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post-234034 post type-post status-publish format-standard has-post-thumbnail hentry category-controlled-release category-dug-bioavailability category-main-blog category-peptide tag-controlled-release tag-dosage-form tag-drug-delivery tag-drug-development tag-drug-product tag-drug-product-development tag-dual-centrifugation tag-excipient tag-extended-release tag-formulation tag-lifecycle-management tag-model-based-drug-development tag-modified-release tag-nano-particle tag-nano-formulation tag-nanodelivery tag-nanoparticle tag-nanoparticles tag-nanosuspension tag-oral-dosage tag-oral-drug tag-oral-formulation tag-parenteral tag-patient-adherence tag-peptide tag-reformulation tag-scale-up tag-solid-dispersion tag-sponsor tag-stable-formulation tag-transdermal"> <div class="et_post_meta_wrapper"> <h1 class="entry-title">Applying Nanoparticle Delivery Approaches for Drug Development</h1> <p class="post-meta"><span class="published">Jun 29, 2021</span> | <a href="https://curtiscoulter.com/category/controlled-release/" rel="category tag">Controlled Release</a>, <a href="https://curtiscoulter.com/category/dug-bioavailability/" rel="category tag">Drug Bioavailability</a>, <a href="https://curtiscoulter.com/category/main-blog/" rel="category tag">Main Blog</a>, <a href="https://curtiscoulter.com/category/peptide/" rel="category tag">Peptide</a> | <span class="comments-number"><a href="https://curtiscoulter.com/applying-nanoparticle-delivery-approaches/#respond">0 comments</a></span></p><img src="https://curtiscoulter.wpenginepowered.com/wp-content/uploads/2020/06/christina-victoria-craft-WHSnkIwWpec-unsplash-1080x675.jpg" alt="Nanodelivery" class="" width="1080" height="675" /> </div>  <div class="entry-content"> <div id="et-boc" class="et-boc"> <div class="et-l et-l--post"> <div class="et_builder_inner_content et_pb_gutters3"> <div class="et_pb_section et_pb_section_0 et_section_regular" > <div class="et_pb_row et_pb_row_0"> <div class="et_pb_column et_pb_column_4_4 et_pb_column_0 et_pb_css_mix_blend_mode_passthrough et-last-child"> <div class="et_pb_module et_pb_text et_pb_text_0 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><p><strong>Nanomedicines leading the way</strong></p> <p>Nanotechnology offers multiple benefits in treating chronic diseases by site-specific, and target-oriented delivery of medicines. Nano-delivery systems utilized in drug development are very much still relatively new commercial approach. There are many opportunities and a few notable successes in targeted delivery of specific therapeutic agents in a controlled manner.</p> <p><span style="font-size: 18px;">The continued development of nanomedicines has the potential to provide numerous benefits. These include improved efficacy, bioavailability, dose–response, targeting ability, personalization, and safety compared to conventional medicines. There are a number of outstanding applications of the nanomedicines treating of various diseases but development still poses its own set of complex challenges. Approximately 40% of drugs on the market place and a high percentage of APIs in development are poorly soluble. Optimization of drug solubility and BA of therapeutics stands as one of the top challenges faced by the pharmaceutical and biotech industry today.</span></p> <p><span style="font-size: 18px;">By way of followup, this week’s available deck is titled “Applying Nanoparticle Delivery Approaches” from Sharad Murdande at Pfizer. Sharad was a past speaker at our Global Drug Bioavailability Enhancement Summit. This presentation overviews methods for nanosuspension preparation / characterization, attrition wet milling process for extemporaneous preparation of nanocrystalline suspensions for phase I clinical studies, factors affecting nanosuspension preparation and properties of compounds used in nanocrystalline suspension formulation. It also examines investigation thermodynamic and kinetic properties of crystalline nanoparticles and nanocrystal solubility method development with a host of examples. </span></p></div> </div> <div class="et_pb_module et_pb_code et_pb_code_0 et_pb_text_align_center"> <div class="et_pb_code_inner"><iframe src="https://drive.google.com/file/d/1b851UztiNCAte7OpiLOmIk9ezLZKeVNN/preview" width="744" height="500"></iframe> </div> </div>  </div>  </div>  </div> <div class="et_pb_section et_pb_section_2 et_pb_section_parallax et_section_regular" > <div class="et_pb_row et_pb_row_1 et_pb_equal_columns et_pb_gutters2"> <div class="et_pb_column et_pb_column_4_4 et_pb_column_1 et_pb_css_mix_blend_mode_passthrough et-last-child"> <div class="et_pb_module et_pb_text et_pb_text_1 et_pb_text_align_justified et_pb_bg_layout_dark"> <div class="et_pb_text_inner"><h3 style="text-align: center;"><span style="color: #000000;">2024 Controlled & Modified Drug Release Summit</span></h3> <h3 style="text-align: center;"><span style="color: #000000;">(May 14-15, 2024, Princeton, NJ)</span></h3> <p> </p></div> </div> <div class="et_pb_module et_pb_text et_pb_text_2 et_pb_text_align_justified et_pb_bg_layout_dark"> <div class="et_pb_text_inner"><h2><span style="font-size: medium;"><span style="color: #000000; text-align: justify; font-family: 'Open Sans', Helvetica, Arial, Lucida, sans-serif;"><span style="font-size: medium; color: #000000; font-family: Open Sans, Helvetica, Arial, Lucida, sans-serif;"><b>Interested to improve the performance of your drug products? Learn 2 years of new drug product development approaches at the 2024 Summit this </b></span><span style="color: #000000; font-family: Open Sans, Helvetica, Arial, Lucida, sans-serif; font-size: medium;"><b>coming</b></span><span style="font-size: medium; color: #000000; font-family: Open Sans, Helvetica, Arial, Lucida, sans-serif;"><b> May both in-person & virtual.</b></span></span></span></h2></div> </div>  </div>  </div> <div class="et_pb_row et_pb_row_2 et_pb_equal_columns et_pb_gutters2"> <div class="et_pb_column et_pb_column_1_2 et_pb_column_2 et_pb_css_mix_blend_mode_passthrough"> <div class="et_pb_module et_pb_text et_pb_text_3 et_pb_text_align_justified et_pb_bg_layout_dark"> <div class="et_pb_text_inner"><h2 style="text-align: left;"><span style="color: #000000; font-size: large; font-family: inherit; font-weight: normal;">Join 160+ leading drug delivery, formulation and development experts and hear 30+ expert sessions. Gain over 2 years worth of new drug product development strategies, formulation approaches, delivery technologies and regulatory updates while decreasing drug product time-to-market in just 2 short days (all available on-demand)!</span></h2> <h2 style="text-align: left;"><span style="color: #000000; font-size: large; font-family: inherit; font-weight: normal;">Save up-to 45% on attendance before Friday 29th September, 2023. Likewise, have a platform technology you would like to explore showcasing to the wider audience this May? 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