Singulair: Uses, Drug Interactions, & Warnings

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It’s also used to prevent asthma symptoms during exercise and to relieve hay fever (allergies). </p> </div> </div> <div class="c-hero__aside"> </div> </div> </div> </div> <div class="c-attribution-sidebar c-attribution--hero"> <ul class="c-attribution-sidebar__list"> <li class="c-attribution-sidebar__item c-attribution-sidebar__item--author"> <div class="c-attribution__primary"> <div class="c-attribution-sidebar__name"> <span class="c-attribution-sidebar__before">Written By</span> <div class="c-profile-block"> <div class="c-profile-block__content"> <a href="https://www.drugwatch.com/authors/mllamas/" class="c-profile-block__name">Michelle Llamas, BCPA</a> </div> </div> </div> </div> </li> <li class="c-attribution-sidebar__item c-attribution-sidebar__item--editor"> <span class="c-attribution-sidebar__before">Edited By</span> <span class="c-attribution-sidebar__name"> <a class="c-attribution-sidebar__link" href="https://www.drugwatch.com/authors/sophia-clifton/">Sophia Clifton</a> </span> </li> <li class="c-attribution-sidebar__item c-attribution-sidebar__item--reviewer"> <span class="c-attribution-sidebar__before">Medically Reviewed by</span> <span class="c-attribution-sidebar__name"> <a class="c-attribution-sidebar__link" href="https://www.drugwatch.com/contributors/kenneth-s-fill/">Kenneth S. Fill, Pharm.D., MBA</a> </span> </li> <li class="c-attribution-sidebar__sources"> <span class="c-attribution-sidebar__before">This page features</span> <a class="c-attribution-sidebar__link js-scrollTo" href="#sources">5 Cited Research Articles</a> </li> </span> </li> </ul> <div class="c-modified"> <strong class="c-modified__title">Last Modified:</strong> March 13, 2025 </div> <a href="#fact-check-modal" class="c-button c-button--outline c-button--xs c-sidebar-attribution__checked js-modalLightbox js-trackClicks tooltipstered"><i class="o-icon o-icon--check c-button__icon c-button__icon--before"></i> <span class="c-button__span">Fact Checked</span></a>  <div id="fact-check-modal" class="eat__modal mfp-hide" data-location="modal"> <strong class="eat__title">Medically Reviewed</strong> <div class="eat__divider"> <span class="eat__divider-icon o-icon o-icon--check"></span> </div> <div class="eat__content"> <p>Board-certified physicians medically review Drugwatch.com content to ensure its accuracy and quality.</p> <p>Drugwatch.com partners with Physicians’ Review Network Inc. to enlist specialists. PRN is a nationally recognized leader in providing independent medical reviews.</p> <p>Reviewer specialties include internal medicine, gastroenterology, oncology, orthopedic surgery and psychiatry.</p> </div> </div> <a href="#why-trust-modal" class="c-button c-button--primary c-button--xs c-sidebar-attribution__checked js-modalLightbox js-trackClicks tooltipstered"><span class="c-button__span">Why Trust DrugWatch?</span></a> <div id="why-trust-modal" class="eat__modal why-trust__modal f mfp-hide" data-location="modal"> <div class="eat__title"> <h2 class="h2">Drugwatch.com has been <span class="eat__span">empowering patients</span> for more than a decade</h2> </div> <div class="eat__content"> <p>Drugwatch.com has provided reliable, trusted information about medications, medical devices and general health since 2008. We’ve also connected thousands of people injured by drugs and medical devices with top-ranked national law firms to take action against negligent corporations. <p>Our team includes experienced medical writers, award-winning journalists, researchers and certified medical and legal experts. Drugwatch.com is HONCode (Health On the Net Foundation) certified. This means the high-quality information we provide comes from credible sources, such as peer-reviewed medical journals and expert interviews.</p> <p>The information on Drugwatch.com has been medically and legally reviewed by more than 30 expert contributors, including doctors, pharmacists, lawyers, patient advocates and other health care professionals. Our writers are members of professional associations, including American Medical Writers Association, American Bar Association, The Alliance of Professional Health Advocates and International Society for Medical Publication Professionals.</p> <h2 class="h2 why-trust__title">About Drugwatch.com</h2> <div class="c-list c-list--"> <div class="c-list__content"> <ul class="c-ul"> <li class="c-ul__item">Assisting patients and their families since 2008.</li> <li class="c-ul__item">Helped more than 12,000 people find legal help.</li> <li class="c-ul__item">A+ rating from the Better Business Bureau.</li> <li class="c-ul__item">5-star reviewed medical and legal information site.</li> </ul> </div> </div> <a href="https://www.drugwatch.com/about/" class="c-button c-button--outline js-trackClicks"><span class="c-button__span">Learn More About Us</span></a> <h2 class="h2 why-trust__title">Testimonials</h2> <blockquote class="c-blockquote c-blockquote--left c-blockquote--small"> <div class="c-blockquote__content"> <div class="c-blockquote__quote">"Drugwatch opened my eyes to the realities of big pharmacy. Having a family member with major depression and anxiety, I was looking for information on her medications. I found information that was very helpful, that her psychiatrist never told her."</div> <footer class="c-blockquote__footer"> <strong class="c-blockquote__title">Marianne Zahren</strong> <span class="c-blockquote__subtitle">Patient’s Family Member</span> </footer> </div> </blockquote> <div class="c-action-list"> <ul class="c-action-list__items"> <li class="c-action-list__item c-action-list__section-head"> <div class="c-action-block"> <div class="c-action-block__media"> <div class="c-action-block__image"> <picture class="c-picture"> <source srcset="https://www.drugwatch.com/wp-content/uploads/google-review-250x0-c-default.webp" type="image/webp"> <img loading="lazy" src="https://www.drugwatch.com/wp-content/uploads/google-review-250x0-c-default.jpg" alt="Google Business Rating" class="o-image" width="250" height="131" /> </picture> </div> </div> <div class="c-action-block__content"> </div> </div> </li> <li class="c-action-list__item c-action-list__section-head"> <div class="c-action-block"> <div class="c-action-block__media"> <div class="c-action-block__image"> <picture class="c-picture"> <source srcset="https://www.drugwatch.com/wp-content/uploads/bbb_logo-210x0-c-default.webp" type="image/webp"> <img loading="lazy" src="https://www.drugwatch.com/wp-content/uploads/bbb_logo-210x0-c-default.jpg" alt="BBB A+ Rating Logo" class="o-image" width="210" height="102" /> </picture> </div> </div> <div class="c-action-block__content"> </div> </div> </li> </ul> </div> </div> </div> </div> <div class="c-content-builder"> <div class="c-wysiwyg"> <p>Merck Sharp & Dohme Corp., a subsidiary of <a href="/manufacturers/merck/">Merck & Co. Inc.</a>, markets Singulair in the United States. The U.S. Food and Drug Administration originally approved the drug in 1998. It’s sold under its brand name and in generic form.</p> <p>“While Singulair is not a steroid and is not typically considered an immunosuppressant, it nevertheless does interfere with immune pathways by limiting the production of leukotrienes, chemicals in the body that are part of the ‘inflammatory cascade,’” Dr. Caleb Alexander, a professor at Johns Hopkins Bloomberg School of Public Health and co-director of the Center for Drug Safety and Effectiveness, told Drugwatch.</p> <p>The body releases leukotrienes after coming in contact with an allergen. The chemicals cause tightening of the airway muscles and produce fluid and mucus. Singulair blocks these chemicals to help control asthma and allergy symptoms.</p> <p>Singulair isn’t for sudden asthma attacks. Patients should follow instructions from their health care provider for treating asthma attacks, such as using an inhaler.</p> </div> <h2 class="h2" id="how-to-take-singulair">How to Take Singulair</h2> <div class="c-wysiwyg"> <p>Singulair is available in 10 mg tablets, 5 mg and 4 mg chewable tablets and 4 mg oral granules. This medicine can be used in people 12 months or older for asthma, and the dosage varies by age.</p> <p>The FDA also <a href="/fda/approval-process/">approved</a> it to treat exercise-induced asthma in people 6 years and older and allergic rhinitis in people 2 years and older, also called hay fever.</p> <p>People can take this medication with or without food. If you miss a dose, don’t take two doses at the same time — wait until your next scheduled dose.</p> <h3>Asthma</h3> <p>The recommended dose varies from 4 mg to 10 mg depending on age and may include tablets, chewable tablets and granules.</p> <p>The drug’s label recommends taking the drug at night because the drug wasn’t tested in the morning during <a href="/fda/clinical-trials/">clinical trials</a>, but the medication guide instructs people to take their medicine as prescribed by their medical providers.</p> <p>“Sometimes we dose Singulair at night because many people have worse asthma symptoms at night than during the day,” Alexander said. “However, many people take Singulair during the morning rather than evening, and what works for one person may not work for another. In other words, there is no one-size-fits-all approach, and it’s more important to take it regularly than it is to take it at a certain hour of the day.”</p> </div> <div class="c-related-posts c-related-posts--horizontal c-related-posts--single"> <ul class="c-related-posts__list"> <li class="c-related-posts__item "> <article class="c-post-block c-post-block--card c-post-block--horizontal"> <div class="c-post-block__inner u-hover-children"> <div class="c-post-block__image-wrapper"> <picture class="c-picture"> <source srcset="https://www.drugwatch.com/wp-content/uploads/best-and-worst-cities-for-asthma-featured-480x320-c-default.webp" type="image/webp"> <img loading="lazy" src="https://www.drugwatch.com/wp-content/uploads/best-and-worst-cities-for-asthma-featured-480x320-c-default.jpg" alt="Woman using an inhaler outdoors." class="o-image c-post-block__image" width="480" height="320" /> </picture> </div> <div class="c-post-block__content"> <div class="c-post-block__before"> <strong class="strong c-related-posts__title">Related Content</strong> </div> <a href="https://www.drugwatch.com/singulair/survey-asthma-cities/" class="c-post-block__link"> <span class="c-post-block__title">Best (And Worst) Cities for Asthma</span> </a> <div class="c-profile-block c-post-block__meta"> <div class="c-profile-block__content"> <span class="c-profile-block__name"></span> <span class="c-profile-block__after">April 14, 2023</span> </div> </div> </div> </div> </article> </li> </ul> </div> <div class="c-wysiwyg"> <h3>Preventing Exercise-Induced Bronchoconstriction</h3> <p>In addition to treating asthma, Singulair can help people with breathing problems brought on by exercise. People should take the drug at least two hours before exercise, according to the drug’s label.</p> <p>People 15 years of age and older take one 10 mg tablet. Children six to 14 years of age take one 5 mg chewable tablet.</p> <p>Don’t take another dose within 24 hours of the previous dose. If you are already taking Singulair for asthma, don’t take an additional dose before exercise.</p> <h3>Allergic Rhinitis (Hay Fever)</h3> <p>People treating allergies should take Singulair once daily in the morning or evening. In clinical trials, the drug worked just as well regardless of the time of day or if taken with or without food.</p> <p>The drug can also be taken as needed for perennial allergies as recommended by a medical provider.</p> </div> <div class="c-list c-list--card c-list--ul"> <strong class="c-list__title"> Recommended doses: </strong> <div class="c-list__content"> <ul class="c-ul c-ul--card"> <li class="c-ul__item">Adults and adolescents 15 years of age and older, one 10-mg tablet</li> <li class="c-ul__item"> Children six to 14 years of age, one 5-mg chewable tablet</li> <li class="c-ul__item"> Children two to five years of age, one 4-mg chewable tablet or one packet of 4-mg oral granules</li> </ul> </div> </div> <h2 class="h2" id="side-effects">Side Effects</h2> <div class="c-wysiwyg"> <p>Most side effects associated with Singulair are mild. In general, the medication is well tolerated in people taking it for asthma or allergies, according to Alexander.</p> <p>“Of course, all medicines have risks, and most medicines have rare but serious risks. In the case of Singulair, the most common adverse effects include upper respiratory infections, fevers, headaches and sore throat,” he said. “Of course, it is often difficult to know for sure whether these types of symptoms represent an adverse drug reaction or some other process.”</p> <p>Singulair was tested in 2,950 adult and adolescent patients, and 1,955 people received the drug. In 2022 clinical trials, the most common side effects occurred in 5% or more of people who took Singulair.</p> </div> <div class="c-list c-list--card c-list--ul"> <strong class="c-list__title"> Side effects with an incidence of 5% or more and greater than placebo in clinical trials include: </strong> <div class="c-list__content"> <ul class="c-ul c-ul--card"> <li class="c-ul__item">Upper respiratory infection</li> <li class="c-ul__item"> Fever</li> <li class="c-ul__item"> Headache</li> <li class="c-ul__item"> Pharyngitis (sore throat)</li> <li class="c-ul__item"> Cough</li> <li class="c-ul__item"> Abdominal pain</li> <li class="c-ul__item"> Diarrhea</li> <li class="c-ul__item"> Otitis media (ear inflammation or infection)</li> <li class="c-ul__item"> Influenza (flu)</li> <li class="c-ul__item"> Rhinorrhea (runny nose)</li> <li class="c-ul__item"> Sinusitis (sinus infection)</li> </ul> </div> </div> <div class="c-wysiwyg"> <p>Other minor, less common side effects include body pain, fatigue, fever, indigestion, dizziness, rash and abnormal liver enzymes.</p> <p>If you experience side effects, please inform your medical provider.</p> </div> <h2 class="h2" id="drug-interactions">Drug Interactions</h2> <div class="c-wysiwyg"> <p>Singulair may interact with other substances. Make sure to tell your medical provider about all medications, supplements, herbs or vitamins you are taking.</p> <p>The prescription information doesn’t list any specific drug interactions, but it recommends that people with aspirin sensitivity avoid aspirin or other nonsteroidal anti-inflammatory drugs while taking Singulair.</p> </div> <div class="c-factbox c-factbox--card"> <div class="c-factbox__title">LAWSUIT INFORMATION</div> <div class="c-factbox__copy">People who were diagnosed with a mental health disorder after taking Singulair are filing lawsuits against the drug's manufacturer.</div> <a href="https://www.drugwatch.com/singulair/lawsuits/" class="c-button js-trackClicks c-button c-button--soft-sell"><span class="c-button__span">View Lawsuits</span></a> </div> <h2 class="h2" id="black-box-warning">Black Box Warning for Serious Neuropsychiatric Events</h2> <div class="c-wysiwyg"> <p>In March 2020, the FDA required Merck to place a <a href="/fda/black-box-warnings/">black box warning</a> — the agency’s most prominent warning — on Singulair drug labels warning about the risk of serious mental health problems, also called neuropsychiatric events. These include: agitation, aggression, depression, sleep disturbances, suicidal thoughts and behavior (including suicide).</p> <p>“We recognize that millions of Americans suffer from asthma or allergies and rely on medication to treat these conditions. The incidence of neuropsychiatric events associated with montelukast is unknown, but some reports are serious, and many patients and health care professionals are not fully aware of these risks,” Dr. Sally Seymour, director of the Division of Pulmonary, Allergy and Rheumatology Products in the FDA’s Center for Drug Evaluation and Research, said in a <a href="https://www.fda.gov/news-events/press-announcements/fda-requires-stronger-warning-about-risk-neuropsychiatric-events-associated-asthma-and-allergy" target="_blank" rel="noopener">statement</a>.</p> <p>The benefits of Singulair might not outweigh the risks in some people with allergic rhinitis. The FDA recommends the drug only be used in people who don’t respond to or cannot use other allergy treatments. Talk about the risks and benefits of this medication with your medical provider.</p> <p>Mental health symptoms may occur in people with or without a history of mental health issues, according to the drug’s <a href="https://www.organon.com/product/usa/pi_circulars/s/singulair/singulair_mg.pdf" target="_blank" rel="noopener">medication guide</a>. Notify your medical provider right away if you experience changes in thoughts or behavior. Discuss Singulair alternatives that might be the right option for you.</p> </div> <div class="c-list c-list--card c-list--split c-list--ul"> <strong class="c-list__title"> Unusual thinking or behavior may include: </strong> <div class="c-list__content"> <ul class="c-ul c-ul--card c-ul--split"> <li class="c-ul__item">Agitation, including aggressive behavior or hostility</li> <li class="c-ul__item"> Attention problems </li> <li class="c-ul__item"> Bad or vivid dreams </li> <li class="c-ul__item"> Depression </li> <li class="c-ul__item"> Disorientation (confusion) </li> <li class="c-ul__item"> Feeling anxious </li> <li class="c-ul__item"> Hallucinations (seeing or hearing things that are not really there)</li> <li class="c-ul__item"> Irritability </li> <li class="c-ul__item"> Memory problems</li> <li class="c-ul__item"> Obsessive-compulsive symptoms </li> <li class="c-ul__item"> Restlessness </li> <li class="c-ul__item"> Sleep walking </li> <li class="c-ul__item"> Stuttering </li> <li class="c-ul__item"> Suicidal thoughts and actions (including suicide) </li> <li class="c-ul__item"> Tremor </li> <li class="c-ul__item"> Trouble sleeping</li> <li class="c-ul__item"> Uncontrolled muscle movements</li> </ul> </div> </div> <h2 class="h2" id="litigation-over-side-effects">Litigation over Side Effects</h2> <div class="c-wysiwyg"> <p>After the FDA placed the <a href="/singulair/black-box-warning/">black box warning on the drug</a>, some people filed <a href="/singulair/lawsuits/">Singulair lawsuits</a> against Merck claiming the drugmaker failed to warn about the risk of suicidal thoughts and other neuropsychiatric problems.</p> <p>One plaintiff from Wisconsin filed a lawsuit on behalf or her child in September 2020. According to her complaint, Merck ignored studies that showed Singulair could cause neuropsychiatric events.</p> <p>After taking Singulair, her child was admitted to a psychiatric center and was diagnosed with “major depressive disorder, anxiety disorder, obsessive-compulsive disorder, ego-dystonic and intrusive thoughts about homicidal, suicidal, and sexual thoughts, and poor coping.”</p> <p>“Originally, the Singulair label contained no warnings regarding neuropsychiatric events. Over the past 22 years Defendant has slowly and belatedly added grossly insufficient warnings regarding neuropsychiatric events to the product label,” her lawsuit claimed.</p> <p>Merck hasn’t issued a statement about the lawsuits.</p> </div> </div> <div class="c-content__after"> <div class="c-kb-toggle hide-desktop"> <a class="c-kb-toggle__link js-modalLightbox c-button c-button--kb-toggle js-trackClicks" href="#c-knowledge-box"> <div class="c-kb-toggle__image"> <picture class="c-picture"> <source srcset="https://www.drugwatch.com/wp-content/uploads/singulair-pill-copy-96x50-c-default.webp" type="image/webp"> <img loading="lazy" src="https://www.drugwatch.com/wp-content/uploads/singulair-pill-copy-96x50-c-default.jpg" alt="Singulair" class="o-image" width="96" height="50" /> </picture> </div> <div class="c-kb-toggle__copy"> <strong class="c-kb-toggle__title">Singulair Facts</strong> <span class="c-kb-toggle__icon o-icon o-icon--external"></span> </div> </a> </div> <div class="c-disclaimer c-disclaimer--global"> <i class="o-icon o-icon--warning-fill"></i> Please seek the advice of a medical professional before making health care decisions. </div> <div class="c-share"> <strong class="strong c-share__heading">Share This Page:</strong> <ul class="c-share__list"> <li class="c-share__item"> <a href="https://twitter.com/intent/tweet?original_referer=https://www.drugwatch.com/singulair/&text=Singulair&url=https://www.drugwatch.com/singulair/" class="c-button c-button--s c-button--twitter c-share__link" title="Share this page on Twitter" target="_blank" rel="noopener noreferrer" onclick="javascript:window.open(this.href,'', 'menubar=no,toolbar=no,resizable=yes,scrollbars=yes,height=600,width=600');return false;"><span class="c-button__span"></span><i class="o-icon o-icon--twitter c-button__icon c-button__icon--after"><span class="u-sr-only">Share this page on Twitter</span></i> </a> </li> <li class="c-share__item"> <a href="https://www.facebook.com/sharer/sharer.php?app_id=309437425817038&sdk=joey&u=https://www.drugwatch.com/singulair/&display=popup&ref=plugin" class="c-button c-button--s c-button--facebook c-share__link" title="Share this page on Facebook" target="_blank" rel="noopener noreferrer" onclick="javascript:window.open(this.href,'', 'menubar=no,toolbar=no,resizable=yes,scrollbars=yes,height=600,width=600');return false;"><span class="c-button__span"></span><i class="o-icon o-icon--facebook c-button__icon c-button__icon--after"><span class="u-sr-only">Share this page on Facebook</span></i> </a> </li> <li class="c-share__item"> <button class="c-button c-button--s c-button--primary c-share__link js-slideToggle" title="Copy Link" data-target="#share-link"><span class="c-button__span"></span><i class="o-icon o-icon--link c-button__icon c-button__icon--after"><span class="u-sr-only">Copy Link</span></i> </button> </li> </ul> <div id="share-link" class="c-share__copy"> <label for="copy-link">Share This Page:</label> <textarea id="copy-link" name="copy-link">https://www.drugwatch.com/singulair/</textarea> <button class="c-button c-button--s c-button--primary js-copyLink"><span class="c-button__span">Copy Link</span></button> </div> </div> <div class="feedback-widget "> <div class="l-container review-form-container"> <ul class="review-step-indicator"> <li class="review-step-indicator__item is-active" data-step="intro"> </li> <li class="review-step-indicator__item" data-step="answer"> </li> <li class="review-step-indicator__item" data-step="form"> </li> </ul> <div class="c-form__step is-active" data-step="intro"> <span class="feedback-widget__preface">TELL US WHAT YOU THINK</span> <h3 class="feedback-widget__title">Did You Find Drugwatch Helpful?</h3> <div class="row"> <a href="" class="c-button c-button--primary c-button--outline c-button--feedback js-reviewYes"><span class="c-button__span">Yes</span></a> <a href="" class="c-button c-button--primary c-button--outline c-button--feedback js-reviewNo"><span class="c-button__span">No</span></a> </div> </div> <div class="c-form__step" data-step="yes"> <h3 class="feedback-widget__title">Thank you for your feedback. 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One of our content team members will be in touch with you soon.</p></div> </div> </div> </div> </div> </main> <aside class="c-page__aside" data-location="page-sidebar"> <div class="c-attribution-sidebar hide-mobile"> <ul class="c-attribution-sidebar__list"> <li class="c-attribution-sidebar__item c-attribution-sidebar__item--author"> <div class="c-attribution__primary"> <div class="c-attribution-sidebar__name"> <span class="c-attribution-sidebar__before">Written By</span> <div class="c-profile-block"> <div class="c-profile-block__content"> <a href="https://www.drugwatch.com/authors/mllamas/" class="c-profile-block__name">Michelle Llamas, BCPA</a> </div> </div> </div> </div> </li> <li class="c-attribution-sidebar__item c-attribution-sidebar__item--editor"> <span class="c-attribution-sidebar__before">Edited By</span> <span class="c-attribution-sidebar__name"> <a class="c-attribution-sidebar__link" href="https://www.drugwatch.com/authors/sophia-clifton/">Sophia Clifton</a> </span> </li> <li class="c-attribution-sidebar__item c-attribution-sidebar__item--reviewer"> <span class="c-attribution-sidebar__before">Medically Reviewed by</span> <span class="c-attribution-sidebar__name"> <a class="c-attribution-sidebar__link" href="https://www.drugwatch.com/contributors/kenneth-s-fill/">Kenneth S. 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Our writers are members of professional associations, including American Medical Writers Association, American Bar Association, The Alliance of Professional Health Advocates and International Society for Medical Publication Professionals.</p> <h2 class="h2 why-trust__title">About Drugwatch.com</h2> <div class="c-list c-list--"> <div class="c-list__content"> <ul class="c-ul"> <li class="c-ul__item">Assisting patients and their families since 2008.</li> <li class="c-ul__item">Helped more than 12,000 people find legal help.</li> <li class="c-ul__item">A+ rating from the Better Business Bureau.</li> <li class="c-ul__item">5-star reviewed medical and legal information site.</li> </ul> </div> </div> <a href="https://www.drugwatch.com/about/" class="c-button c-button--outline js-trackClicks"><span class="c-button__span">Learn More About Us</span></a> <h2 class="h2 why-trust__title">Testimonials</h2> <blockquote class="c-blockquote c-blockquote--left c-blockquote--small"> <div class="c-blockquote__content"> <div class="c-blockquote__quote">"Drugwatch opened my eyes to the realities of big pharmacy. Having a family member with major depression and anxiety, I was looking for information on her medications. I found information that was very helpful, that her psychiatrist never told her."</div> <footer class="c-blockquote__footer"> <strong class="c-blockquote__title">Marianne Zahren</strong> <span class="c-blockquote__subtitle">Patient’s Family Member</span> </footer> </div> </blockquote> <div class="c-action-list"> <ul class="c-action-list__items"> <li class="c-action-list__item c-action-list__section-head"> <div class="c-action-block"> <div class="c-action-block__media"> <div class="c-action-block__image"> <picture class="c-picture"> <source srcset="https://www.drugwatch.com/wp-content/uploads/google-review-250x0-c-default.webp" type="image/webp"> <img loading="lazy" src="https://www.drugwatch.com/wp-content/uploads/google-review-250x0-c-default.jpg" alt="Google Business Rating" class="o-image" width="250" height="131" /> </picture> </div> </div> <div class="c-action-block__content"> </div> </div> </li> <li class="c-action-list__item c-action-list__section-head"> <div class="c-action-block"> <div class="c-action-block__media"> <div class="c-action-block__image"> <picture class="c-picture"> <source srcset="https://www.drugwatch.com/wp-content/uploads/bbb_logo-210x0-c-default.webp" type="image/webp"> <img loading="lazy" src="https://www.drugwatch.com/wp-content/uploads/bbb_logo-210x0-c-default.jpg" alt="BBB A+ Rating Logo" class="o-image" width="210" height="102" /> </picture> </div> </div> <div class="c-action-block__content"> </div> </div> </li> </ul> </div> </div> </div> </div> <div class="c-jump-to c-jump-to-- hide-mobile" data-location="jump-to"> <strong class="strong c-jump-to__title">On This Page</strong> <ul class="c-jump-to__list"> <li class="c-jump-to__item"> <a class="c-jump-to__link js-scrollTo js-trackClicks" href="#how-to-take-singulair">How to Take Singulair</a> </li> <li class="c-jump-to__item"> <a class="c-jump-to__link js-scrollTo js-trackClicks" href="#side-effects">Side Effects</a> </li> <li class="c-jump-to__item"> <a 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class="c-knowledge-box__column-item"> <strong class="c-knowledge-box__column-item-title">Used to Treat:</strong> <span class="c-knowledge-box__column-item-copy">Asthma, allergies and prevention of airways narrowing during exercise</span> </li> <li class="c-knowledge-box__column-item"> <strong class="c-knowledge-box__column-item-title">Manufacturer</strong> <span class="c-knowledge-box__column-item-copy">Merck Sharp & Dohme Corp.</span> </li> <li class="c-knowledge-box__column-item"> <strong class="c-knowledge-box__column-item-title">Common Side Effects:</strong> <span class="c-knowledge-box__column-item-copy">Upper respiratory infection, fever, headache, pharyngitis, cough, abdominal pain, diarrhea, otitis media, influenza, rhinorrhea, sinusitis, otitis</span> </li> <li class="c-knowledge-box__column-item"> <strong class="c-knowledge-box__column-item-title">Black Box Warning</strong> <span class="c-knowledge-box__column-item-copy">Neuropsychiatric events</span> </li> </ol> </div> </div> <div class="c-related-menu"> <strong class="menu__title">Recommended Reading</strong> <ul class="menu__list"> <li class="menu__item"> <a class="menu__link" href="https://www.drugwatch.com/manufacturers/merck/">Merck & Co.</a> </li> <li class="menu__item"> <a class="menu__link" href="https://www.drugwatch.com/health/children/">Children’s Comprehensive Health Guide</a> </li> <li class="menu__item"> <a class="menu__link" href="https://www.drugwatch.com/vioxx/">Vioxx</a> </li> <li class="menu__item"> <a class="menu__link" href="https://www.drugwatch.com/vioxx/lawsuits/">Vioxx Lawsuits</a> </li> <li class="menu__item"> <a class="menu__link" href="https://www.drugwatch.com/singulair/lawsuits/">Singulair Lawsuits</a> </li> <li class="menu__item"> <a class="menu__link" href="https://www.drugwatch.com/nuvasive-magec/">NuVasive MAGEC System</a> </li> </ul> </div> </aside> </div> </div> <footer class="c-page__footer" data-location="page-footer"> <div class="l-container"> <div class="c-footer-nav l-row"> <div class="c-footer-nav__main c-footer-nav__main-hasrelatedPosts"> <div class="c-related-menu"> <strong class="menu__title">Recommended Reading</strong> <ul class="menu__list"> <li class="menu__item"> <a class="menu__link" href="https://www.drugwatch.com/manufacturers/merck/">Merck & Co.</a> </li> <li class="menu__item"> <a class="menu__link" href="https://www.drugwatch.com/health/children/">Children’s Comprehensive Health Guide</a> </li> <li class="menu__item"> <a class="menu__link" href="https://www.drugwatch.com/vioxx/">Vioxx</a> </li> <li class="menu__item"> <a class="menu__link" href="https://www.drugwatch.com/vioxx/lawsuits/">Vioxx Lawsuits</a> </li> <li class="menu__item"> <a class="menu__link" href="https://www.drugwatch.com/singulair/lawsuits/">Singulair Lawsuits</a> </li> <li class="menu__item"> <a class="menu__link" href="https://www.drugwatch.com/nuvasive-magec/">NuVasive MAGEC System</a> </li> </ul> </div> </div> </div> <div class="c-footer-attribution l-row"> <div class="c-footer-attribution__item c-footer-attribution__item--author c-footer-attribution__main"> <div class="c-footer-attribution__header"> <picture class="c-picture"> <source srcset="https://www.drugwatch.com/wp-content/uploads/michelle-llamas-80x80-c-default.webp" type="image/webp"> <img loading="lazy" src="https://www.drugwatch.com/wp-content/uploads/michelle-llamas-80x80-c-default.jpg" alt="Michelle Llamas, Senior Content Writer" class="o-image c-footer-attribution__img" width="80" height="80" /> </picture> <div class="c-footer-attribution__info"> <span class="c-footer-attribution__before">Written By</span> <span class="c-footer-attribution__name"> <a class="c-footer-attribution__link" href="https://www.drugwatch.com/authors/mllamas/">Michelle Llamas, BCPA</a> </span> <span class="c-footer-attribution__after">Board Certified Patient Advocate</span> </div> <ul class="c-footer-attribution__contact"> <li class="c-footer-attribution__contact-item"> <a href="mailto:mllamas@drugwatch.com" aria-label="Email" class="c-button c-footer-attribution__contact-link c-footer-attribution__contact-link--email"> <span class="c-footer-attribution__contact-icon o-icon o-icon--email"></span> <span class="c-footer-attribution__contact-copy">Email</span> </a> </li> </ul> </div> <p class="c-footer-attribution__preview">Michelle Llamas has been writing articles and producing podcasts about drugs, medical devices and the FDA for nearly a decade. She focuses on various medical conditions, health policy, COVID-19, LGBTQ health, mental health and women’s health issues. Michelle collaborates with experts, including board-certified doctors, patients and advocates, to provide trusted health information to the public. Some of her qualifications include:</p> <ul class="c-footer-attribution__highlights"> <li class="c-footer-attribution__highlights-item"> <span class="c-footer-attribution__highlights-icon o-icon o-icon--shield"></span> Member of American Medical Writers Association (AMWA) and former Engage Committee and Membership Committee member</li> <li class="c-footer-attribution__highlights-item"> <span class="c-footer-attribution__highlights-icon o-icon o-icon--shield"></span> Centers for Disease Control and Prevention (CDC) Health Literacy certificates</li> <li class="c-footer-attribution__highlights-item"> <span class="c-footer-attribution__highlights-icon o-icon o-icon--shield"></span> Original works published or cited in The Lancet, British Journal of Clinical Pharmacology and the Journal for Palliative Medicine</li> <li class="c-footer-attribution__highlights-item"> <span class="c-footer-attribution__highlights-icon o-icon o-icon--shield"></span> Board Certified Patient Advocate, Patient Advocacy Certificate from University of Miami</li> </ul> </div> <div class="c-footer-attribution__aside"> <div class="c-footer-attribution__item c-footer-attribution__item--editor"> <span class="c-footer-attribution__before">Edited By</span> <div class="c-footer-attribution__aside-wrap"> <picture class="c-picture"> <source srcset="https://www.drugwatch.com/wp-content/uploads/GFL00202-1-scaled-80x80-c-default.webp" type="image/webp"> <img loading="lazy" src="https://www.drugwatch.com/wp-content/uploads/GFL00202-1-scaled-80x80-c-default.jpg" alt="Sophia Clifton, editor at Drugwatch.com" class="o-image c-footer-attribution__img c-footer-attribution__img--aside" width="80" height="80" /> </picture> <div class="c-footer-attribution__info"> <span class="c-footer-attribution__name"> <a class="c-footer-attribution__link" href="https://www.drugwatch.com/authors/sophia-clifton/">Sophia Clifton</a> </span> <span class="c-footer-attribution__after">Editor</span> <ul class="c-footer-attribution__contact"> <li class="c-footer-attribution__contact-item"> <a href="mailto:sclifton@drugwatch.com" aria-label="Email" class="c-button c-footer-attribution__contact-link c-footer-attribution__contact-link--email"> <span class="c-footer-attribution__contact-icon o-icon o-icon--email"></span> <span class="c-footer-attribution__contact-copy">Email</span> </a> </li> </ul> </div> </div> </div> <div class="c-footer-attribution__item c-footer-attribution__item--reviewer"> <span class="c-footer-attribution__before">Medically Reviewed By</span> <div class="c-footer-attribution__aside-wrap"> <picture class="c-picture"> <source srcset="https://www.drugwatch.com/wp-content/uploads/kenneth_fill-80x80-c-default.webp" type="image/webp"> <img loading="lazy" src="https://www.drugwatch.com/wp-content/uploads/kenneth_fill-80x80-c-default.png" alt="Kenneth S. Fill, PharmD, MBA" class="o-image c-footer-attribution__img c-footer-attribution__img--aside" width="80" height="80" /> </picture> <div class="c-footer-attribution__info"> <span class="c-footer-attribution__name"> <a class="c-footer-attribution__link" href="https://www.drugwatch.com/contributors/kenneth-s-fill/">Kenneth S. Fill, Pharm.D., MBA</a> </span> <span class="c-footer-attribution__after">Clinical Pharmacist</span> </div> </div> </div> </div> </div> <div id="sources" class="c-sources"> <h3 class="c-sources__title">5 Cited Research Articles</h3> <div class="c-sources__lead-in"> <p class="c-sources__lead-in__copy">Drugwatch.com writers follow rigorous sourcing guidelines and cite only trustworthy sources of information, including peer-reviewed journals, court records, academic organizations, highly regarded nonprofit organizations, government reports and interviews with qualified experts. Review our <a href="/about/editorial-policy/">editorial policy</a> to learn more about our process for producing accurate, current and balanced content.</p> </div> <div id="sources-list" class="c-sources__list-wrapper"> <div class="c-sources__toggle"> <button class="c-button c-button--ghost js-showSources" data-target="sources-list"><span class="c-button__span">View Sources</span><i class="o-icon o-icon--plus c-button__icon c-button__icon--after"></i> </button> </div> <ol class="c-ol c-sources__list"> <li class="c-ol__item">Hammar v. Merck & Co. Inc. (2020, September 9). In The United States District Court For The Eastern District Of Wisconsin, Complaint for Damages and Jury Demand. Retrieved from <a href="https://aboutlawsuits-wpengine.netdna-ssl.com/wp-content/uploads/2020-09-09-Complaint.pdf" target="_blank" rel="noopener">https://aboutlawsuits-wpengine.netdna-ssl.com/wp-content/uploads/2020-09-09-Complaint.pdf</a><br /> </li> <li class="c-ol__item">U.S. National Library of Medicine. (2020, April 29). Singulair Prescription Drug Label. Retrieved from <a href="https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8c166755-7711-4df9-d689-8836a1a70885&audience=consumer#section-7" target="_blank" rel="noopener">https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8c166755-7711-4df9-d689-8836a1a70885&audience=consumer#section-7</a><br /> </li> <li class="c-ol__item">Merck Sharp & Dohme Corp. (2020, April). Medication Guide: Singulair. Retrieved from <a href="https://www.organon.com/product/usa/pi_circulars/s/singulair/singulair_mg.pdf" target="_blank" rel="noopener">https://www.organon.com/product/usa/pi_circulars/s/singulair/singulair_mg.pdf</a><br /> </li> <li class="c-ol__item">U.S. Food and Drug Administration. (2020, March 13). FDA requires Boxed Warning about serious mental health side effects for asthma and allergy drug montelukast (Singulair); advises restricting use for allergic rhinitis. Retrieved from <a href="https://www.fda.gov/drugs/drug-safety-and-availability/fda-requires-boxed-warning-about-serious-mental-health-side-effects-asthma-and-allergy-drug" target="_blank" rel="noopener">https://www.fda.gov/drugs/drug-safety-and-availability/fda-requires-boxed-warning-about-serious-mental-health-side-effects-asthma-and-allergy-drug</a><br /> </li> <li class="c-ol__item">U.S. Food and Drug Administration. (2020, March 4). FDA Requires Stronger Warning About Risk of Neuropsychiatric Events Associated with Asthma and Allergy Medication Singulair and Generic Montelukast. 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globalParams['micro_user_id'] = getCookie('mixp_id'); globalParams['micro_session_id'] = getCookie('mixp_session_id'); globalParams['js_enabled'] = 1; globalParams['ip_address'] = ''; // List of accepted query params var acceptedVals = [ "utm_source", "utm_medium", "utm_campaign", "utm_content", "utm_term", "lead_attribution" ]; // Extract additional parameters from URL window.location.href.replace(/[?&]+([^=&]+)=([^&]*)/gi, function(m,key,value) { // Only track accepted query params if (acceptedVals.indexOf(key) > -1) { globalParams[key] = value; } }); } var initQueryParams = function() { // List of accepted query params var acceptedVals = [ "utm_source", "utm_medium", "utm_campaign", "utm_content", "utm_term", "mkwid", "lead_attribution", "matchtype", "campaign_id", "adgroup_id", "creative_id", "keyword_id", "extension_id", "matchtype", "ad_network", "ad_position", "ad_placement", "ad_device", "ad_devicemodel", "ad_physical_location", "is_paid", "is_spanish", "form_id", "click_id", "audience", "aff_id", "aff_track1", "aff_track2", "aff_track3", "aff_track4", "aff_track5", "utm_s", "utm_c", "utm_m", "utm_co", "utm_t", "ad_c", "ca_id", "ag_id", "kw_id", "cr_id", "ex_id", "ad_m", "ad_n", "ad_d", "ad_dm", "ad_pos", "ad_pl", "aud", "l_attr", "is_sp", "adwords_campaignid", "adwords_adgroup", "adwords_creative", "adwords_network", "adwords_matchtype", "adwords_feeditemid", "adwords_adposition", "adwords_placement", "adwords_device", "adwords_devicemodel", "adwords_location", "campaignid", "adgroup", "creative", "network", "adposition", "device", "devicemodel", "gclid", "msclkid", "fbclid", "assist_type", "campaign_type" ]; 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