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Sabour</title> <meta name="description" content="Search results for: Smain Sabour"> <meta name="keywords" content="Smain Sabour"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler 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id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="Smain Sabour"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 10</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: Smain Sabour</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">10</span> Antimicrobial Activity of Olive Mill Wastewater Fractions</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Chahinez%20Ait%20Si%20Said">Chahinez Ait Si Said</a>, <a href="https://publications.waset.org/abstracts/search?q=Ouassila%20Touafek"> Ouassila Touafek</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohamed%20Reda%20Zahi"> Mohamed Reda Zahi</a>, <a href="https://publications.waset.org/abstracts/search?q=Smain%20Sabour"> Smain Sabour</a>, <a href="https://publications.waset.org/abstracts/search?q=%E2%80%8EMohamed%20El%20Hattab%20%E2%80%8E"> ‎Mohamed El Hattab ‎</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Oil mill wastewater (OMW) is a major effluent of the olive industry resulting from olive ‎oil extraction which is a great source for the development of new drugs. The present ‎study aimed to evaluate the antimicrobial activity of seven different fractions separated ‎from OMW extract. The sample was recovered from an oil mill in the Blida region ‎‎(Algeria). A crude ethyl acetate extract was prepared from OMW according to a well-‎established protocol; the yield of the extract obtained was 4%. From the extract, ‎different fractions were prepared by fractionating the total extract with an open column ‎chromatography. The obtained fractions were submitted to antimicrobial activity ‎screening in a comparative purpose. All the fractions obtained show great antimicrobial ‎potential. ‎Phytochemical study of the different fractions was assessed by evaluating the total ‎phenolic compounds for all fractions studied as the main compounds found in OMW ‎were phenols like hydroxytyrosol, tyrosol, phenolic acids like caffeic, quinic and ferulic ‎acids which show great therapeutic activities. ‎ <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=olive%20mill%20wastewater" title="olive mill wastewater">olive mill wastewater</a>, <a href="https://publications.waset.org/abstracts/search?q=fractionation" title=" fractionation"> fractionation</a>, <a href="https://publications.waset.org/abstracts/search?q=total%20phenolic%20compound" title=" total phenolic compound"> total phenolic compound</a>, <a href="https://publications.waset.org/abstracts/search?q=antimicrobial%20activity" title=" antimicrobial activity"> antimicrobial activity</a> </p> <a href="https://publications.waset.org/abstracts/167613/antimicrobial-activity-of-olive-mill-wastewater-fractions" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/167613.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">104</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">9</span> Chemical Composition of Essential Oil from Lavandula stoechas and Lavandula multifida Growing Wild in Algeria</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Fatima%20Benchikh-Amiraa">Fatima Benchikh-Amiraa</a>, <a href="https://publications.waset.org/abstracts/search?q=Hocine%20Laouerb"> Hocine Laouerb</a>, <a href="https://publications.waset.org/abstracts/search?q=Smain%20Amiraa"> Smain Amiraa</a>, <a href="https://publications.waset.org/abstracts/search?q=Guido%20Flaminic"> Guido Flaminic </a> </p> <p class="card-text"><strong>Abstract:</strong></p> The essential oils of the aerial parts of Lavandula multifida and L. stoechas were extracted at the full bloom stage by hydrodistillation and theirs chemical compositions were estimated by means of gas chromatography–mass spectrometry (GC–MS). A total of 46 and 67 constituents were identified representing 95.5% and 98.2% of the total oils, respectively. The main components of L. multifida oil were carvacrol (63.8%), beta-bisabolene (8.7%), spathulenol (6.2%), caryophyllene oxide (3.6%) and linalool (2.9%). The oil of L. stoechas was dominated by fenchone (63.9%), camphor (7.8%), 1,8-cineole (5.3%) and myrtenyl acetate (4.2). <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=essential%20oils" title="essential oils">essential oils</a>, <a href="https://publications.waset.org/abstracts/search?q=Lavandula%20multifida" title=" Lavandula multifida"> Lavandula multifida</a>, <a href="https://publications.waset.org/abstracts/search?q=Lavandula%20stoechas" title=" Lavandula stoechas"> Lavandula stoechas</a>, <a href="https://publications.waset.org/abstracts/search?q=chemical%20and%20molecular%20engineering" title=" chemical and molecular engineering"> chemical and molecular engineering</a> </p> <a href="https://publications.waset.org/abstracts/14257/chemical-composition-of-essential-oil-from-lavandula-stoechas-and-lavandula-multifida-growing-wild-in-algeria" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/14257.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">429</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">8</span> Essential Oil Analysis of the Aerial Parts of Sideritis incana and Calamitha hispidula </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Smain%20Amiraa">Smain Amiraa</a>, <a href="https://publications.waset.org/abstracts/search?q=Hocine%20Laouerb"> Hocine Laouerb</a>, <a href="https://publications.waset.org/abstracts/search?q=Fatima%20Benchikh-Amiraa"> Fatima Benchikh-Amiraa</a>, <a href="https://publications.waset.org/abstracts/search?q=Guido%20Flaminic"> Guido Flaminic</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The aerial parts of Sideritis incana and Calamintha hispidula at the flowering stage were submitted to hydrodistillation in a Clevenger–type apparatus for 3 hours and the chemical composition of the essential oil was analyzed by GC coupled to GC-MS. The essential oil contained a total of 99 constituents for S. incana and 31 for C. hispidula representing 95.7% and 99.6 of the total oils, rerspectively. The mains components of S. incana oil were linalool (25.2), cedrol (13.7%), geraniol (7%) and α-terpineol (5.4%). The chemical constituents of the oil from C. hispidula were predominated by pulegone (43.2%), isomenthone (36%), piperitone (3.2%), limonene (2.6%) and 4-terpineol (2.5%). The results revealed that the oil of the plants is characterized by the presence of many important components which could be applied in food, pharmaceutical and perfume industry. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=essential%20oils" title="essential oils">essential oils</a>, <a href="https://publications.waset.org/abstracts/search?q=Calamintha%20hispidula" title=" Calamintha hispidula"> Calamintha hispidula</a>, <a href="https://publications.waset.org/abstracts/search?q=Sideritis%20incana" title=" Sideritis incana"> Sideritis incana</a>, <a href="https://publications.waset.org/abstracts/search?q=chemical%20and%20molecular%20engineering" title=" chemical and molecular engineering"> chemical and molecular engineering</a> </p> <a href="https://publications.waset.org/abstracts/14255/essential-oil-analysis-of-the-aerial-parts-of-sideritis-incana-and-calamitha-hispidula" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/14255.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">246</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7</span> Background Knowledge and Reading Comprehension in ELT Classes: A Pedagogical Perspective</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Davoud%20Ansari%20Kejal">Davoud Ansari Kejal</a>, <a href="https://publications.waset.org/abstracts/search?q=Meysam%20Sabour"> Meysam Sabour</a> </p> <p class="card-text"><strong>Abstract:</strong></p> For long, there has been a belief that a reader can easily comprehend a text if he is strong enough in vocabulary and grammatical knowledge but there was no account for the ability of understanding different subjects based on readers’ understanding of the surrounding world which is called world background knowledge. This paper attempts to investigate the reading comprehension process applying the schema theory as an influential factor in comprehending texts, in order to prove the important role of background knowledge in reading comprehension. Based on the discussion, some teaching methods are suggested for employing world background knowledge for an elaborated teaching of reading comprehension in an active learning environment in EFL classes. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=background%20knowledge" title="background knowledge">background knowledge</a>, <a href="https://publications.waset.org/abstracts/search?q=reading%20comprehension" title=" reading comprehension"> reading comprehension</a>, <a href="https://publications.waset.org/abstracts/search?q=schema%20theory" title=" schema theory"> schema theory</a>, <a href="https://publications.waset.org/abstracts/search?q=ELT%20classes" title=" ELT classes"> ELT classes</a> </p> <a href="https://publications.waset.org/abstracts/6277/background-knowledge-and-reading-comprehension-in-elt-classes-a-pedagogical-perspective" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/6277.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">456</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">6</span> Study of Changes in the Pulsation Period of Six Cepheid Variables</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mohamed%20Abdel%20Sabour">Mohamed Abdel Sabour</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohamed%20Nouh"> Mohamed Nouh</a>, <a href="https://publications.waset.org/abstracts/search?q=Ian%20Stevans"> Ian Stevans</a>, <a href="https://publications.waset.org/abstracts/search?q=Essam%20Elkholy"> Essam Elkholy</a> </p> <p class="card-text"><strong>Abstract:</strong></p> We study the period change of six Cepheids using 19376 accurate flux observations of the Solar Mass Ejection Imager (SMEI) onboard the Coriolis spacecraft. All observations for the six Cepheids have been derived as templates for each star, independent of the specific sites utilized to establish and update the O-C values. Sometimes, sinusoidal patterns are superimposed on the star's O-C changes, which cannot be regarded as random fluctuations in the pulsation period. Random period changes were detected and computed using Eddington's and Plakidis's approaches. A comparison of the observed and predicted period change reveals a good agreement with some published models and a very substantial divergence with others. Between the reported period change and that estimated by the current technique, a linear fit with a correlation coefficient of 90.08 percent was obtained. The temporal rate of period change in Cepheid stars might be connected to how well these stars' mass losses are known today. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cepheids" title="cepheids">cepheids</a>, <a href="https://publications.waset.org/abstracts/search?q=period%20change" title=" period change"> period change</a>, <a href="https://publications.waset.org/abstracts/search?q=mass%20loss" title=" mass loss"> mass loss</a>, <a href="https://publications.waset.org/abstracts/search?q=O-C%20changes" title=" O-C changes"> O-C changes</a>, <a href="https://publications.waset.org/abstracts/search?q=period%20change" title=" period change"> period change</a>, <a href="https://publications.waset.org/abstracts/search?q=mass%20loss" title=" mass loss"> mass loss</a>, <a href="https://publications.waset.org/abstracts/search?q=O-C" title=" O-C"> O-C</a> </p> <a href="https://publications.waset.org/abstracts/187496/study-of-changes-in-the-pulsation-period-of-six-cepheid-variables" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/187496.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">40</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5</span> Numerical Study of Off-Design Performance of a Highly Loaded Low Pressure Turbine Cascade</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Shidvash%20Vakilipour">Shidvash Vakilipour</a>, <a href="https://publications.waset.org/abstracts/search?q=Mehdi%20Habibnia"> Mehdi Habibnia</a>, <a href="https://publications.waset.org/abstracts/search?q=Rouzbeh%20Riazi"> Rouzbeh Riazi</a>, <a href="https://publications.waset.org/abstracts/search?q=Masoud%20Mohammadi"> Masoud Mohammadi</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohammad%20H.%20Sabour"> Mohammad H. Sabour</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The flow field passing through a highly loaded low pressure (LP) turbine cascade is numerically investigated at design and off-design conditions. The Field Operation And Manipulation (OpenFOAM) platform is used as the computational Fluid Dynamics (CFD) tool. Firstly, the influences of grid resolution on the results of k-ε, k-ω, and LES turbulence models are investigated and compared with those of experimental measurements. A numerical pressure under-shoot is appeared near the end of blade pressure surface which is sensitive to grid resolution and flow turbulence modeling. The LES model is able to resolve separation on a coarse and fine grid resolutions. Secondly, the off-design flow condition is modeled by negative and positive inflow incidence angles. The numerical experiments show that a separation bubble generated on blade pressure side is predicted by LES. The total pressure drop is also been calculated at incidence angle between -20◦ and +8◦. The minimum total pressure drop is obtained by k-ω and LES at the design point. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=low%20pressure%20turbine" title="low pressure turbine">low pressure turbine</a>, <a href="https://publications.waset.org/abstracts/search?q=off-design%20performance" title=" off-design performance"> off-design performance</a>, <a href="https://publications.waset.org/abstracts/search?q=openFOAM" title=" openFOAM"> openFOAM</a>, <a href="https://publications.waset.org/abstracts/search?q=turbulence%20modeling" title=" turbulence modeling"> turbulence modeling</a>, <a href="https://publications.waset.org/abstracts/search?q=flow%20separation" title=" flow separation"> flow separation</a> </p> <a href="https://publications.waset.org/abstracts/26688/numerical-study-of-off-design-performance-of-a-highly-loaded-low-pressure-turbine-cascade" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/26688.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">362</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4</span> Shear Layer Investigation through a High-Load Cascade in Low-Pressure Gas Turbine Conditions</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mehdi%20Habibnia%20Rami">Mehdi Habibnia Rami</a>, <a href="https://publications.waset.org/abstracts/search?q=Shidvash%20Vakilipour"> Shidvash Vakilipour</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohammad%20H.%20Sabour"> Mohammad H. Sabour</a>, <a href="https://publications.waset.org/abstracts/search?q=Rouzbeh%20Riazi"> Rouzbeh Riazi</a>, <a href="https://publications.waset.org/abstracts/search?q=Hossein%20Hassannia"> Hossein Hassannia </a> </p> <p class="card-text"><strong>Abstract:</strong></p> This paper deals with the steady and unsteady flow behavior on the separation bubble occurring on the rear portion of the suction side of T106A blade. The first phase was to implement the steady condition capturing the separation bubble. To accurately predict the separated region, the effects of three different turbulence models and computational grids were separately investigated. The results of Large Eddy Simulation (LES) model on the finest grid structure are acceptably in a good agreement with its relevant experimental results. The second phase is mainly to address the effects of wake entrance on bubble disappearance in unsteady situation. In the current simulations, from what was suggested in an experiment, simulating the flow unsteadiness, with concentrations on small scale disturbances instead of simulating a complete oncoming wake, is the key issue. Subsequently, the results from the current strategy to apply the effects of the wake and two other experimental work were compared to be in a good agreement. Between the two experiments, one of them deals with wake passing unsteady flow, and the other one implements experimentally the same approach as the current Computational Fluid Dynamics (CFD) simulation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=low-pressure%20turbine%20cascade" title="low-pressure turbine cascade">low-pressure turbine cascade</a>, <a href="https://publications.waset.org/abstracts/search?q=large-Eddy%20simulation%20%28LES%29" title=" large-Eddy simulation (LES)"> large-Eddy simulation (LES)</a>, <a href="https://publications.waset.org/abstracts/search?q=RANS%20turbulence%20models" title=" RANS turbulence models"> RANS turbulence models</a>, <a href="https://publications.waset.org/abstracts/search?q=unsteady%20flow%20measurements" title=" unsteady flow measurements"> unsteady flow measurements</a>, <a href="https://publications.waset.org/abstracts/search?q=flow%20separation" title=" flow separation"> flow separation</a> </p> <a href="https://publications.waset.org/abstracts/62574/shear-layer-investigation-through-a-high-load-cascade-in-low-pressure-gas-turbine-conditions" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/62574.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">305</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3</span> Hypotensive, Free Radical Scavenging and Anti-Lipid Peroxidation Activities of Crataegus azarolus L. Leaves Extracts Growing in Algeria</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Amel%20Bouaziz">Amel Bouaziz</a>, <a href="https://publications.waset.org/abstracts/search?q=Seddik%20Khennouf"> Seddik Khennouf</a>, <a href="https://publications.waset.org/abstracts/search?q=Mussa%20Abu%20Zarga"> Mussa Abu Zarga</a>, <a href="https://publications.waset.org/abstracts/search?q=Shtayway%20Abdalla"> Shtayway Abdalla</a>, <a href="https://publications.waset.org/abstracts/search?q=Saliha%20Djidel"> Saliha Djidel</a>, <a href="https://publications.waset.org/abstracts/search?q=Assia%20Bentahar"> Assia Bentahar</a>, <a href="https://publications.waset.org/abstracts/search?q=Saliha%20Dahamna"> Saliha Dahamna</a>, <a href="https://publications.waset.org/abstracts/search?q=Smain%20Amira"> Smain Amira</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The present study aimed to evaluate the hypotensive and the in vitro antioxidant activities of Crataegus azarolus L. (Rosaceae), a plant widely used as natural remedy for hypertension in folk medicine. The antioxidant potential of methanolic extract (ME)and its three fractions of Chloroform (CHE), ethyl acetate (EAE)and water (AqE) have been investigated using several assays, including the DPPH scavenging, ABTS scavenging, hydroxyl radical scavenging. Inhibition of lipid peroxidation was performed by the β-carotene bleaching assay, ferric thiocyanate method and thiobarburic acid method. Total phenolic and total flavonoid contents of the extracts were estimated using Folin-Chiocalteu reagent and AlCl3, respectively. EAE extract showed the highest polyphenolic and flavonoids contents (396,04±1.20 mg GAE/g of dry extract and 32,73 ± 0.03mg QE/g of dry extract) respectively. Similarly, this extract possessed the highest scavenging activity for DPPH radical (IC 50 = 0,006±0,0001mg /ml), ABTS radical (IC50=0.0035±0,0007 mg/ml) and hydroxyl radical(IC 50=0,283± 0.01 mg/ml). In addition, the EAE exhibited the highest antioxidant activity in the inhibition of linoleic acid/ß-carotene coupled oxidation (89,21%), lipid peroxidation in the ferric thiocyanate(FTC) method (90.13%), and thio-barbituric acid (TBA) method (74.23%). Intravenous administration of Me and EAE decreased mean arterial blood pressure, systolic and diastolic blood pressure in anesthetized rats dose-dependently, at the dose range of 0.4 to 12 mg/kg. The mean arterial blood pressure dropped by 27.58 and 39.37% for ME and EAE, respectively. In conclusion, The present study supported the significant potential to use C. azarolus by-products as a source of natural antioxidants and provides scientific justification for its traditional uses as cardio-protective and anti-hypertensive remedy. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Crataegus%20azarolus" title="Crataegus azarolus">Crataegus azarolus</a>, <a href="https://publications.waset.org/abstracts/search?q=polyphenols" title=" polyphenols"> polyphenols</a>, <a href="https://publications.waset.org/abstracts/search?q=flavonoids" title=" flavonoids"> flavonoids</a>, <a href="https://publications.waset.org/abstracts/search?q=hypertension" title=" hypertension"> hypertension</a>, <a href="https://publications.waset.org/abstracts/search?q=antioxidant%20activity" title=" antioxidant activity"> antioxidant activity</a>, <a href="https://publications.waset.org/abstracts/search?q=free%20radicals" title=" free radicals"> free radicals</a>, <a href="https://publications.waset.org/abstracts/search?q=peroxidation" title=" peroxidation"> peroxidation</a> </p> <a href="https://publications.waset.org/abstracts/10557/hypotensive-free-radical-scavenging-and-anti-lipid-peroxidation-activities-of-crataegus-azarolus-l-leaves-extracts-growing-in-algeria" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/10557.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">347</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Synthesis of Highly Stable Multi-Functional Iron Oxide Nanoparticles for Active Mitochondrial Targeting in Immunotherapy</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Masome%20Moeni">Masome Moeni</a>, <a href="https://publications.waset.org/abstracts/search?q=Roya%20Abedizadeh"> Roya Abedizadeh</a>, <a href="https://publications.waset.org/abstracts/search?q=Elham%20Aram"> Elham Aram</a>, <a href="https://publications.waset.org/abstracts/search?q=Hamid%20Sadeghi-Abandansari"> Hamid Sadeghi-Abandansari</a>, <a href="https://publications.waset.org/abstracts/search?q=Davood%20Sabour"> Davood Sabour</a>, <a href="https://publications.waset.org/abstracts/search?q=Robert%20Menzel"> Robert Menzel</a>, <a href="https://publications.waset.org/abstracts/search?q=Ali%20Hassanpour"> Ali Hassanpour</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Mitochondria- targeting immunogenic cell death inducers (MT-ICD) have been designed to trigger intrinsic apoptosis signalling pathway in malignant cells and revive the antitumour immune system. MT-ICD inducers have considered to be non-specific, which can deteriorate the ability to initiate mitochondria-selective oxidative stress, causing high toxicity. Iron oxide nanoparticles (IONPs) can be an ideal candidate as vehicles for utilizing in immunotherapy due to their biocompatibility, modifiable surface chemistry, magnetic characteristics and multi-functional applications in single platform. These types of NPs can facilitate a real time imaging which can provide an effective strategy to analyse pharmacokinetic parameters of nano-formula, including blood circulation time, targeted and controlled release at tumour microenvironment. To our knowledge, the conjugation of IONPs with MT-ICD and oxaliplatin (a chemotherapeutic agent used for the treatment of colorectal cancer) for immunotherapy have not been investigated. Herein, IONPs were generated via co-precipitation reaction at high temperatures, followed by coating the colloidal suspension with tetraethyl orthosilicate and 3-aminopropyltriethoxysilane to optimize their bio-compatibility, preventing aggregation and maintaining stability at physiological pH, then functionalized with (3-carboxypropyl) triphenyl phosphonium bromide for mitochondrial delivery. Analytical results demonstrated the successful process of IONPs functionalization. In particular, the colloidal particles of doped IONPs exhibited an excellent stability and dispersibility. The resultant particles were also successfully loaded with the oxaliplatin for an active mitochondrial targeting in immunotherapy, resulting in well-maintained super-paramagnetic characteristics and stable structure of the functionalized IONPs with nanoscale particle sizes. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Immunotherapy" title="Immunotherapy">Immunotherapy</a>, <a href="https://publications.waset.org/abstracts/search?q=mitochondria" title=" mitochondria"> mitochondria</a>, <a href="https://publications.waset.org/abstracts/search?q=cancer" title=" cancer"> cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=iron%20oxide%20nanoparticle" title=" iron oxide nanoparticle"> iron oxide nanoparticle</a> </p> <a href="https://publications.waset.org/abstracts/166577/synthesis-of-highly-stable-multi-functional-iron-oxide-nanoparticles-for-active-mitochondrial-targeting-in-immunotherapy" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/166577.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">74</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Synthesis of Multi-Functional Iron Oxide Nanoparticles for Targeted Drug Delivery in Cancer Treatment</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Masome%20Moeni">Masome Moeni</a>, <a href="https://publications.waset.org/abstracts/search?q=Roya%20Abedizadeh"> Roya Abedizadeh</a>, <a href="https://publications.waset.org/abstracts/search?q=Elham%20Aram"> Elham Aram</a>, <a href="https://publications.waset.org/abstracts/search?q=Hamid%20Sadeghi-Abandansari"> Hamid Sadeghi-Abandansari</a>, <a href="https://publications.waset.org/abstracts/search?q=Davood%20Sabour"> Davood Sabour</a>, <a href="https://publications.waset.org/abstracts/search?q=Robert%20Menzel"> Robert Menzel</a>, <a href="https://publications.waset.org/abstracts/search?q=Ali%20Hassanpour"> Ali Hassanpour</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Significant number of studies and preclinical research in formulation of cancer nano-pharmaceutics have led to an improvement in cancer care. Nonetheless, the antineoplastic agents have ‘failed to live up to its promise’ since their clinical performance is moderately low. For almost ninety years, iron oxide nanoparticles (IONPS) have managed to keep its reputation in clinical application due to their low toxicity, versatility and multi-modal capabilities. Drug Administration approved utilization of IONPs for diagnosis of cancer as contrast media in magnetic resonance imaging, as heat mediator in magnetic hyperthermia and for the treatment of iron deficiency. Furthermore, IONPs have high drug-loading capacity, which makes them good candidates as therapeutic agent transporters. There are yet challenges to overcome for successful clinical application of IONPs, including stability of drug and poor delivery, which might lead to (i) drug resistance, (ii) shorter blood circulation time, and (iii) rapid elimination and adverse side effects from the system. In this study, highly stable and super paramagnetic IONPs were prepared for efficient and targeted drug delivery in cancer treatment. The synthesis procedure was briefly involved the production of IONPs via co-precipitation followed by coating with tetraethyl orthosilicate and 3-aminopropylethoxysilane and grafting with folic acid for stability targeted purposes and controlled drug release. Physiochemical and morphological properties of modified IONPs were characterised using different analytical techniques. The resultant IONPs exhibited clusters of 10 nm spherical shape crystals with less than 100 nm size suitable for drug delivery. The functionalized IONP showed mesoporous features, high stability, dispersibility and crystallinity. Subsequently, the functionalized IONPs were successfully loaded with oxaliplatin, a chemotherapeutic agent, for a controlled drug release in an actively targeting cancer cells. FT-IR observations confirmed presence of oxaliplatin functional groups, while ICP-MS results verified the drug loading was ~ 1.3%. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cancer%20treatment" title="cancer treatment">cancer treatment</a>, <a href="https://publications.waset.org/abstracts/search?q=chemotherapeutic%20agent" title=" chemotherapeutic agent"> chemotherapeutic agent</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20delivery" title=" drug delivery"> drug delivery</a>, <a href="https://publications.waset.org/abstracts/search?q=iron%20oxide" title=" iron oxide"> iron oxide</a>, <a href="https://publications.waset.org/abstracts/search?q=multi-functional%20nanoparticle" title=" multi-functional nanoparticle"> multi-functional nanoparticle</a> </p> <a href="https://publications.waset.org/abstracts/166578/synthesis-of-multi-functional-iron-oxide-nanoparticles-for-targeted-drug-delivery-in-cancer-treatment" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/166578.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">82</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational anniversary</a></li> 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