Canadian Journal of Neurological Sciences: Volume 47 - Issue 6

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if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="2D0C5618650118056AAFE93AA41471CD" data-container="representation" aria-label="Export citation for Embryology of Spinal Dysraphism and its Relationship to Surgical Treatment">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS031716712000075X')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for Embryology of Spinal Dysraphism and its Relationship to Surgical Treatment" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/562320B78FEF746DAD9BB6ECBEE0A5D9","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"2D0C5618650118056AAFE93AA41471CD"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS031716712000075X" class="content"> <div class="abstract" data-abstract-type="normal"><p>Spinal dysraphism is an umbrella term that encompasses a number of congenital malformations that affect the central nervous system. The etiology of these conditions can be traced back to a specific defect in embryological development, with the more disabling malformations occurring at an earlier gestational age. A thorough understanding of the relevant neuroembryology is imperative for clinicians to select the correct treatment and prevent complications associated with spinal dysraphism. This paper will review the neuroembryology associated with the various forms of spinal dysraphism and provide a clinical-pathological correlation for these congenital malformations.</p></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.75" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.75" data-link-target="_blank"></div> </div> </div> </div> <div class="representation overview search" data-prod-id="9BE86E472374C288AAE6A2E7421526E4" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/562320B78FEF746DAD9BB6ECBEE0A5D9","productId":"9BE86E472374C288AAE6A2E7421526E4","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="9BE86E472374C288AAE6A2E7421526E4" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="553851" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/focused-update-on-tardive-dyskinesia/9BE86E472374C288AAE6A2E7421526E4"> A Focused Update on Tardive Dyskinesia </a></h3></li> <li></li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Pierre J. Blanchet&eventCode=SE-AU" class="more-by-this-author ">Pierre J. Blanchet</a> </li> <li> <dl> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 06 July 2020</span><span class="pages">, pp. 747-755</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-9BE86E472374C288AAE6A2E7421526E4" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/9BE86E472374C288AAE6A2E7421526E4/S0317167120001316a.pdf/focused_update_on_tardive_dyskinesia.pdf" data-pdf-content-id="9BE86E472374C288AAE6A2E7421526E4" target="_blank" aria-label="Download PDF for A Focused Update on Tardive Dyskinesia [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/9BE86E472374C288AAE6A2E7421526E4/core-reader" target="_blank" aria-label="View HTML full text for A Focused Update on Tardive Dyskinesia [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/562320B78FEF746DAD9BB6ECBEE0A5D9","productId":"9BE86E472374C288AAE6A2E7421526E4","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="9BE86E472374C288AAE6A2E7421526E4" data-container="representation" aria-label="Export citation for A Focused Update on Tardive Dyskinesia">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS0317167120001316')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for A Focused Update on Tardive Dyskinesia" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/562320B78FEF746DAD9BB6ECBEE0A5D9","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"9BE86E472374C288AAE6A2E7421526E4"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS0317167120001316" class="content"> <div class="abstract" data-abstract-type="normal"><p>Tardive dyskinesia (TD) is a delayed and potentially irreversible motor complication following chronic exposure to centrally acting dopamine receptor antagonists, mainly of the class of antipsychotics drugs. New generations of antipsychotic drugs reduced its mean prevalence to 20%, but it continues to mar the drug experience and social integration in a significant fraction of patients. The underlying molecular cascade remains elusive, explaining in part why TD management is so often difficult. Protocol variations between experimental laboratories and inter-species differences in the biological response to antipsychotic drugs have added layers of complexity. The traditional dopamine D<span class='sub'>2</span> receptor supersensitivity hypothesis was revisited in an experimental nonhuman primate model. Findings in the striatum revealed a strong upregulation of D<span class='sub'>3</span>, not D<span class='sub'>2</span>, receptors specific to dyskinetic animals, and indirect evidence suggestive of a link between overactivation of glycogen synthase kinase-3β signaling and TD. New effective vesicular monoamine transporter type 2 inhibitors alleviating TD have been approved in the USA. They were integrated to an emerging stepwise treatment algorithm for troublesome TD, which also includes consideration for changes in the current antipsychotic drug regimen and recognition of potentially aggravating factors such as anticholinergic co-medications. These advances may benefit TD.</p></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.131" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.131" data-link-target="_blank"></div> </div> </div> </div> <h4 class="journal-article-listing-type heading_12 margin-bottom">Original Article</h4> <div class="representation overview search" data-prod-id="A14648B2FF0EA5BF30F87C6EE58F99B2" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/562320B78FEF746DAD9BB6ECBEE0A5D9","productId":"A14648B2FF0EA5BF30F87C6EE58F99B2","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="A14648B2FF0EA5BF30F87C6EE58F99B2" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="200888" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/methods-for-improving-screening-for-vascular-cognitive-impairment-using-the-montreal-cognitive-assessment/A14648B2FF0EA5BF30F87C6EE58F99B2"> Methods for Improving Screening for Vascular Cognitive Impairment Using the Montreal Cognitive Assessment </a></h3></li> <li> Part of: <ul class="partOfCollection"> <li><a href="/core/product/identifier/DFF7E9D6-32B8-43DD-A093-075255FB2ABF/type/BESPOKE_COLLECTION" class="">CJNS Editor’s Choice Articles</a></li> </ul> </li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Khush-Bakht Zaidi&eventCode=SE-AU" class="more-by-this-author ">Khush-Bakht Zaidi</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Jill B. Rich&eventCode=SE-AU" class="more-by-this-author ">Jill B. Rich</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Kelly M. Sunderland&eventCode=SE-AU" class="more-by-this-author ">Kelly M. Sunderland</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Malcolm A. Binns&eventCode=SE-AU" class="more-by-this-author ">Malcolm A. Binns</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Linda Truong&eventCode=SE-AU" class="more-by-this-author ">Linda Truong</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Paula M. McLaughlin&eventCode=SE-AU" class="more-by-this-author ">Paula M. 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Sahlas</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Dariush Dowlatshahi&eventCode=SE-AU" class="more-by-this-author ">Dariush Dowlatshahi</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Ayman Hassan&eventCode=SE-AU" class="more-by-this-author ">Ayman Hassan</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Jennifer Mandzia&eventCode=SE-AU" class="more-by-this-author ">Jennifer Mandzia</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=The ONDRI Investigators&eventCode=SE-AU" class="more-by-this-author ">The ONDRI Investigators</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Angela K. Troyer&eventCode=SE-AU" class="more-by-this-author ">Angela K. Troyer</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Richard H. Swartz&eventCode=SE-AU" class="more-by-this-author ">Richard H. Swartz</a> </li> <li> <dl> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 11 June 2020</span><span class="pages">, pp. 756-763</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-A14648B2FF0EA5BF30F87C6EE58F99B2" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/A14648B2FF0EA5BF30F87C6EE58F99B2/S0317167120001213a.pdf/methods_for_improving_screening_for_vascular_cognitive_impairment_using_the_montreal_cognitive_assessment.pdf" data-pdf-content-id="A14648B2FF0EA5BF30F87C6EE58F99B2" target="_blank" aria-label="Download PDF for Methods for Improving Screening for Vascular Cognitive Impairment Using the Montreal Cognitive Assessment [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/A14648B2FF0EA5BF30F87C6EE58F99B2/core-reader" target="_blank" aria-label="View HTML full text for Methods for Improving Screening for Vascular Cognitive Impairment Using the Montreal Cognitive Assessment [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/562320B78FEF746DAD9BB6ECBEE0A5D9","productId":"A14648B2FF0EA5BF30F87C6EE58F99B2","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="A14648B2FF0EA5BF30F87C6EE58F99B2" data-container="representation" aria-label="Export citation for Methods for Improving Screening for Vascular Cognitive Impairment Using the Montreal Cognitive Assessment">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS0317167120001213')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for Methods for Improving Screening for Vascular Cognitive Impairment Using the Montreal Cognitive Assessment" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/562320B78FEF746DAD9BB6ECBEE0A5D9","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"A14648B2FF0EA5BF30F87C6EE58F99B2"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS0317167120001213" class="content"> <div class="abstract" data-abstract-type="normal"><div class='sec'><span class="bold">Background:</span><p>Vascular cognitive impairment (VCI) post-stroke is frequent but may go undetected, which highlights the need to better screen cognitive functioning following a stroke.</p></div><div class='sec'><span class="bold">Aim:</span><p>We examined the clinical utility of the Montreal Cognitive Assessment (MoCA) in detecting cognitive impairment against a gold-standard neuropsychological battery.</p></div><div class='sec'><span class="bold">Methods:</span><p>We assessed cognitive status with a comprehensive battery of neuropsychological tests in 161 individuals who were at least 3-months post-stroke. We used receiver operating characteristic (ROC) curves to identify two cut points for the MoCA to maximize sensitivity and specificity at a minimum 90% threshold. We examined the utility of the Symbol Digit Modalities Test, a processing speed measure, to determine whether this additional metric would improve classification relative to the MoCA total score alone.</p></div><div class='sec'><span class="bold">Results:</span><p>Using two cut points, 27% of participants scored ≤ 23 and were classified as high probability of cognitive impairment (sensitivity 92%), and 24% of participants scored ≥ 28 and were classified as low probability of cognitive impairment (specificity 91%). The remaining 48% of participants scored from 24 to 27 and were classified as indeterminate probability of cognitive impairment. The addition of a processing speed measure improved classification for the indeterminate group by correctly identifying 65% of these individuals, for an overall classification accuracy of 79%.</p></div><div class='sec'><span class="bold">Conclusions:</span><p>The utility of the MoCA in detecting cognitive impairment post-stroke is improved when using a three-category approach. The addition of a processing speed measure provides a practical and efficient method to increase confidence in the determined outcome while minimally extending the screening routine for VCI.</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.121" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.121" data-link-target="_blank"></div> </div> </div> </div> <div class="representation overview search" data-prod-id="10D88E13C33295E36609070CA779408F" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/562320B78FEF746DAD9BB6ECBEE0A5D9","productId":"10D88E13C33295E36609070CA779408F","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="10D88E13C33295E36609070CA779408F" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="310637" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/call-911-lower-ambulance-utilization-among-young-adults-especially-women-with-stroke/10D88E13C33295E36609070CA779408F"> Call 911: Lower Ambulance Utilization Among Young Adults, Especially Women, with Stroke </a></h3></li> <li></li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Arunima Kapoor&eventCode=SE-AU" class="more-by-this-author ">Arunima Kapoor</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=M. Patrice Lindsay&eventCode=SE-AU" class="more-by-this-author ">M. Patrice Lindsay</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Amy Y.X. Yu&eventCode=SE-AU" class="more-by-this-author ">Amy Y.X. Yu</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Cristina Goia&eventCode=SE-AU" class="more-by-this-author ">Cristina Goia</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Sheldon Cheskes&eventCode=SE-AU" class="more-by-this-author ">Sheldon Cheskes</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=P. Richard Verbeek&eventCode=SE-AU" class="more-by-this-author ">P. Richard Verbeek</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Richard H. Swartz&eventCode=SE-AU" class="more-by-this-author ">Richard H. Swartz</a> </li> <li> <dl> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 08 June 2020</span><span class="pages">, pp. 764-769</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-10D88E13C33295E36609070CA779408F" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/10D88E13C33295E36609070CA779408F/S0317167120001195a.pdf/call_911_lower_ambulance_utilization_among_young_adults_especially_women_with_stroke.pdf" data-pdf-content-id="10D88E13C33295E36609070CA779408F" target="_blank" aria-label="Download PDF for Call 911: Lower Ambulance Utilization Among Young Adults, Especially Women, with Stroke [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/10D88E13C33295E36609070CA779408F/core-reader" target="_blank" aria-label="View HTML full text for Call 911: Lower Ambulance Utilization Among Young Adults, Especially Women, with Stroke [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/562320B78FEF746DAD9BB6ECBEE0A5D9","productId":"10D88E13C33295E36609070CA779408F","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="10D88E13C33295E36609070CA779408F" data-container="representation" aria-label="Export citation for Call 911: Lower Ambulance Utilization Among Young Adults, Especially Women, with Stroke">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS0317167120001195')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for Call 911: Lower Ambulance Utilization Among Young Adults, Especially Women, with Stroke" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/562320B78FEF746DAD9BB6ECBEE0A5D9","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"10D88E13C33295E36609070CA779408F"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS0317167120001195" class="content"> <div class="abstract" data-abstract-type="normal"><div class='sec'><span class="bold">Background:</span><p>Delayed presentation to the emergency department influences acute stroke care and can result in worse outcomes. Despite public health messaging, many young adults consider stroke as a disease of older people. We determined the differences in ambulance utilization and delays to hospital presentation between women and men as well as younger (18–44 years) versus older (≥45 years) patients with stroke.</p></div><div class='sec'><span class="bold">Methods:</span><p>We conducted a population-based retrospective study using national administrative health data from the Canadian Institute of Health Information databases and examined data between 2003 and 2016 to compare ambulance utilization and time to hospital presentation across sex and age.</p></div><div class='sec'><span class="bold">Results:</span><p>Young adults account for 3.9% of 463,310 stroke/transient ischemic attack/hemorrhage admissions. They have a higher proportion of hemorrhage (37% vs. 15%) and fewer ischemic events (50% vs. 68%) compared with older patients. Younger patients are less likely to arrive by ambulance (62% vs. 66%, p < 0.001), with younger women least likely to use ambulance services (61%) and older women most likely (68%). Median stroke onset to hospital arrival times were 7 h for older patients and younger men, but 9 h in younger women. There has been no improvement among young women in ambulance utilization since 2003, whereas ambulance use increased in all other groups.</p></div><div class='sec'><span class="bold">Conclusions:</span><p>Younger adults, especially younger women, are less likely to use ambulance services, take longer to get to hospital, and have not improved in utilization of emergency services for stroke over 13 years. Targeted public health messaging is required to ensure younger adults seek emergency stroke care.</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.119" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.119" data-link-target="_blank"></div> </div> </div> </div> <div class="representation overview search" data-prod-id="ED66562E8DC09F5E9DE398470B3188D3" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/562320B78FEF746DAD9BB6ECBEE0A5D9","productId":"ED66562E8DC09F5E9DE398470B3188D3","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="ED66562E8DC09F5E9DE398470B3188D3" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="238608" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/delayed-thrombectomy-center-arrival-is-associated-with-decreased-treatment-probability/ED66562E8DC09F5E9DE398470B3188D3"> Delayed Thrombectomy Center Arrival is Associated with Decreased Treatment Probability </a></h3></li> <li></li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Meah M. Gao&eventCode=SE-AU" class="more-by-this-author ">Meah M. Gao</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Jeffrey Z. Wang&eventCode=SE-AU" class="more-by-this-author ">Jeffrey Z. Wang</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Jane Liao&eventCode=SE-AU" class="more-by-this-author ">Jane Liao</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Stephanie D. Reiter&eventCode=SE-AU" class="more-by-this-author ">Stephanie D. Reiter</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Manav V. Vyas&eventCode=SE-AU" class="more-by-this-author ">Manav V. Vyas</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Elizabeth Linkewich&eventCode=SE-AU" class="more-by-this-author ">Elizabeth Linkewich</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Richard H. Swartz&eventCode=SE-AU" class="more-by-this-author ">Richard H. Swartz</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Leodante da Costa&eventCode=SE-AU" class="more-by-this-author ">Leodante da Costa</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Charles D. Kassardjian&eventCode=SE-AU" class="more-by-this-author ">Charles D. Kassardjian</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Amy Y. X. Yu&eventCode=SE-AU" class="more-by-this-author ">Amy Y. X. Yu</a> </li> <li> <dl> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 18 May 2020</span><span class="pages">, pp. 770-774</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-ED66562E8DC09F5E9DE398470B3188D3" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/ED66562E8DC09F5E9DE398470B3188D3/S0317167120000955a.pdf/delayed_thrombectomy_center_arrival_is_associated_with_decreased_treatment_probability.pdf" data-pdf-content-id="ED66562E8DC09F5E9DE398470B3188D3" target="_blank" aria-label="Download PDF for Delayed Thrombectomy Center Arrival is Associated with Decreased Treatment Probability [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/ED66562E8DC09F5E9DE398470B3188D3/core-reader" target="_blank" aria-label="View HTML full text for Delayed Thrombectomy Center Arrival is Associated with Decreased Treatment Probability [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/562320B78FEF746DAD9BB6ECBEE0A5D9","productId":"ED66562E8DC09F5E9DE398470B3188D3","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="ED66562E8DC09F5E9DE398470B3188D3" data-container="representation" aria-label="Export citation for Delayed Thrombectomy Center Arrival is Associated with Decreased Treatment Probability">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS0317167120000955')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for Delayed Thrombectomy Center Arrival is Associated with Decreased Treatment Probability" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/562320B78FEF746DAD9BB6ECBEE0A5D9","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"ED66562E8DC09F5E9DE398470B3188D3"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS0317167120000955" class="content"> <div class="abstract" data-abstract-type="normal"><div class='sec'><span class="bold">Background:</span><p>Endovascular thrombectomy (EVT) is effective in reducing disability in selected patients with stroke and large vessel occlusion (LVO), but access to this treatment is suboptimal.</p></div><div class='sec'><span class="bold">Aim:</span><p>We examined the proportion of patients with LVO who did not receive EVT, the reasons for non-treatment, and the association between time from onset and probability of treatment.</p></div><div class='sec'><span class="bold">Methods:</span><p>We conducted a retrospective cohort study of consecutive patients with acute stroke and LVO presenting between January 2017 and June 2018. We used multivariable log-binomial models to determine the association between time and probability of treatment with and without adjustment for age, sex, dementia, active cancer, baseline disability, stroke severity, and evidence of ischemia on computerized tomography.</p></div><div class='sec'><span class="bold">Results:</span><p>We identified 256 patients (51% female, median age 74 [interquartile range, IQR 63.5, 82.5]), of whom 59% did not receive EVT. The main reasons for not treating with EVT were related to occlusion characteristics or infarct size. The median time from onset to EVT center arrival was longer among non-treated patients (218 minutes [142, 302]) than those who were treated (180 minutes [104, 265], p = 0.03). Among patients presenting within 6 hours of onset, the relative risk (RR) of receiving EVT decreased by 3% with every 10-minute delay in arrival to EVT center (adjusted RR 0.97 CI<span class='sub'>95</span> [0.95, 0.99]). This association was not found in the overall cohort.</p></div><div class='sec'><span class="bold">Conclusions:</span><p>The proportion of patients with acute stroke and confirmed LVO who do not undergo EVT is substantial. Minimizing delays in arrival to EVT center may optimize the delivery of this treatment.</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.95" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.95" data-link-target="_blank"></div> </div> </div> </div> <div class="representation overview search" data-prod-id="75FA7377FC2B2936604AD626EADE36EA" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/562320B78FEF746DAD9BB6ECBEE0A5D9","productId":"75FA7377FC2B2936604AD626EADE36EA","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="75FA7377FC2B2936604AD626EADE36EA" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="796974" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/determining-corticospinal-tract-injury-from-stroke-using-computed-tomography/75FA7377FC2B2936604AD626EADE36EA"> Determining Corticospinal Tract Injury from Stroke Using Computed Tomography </a></h3></li> <li></li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Timothy K. Lam&eventCode=SE-AU" class="more-by-this-author ">Timothy K. Lam</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Daniel K. Cheung&eventCode=SE-AU" class="more-by-this-author ">Daniel K. Cheung</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Seth A. Climans&eventCode=SE-AU" class="more-by-this-author ">Seth A. Climans</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Sandra E. Black&eventCode=SE-AU" class="more-by-this-author ">Sandra E. Black</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Fuqiang Gao&eventCode=SE-AU" class="more-by-this-author ">Fuqiang Gao</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Gregory M. Szilagyi&eventCode=SE-AU" class="more-by-this-author ">Gregory M. Szilagyi</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=George Mochizuki&eventCode=SE-AU" class="more-by-this-author ">George Mochizuki</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Joyce L. Chen&eventCode=SE-AU" class="more-by-this-author ">Joyce L. Chen</a> </li> <li> <dl> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 04 June 2020</span><span class="pages">, pp. 775-784</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-75FA7377FC2B2936604AD626EADE36EA" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/75FA7377FC2B2936604AD626EADE36EA/S0317167120001122a.pdf/determining_corticospinal_tract_injury_from_stroke_using_computed_tomography.pdf" data-pdf-content-id="75FA7377FC2B2936604AD626EADE36EA" target="_blank" aria-label="Download PDF for Determining Corticospinal Tract Injury from Stroke Using Computed Tomography [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/75FA7377FC2B2936604AD626EADE36EA/core-reader" target="_blank" aria-label="View HTML full text for Determining Corticospinal Tract Injury from Stroke Using Computed Tomography [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/562320B78FEF746DAD9BB6ECBEE0A5D9","productId":"75FA7377FC2B2936604AD626EADE36EA","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="75FA7377FC2B2936604AD626EADE36EA" data-container="representation" aria-label="Export citation for Determining Corticospinal Tract Injury from Stroke Using Computed Tomography">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS0317167120001122')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for Determining Corticospinal Tract Injury from Stroke Using Computed Tomography" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/562320B78FEF746DAD9BB6ECBEE0A5D9","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"75FA7377FC2B2936604AD626EADE36EA"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS0317167120001122" class="content"> <div class="abstract" data-abstract-type="normal"><div class='sec'><span class="bold">Introduction:</span><p>Damage to the corticospinal tract (CST) from stroke leads to motor deficits. The damage can be quantified as the amount of overlap between the stroke lesion and CST (CST Injury). Previous literature has shown that the degree of motor deficits post-stroke is related to the amount of CST Injury. These studies delineate the stroke lesion from structural T1-weighted magnetic resonance imaging (MRI) scans, often acquired for research. In Canada, computed tomography (CT) is the most common imaging modality used in routine acute stroke care. In this proof-of-principle study, we determine whether CST Injury, using lesions delineated from CT scans, significantly explains the variability in motor impairment in individuals with stroke.</p></div><div class='sec'><span class="bold">Methods:</span><p>Thirty-seven participants with stroke were included in this study. These individuals had a CT scan within the acute stage (7 days) of their stroke and underwent motor assessments. Brain images from CT scans were registered to MRI space. We performed a stepwise regression analysis to determine the contribution of CST injury and demographic variables in explaining motor impairment variability.</p></div><div class='sec'><span class="bold">Results:</span><p>Using clinically available CT scans, we found modest evidence that CST Injury explains variability in motor impairment (<span class='italic'>R</span><span class='sup'>2</span><span class='sub'>adj</span> = 0.12, <span class='italic'>p</span> = 0.02). None of the participant demographic variables entered the model.</p></div><div class='sec'><span class="bold">Conclusion:</span><p>We show for the first time a relationship between CST Injury and motor impairment using CT scans. Further work is required to evaluate the utility of data derived from clinical CT scans as a biomarker of stroke motor recovery.</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.112" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.112" data-link-target="_blank"></div> </div> </div> </div> <div class="representation overview search" data-prod-id="E4FBDC0BD2FF76CBCEB9C8D2DBBB3270" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/562320B78FEF746DAD9BB6ECBEE0A5D9","productId":"E4FBDC0BD2FF76CBCEB9C8D2DBBB3270","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="E4FBDC0BD2FF76CBCEB9C8D2DBBB3270" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="267881" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/readiness-for-firstinhuman-neuromodulatory-interventions/E4FBDC0BD2FF76CBCEB9C8D2DBBB3270"> Readiness for First-In-Human Neuromodulatory Interventions </a></h3></li> <li></li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Iris Coates McCall&eventCode=SE-AU" class="more-by-this-author ">Iris Coates McCall</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Nicole Minielly&eventCode=SE-AU" class="more-by-this-author ">Nicole Minielly</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Allison Bethune&eventCode=SE-AU" class="more-by-this-author ">Allison Bethune</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Nir Lipsman&eventCode=SE-AU" class="more-by-this-author ">Nir Lipsman</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Patrick J. McDonald&eventCode=SE-AU" class="more-by-this-author ">Patrick J. McDonald</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Judy Illes&eventCode=SE-AU" class="more-by-this-author ">Judy Illes</a> </li> <li> <dl> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 04 June 2020</span><span class="pages">, pp. 785-792</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-E4FBDC0BD2FF76CBCEB9C8D2DBBB3270" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/E4FBDC0BD2FF76CBCEB9C8D2DBBB3270/S0317167120001134a.pdf/readiness_for_firstinhuman_neuromodulatory_interventions.pdf" data-pdf-content-id="E4FBDC0BD2FF76CBCEB9C8D2DBBB3270" target="_blank" aria-label="Download PDF for Readiness for First-In-Human Neuromodulatory Interventions [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/E4FBDC0BD2FF76CBCEB9C8D2DBBB3270/core-reader" target="_blank" aria-label="View HTML full text for Readiness for First-In-Human Neuromodulatory Interventions [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/562320B78FEF746DAD9BB6ECBEE0A5D9","productId":"E4FBDC0BD2FF76CBCEB9C8D2DBBB3270","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="E4FBDC0BD2FF76CBCEB9C8D2DBBB3270" data-container="representation" aria-label="Export citation for Readiness for First-In-Human Neuromodulatory Interventions">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS0317167120001134')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for Readiness for First-In-Human Neuromodulatory Interventions" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/562320B78FEF746DAD9BB6ECBEE0A5D9","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"E4FBDC0BD2FF76CBCEB9C8D2DBBB3270"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS0317167120001134" class="content"> <div class="abstract" data-abstract-type="normal"><div class='sec'><span class="bold">Background:</span><p>Novel neurointerventions present innovative therapeutic approaches to a range of treatment-refractory disorders. We sought to characterize factors that inform and define translational readiness for first-in-human (FIH) neuromodulatory trials.</p></div><div class='sec'><span class="bold">Methods:</span><p>We used a two-part methodology involving a scoping review of the biomedical literature on the readiness of FIH trials for both neurological and non-neurological applications, and semi-structured interviews with stakeholders about decision-making for neuromodulation using magnetic resonance-guided focused ultrasound as a case example.</p></div><div class='sec'><span class="bold">Results:</span><p>One hundred and thirty factors relevant to FIH readiness were identified in the scoping review. <span class='italic'>Trial design, adequacy of preclinical evidence</span>, and <span class='italic'>risk</span> were ubiquitous across biotechnologies. <span class='italic'>Target organ, target function</span>, and inadequacy of <span class='italic'>animal models</span> were dominant in the neurointervention literature. Interview results on the relative importance of these factors reveal divergent values, priorities, and understandings both between patients and clinicians and between patients affected by different conditions.</p></div><div class='sec'><span class="bold">Conclusion:</span><p>Readiness of neurotechnology for FIH trials is defined by a multitude of interacting factors that pertain to clinical and nonclinical priorities, perceptions, and values.</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.113" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.113" data-link-target="_blank"></div> </div> </div> </div> <div class="representation overview search" data-prod-id="703DDF83222309D2D7A194C58B3DA540" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/562320B78FEF746DAD9BB6ECBEE0A5D9","productId":"703DDF83222309D2D7A194C58B3DA540","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="703DDF83222309D2D7A194C58B3DA540" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="326406" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/costeffectiveness-of-5ala-in-highgrade-glioma-surgery-a-qualitybased-systematic-review/703DDF83222309D2D7A194C58B3DA540"> The Cost-Effectiveness of 5-ALA in High-Grade Glioma Surgery: A Quality-Based Systematic Review </a></h3></li> <li></li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Nebras M. Warsi&eventCode=SE-AU" class="more-by-this-author ">Nebras M. Warsi</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Rahel Zewude&eventCode=SE-AU" class="more-by-this-author ">Rahel Zewude</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Brij Karmur&eventCode=SE-AU" class="more-by-this-author ">Brij Karmur</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Neda Pirouzmand&eventCode=SE-AU" class="more-by-this-author ">Neda Pirouzmand</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Laureen Hachem&eventCode=SE-AU" class="more-by-this-author ">Laureen Hachem</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Alireza Mansouri&eventCode=SE-AU" class="more-by-this-author ">Alireza Mansouri</a> </li> <li> <dl> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 24 April 2020</span><span class="pages">, pp. 793-799</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-703DDF83222309D2D7A194C58B3DA540" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/703DDF83222309D2D7A194C58B3DA540/S0317167120000785a.pdf/costeffectiveness_of_5ala_in_highgrade_glioma_surgery_a_qualitybased_systematic_review.pdf" data-pdf-content-id="703DDF83222309D2D7A194C58B3DA540" target="_blank" aria-label="Download PDF for The Cost-Effectiveness of 5-ALA in High-Grade Glioma Surgery: A Quality-Based Systematic Review [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/703DDF83222309D2D7A194C58B3DA540/core-reader" target="_blank" aria-label="View HTML full text for The Cost-Effectiveness of 5-ALA in High-Grade Glioma Surgery: A Quality-Based Systematic Review [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/562320B78FEF746DAD9BB6ECBEE0A5D9","productId":"703DDF83222309D2D7A194C58B3DA540","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="703DDF83222309D2D7A194C58B3DA540" data-container="representation" aria-label="Export citation for The Cost-Effectiveness of 5-ALA in High-Grade Glioma Surgery: A Quality-Based Systematic Review">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS0317167120000785')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for The Cost-Effectiveness of 5-ALA in High-Grade Glioma Surgery: A Quality-Based Systematic Review" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/562320B78FEF746DAD9BB6ECBEE0A5D9","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"703DDF83222309D2D7A194C58B3DA540"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS0317167120000785" class="content"> <div class="abstract" data-abstract-type="normal"><div class='sec'><span class="bold">Background:</span><p>High-grade gliomas (HGGs) are aggressive tumors that inevitably recur due to their diffusely infiltrative nature. Intraoperative adjuncts such as 5-aminolevulinic acid (5-ALA) have shown promise in increasing extent of resection. As the prospect of increased use of 5-ALA rises, a systematic overview of the health economics of this adjunct is critical.</p></div><div class='sec'><span class="bold">Methods:</span><p>Medline, EMBASE, Centre for Reviews and Dissemination, EconPapers, and Cochrane databases were searched for keywords relating to glioma, cost-effectiveness, and 5-ALA. Primary studies reporting on the health economics or cost-effectiveness of 5-ALA compared to white light surgery in HGG were included. Quality was assessed using the <span class='italic'>British Medical Journal</span> guidelines.</p></div><div class='sec'><span class="bold">Results:</span><p>Three studies were identified. All were European and conducted from the perspective of national healthcare systems. Two studies demonstrated the cost-utility of 5-ALA compared to white light (C$12,817 and C$13,508/quality-adjusted life-years (QALYs)). One assessed the cost-utility per gross total resection (C$6,813). Both these values were below the national cost-effectiveness thresholds for each respective study. The third study demonstrated no significant difference in cost of 5-ALA in glioblastoma resection (C$14,732) compared to prior to its routine use (C$15,936). The quality of these studies ranged from moderate to average. None of these studies considered patient perspective or indirect costs in their analysis.</p></div><div class='sec'><span class="bold">Conclusions:</span><p>Growing evidence exists examining the health economic benefit of 5-ALA as an intraoperative adjunct for HGG resection. Additional studies within the Canadian context using 5-ALA, specifically incorporating patient and societal perspectives into the cost-utility analyses, are necessary to solidify this line of evidence.</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.78" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.78" data-link-target="_blank"></div> </div> </div> </div> <div class="representation overview search" data-prod-id="93BE937FCDF20C9F77E415738416374B" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/562320B78FEF746DAD9BB6ECBEE0A5D9","productId":"93BE937FCDF20C9F77E415738416374B","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="93BE937FCDF20C9F77E415738416374B" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="2042495" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/variants-in-chrnb2-and-chrna4-identified-in-patients-with-insular-epilepsy/93BE937FCDF20C9F77E415738416374B"> Variants in <span class="italic">CHRNB2</span> and <span class="italic">CHRNA4</span> Identified in Patients with Insular Epilepsy </a></h3></li> <li></li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Maxime Cadieux-Dion&eventCode=SE-AU" class="more-by-this-author ">Maxime Cadieux-Dion</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Simone Meneghini&eventCode=SE-AU" class="more-by-this-author ">Simone Meneghini</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Chiara Villa&eventCode=SE-AU" class="more-by-this-author ">Chiara Villa</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Dènahin Hinnoutondji Toffa&eventCode=SE-AU" class="more-by-this-author ">Dènahin Hinnoutondji Toffa</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Ronny Wickstrom&eventCode=SE-AU" class="more-by-this-author ">Ronny Wickstrom</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Alain Bouthillier&eventCode=SE-AU" class="more-by-this-author ">Alain Bouthillier</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Ulrika Sandvik&eventCode=SE-AU" class="more-by-this-author ">Ulrika Sandvik</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Bengt Gustavsson&eventCode=SE-AU" class="more-by-this-author ">Bengt Gustavsson</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Ismail Mohamed&eventCode=SE-AU" class="more-by-this-author ">Ismail Mohamed</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Patrick Cossette&eventCode=SE-AU" class="more-by-this-author ">Patrick Cossette</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Romina Combi&eventCode=SE-AU" class="more-by-this-author ">Romina Combi</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Andrea Becchetti&eventCode=SE-AU" class="more-by-this-author ">Andrea Becchetti</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Dang Khoa Nguyen&eventCode=SE-AU" class="more-by-this-author ">Dang Khoa Nguyen</a> </li> <li> <dl> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 15 June 2020</span><span class="pages">, pp. 800-809</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-93BE937FCDF20C9F77E415738416374B" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/93BE937FCDF20C9F77E415738416374B/S0317167120001262a.pdf/variants_in_chrnb2_and_chrna4_identified_in_patients_with_insular_epilepsy.pdf" data-pdf-content-id="93BE937FCDF20C9F77E415738416374B" target="_blank" aria-label="Download PDF for Variants in CHRNB2 and CHRNA4 Identified in Patients with Insular Epilepsy [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/93BE937FCDF20C9F77E415738416374B/core-reader" target="_blank" aria-label="View HTML full text for Variants in CHRNB2 and CHRNA4 Identified in Patients with Insular Epilepsy [Opens in a new window]" 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class="content"> <div class="abstract" data-abstract-type="normal"><div class='sec'><span class="bold">Purpose:</span><p>Our purpose was to determine the role of <span class='italic'>CHRNA4</span> and <span class='italic'>CHRNB2</span> in insular epilepsy.</p></div><div class='sec'><span class="bold">Method:</span><p>We identified two patients with drug-resistant predominantly sleep-related hypermotor seizures, one harboring a heterozygous missense variant (c.77C>T; p. Thr26Met) in the <span class='italic'>CHRNB2</span> gene and the other a heterozygous missense variant (c.1079G>A; p. Arg360Gln) in the <span class='italic'>CHRNA4</span> gene. The patients underwent electrophysiological and neuroimaging studies, and we performed functional characterization of the p. Thr26Met (c.77C>T) in the <span class='italic'>CHRNB2</span> gene.</p></div><div class='sec'><span class="bold">Results:</span><p>We localized the epileptic foci to the left insula in the first case (now seizure-free following epilepsy surgery) and to both insulae in the second case. Based on tools predicting the possible impact of amino acid substitutions on the structure and function of proteins (sorting intolerant from tolerant and PolyPhen-2), variants identified in this report could be deleterious. Functional expression in human cell lines of α4β2 (wild-type), α4β2-Thr26Met (homozygote), and α4β2/β2-Thr26Met (heterozygote) nicotinic acetylcholine receptors revealed that the mutant subunit led to significantly higher whole-cell nicotinic currents. This feature was observed in both homo- and heterozygous conditions and was not accompanied by major alterations of the current reversal potential or the shape of the concentration-response relation.</p></div><div class='sec'><span class="bold">Conclusions:</span><p>This study suggests that variants in <span class='italic'>CHRNB2</span> and <span class='italic'>CHRNA4</span>, initially linked to autosomal dominant nocturnal frontal lobe epilepsy, are also found in patients with predominantly sleep-related insular epilepsy. Although the reported variants should be considered of unknown clinical significance for the moment, identification of additional similar cases and further functional studies could eventually strengthen this association.</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.126" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.126" data-link-target="_blank"></div> </div> </div> </div> <div class="representation overview search" data-prod-id="63FE2605642F885064403CA07FE8E406" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/562320B78FEF746DAD9BB6ECBEE0A5D9","productId":"63FE2605642F885064403CA07FE8E406","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="63FE2605642F885064403CA07FE8E406" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="200260" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/national-spinal-muscular-atrophy-registry-for-realworld-evidence/63FE2605642F885064403CA07FE8E406"> A National Spinal Muscular Atrophy Registry for Real-World Evidence </a></h3></li> <li></li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Victoria L. 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The first-approved disease-modifying therapy for SMA, nusinursen, was approved by Health Canada, as well as by American and European regulatory agencies following positive clinical trial outcomes. The trials were conducted in a narrow pediatric population defined by age, severity, and genotype. Broad approval of therapy necessitates close follow-up of potential rare adverse events and effectiveness in the larger real-world population.</p> </div> <div class='sec'> <span class="bold">Methods:</span> <p>The Canadian Neuromuscular Disease Registry (CNDR) undertook an iterative multi-stakeholder process to expand the existing SMA dataset to capture items relevant to patient outcomes in a post-marketing environment. The CNDR SMA expanded registry is a longitudinal, prospective, observational study of patients with SMA in Canada designed to evaluate the safety and effectiveness of novel therapies and provide practical information unattainable in trials.</p> </div> <div class='sec'> <span class="bold">Results:</span> <p>The consensus expanded dataset includes items that address therapy effectiveness and safety and is collected in a multicenter, prospective, observational study, including SMA patients regardless of therapeutic status. The expanded dataset is aligned with global datasets to facilitate collaboration. Additionally, consensus dataset development aimed to standardize appropriate outcome measures across the network and broader Canadian community. Prospective outcome studies, data use, and analyses are independent of the funding partner.</p> </div> <div class='sec'> <span class="bold">Conclusion:</span> <p>Prospective outcome data collected will provide results on safety and effectiveness in a post-therapy approval era. These data are essential to inform improvements in care and access to therapy for all SMA patients.</p> </div> </div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.111" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.111" data-link-target="_blank"></div> </div> </div> </div> <div class="representation overview search" data-prod-id="64363CC5130092B9F9E0710E86AB1982" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/562320B78FEF746DAD9BB6ECBEE0A5D9","productId":"64363CC5130092B9F9E0710E86AB1982","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="64363CC5130092B9F9E0710E86AB1982" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="116410" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/poor-yield-of-routine-transthyretin-screening-in-patients-with-idiopathic-neuropathy/64363CC5130092B9F9E0710E86AB1982"> Poor Yield of Routine Transthyretin Screening in Patients with Idiopathic Neuropathy </a></h3></li> <li></li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Dina Namiranian&eventCode=SE-AU" class="more-by-this-author ">Dina Namiranian</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Colin Chalk&eventCode=SE-AU" class="more-by-this-author ">Colin Chalk</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Rami Massie&eventCode=SE-AU" class="more-by-this-author ">Rami Massie</a> </li> <li> <dl> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 04 June 2020</span><span class="pages">, pp. 816-819</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-64363CC5130092B9F9E0710E86AB1982" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> <span class="icon access open-access cursorDefault"></span>Open access </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/64363CC5130092B9F9E0710E86AB1982/S0317167120001146a.pdf/poor_yield_of_routine_transthyretin_screening_in_patients_with_idiopathic_neuropathy.pdf" data-pdf-content-id="64363CC5130092B9F9E0710E86AB1982" target="_blank" aria-label="Download PDF for Poor Yield of Routine Transthyretin Screening in Patients with Idiopathic Neuropathy [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/64363CC5130092B9F9E0710E86AB1982/core-reader" target="_blank" aria-label="View HTML full text for Poor Yield of Routine Transthyretin Screening in Patients with Idiopathic Neuropathy [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/562320B78FEF746DAD9BB6ECBEE0A5D9","productId":"64363CC5130092B9F9E0710E86AB1982","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); 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Although classically described as rapidly progressive and life-threatening, recent studies on TTR-FAP show significant genetic and phenotypic heterogeneity depending on geographic localization. In light of new therapeutic advances and their implication for patient management, the aim of our study was to determine the prevalence of TTR-FAP within patients with idiopathic neuropathy in a North American population.</p></div><div class='sec'><span class="bold">Methods:</span><p>We sequenced the TTR gene in a cohort of patients with idiopathic neuropathy. Genetic screening was performed in 110 patients from two neuromuscular clinics in Montreal, Canada.</p></div><div class='sec'><span class="bold">Results:</span><p>No variants of unknown significance or pathogenic mutations were detected in the TTR gene.</p></div><div class='sec'><span class="bold">Conclusion:</span><p>Our study confirms that TTR-FAP is a rare entity in our patient population, and that diagnostic yield of screening all patients with idiopathic neuropathy is very low.</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.114" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.114" data-link-target="_blank"></div> </div> </div> </div> <h4 class="journal-article-listing-type heading_12 margin-bottom">Neuroimaging Highlights</h4> <div class="representation overview search" data-prod-id="BE7F122B1224B95CD7BC397954B7D9AE" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/562320B78FEF746DAD9BB6ECBEE0A5D9","productId":"BE7F122B1224B95CD7BC397954B7D9AE","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="BE7F122B1224B95CD7BC397954B7D9AE" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="430874" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/congenital-herniation-of-the-gyrus-rectus-resulting-in-compressive-optic-neuropathy/BE7F122B1224B95CD7BC397954B7D9AE"> Congenital Herniation of the Gyrus Rectus Resulting in Compressive Optic Neuropathy </a></h3></li> <li></li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Kia Gilani&eventCode=SE-AU" class="more-by-this-author ">Kia Gilani</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Pejman Jabehdar Maralani&eventCode=SE-AU" class="more-by-this-author ">Pejman Jabehdar Maralani</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Arun NE Sundaram&eventCode=SE-AU" class="more-by-this-author ">Arun NE Sundaram</a> </li> <li> <dl> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 06 July 2020</span><span class="pages">, pp. 820-821</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-BE7F122B1224B95CD7BC397954B7D9AE" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> </li> </ul> </li> <li> <a 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xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">extract</span> </div> </button> <div id="abstractS0317167120001365" class="content"> <div class="abstract" data-abstract-type="extract"><p>We report a 34-year-old male with a previously uninvestigated lifelong blindness of the right eye from compressive optic neuropathy secondary to congenital herniation of the gyrus rectus (HGR). His past medical history was otherwise unremarkable, with no history of prior head or ocular trauma. On examination, he had no light perception in the right eye, right relative afferent pupillary defect (RAPD), and primary optic atrophy. His left eye had normal visual acuity, color vision, and a healthy optic disc. There was a sensory exotropia in the right eye; however, extraocular movements were intact and the remainder of his neurological exam was normal. MRI revealed compression of the prechiasmatic right optic nerve from HGR and atrophy of the right optic nerve and optic chiasm (Figures 1 and 2), without any parenchymal mass lesions. There were no signal abnormalities in the optic nerves or the chiasm.</p></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.136" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.136" data-link-target="_blank"></div> </div> </div> </div> <div class="representation overview search" data-prod-id="6697DEA40D76A0FDA5EB2584D91E484E" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/562320B78FEF746DAD9BB6ECBEE0A5D9","productId":"6697DEA40D76A0FDA5EB2584D91E484E","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="6697DEA40D76A0FDA5EB2584D91E484E" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="334640" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/supranuclear-horizontal-gaze-palsy-following-anterior-internal-capsule-hemorrhage/6697DEA40D76A0FDA5EB2584D91E484E"> Supranuclear Horizontal Gaze Palsy Following Anterior Internal Capsule Hemorrhage </a></h3></li> <li></li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Nathan Chu&eventCode=SE-AU" class="more-by-this-author ">Nathan Chu</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Grayson Beecher&eventCode=SE-AU" class="more-by-this-author ">Grayson Beecher</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Mohammed Wasif Hussain&eventCode=SE-AU" class="more-by-this-author ">Mohammed Wasif Hussain</a> </li> <li> <dl> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 08 June 2020</span><span class="pages">, pp. 822-823</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-6697DEA40D76A0FDA5EB2584D91E484E" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/6697DEA40D76A0FDA5EB2584D91E484E/S0317167120001183a.pdf/supranuclear_horizontal_gaze_palsy_following_anterior_internal_capsule_hemorrhage.pdf" data-pdf-content-id="6697DEA40D76A0FDA5EB2584D91E484E" target="_blank" aria-label="Download PDF for Supranuclear Horizontal Gaze Palsy Following Anterior Internal Capsule Hemorrhage [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/6697DEA40D76A0FDA5EB2584D91E484E/core-reader" target="_blank" aria-label="View HTML full text for Supranuclear Horizontal Gaze Palsy Following Anterior Internal Capsule Hemorrhage [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/562320B78FEF746DAD9BB6ECBEE0A5D9","productId":"6697DEA40D76A0FDA5EB2584D91E484E","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="6697DEA40D76A0FDA5EB2584D91E484E" data-container="representation" aria-label="Export citation for Supranuclear Horizontal Gaze Palsy Following Anterior Internal Capsule Hemorrhage">Export citation </a></li> </ul> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.118" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.118" data-link-target="_blank"></div> </div> </div> </div> <div class="representation overview search" data-prod-id="991B41C64D654A32504889646E5BB4DA" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/562320B78FEF746DAD9BB6ECBEE0A5D9","productId":"991B41C64D654A32504889646E5BB4DA","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="991B41C64D654A32504889646E5BB4DA" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="184421" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/superior-oblique-myokymia-presumed-due-to-large-posterior-fossa-arteriovenous-malformation/991B41C64D654A32504889646E5BB4DA"> Superior Oblique Myokymia Presumed Due to Large Posterior Fossa Arteriovenous Malformation </a></h3></li> <li></li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Laura Donaldson&eventCode=SE-AU" class="more-by-this-author ">Laura Donaldson</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Brian van Adel&eventCode=SE-AU" class="more-by-this-author ">Brian van Adel</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Amadeo R. Rodriguez&eventCode=SE-AU" class="more-by-this-author ">Amadeo R. Rodriguez</a> </li> <li> <dl> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 05 August 2020</span><span class="pages">, pp. 824-825</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-991B41C64D654A32504889646E5BB4DA" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/991B41C64D654A32504889646E5BB4DA/S0317167120001250a.pdf/superior_oblique_myokymia_presumed_due_to_large_posterior_fossa_arteriovenous_malformation.pdf" data-pdf-content-id="991B41C64D654A32504889646E5BB4DA" target="_blank" aria-label="Download PDF for Superior Oblique Myokymia Presumed Due to Large Posterior Fossa Arteriovenous Malformation [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/991B41C64D654A32504889646E5BB4DA/core-reader" target="_blank" aria-label="View HTML full text for Superior Oblique Myokymia Presumed Due to Large Posterior Fossa Arteriovenous Malformation [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/562320B78FEF746DAD9BB6ECBEE0A5D9","productId":"991B41C64D654A32504889646E5BB4DA","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="991B41C64D654A32504889646E5BB4DA" data-container="representation" aria-label="Export citation for Superior Oblique Myokymia Presumed Due to Large Posterior Fossa Arteriovenous Malformation">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS0317167120001250')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Extract for Superior Oblique Myokymia Presumed Due to Large Posterior Fossa Arteriovenous Malformation" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/562320B78FEF746DAD9BB6ECBEE0A5D9","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"991B41C64D654A32504889646E5BB4DA"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">extract</span> </div> </button> <div id="abstractS0317167120001250" class="content"> <div class="abstract" data-abstract-type="extract"><p>A 26-year-old female presented with a complaint of intermittent oscillopsia and binocular vertical diplopia for the past 5 years. Over the past several months, she had noticed intermittent pulsatile tinnitus. She was otherwise healthy with no previous history of trauma and had no other visual or neurologic complaints. In Neuro-ophthalmology clinic, she was found to have 20/15 vision in both eyes with full ocular motility. There was a small exophoria in primary position and small esophoria in downgaze. Her slit lamp and fundus examinations were normal. During the assessment, the left eye was noted to undergo high-frequency, small amplitude incyclotorsional oscillations for a few seconds at a time (Video 1 in the supplementary material), which she was able to provoke by looking down. The diagnosis of superior oblique myokymia was made, and an MRI/MRA of the brain was requested.</p></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.125" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.125" data-link-target="_blank"></div> </div> </div> </div> <div class="representation overview search" data-prod-id="C291203928E1B20A3049B60FDBAF9C7C" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/562320B78FEF746DAD9BB6ECBEE0A5D9","productId":"C291203928E1B20A3049B60FDBAF9C7C","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="C291203928E1B20A3049B60FDBAF9C7C" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="195598" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/threedimensional-computed-tomography-reconstruction-unmasks-shunt-disconnection-in-a-child/C291203928E1B20A3049B60FDBAF9C7C"> Three-Dimensional Computed Tomography Reconstruction Unmasks Shunt Disconnection in a Child </a></h3></li> <li></li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Jignesh K. Tailor&eventCode=SE-AU" class="more-by-this-author ">Jignesh K. Tailor</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Ian C. Coulter&eventCode=SE-AU" class="more-by-this-author ">Ian C. Coulter</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Michael C. Dewan&eventCode=SE-AU" class="more-by-this-author ">Michael C. Dewan</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Helen M. Branson&eventCode=SE-AU" class="more-by-this-author ">Helen M. Branson</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Peter B. Dirks&eventCode=SE-AU" class="more-by-this-author ">Peter B. Dirks</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=James T. Rutka&eventCode=SE-AU" class="more-by-this-author ">James T. Rutka</a> </li> <li> <dl> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 04 June 2020</span><span class="pages">, pp. 826-827</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-C291203928E1B20A3049B60FDBAF9C7C" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/C291203928E1B20A3049B60FDBAF9C7C/S0317167120001109a.pdf/threedimensional_computed_tomography_reconstruction_unmasks_shunt_disconnection_in_a_child.pdf" data-pdf-content-id="C291203928E1B20A3049B60FDBAF9C7C" target="_blank" aria-label="Download PDF for Three-Dimensional Computed Tomography Reconstruction Unmasks Shunt Disconnection in a Child [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/C291203928E1B20A3049B60FDBAF9C7C/core-reader" target="_blank" aria-label="View HTML full text for Three-Dimensional Computed Tomography Reconstruction Unmasks Shunt Disconnection in a Child [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/562320B78FEF746DAD9BB6ECBEE0A5D9","productId":"C291203928E1B20A3049B60FDBAF9C7C","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="C291203928E1B20A3049B60FDBAF9C7C" data-container="representation" aria-label="Export citation for Three-Dimensional Computed Tomography Reconstruction Unmasks Shunt Disconnection in a Child">Export citation </a></li> </ul> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.110" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.110" data-link-target="_blank"></div> </div> </div> </div> <div class="representation overview search" data-prod-id="E143D880EA729C6B554732054C1C20D6" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/562320B78FEF746DAD9BB6ECBEE0A5D9","productId":"E143D880EA729C6B554732054C1C20D6","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="E143D880EA729C6B554732054C1C20D6" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="420222" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/megalencephalycapillary-malformationpolymicrogyria-with-cerebral-venous-thrombosis/E143D880EA729C6B554732054C1C20D6"> Megalencephaly–Capillary Malformation–Polymicrogyria with Cerebral Venous Thrombosis </a></h3></li> <li></li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Olivier Fortin&eventCode=SE-AU" class="more-by-this-author ">Olivier Fortin</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Mohammed Ashour&eventCode=SE-AU" class="more-by-this-author ">Mohammed Ashour</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Caroline Lacroix&eventCode=SE-AU" class="more-by-this-author ">Caroline Lacroix</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Christine A. Sabapathy&eventCode=SE-AU" class="more-by-this-author ">Christine A. Sabapathy</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Kenneth A. Myers&eventCode=SE-AU" class="more-by-this-author ">Kenneth A. Myers</a> </li> <li> <dl> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 23 June 2020</span><span class="pages">, pp. 828-829</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-E143D880EA729C6B554732054C1C20D6" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/E143D880EA729C6B554732054C1C20D6/S0317167120001274a.pdf/megalencephalycapillary_malformationpolymicrogyria_with_cerebral_venous_thrombosis.pdf" data-pdf-content-id="E143D880EA729C6B554732054C1C20D6" target="_blank" aria-label="Download PDF for Megalencephaly–Capillary Malformation–Polymicrogyria with Cerebral Venous Thrombosis [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/E143D880EA729C6B554732054C1C20D6/core-reader" target="_blank" aria-label="View HTML full text for Megalencephaly–Capillary Malformation–Polymicrogyria with Cerebral Venous Thrombosis [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/562320B78FEF746DAD9BB6ECBEE0A5D9","productId":"E143D880EA729C6B554732054C1C20D6","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="E143D880EA729C6B554732054C1C20D6" data-container="representation" aria-label="Export citation for Megalencephaly–Capillary Malformation–Polymicrogyria with Cerebral Venous Thrombosis">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS0317167120001274')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Extract for Megalencephaly–Capillary Malformation–Polymicrogyria with Cerebral Venous Thrombosis" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/562320B78FEF746DAD9BB6ECBEE0A5D9","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"E143D880EA729C6B554732054C1C20D6"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">extract</span> </div> </button> <div id="abstractS0317167120001274" class="content"> <div class="abstract" data-abstract-type="extract"><p>Megalencephaly–capillary malformation–polymicrogyria (MCAP) syndrome (OMIM #602501) is characterized by megalencephaly, midline capillary malformations, and cortical malformations. This genetic overgrowth syndrome is associated with mosaic gain-of-function pathogenic <span class='italic'>PIK3CA</span> variants (OMIM #171834).</p></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.127" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.127" data-link-target="_blank"></div> </div> </div> </div> <h4 class="journal-article-listing-type heading_12 margin-bottom">Brief Communications</h4> <div class="representation overview search" data-prod-id="0BB685B708FFF75050C868D803CEB753" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/562320B78FEF746DAD9BB6ECBEE0A5D9","productId":"0BB685B708FFF75050C868D803CEB753","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="0BB685B708FFF75050C868D803CEB753" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="211672" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/access-to-allied-health-care-services-in-canadian-interdisciplinary-complex-nerve-injury-programs/0BB685B708FFF75050C868D803CEB753"> Access to Allied Health Care Services in Canadian Interdisciplinary Complex Nerve Injury Programs </a></h3></li> <li></li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Kristine M. Chapman&eventCode=SE-AU" class="more-by-this-author ">Kristine M. Chapman</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Chris Doherty&eventCode=SE-AU" class="more-by-this-author ">Chris Doherty</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Sean G. Bristol&eventCode=SE-AU" class="more-by-this-author ">Sean G. Bristol</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Russell O’Connor&eventCode=SE-AU" class="more-by-this-author ">Russell O’Connor</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Michael J. Berger&eventCode=SE-AU" class="more-by-this-author ">Michael J. Berger</a> </li> <li> <dl> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 26 May 2020</span><span class="pages">, pp. 830-833</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-0BB685B708FFF75050C868D803CEB753" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/0BB685B708FFF75050C868D803CEB753/S0317167120000980a.pdf/access_to_allied_health_care_services_in_canadian_interdisciplinary_complex_nerve_injury_programs.pdf" data-pdf-content-id="0BB685B708FFF75050C868D803CEB753" target="_blank" aria-label="Download PDF for Access to Allied Health Care Services in Canadian Interdisciplinary Complex Nerve Injury Programs [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/0BB685B708FFF75050C868D803CEB753/core-reader" target="_blank" aria-label="View HTML full text for Access to Allied Health Care Services in Canadian Interdisciplinary Complex Nerve Injury Programs [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/562320B78FEF746DAD9BB6ECBEE0A5D9","productId":"0BB685B708FFF75050C868D803CEB753","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="0BB685B708FFF75050C868D803CEB753" data-container="representation" aria-label="Export citation for Access to Allied Health Care Services in Canadian Interdisciplinary Complex Nerve Injury Programs">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS0317167120000980')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for Access to Allied Health Care Services in Canadian Interdisciplinary Complex Nerve Injury Programs" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/562320B78FEF746DAD9BB6ECBEE0A5D9","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"0BB685B708FFF75050C868D803CEB753"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS0317167120000980" class="content"> <div class="abstract" data-abstract-type="normal"><p>Nerve transfer surgery for patients with nerve and spinal cord injuries can result in dramatic functional improvements. As a result, interdisciplinary complex nerve injury programs (CNIPs) have been established in many Canadian centers, providing electrodiagnostic and surgical consultations in a single encounter. We sought to determine which allied health care services are included in Canadian CNIPs, at the 3rd Annual Canadian Peripheral Nerve Symposium. Twenty CNIPs responded to a brief survey and reported access as follows: occupational therapy = 60%, physiotherapy = 40%, social work = 20%, and mental health = 10%. Access to allied health services is variable in CNIPs across Canada, possibly resulting in heterogeneity in patient care.</p></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.98" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.98" data-link-target="_blank"></div> </div> </div> </div> <div class="representation overview search" data-prod-id="49D626B381F837AA6072F9BB010F4E99" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/562320B78FEF746DAD9BB6ECBEE0A5D9","productId":"49D626B381F837AA6072F9BB010F4E99","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="49D626B381F837AA6072F9BB010F4E99" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="140950" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/access-to-focal-spasticity-care-a-cross-canada-survey-of-physiatrists/49D626B381F837AA6072F9BB010F4E99"> Access to Focal Spasticity Care: A Cross Canada Survey of Physiatrists </a></h3></li> <li></li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Kevin E. Liang&eventCode=SE-AU" class="more-by-this-author ">Kevin E. Liang</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Pham Vivian Ngo&eventCode=SE-AU" class="more-by-this-author ">Pham Vivian Ngo</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Paul Winston&eventCode=SE-AU" class="more-by-this-author ">Paul Winston</a> </li> <li> <dl> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 04 June 2020</span><span class="pages">, pp. 834-838</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-49D626B381F837AA6072F9BB010F4E99" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/49D626B381F837AA6072F9BB010F4E99/S0317167120001080a.pdf/access_to_focal_spasticity_care_a_cross_canada_survey_of_physiatrists.pdf" data-pdf-content-id="49D626B381F837AA6072F9BB010F4E99" target="_blank" aria-label="Download PDF for Access to Focal Spasticity Care: A Cross Canada Survey of Physiatrists [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/49D626B381F837AA6072F9BB010F4E99/core-reader" target="_blank" aria-label="View HTML full text for Access to Focal Spasticity Care: A Cross Canada Survey of Physiatrists [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/562320B78FEF746DAD9BB6ECBEE0A5D9","productId":"49D626B381F837AA6072F9BB010F4E99","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="49D626B381F837AA6072F9BB010F4E99" data-container="representation" aria-label="Export citation for Access to Focal Spasticity Care: A Cross Canada Survey of Physiatrists">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS0317167120001080')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for Access to Focal Spasticity Care: A Cross Canada Survey of Physiatrists" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/562320B78FEF746DAD9BB6ECBEE0A5D9","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"49D626B381F837AA6072F9BB010F4E99"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS0317167120001080" class="content"> <div class="abstract" data-abstract-type="normal"><p>Successful management of focal spasticity requires access to botulinum toxin type A (BoNT-A) injections, physiotherapy, occupational therapy, and orthoses/bracing. To assess the quality of focal spasticity care across Canada, we sent a survey consisting of 22 questions to physiatrists involved in the management of outpatient spasticity. Thirty-four physiatrists from all 10 provinces responded to the survey. Wait time for BoNT-A treatment averaged 12.7 weeks from time of referral across Canada. More than 75% of patients faced barriers to obtaining physical therapy and orthoses. Access to best quality care for spasticity patients across Canada varies widely.</p></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.108" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.108" data-link-target="_blank"></div> </div> </div> </div> </div> </div> <hr/> <div class="pagination-centered" data-test-id="paginationSearchResult"> <p class="paragraph_05 margin-bottom-small">Page 1 of 2</p> <ul class="pagination"> <li class="unavailable"><span class="in-active-item">First</span></li> <li class="unavailable"><span class="in-active-item">« Prev</span></li> <li class="current"><a href="?pageNum=1" data-page-number="1" aria-label="Page 1">1</a></li> <li class=""><a 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Canadian Journal of Neurological Sciences: Volume 47 - Issue 6 | Cambridge Core