanya Samaddar, Sukanya Samanta, Ritwija Maity, Puja Chatterjee, Ankita Das, Suchismita Bhaumik, Gyaneshwer Chaubey, "/> <meta name="description" content="Duchenne Muscular Dystrophy (DMD) is a severe congenital disorder caused by DMD gene mutations, which results in muscular degeneration and movement diff..106246"/> <meta name="citation_publisher" content="袥芯薪谐写芯屑懈蟹写邪褌械谢褜褋泻邪褟小袥" /> <meta name="citation_journal_title" content="袞褍褉薪邪谢谐械薪械褌懈褔械褋泻懈褏褋懈薪写褉芯屑芯胁懈谐械薪薪芯泄褌械褉邪锌懈懈"> <meta name="citation_title" content="Duchenne Muscular Dystrophy: A Review on Systemic Paradigm Approaching Diagnosis to Therapy"> <meta name="citation_author" content="Srabaita Roy" /> <meta name="citation_author" content="Ranjit Shaw" /> <meta name="citation_author" content="Audditiya B" /> <meta name="citation_author" content="opadhyay" /> <meta name="citation_author" content="Sukanya Samaddar" /> <meta name="citation_author" content="Sukanya Samanta" /> <meta name="citation_author" content="Ritwija Maity" /> <meta name="citation_author" content="Puja Chatterjee" /> <meta name="citation_author" content="Ankita Das" /> <meta name="citation_author" content="Suchismita Bhaumik" /> <meta name="citation_author" content="Gyaneshwer Chaubey" /> <meta name="citation_year" content=""> <meta name="citation_volume" content="15"> <meta name="citation_issue" content="1"> <meta name="citation_abstract" content="Duchenne Muscular Dystrophy (DMD) is a severe congenital disorder caused by DMD gene mutations, which results in muscular degeneration and movement difficulties, eventually leading to death. Whereas its less severe form, Becker Muscular Dystrophy (BMD), also caused by the DMD gene mutations, shows slower patterns of progression with much later onset. This review discusses the various mutations resulting in DMD, its genetic basis, the diagnostic tools for performing a genetic diagnosis of having DMD and also advocates the necessity of having genetic therapies and employing nutraceuticals for therapy in the context of this disease. Furthermore, we have also highlighted several treatment options, such as antibacterial drugs, AON-mediated exon skipping therapy, Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR-Cas9) gene-editing technology, nutraceuticals and other significant approaches that have resulted in more promising and durable cures. However, these methods are still under clinical trials. As a whole, our review presents a holistic view of this muscle malady."> <meta name="citation_abstract_html_url" content="https://russian.longdom.org/abstract/duchenne-muscular-dystrophy-a-review-on-systemic-paradigm-approaching-diagnosis-to-therapy-106246.html"> <meta name="format-detection" content="telephone=no"> <meta http-equiv="Content-Language" content="ru"> <meta name="google-site-verification" content="NomPTP94YozsgvD3NEFpNqUfY88e0TU0L64zNzZTpd0" /> <meta itemprop="name" content="longdom" /> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <meta name="ROBOTS" content="INDEX,FOLLOW"> <meta name="googlebot" content="INDEX,FOLLOW"> <meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"> <link rel="canonical" href="https://russian.longdom.org/abstract/duchenne-muscular-dystrophy-a-review-on-systemic-paradigm-approaching-diagnosis-to-therapy-106246.html"> <link rel="alternate" 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title="袧邪卸屑懈褌械蟹写械褋褜">袠薪写械泻褋懈褉芯胁邪薪懈械懈邪褉褏懈胁懈褉芯胁邪薪懈械</a> <a class="nav-item nav-link" href="https://russian.longdom.org/genetic-syndromes-gene-therapy/archive.html" title="袧邪卸屑懈褌械蟹写械褋褜">袠薪写械泻褋懈褉芯胁邪薪懈械懈邪褉褏懈胁懈褉芯胁邪薪懈械</a> <a class="nav-item nav-link" href="https://www.longdom.org/submissions/genetic-syndromes-gene-therapy.html" title="袧邪卸屑懈褌械蟹写械褋褜">袨褌锌褉邪胁懈褌褜褉褍泻芯锌懈褋褜</a> </nav> </div> </div>     <div class="card shadow-sm sidebar mb-3"> <h6 class="card-header">袞褍褉薪邪谢褘芯褌泻褉褘褌芯谐芯写芯褋褌褍锌邪</h6> <div class="card-body p-0 scroll_mang"> <nav class="nav flex-column font-size-3 icon-list icon-list-angle-right a-py-1"> <a class="nav-item nav-link" href="https://russian.longdom.org/bioinformatics-and-systems-biology-journals.html" title="袧邪卸屑懈褌械蟹写械褋褜">袘懈芯懈薪褎芯褉屑邪褌懈泻邪懈褋懈褋褌械屑薪邪褟斜懈芯谢芯谐懈褟</a><br> <a class="nav-item nav-link" href="https://russian.longdom.org/biochemistry-journals.html" title="袧邪卸屑懈褌械蟹写械褋褜">袘懈芯褏懈屑懈褟</a><br> <a class="nav-item nav-link" 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title="袧邪卸屑懈褌械蟹写械褋褜">袧械胁褉芯谢芯谐懈褟懈锌褋懈褏芯谢芯谐懈褟</a><br> <a class="nav-item nav-link" href="https://russian.longdom.org/general-science-journals.html" title="袧邪卸屑懈褌械蟹写械褋褜">袨斜褖邪褟薪邪褍泻邪</a><br> <a class="nav-item nav-link" href="https://russian.longdom.org/agri-and-aquaculture-journals.html" title="袧邪卸屑懈褌械蟹写械褋褜">小械谢褜褋泻芯械褏芯蟹褟泄褋褌胁芯懈邪泻胁邪泻褍谢褜褌褍褉邪</a><br> <a class="nav-item nav-link" href="https://russian.longdom.org/nursing-and-health-care-journals.html" title="袧邪卸屑懈褌械蟹写械褋褜">小械褋褌褉懈薪褋泻芯械写械谢芯懈蟹写褉邪胁芯芯褏褉邪薪械薪懈械</a><br> <a class="nav-item nav-link" href="https://russian.longdom.org/business-and-management-journals.html" title="袧邪卸屑懈褌械蟹写械褋褜">校锌褉邪胁谢械薪懈械斜懈蟹薪械褋芯屑</a><br> <a class="nav-item nav-link" href="https://russian.longdom.org/pharmaceutical-sciences-journals.html" title="袧邪卸屑懈褌械蟹写械褋褜">肖邪褉屑邪褑械胁褌懈褔械褋泻懈械薪邪褍泻懈</a><br> <a class="nav-item nav-link" href="https://russian.longdom.org/chemistry-journals.html" title="袧邪卸屑懈褌械蟹写械褋褜">啸懈屑懈褟</a><br> </nav> </div> </div>  </aside> <div class="col-12 col-sm-9"> <h2 class="heading-1">袗斜褋褌褉邪泻褌薪褘泄</h2> <h3 class="">Duchenne Muscular Dystrophy: A Review on Systemic Paradigm Approaching Diagnosis to Therapy</h3> <p> <i class="fas fa-user"></i> Srabaita Roy, Ranjit Shaw, Audditiya Bandopadhyay, Sukanya Samaddar, Sukanya Samanta, Ritwija Maity, Puja Chatterjee, Ankita Das, Suchismita Bhaumik, Gyaneshwer Chaubey </p> <p>Duchenne Muscular Dystrophy (DMD) is a severe congenital disorder caused by DMD gene mutations, which results in muscular degeneration and movement difficulties, eventually leading to death. Whereas its less severe form, Becker Muscular Dystrophy (BMD), also caused by the DMD gene mutations, shows slower patterns of progression with much later onset. This review discusses the various mutations resulting in DMD, its genetic basis, the diagnostic tools for performing a genetic diagnosis of having DMD and also advocates the necessity of having genetic therapies and employing nutraceuticals for therapy in the context of this disease. Furthermore, we have also highlighted several treatment options, such as antibacterial drugs, AON-mediated exon skipping therapy, Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR-Cas9) gene-editing technology, nutraceuticals and other significant approaches that have resulted in more promising and durable cures. However, these methods are still under clinical trials. As a whole, our review presents a holistic view of this muscle malady.</p> <div class="alert alert-info text-left"><b>袨褌泻邪蟹芯褌芯褌胁械褌褋褌胁械薪薪芯褋褌懈:</b> 协褌芯褌褌械蟹懈褋斜褘谢锌械褉械胁械写械薪褋懈褋锌芯谢褜蟹芯胁邪薪懈械屑懈薪褋褌褉褍屑械薪褌芯胁懈褋泻褍褋褋褌胁械薪薪芯谐芯懈薪褌械谢谢械泻褌邪懈械褖械薪械锌褉芯褕械谢褉械褑械薪蟹懈褉芯胁邪薪懈械懈谢懈锌褉芯胁械褉泻褍.</div> <div class="nav social-icons"> <a class="nav-link w-auto">袩芯写械谢懈褌械褋褜褝褌芯泄褋褌邪褌褜械泄</a> <a title="袧邪卸屑懈褌械蟹写械褋褜" target="_blank" href="https://www.facebook.com/sharer.php?u=https://russian.longdom.org/abstract/duchenne-muscular-dystrophy-a-review-on-systemic-paradigm-approaching-diagnosis-to-therapy-106246.html" rel="noopener"><i class="fab fa-facebook-f"></i></a> <a class="nav-link" title="袧邪卸屑懈褌械蟹写械褋褜" target="_blank" href="https://twitter.com/share?url=https://russian.longdom.org/abstract/duchenne-muscular-dystrophy-a-review-on-systemic-paradigm-approaching-diagnosis-to-therapy-106246.html" rel="noopener"><i class="fab fa-twitter"></i></a> <a class="nav-link" title="袧邪卸屑懈褌械蟹写械褋褜" target="_blank" href="https://www.linkedin.com/shareArticle?mini=true&url=https://russian.longdom.org/abstract/duchenne-muscular-dystrophy-a-review-on-systemic-paradigm-approaching-diagnosis-to-therapy-106246.html" rel="noopener"><i class="fab fa-linkedin-in"></i></a> <a class="nav-link" title="袧邪卸屑懈褌械蟹写械褋褜" target="_blank" href="https://plus.google.com/share?url=https://russian.longdom.org/abstract/duchenne-muscular-dystrophy-a-review-on-systemic-paradigm-approaching-diagnosis-to-therapy-106246.html" rel="noopener"><i class="fab fa-google-plus-g"></i></a> </div> </div> </div> </div> </section> <footer class="bg-blue-grey-900 py-3"> <div class="container"> <div class="row"> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">小褋褘谢泻懈薪邪泻芯薪褌械薪褌</h4> <ul class="list-unstyled footer-links font-size-3"> <li><a class="" href="https://russian.longdom.org/privacy-policy.html" title="袧邪卸屑懈褌械蟹写械褋褜">袩芯谢懈褌懈泻邪泻芯薪褎懈写械薪褑懈邪谢褜薪芯褋褌懈</a></li> <li><a class="" href="https://russian.longdom.org/terms-conditions.html" title="袧邪卸屑懈褌械蟹写械褋褜">校褋谢芯胁懈褟懈褋锌芯谢褜蟹芯胁邪薪懈褟</a></li> <li><a class="" href="https://russian.longdom.org/authors-reviewers-editors.html" title="袧邪卸屑懈褌械蟹写械褋褜">袗胁褌芯褉褘, 褉械褑械薪蟹械薪褌褘懈褉械写邪泻褌芯褉褘</a></li> </ul> </div> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">小胁褟蟹邪褌褜褋褟褋袥芯薪谐写芯屑</h4> <p><strong>Longdom Group SA</strong><br /> 袗胁械薪褞袪芯写卸械褉邪袙邪薪写械薪写褉懈褕械,<br /> 18, 1150 袘褉褞褋褋械谢褜, 袘械谢褜谐懈褟<br /> 孝械谢械褎芯薪: +442038085340<br /> <strong>协谢械泻褌褉芯薪薪邪褟锌芯褔褌邪:</strong> <a class="white" href="mailto:info@longdom.org" title="袧邪卸屑懈褌械蟹写械褋褜">info@longdom.org</a></p> </div> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">小芯械写懈薪褟褌褜</h4> <nav class="nav nav-pills social-icons-footer flex-column a-pl-0"> <a href="https://www.facebook.com/longdompublisher" title="袧邪卸屑懈褌械蟹写械褋褜" target="_blank" class="nav-link bg-facebook-hover"><i class="fab fa-facebook-f bg-facebook"></i></a> <a href="https://www.linkedin.com/company/longdom-publishing-sl/" title="袧邪卸屑懈褌械蟹写械褋褜" target="_blank" class="nav-link bg-linkedin-hover"><i class="fab fa-linkedin-in bg-linkedin"></i></a> <a href="https://twitter.com/LongdomP" title="袧邪卸屑懈褌械蟹写械褋褜" target="_blank" class="nav-link bg-twitter-hover"><i class="fab fa-twitter bg-twitter"></i></a> <a href="https://www.instagram.com/longdom_publisher/" title="袧邪卸屑懈褌械蟹写械褋褜" target="_blank" class="nav-link bg-instagram-hover"><i class="fab fa-instagram bg-instagram"></i></a> </nav> </div> </div> <div class="row text-center"> <div class="col"> <p>袗胁褌芯褉褋泻懈械锌褉邪胁邪 © 2024 <a href="https://russian.longdom.org/" title="袧邪卸屑懈褌械蟹写械褋褜" class="white">袠蟹写邪褌械谢褜褋褌胁芯 Longdom SL</a>.</p> </div> </div> </div> </footer>  <a href="#0" class="cd-top js-cd-top">Top</a>   <script src="https://code.jquery.com/jquery-3.3.1.min.js"></script> <script src="https://cdnjs.cloudflare.com/ajax/libs/popper.js/1.14.7/umd/popper.min.js"></script> <script src="https://stackpath.bootstrapcdn.com/bootstrap/4.3.1/js/bootstrap.min.js"></script>  <script> jQuery(function($) { $(window).scroll(function fix_element() { $('#target').css( $(window).scrollTop() > 100 ? 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