睡眠時に脳内の老廃物を洗い流すシステム、研究によってかなりわかってきていた→睡眠薬がその「脳の掃除」を妨げているおそれも

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</a> <h1 class="entry_title"> <a class="info_title emj" href="https://togetter.com/li/2526981" title="睡眠時に脳内の老廃物を洗い流すシステム、研究によってかなりわかってきていた→睡眠薬がその「脳の掃除」を妨げているおそれも">睡眠時に脳内の老廃物を洗い流すシステム、研究によってかなりわかってきていた→睡眠薬がその「脳の掃除」を妨げているおそれも</a> </h1> <p class="entry_tags tag_box"> <a class="rad_btn tag_type_1 " href="/t/%E3%83%8A%E3%82%B7%E3%83%A7%E3%82%B8%E3%82%AA" data-ga="inbound_listtag" rel="tag">ナショジオ</a> <a class="rad_btn tag_type_1 " href="/t/%E7%9D%A1%E7%9C%A0" data-ga="inbound_listtag" rel="tag">睡眠</a> <a class="rad_btn tag_type_1 " href="/t/%E8%A1%80%E7%AE%A1" data-ga="inbound_listtag" rel="tag">血管</a> <a class="rad_btn tag_type_1 " href="/t/%E8%80%81%E5%BB%83%E7%89%A9" data-ga="inbound_listtag" rel="tag">老廃物</a> <a class="rad_btn tag_type_1 " href="/t/%E3%83%8E%E3%83%AB%E3%82%A2%E3%83%89%E3%83%AC%E3%83%8A%E3%83%AA%E3%83%B3" data-ga="inbound_listtag" rel="tag">ノルアドレナリン</a> <a class="rad_btn tag_type_1 " href="/t/%E7%9D%A1%E7%9C%A0%E8%96%AC" data-ga="inbound_listtag" rel="tag">睡眠薬</a> <a 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老廃物を洗い流すシステムへの影響に「衝撃を受けた」と研究者。睡眠薬を使っている人は今回の結果をどう受け止めればよいのでしょうか。解説します。</span> <a href="https://t.co/bWVf6GWZRF" target="_blank" rel="noreferrer">natgeo.nikkeibp.co.jp/atcl/news/25/0…</a></p> <span class='status'> <span class="intent"></span> <span> <a class="link" href="https://x.com/NatGeoMagJP/status/1901469104311279622" target="_blank" rel="noreferrer">2025-03-17 12:02:16</a> </span> </span> </div> <div class='list_box type_url clearfix'> <div class="thumb"> <a href="https://natgeo.nikkeibp.co.jp/atcl/news/25/031300141/" target="_blank" rel="nofollow noopener"> <img class="lazy " data-s="https://pimg.togetter.com/bf9ee4dbbbdd2e6a0d2c21fea8b6a79233733287/68747470733a2f2f6e617467656f2e6e696b6b656962702e636f2e6a702f6174636c2f6e6577732f32352f3033313330303134312f70685f7468756d622e6a7067?w=250&t=c" src="https://s.tgstc.com/static/web/p.gif" data-e="https://s.tgstc.com/static/web/img/noimage200.png" /> </a> </div> <span class="content"> <span class="label">リンク</span> <span class="site_name"> natgeo.nikkeibp.co.jp </span> </span> <span class="title"> <a href="https://natgeo.nikkeibp.co.jp/atcl/news/25/031300141/" target="_blank" rel="nofollow noopener"> 睡眠薬が脳の掃除を妨げているおそれ、認知症とも関連、最新研究 </a> </span> <span class="desc"> 私たちが眠っている間、脳は周期的に老廃物を洗い流している。新しい研究によると、ある種の薬は、この重要な夜の掃除の妨げになることがあるという。 </span> <span class="site_data"> <span class="http-bookmark bindclick" data-href="https://natgeo.nikkeibp.co.jp/atcl/news/25/031300141/">29 users</span> <span class="count_facebook bindclick" data-href="https://natgeo.nikkeibp.co.jp/atcl/news/25/031300141/"> <svg class="svg-icon fa-facebook-square"><use xlink:href="#facebook-square" /></svg>428</span> </span> </div> <div class='list_box type_tweet impl_profile' data-index='2' data-id='1901472241126146321'> <span> <a class="user_link" rel="noreferrer" href='https://x.com/u1ro_ishikawa' target='_blank'> <img class="lzpk " data-s="4" src="https://s.tgstc.com/static/web/p.gif" data-e="3" /> <strong class="emj">いしかわ@FSM司祭</strong> <span class="status_name">@u1ro_ishikawa</span> </a> </span> <p class='tweet emj'><span class="f17 c10">へぇー！　「老廃物を洗い流すシステム」の仕組みってこんなにわかってきたんか！眠る→ノルアドレナリン放出→脳血管収縮→血液量が減って脳脊髄液流入→ノルアドレナリン減少で血液再度還流→老廃物を含む脳脊髄液が脳から押し出されるこの仕組み組み込んだ睡眠薬作れんかな電気刺激とか <a href="https://t.co/XqQbc6SGj7" target="_blank" rel="noreferrer">x.com/NatGeoMagJP/st…</a></span></p> <span class='status'> <span class="intent"></span> <span> <a class="link" href="https://x.com/u1ro_ishikawa/status/1901472241126146321" target="_blank" rel="noreferrer">2025-03-17 12:14:44</a> </span> </span> </div> <div class='list_box type_tweet impl_profile' data-index='3' data-id='1901472927369101692'> <span> <a class="user_link" rel="noreferrer" href='https://x.com/u1ro_ishikawa' target='_blank'> <img class="lzpk " data-s="4" src="https://s.tgstc.com/static/web/p.gif" data-e="3" /> <strong class="emj">いしかわ@FSM司祭</strong> <span class="status_name">@u1ro_ishikawa</span> </a> </span> <p class='tweet emj'><span class="f17 c10">あ、記事にもあるけど「じゃ睡眠薬意味ないじゃん！」ってなるのは全然早計だからね！まだマウスでしか結果出てないし、老廃物洗い流し以外の作用もあるし、認知症リスク云々もまだはっきりしてないし</span></p> <span class='status'> <span class="intent"></span> <span> <a class="link" href="https://x.com/u1ro_ishikawa/status/1901472927369101692" target="_blank" rel="noreferrer">2025-03-17 12:17:28</a> </span> </span> </div> <div class='list_box type_tweet impl_profile' data-index='4' data-id='1901488599419551773'> <span> <a class="user_link" rel="noreferrer" href='https://x.com/u1ro_ishikawa' target='_blank'> <img class="lzpk " data-s="4" src="https://s.tgstc.com/static/web/p.gif" data-e="3" /> <strong class="emj">いしかわ@FSM司祭</strong> <span class="status_name">@u1ro_ishikawa</span> </a> </span> <p class='tweet emj'><span class="f17 c10">脳の老廃物の除去に脳脊髄液が関わってるってことは、脳脊髄液減少症なんかが脳に及ぼす悪影響の機序も老廃物除去に関連してるんやろか随分前に平常時の圧が関係してるんではみたいな仮説読んだ気がするけど、こっちの機序もあるなら相当影響でかい気が髄液漏れてるっぽい鶴見中尉大丈夫？ <a href="https://t.co/md3Pp9NOQb" target="_blank" rel="noreferrer">pic.x.com/md3Pp9NOQb</a></span></p> <span class='status'> <span class="intent"></span> <span> <a class="link" href="https://x.com/u1ro_ishikawa/status/1901488599419551773" target="_blank" rel="noreferrer">2025-03-17 13:19:44</a> </span> </span> <div class="list_photo_box"> <figure class='list_photo'> <img class="lzpk " data-s="5" src="https://s.tgstc.com/static/web/p.gif" data-e="6" style="height: 127px; width: 395px;"/> </figure> </div> </div> <div class='list_box type_tweet impl_profile' data-index='5' data-id='1901857080941891987'> <span> <a class="user_link" rel="noreferrer" href='https://x.com/u1ro_ishikawa' target='_blank'> <img class="lzpk " data-s="4" src="https://s.tgstc.com/static/web/p.gif" data-e="3" /> <strong class="emj">いしかわ@FSM司祭</strong> <span class="status_name">@u1ro_ishikawa</span> </a> </span> <p class='tweet emj'><span class="f17 c10">みんな脳科学好きやなあ、てことで宣伝走ることで脳のいろんなとこが活性化するって話を、医博2人がエビデンスを紐解きながら解説しました。ジョギング続かない人も「スロージョギング」って負担小さい走り方なのでできる。かも仕事に効く、脳を鍛える、スロージョギング <a href="https://t.co/Tmo8SPZkvW" target="_blank" rel="noreferrer">amzn.asia/d/cw565rb</a></span></p> <span class='status'> <span class="intent"></span> <span> <a class="link" href="https://x.com/u1ro_ishikawa/status/1901857080941891987" target="_blank" rel="noreferrer">2025-03-18 13:43:57</a> </span> </span> </div> <div class='list_box'> <span class="title"> <a href="https://www.amazon.co.jp/exec/obidos/ASIN/B009Z7HV0G/togetter0804-22/ref=nosim/" target="_blank"> 仕事に効く、脳を鍛える、スロージョギング (角川SSC新書) </a> </span> <div class="quote_box clearfix"> <a href="https://www.amazon.co.jp/exec/obidos/ASIN/B009Z7HV0G/togetter0804-22/ref=nosim/" target="_blank"> <img src='https://images-na.ssl-images-amazon.com/images/I/51-AWLXTpsL._SL400_.jpg'/> </a> <p>久保田競,田中宏暁</p> </div> </div> <div class='list_box type_tweet impl_profile' data-index='7' data-id='1901568876711665837'> <span> <a class="user_link" rel="noreferrer" href='https://x.com/bitter_orange' target='_blank'> <img class="lzpk " data-s="7" src="https://s.tgstc.com/static/web/p.gif" data-e="3" /> <strong class="emj">づけまぐる。@台湾カメラマン</strong> <span class="status_name">@bitter_orange</span> </a> </span> <p class='tweet emj'><a href="https://x.com/u1ro_ishikawa" target="_blank" rel="noreferrer">@u1ro_ishikawa</a> 素直にノルアドレナリン入れたらダメなんですかね…</p> <span class='status'> <span class="intent"></span> <span> <a class="link" href="https://x.com/bitter_orange/status/1901568876711665837" target="_blank" rel="noreferrer">2025-03-17 18:38:44</a> </span> </span> </div> <div class='list_box type_tweet impl_profile' data-index='8' data-id='1901571459195302169'> <span> <a class="user_link" rel="noreferrer" href='https://x.com/u1ro_ishikawa' target='_blank'> <img class="lzpk " data-s="4" src="https://s.tgstc.com/static/web/p.gif" data-e="3" /> <strong class="emj">いしかわ@FSM司祭</strong> <span class="status_name">@u1ro_ishikawa</span> </a> </span> <p class='tweet emj'><span class="f17 c10"><a href="https://x.com/bitter_orange" target="_blank" rel="noreferrer">@bitter_orange</a> たぶんそれでいいんですが、「こうした血管の拡張と収縮は、約50秒周期のリズミカルな振動として測定された」とあるので、その短時間の周期をノルアドレナリンの投与で作ることができるか、ってのが次の課題になりそう薬物的にやるより分泌器官への刺激で自律的にさせるほうがうまくいくんかな、とか</span></p> <span class='status'> <span class="intent"></span> <span> <a class="link" href="https://x.com/u1ro_ishikawa/status/1901571459195302169" target="_blank" rel="noreferrer">2025-03-17 18:49:00</a> </span> </span> </div> <div class='list_box type_tweet impl_profile' data-index='9' data-id='1901571936859107410'> <span> <a class="user_link" rel="noreferrer" href='https://x.com/bitter_orange' target='_blank'> <img class="lzpk " data-s="7" src="https://s.tgstc.com/static/web/p.gif" data-e="3" /> <strong class="emj">づけまぐる。@台湾カメラマン</strong> <span class="status_name">@bitter_orange</span> </a> </span> <p class='tweet emj'><a href="https://x.com/u1ro_ishikawa" target="_blank" rel="noreferrer">@u1ro_ishikawa</a> 何段階か前の前駆物質みたいなのを混ぜ込んだ方がよさそうですね…</p> <span class='status'> <span class="intent"></span> <span> <a class="link" href="https://x.com/bitter_orange/status/1901571936859107410" target="_blank" rel="noreferrer">2025-03-17 18:50:53</a> </span> </span> </div> <div class='list_box type_tweet impl_profile' data-index='10' data-id='1901572823011012678'> <span> <a class="user_link" rel="noreferrer" href='https://x.com/u1ro_ishikawa' target='_blank'> <img class="lzpk " data-s="4" src="https://s.tgstc.com/static/web/p.gif" data-e="3" /> <strong class="emj">いしかわ@FSM司祭</strong> <span class="status_name">@u1ro_ishikawa</span> </a> </span> <p class='tweet emj'><span class="f17 c10"><a href="https://x.com/bitter_orange" target="_blank" rel="noreferrer">@bitter_orange</a> ですねえ。脳髄液で適切な濃度まで希釈しといて、カテーテル脳動脈に繋いで定期的なポンプ供給で脳血管に到達したあたりで酵素かなんかでノルアドレナリンに、みたいになれば理想ですが、それでもチューンは相当難しそう……</span></p> <span class='status'> <span class="intent"></span> <span> <a class="link" href="https://x.com/u1ro_ishikawa/status/1901572823011012678" target="_blank" rel="noreferrer">2025-03-17 18:54:25</a> </span> </span> </div> <div class='list_box type_tweet impl_profile' data-index='11' data-id='1901483911831838960'> <span> <a class="user_link" rel="noreferrer" href='https://x.com/dekusuke_horibi' target='_blank'> <img class="lzpk " data-s="8" src="https://s.tgstc.com/static/web/p.gif" data-e="3" /> <strong class="emj">ほりび</strong> <span class="status_name">@dekusuke_horibi</span> </a> </span> <p class='tweet emj'><a href="https://x.com/u1ro_ishikawa" target="_blank" rel="noreferrer">@u1ro_ishikawa</a> （のび太の顔で）寝なくても大丈夫な薬を開発して欲しい（懲りてない）</p> <span class='status'> <span class="intent"></span> <span> <a class="link" href="https://x.com/dekusuke_horibi/status/1901483911831838960" target="_blank" rel="noreferrer">2025-03-17 13:01:07</a> </span> </span> </div> <div class='list_box type_tweet impl_profile' data-index='12' data-id='1901484874143535287'> <span> <a class="user_link" rel="noreferrer" href='https://x.com/u1ro_ishikawa' target='_blank'> <img class="lzpk " data-s="4" src="https://s.tgstc.com/static/web/p.gif" data-e="3" /> <strong class="emj">いしかわ@FSM司祭</strong> <span class="status_name">@u1ro_ishikawa</span> </a> </span> <p class='tweet emj'><span class="f17 c10"><a href="https://x.com/dekusuke_horibi" target="_blank" rel="noreferrer">@dekusuke_horibi</a> 脳脊髄液の還流過程で脳から血流がなくなる＝酸素や栄養分の供給がなくなるので、その間思考とかできなくなりそうだから「寝なくて大丈夫」は厳しそう。目は開いてても思考とかはできない時間になる。効率化できれば睡眠を短時間化したりすることはできるかも【中指でメガネクイってしながら】</span></p> <span class='status'> <span class="intent"></span> <span> <a class="link" href="https://x.com/u1ro_ishikawa/status/1901484874143535287" target="_blank" rel="noreferrer">2025-03-17 13:04:56</a> </span> </span> </div> <div class='list_box type_url type_profile impl_profile_big'> <span> <a class="user_link" href='https://x.com/u1ro_ishikawa' target='_blank' rel="noreferrer"> <img class="lzpk " data-s="9" src="https://s.tgstc.com/static/web/p.gif" data-e="3" /> <strong class="emj">いしかわ@FSM司祭</strong> <span class="status_name">@u1ro_ishikawa</span> </a> <a class="twitter_logo" rel="noreferrer" href="https://x.com/u1ro_ishikawa" target="_blank"><svg class="svg-icon fa-twitter"><use xlink:href="#twitter" /></svg></a> </span> <p class="emj">元学者（PhD）。分子生物学とか。素手で戦ったり鎧で戦ったりする空飛ぶスパゲティモンスター教司祭。パスファインダーRPG日本語版ほんやくチーム、医学・科学系ライター。4thCage の中の人。ほぼ常にクソバカな事しか言わないからブロック推奨。</p> <p><a href="https://t.co/g5ml6232dM" target="_blank" rel="noreferrer">ishikawaya.blogspot.jp</a></p> </div> <div class='list_box type_tweet impl_profile' data-index='14' data-id='1901919503866601565'> <span> <a class="user_link" rel="noreferrer" href='https://x.com/Kyusimunanaya' target='_blank'> <img class="lzpk " data-s="10" src="https://s.tgstc.com/static/web/p.gif" data-e="3" /> <strong class="emj">臼歯虚納屋</strong> <span class="status_name">@Kyusimunanaya</span> </a> </span> <p class='tweet emj'>意外とシンプルだった… そんな単純な仕組みで良いのかと思うけど、単純故にコストパフォーマンスも信頼性も高いんだろうなあ <a href="https://t.co/sWPetMRqqS" target="_blank" rel="noreferrer">x.com/u1ro_ishikawa/…</a></p> <span class='status'> <span class="intent"></span> <span> <a class="link" href="https://x.com/Kyusimunanaya/status/1901919503866601565" target="_blank" rel="noreferrer">2025-03-18 17:52:00</a> </span> </span> </div> <div class='list_box type_tweet impl_profile' data-index='15' data-id='1901881705775997237'> <span> <a class="user_link" rel="noreferrer" href='https://x.com/kuzyofire' target='_blank'> <img class="lzpk " data-s="11" src="https://s.tgstc.com/static/web/p.gif" data-e="3" /> <strong class="emj">セミリタイア九条 🌐📈☀</strong> <span class="status_name">@kuzyofire</span> </a> </span> <p class='tweet emj'>ぼくは不眠症ではないけど、これは衝撃だ <a href="https://t.co/XcrVAoc9yO" target="_blank" rel="noreferrer">x.com/u1ro_ishikawa/…</a></p> <span class='status'> <span class="intent"></span> <span> <a class="link" href="https://x.com/kuzyofire/status/1901881705775997237" target="_blank" rel="noreferrer">2025-03-18 15:21:48</a> </span> </span> </div> <div class='list_box type_tweet impl_profile' data-index='16' data-id='1901876173074026927'> <span> <a class="user_link" rel="noreferrer" href='https://x.com/umewanta' target='_blank'> <img class="lzpk " data-s="12" src="https://s.tgstc.com/static/web/p.gif" data-e="3" /> <strong class="emj">わん太</strong> <span class="status_name">@umewanta</span> </a> </span> <p class='tweet emj'>なんかここだけ読むと「老廃物を洗い流すなにか」ができれば睡眠そのものは棚上げできそうな気がしてきた <a href="https://t.co/cGmCsKL5eT" target="_blank" rel="noreferrer">x.com/u1ro_ishikawa/…</a></p> <span class='status'> <span class="intent"></span> <span> <a class="link" href="https://x.com/umewanta/status/1901876173074026927" target="_blank" rel="noreferrer">2025-03-18 14:59:49</a> </span> </span> </div> <div class='list_box type_tweet impl_profile' data-index='17' data-id='1901664968669634561'> <span> <a class="user_link" rel="noreferrer" href='https://x.com/NM09QSBN' target='_blank'> <img class="lzpk " data-s="13" src="https://s.tgstc.com/static/web/p.gif" data-e="3" /> <strong class="emj">Pontiac Aztek</strong> <span class="status_name">@NM09QSBN</span> </a> </span> <p class='tweet emj'>これを操作できる方法が見つかれば、1週間くらいお泊まりで脳から老廃物を流しまくるクリニックとかやれそう。 <a href="https://t.co/bFKcRfOD20" target="_blank" rel="noreferrer">x.com/u1ro_ishikawa/…</a></p> <span class='status'> <span class="intent"></span> <span> <a class="link" href="https://x.com/NM09QSBN/status/1901664968669634561" target="_blank" rel="noreferrer">2025-03-18 01:00:34</a> </span> </span> </div> <div class='list_box type_tweet impl_profile' data-index='18' data-id='1901939783536132396'> <span> <a class="user_link" rel="noreferrer" href='https://x.com/bgmm225147' target='_blank'> <img class="lzpk " data-s="14" src="https://s.tgstc.com/static/web/p.gif" data-e="3" /> <strong class="emj">bgmm</strong> <span class="status_name">@bgmm225147</span> </a> </span> <p class='tweet emj'>デエビゴ服薬中の我は生き残る事が出来るのか…！？（なお、SASによりC-PAP使用中… よく、つけ忘れるのは御愛嬌） <a href="https://t.co/c83kKxj7tQ" target="_blank" rel="noreferrer">x.com/u1ro_ishikawa/…</a></p> <span class='status'> <span class="intent"></span> <span> <a class="link" href="https://x.com/bgmm225147/status/1901939783536132396" target="_blank" rel="noreferrer">2025-03-18 19:12:35</a> </span> </span> </div> <div class='list_box type_tweet impl_profile' data-index='19' data-id='1901603641263530044'> <span> <a class="user_link" rel="noreferrer" href='https://x.com/xbb1574' target='_blank'> <img class="lzpk " data-s="15" src="https://s.tgstc.com/static/web/p.gif" data-e="3" /> <strong class="emj">xbb</strong> <span class="status_name">@xbb1574</span> </a> </span> <p class='tweet emj'>BZやゾルピデムがなんとなく身体に悪そうという感覚は臨床医なら皆持ってるな。かといって眠れないことを放置もできないジレンマ。オレキシン拮抗薬でこのドレナージシステムが担保もしくは増幅されるならすごい。 <a href="https://t.co/Ltw6qsJwPs" target="_blank" rel="noreferrer">x.com/u1ro_ishikawa/…</a></p> <span class='status'> <span class="intent"></span> <span> <a class="link" href="https://x.com/xbb1574/status/1901603641263530044" target="_blank" rel="noreferrer">2025-03-17 20:56:52</a> </span> </span> </div> <div class='list_box type_tweet impl_profile' data-index='20' data-id='1901752508919480406'> <span> <a class="user_link" rel="noreferrer" href='https://x.com/Twittarou3' target='_blank'> <img class="lzpk " data-s="16" src="https://s.tgstc.com/static/web/p.gif" data-e="3" /> <strong class="emj">kouji</strong> <span class="status_name">@Twittarou3</span> </a> </span> <p class='tweet emj'>ゾルピデムを飲み続けたら、今度はゾルピデムを飲まないと眠れなくなるようになるから、困ったことになるんだよね。ゾルピデムが老廃物を洗い流すのを抑えた分の時間、余計に睡眠時間をとるとかすることで何とか認知症の予防とかできないのだろうか？ <a href="https://t.co/9PCAkwxHLh" target="_blank" rel="noreferrer">x.com/NatGeoMagJP/st…</a></p> <span class='status'> <span class="intent"></span> <span> <a class="link" href="https://x.com/Twittarou3/status/1901752508919480406" target="_blank" rel="noreferrer">2025-03-18 06:48:25</a> </span> </span> </div> <div class='list_box type_tweet impl_profile' data-index='21' data-id='1901925017803530322'> <span> <a class="user_link" rel="noreferrer" href='https://x.com/hiroemon432' target='_blank'> <img class="lzpk " data-s="17" src="https://s.tgstc.com/static/web/p.gif" data-e="3" /> <strong class="emj">ヒロえもん432</strong> <span class="status_name">@hiroemon432</span> </a> </span> <p class='tweet emj'>元記事読んだマイスリーの話だったけど、BZやオレキシン系はどうなんだろう？ <a href="https://t.co/arAF8kcvkV" target="_blank" rel="noreferrer">x.com/NatGeoMagJP/st…</a></p> <span class='status'> <span class="intent"></span> <span> <a class="link" href="https://x.com/hiroemon432/status/1901925017803530322" target="_blank" rel="noreferrer">2025-03-18 18:13:54</a> </span> </span> </div> <div class='list_box type_tweet impl_profile' data-index='22' data-id='1901930855226020344'> <span> <a class="user_link" rel="noreferrer" href='https://x.com/gyohny' target='_blank'> <img class="lzpk " data-s="18" src="https://s.tgstc.com/static/web/p.gif" data-e="3" /> <strong class="emj">ぎょにー</strong> <span class="status_name">@gyohny</span> </a> </span> <p class='tweet emj'>ちなみにこの実験は睡眠障害を訴えた時に最も出されやすい「マイスリー(ゾルピデム)」のみ使用してて、睡眠薬にはすごくたくさんの種類があります →ロゼレム(メラトニン) →デエビゴ・ベルソムラ(覚醒物質抑える系) →中間型のベンゾ系 →短期方のベンゾ系の順で耐性がつきにくいんじゃないかな？ <a href="https://t.co/vKK63QQLUn" target="_blank" rel="noreferrer">x.com/natgeomagjp/st…</a></p> <span class='status'> <span class="intent"></span> <span> <a class="link" href="https://x.com/gyohny/status/1901930855226020344" target="_blank" rel="noreferrer">2025-03-18 18:37:06</a> </span> </span> </div> <div class='list_box type_tweet impl_profile' data-index='23' data-id='1901877060475486581'> <span> <a class="user_link" rel="noreferrer" href='https://x.com/coffee_caraway' target='_blank'> <img class="lzpk " data-s="19" src="https://s.tgstc.com/static/web/p.gif" data-e="3" /> <strong class="emj">読書会@coffee caraway</strong> <span class="status_name">@coffee_caraway</span> </a> </span> <p class='tweet emj'>身内が睡眠薬に依存していて晩年様子がおかしかったのを思い出す。ただの老化と違うと感じてた。同じ薬でなくても覚醒を妨げる弊害はあり得ると思う。症状を押さえ込むと、違う形で表れる。それは身体が部品を集めた機械ではなく全体でひとつの機関だからだ。木だけを見ていれば、森は枯れる。 <a href="https://t.co/scSeWGw2L6" target="_blank" rel="noreferrer">x.com/natgeomagjp/st…</a></p> <span class='status'> <span class="intent"></span> <span> <a class="link" href="https://x.com/coffee_caraway/status/1901877060475486581" target="_blank" rel="noreferrer">2025-03-18 15:03:21</a> </span> </span> </div> <div class='list_box type_tweet impl_profile' data-index='24' data-id='1901584008968106089'> <span> <a class="user_link" rel="noreferrer" href='https://x.com/pu_rari' target='_blank'> <img class="lzpk " data-s="20" src="https://s.tgstc.com/static/web/p.gif" data-e="3" /> <strong class="emj">ぷらり</strong> <span class="status_name">@pu_rari</span> </a> </span> <p class='tweet emj'>言われてみると、親戚の年寄りの中で痴呆の騒ぎしているのは中年くらいから睡眠薬飲んでいた叔母だけだな…直接関係あるかはわからないけど、やや納得できる。 <a href="https://t.co/L1dbOzawFr" target="_blank" rel="noreferrer">x.com/natgeomagjp/st…</a></p> <span class='status'> <span class="intent"></span> <span> <a class="link" href="https://x.com/pu_rari/status/1901584008968106089" target="_blank" rel="noreferrer">2025-03-17 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睡眠時に脳内の老廃物を洗い流すシステム、研究によってかなりわかってきていた→睡眠薬がその「脳の掃除」を妨げているおそれも - Togetter [トゥギャッター]