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as a Method * define function as object methods * @type {Object} */ window.digitalData = { user: {}, page: {}, merchandising: {}, getQueryParam : function (param) { var index, key, value, hash; var hashes = window.location.href.slice(window.location.href.indexOf('?') + 1).split('&'); for (index = 0; index < hashes.length; index++) { hash = hashes[index].split('='); key = hash[0]; value = hash[1]; if (key.toUpperCase() === param.toUpperCase()) return value; } return ''; }, getValOnce: function (value, cookieName, expiry, timeUnit) { var currentDate = new Date; var currentCookieValue; // timeUnit of 'm' is minutes represented in milliseconds // thus 86400000 = 24 hours = 1 day var interval = timeUnit == 'm' ? 60000 : 86400000; cookieName = cookieName ? cookieName : 'digitaldata_gvo'; value = value ? value : ''; expiry = expiry ? expiry : 0; currentCookieValue = this.getCookie(cookieName); if (value) { currentDate.setTime(currentDate.getTime() + expiry * interval); this.setCookie(cookieName, value, expiry == 0 ? 0 : currentDate); } return value == currentCookieValue ? '' : value; }, getCookie: function (key) { var result = ""; var cookies = document.cookie ? document.cookie.split('; ') : []; for (var i = 0; i < cookies.length; i++) { var parts = cookies[i].split('='); var name = decodeURIComponent(parts.shift()); var cookie = parts ? parts.join('=') : []; // Prevent storing or parsing of a cookie that we couldn't decode. if (cookie && key === name) { // removes surrounding quotes if (cookie.indexOf('"') === 0) { // This is a quoted cookie as according to RFC2068, unescape... cookie = cookie.slice(1, -1).replace(/\\"/g, '"').replace(/\\\\/g, '\\'); } // parse utf8 characters try { cookie = decodeURIComponent(cookie); } catch (e) {} result = cookie; // we found it, don't bother looking at other cookies break; } } return result; }, setCookie : function(name, value, numDays){ if ( !numDays ) numDays = 31; var expires = new Date(); expires.setTime(expires.getTime() + (1000 * 60 * 60 * 24 * numDays)); document.cookie = name+ '=' + escape(value) + '; path=/; expires=' + expires.toGMTString() + '; domain=.' + this.getMasterDomain() + ';'; }, /** * get the master domain based on business rules */ getMasterDomain : function () { // default the master domain var masterDomain = 'thermofisher.com'; // check for alternate domain portion of URL var regexMatch = document.location.hostname.match(/\.(thermofisher)\.(cn)/i); if (regexMatch !== null) { masterDomain = regexMatch[1] + '.' + regexMatch[2]; } return masterDomain; }, /** * Check if init has been initiated once * @type {Boolean} */ initted: false, /** * @return {Array} method returns an array of a given object's key properties */ init: function () { this.page.country = this.getCookie("CK_ISO_CODE") || 'us'; this.page.language = this.getCookie('CK_LANG_CODE') || 'en'; this.page.siteName = 'thermo'; //hard coded this.initMerchandisingData(); this.initUserData(); this.displayDigitalData(); this.formSubmitEvent(); }, //specific function to set type of the page // need specific function to keep page type separate from other page attributes setPageType: function (type) { this.setPageAttribute('type', type); }, // generic function to set page attributes setPageAttribute: function (key, value) { this.page[key] = value; }, // display digitalData object displayDigitalData: function () { }, // specific function to add an object to digitalData addDigitDataObject: function (key, object) { this[key] = object; }, addChildObjectAttribute: function(child, key, value){ this[child][key] = value; }, initUserData: function(){ var gigyaCookie = this.getCookie("identity_uid"); this.user.gigyaId = ""; this.user.loginStatus = "anonymous"; if( gigyaCookie != ""){ this.user.gigyaId = gigyaCookie; this.user.loginStatus = "logged in"; } }, /** * Check if init has been initiated once * @type {Boolean} */ merchandisingDataInitted: false, initMerchandisingData: function () { // read cid and icid value from session cookie this.merchandising.icid = this.getCookie('s_ev21_tc'); this.merchandising.cid = this.getCookie('s_cmp_tc'); // EMID value this.merchandising.emid = this.getQueryParam("emid"); // referrer by domain if (typeof document.referrer !== 'undefined' && document.referrer.length > 0) { var masterDomain = this.getMasterDomain(); var refReg = document.referrer; var referrerDomain = refReg.match(/:\/\/([^/]+)\//); if (referrerDomain !== null && referrerDomain[1].indexOf(masterDomain) == -1) { this.merchandising.referrer = referrerDomain; } } document.addEventListener('registerMerchandisingData', function (event) { for (var key in event.detail) { console.log("Listener data copied", key, event.detail[key] ); digitalData.merchandising[key] = event.detail[key]; } // Map some analytics attributes to merchandising session attributes digitalData.merchandising.sessionId = digitalData.merchandising.analyticsVisitorID; digitalData.merchandising.s_vi_low = digitalData.merchandising.analyticsVisitorIDLow; digitalData.merchandising.s_vi_high = digitalData.merchandising.analyticsVisitorIDHigh; console.log("digitalData: Captured registerMerchandisingData event"); digitalData.merchandisingDataInitted = true; // Call emailCampaignRecord if the digitalDataAnalyticsListener object is loaded if (typeof digitalDataAnalyticsListener != "undefined") { console.log("digitalData: Calling email campaign record"); digitalDataAnalyticsListener.emailCampaignRecord(); } }); }, formSubmitEvent: function () { var formId = this.getQueryParam("form-submit-id"); if ((formId) && formId !== "" && formId !== null) { var eventDetail = { detail: { form: { id: formId } } }; var formSubmitEvent = new CustomEvent('formSubmit', eventDetail); console.log('form submit event started'); document.dispatchEvent(formSubmitEvent); console.log('form submit event fired', eventDetail); //flush grepToken from Session Storage sessionStorage.removeItem('grepTokenSO'); } }, modalVideoEvent: function (videoId) { if (((videoId) && videoId !== "" && videoId !== null)) { var eventDetail = { detail: { video: { playerId: videoId } } }; var modalVideoEvent = new CustomEvent('videoPlayerLoaded', eventDetail); document.dispatchEvent(modalVideoEvent); } }, customClickEvent: function (clickDetail) { if (((clickDetail) && clickDetail !== "" && clickDetail !== null)) { var eventDetail = { detail: { CustomLink: { linkName: clickDetail } } } var customClickEvent = new CustomEvent('customLinkClicks', eventDetail); document.dispatchEvent(customClickEvent); } } } })(); window.digitalData.init(); </script>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_25"); </script> <script type="text/javascript"> var localizedStrings = { "ACCEPTANCE": "Acceptance of Terms of Use", "BTN_AGREE": "Agree", "BTN_DISAGREE": "Disagree", "PROCESSING_MESSAGE" :"processing ... please wait ...", "ADD_TO_CART_QUANTITY_ERROR":"You must provide a quantity to add an item to the cart", "ADD_TO_CART_VALID_QUANTITY_ERROR":"You must provide a valid quantity to add an item to the cart", "VIEW_CART" :"View cart & checkout", "VIEW_CONTACT_DETAIL" :"View Contact Details", "ADD_TO_CART_NOTIFICATION":"Add to Cart Notification", "UPDATE_CART" :"Update Cart", "PRINCIPAL_INVESTIGATOR":"Principal Investigator", "PRINCIPAL_INVESTIGATOR_TEAM_LEADER":"Principal Investigator or Team Leader", "PRINCIPAL_INVESTIGATOR_CHIEF":"Principal Investigator or Chief", "EMAIL_ERROR_1" :"Please Provide Collegues Email", "EMAIL_ERROR_2" :"Please enter a valid colleague email address", "EMAIL_ERROR_3" :"Please Provide Your Email", "EMAIL_ERROR_4" :"Please enter a valid email address", "ERROR_OCCURED_MESSAGE" :"The following errors occured", "NEXT" :"Next", "PREVIOUS" :"Prev", "IMAGE" :"Image", "SAVE_TO_LIST_ERROR_1" :"Please enter a list name.", "SAVE_TO_LIST_ERROR_2" :"Please enter a different list name that does not include the following: ?,/,\\,%,^,!", "MINICART_ERROR_1" :"Unable to connect to eCommerce system. 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<span class="current-img"> 1 </span> / <span class="img-total-count"> 1</span></p> </div> <div class = "verification-certificate hide" > <span class="icon-certification"></span> <span class="adv-cert-text">{{ $ctrl.currentElement.advancedVerification.fullName }}</span> <div class="cert-provider">{{ $ctrl.currentElement.advancedVerification.text }}</div> </div> <h2 class="product-name" ng-show="!$ctrl.isVideo"> F4/80 Antibody (17-4801-82) in Flow </h2> <div ng-show="!$ctrl.isVideo"> <div class="image-desc"> <div class="product-desc-text viewing-more-long-description"> <span class="image-journal-text" > </span> <span class="short-desc"> Staining of C57Bl/6 resident peritoneal exudate cells with Anti-Mouse CD11b PE (Product # 12-0112-82) and 1 µg of Rat IgG2a K Isotype Control APC (Product # 17-4321-81) (left) or 1 µg of Anti-Mouse F4/80 Antigen APC (right). 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Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented."> <?xml version="1.0" encoding="utf-8"?>  <svg version="1.1" id="Layer_1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 16 16" style="enable-background:new 0 0 16 16;" xml:space="preserve"> <style type="text/css"> .st0{fill-rule:evenodd;clip-rule:evenodd;fill:#A2A2A2;} </style> <g id="Log-In-_x2F_-Out-States"> <g id="_x31_200-00-AB-PDP-Logged-Out-Card" transform="translate(-953.000000, -1013.000000)"> <g id="icons_x2F_16_x2F_info_x2F_bold" transform="translate(952.000000, 1012.000000)"> <path id="Shape" class="st0" d="M9,4c2.8,0,5,2.2,5,5s-2.2,5-5,5s-5-2.2-5-5S6.2,4,9,4 M9,2C5.1,2,2,5.1,2,9s3.1,7,7,7s7-3.1,7-7 c0-1.9-0.7-3.6-2.1-4.9S10.9,2,9,2z M8,8.5v4.4h2V8.5H8z M8,5.2v2h2v-2H8z"/> </g> </g> </g> </svg> </span> </div> </div> <div ng-cloak ng-if="$ctrl.currentElement.benchSciPubmedId && $ctrl.currentElement.benchSciPubmedId != '0'" class="pubmed-link"> <span ng-class="$ctrl.getSeperatorClass()">PMID: <a target="_blank" href="http://pubmed.ncbi.nlm.nih.gov/pubmed/{{ $ctrl.currentElement.benchSciPubmedId }}">{{$ctrl.currentElement.benchSciPubmedId}}</a> </span> </div> </div> <div class="btn-view-product" ng-cloak ng-show="false"> <a role="button" class="btn img-view-product"> View Product </a> </div> </div> </div> <div ng-show="$ctrl.isVideo" class="video-desc hide"> <h2 class="product-name" ng-bind="$ctrl.videoTitle"></h2> <p>{{$ctrl.videoDesc}}</p> <p>{{$ctrl.videoLongDesc}}</p> </div> </div> </div> </div> <image-gallery-key-nav pdp-gallery="true"></image-gallery-key-nav> <div class="film-strip"> <div id="custom-scrollbar" class="set-of-images"> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="91132" data-index="0"> <img src="https://www.thermofisher.com/antibody/images/150/17-4801-82_F4-80_Flow_1-20170119083539.jpg?time=20240507" alt="F4/80 Antibody in Flow Cytometry (Flow)"/> </div> </div> </div> </div> </div> <noscript> <div itemscope itemtype="http://schema.org/ImageGallery"> <h2>Product Image Gallery</h2> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/17-4801-82_F4-80_Flow_1-20170119083539.jpg?time=20240507?time=20240507" alt="F4/80 Antibody in Flow Cytometry (Flow)" title="F4/80 Antibody (17-4801-82) in Flow"> <figcaption itemprop="caption">Staining of C57Bl/6 resident peritoneal exudate cells with Anti-Mouse CD11b PE (Product # 12-0112-82) and 1 µg of Rat IgG2a K Isotype Control APC (Product # 17-4321-81) (left) or 1 µg of Anti-Mouse F4/80 Antigen APC (right). Cells in the large scatter population were used for analysis.</figcaption> </figure> </div> </div> </noscript> <div id="tf-related-products-container-new"></div> <div class="product-details"> <div class="container"> <div class="row"> <div class="large-span-12 medium-span-12 small-span-12"> <h2 class="pdp-sub-heading product_details_heading">Product Details</h2></div> <div class="hidden-sku"> <h2>17-4801-82</h2> </div> <div class="product-detail-section tested-app-section new-tbl-design product-detail-section table-spec"> <div class="product-container-head"> <div class="product-item"> Applications </div> <div class="product-item dilution-lbl-head "> Tested Dilution </div> <div class="product-item published-applications"> Publications </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Immunohistochemistry (IHC)</h2></div> <div class="product-item "> <span class="dilution-lbl dilution-lbl-dash">-</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#IHC-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 2 publications</span> <span class="mobile-view">2 publications</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Immunohistochemistry (Paraffin) (IHC (P))</h2></div> <div class="product-item "> <span class="dilution-lbl dilution-lbl-dash">-</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#IHCP-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 2 publications</span> <span class="mobile-view">2 publications</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Immunohistochemistry (PFA fixed) (IHC (PFA))</h2></div> <div class="product-item "> <span class="dilution-lbl dilution-lbl-dash">-</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#IHCPFA-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 2 publications</span> <span class="mobile-view">2 publications</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Immunohistochemistry (Frozen) (IHC (F))</h2></div> <div class="product-item "> <span class="dilution-lbl dilution-lbl-dash">-</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#IHCF-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 2 publications</span> <span class="mobile-view">2 publications</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Immunocytochemistry (ICC/IF)</h2></div> <div class="product-item "> <span class="dilution-lbl dilution-lbl-dash">-</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#ICCIF-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 5 publications</span> <span class="mobile-view">5 publications</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Flow Cytometry (Flow)</h2></div> <div class="product-item "> <span class="dilution-lbl">2 µg/test</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#Flow-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 303 publications</span> <span class="mobile-view">303 publications</span></a> </div> </div> </div> <div class="product-detail-section tested-app-section new-tbl-design product-specific-section table-spec"> <div class="product-container-head"> <div class="product-item">Product Specifications</div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Species Reactivity</h2> </div> <div class="product-item left-flex-cls"> <span title="Mus musculus">Mouse</span> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Published species</h2> </div> <div class="product-item left-flex-cls"> <span>Human,</span> <span>Mouse</span> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2> Host/Isotype</h2> </div> <div class="product-item left-flex-cls"> <span title="Rattus">Rat / IgG2a, kappa</span> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Recommended Isotype Control</h2> </div> <div class="product-item left-flex-cls"> <a href="//www.thermofisher.com/antibody/product/17-4321-81"> Rat IgG2a kappa Isotype Control (eBR2a), APC, eBioscience™</a> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Class</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> Monoclonal </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Type</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> Antibody </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Clone</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> BM8 </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Conjugate</h2> </div> <div class="product-item left-flex-cls"> <a ng-if="$ctrl.checkConjugate('APC ') && '/us/en/home/life-science/cell-analysis/fluorophores/allophycocyanin.html?cid=bid_pca_aup_r01_co_cp1603_pjt0000_abs00000_0wm_tfs_il_crs_cs_s00_dye'.trim() != ''" href="/us/en/home/life-science/cell-analysis/fluorophores/allophycocyanin.html?cid=bid_pca_aup_r01_co_cp1603_pjt0000_abs00000_0wm_tfs_il_crs_cs_s00_dye" ng-attr-target="{{$ctrl.getRequestCustomLinkTarget()}}" class="conjugate-value">APC </a> <span ng-if="($ctrl.checkConjugate('APC ') && '/us/en/home/life-science/cell-analysis/fluorophores/allophycocyanin.html?cid=bid_pca_aup_r01_co_cp1603_pjt0000_abs00000_0wm_tfs_il_crs_cs_s00_dye'.trim() == '')" class="conjugate-value">APC </span> <span ng-if="!$ctrl.checkConjugate('APC ')" class="conjugate-value">APC </span> <div class="dropdown conjugate-dropdown"> <button class="btn-link conjugate-btn" type="button" data-toggle="dropdown"> View additional formats <span class="caret"></span> </button> <ul class="dropdown-menu dropdown-menu-fixed"> <li><a class="conjugate-color-padding" href="/antibody/product/14-4801-82"> Unconjugated <span class="conjugate-indicator" style="background-color:"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/53-4801-82"> Alexa Fluor 488 <span class="conjugate-indicator" style="background-color:#36FF00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/58-4801-82"> Alexa Fluor 532 <span class="conjugate-indicator" style="background-color:#B3FF00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/505-4801-82"> Alexa Fluor 561 <span class="conjugate-indicator" style="background-color:#E1FF00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/606-4801-82"> Alexa Fluor 660 <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/56-4801-82"> Alexa Fluor 700 <span class="conjugate-indicator" style="background-color:#8D0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/47-4801-82"> APC-eFluor 780 <span class="conjugate-indicator" style="background-color:#808080"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/13-4801-82"> Biotin <span class="conjugate-indicator" style="background-color:"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/363-4801-82"> Brilliant UV 395 <span class="conjugate-indicator" style="background-color:#8000A1"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/365-4801-82"> Brilliant UV 563 <span class="conjugate-indicator" style="background-color:#C3FF00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/376-4801-82"> Brilliant UV 661 <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/368-4801-82"> Brilliant UV 805 <span class="conjugate-indicator" style="background-color:#808080"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/404-4801-82"> Brilliant Violet 421 <span class="conjugate-indicator" style="background-color:#5400FF"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/416-4801-82"> Brilliant Violet 650 <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/407-4801-82"> Brilliant Violet 711 <span class="conjugate-indicator" style="background-color:#820000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/48-4801-82"> eFluor 450 <span class="conjugate-indicator" style="background-color:#0028FF"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/69-4801-82"> eFluor 506 <span class="conjugate-indicator" style="background-color:#00FF54"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/41-4801-82"> eFluor 570 <span class="conjugate-indicator" style="background-color:#E1FF00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/50-4801-82"> eFluor 660 <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/11-4801-82"> FITC <span class="conjugate-indicator" style="background-color:#1FFF00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/16-4801-86"> Functional Grade <span class="conjugate-indicator" style="background-color:"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/12-4801-82"> PE <span class="conjugate-indicator" style="background-color:#F0FF00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/15-4801-82"> PE-Cyanine5 <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/25-4801-82"> PE-Cyanine7 <span class="conjugate-indicator" style="background-color:#808080"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/61-4801-82"> PE-eFluor 610 <span class="conjugate-indicator" style="background-color:#FF9B00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/45-4801-82"> PerCP-Cyanine5.5 <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/62-4801-82"> Super Bright 436 <span class="conjugate-indicator" style="background-color:#3D00FF"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/63-4801-82"> Super Bright 600 <span class="conjugate-indicator" style="background-color:#FFBE00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/64-4801-82"> Super Bright 645 <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/67-4801-82"> Super Bright 702 <span class="conjugate-indicator" style="background-color:#8D0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/78-4801-82"> Super Bright 780 <span class="conjugate-indicator" style="background-color:#808080"></span> </a></li> <li class="drop-down-link-ctnr"> <a class="conjugate-dropdown-link" href="/us/en/home/global/forms/antibody-conjugates-custom-form.html" ng-attr-target="$ctrl.getRequestCustomLinkTarget()">Request custom conjugation <svg class="svg-icon external-link-icon" ng-if="$ctrl.showExternalLinkIcon()"> <use href="#external-link"></use> </svg> </a> </li> </ul> </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Excitation/Emission Max</h2> </div> <div class="product-item left-flex-cls"> <span>651/660 nm</span> <a target="_blank" class="spectra-view" href="/order/fluorescence-spectraviewer?SID=srch-svtool&UID=803ph75"> <span class="view-spectra"> View spectra</span> <span class="spectra-view-icon "><img src="/order/genome-database/assets/img/spectra.png" alt="spectra"/></span> </a> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Form</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> Liquid </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Concentration</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> 0.2 mg/mL </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Purification</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> Affinity chromatography </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Storage buffer</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> PBS, pH 7.2 </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Contains</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> 0.09% sodium azide </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Storage conditions</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> 4° C, store in dark, DO NOT FREEZE! </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Shipping conditions</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> Ambient (domestic); Wet ice (international) </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"><h2>RRID <span id="rrid-tooltip" class="rrid-tooltip-icon" ng-include="'/order/genome-database/webapp/assets/core/img/svg/mono_tooltip.svg'" data-toggle="tooltip" ng-click="$ctrl.showRridTooltip()" close-tooltip="$ctrl.closeRridTooltip()" title="Research Resource Identifiers (#RRID) are ID numbers assigned to help researchers cite key resources in the biomedical literature to improve transparency of research methods."> </span></h2> </div> <div class="product-item left-flex-cls">AB_2784648</div> </div> </div> <div class="product-specific-details"> <div class="product-specific-details-tbl product-specific-add-border" > <div class="product-info-para"> <h4 class="product-info-para-heading"> Product Specific Information </h4> <p>Description: The BM8 monoclonal antibody reacts with mouse F4/80 antigen, an approximately 160 kDa surface receptor. It belongs to the EGF-TM7 family of proteins. As such it contains seven EGF-like domains on its extracellular N-terminus, seven transmembrane spanning sequences, and an intracellular C-terminal domain showing homology to other TM7 superfamily members. The F4/80 antigen is expressed by a majority of mature macrophages and is one of the best markers for this population of cells. However, other cell types, such as peritoneal eosinophils, Langerhans cells, and some other dendritic cell subtypes, have been reported to express this antigen as well. Expression of F4/80 commences during early myeloid development in vivo and can be upregulated on BM cells stimulated in vitro with M-CSF. Some populations of macrophages, especially in the lymphoid microenvironment, may be devoid of F4/80.<br /><br />Applications Reported: BM8 has been reported for use in flow cytometric analysis.<br /><br />Applications Tested: The BM8 antibody has been tested by flow cytometric analysis of mouse resident peritoneal exudate cells. This can be used at less than or equal to 2 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.<br /><br />Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser.<br /><br />Filtration: 0.2 µm post-manufacturing filtered.</p> </div> <div class="product-info-para"> <h4 class="product-info-para-heading"> Target Information </h4> <p class="product-specific-target-info">F4/80 antigen is a 160 kDa cell surface glycoprotein that is a member of the EGF TM7 family of proteins and shares 68% overall amino acid identity with human EGF module containing mucin like hormone receptor 1 (EMR1). Expression of F4/80 is heterogeneous and is reported to vary during macrophage maturation and activation. The F4/80 antigen is expressed on a wide range of mature tissue macrophages including Kupffer cells, Langerhans, microglia, macrophages located in the gut lamina propria, peritoneal cavity, lung, thymus, bone marrow stroma and macrophages in the red pulp of the spleen. F4/80 expression has also been reported on a subpopulation of dendritic cells but is absent from macrophages located in T cell areas of the spleen and lymph node. The ligands and biological functions of the F4/80 antigen have not yet been determined but recent studies suggest a role for F4/80 in the generation of efferent CD8+ve regulatory T cells.</p> </div> <p class="product-details-regulatoryStmt">For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.</p> </div> <div class="product-detail-panel-builder"> <tf-promo-ad ng-if="$ctrl.showPromoAd" show-promo-ad="$ctrl.showPromoAd"></tf-promo-ad> <div class="product-detail-video"> <div tf-video-player-new video-id="6206990159001" player-width="368" player-height="210"></div> <div class="panel-builder"> <h4 class="product-info-para-heading"> How to use the Panel Builder </h4> <p>Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.</p> </div> </div> </div> </div> </div> </div> </div> <div id="rootPdpDocLoader"></div> <div id="tf-related-products-container" ng-show="emptyRelatedProductsWidget === false" > <related-products-container ng-if="showRelatedProductsWidget === true" base-url="'/api/magellan/related-products-ui/widget/v2/'" product-type="'antibody'" product-sub-type="'primary'" product-id="'17-4801-82'" country-code="'sg'" iso-language="'en'" > </related-products-container> </div> <div class="tf-pdp-divider" ng-if="emptyRelatedProductsWidget === false" ></div> <div class="references reference-section-2" id="references-component-id"> <div id="references-section-id"> <reference-section ng-if="loadReferences" default-display-card-limit="3" reference-count="316" sub-type="'Antibody'" application-data='{"citationApplications":[{"applicationAbbreviation":"IHC","citations":[{"title":"Involvement of TGF-β1/Smad3 Signaling in Carbon Tetrachloride-Induced Acute Liver Injury in Mice.","summary":"17-4801 was used in Immunofluorescence to study how the activation of TGF-β signaling contributes to the CCl4-induced acute liver injury.","authors":"Niu L,Cui X,Qi Y,Xie D,Wu Q,Chen X,Ge J,Liu Z","literatureId":"27224286","journal":"PloS one","volume":"11","publishedDate":"Jul 10, 2017, 4:00:00 AM","url":"http://dx.doi.org/10.1371/journal.pone.0156090","benchSci":false,"imageURL":"https://www.thermofisher.com/antibody/images/250/null?time\u003d20240507","journalAbbr":"PLoS One","sortOrder":148,"species":["Mouse"],"speciesDilutionMap":{"Mouse":"Not Cited"},"abbreviationToNameMap":{"IHC":"Immunohistochemistry"},"newSpeciesDilutionMap":{"Mouse~IHC~Not Cited":""}},{"title":"CRIPTO/GRP78 signaling maintains fetal and adult mammary stem cells ex vivo.","summary":"17-4801 was used in Immunofluorescence to identify the CRIPTO/GRP78 pathway as a developmentally conserved regulator of fetal and adult mammary stem cell behavior ex vivo.","authors":"Spike BT,Kelber JA,Booker E,Kalathur M,Rodewald R,Lipianskaya J,La J,He M,Wright T,Klemke R,Wahl GM,Gray PC","literatureId":"24749068","journal":"Stem cell reports","volume":"2","pageNumber":"427","publishedDate":"Apr 8, 2014, 4:00:00 AM","url":"http://dx.doi.org/10.1016/j.stemcr.2014.02.010","benchSci":false,"imageURL":"https://www.thermofisher.com/antibody/images/250/null?time\u003d20240507","journalAbbr":"Stem Cell Reports","sortOrder":188,"species":["Mouse"],"speciesDilutionMap":{"Mouse":"1:250"},"abbreviationToNameMap":{"IHC":"Immunohistochemistry"},"newSpeciesDilutionMap":{"Mouse~IHC~1:250":"1:250"}}],"citationsCount":2,"speciesList":["Mouse"],"journals":["Stem Cell Reports","PLoS One"],"speciesMap":{"Mouse":2},"journalsMap":{"Stem Cell Reports":1,"PLoS One":1},"sortedMap":{}},{"applicationAbbreviation":"IHC (P)","citations":[],"citationsCount":2,"speciesList":["Mouse"],"journals":["PLoS One","Cell Death Discov"],"speciesMap":{"Mouse":2},"journalsMap":{"PLoS One":1,"Cell Death Discov":1},"sortedMap":{}},{"applicationAbbreviation":"IHC (PFA)","citations":[],"citationsCount":2,"speciesList":["Mouse"],"journals":["Br J Cancer","Mucosal Immunol"],"speciesMap":{"Mouse":2},"journalsMap":{"Br J Cancer":1,"Mucosal Immunol":1},"sortedMap":{}},{"applicationAbbreviation":"IHC (F)","citations":[],"citationsCount":2,"speciesList":["Mouse"],"journals":["J Immunol","J Leukoc Biol"],"speciesMap":{"Mouse":1},"journalsMap":{"J Immunol":1,"J Leukoc Biol":1},"sortedMap":{}},{"applicationAbbreviation":"ICC/IF","citations":[],"citationsCount":5,"speciesList":["Mouse"],"journals":["Shock","PLoS One","J Exp Med","Proc Natl Acad Sci U S A","Adv Sci (Weinh)"],"speciesMap":{"Mouse":5},"journalsMap":{"Shock":1,"PLoS One":1,"J Exp Med":1,"Proc Natl Acad Sci U S A":1,"Adv Sci (Weinh)":1},"sortedMap":{}},{"applicationAbbreviation":"Flow","citations":[],"citationsCount":303,"speciesList":["Human","Mouse"],"journals":["Mol Med Rep","Cell Mol Biol Lett","Front Cell Neurosci","Nat Commun","Invest Ophthalmol Vis Sci","Biochem Biophys Res Commun","PLoS Comput Biol","Blood","J Cell Mol Med","EBioMedicine","Respir Res","Arterioscler Thromb Vasc Biol","Int J Cancer","Nat Cell Biol","Am J Pathol","J Am Heart Assoc","Mol Ther 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References</h2> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/37210553"> <div itemprop="name">Chronic psychological stress promotes breast cancer pre-metastatic niche formation by mobilizing splenic MDSCs via TAM/CXCL1 signaling.</div> </a> <div itemprop="about">Journal of experimental & clinical cancer research : CR</div> <div itemprop="author">Zheng Y,Wang N,Wang S,Zhang J,Yang B,Wang Z</div> <div itemprop="description">17-4801-82 was used in Flow cytometry/Cell sorting to investigate the impact of chronic psychological stress on breast cancer growth, metastasis, and pre-metastatic niche (PMN) formation.</div> <div itemprodp="datePublished">Sat May 20 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/37380764"> <div itemprop="name">GDF15 promotes weight loss by enhancing energy expenditure in muscle.</div> </a> <div itemprop="about">Nature</div> <div itemprop="author">Wang D,Townsend LK,DesOrmeaux GJ,Frangos SM,Batchuluun B,Dumont L,Kuhre RE,Ahmadi E,Hu S,Rebalka IA,Gautam J,Jabile MJT,Pileggi CA,Rehal S,Desjardins EM,Tsakiridis EE,Lally JSV,Juracic ES,Tupling AR,Gerstein HC,Paré G,Tsakiridis T,Harper ME,Hawke TJ,Speakman JR,Blondin DP,Holloway GP,Jørgensen SB,Steinberg GR</div> <div itemprop="description">17-4801-82 was used in Flow cytometry/Cell sorting to indicate that therapeutic targeting of the GDF15-GFRAL pathway may be useful for maintaining energy expenditure in skeletal muscle during caloric restriction.</div> <div itemprodp="datePublished">Sat Jul 01 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36165414"> <div itemprop="name">A plant-derived glucocorticoid receptor modulator with potency to attenuate the side effects of glucocorticoid therapy.</div> </a> <div itemprop="about">British journal of pharmacology</div> <div itemprop="author">Wang Y,Gao J,Yu Y,Zhou L,Wang M,Xue W,Liu B,Wu X,Wu X,Gao H,Shen Y,Xu Q</div> <div itemprop="description">17-4801-82 was used in flow cytometry to reveal that CA-e is a novel GR modulator with strong potency to attenuate the side effects of GC therapy and can be used as a potential molecular tool for deciphering GR signalling.</div> <div itemprodp="datePublished">Sun Jan 01 00:00:00 EST 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36658478"> <div itemprop="name">Photobiomodulation promotes spinal cord injury repair by inhibiting macrophage polarization through lncRNA TUG1-miR-1192/TLR3 axis.</div> </a> <div itemprop="about">Cellular & molecular biology letters</div> <div itemprop="author">Ju C,Ma Y,Zuo X,Wang X,Song Z,Zhang Z,Zhu Z,Li X,Liang Z,Ding T,Hu X,Wang Z</div> <div itemprop="description">17-4801-82 was used in Flow cytometry/Cell sorting to clarify that the lncRNA TUG1/miR-1192/TLR3 axis is an important pathway for PBM to inhibit M1 macrophage polarization and inflammation, which provides theoretical support for its clinical application in patients with SCI.</div> <div itemprodp="datePublished">Thu Jan 19 00:00:00 EST 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/37089435"> <div itemprop="name">Monocytes reprogrammed by tumor microparticle vaccine inhibit tumorigenesis and tumor development.</div> </a> <div itemprop="about">Cancer nanotechnology</div> <div itemprop="author">Sun W,Dai L,Cao Y,Pan P,Zhi L,Wang X,Yuan X,Gao Z,Guo S,Liu G,Yin J,Xie L,Wang L,Wang Y,Li W,Li H,Jia Y</div> <div itemprop="description">17-4801-82 was used in Flow cytometry/Cell sorting to provide novel vaccination strategy for the development of tumor vaccines and facilitate the application of T-MPs for clinic oncotherapy.</div> <div itemprodp="datePublished">Tue Apr 25 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36597089"> <div itemprop="name">Lactate oxidase/catalase-displaying nanoparticles efficiently consume lactate in the tumor microenvironment to effectively suppress tumor growth.</div> </a> <div itemprop="about">Journal of nanobiotechnology</div> <div itemprop="author">Choi H,Yeo M,Kang Y,Kim HJ,Park SG,Jang E,Park SH,Kim E,Kang S</div> <div itemprop="description">17-4801-82 was used in Flow cytometry/Cell sorting to show that the modular functionalization of protein nanoparticles with multiple metabolic enzymes may offer the opportunity to develop new enzyme complex-based therapeutic tools that can modulate the TME by controlling cancer metabolism.</div> <div itemprodp="datePublished">Tue Jan 03 00:00:00 EST 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35722379"> <div itemprop="name">G9a promotes inflammation in <i>Streptococcus pneumoniae</i> induced pneumonia mice by stimulating M1 macrophage polarization and H3K9me2 methylation in FOXP1 promoter region.</div> </a> <div itemprop="about">Annals of translational medicine</div> <div itemprop="author">Li Y,Li G,Zhang L,Li Y,Zhao Z</div> <div itemprop="description">17-4801-82 was used in Flow cytometry/Cell sorting to conclude that G9a promotes M1 polarization of macrophages by promoting H3K9me2 methylation in the FOXP1 promoter region, promoting an inflammatory response in Spn mice.</div> <div itemprodp="datePublished">Sun May 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35795081"> <div itemprop="name">Ionizable Lipid Nanoparticle-Mediated Delivery of Plasmid DNA in Cardiomyocytes.</div> </a> <div itemprop="about">International journal of nanomedicine</div> <div itemprop="author">Scalzo S,Santos AK,Ferreira HAS,Costa PA,Prazeres PHDM,da Silva NJA,Guimarães LC,E Silva MM,Rodrigues Alves MTR,Viana CTR,Jesus ICG,Rodrigues AP,Birbrair A,Lobo AO,Frezard F,Mitchell MJ,Guatimosim S,Guimaraes PPG</div> <div itemprop="description">17-4801-82 was used in Flow cytometry/Cell sorting to highlight the potential of LNPs as an efficient delivery vector for pDNA to cardiomyocytes.</div> <div itemprodp="datePublished">Fri Jul 08 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34774126"> <div itemprop="name">Systemic delivery of a targeted synthetic immunostimulant transforms the immune landscape for effective tumor regression.</div> </a> <div itemprop="about">Cell chemical biology</div> <div itemprop="author">Miller CL,Sagiv-Barfi I,Neuhöfer P,Czerwinski DK,Artandi SE,Bertozzi CR,Levy R,Cochran JR</div> <div itemprop="description">17-4801-82 was used in Flow cytometry/Cell sorting to demonstrate that conjugation to a synthetic tumor-targeted peptide can improve the efficacy of systemically administered immunostimulants and lead to durable anti-tumor immune responses.</div> <div itemprodp="datePublished">Thu Mar 17 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34791825"> <div itemprop="name">Smad3 Promotes Cancer-Associated Fibroblasts Generation via Macrophage-Myofibroblast Transition.</div> </a> <div itemprop="about">Advanced science (Weinheim, Baden-Wurttemberg, Germany)</div> <div itemprop="author">Tang PC,Chung JY,Xue VW,Xiao J,Meng XM,Huang XR,Zhou S,Chan AS,Tsang AC,Cheng AS,Lee TL,Leung KT,Lam EW,To KF,Tang PM,Lan HY</div> <div itemprop="description">17-4801-82 was used in Immunocytochemistry-immunoflourescence to conclude that MMT may represent a novel therapeutic target of CAF for cancer immunotherapy.</div> <div itemprodp="datePublished">Sat Jan 01 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35870427"> <div itemprop="name">Therapeutic effect of NLRP3 inhibition on hearing loss induced by systemic inflammation in a CAPS-associated mouse model.</div> </a> <div itemprop="about">EBioMedicine</div> <div itemprop="author">Ma JH,Lee E,Yoon SH,Min H,Oh JH,Hwang I,Sung Y,Ryu JH,Bok J,Yu JW</div> <div itemprop="description">17-4801-82 was used in Flow cytometry/Cell sorting to investigate whether Cryopyrin-associated periodic syndrome-associated mutation in NLRP3 is associated with the progression of hearing loss.</div> <div itemprodp="datePublished">Mon Aug 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35371065"> <div itemprop="name">Photobiomodulation Attenuates Neurotoxic Polarization of Macrophages by Inhibiting the Notch1-HIF-1α/NF-κB Signalling Pathway in Mice With Spinal Cord Injury.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Ma Y,Li P,Ju C,Zuo X,Li X,Ding T,Liang Z,Zhang J,Li K,Wang X,Zhu Z,Zhang Z,Song Z,Quan H,Hu X,Wang Z</div> <div itemprop="description">17-4801-82 was used in Flow cytometry/Cell sorting to investigate spinal chord injury treatment with photobiomodulation of macrophages.</div> <div itemprodp="datePublished">Fri Apr 08 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35496904"> <div itemprop="name">The Time Course of Monocytes Infiltration After Acoustic Overstimulation.</div> </a> <div itemprop="about">Frontiers in cellular neuroscience</div> <div itemprop="author">Shin SH,Jung J,Park HR,Sim NS,Choi JY,Bae SH</div> <div itemprop="description">17-4801-82 was used in Flow cytometry/Cell sorting to investigate time-dependent immune cell infiltration, macrophage transformation, and neutrophil involvement following acoustic stimulation.</div> <div itemprodp="datePublished">Sat Jul 16 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36387896"> <div itemprop="name">Grim-19 deficiency promotes decidual macrophage autophagy in recurrent spontaneous abortion.</div> </a> <div itemprop="about">Frontiers in endocrinology</div> <div itemprop="author">Yang Y,Liu H,Zhao Y,Geng C,Chao L,Hao A</div> <div itemprop="description">17-4801-82 was used in Flow cytometry/Cell sorting to reveal that Grim-19 deficiency influences macrophage function, characterized by enhanced proinflammatory cytokines and phagocytic activity, and this might be regulated by autophagy.</div> <div itemprodp="datePublished">Tue Nov 22 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35328324"> <div itemprop="name">Bladder Cancer Extracellular Vesicles Elicit a CD8 T Cell-Mediated Antitumor Immunity.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Ortiz-Bonilla CJ,Uccello TP,Gerber SA,Lord EM,Messing EM,Lee YF</div> <div itemprop="description">17-4801-82 was used in Flow cytometry/Cell sorting to support the potential application of TEVs in personalized medicine, and open new avenues for the development of adjuvant therapies based on patient-derived EVs aimed at preventing disease progression.</div> <div itemprodp="datePublished">Tue Mar 08 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35681481"> <div itemprop="name">CD200R1 Contributes to Successful Functional Reinnervation after a Sciatic Nerve Injury.</div> </a> <div itemprop="about">Cells</div> <div itemprop="author">Pannunzio B,Amo-Aparicio J,Julián C,López-Vales R,Peluffo H,Lago N</div> <div itemprop="description">17-4801-82 was used in Flow cytometry/Cell sorting to show that CD200R1 has a role in mounting a successful acute inflammatory reaction after injury, and contributes to an effective functional recovery.</div> <div itemprodp="datePublished">Mon May 30 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32746697"> <div itemprop="name">HFE inhibits type I IFNs signaling by targeting the SQSTM1-mediated MAVS autophagic degradation.</div> </a> <div itemprop="about">Autophagy</div> <div itemprop="author">Liu J,Wu X,Wang H,Wei J,Wu Q,Wang X,Yan Y,Cui J,Min J,Wang F,Zhou J</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to identify 5 iron metabolism-associated genes specifically affected during RNA virus infection by a high-throughput assay and further found that HFE was a key negative regulator of RIG-I-like receptors (RLR)-mediated type I interferons (IFNs) signaling.</div> <div itemprodp="datePublished">Sun Aug 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33929610"> <div itemprop="name">Ablation of lysozyme M-positive cells prevents aircraft noise-induced vascular damage without improving cerebral side effects.</div> </a> <div itemprop="about">Basic research in cardiology</div> <div itemprop="author">Frenis K,Helmstädter J,Ruan Y,Schramm E,Kalinovic S,Kröller-Schön S,Bayo Jimenez MT,Hahad O,Oelze M,Jiang S,Wenzel P,Sommer CJ,Frauenknecht KBM,Waisman A,Gericke A,Daiber A,Münzel T,Steven S</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to determine the role of myeloid cells in the vascular vs. cerebral consequences of exposure to aircraft noise.</div> <div itemprodp="datePublished">Fri Apr 30 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33247999"> <div itemprop="name">Interleukin 6 regulates the expression of programmed cell death ligand 1 in thyroid cancer.</div> </a> <div itemprop="about">Cancer science</div> <div itemprop="author">Zhang GQ,Jiao Q,Shen CT,Song HJ,Zhang HZ,Qiu ZL,Luo QY</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate the expression of IL-6 and PD-L1 in thyroid cancer, and whether IL-6 regulates the PD-L1 expression.</div> <div itemprodp="datePublished">Mon Mar 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34092215"> <div itemprop="name">CD36 deficiency ameliorates drug-induced acute liver injury in mice.</div> </a> <div itemprop="about">Molecular medicine (Cambridge, Mass.)</div> <div itemprop="author">Zhang C,Shi X,Su Z,Hu C,Mu X,Pan J,Li M,Teng F,Ling T,Zhao T,Xu C,Ji G,You Q</div> <div itemprop="description">17-4801-82 was used in Flow Cytometry to demonstrate that CD36 deficiency ameliorated APAP-induced acute liver injury and inflammatory responses by decreasing JNK activation.</div> <div itemprodp="datePublished">Sun Jun 06 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33124186"> <div itemprop="name">Transient activation of tumoral DNA damage tolerance pathway coupled with immune checkpoint blockade exerts durable tumor regression in mouse melanoma.</div> </a> <div itemprop="about">Pigment cell & melanoma research</div> <div itemprop="author">Zhuo M,Gorgun FM,Tyler DS,Englander EW</div> <div itemprop="description">17-4801-82 was used in Flow cytometry/Cell sorting to expect that this new combination protocol affords insights with clinical relevance that will help expand the range of patients who benefit from ICB therapy.</div> <div itemprodp="datePublished">Sat May 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34017248"> <div itemprop="name">MiR-19a-3p Suppresses M1 Macrophage Polarization by Inhibiting STAT1/IRF1 Pathway.</div> </a> <div itemprop="about">Frontiers in pharmacology</div> <div itemprop="author">Zhu X,Guo Q,Zou J,Wang B,Zhang Z,Wei R,Zhao L,Zhang Y,Chu C,Fu X,Li X</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to confirm that miR-19a-3p, as a direct regulator of STAT1, inhibited M1 macrophages polarization.</div> <div itemprodp="datePublished">Sun May 23 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34127647"> <div itemprop="name">Gasdermin D in peripheral nerves: the pyroptotic microenvironment inhibits nerve regeneration.</div> </a> <div itemprop="about">Cell death discovery</div> <div itemprop="author">Tao Y,Wang F,Xu Z,Lu X,Yang Y,Wu J,Yao C,Yi F,Li J,Huang Z,Liu Y</div> <div itemprop="description">17-4801-82 was used in Immunohistochemistry (Paraffin) to study the involvement of foamy cells in peripheral nerve regeneration in a GSDMD-/- mouse model.</div> <div itemprodp="datePublished">Mon Jun 14 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34127647"> <div itemprop="name">Gasdermin D in peripheral nerves: the pyroptotic microenvironment inhibits nerve regeneration.</div> </a> <div itemprop="about">Cell death discovery</div> <div itemprop="author">Tao Y,Wang F,Xu Z,Lu X,Yang Y,Wu J,Yao C,Yi F,Li J,Huang Z,Liu Y</div> <div itemprop="description">17-4801-82 was used in Immunohistochemistry (Paraffin) to study the involvement of foamy cells in peripheral nerve regeneration in a GSDMD-/- mouse model.</div> <div itemprodp="datePublished">Mon Jun 14 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34750342"> <div itemprop="name">CD5L deficiency attenuate acetaminophen-induced liver damage in mice via regulation of JNK and ERK signaling pathway.</div> </a> <div itemprop="about">Cell death discovery</div> <div itemprop="author">Li M,Ling T,Teng F,Hu C,Su Z,Zhang C,Li X,Zhao T,Mu X,Li Y,Pan J,You Q</div> <div itemprop="description">17-4801-82 was used in Flow Cytometry to reveal that CD5L may be a potential therapeutic target for prevention and treatment of APAP-induced liver injury.</div> <div itemprodp="datePublished">Mon Nov 08 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34072973"> <div itemprop="name">Effects of Dietary Protein Intake on Cutaneous and Systemic Inflammation in Mice with Acute Experimental Psoriasis.</div> </a> <div itemprop="about">Nutrients</div> <div itemprop="author">Knopp T,Bieler T,Jung R,Ringen J,Molitor M,Jurda A,Münzel T,Waisman A,Wenzel P,Karbach SH,Wild J</div> <div itemprop="description">17-4801-82 was used in Flow Cytometry to study the influence of dietary protein on psoriasis-like skin disease in mice.</div> <div itemprodp="datePublished">Mon May 31 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33754355"> <div itemprop="name">Innate and adaptive immune responses following PD-L1 blockade in treating chronic murine alveolar echinococcosis.</div> </a> <div itemprop="about">Parasite immunology</div> <div itemprop="author">Jebbawi F,Bellanger AP,Lunström-Stadelmann B,Rufener R,Dosch M,Goepfert C,Gottstein B,Millon L,Grandgirard D,Leib SL,Beldi G,Wang J</div> <div itemprop="description">17-4801-82 was used in Flow cytometry/Cell sorting to suggest that the PD-L1 pathway plays an important role by regulating adaptive and innate immune cells against E. multilocularis infection, with significant modulation of tissue inflammation.</div> <div itemprodp="datePublished">Sun Aug 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33993198"> <div itemprop="name">BMI1 regulates multiple myeloma-associated macrophage's pro-myeloma functions.</div> </a> <div itemprop="about">Cell death & disease</div> <div itemprop="author">Zhang D,Huang J,Wang F,Ding H,Cui Y,Yang Y,Xu J,Luo H,Gao Y,Pan L,Wu Y,Gong Y,Xie L,Liu Z,Qu Y,Zhang L,Liu W,Zhang W,Zhao S,Yi Q,Niu T,Zheng Y</div> <div itemprop="description">17-4801-82 was used in Flow Cytometry to demonstrate the role of the polycomb-group protein, BMI1, in the modulation of pro-myeloma macrophages.</div> <div itemprodp="datePublished">Sat May 15 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33991461"> <div itemprop="name">Prevention of non-alcoholic steatohepatitis by long-term exercise via the induction of phenotypic changes in Kupffer cells of hyperphagic obese mice.</div> </a> <div itemprop="about">Physiological reports</div> <div itemprop="author">Miura I,Komine S,Okada K,Wada S,Warabi E,Uchida F,Oh S,Suzuki H,Mizokami Y,Shoda J</div> <div itemprop="description">17-4801-82 was used in Flow cytometry/Cell sorting to suggest a molecular mechanism for the beneficial effect of exercise in the management of patients with nonalcoholic fatty liver disease.</div> <div itemprodp="datePublished">Sat May 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34001860"> <div itemprop="name">DA-DRD5 signaling controls colitis by regulating colonic M1/M2 macrophage polarization.</div> </a> <div itemprop="about">Cell death & disease</div> <div itemprop="author">Liu L,Wu Y,Wang B,Jiang Y,Lin L,Li X,Yang S</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to provide demonstration of DA-DRD5 signaling in colonic macrophages controlling the development of colitis by regulating M1/M2 macrophage polarization.</div> <div itemprodp="datePublished">Mon May 17 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33378651"> <div itemprop="name">Resident and elicited murine macrophages differ in expression of their glycomes and glycan-binding proteins.</div> </a> <div itemprop="about">Cell chemical biology</div> <div itemprop="author">Park DD,Chen J,Kudelka MR,Jia N,Haller CA,Kosaraju R,Premji AM,Galizzi M,Nairn AV,Moremen KW,Cummings RD,Chaikof EL</div> <div itemprop="description">17-4801-82 was used in Flow Cytometry to study the features of glycosylation that are associated with macrophage lineage and polarization in mice.</div> <div itemprodp="datePublished">Thu Apr 15 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34518510"> <div itemprop="name">Mesenchymal stem cells attenuate liver fibrosis by targeting Ly6C<sup>hi/lo</sup> macrophages through activating the cytokine-paracrine and apoptotic pathways.</div> </a> <div itemprop="about">Cell death discovery</div> <div itemprop="author">Li YH,Shen S,Shao T,Jin MT,Fan DD,Lin AF,Xiang LX,Shao JZ</div> <div itemprop="description">17-4801-82 was used in Flow Cytometry to provide insights into the functional role of bone marrow-derived sesenchymal stem cell in alleviating liver fibrosis.</div> <div itemprodp="datePublished">Mon Sep 13 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34296202"> <div itemprop="name">Intestinal barrier dysfunction plays an integral role in arthritis pathology and can be targeted to ameliorate disease.</div> </a> <div itemprop="about">Med (New York, N.Y.)</div> <div itemprop="author">Matei DE,Menon M,Alber DG,Smith AM,Nedjat-Shokouhi B,Fasano A,Magill L,Duhlin A,Bitoun S,Gleizes A,Hacein-Bey-Abina S,Manson JJ,Rosser EC,Klein N,Blair PA,Mauri C</div> <div itemprop="description">17-4801-82 was used in Flow Cytometry to analyze changes in markers of gut permeability, damage, and inflammation in peripheral blood and serum of rheumatoid arthritis patients, as well as relevant organs in engineered arthritic mice.</div> <div itemprodp="datePublished">Fri Jul 09 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33482848"> <div itemprop="name">Chronic exposure to IL-6 induces a desensitized phenotype of the microglia.</div> </a> <div itemprop="about">Journal of neuroinflammation</div> <div itemprop="author">Recasens M,Almolda B,Pérez-Clausell J,Campbell IL,González B,Castellano B</div> <div itemprop="description">17-4801-82 was used in Flow Cytometry to evaluate the effects of chronic IL-6 production on the immune response associated with CNS-axonal anterograde degeneration.</div> <div itemprodp="datePublished">Fri Jan 22 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34462312"> <div itemprop="name">Radiation-Induced Macrophage Senescence Impairs Resolution Programs and Drives Cardiovascular Inflammation.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Sadhu S,Decker C,Sansbury BE,Marinello M,Seyfried A,Howard J,Mori M,Hosseini Z,Arunachalam T,Finn AV,Lamar JM,Jourd'heuil D,Guo L,MacNamara KC,Spite M,Fredman G</div> <div itemprop="description">17-4801-82 was used in Flow cytometry/Cell sorting to demonstrate that sublethal radiation drives macrophage senescence and efferocytosis defects and suggest that RvD1 may be a new therapeutic strategy to limit radiation-induced tissue damage.</div> <div itemprodp="datePublished">Fri Oct 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34184323"> <div itemprop="name">Sustained calcium ion release from bioceramics promotes CaSR-mediated M2 macrophage polarization for osteoinduction.</div> </a> <div itemprop="about">Journal of leukocyte biology</div> <div itemprop="author">Zhang J,Wu Q,Yin C,Jia X,Zhao Z,Zhang X,Yuan G,Hu H,Zhao Q</div> <div itemprop="description">17-4801-82 was used in Flow cytometry/Cell sorting to underscore the critical role of macrophages in bone regeneration and clarify the molecular mechanisms of Ca2+ -mediated osteoinduction by biomaterials, which is of great significance for the future design of biomaterial-oriented tissue regeneration engineering.</div> <div itemprodp="datePublished">Wed Sep 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32673566"> <div itemprop="name">The Cytokine TGF-β Induces Interleukin-31 Expression from Dermal Dendritic Cells to Activate Sensory Neurons and Stimulate Wound Itching.</div> </a> <div itemprop="about">Immunity</div> <div itemprop="author">Xu J,Zanvit P,Hu L,Tseng PY,Liu N,Wang F,Liu O,Zhang D,Jin W,Guo N,Han Y,Yin J,Cain A,Hoon MA,Wang S,Chen W</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate the mechanisms underlying itching associated with cutaneous wound healing, focusing on the contribution of soluble factors released during healing.</div> <div itemprodp="datePublished">Tue Aug 18 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32707077"> <div itemprop="name">Emergence of a High-Plasticity Cell State during Lung Cancer Evolution.</div> </a> <div itemprop="about">Cancer cell</div> <div itemprop="author">Marjanovic ND,Hofree M,Chan JE,Canner D,Wu K,Trakala M,Hartmann GG,Smith OC,Kim JY,Evans KV,Hudson A,Ashenberg O,Porter CBM,Bejnood A,Subramanian A,Pitter K,Yan Y,Delorey T,Phillips DR,Shah N,Chaudhary O,Tsankov A,Hollmann T,Rekhtman N,Massion PP,Poirier JT,Mazutis L,Li R,Lee JH,Amon A,Rudin CM,Jacks T,Regev A,Tammela T</div> <div itemprop="description">17-4801-82 was used in Flow Cytometry to profile cellular transcriptomes of lung tumours at different stages.</div> <div itemprodp="datePublished">Mon Aug 10 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34138183"> <div itemprop="name">Dual-Wavelength Photosensitive Nano-in-Micro Scaffold Regulates Innate and Adaptive Immune Responses for Osteogenesis.</div> </a> <div itemprop="about">Nano-micro letters</div> <div itemprop="author">Zhao Q,Shi M,Yin C,Zhao Z,Zhang J,Wang J,Shen K,Zhang L,Tang H,Xiao Y,Zhang Y</div> <div itemprop="description">17-4801-82 was used in Flow Cytometry to demonstrate that biomaterials developed to have specific regulatory capacities for immune cells can be used to control the early inflammatory responses of implanted materials and induce osteogenesis.</div> <div itemprodp="datePublished">Sat Nov 21 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32197069"> <div itemprop="name">Potently Cytotoxic Natural Killer Cells Initially Emerge from Erythro-Myeloid Progenitors during Mammalian Development.</div> </a> <div itemprop="about">Developmental cell</div> <div itemprop="author">Dege C,Fegan KH,Creamer JP,Berrien-Elliott MM,Luff SA,Kim D,Wagner JA,Kingsley PD,McGrath KE,Fehniger TA,Palis J,Sturgeon CM</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to identify an extra-embryonic origin of potently cytotoxic NK cells, suggesting that ontogenic origin is a relevant factor in designing hPSC-derived adoptive immunotherapies.</div> <div itemprodp="datePublished">Mon Apr 20 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32133635"> <div itemprop="name">Critical role of OX40 in drug-induced acute liver injury.</div> </a> <div itemprop="about">British journal of pharmacology</div> <div itemprop="author">Zhang C,Jin H,Wang Y,Li C,Zhao X,Li Y,Shi W,Tian Y,Xu H,Tian D,Liu K,Jia J,Sun G,Zhang D</div> <div itemprop="description">17-4801-82 was used in Flow Cytometry to show that OX40 is a key molecule that promotes both pro-inflammatory macrophage and CD4+ T-cell function, exacerbating paracetamol-induced liver injury.</div> <div itemprodp="datePublished">Wed Jul 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32112048"> <div itemprop="name">Spatial proteomics revealed a CX<sub>3</sub>CL1-dependent crosstalk between the urothelium and relocated macrophages through IL-6 during an acute bacterial infection in the urinary bladder.</div> </a> <div itemprop="about">Mucosal immunology</div> <div itemprop="author">Bottek J,Soun C,Lill JK,Dixit A,Thiebes S,Beerlage AL,Horstmann M,Urbanek A,Heuer H,Uszkoreit J,Eisenacher M,Bracht T,Sitek B,Hoffmann F,Vijitha N,von Eggeling F,Engel DR</div> <div itemprop="description">17-4801-82 was used in Immunohistochemistry (PFA fixed) to describe the crosstalk between the infected urothelium and macrophages through IL-6-induced CX3CL1 expression.</div> <div itemprodp="datePublished">Wed Jul 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32311768"> <div itemprop="name">M2 polarization of tumor-associated macrophages is dependent on integrin β3 via peroxisome proliferator-activated receptor-γ up-regulation in breast cancer.</div> </a> <div itemprop="about">Immunology</div> <div itemprop="author">Shu Y,Qin M,Song Y,Tang Q,Huang Y,Shen P,Lu Y</div> <div itemprop="description">17-4801-82 was used in Flow Cytometry to find a connection between integrin β3 and macrophage polarization.</div> <div itemprodp="datePublished">Sat Aug 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31941672"> <div itemprop="name">Deficiency in ZMPSTE24 and resulting farnesyl-prelamin A accumulation only modestly affect mouse adipose tissue stores.</div> </a> <div itemprop="about">Journal of lipid research</div> <div itemprop="author">Heizer PJ,Yang Y,Tu Y,Kim PH,Chen NY,Hu Y,Yoshinaga Y,de Jong PJ,Vergnes L,Morales JE,Li RL,Jackson N,Reue K,Young SG,Fong LG</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to generate a conditional knockout Zmpste24 allele and use it to create adipocyte-specific Zmpste24-knockout mice.</div> <div itemprodp="datePublished">Sun Mar 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32468025"> <div itemprop="name">Ribonuclease T2 from Aspergillus fumigatus promotes T helper type 2 responses through M2 polarization of macrophages.</div> </a> <div itemprop="about">International journal of molecular medicine</div> <div itemprop="author">Chen JJ,He YS,Zhong XJ,Cai ZL,Lyu YS,Zhao ZF,Ji K</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to reveal that high rAf RNASET2 activity is required for rAf RNASET2‚induced M2 polarization of macrophages.</div> <div itemprodp="datePublished">Sat Aug 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32965772"> <div itemprop="name">Mesenchymal stem cell-secreted extracellular vesicles carrying TGF-β1 up-regulate miR-132 and promote mouse M2 macrophage polarization.</div> </a> <div itemprop="about">Journal of cellular and molecular medicine</div> <div itemprop="author">Wang Y,Han B,Wang Y,Wang C,Zhang H,Xue J,Wang X,Niu T,Niu Z,Chen Y</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to provide evidence reporting that MSC-secreted EVs carry TGF-β1 to promote M2 polarization of macrophages via modulation of the miR-132/Mycbp2/TSC2 axis.</div> <div itemprodp="datePublished">Sun Nov 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32326670"> <div itemprop="name">Interleukin-9 Inhibits Lung Metastasis of Melanoma through Stimulating Anti-Tumor M1 Macrophages.</div> </a> <div itemprop="about">Molecules and cells</div> <div itemprop="author">Park SM,Do-Thi VA,Lee JO,Lee H,Kim YS</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to demonstrate that IL-9 can induce an anti-metastasis effect by enhancing the polarization and proliferation of M1 macrophages.</div> <div itemprodp="datePublished">Sun May 31 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32319653"> <div itemprop="name">Immunotherapy of Bacillus Calmette‑Guérin by targeting macrophages against bladder cancer in a NOD/scid IL2Rg‑/‑ mouse model.</div> </a> <div itemprop="about">Molecular medicine reports</div> <div itemprop="author">Tan QL,Zhou CY,Cheng L,Luo M,Liu CP,Xu WX,Zhang X,Zeng X</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate the role and potential mechanism of Bacillus Calmette-Guérin (BCG) immunotherapy for bladder cancer (BCa).</div> <div itemprodp="datePublished">Wed Jul 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32014257"> <div itemprop="name">A mouse model of humanized liver shows a human-like lipid profile, but does not form atherosclerotic plaque after western type diet.</div> </a> <div itemprop="about">Biochemical and biophysical research communications</div> <div itemprop="author">Sari G,Meester EJ,van der Zee LC,Wouters K,van Lennep JR,Peppelenbosch M,Boonstra A,Van der Heiden K,Mulder MMT,Vanwolleghem T</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to examine the suitability of mice with a humanized liver as a model for lipoprotein studies and studies on plaque formation, given the central role of hepatocytes in lipoprotein synthesis and metabolism.</div> <div itemprodp="datePublished">Thu Apr 02 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32294445"> <div itemprop="name">Immunotherapeutic Blockade of CD47 Inhibitory Signaling Enhances Innate and Adaptive Immune Responses to Viral Infection.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Cham LB,Torrez Dulgeroff LB,Tal MC,Adomati T,Li F,Bhat H,Huang A,Lang PA,Moreno ME,Rivera JM,Galkina SA,Kosikova G,Stoddart CA,McCune JM,Myers LM,Weissman IL,Lang KS,Hasenkrug KJ</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to indicate that CD47 blockade not only enhances the function of innate immune cells but also links to adaptive immune responses through improved APC function.</div> <div itemprodp="datePublished">Tue Apr 14 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32720575"> <div itemprop="name">Macrophage NCOR1 Deficiency Ameliorates Myocardial Infarction and Neointimal Hyperplasia in Mice.</div> </a> <div itemprop="about">Journal of the American Heart Association</div> <div itemprop="author">Du LJ,Sun JY,Zhang WC,Wang YL,Zhu H,Liu T,Gao MZ,Zheng C,Zhang YY,Liu Y,Liu Y,Shao S,Zhang XQ,Leng Q,Auwerx J,Duan SZ</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to demonstrate that NCOR1 is a critical regulator of macrophage inflammation and proliferation and that deficiency of NCOR1 in macrophages attenuates MI and neointimal hyperplasia.</div> <div itemprodp="datePublished">Tue Aug 04 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32549769"> <div itemprop="name">MiR-103 protects from recurrent spontaneous abortion via inhibiting STAT1 mediated M1 macrophage polarization.</div> </a> <div itemprop="about">International journal of biological sciences</div> <div itemprop="author">Zhu X,Liu H,Zhang Z,Wei R,Zhou X,Wang Z,Zhao L,Guo Q,Zhang Y,Chu C,Wang L,Li X</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to prove decreased miR-103 is involved in RSA by increasing M1 macrophage polarization via promoting STAT1/IRF1 signaling pathway. miR-103 may be explored as a promising diagnostic marker and therapeutic target for RSA.</div> <div itemprodp="datePublished">Fri Nov 12 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33298044"> <div itemprop="name">4-Hydroxyisoleucine relieves inflammation through iRhom2-dependent pathway in co-cultured macrophages and adipocytes with LPS stimulation.</div> </a> <div itemprop="about">BMC complementary medicine and therapies</div> <div itemprop="author">Zhou C,Chen R,Gao F,Zhang J,Lu F</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate the effects and mechanisms of 4-HIL on obesity-induced inflammation in RAW264.7 macrophages and 3 T3-L1 adipocytes co-culture system.</div> <div itemprodp="datePublished">Wed Dec 09 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31968250"> <div itemprop="name">Vitamin D Receptor Controls Cell Stemness in Acute Myeloid Leukemia and in Normal Bone Marrow.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Paubelle E,Zylbersztejn F,Maciel TT,Carvalho C,Mupo A,Cheok M,Lieben L,Sujobert P,Decroocq J,Yokoyama A,Asnafi V,Macintyre E,Tamburini J,Bardet V,Castaigne S,Preudhomme C,Dombret H,Carmeliet G,Bouscary D,Ginzburg YZ,de Thé H,Benhamou M,Monteiro RC,Vassiliou GS,Hermine O,Moura IC</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to present an unexpected role of VDR in normal hematopoiesis and in leukemogenesis.</div> <div itemprodp="datePublished">Tue Jan 21 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32373213"> <div itemprop="name">PTPROt aggravates inflammation by enhancing NF-κB activation in liver macrophages during nonalcoholic steatohepatitis.</div> </a> <div itemprop="about">Theranostics</div> <div itemprop="author">Jin K,Liu Y,Shi Y,Zhang H,Sun Y,Zhangyuan G,Wang F,Yu W,Wang J,Tao X,Chen X,Zhang W,Sun B</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to indicate that PTPROt plays a dual role in inflammation via the NF-κB signaling pathway in liver macrophages during NASH.</div> <div itemprodp="datePublished">Mon Jul 26 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32671214"> <div itemprop="name">Gasdermin D in macrophages restrains colitis by controlling cGAS-mediated inflammation.</div> </a> <div itemprop="about">Science advances</div> <div itemprop="author">Ma C,Yang D,Wang B,Wu C,Wu Y,Li S,Liu X,Lassen K,Dai L,Yang S</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to provide the first demonstration of GSDMD's role in controlling colitis and a detailed delineation of the underlying mechanism.</div> <div itemprodp="datePublished">Fri May 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32695095"> <div itemprop="name">Macrophage Sphingosine 1-Phosphate Receptor 2 Blockade Attenuates Liver Inflammation and Fibrogenesis Triggered by NLRP3 Inflammasome.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Hou L,Yang L,Chang N,Zhao X,Zhou X,Dong C,Liu F,Yang L,Li L</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to show that targeting macrophage S1PR2 retarded liver inflammation and fibrogenesis via downregulating NLRP3 inflammasome.</div> <div itemprodp="datePublished">Thu Apr 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33150865"> <div itemprop="name">MicroRNAs of the miR-17~9 family maintain adipose tissue macrophage homeostasis by sustaining IL-10 expression.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Zhang X,Liu J,Wu L,Hu X</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to identifiy miR-17~92 family miRNAs as crucial regulators of the balance between pro- and anti-inflammatory cytokines and exemplify how macrophage-intrinsic regulatory circuit exerted impactful influence on general physiology.</div> <div itemprodp="datePublished">Thu Nov 05 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32846136"> <div itemprop="name">Mitofusin 2 in Macrophages Links Mitochondrial ROS Production, Cytokine Release, Phagocytosis, Autophagy, and Bactericidal Activity.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Tur J,Pereira-Lopes S,Vico T,Marín EA,Muñoz JP,Hernández-Alvarez M,Cardona PJ,Zorzano A,Lloberas J,Celada A</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to reveal an unexpected contribution of Mfn2 to ROS production and inflammation in macrophages.</div> <div itemprodp="datePublished">Tue Aug 25 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33208556"> <div itemprop="name">Hyaluronan control of the primary vascular barrier during early mouse pregnancy is mediated by uterine NK cells.</div> </a> <div itemprop="about">JCI insight</div> <div itemprop="author">Hadas R,Gershon E,Cohen A,Atrakchi O,Lazar S,Golani O,Dassa B,Elbaz M,Cohen G,Eilam R,Dekel N,Neeman M</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to demonstrate a pivotal role for hyaluronan in successful pregnancy by fine-tuning the periembryo avascular niche and maternal vascular morphogenesis.</div> <div itemprodp="datePublished">Thu Nov 19 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33154149"> <div itemprop="name">Nicotinamide combined with gemcitabine is an immunomodulatory therapy that restrains pancreatic cancer in mice.</div> </a> <div itemprop="about">Journal for immunotherapy of cancer</div> <div itemprop="author">Selvanesan BC,Meena K,Beck A,Meheus L,Lara O,Rooman I,Gravekamp C</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to highlight the potential of NAM+GEM as immunotherapy for advanced pancreatic cancer.</div> <div itemprodp="datePublished">Sun Nov 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33099085"> <div itemprop="name">NDRG2 regulates adherens junction integrity to restrict colitis and tumourigenesis.</div> </a> <div itemprop="about">EBioMedicine</div> <div itemprop="author">Wei M,Ma Y,Shen L,Xu Y,Liu L,Bu X,Guo Z,Qin H,Li Z,Wang Z,Wu K,Yao L,Li J,Zhang J</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to demonstrate that NDRG2 is an essential colonic epithelial barrier regulator and plays an important role in gut homeostasis maintenance and colitis-associated tumour development.</div> <div itemprodp="datePublished">Sun Nov 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33296659"> <div itemprop="name">Regulatory T Cells Support Breast Cancer Progression by Opposing IFN-γ-Dependent Functional Reprogramming of Myeloid Cells.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Clark NM,Martinez LM,Murdock S,deLigio JT,Olex AL,Effi C,Dozmorov MG,Bos PD</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to highlight the strong myeloid dependency of breast cancer and provide the basis for the development of therapeutic strategies based on manipulation of the IFN-γ signaling pathway in monocytes.</div> <div itemprodp="datePublished">Tue Dec 08 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32645949"> <div itemprop="name">Bivalent Inhibitor with Selectivity for Trimeric MMP-9 Amplifies Neutrophil Chemotaxis and Enables Functional Studies on MMP-9 Proteoforms.</div> </a> <div itemprop="about">Cells</div> <div itemprop="author">Nuti E,Rossello A,Cuffaro D,Camodeca C,Van Bael J,van der Maat D,Martens E,Fiten P,Pereira RVS,Ugarte-Berzal E,Gouwy M,Opdenakker G,Vandooren J</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to evaluate the potential of a bivalent carboxylate inhibitor to selectively inhibit the trimeric proteoform of MMP-9 and compare this with a corresponding monovalent inhibitor.</div> <div itemprodp="datePublished">Tue Jul 07 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32385332"> <div itemprop="name">Negative elongation factor complex enables macrophage inflammatory responses by controlling anti-inflammatory gene expression.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Yu L,Zhang B,Deochand D,Sacta MA,Coppo M,Shang Y,Guo Z,Zeng X,Rollins DA,Tharmalingam B,Li R,Chinenov Y,Rogatsky I,Hu X</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to study the contribution of post-initiation steps to macrophage activation.</div> <div itemprodp="datePublished">Fri May 08 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33344115"> <div itemprop="name">Prodrug-Loaded Zirconium Carbide Nanosheets as a Novel Biophotonic Nanoplatform for Effective Treatment of Cancer.</div> </a> <div itemprop="about">Advanced science (Weinheim, Baden-Wurttemberg, Germany)</div> <div itemprop="author">Liu Q,Xie Z,Qiu M,Shim I,Yang Y,Xie S,Yang Q,Wang D,Chen S,Fan T,Ding B,Guo Z,Adah D,Yao X,Zhang Y,Wu H,Wu Z,Wei C,Wang H,Kim HS,Zou Q,Yan Q,Cai Z,Kim JS,Liu LP,Zhang H,Cao Y</div> <div itemprop="description">17-4801-82 was used in Flow Cytometry to unravel a promising biphotonic strategy for precision treatment of cancer.</div> <div itemprodp="datePublished">Tue Dec 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31645721"> <div itemprop="name">Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing.</div> </a> <div itemprop="about">Nature</div> <div itemprop="author">Mahmoudi S,Mancini E,Xu L,Moore A,Jahanbani F,Hebestreit K,Srinivasan R,Li X,Devarajan K,Prélot L,Ang CE,Shibuya Y,Benayoun BA,Chang ALS,Wernig M,Wysocka J,Longaker MT,Snyder MP,Brunet A</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to show that this variability may reflect distinct stochastic ageing trajectories between individuals, and could help in developing personalized strategies to improve iPS cell generation and wound healing in elderly individuals.</div> <div itemprodp="datePublished">Tue Oct 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31645732"> <div itemprop="name">Metabolic regulation of gene expression by histone lactylation.</div> </a> <div itemprop="about">Nature</div> <div itemprop="author">Zhang D,Tang Z,Huang H,Zhou G,Cui C,Weng Y,Liu W,Kim S,Lee S,Perez-Neut M,Ding J,Czyz D,Hu R,Ye Z,He M,Zheng YG,Shuman HA,Dai L,Ren B,Roeder RG,Becker L,Zhao Y</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to show that lactate-derived lactylation of histone lysine residues serves as an epigenetic modification that directly stimulates gene transcription from chromatin.</div> <div itemprodp="datePublished">Tue Oct 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31231034"> <div itemprop="name">A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages.</div> </a> <div itemprop="about">Immunity</div> <div itemprop="author">Buechler MB,Kim KW,Onufer EJ,Williams JW,Little CC,Dominguez CX,Li Q,Sandoval W,Cooper JE,Harris CA,Junttila MR,Randolph GJ,Turley SJ</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to demonstrate that the GATA6 transcriptional program is a common feature of macrophages residing in all visceral body cavities.</div> <div itemprodp="datePublished">Tue Jul 16 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30650375"> <div itemprop="name">Cell-Type-Specific Responses to Interleukin-1 Control Microbial Invasion and Tumor-Elicited Inflammation in Colorectal Cancer.</div> </a> <div itemprop="about">Immunity</div> <div itemprop="author">Dmitrieva-Posocco O,Dzutsev A,Posocco DF,Hou V,Yuan W,Thovarai V,Mufazalov IA,Gunzer M,Shilovskiy IP,Khaitov MR,Trinchieri G,Waisman A,Grivennikov SI</div> <div itemprop="description">17-4801-82 was used in Flow Cytometry to examine the impact of IL-1 signaling, a key regulator of the IL-17 pathway, in different cell types within the CRC microenvironment.</div> <div itemprodp="datePublished">Tue Jan 15 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31467036"> <div itemprop="name">Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Li S,Wu Y,Yang D,Wu C,Ma C,Liu X,Moynagh PN,Wang B,Hu G,Yang S</div> <div itemprop="description">17-4801-82 was used in Flow Cytometry to study how GSDMD deficiency in peripheral myeloid cells impaired the infiltration of immune cells into the CNS, leading to the suppression of neuroinflammation and demyelination.</div> <div itemprodp="datePublished">Mon Nov 04 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30339853"> <div itemprop="name">Engulfment of mast cell secretory granules on skin inflammation boosts dendritic cell migration and priming efficiency.</div> </a> <div itemprop="about">The Journal of allergy and clinical immunology</div> <div itemprop="author">Dudeck J,Froebel J,Kotrba J,Lehmann CHK,Dudziak D,Speier S,Nedospasov SA,Schraven B,Dudeck A</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to show peripheral mast cells can modify dendritic cell functionality to influence lymphoid tissue-borne adaptive immunity.</div> <div itemprodp="datePublished">Wed May 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30528085"> <div itemprop="name">IGF1 Treatment Improves Cardiac Remodeling after Infarction by Targeting Myeloid Cells.</div> </a> <div itemprop="about">Molecular therapy : the journal of the American Society of Gene Therapy</div> <div itemprop="author">Heinen A,Nederlof R,Panjwani P,Spychala A,Tschaidse T,Reffelt H,Boy J,Raupach A,Gödecke S,Petzsch P,Köhrer K,Grandoch M,Petz A,Fischer JW,Alter C,Vasilevska J,Lang P,Gödecke A</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to demonstrate that short-term insulin-like growth factor 1 treatment for 3 days after acute myocardial infarction improved cardiac function after 1 and 4 weeks.</div> <div itemprodp="datePublished">Wed Jan 02 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30755403"> <div itemprop="name">Low-Dose Apatinib Optimizes Tumor Microenvironment and Potentiates Antitumor Effect of PD-1/PD-L1 Blockade in Lung Cancer.</div> </a> <div itemprop="about">Cancer immunology research</div> <div itemprop="author">Zhao S,Ren S,Jiang T,Zhu B,Li X,Zhao C,Jia Y,Shi J,Zhang L,Liu X,Qiao M,Chen X,Su C,Yu H,Zhou C,Zhang J,Camidge DR,Hirsch FR</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to analyze the impact of apatinib, a smallmolecule VEGFR2-TKI, on the TME in murine Lewis lung carcinoma (LLC) models at different doses alone and in combination with an anti–PD-L1.</div> <div itemprodp="datePublished">Mon Apr 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31148354"> <div itemprop="name">Cytochrome P450 26A1 modulates uterine dendritic cells in mice early pregnancy.</div> </a> <div itemprop="about">Journal of cellular and molecular medicine</div> <div itemprop="author">Gu AQ,Li DD,Wei DP,Liu YQ,Ji WH,Yang Y,Lin HY,Peng JP</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to study the relationship between cytochrome P450 26A1 and immune cells during the peri-implantation period in mice.</div> <div itemprodp="datePublished">Thu Aug 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30601409"> <div itemprop="name">The Contribution of the Omentum to the Outcome From Sepsis: An Experimental Animal Study.</div> </a> <div itemprop="about">Shock (Augusta, Ga.)</div> <div itemprop="author">Wang AW,Cauvi DM,Hawisher D,Reyes T,Coimbra R,Bickler S,De Maio A</div> <div itemprop="description">17-4801-82 was used in Flow Cytometry to understand the link between the omentum and possible sepsis.</div> <div itemprodp="datePublished">Sun Dec 01 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31571584"> <div itemprop="name">Hemozoin produced by mammals confers heme tolerance.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Pek RH,Yuan X,Rietzschel N,Zhang J,Jackson L,Nishibori E,Ribeiro A,Simmons W,Jagadeesh J,Sugimoto H,Alam MZ,Garrett L,Haldar M,Ralle M,Phillips JD,Bodine DM,Hamza I</div> <div itemprop="description">17-4801-82 was used in Flow Cytometry to show that mice deficient for the heme transporter SLC48A1 (also known as HRG1) accumulate over ten-fold excess heme in reticuloendothelial macrophage lysosomes that are 10 to 100 times larger than normal.</div> <div itemprodp="datePublished">Tue Oct 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31779710"> <div itemprop="name">MDM2 inhibitor APG-115 synergizes with PD-1 blockade through enhancing antitumor immunity in the tumor microenvironment.</div> </a> <div itemprop="about">Journal for immunotherapy of cancer</div> <div itemprop="author">Fang DD,Tang Q,Kong Y,Wang Q,Gu J,Fang X,Zou P,Rong T,Wang J,Yang D,Zhai Y</div> <div itemprop="description">17-4801-82 was used in Flow cytometry/Cell sorting to demonstrate that p53 activation mediated by APG-115 promotes antitumor immunity in the tumor microenvironment (TME) regardless of the Trp53 status of tumors per se.</div> <div itemprodp="datePublished">Thu Nov 28 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31118934"> <div itemprop="name">Neutrophil Cytosolic Factor 1 in Dendritic Cells Promotes Autoreactive CD8<sup>+</sup> T Cell Activation via Cross-Presentation in Type 1 Diabetes.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Liu C,Whitener RL,Lin A,Xu Y,Chen J,Savinov A,Leiding JW,Wallet MA,Mathews CE</div> <div itemprop="description">17-4801-82 was used in Flow Cytometry to demonstrate that Ncf1 (p47phox) is required for activation and effector function of CD8+ T cells by acting both intrinsically within the T cell as well as within professional antigen presenting cells.</div> <div itemprodp="datePublished">Wed Sep 09 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31089128"> <div itemprop="name">Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Ramakrishna C,Kujawski M,Chu H,Li L,Mazmanian SK,Cantin EM</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to study polysaccharide A as an immunomodulatory symbiosis factor whcih coordinates anti-inflammatory responses during viral infections.</div> <div itemprodp="datePublished">Tue May 14 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31558756"> <div itemprop="name">NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Ershaid N,Sharon Y,Doron H,Raz Y,Shani O,Cohen N,Monteran L,Leider-Trejo L,Ben-Shmuel A,Yassin M,Gerlic M,Ben-Baruch A,Pasmanik-Chor M,Apte R,Erez N</div> <div itemprop="description">17-4801-82 was used in Flow Cytometry to find that fibroblasts sense damage-associated molecular patterns (DAMPs), and in response activate the NLRP3 inflammasome pathway, resulting in instigation of pro-inflammatory signalling and secretion of IL-1β.</div> <div itemprodp="datePublished">Thu Sep 26 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30944305"> <div itemprop="name">Mechanical stretch induces hair regeneration through the alternative activation of macrophages.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Chu SY,Chou CH,Huang HD,Yen MH,Hong HC,Chao PH,Wang YH,Chen PY,Nian SX,Chen YR,Liou LY,Liu YC,Chen HM,Lin FM,Chang YT,Chen CC,Lee OK</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to study the mechanism by which mechanical stretch induces hair regeneration.</div> <div itemprodp="datePublished">Wed Apr 03 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30949049"> <div itemprop="name">The Inhibitory T Cell Receptors PD1 and 2B4 Are Differentially Regulated on CD4 and CD8 T Cells in a Mouse Model of Non-alcoholic Steatohepatitis.</div> </a> <div itemprop="about">Frontiers in pharmacology</div> <div itemprop="author">Hansel C,Erschfeld S,Baues M,Lammers T,Weiskirchen R,Trautwein C,Kroy DC,Drescher HK</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate the expression profile of inhibitory T cell receptors on CD4 and CD8 T cells in a mouse model of non-alcoholic steatohepatitis.</div> <div itemprodp="datePublished">Wed Sep 30 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31285854"> <div itemprop="name">Neutrophil extracellular traps induced by VP1 contribute to pulmonary edema during EV71 infection.</div> </a> <div itemprop="about">Cell death discovery</div> <div itemprop="author">Wang N,Yang X,Sun J,Sun Z,Ma Q,Wang Z,Chen Z,Wang Z,Hu F,Wang H,Zhou L,Zhang M,Xu J</div> <div itemprop="description">17-4801-82 was used in Flow Cytometry to identify a direct role of VP1 in EV71-induced pulmonary edema and demonstrate that NETs may be both harmful and beneficial in EV71 infection.</div> <div itemprodp="datePublished">Wed Sep 30 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29909986"> <div itemprop="name">Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.</div> </a> <div itemprop="about">Cell</div> <div itemprop="author">Ziegler PK,Bollrath J,Pallangyo CK,Matsutani T,Canli Ö,De Oliveira T,Diamanti MA,Müller N,Gamrekelashvili J,Putoczki T,Horst D,Mankan AK,Öner MG,Müller S,Müller-Höcker J,Kirchner T,Slotta-Huspenina J,Taketo MM,Reinheckel T,Dröse S,Larner AC,Wels WS,Ernst M,Greten TF,Arkan MC,Korn T,Wirth D,Greten FR</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to reveal a link between mitochondrial function, lysosomal integrity and MHC class I presentation in intestinal epithelial cells.</div> <div itemprodp="datePublished">Thu Jun 28 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29921315"> <div itemprop="name">Expression of ID4 protein in breast cancer cells induces reprogramming of tumour-associated macrophages.</div> </a> <div itemprop="about">Breast cancer research : BCR</div> <div itemprop="author">Donzelli S,Milano E,Pruszko M,Sacconi A,Masciarelli S,Iosue I,Melucci E,Gallo E,Terrenato I,Mottolese M,Zylicz M,Zylicz A,Fazi F,Blandino G,Fontemaggi G</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate whether ID4 exerts its pro-angiogenic function while also modulating the activity of tumour-associated macrophages in breast cancer.</div> <div itemprodp="datePublished">Tue Jun 19 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30064125"> <div itemprop="name">Adipocyte-Derived Exosomes Carrying Sonic Hedgehog Mediate M1 Macrophage Polarization-Induced Insulin Resistance via Ptch and PI3K Pathways.</div> </a> <div itemprop="about">Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology</div> <div itemprop="author">Song M,Han L,Chen FF,Wang D,Wang F,Zhang L,Wang ZH,Zhong M,Tang MX,Zhang W</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to study the impact of adipocyte-derived exosomes carrying Sonic hedgehog on the pro-inflammatory activation of macrophages and consequently, adipocyte insulin resistance.</div> <div itemprodp="datePublished">Fri Sep 14 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30210491"> <div itemprop="name">GM-CSF Quantity Has a Selective Effect on Granulocytic vs. Monocytic Myeloid Development and Function.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Sun L,Rautela J,Delconte RB,Souza-Fonseca-Guimaraes F,Carrington EM,Schenk RL,Herold MJ,Huntington ND,Lew AM,Xu Y,Zhan Y</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to study whether the dosage of GM-CSF regulates the development of three types of myeloid cells from cultured bone marrow cells.</div> <div itemprodp="datePublished">Fri Sep 20 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29593222"> <div itemprop="name">CD4<sup>+</sup> and CD8<sup>+</sup> T Cells Exert Regulatory Properties During Experimental Acute Aristolochic Acid Nephropathy.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Baudoux T,Husson C,De Prez E,Jadot I,Antoine MH,Nortier JL,Hougardy JM</div> <div itemprop="description">17-4801-82 was used in Flow Cytometry to investigate the role of T-cell subpopulations in the acute phase of the mouse mode for transient acute proximal tubule necrosis.</div> <div itemprodp="datePublished">Wed Mar 28 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30096846"> <div itemprop="name">Removal of the C6 Vaccinia Virus Interferon-β Inhibitor in the Hepatitis C Vaccine Candidate MVA-HCV Elicited in Mice High Immunogenicity in Spite of Reduced Host Gene Expression.</div> </a> <div itemprop="about">Viruses</div> <div itemprop="author">Marín MQ,Pérez P,Gómez CE,Sorzano CÓS,Esteban M,García-Arriaza J</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to support the consideration of these vectors as potential vaccine candidates against HCV.</div> <div itemprodp="datePublished">Wed Aug 08 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29563328"> <div itemprop="name">Peroxisomal β-oxidation regulates whole body metabolism, inflammatory vigor, and pathogenesis of nonalcoholic fatty liver disease.</div> </a> <div itemprop="about">JCI insight</div> <div itemprop="author">Moreno-Fernandez ME,Giles DA,Stankiewicz TE,Sheridan R,Karns R,Cappelletti M,Lampe K,Mukherjee R,Sina C,Sallese A,Bridges JP,Hogan SP,Aronow BJ,Hoebe K,Divanovic S</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to demonstrate that β-oxidation links metabolism and immune responsiveness.</div> <div itemprodp="datePublished">Thu Mar 22 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29279328"> <div itemprop="name">Hydrogen sulfide inhibits NLRP3 inflammasome activation and reduces cytokine production both <i>in vitro</i> and in a mouse model of inflammation.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Castelblanco M,Lugrin J,Ehirchiou D,Nasi S,Ishii I,So A,Martinon F,Busso N</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to study the effects of exogenous and endogenous hydorgen sulfide (H2S) on NLRP3 inflammasome activation.</div> <div itemprodp="datePublished">Fri Feb 16 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30333482"> <div itemprop="name">Lin<sup>-</sup>CCR2<sup>+</sup> hematopoietic stem and progenitor cells overcome resistance to PD-1 blockade.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Flores CT,Wildes TJ,Drake JA,Moore GL,Dean BD,Abraham RS,Mitchell DA</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to elucidate a novel role for CCR2+ haematopoietic stem cells in overcoming brain tumour resistance to PD-1 checkpoint blockade and adoptive cellular therapy in multiple invasive brain tumour models.</div> <div itemprodp="datePublished">Wed Oct 17 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30250029"> <div itemprop="name">Eosinophil recruitment is dynamically regulated by interplay among lung dendritic cell subsets after allergen challenge.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Yi S,Zhai J,Niu R,Zhu G,Wang M,Liu J,Huang H,Wang Y,Jing X,Kang L,Song W,Shi Y,Tang H</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to suggest that different lung antigen-presenting cells modulate lung cDC1-mediated eosinophil recruitment dynamically.</div> <div itemprodp="datePublished">Mon Sep 24 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29892213"> <div itemprop="name">Neuronal Dysfunction and Behavioral Abnormalities Are Evoked by Neural Cells and Aggravated by Inflammatory Microglia in Peroxisomal β-Oxidation Deficiency.</div> </a> <div itemprop="about">Frontiers in cellular neuroscience</div> <div itemprop="author">Beckers L,Stroobants S,D'Hooge R,Baes M</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to study the impact of microgliosis on neuropathology, behaviour and clinical decline in neuropathological conditions.</div> <div itemprodp="datePublished">Wed Sep 30 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30333823"> <div itemprop="name">Growth Hormone (GH) Deficient Mice With GHRH Gene Ablation Are Severely Deficient in Vaccine and Immune Responses Against <i>Streptococcus pneumoniae</i>.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Farhat K,Bodart G,Charlet-Renard C,Desmet CJ,Moutschen M,Beguin Y,Baron F,Melin P,Quatresooz P,Parent AS,Desmecht D,Sirard JC,Salvatori R,Martens H,Geenen VG</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate vaccinal and anti-infectious responses of Ghrh-/- mice against S. pneumoniae, a pathogen carrying T-independent antigens.</div> <div itemprodp="datePublished">Wed Sep 25 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30538250"> <div itemprop="name">Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Chaudhury S,O'Connor C,Cañete A,Bittencourt-Silvestre J,Sarrou E,Prendergast Á,Choi J,Johnston P,Wells CA,Gibson B,Keeshan K</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to study paediatric acute myeloid leukaemia biology, and provide murine models that offer the potential for developing paediatric specific therapeutic strategies.</div> <div itemprodp="datePublished">Tue Dec 11 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28803730"> <div itemprop="name">Renal Sodium Gradient Orchestrates a Dynamic Antibacterial Defense Zone.</div> </a> <div itemprop="about">Cell</div> <div itemprop="author">Berry MR,Mathews RJ,Ferdinand JR,Jing C,Loudon KW,Wlodek E,Dennison TW,Kuper C,Neuhofer W,Clatworthy MR</div> <div itemprop="description">17-4801-82 was used in Flow Cytometry to reveal a critical accessory role for the homeostatic function of a vital organ in optimizing tissue defense.</div> <div itemprodp="datePublished">Thu Aug 24 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28844693"> <div itemprop="name">Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation.</div> </a> <div itemprop="about">Cell</div> <div itemprop="author">Wang S,Xia P,Chen Y,Qu Y,Xiong Z,Ye B,Du Y,Tian Y,Yin Z,Xu Z,Fan Z</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to identify a regulatory subpopulation of innate lymphoid cells that exists in the gut, and harbour a unique gene identity.</div> <div itemprodp="datePublished">Thu Sep 21 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28802038"> <div itemprop="name">TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease.</div> </a> <div itemprop="about">Cell</div> <div itemprop="author">Ulland TK,Song WM,Huang SC,Ulrich JD,Sergushichev A,Beatty WL,Loboda AA,Zhou Y,Cairns NJ,Kambal A,Loginicheva E,Gilfillan S,Cella M,Virgin HW,Unanue ER,Wang Y,Artyomov MN,Holtzman DM,Colonna M</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to demonstrate that TREM2 enables microglial responses during Alzheimer's disease by sustaining cellular energetic and biosynthetic metabolism.</div> <div itemprodp="datePublished">Thu Aug 10 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29232557"> <div itemprop="name">Myeloid Cell-Derived Reactive Oxygen Species Induce Epithelial Mutagenesis.</div> </a> <div itemprop="about">Cancer cell</div> <div itemprop="author">Canli Ö,Nicolas AM,Gupta J,Finkelmeier F,Goncharova O,Pesic M,Neumann T,Horst D,Löwer M,Sahin U,Greten FR</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to identify a crosstalk between myeloid cell-derived reactive oxygen species molecules, oxidative DNA damage and tumour necrosis factor α-mediated signalling to orchestrate a tumour-promoting microenvironment causing invasive cancer.</div> <div itemprodp="datePublished">Mon Dec 11 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28407483"> <div itemprop="name">Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction.</div> </a> <div itemprop="about">Cell host & microbe</div> <div itemprop="author">Thevaranjan N,Puchta A,Schulz C,Naidoo A,Szamosi JC,Verschoor CP,Loukov D,Schenck LP,Jury J,Foley KP,Schertzer JD,Larché MJ,Davidson DJ,Verdú EF,Surette MG,Bowdish DME</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to study the potential of changes to the microbiota as a strategy for reducing age-associated inflammation and the accompanying morbidity.</div> <div itemprodp="datePublished">Wed Apr 12 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27869648"> <div itemprop="name">Hippo signaling interactions with Wnt/β-catenin and Notch signaling repress liver tumorigenesis.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Kim W,Khan SK,Gvozdenovic-Jeremic J,Kim Y,Dahlman J,Kim H,Park O,Ishitani T,Jho EH,Gao B,Yang Y</div> <div itemprop="description">17480182 was used in flow cytometry to demonstrate that the Hippo, Wnt/beta-catenin, and Notch pathways interact to regulate liver size and inhibit hepatocellular carcinoma</div> <div itemprodp="datePublished">Tue Jan 03 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28356391"> <div itemprop="name">TLR4 signals in B lymphocytes are transduced via the B cell antigen receptor and SYK.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Schweighoffer E,Nys J,Vanes L,Smithers N,Tybulewicz VLJ</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to demonstrate two distinct signalling pathways for TLR4, one via the BCR and the other through MYD88.</div> <div itemprodp="datePublished">Mon May 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28747424"> <div itemprop="name">ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Schwartz C,Khan AR,Floudas A,Saunders SP,Hams E,Rodewald HR,McKenzie ANJ,Fallon PG</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to study how group 2 innate lymphoid cells regulate adaptive Th2 cell functions.</div> <div itemprodp="datePublished">Mon Sep 04 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28923858"> <div itemprop="name">Anti-CD137 Suppresses Tumor Growth by Blocking Reverse Signaling by CD137 Ligand.</div> </a> <div itemprop="about">Cancer research</div> <div itemprop="author">Kang SW,Lee SC,Park SH,Kim J,Kim HH,Lee HW,Seo SK,Kwon BS,Cho HR,Kwon B</div> <div itemprop="description">17-4801-82 was used in Flow Cytometry to report findings related to reverse signaling by CD137 ligand (CD137L) in antigen-presenting dendritic cells (DC) in tumors that address these paradoxical results.</div> <div itemprodp="datePublished">Wed Nov 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27834952"> <div itemprop="name">Double-stranded RNA promotes CTL-independent tumor cytolysis mediated by CD11b<sup>+</sup>Ly6G<sup>+</sup> intratumor myeloid cells through the TICAM-1 signaling pathway.</div> </a> <div itemprop="about">Cell death and differentiation</div> <div itemprop="author">Shime H,Matsumoto M,Seya T</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to study the response of CD11b+Ly6G+ granulocytic myeloid-derived suppressor cells to polyI:C in an EL4 tumour implant model.</div> <div itemprodp="datePublished">Wed Mar 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28614908"> <div itemprop="name">Adenoviral production of interleukin-2 at the tumor site removes the need for systemic postconditioning in adoptive cell therapy.</div> </a> <div itemprop="about">International journal of cancer</div> <div itemprop="author">Santos JM,Havunen R,Siurala M,Cervera-Carrascon V,Tähtinen S,Sorsa S,Anttila M,Karell P,Kanerva A,Hemminki A</div> <div itemprop="description">17-4801-82 was used in Flow Cytometry to study the efficacy and safety of intratumorally administered IL-2 coding adenoviruses in combination with lymphocyte therapy in Syrian hamsters bearing pancreatic tumours.</div> <div itemprodp="datePublished">Sun Oct 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28676836"> <div itemprop="name">Genetic Nrf2 Overactivation Inhibits the Deleterious Effects Induced by Hepatocyte-Specific c-met Deletion during the Progression of NASH.</div> </a> <div itemprop="about">Oxidative medicine and cellular longevity</div> <div itemprop="author">Ramadori P,Drescher H,Erschfeld S,Fragoulis A,Kensler TW,Wruck CJ,Cubero FJ,Trautwein C,Streetz KL,Kroy DC</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to elucidate the effect of Nrf2 overactivation on cellular events in c-met deficient hepatocytes.</div> <div itemprodp="datePublished">Wed Jan 31 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29019857"> <div itemprop="name">Interleukin-27 Is a Potential Rescue Therapy for Acute Severe Colitis Through Interleukin-10-Dependent, T-Cell-Independent Attenuation of Colonic Mucosal Innate Immune Responses.</div> </a> <div itemprop="about">Inflammatory bowel diseases</div> <div itemprop="author">McLean MH,Andrews C,Hanson ML,Baseler WA,Anver MR,Senkevitch E,Staniszewska AK,Smith C,Davies LC,Hixon J,Li W,Shen W,Steidler L,Durum SK</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to define the efficacy of interleukin (IL)-27 in acute severe colitis and characterise novel IL-27-driven mechanisms of immunosuppression in the colonic mucosa.</div> <div itemprodp="datePublished">Wed Nov 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27816922"> <div itemprop="name">Rediscovering peritoneal macrophages in a murine endometriosis model.</div> </a> <div itemprop="about">Human reproduction (Oxford, England)</div> <div itemprop="author">Yuan M,Li D,An M,Li Q,Zhang L,Wang G</div> <div itemprop="description">17-4801 was used in Flow Cytometry to study the role of large and small peritoneal macrophages in endometriosis.</div> <div itemprodp="datePublished">Sun Jan 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28159899"> <div itemprop="name">Cross-Presentation of Soluble and Cell-Associated Antigen by Murine Hepatocytes Is Enhanced by Collectrin Expression.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Dolina JS,Cechova S,Rudy CK,Sung SJ,Tang WW,Lee J,Hahn YS,Le TH</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to identify the functional role of collectrin in the liver.</div> <div itemprodp="datePublished">Wed Mar 15 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28901417"> <div itemprop="name">Discrimination of the heterogeneity of bone marrow‑derived dendritic cells.</div> </a> <div itemprop="about">Molecular medicine reports</div> <div itemprop="author">Wang J,Dai X,Hsu C,Ming C,He Y,Zhang J,Wei L,Zhou P,Wang CY,Yang J,Gong N</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to demonstrate that BM-derived DC culture systems were heterogeneous, comprising of non-adherent cells, adherent cells, mixed cells and firmly adherent cells.</div> <div itemprodp="datePublished">Wed Nov 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28851689"> <div itemprop="name">The Second-Generation PGI2 Analogue Treprostinil Fails to Chemoprevent Tumors in a Murine Lung Adenocarcinoma Model.</div> </a> <div itemprop="about">Cancer prevention research (Philadelphia, Pa.)</div> <div itemprop="author">Dwyer-Nield L,Hickey GA,Friedman M,Choo K,McArthur DG,Tennis MA,New ML,Geraci M,Keith RL</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to study the ability of treprostinil to chemoprevent urethane-induced murine lung adenocarcinoma.</div> <div itemprodp="datePublished">Wed Nov 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28367448"> <div itemprop="name">Differential S1P Receptor Profiles on M1- and M2-Polarized Macrophages Affect Macrophage Cytokine Production and Migration.</div> </a> <div itemprop="about">BioMed research international</div> <div itemprop="author">Müller J,von Bernstorff W,Heidecke CD,Schulze T</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to show the expression of different specific S1P receptor profiles may provide a possibility to selectively influence M1- or M2-polarized macrophages.</div> <div itemprodp="datePublished">Fri Apr 28 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27993215"> <div itemprop="name">Anti-PD-L1 peptide improves survival in sepsis.</div> </a> <div itemprop="about">The Journal of surgical research</div> <div itemprop="author">Shindo Y,McDonough JS,Chang KC,Ramachandra M,Sasikumar PG,Hotchkiss RS</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to assess the efficacy of a novel short-acting peptide that inhibits programmed cell death 1 and its ligand signalling, in a clinically relevant second-hit fungal sepsis model.</div> <div itemprodp="datePublished">Wed Feb 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28250928"> <div itemprop="name">Location of tumor affects local and distant immune cell type and number.</div> </a> <div itemprop="about">Immunity, inflammation and disease</div> <div itemprop="author">Hensel JA,Khattar V,Ashton R,Lee C,Siegal GP,Ponnazhagan S</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to demonstrate that location of tumour, and not simply the tumour itself, has a definitive role in regulating immune effectors.</div> <div itemprodp="datePublished">Wed Mar 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29170400"> <div itemprop="name">Host STING-dependent MDSC mobilization drives extrinsic radiation resistance.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Liang H,Deng L,Hou Y,Meng X,Huang X,Rao E,Zheng W,Mauceri H,Mack M,Xu M,Fu YX,Weichselbaum RR</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to demonstrate how extrinsic resistance develops after local ablative radiation that relies on the immunosuppressive action of STING.</div> <div itemprodp="datePublished">Thu Nov 23 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29117241"> <div itemprop="name">IFNGR1 signaling is associated with adverse pregnancy outcomes during infection with malaria parasites.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Niikura M,Inoue SI,Mineo S,Asahi H,Kobayashi F</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to explore the role of IFN-γ receptor 1 signalling in placental pathology during severe malaria using luciferase-expressing rodent malaria parasites, P. berghei NK65.</div> <div itemprodp="datePublished">Wed Nov 29 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29203865"> <div itemprop="name">Albumin/vaccine nanocomplexes that assemble in vivo for combination cancer immunotherapy.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Zhu G,Lynn GM,Jacobson O,Chen K,Liu Y,Zhang H,Ma Y,Zhang F,Tian R,Ni Q,Cheng S,Wang Z,Lu N,Yung BC,Wang Z,Lang L,Fu X,Jin A,Weiss ID,Vishwasrao H,Niu G,Shroff H,Klinman DM,Seder RA,Chen X</div> <div itemprop="description">17-4801-82 was used in Flow cytometry/Cell sorting to develop albumin/AlbiVax nanocomplexes that self-assemble in vivo from AlbiVax and endogenous albumin for efficient vaccine delivery and potent cancer immunotherapy.</div> <div itemprodp="datePublished">Tue Dec 05 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28710351"> <div itemprop="name">Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Costa-Gouveia J,Pancani E,Jouny S,Machelart A,Delorme V,Salzano G,Iantomasi R,Piveteau C,Queval CJ,Song OR,Flipo M,Deprez B,Saint-André JP,Hureaux J,Majlessi L,Willand N,Baulard A,Brodin P,Gref R</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to pave the way for a future use of pCD NPs for the pulmonary delivery of the [ETH:Booster] pair in TB chemotherapy.</div> <div itemprodp="datePublished">Fri Jul 14 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28839138"> <div itemprop="name">Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Kim DS,Dastidar H,Zhang C,Zemp FJ,Lau K,Ernst M,Rakic A,Sikdar S,Rajwani J,Naumenko V,Balce DR,Ewanchuk BW,Tailor P,Yates RM,Jenne C,Gafuik C,Mahoney DJ</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to show that SMC and OV therapies combination also synergize in vivo by promoting anticancer immunity through an increase in CD8(+) T-cell response.</div> <div itemprodp="datePublished">Thu Aug 24 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28439546"> <div itemprop="name">Inositol polyphosphate multikinase promotes Toll-like receptor-induced inflammation by stabilizing TRAF6.</div> </a> <div itemprop="about">Science advances</div> <div itemprop="author">Kim E,Beon J,Lee S,Park SJ,Ahn H,Kim MG,Park JE,Kim W,Yuk JM,Kang SJ,Lee SH,Jo EK,Seong RH,Kim S</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate how TRAF6 protein stability is controlled in TLR signalling, showing that Inositol polyphosphate multikinase stabilises TRAF6 and promotes TLR-induced inflammation.</div> <div itemprodp="datePublished">Sat Apr 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29207662"> <div itemprop="name">Tumor-associated macrophages promote neuroblastoma via STAT3 phosphorylation and up-regulation of c-MYC.</div> </a> <div itemprop="about">Oncotarget</div> <div itemprop="author">Hadjidaniel MD,Muthugounder S,Hung LT,Sheard MA,Shirinbak S,Chan RY,Nakata R,Borriello L,Malvar J,Kennedy RJ,Iwakura H,Akamizu T,Sposto R,Shimada H,DeClerck YA,Asgharzadeh S</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to indicate a novel role of tumour-associated macrophages as inducers of MYC expression in neuroblastomas lacking independent oncogene activation.</div> <div itemprodp="datePublished">Tue Oct 31 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28664154"> <div itemprop="name">Geldanamycin Reduces Acute Respiratory Distress Syndrome and Promotes the Survival of Mice Infected with the Highly Virulent H5N1 Influenza Virus.</div> </a> <div itemprop="about">Frontiers in cellular and infection microbiology</div> <div itemprop="author">Wang C,Liu P,Luo J,Ding H,Gao Y,Sun L,Luo F,Liu X,He H</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to show geldanamycin plays an important role in attenuating virus infection-induced acute lung injury/acute respiratory distress syndrome by reducing the host's inflammatory responses.</div> <div itemprodp="datePublished">Mon Feb 26 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26325539"> <div itemprop="name">Macrophage autophagy limits acute toxic liver injury in mice through down regulation of interleukin-1β.</div> </a> <div itemprop="about">Journal of hepatology</div> <div itemprop="author">Ilyas G,Zhao E,Liu K,Lin Y,Tesfa L,Tanaka KE,Czaja MJ</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to show that macrophage autophagy functions to limit acute toxin-induced liver injury and death by inhibiting the generation of inflammasome-dependent IL-1β.</div> <div itemprodp="datePublished">Fri Jan 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27111842"> <div itemprop="name">Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal.</div> </a> <div itemprop="about">Nature cell biology</div> <div itemprop="author">Pietras EM,Mirantes-Barbeito C,Fong S,Loeffler D,Kovtonyuk LV,Zhang S,Lakshminarasimhan R,Chin CP,Techner JM,Will B,Nerlov C,Steidl U,Manz MG,Schroeder T,Passegué E</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to identify a critical regulatory circuit that tailors HSC responses to acute needs, and is likely to underlie deregulated blood homeostasis in chronic inflammation conditions.</div> <div itemprodp="datePublished">Wed Jun 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26830849"> <div itemprop="name">MicroRNA-181b Improves Glucose Homeostasis and Insulin Sensitivity by Regulating Endothelial Function in White Adipose Tissue.</div> </a> <div itemprop="about">Circulation research</div> <div itemprop="author">Sun X,Lin J,Zhang Y,Kang S,Belkin N,Wara AK,Icli B,Hamburg NM,Li D,Feinberg MW</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to assess whether microRNA-181b impacts the pathogenesis of insulin resistance by regulating endothelial cell function in adipose tissue during obesity.</div> <div itemprodp="datePublished">Fri Mar 04 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27427981"> <div itemprop="name">p21 mediates macrophage reprogramming through regulation of p50-p50 NF-κB and IFN-β.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Rackov G,Hernández-Jiménez E,Shokri R,Carmona-Rodríguez L,Mañes S,Álvarez-Mon M,López-Collazo E,Martínez-A C,Balomenos D</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to determine whether p21 regulates macrophage reprogramming by shifting the balance between active p65-p50 and inhibitory p50-p50 NF-κB pathways.</div> <div itemprodp="datePublished">Mon Aug 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27412700"> <div itemprop="name">Transcriptome-based profiling of yolk sac-derived macrophages reveals a role for Irf8 in macrophage maturation.</div> </a> <div itemprop="about">The EMBO journal</div> <div itemprop="author">Hagemeyer N,Kierdorf K,Frenzel K,Xue J,Ringelhan M,Abdullah Z,Godin I,Wieghofer P,Costa Jordão MJ,Ulas T,Yorgancioglu G,Rosenbauer F,Knolle PA,Heikenwalder M,Schultze JL,Prinz M</div> <div itemprop="description">17-4801 was used in Flow Cytometry to study the cellular and molecular mechanisms which govern the origin and developmental pathways of tissue macrophages.</div> <div itemprodp="datePublished">Mon Aug 15 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26129648"> <div itemprop="name">Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis.</div> </a> <div itemprop="about">Mucosal immunology</div> <div itemprop="author">Mohapatra A,Van Dyken SJ,Schneider C,Nussbaum JC,Liang HE,Locksley RM</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to study how ILC2s link alveolar function to regulation of airway flow, revealing a key interaction between resident lymphoid and structural cells that might underlie similar organisational hierarchies in other organs.</div> <div itemprodp="datePublished">Fri Jan 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26349655"> <div itemprop="name">β7-Integrin exacerbates experimental DSS-induced colitis in mice by directing inflammatory monocytes into the colon.</div> </a> <div itemprop="about">Mucosal immunology</div> <div itemprop="author">Schippers A,Muschaweck M,Clahsen T,Tautorat S,Grieb L,Tenbrock K,Gaßler N,Wagner N</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to elucidate the significance of β7-integrin expression on innate immune cells for the pathogenesis of inflammatory bowel disease.</div> <div itemprodp="datePublished">Tue Mar 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27091452"> <div itemprop="name">Osteopontin ablation ameliorates muscular dystrophy by shifting macrophages to a pro-regenerative phenotype.</div> </a> <div itemprop="about">The Journal of cell biology</div> <div itemprop="author">Capote J,Kramerova I,Martinez L,Vetrone S,Barton ER,Sweeney HL,Miceli MC,Spencer MJ</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to demonstrate that OPN ablation promotes muscle repair via macrophage secretion of pro-myogenic growth factors.</div> <div itemprodp="datePublished">Mon Apr 25 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26815999"> <div itemprop="name">A20 Deficiency in Lung Epithelial Cells Protects against Influenza A Virus Infection.</div> </a> <div itemprop="about">PLoS pathogens</div> <div itemprop="author">Maelfait J,Roose K,Vereecke L,Mc Guire C,Sze M,Schuijs MJ,Willart M,Ibañez LI,Hammad H,Lambrecht BN,Beyaert R,Saelens X,van Loo G</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate the function of A20 in club cells in antiviral immunity, showing that deficiency in A20 protects against influenza virus infection.</div> <div itemprodp="datePublished">Fri Jan 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27224507"> <div itemprop="name">CSF-1 receptor signalling is governed by pre-requisite EHD1 mediated receptor display on the macrophage cell surface.</div> </a> <div itemprop="about">Cellular signalling</div> <div itemprop="author">Cypher LR,Bielecki TA,Huang L,An W,Iseka F,Tom E,Storck MD,Hoppe AD,Band V,Band H</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate the mechanism underlying macrophage receptor trafficking.</div> <div itemprodp="datePublished">Thu Sep 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27464342"> <div itemprop="name">Model-Based Characterization of Inflammatory Gene Expression Patterns of Activated Macrophages.</div> </a> <div itemprop="about">PLoS computational biology</div> <div itemprop="author">Rex J,Albrecht U,Ehlting C,Thomas M,Zanger UM,Sawodny O,Häussinger D,Ederer M,Feuer R,Bode JG</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate inflammatory gene expression patterns of activated macrophages via model-based characterization.</div> <div itemprodp="datePublished">Fri Jul 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26644379"> <div itemprop="name">Low-Dose Intestinal Trichuris muris Infection Alters the Lung Immune Microenvironment and Can Suppress Allergic Airway Inflammation.</div> </a> <div itemprop="about">Infection and immunity</div> <div itemprop="author">Chenery AL,Antignano F,Burrows K,Scheer S,Perona-Wright G,Zaph C</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to study crosstalk between the intestine and lung during disease, showing that low-dose intestinal Trichuris muris infection alters the lung immune microenvironment.</div> <div itemprodp="datePublished">Mon Feb 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27053419"> <div itemprop="name">Deficiency of the TLR4 analogue RP105 aggravates vein graft disease by inducing a pro-inflammatory response.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Wezel A,de Vries MR,Maassen JM,Kip P,Peters EA,Karper JC,Kuiper J,Bot I,Quax PHA</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to determine aggravated vein graft disease caused by RP105 deficiency results from an increased local inflammatory response.</div> <div itemprodp="datePublished">Thu Apr 07 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27716790"> <div itemprop="name">Cathepsin L Helps to Defend Mice from Infection with Influenza A.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Xu X,Greenland JR,Gotts JE,Matthay MA,Caughey GH</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to show that cathepsin L supports innate and adaptive responses, confering a survival advantage on mice infected with the orthomyxovirus influenza A.</div> <div itemprodp="datePublished">Tue Jun 20 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27382057"> <div itemprop="name">Chromatin Remodeler Recruitment during Macrophage Differentiation Facilitates Transcription Factor Binding to Enhancers in Mature Cells.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">McAndrew MJ,Gjidoda A,Tagore M,Miksanek T,Floer M</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to demonstrate how macrophage-specific gene enhancers are accessible in differentiating macrophages to facilitate induction into mature cells.</div> <div itemprodp="datePublished">Fri Aug 26 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27471636"> <div itemprop="name">CXCL16-positive dendritic cells enhance invariant natural killer T cell-dependent IFNγ production and tumor control.</div> </a> <div itemprop="about">Oncoimmunology</div> <div itemprop="author">Veinotte L,Gebremeskel S,Johnston B</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to study the co-stimulatory role of CXCR6/CXCL16 interactions in glycolipid-dependent invariant natural killer T (iNKT) cell activation and tumour control, showing that CXCL16-positive dendritic cells enhance iNKT cell-dependent IFNγ production and tumor control.</div> <div itemprodp="datePublished">Wed Jun 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27489105"> <div itemprop="name">NADPH Oxidases Are Essential for Macrophage Differentiation.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Xu Q,Choksi S,Qu J,Jang J,Choe M,Banfi B,Engelhardt JF,Liu ZG</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate the role of NOX1 and NOX2 in macrophage differentiation and tumor progression.</div> <div itemprodp="datePublished">Fri Sep 16 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27143385"> <div itemprop="name">Suppression of Antitumor Immune Responses by Human Papillomavirus through Epigenetic Downregulation of CXCL14.</div> </a> <div itemprop="about">mBio</div> <div itemprop="author">Cicchini L,Westrich JA,Xu T,Vermeer DW,Berger JN,Clambey ET,Lee D,Song JI,Lambert PF,Greer RO,Lee JH,Pyeon D</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate the underlying mechanism of immune suppression induced by HPV oncoprotein E7, showing that there is epigenetic downregulation of CXCL14.</div> <div itemprodp="datePublished">Tue May 03 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27541266"> <div itemprop="name">Reprogramming of Normal Fibroblasts into Cancer-Associated Fibroblasts by miRNAs-Mediated CCL2/VEGFA Signaling.</div> </a> <div itemprop="about">PLoS genetics</div> <div itemprop="author">Shen H,Yu X,Yang F,Zhang Z,Shen J,Sun J,Choksi S,Jitkaew S,Shu Y</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate the mechanism of how cancer cells transform normal fibroblasts into cancer-associated fibroblasts.</div> <div itemprodp="datePublished">Mon Aug 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26670608"> <div itemprop="name">Involvement of Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-induced Incomplete Cytokinesis in the Polyploidization of Osteoclasts.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Takegahara N,Kim H,Mizuno H,Sakaue-Sawano A,Miyawaki A,Tomura M,Kanagawa O,Ishii M,Choi Y</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to determine the mechanisms by which polyploidization of osteoclasts are controlled- an essential process for bone-resorbing activity.</div> <div itemprodp="datePublished">Fri Feb 12 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27111140"> <div itemprop="name">Neutropenic Mice Provide Insight into the Role of Skin-Infiltrating Neutrophils in the Host Protective Immunity against Filarial Infective Larvae.</div> </a> <div itemprop="about">PLoS neglected tropical diseases</div> <div itemprop="author">Pionnier N,Brotin E,Karadjian G,Hemon P,Gaudin-Nomé F,Vallarino-Lhermitte N,Nieguitsila A,Fercoq F,Aknin ML,Marin-Esteban V,Chollet-Martin S,Schlecht-Louf G,Bachelerie F,Martin C</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to demonstrate that neutrophils contribute to early anti-filarial host responses via oxidative burst, degranulation and NETosis.</div> <div itemprodp="datePublished">Fri Apr 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27886180"> <div itemprop="name">MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Wilson R,Espinosa-Diez C,Kanner N,Chatterjee N,Ruhl R,Hipfinger C,Advani SJ,Li J,Khan OF,Franovic A,Weis SM,Kumar S,Coussens LM,Anderson DG,Chen CC,Cheresh DA,Anand S</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to demonstrate a unique mechanism by which ectopic microRNA-103 can manipulate tumour-associated endothelial cells to enhance tumour cell death.</div> <div itemprodp="datePublished">Fri Nov 25 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27869129"> <div itemprop="name">Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Cheng H,Ang HY,A El Farran C,Li P,Fang HT,Liu TM,Kong SL,Chin ML,Ling WY,Lim EK,Li H,Huber T,Loh KM,Loh YH,Lim B</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to demonstrate how it is possible to reprogram mouse embryonic fibroblasts into engraftable blood progenitors.</div> <div itemprodp="datePublished">Mon Nov 21 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27224286"> <div itemprop="name">Involvement of TGF-β1/Smad3 Signaling in Carbon Tetrachloride-Induced Acute Liver Injury in Mice.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Niu L,Cui X,Qi Y,Xie D,Wu Q,Chen X,Ge J,Liu Z</div> <div itemprop="description">17-4801 was used in Immunofluorescence to study how the activation of TGF-β signaling contributes to the CCl4-induced acute liver injury.</div> <div itemprodp="datePublished">Mon Jul 10 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26239911"> <div itemprop="name">Adipose tissue macrophages in non-rodent mammals: a comparative study.</div> </a> <div itemprop="about">Cell and tissue research</div> <div itemprop="author">Ampem G,Azegrouz H,Bacsadi Á,Balogh L,Schmidt S,Thuróczy J,Röszer T</div> <div itemprop="description">17-4801-82 was used in Flow cytometry/Cell sorting to show that the presence of ATMs is a general trait of mammals, and that the interaction between the adipose cells and SVF immune cells might be evolutionarily conserved among mammals.</div> <div itemprodp="datePublished">Mon Feb 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27622016"> <div itemprop="name">Timing of CSF-1/CSF-1R signaling blockade is critical to improving responses to CTLA-4 based immunotherapy.</div> </a> <div itemprop="about">Oncoimmunology</div> <div itemprop="author">Holmgaard RB,Brachfeld A,Gasmi B,Jones DR,Mattar M,Doman T,Murphy M,Schaer D,Wolchok JD,Merghoub T</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to show that both CSF-1 and its receptor (CSF-1R) are frequently expressed in tumors from cancer patients, and that this expression correlates with tumor-infiltration of MDSCs.</div> <div itemprodp="datePublished">Fri Jul 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26228159"> <div itemprop="name">Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53.</div> </a> <div itemprop="about">Science (New York, N.Y.)</div> <div itemprop="author">Yoon KW,Byun S,Kwon E,Hwang SY,Chu K,Hiraki M,Jo SH,Weins A,Hakroush S,Cebulla A,Sykes DB,Greka A,Mundel P,Fisher DE,Mandinova A,Lee SW</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to reveal that p53-induced expression of death domain 1α regulates the efficient clearance of dead cells and proper immune tolerance.</div> <div itemprodp="datePublished">Fri Jul 31 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26206316"> <div itemprop="name">High salt primes a specific activation state of macrophages, M(Na).</div> </a> <div itemprop="about">Cell research</div> <div itemprop="author">Zhang WC,Zheng XJ,Du LJ,Sun JY,Shen ZX,Shi C,Sun S,Zhang Z,Chen XQ,Qin M,Liu X,Tao J,Jia L,Fan HY,Zhou B,Yu Y,Ying H,Hui L,Liu X,Yi X,Liu X,Zhang L,Duan SZ</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate the mechanisms of high salt in disease risk, showing that it primes a specific activation state of macrophages.</div> <div itemprodp="datePublished">Sat Aug 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25848866"> <div itemprop="name">Rapid linkage of innate immunological signals to adaptive immunity by the brain-fat axis.</div> </a> <div itemprop="about">Nature immunology</div> <div itemprop="author">Kim MS,Yan J,Wu W,Zhang G,Zhang Y,Cai D</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate the role of the brain in innate immunological signals, showing rapid linkage of innate signals and adaptive immunity by the brain-fat axis.</div> <div itemprodp="datePublished">Fri May 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26621452"> <div itemprop="name">IKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Pallangyo CK,Ziegler PK,Greten FR</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to highlight an unexpected tumor suppressive function of IKKβ/NF-κB in CAFs linked to HGF release.</div> <div itemprodp="datePublished">Mon Dec 14 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25851535"> <div itemprop="name">ADAP and SKAP55 deficiency suppresses PD-1 expression in CD8+ cytotoxic T lymphocytes for enhanced anti-tumor immunotherapy.</div> </a> <div itemprop="about">EMBO molecular medicine</div> <div itemprop="author">Li C,Li W,Xiao J,Jiao S,Teng F,Xue S,Zhang C,Sheng C,Leng Q,Rudd CE,Wei B,Wang H</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate the effects of the ADAP-SKAP55 signaling module on cytotoxicity, PD-1 expression, and anti-tumour immunity.</div> <div itemprodp="datePublished">Mon Jun 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25385367"> <div itemprop="name">Developmental endothelial locus-1 is a homeostatic factor in the central nervous system limiting neuroinflammation and demyelination.</div> </a> <div itemprop="about">Molecular psychiatry</div> <div itemprop="author">Choi EY,Lim JH,Neuwirth A,Economopoulou M,Chatzigeorgiou A,Chung KJ,Bittner S,Lee SH,Langer H,Samus M,Kim H,Cho GS,Ziemssen T,Bdeir K,Chavakis E,Koh JY,Boon L,Hosur K,Bornstein SR,Meuth SG,Hajishengallis G,Chavakis T</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to provide mechanistic underpinnings for the previous implication of Del-1 as a candidate MS susceptibility gene.</div> <div itemprodp="datePublished">Wed Jul 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25941359"> <div itemprop="name">Interleukin-6/interleukin-21 signaling axis is critical in the pathogenesis of pulmonary arterial hypertension.</div> </a> <div itemprop="about">Proceedings of the National Academy of Sciences of the United States of America</div> <div itemprop="author">Hashimoto-Kataoka T,Hosen N,Sonobe T,Arita Y,Yasui T,Masaki T,Minami M,Inagaki T,Miyagawa S,Sawa Y,Murakami M,Kumanogoh A,Yamauchi-Takihara K,Okumura M,Kishimoto T,Komuro I,Shirai M,Sakata Y,Nakaoka Y</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to suggest that IL-21 promotes PAH in association with M2 macrophage polarisation, downstream of IL-6-signalling.</div> <div itemprodp="datePublished">Tue May 19 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26196182"> <div itemprop="name">Effects of growth arrest and DNA damage-inducible protein 34 (GADD34) on inflammation-induced colon cancer in mice.</div> </a> <div itemprop="about">British journal of cancer</div> <div itemprop="author">Tanaka Y,Ito S,Oshino R,Chen N,Nishio N,Isobe K</div> <div itemprop="description">17-4801 was used in Immunofluorescence to investigate how GADD34 up-regulated pro-inflammatory mediator production, leading to a higher tumour burden following AOM/DSS treatment.</div> <div itemprodp="datePublished">Tue Aug 11 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25336167"> <div itemprop="name">Conditional IL-4/IL-13-deficient mice reveal a critical role of innate immune cells for protective immunity against gastrointestinal helminths.</div> </a> <div itemprop="about">Mucosal immunology</div> <div itemprop="author">Oeser K,Schwartz C,Voehringer D</div> <div itemprop="description">17-4801 was used in Immunohistochemistry to compare the immune response to Nippostrongylus brasiliensis in wild-type, T cell-specific interleukin (IL)-4/IL-13-deficient and general IL-4/IL-13-deficient mice.</div> <div itemprodp="datePublished">Fri May 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25673700"> <div itemprop="name">Inflammatory monocytes recruited to the liver within 24 hours after virus-induced inflammation resemble Kupffer cells but are functionally distinct.</div> </a> <div itemprop="about">Journal of virology</div> <div itemprop="author">Movita D,van de Garde MD,Biesta P,Kreefft K,Haagmans B,Zuniga E,Herschke F,De Jonghe S,Janssen HL,Gama L,Boonstra A,Vanwolleghem T</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to demonstrate the enormous functional and genetic plasticity of monocytes infiltrating the liver after inflammation.</div> <div itemprodp="datePublished">Fri May 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27119106"> <div itemprop="name">Intratumoral INF-γ triggers an antiviral state in GL261 tumor cells: a major hurdle to overcome for oncolytic vaccinia virus therapy of cancer.</div> </a> <div itemprop="about">Molecular therapy oncolytics</div> <div itemprop="author">Kober C,Weibel S,Rohn S,Kirscher L,Szalay AA</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to identify microenvironmental factors, which may be decisive for failure or success of oncolytic VACV therapy.</div> <div itemprodp="datePublished">Wed Apr 27 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25348518"> <div itemprop="name">Anti-alpha-toxin monoclonal antibody and antibiotic combination therapy improves disease outcome and accelerates healing in a Staphylococcus aureus dermonecrosis model.</div> </a> <div itemprop="about">Antimicrobial agents and chemotherapy</div> <div itemprop="author">Hilliard JJ,Datta V,Tkaczyk C,Hamilton M,Sadowska A,Jones-Nelson O,O'Day T,Weiss WJ,Szarka S,Nguyen V,Prokai L,Suzich J,Stover CK,Sellman BR</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to characterise MEDI4893* and its therapeutic activity in a dermonecrosis model, showing that MEDI4893* and antibiotic combination therapy improves disease outcome.</div> <div itemprodp="datePublished">Thu Jan 01 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25857553"> <div itemprop="name">Quantifying progression and regression of thrombotic risk in experimental atherosclerosis.</div> </a> <div itemprop="about">FASEB journal : official publication of the Federation of American Societies for Experimental Biology</div> <div itemprop="author">Palekar RU,Jallouk AP,Goette MJ,Chen J,Myerson JW,Allen JS,Akk A,Yang L,Tu Y,Miller MJ,Pham CT,Wickline SA,Pan H</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to suggest that excessive permeability to PFC-NP may indicate prothrombotic risk in damaged atherosclerotic vasculature, which resolves within weeks after dietary therapy.</div> <div itemprodp="datePublished">Wed Jul 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25616357"> <div itemprop="name">Acid sphingomyelinase inhibition protects mice from lung edema and lethal Staphylococcus aureus sepsis.</div> </a> <div itemprop="about">Journal of molecular medicine (Berlin, Germany)</div> <div itemprop="author">Peng H,Li C,Kadow S,Henry BD,Steinmann J,Becker KA,Riehle A,Beckmann N,Wilker B,Li PL,Pritts T,Edwards MJ,Zhang Y,Gulbins E,Grassmé H</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate the role of the mammalian acid sphingomyelinase (Asm)/ceramide system in the development of lung edema caused by S. aureus.</div> <div itemprodp="datePublished">Mon Jun 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25404358"> <div itemprop="name">A novel flow cytometric method to assess inflammasome formation.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Sester DP,Thygesen SJ,Sagulenko V,Vajjhala PR,Cridland JA,Vitak N,Chen KW,Osborne GW,Schroder K,Stacey KJ</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to develop an assay for inflammasome formation, time of flight inflammasome evaluation.</div> <div itemprodp="datePublished">Thu Jan 01 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25825443"> <div itemprop="name">Newly recruited CD11b+, GR-1+, Ly6C(high) myeloid cells augment tumor-associated immunosuppression immediately following the therapeutic administration of oncolytic reovirus.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Clements DR,Sterea AM,Kim Y,Helson E,Dean CA,Nunokawa A,Coyle KM,Sharif T,Marcato P,Gujar SA,Lee PW</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to demonstrate that reovirus augments tumour-associated immunosuppression immediately following its therapeutic administration.</div> <div itemprodp="datePublished">Fri May 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26240279"> <div itemprop="name">Immunosuppression-Independent Role of Regulatory T Cells against Hypertension-Driven Renal Dysfunctions.</div> </a> <div itemprop="about">Molecular and cellular biology</div> <div itemprop="author">Fabbiano S,Menacho-Márquez M,Robles-Valero J,Pericacho M,Matesanz-Marín A,García-Macías C,Sevilla MA,Montero MJ,Alarcón B,López-Novoa JM,Martín P,Bustelo XR</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to determine that TREG cells constitute a first protective barrier against hypertension-driven tissue fibrosis.</div> <div itemprodp="datePublished">Thu Oct 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26151355"> <div itemprop="name">Toll-Like Receptor 4 Is an Essential Upstream Regulator of On-Time Parturition and Perinatal Viability in Mice.</div> </a> <div itemprop="about">Endocrinology</div> <div itemprop="author">Wahid HH,Dorian CL,Chin PY,Hutchinson MR,Rice KC,Olson DM,Moldenhauer LM,Robertson SA</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to describe TLR4-mediated regulation of the inflammatory response acting to drive uterine activation and control the timing of labour.</div> <div itemprodp="datePublished">Thu Oct 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26503169"> <div itemprop="name">Numb is required to prevent p53-dependent senescence following skeletal muscle injury.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Le Roux I,Konge J,Le Cam L,Flamant P,Tajbakhsh S</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to provide insights into the mechanisms regulating senescence in regenerating muscle.</div> <div itemprodp="datePublished">Tue Oct 27 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25724068"> <div itemprop="name">The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Sag D,Cekic C,Wu R,Linden J,Hedrick CC</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to demonstrate that the absence of ABCG1 inhibits tumour growth through modulation of macrophage function within the tumour.</div> <div itemprodp="datePublished">Fri Feb 27 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26611836"> <div itemprop="name">The NLRP3 inflammasome is critically involved in the development of bronchopulmonary dysplasia.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Liao J,Kapadia VS,Brown LS,Cheong N,Longoria C,Mija D,Ramgopal M,Mirpuri J,McCurnin DC,Savani RC</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to monitor the ratio of IL1β:IL1ra within tracheal aspirates from preterm infants during the development of bronchopulmonary dysplasia.</div> <div itemprodp="datePublished">Fri Nov 27 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26675186"> <div itemprop="name">Virulence-Dependent Alterations in the Kinetics of Immune Cells during Pulmonary Infection by Mycobacterium tuberculosis.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Kim WS,Kim JS,Cha SB,Han SJ,Kim H,Kwon KW,Kim SJ,Eum SY,Cho SN,Shin SJ</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to compare the bacterial burden, inflammation and kinetics of immune cells during aerogenic infection in the lung between laboratory-adapted strains (Mtb H37Rv and H37Ra) and Mtb K strain.</div> <div itemprodp="datePublished">Mon Jun 27 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26259611"> <div itemprop="name">CD300f immunoreceptor contributes to peripheral nerve regeneration by the modulation of macrophage inflammatory phenotype.</div> </a> <div itemprop="about">Journal of neuroinflammation</div> <div itemprop="author">Peluffo H,Solari-Saquieres P,Negro-Demontel ML,Francos-Quijorna I,Navarro X,López-Vales R,Sayós J,Lago N</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to show that the pair CD300f ligand is implicated in Wallerian degeneration and nerve regeneration by modulating both the influx and phenotype of macrophages.</div> <div itemprodp="datePublished">Wed Aug 12 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25793264"> <div itemprop="name">CoREST1 promotes tumor formation and tumor stroma interactions in a mouse model of breast cancer.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Mazumdar S,Arendt LM,Phillips S,Sedic M,Kuperwasser C,Gill G</div> <div itemprop="description">17-4801 was used in Immunofluorescence to investigate the tumourigenic mechanism of action of the co-repressor CoREST1.</div> <div itemprodp="datePublished">Tue Feb 09 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26147219"> <div itemprop="name">Ubiquitous Over-Expression of Chromatin Remodeling Factor SRG3 Ameliorates the T Cell-Mediated Exacerbation of EAE by Modulating the Phenotypes of both Dendritic Cells and Macrophages.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Lee SW,Park HJ,Jeon SH,Lee C,Seong RH,Park SH,Hong S</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate the role of a SWI3-related gene in experimental autoimmune encephalomyelitis development.</div> <div itemprodp="datePublished">Mon Apr 11 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26599547"> <div itemprop="name">Glycoprotein Nonmetastatic Melanoma B (Gpnmb)-Positive Macrophages Contribute to the Balance between Fibrosis and Fibrolysis during the Repair of Acute Liver Injury in Mice.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Kumagai K,Tabu K,Sasaki F,Takami Y,Morinaga Y,Mawatari S,Hashimoto S,Tanoue S,Kanmura S,Tamai T,Moriuchi A,Uto H,Tsubouchi H,Ido A</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to identify the immune cells which respond to acute liver injury and assess their contribution to the repair process.</div> <div itemprodp="datePublished">Mon Jun 20 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26632270"> <div itemprop="name">CX3CR1 deficiency promotes muscle repair and regeneration by enhancing macrophage ApoE production.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Arnold L,Perrin H,de Chanville CB,Saclier M,Hermand P,Poupel L,Guyon E,Licata F,Carpentier W,Vilar J,Mounier R,Chazaud B,Benhabiles N,Boissonnas A,Combadiere B,Combadiere C</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to show that CX3CR1 deficiency promotes muscle repair and rescues Ccl2-/- mice from impaired muscle regeneration through altering macrophage function.</div> <div itemprodp="datePublished">Thu Dec 03 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26324256"> <div itemprop="name">Sphingosine 1-Phosphate Receptor 2 and 3 Mediate Bone Marrow-Derived Monocyte/Macrophage Motility in Cholestatic Liver Injury in Mice.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Yang L,Han Z,Tian L,Mai P,Zhang Y,Wang L,Li L</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to evaluate the effects of S1P on bone marrow-derived monocyte/macrophage migration in mouse models of cholestatic liver injury, and characterise underlying signalling pathways.</div> <div itemprodp="datePublished">Tue Sep 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25043024"> <div itemprop="name">Functional polarization of tumour-associated macrophages by tumour-derived lactic acid.</div> </a> <div itemprop="about">Nature</div> <div itemprop="author">Colegio OR,Chu NQ,Szabo AL,Chu T,Rhebergen AM,Jairam V,Cyrus N,Brokowski CE,Eisenbarth SC,Phillips GM,Cline GW,Phillips AJ,Medzhitov R</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to demonstrate that tumour-cell-derived lactic acid has an important signalling role in the induction of tumour-associated macrophage polarization.</div> <div itemprodp="datePublished">Thu Sep 25 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24743146"> <div itemprop="name">Monocytes expressing CX3CR1 orchestrate the development of vincristine-induced pain.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Old EA,Nadkarni S,Grist J,Gentry C,Bevan S,Kim KW,Mogg AJ,Perretti M,Malcangio M</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to delineate a pathway for pain that is induced by the chemotherapeutic drug vincristine sulphate.</div> <div itemprodp="datePublished">Thu May 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24821912"> <div itemprop="name">12-Hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2 receptor.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Liu M,Saeki K,Matsunobu T,Okuno T,Koga T,Sugimoto Y,Yokoyama C,Nakamizo S,Kabashima K,Narumiya S,Shimizu T,Yokomizo T</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to demonstrate the potential use of BLT2 agonists as therapeutic agents to accelerate wound healing.</div> <div itemprodp="datePublished">Mon Jun 02 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25049337"> <div itemprop="name">18-HEPE, an n-3 fatty acid metabolite released by macrophages, prevents pressure overload-induced maladaptive cardiac remodeling.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Endo J,Sano M,Isobe Y,Fukuda K,Kang JX,Arai H,Arita M</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to study the ability of an eicosapentaenoic acid metabolite to inhibit macrophage-mediated proinflammatory activation of cardiac fibroblasts.</div> <div itemprodp="datePublished">Mon Jul 28 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25378478"> <div itemprop="name">The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells.</div> </a> <div itemprop="about">The EMBO journal</div> <div itemprop="author">Jurkin J,Henkel T,Nielsen AF,Minnich M,Popow J,Kaufmann T,Heindl K,Hoffmann T,Busslinger M,Martinez J</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate the mammalian ligase required for cleavage of XBP1, showing that tRNA ligase complex mediates splicing of XBP1 mRNA.</div> <div itemprodp="datePublished">Wed Dec 17 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24572573"> <div itemprop="name">Mapping the innate signaling cascade essential for cytokine storm during influenza virus infection.</div> </a> <div itemprop="about">Proceedings of the National Academy of Sciences of the United States of America</div> <div itemprop="author">Teijaro JR,Walsh KB,Rice S,Rosen H,Oldstone MB</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to show that sphingosine-1-phosphate-1 receptor agonist treatment suppresses global cytokine amplification during influenza virus infection.</div> <div itemprodp="datePublished">Tue Mar 11 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25210785"> <div itemprop="name">Age-dependent enterocyte invasion and microcolony formation by Salmonella.</div> </a> <div itemprop="about">PLoS pathogens</div> <div itemprop="author">Zhang K,Dupont A,Torow N,Gohde F,Leschner S,Lienenklaus S,Weiss S,Brinkmann MM,Kühnel M,Hensel M,Fulde M,Hornef MW</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to provide important insight in the early steps of Salmonella infection in vivo.</div> <div itemprodp="datePublished">Mon Sep 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25166617"> <div itemprop="name">TLR2 signaling decreases transmission of Streptococcus pneumoniae by limiting bacterial shedding in an infant mouse Influenza A co-infection model.</div> </a> <div itemprop="about">PLoS pathogens</div> <div itemprop="author">Richard AL,Siegel SJ,Erikson J,Weiser JN</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to suggest that the innate immune response to influenza virus promotes bacterial shedding.</div> <div itemprodp="datePublished">Fri Aug 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24453977"> <div itemprop="name">Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection.</div> </a> <div itemprop="about">PLoS pathogens</div> <div itemprop="author">Ataide MA,Andrade WA,Zamboni DS,Wang D,Souza Mdo C,Franklin BS,Elian S,Martins FS,Pereira D,Reed G,Fitzgerald KA,Golenbock DT,Gazzinelli RT</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to demonstrate that NLRP12/NLRP3-dependent activation of caspase-1 is likely to be a key event in mediating systemic production of IL-1β.</div> <div itemprodp="datePublished">Wed Jan 01 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24749068"> <div itemprop="name">CRIPTO/GRP78 signaling maintains fetal and adult mammary stem cells ex vivo.</div> </a> <div itemprop="about">Stem cell reports</div> <div itemprop="author">Spike BT,Kelber JA,Booker E,Kalathur M,Rodewald R,Lipianskaya J,La J,He M,Wright T,Klemke R,Wahl GM,Gray PC</div> <div itemprop="description">17-4801 was used in Immunofluorescence to identify the CRIPTO/GRP78 pathway as a developmentally conserved regulator of fetal and adult mammary stem cell behavior ex vivo.</div> <div itemprodp="datePublished">Tue Apr 08 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24858340"> <div itemprop="name">Induction of inducible nitric oxide synthase (iNOS) expression by oxLDL inhibits macrophage derived foam cell migration.</div> </a> <div itemprop="about">Atherosclerosis</div> <div itemprop="author">Huang H,Koelle P,Fendler M,Schröttle A,Czihal M,Hoffmann U,Conrad M,Kuhlencordt PJ</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate whether a reduction of inducible nitric oxide synthase-mediated oxidative stress remobilises macrophage-derived foam cells and may reverse atherosclerotic plaque formation.</div> <div itemprodp="datePublished">Tue Jul 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24016036"> <div itemprop="name">Development of a culture system to induce microglia-like cells from haematopoietic cells.</div> </a> <div itemprop="about">Neuropathology and applied neurobiology</div> <div itemprop="author">Noto D,Sakuma H,Takahashi K,Saika R,Saga R,Yamada M,Yamamura T,Miyake S</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to outline the conditions and factors necessary for the differentiation of microglia from progenitors.</div> <div itemprodp="datePublished">Wed Oct 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24604832"> <div itemprop="name">Tyrosine kinase 2 promotes sepsis-associated lethality by facilitating production of interleukin-27.</div> </a> <div itemprop="about">Journal of leukocyte biology</div> <div itemprop="author">Bosmann M,Strobl B,Kichler N,Rigler D,Grailer JJ,Pache F,Murray PJ,Müller M,Ward PA</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate factors governing the gene expression and release of IL-27.</div> <div itemprodp="datePublished">Tue Jul 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25365203"> <div itemprop="name">Exposure to cigarette smoke impacts myeloid-derived regulatory cell function and exacerbates airway hyper-responsiveness.</div> </a> <div itemprop="about">Laboratory investigation; a journal of technical methods and pathology</div> <div itemprop="author">Wang Y,Jin TH,Farhana A,Freeman J,Estell K,Zmijewski JW,Gaggar A,Thannickal VJ,Schwiebert LM,Steyn AJ,Deshane JS</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to assess the effects of exposing myeloid-derived regulatory cells to cigarette smoke on the production of nitric oxide.</div> <div itemprodp="datePublished">Mon Dec 01 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25225663"> <div itemprop="name">Resident alveolar macrophages suppress, whereas recruited monocytes promote, allergic lung inflammation in murine models of asthma.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Zasłona Z,Przybranowski S,Wilke C,van Rooijen N,Teitz-Tennenbaum S,Osterholzer JJ,Wilkinson JE,Moore BB,Peters-Golden M</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to demonstrate that rAMs dampen, whereas circulating monocytes promote, early events in allergic lung inflammation.</div> <div itemprodp="datePublished">Wed Oct 15 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25348624"> <div itemprop="name">Interruption of macrophage-derived IL-27(p28) production by IL-10 during sepsis requires STAT3 but not SOCS3.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Bosmann M,Russkamp NF,Strobl B,Roewe J,Balouzian L,Pache F,Radsak MP,van Rooijen N,Zetoune FS,Sarma JV,Núñez G,Müller M,Murray PJ,Ward PA</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to identify IL-10 as a critical suppressing factor for IL-27(p28) production during infection-associated inflammation.</div> <div itemprodp="datePublished">Mon Dec 01 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24850147"> <div itemprop="name">Increase in hypotonic stress-induced endocytic activity in macrophages via ClC-3.</div> </a> <div itemprop="about">Molecules and cells</div> <div itemprop="author">Yan Y,Ding Y,Ming B,Du W,Kong X,Tian L,Zheng F,Fang M,Tan Z,Gong F</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to elucidate whether and how hypotonicity affects immune cell function.</div> <div itemprodp="datePublished">Thu May 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24667630"> <div itemprop="name">Itraconazole, a commonly used antifungal, inhibits Fcγ receptor-mediated phagocytosis: alteration of Fcγ receptor glycosylation and gene expression.</div> </a> <div itemprop="about">Shock (Augusta, Ga.)</div> <div itemprop="author">Niño DF,Cauvi DM,De Maio A</div> <div itemprop="description">17-4801 was used in Immunocytochemistry-immunoflourescence to determine the effects of itraconazole on phagocytosis as a major function of macrophages.</div> <div itemprodp="datePublished">Tue Jul 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24667630"> <div itemprop="name">Itraconazole, a commonly used antifungal, inhibits Fcγ receptor-mediated phagocytosis: alteration of Fcγ receptor glycosylation and gene expression.</div> </a> <div itemprop="about">Shock (Augusta, Ga.)</div> <div itemprop="author">Niño DF,Cauvi DM,De Maio A</div> <div itemprop="description">17-4801 was used in Immunocytochemistry-immunoflourescence to determine the effects of itraconazole on phagocytosis as a major function of macrophages.</div> <div itemprodp="datePublished">Tue Jul 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25425969"> <div itemprop="name">Core needle biopsy of breast cancer tumors increases distant metastases in a mouse model.</div> </a> <div itemprop="about">Neoplasia (New York, N.Y.)</div> <div itemprop="author">Mathenge EG,Dean CA,Clements D,Vaghar-Kashani A,Photopoulos S,Coyle KM,Giacomantonio M,Malueth B,Nunokawa A,Jordan J,Lewis JD,Gujar SA,Marcato P,Lee PW,Giacomantonio CA</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to demonstrate that CNB creates an immunosuppressive tumour microenvironment, increases EMT, and facilitates release of circulating tumour cells, leading to increased metastases.</div> <div itemprodp="datePublished">Sat Nov 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25192716"> <div itemprop="name">The effect of CSF-1 administration on lung maturation in a mouse model of neonatal hyperoxia exposure.</div> </a> <div itemprop="about">Respiratory research</div> <div itemprop="author">Jones CV,Alikhan MA,O'Reilly M,Sozo F,Williams TM,Harding R,Jenkin G,Ricardo SD</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to examine the effect of CSF-1 administration on lung maturation in a mouse model of neonatal hyperoxia exposure.</div> <div itemprodp="datePublished">Sat Sep 06 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25266676"> <div itemprop="name">IKKα negatively regulates ASC-dependent inflammasome activation.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Martin BN,Wang C,Willette-Brown J,Herjan T,Gulen MF,Zhou H,Bulek K,Franchi L,Sato T,Alnemri ES,Narla G,Zhong XP,Thomas J,Klinman D,Fitzgerald KA,Karin M,Nuñez G,Dubyak G,Hu Y,Li X</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate the role of IκB kinase α in inflammasome activation, showing that it negatively regulates ASC-dependent activation.</div> <div itemprodp="datePublished">Tue Sep 30 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24466192"> <div itemprop="name">The monocyte to macrophage transition in the murine sterile wound.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Crane MJ,Daley JM,van Houtte O,Brancato SK,Henry WL,Albina JE</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to examine the origin of wound repair macrophages in sterile wounds using the subcutaneous polyvinyl alcohol sponge implantation model in mice.</div> <div itemprodp="datePublished">Tue Nov 04 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24551105"> <div itemprop="name">Dendritic cell subset distributions in the aorta in healthy and atherosclerotic mice.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Busch M,Westhofen TC,Koch M,Lutz MB,Zernecke A</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to perform a systematic analysis of dendritic cells and their accumulation characteristics during atherogenesis.</div> <div itemprodp="datePublished">Tue Oct 21 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24477292"> <div itemprop="name">p85α recruitment by the CD300f phosphatidylserine receptor mediates apoptotic cell clearance required for autoimmunity suppression.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Tian L,Choi SC,Murakami Y,Allen J,Morse HC,Qi CF,Krzewski K,Coligan JE</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to identify the mechanism and role of mouse CD300f in apoptotic cell phagocytosis and the maintenance of immune homeostasis.</div> <div itemprodp="datePublished">Mon Mar 07 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25213860"> <div itemprop="name">Mouse macrophages completely lacking Rho subfamily GTPases (RhoA, RhoB, and RhoC) have severe lamellipodial retraction defects, but robust chemotactic navigation and altered motility.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Königs V,Jennings R,Vogl T,Horsthemke M,Bachg AC,Xu Y,Grobe K,Brakebusch C,Schwab A,Bähler M,Knaus UG,Hanley PJ</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to demonstrate that Macrophages lacking Rho proteins migrate faster in vitro, which translates to more rapid in vivo monocyte/macrophage recruitment.</div> <div itemprodp="datePublished">Fri Oct 31 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23913046"> <div itemprop="name">Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens.</div> </a> <div itemprop="about">Nature immunology</div> <div itemprop="author">Satpathy AT,Briseño CG,Lee JS,Ng D,Manieri NA,Kc W,Wu X,Thomas SR,Lee WL,Turkoz M,McDonald KG,Meredith MM,Song C,Guidos CJ,Newberry RD,Ouyang W,Murphy TL,Stappenbeck TS,Gommerman JL,Nussenzweig MC,Colonna M,Kopan R,Murphy KM</div> <div itemprop="description">17-4801 was used in Immunofluorescence to elucidate the cellular source of essential IL-23 production required for the mucosal response to attaching-and-effacing bacterial infection.</div> <div itemprodp="datePublished">Sun Sep 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23291597"> <div itemprop="name">MHC class I-restricted myelin epitopes are cross-presented by Tip-DCs that promote determinant spreading to CD8⁺ T cells.</div> </a> <div itemprop="about">Nature immunology</div> <div itemprop="author">Ji Q,Castelli L,Goverman JM</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate the mechanisms underlying the role of CD8(+) T cells in the pathogenesis of multiple sclerosis.</div> <div itemprodp="datePublished">Fri Mar 01 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23435120"> <div itemprop="name">The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses.</div> </a> <div itemprop="about">Nature immunology</div> <div itemprop="author">Bell BD,Kitajima M,Larson RP,Stoklasek TA,Dang K,Sakamoto K,Wagner KU,Kaplan DH,Reizis B,Hennighausen L,Ziegler SF</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate how type-2 immunity is affected by STAT5 transcription factor in dendritic cells.</div> <div itemprodp="datePublished">Mon Apr 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23396050"> <div itemprop="name">miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis.</div> </a> <div itemprop="about">Nature cell biology</div> <div itemprop="author">Zhang Y,Yang P,Sun T,Li D,Xu X,Rui Y,Li C,Chong M,Ibrahim T,Mercatali L,Amadori D,Lu X,Xie D,Li QJ,Wang XF</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate the role of miR-126 and miR-126* in tumour progression.</div> <div itemprodp="datePublished">Fri Mar 01 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23257354"> <div itemprop="name">p62 links β-adrenergic input to mitochondrial function and thermogenesis.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Müller TD,Lee SJ,Jastroch M,Kabra D,Stemmer K,Aichler M,Abplanalp B,Ananthakrishnan G,Bhardwaj N,Collins S,Divanovic S,Endele M,Finan B,Gao Y,Habegger KM,Hembree J,Heppner KM,Hofmann S,Holland J,Küchler D,Kutschke M,Krishna R,Lehti M,Oelkrug R,Ottaway N,Perez-Tilve D,Raver C,Walch AK,Schriever SC,Speakman J,Tseng YH,Diaz-Meco M,Pfluger PT,Moscat J,Tschöp MH</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to elucidate the mechanisms underlying the role of the scaffold protein p62 in the control of metabolic homeostasis and obesity.</div> <div itemprodp="datePublished">Tue Jan 01 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24043764"> <div itemprop="name">Intestinal monocytes and macrophages are required for T cell polarization in response to Citrobacter rodentium.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Schreiber HA,Loschko J,Karssemeijer RA,Escolano A,Meredith MM,Mucida D,Guermonprez P,Nussenzweig MC</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to assess the effect of selective depletion of monocytes and macrophages on immune responses to a bacterial pathogen.</div> <div itemprodp="datePublished">Mon Sep 23 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23417922"> <div itemprop="name">Distinct functions of chemokine receptor axes in the atherogenic mobilization and recruitment of classical monocytes.</div> </a> <div itemprop="about">EMBO molecular medicine</div> <div itemprop="author">Soehnlein O,Drechsler M,Döring Y,Lievens D,Hartwig H,Kemmerich K,Ortega-Gómez A,Mandl M,Vijayan S,Projahn D,Garlichs CD,Koenen RR,Hristov M,Lutgens E,Zernecke A,Weber C</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate the differential role of classical and non-classical leukocytes in atheroprogression under high-fat diet, showing that CXCL1 and CCR1/CCR5 are important in the mobilisation and recruitment of classical monocytes in atheroprogression.</div> <div itemprodp="datePublished">Fri Mar 01 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23481323"> <div itemprop="name">VEGF blockade enables oncolytic cancer virotherapy in part by modulating intratumoral myeloid cells.</div> </a> <div itemprop="about">Molecular therapy : the journal of the American Society of Gene Therapy</div> <div itemprop="author">Currier MA,Eshun FK,Sholl A,Chernoguz A,Crawford K,Divanovic S,Boon L,Goins WF,Frischer JS,Collins MH,Leddon JL,Baird WH,Haseley A,Streby KA,Wang PY,Hendrickson BW,Brekken RA,Kaur B,Hildeman D,Cripe TP</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to demonstrate that systemic VEGF blockade significantly enhances oncolytic herpes simplex virus virotherapy for cancer by enhancing antiangiogenesis and modulating the innate cellular host response.</div> <div itemprodp="datePublished">Wed May 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23680658"> <div itemprop="name">Inhibition of Janus activated kinase-3 protects against myocardial ischemia and reperfusion injury in mice.</div> </a> <div itemprop="about">Experimental & molecular medicine</div> <div itemprop="author">Oh YB,Ahn M,Lee SM,Koh HW,Lee SH,Kim SH,Park BH</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to indicate that the inhibition of JAK3 may reduce inflammation-mediated apoptotic damage from myocardial I/R injury.</div> <div itemprodp="datePublished">Fri May 17 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23393393"> <div itemprop="name">CXCL12 promotes the stabilization of atherosclerotic lesions mediated by smooth muscle progenitor cells in Apoe-deficient mice.</div> </a> <div itemprop="about">Arteriosclerosis, thrombosis, and vascular biology</div> <div itemprop="author">Akhtar S,Gremse F,Kiessling F,Weber C,Schober A</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate the role of CXCL12 in the treatment of unstable atherosclerotic lesions.</div> <div itemprodp="datePublished">Mon Apr 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23423360"> <div itemprop="name">Lipidoid Nanoparticles Containing PD-L1 siRNA Delivered In Vivo Enter Kupffer Cells and Enhance NK and CD8(+) T Cell-mediated Hepatic Antiviral Immunity.</div> </a> <div itemprop="about">Molecular therapy. Nucleic acids</div> <div itemprop="author">Dolina JS,Sung SS,Novobrantseva TI,Nguyen TM,Hahn YS</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to demonstrate that PD-L1 knockdown on KCs is central in determining the outcome of liver viral infections, and they represent a new class of gene therapy.</div> <div itemprodp="datePublished">Tue Feb 19 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23211929"> <div itemprop="name">Role of NK cells in host defense against pulmonary type A Francisella tularensis infection.</div> </a> <div itemprop="about">Microbes and infection</div> <div itemprop="author">Schmitt DM,O'Dee DM,Brown MJ,Horzempa J,Russo BC,Morel PA,Nau GJ</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate role of NK cells against F.tularensis infection in vivo, with LVS-vaccinated murine hosts.</div> <div itemprodp="datePublished">Fri Mar 01 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23093804"> <div itemprop="name">Characterization and evaluation of a new oncolytic vaccinia virus strain LIVP6.1.1 for canine cancer therapy.</div> </a> <div itemprop="about">Bioengineered</div> <div itemprop="author">Gentschev I,Patil SS,Adelfinger M,Weibel S,Geissinger U,Frentzen A,Chen NG,Yu YA,Zhang Q,Ogilvie G,Szalay AA</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to demonstrate the efficacy of new VACV strain LIVP6.1.1 for canine cancer therapy.</div> <div itemprodp="datePublished">Wed Sep 04 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23766529"> <div itemprop="name">Kupffer cells potentiate liver sinusoidal endothelial cell injury in sepsis by ligating programmed cell death ligand-1.</div> </a> <div itemprop="about">Journal of leukocyte biology</div> <div itemprop="author">Hutchins NA,Wang F,Wang Y,Chung CS,Ayala A</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to study Kupffer cell-mediated potentiation of liver sinusoidal endothelial cell injury in sepsis by ligating programmed cell death ligand-1.</div> <div itemprodp="datePublished">Fri Nov 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23941876"> <div itemprop="name">Loss of CCR5 results in glucose intolerance in diet-induced obese mice.</div> </a> <div itemprop="about">American journal of physiology. Endocrinology and metabolism</div> <div itemprop="author">Kennedy A,Webb CD,Hill AA,Gruen ML,Jackson LG,Hasty AH</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to suggest that CCR5 deficiency impairs systemic glucose tolerance as well as adipose tissue and muscle insulin signaling.</div> <div itemprodp="datePublished">Tue Oct 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23670193"> <div itemprop="name">Critical roles of a dendritic cell subset expressing a chemokine receptor, XCR1.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Yamazaki C,Sugiyama M,Ohta T,Hemmi H,Hamada E,Sasaki I,Fukuda Y,Yano T,Nobuoka M,Hirashima T,Iizuka A,Sato K,Tanaka T,Hoshino K,Kaisho T</div> <div itemprop="description">17-4801 was used in Immunohistochemistry to track and ablate CD8α(+) dendritic cells in vivo to gather information on their function and behaviour.</div> <div itemprodp="datePublished">Sat Jun 15 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23197261"> <div itemprop="name">MARCO is required for TLR2- and Nod2-mediated responses to Streptococcus pneumoniae and clearance of pneumococcal colonization in the murine nasopharynx.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Dorrington MG,Roche AM,Chauvin SE,Tu Z,Mossman KL,Weiser JN,Bowdish DM</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to demonstrate that macrophage receptor with collagenous structure is an important component of anti-Streptococcus pneumoniae responses in the murine nasopharynx during colonisation.</div> <div itemprodp="datePublished">Tue Jan 01 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23359509"> <div itemprop="name">Hepatic stellate cells preferentially induce Foxp3+ regulatory T cells by production of retinoic acid.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Dunham RM,Thapa M,Velazquez VM,Elrod EJ,Denning TL,Pulendran B,Grakoui A</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to demonstrate a potential Treg enrichment role for hepatic stellate cells, supporting the tolerogenic nature of the liver.</div> <div itemprodp="datePublished">Fri Mar 01 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24014876"> <div itemprop="name">IFIT2 is an effector protein of type I IFN-mediated amplification of lipopolysaccharide (LPS)-induced TNF-α secretion and LPS-induced endotoxin shock.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Siegfried A,Berchtold S,Manncke B,Deuschle E,Reber J,Ott T,Weber M,Kalinke U,Hofer MJ,Hatesuer B,Schughart K,Gailus-Durner V,Fuchs H,Hrabe de Angelis M,Weber F,Hornef MW,Autenrieth IB,Bohn E</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to study the molecular mechanism by which type I interferon signalling amplifies the secretion of lipopolysaccharide-induced proinflammatory cytokines.</div> <div itemprodp="datePublished">Tue Oct 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23884140"> <div itemprop="name">Protective role of small pigment epithelium-derived factor (PEDF) peptide in diabetic renal injury.</div> </a> <div itemprop="about">American journal of physiology. Renal physiology</div> <div itemprop="author">Awad AS,Gao T,Gvritishvili A,You H,Liu Y,Cooper TK,Reeves WB,Tombran-Tink J</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to demonstrate the therapeutic potential of the pigment epithelium-derived factor fragment, P78-PEDF, for diabetic nephropathy.</div> <div itemprodp="datePublished">Sun Sep 15 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23918785"> <div itemprop="name">CD30 is required for activation of a unique subset of interleukin-17A-producing γδ T cells in innate immunity against Mycobacterium bovis Bacillus Calmette-Guerin infection.</div> </a> <div itemprop="about">Infection and immunity</div> <div itemprop="author">Guo Y,Sun X,Shibata K,Yamada H,Muta H,Podack ER,Yoshikai Y</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to demonstrate the involvement of CD30 signalling in the production of IL-17A by γδ T cells following BCG infection.</div> <div itemprodp="datePublished">Tue Oct 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23798541"> <div itemprop="name">Human and mouse macrophages collaborate with neutrophils to kill larval Strongyloides stercoralis.</div> </a> <div itemprop="about">Infection and immunity</div> <div itemprop="author">Bonne-Année S,Kerepesi LA,Hess JA,O'Connell AE,Lok JB,Nolan TJ,Abraham D</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to demonstrate a novel function by which alternatively activated macrophages control large extracellular parasites.</div> <div itemprodp="datePublished">Sun Sep 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23481504"> <div itemprop="name">CD11c+ alveolar macrophages are a source of IL-23 during lipopolysaccharide-induced acute lung injury.</div> </a> <div itemprop="about">Shock (Augusta, Ga.)</div> <div itemprop="author">Bosmann M,Grailer JJ,Russkamp NF,Ruemmler R,Zetoune FS,Sarma JV,Ward PA</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate the production and downstream effects of IL-23 using a mouse model of lipopolysaccharide-induced acute lung injury.</div> <div itemprodp="datePublished">Wed May 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23978258"> <div itemprop="name">Nitric oxide synthase expression correlates with death in an experimental mouse model of dengue with CNS involvement.</div> </a> <div itemprop="about">Virology journal</div> <div itemprop="author">de Souza KP,Silva EG,de Oliveira Rocha ES,Figueiredo LB,de Almeida-Leite CM,Arantes RM,de Assis Silva Gomes J,Ferreira GP,de Oliveira JG,Kroon EG,Campos MA</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to study how the neurovirulence of DENV 3 genotype I is associated with a deleterious role of NOS2 in the brain.</div> <div itemprodp="datePublished">Mon Aug 26 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23593521"> <div itemprop="name">High content analysis of primary macrophages hosting proliferating Leishmania amastigotes: application to anti-leishmanial drug discovery.</div> </a> <div itemprop="about">PLoS neglected tropical diseases</div> <div itemprop="author">Aulner N,Danckaert A,Rouault-Hardoin E,Desrivot J,Helynck O,Commere PH,Munier-Lehmann H,Späth GF,Shorte SL,Milon G,Prina E</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to develop a novel phenotypic screening assay using virulent Leishmania amastigotes growing inside primary macrophage to identify new chemical entities with bona fide drug potential.</div> <div itemprodp="datePublished">Thu Nov 14 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24339996"> <div itemprop="name">Nogo-receptor 1 deficiency has no influence on immune cell repertoire or function during experimental autoimmune encephalomyelitis.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Litwak SA,Payne NL,Campanale N,Ozturk E,Lee JY,Petratos S,Siatskas C,Bakhuraysah M,Bernard CC</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to demonstrate that NgR1 has little if any effects on the repertoire of immune cells, their activation and trafficking to the CNS.</div> <div itemprodp="datePublished">Fri Sep 19 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23720750"> <div itemprop="name">The cardioprotective protein apolipoprotein A1 promotes potent anti-tumorigenic effects.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Zamanian-Daryoush M,Lindner D,Tallant TC,Wang Z,Buffa J,Klipfell E,Parker Y,Hatala D,Parsons-Wingerter P,Rayman P,Yusufishaq MSS,Fisher EA,Smith JD,Finke J,DiDonato JA,Hazen SL</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to show that apolipoprotein A1 potently suppresses tumour growth and metastasis.</div> <div itemprodp="datePublished">Fri Jul 19 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24098366"> <div itemprop="name">Staphylococcus aureus alpha toxin suppresses effective innate and adaptive immune responses in a murine dermonecrosis model.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Tkaczyk C,Hamilton MM,Datta V,Yang XP,Hilliard JJ,Stephens GL,Sadowska A,Hua L,O'Day T,Suzich J,Stover CK,Sellman BR</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate the effect of alpha toxin on the immune response against soft tissue infections, showing that alpha toxin suppresses effective innate and adaptive immune responses.</div> <div itemprodp="datePublished">Mon Jun 23 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23991091"> <div itemprop="name">MiR-155 has a protective role in the development of non-alcoholic hepatosteatosis in mice.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Miller AM,Gilchrist DS,Nijjar J,Araldi E,Ramirez CM,Lavery CA,Fernández-Hernando C,McInnes IB,Kurowska-Stolarska M</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to indicate that miR-155 has an important role in regulating lipid metabolism in the liver, hence deregulation could lead to hepatic steatosis in those with diabetes.</div> <div itemprodp="datePublished">Sun Jun 15 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24204830"> <div itemprop="name">Chlamydia pneumoniae infection in mice induces chronic lung inflammation, iBALT formation, and fibrosis.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Jupelli M,Shimada K,Chiba N,Slepenkin A,Alsabeh R,Jones HD,Peterson E,Chen S,Arditi M,Crother TR</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate how chlamydia pneumoniae infection in mice induces chronic lung inflammation, iBALT formation, and fibrosis..</div> <div itemprodp="datePublished">Sat Aug 02 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23710206"> <div itemprop="name">Depletion of regulatory T cells in a mouse experimental glioma model through anti-CD25 treatment results in the infiltration of non-immunosuppressive myeloid cells in the brain.</div> </a> <div itemprop="about">Clinical & developmental immunology</div> <div itemprop="author">Maes W,Verschuere T,Van Hoylandt A,Boon L,Van Gool S</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to evaluate the local elimination of Tregs as a tool for augmentation of the antitumoural response.</div> <div itemprodp="datePublished">Tue Dec 10 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22902502"> <div itemprop="name">Rapid induction of inflammatory lipid mediators by the inflammasome in vivo.</div> </a> <div itemprop="about">Nature</div> <div itemprop="author">von Moltke J,Trinidad NJ,Moayeri M,Kintzer AF,Wang SB,van Rooijen N,Brown CR,Krantz BA,Leppla SH,Gronert K,Vance RE</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to identify novel caspase-1 protease functions in vivo using a strategy for cytosolic delivery of bacterial flagellin, a NAIP5 inflammasome ligand.</div> <div itemprodp="datePublished">Thu Oct 04 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22935568"> <div itemprop="name">Conditional targeting of tumor necrosis factor receptor-associated factor 6 reveals opposing functions of Toll-like receptor signaling in endothelial and myeloid cells in a mouse model of atherosclerosis.</div> </a> <div itemprop="about">Circulation</div> <div itemprop="author">Polykratis A,van Loo G,Xanthoulea S,Hellmich M,Pasparakis M</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to study how toll-like receptor-mediated TRAF6 signaling acts in endothelial cells to promote atherosclerosis but displays atheroprotective, antiinflammatory and prosurvival functions in myeloid cells.</div> <div itemprodp="datePublished">Tue Oct 02 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22615127"> <div itemprop="name">Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Satpathy AT,KC W,Albring JC,Edelson BT,Kretzer NM,Bhattacharya D,Murphy TL,Murphy KM</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to identify Zbtb46 as a transcription factor selectively expressed by classical DCs and their committed progenitors.</div> <div itemprodp="datePublished">Mon Jun 04 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22615130"> <div itemprop="name">Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Meredith MM,Liu K,Darrasse-Jeze G,Kamphorst AO,Schreiber HA,Guermonprez P,Idoyaga J,Cheong C,Yao KH,Niec RE,Nussenzweig MC</div> <div itemprop="description">17-4801 was used in Immunofluorescence to demonstrate that CD11c-expressing non-cDCs make significant contributions to initiating immunity to parasites and tumors.</div> <div itemprodp="datePublished">Mon Jun 04 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22383695"> <div itemprop="name">Pericyte TIMP3 and ADAMTS1 modulate vascular stability after kidney injury.</div> </a> <div itemprop="about">Journal of the American Society of Nephrology : JASN</div> <div itemprop="author">Schrimpf C,Xin C,Campanholle G,Gill SE,Stallcup W,Lin SL,Davis GE,Gharib SA,Humphreys BD,Duffield JS</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to study the functions for kidney pericytes in microvascular stability.</div> <div itemprodp="datePublished">Tue May 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22551807"> <div itemprop="name">Macrophage p38 mitogen-activated protein kinase activity regulates invariant natural killer T-cell responses during Borrelia burgdorferi infection.</div> </a> <div itemprop="about">The Journal of infectious diseases</div> <div itemprop="author">Hawley K,Navasa N,Olson CM,Bates TC,Garg R,Hedrick MN,Conze D,Rincón M,Anguita J</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to demonstrate that p38 mitogen-activated protein kinase-mediated responses are critical components to the immune response to Borrelia burgdorferi.</div> <div itemprodp="datePublished">Sun Jul 15 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22396652"> <div itemprop="name">A20 (Tnfaip3) deficiency in myeloid cells protects against influenza A virus infection.</div> </a> <div itemprop="about">PLoS pathogens</div> <div itemprop="author">Maelfait J,Roose K,Bogaert P,Sze M,Saelens X,Pasparakis M,Carpentier I,van Loo G,Beyaert R</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to examine the role of the ubiquitin-editing protein A20 in the innate immune responses to IAV and other viruses.</div> <div itemprodp="datePublished">Mon Jul 09 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22202675"> <div itemprop="name">Evidence for anti-inflammatory effects of C5a on the innate IL-17A/IL-23 axis.</div> </a> <div itemprop="about">FASEB journal : official publication of the Federation of American Societies for Experimental Biology</div> <div itemprop="author">Bosmann M,Sarma JV,Atefi G,Zetoune FS,Ward PA</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to demonstrate that C5a alters the production of cytokines to regulate inflammatory functions.</div> <div itemprodp="datePublished">Sun Apr 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22901752"> <div itemprop="name">The chymase mouse mast cell protease 4 degrades TNF, limits inflammation, and promotes survival in a model of sepsis.</div> </a> <div itemprop="about">The American journal of pathology</div> <div itemprop="author">Piliponsky AM,Chen CC,Rios EJ,Treuting PM,Lahiri A,Abrink M,Pejler G,Tsai M,Galli SJ</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate the role of chymase mouse mast cell protease 4 in a mouse model of sepsis.</div> <div itemprodp="datePublished">Sat Sep 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22888139"> <div itemprop="name">Protective role of commensals against Clostridium difficile infection via an IL-1β-mediated positive-feedback loop.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Hasegawa M,Kamada N,Jiao Y,Liu MZ,Núñez G,Inohara N</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to reveal a crucial role for translocated commensals in the recruitment of neutrophils to the C. difficile infected intestine.</div> <div itemprodp="datePublished">Sat Sep 15 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23045616"> <div itemprop="name">Evaluation of recombinant Leishmania polyprotein plus glucopyranosyl lipid A stable emulsion vaccines against sand fly-transmitted Leishmania major in C57BL/6 mice.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Peters NC,Bertholet S,Lawyer PG,Charmoy M,Romano A,Ribeiro-Gomes FL,Stamper LW,Sacks DL</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to assess the immunity generated by recombinant Leishmania polyprotein with GLA vaccination following challenge with L. major.</div> <div itemprodp="datePublished">Thu Nov 15 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22918642"> <div itemprop="name">Ethyl pyruvate ameliorates endotoxin-induced corneal inflammation.</div> </a> <div itemprop="about">Investigative ophthalmology & visual science</div> <div itemprop="author">Gupta D,Du Y,Piluek J,Jakub AM,Buela KA,Abbott A,Schuman JS,SundarRaj N</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to demonstrate that EP reduces LPS-induced inflammation in the cornea.</div> <div itemprodp="datePublished">Tue Sep 25 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22548913"> <div itemprop="name">Age-related defects in TLR2 signaling diminish the cytokine response by alveolar macrophages during murine pneumococcal pneumonia.</div> </a> <div itemprop="about">Experimental gerontology</div> <div itemprop="author">Boyd AR,Shivshankar P,Jiang S,Berton MT,Orihuela CJ</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate the extent of the impact of age-related deficiencies in Toll-like receptor function.</div> <div itemprodp="datePublished">Sun Jul 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23027530"> <div itemprop="name">Impaired innate immunity in mice deficient in interleukin-1 receptor-associated kinase 4 leads to defective type 1 T cell responses, B cell expansion, and enhanced susceptibility to infection with Toxoplasma gondii.</div> </a> <div itemprop="about">Infection and immunity</div> <div itemprop="author">Béla SR,Dutra MS,Mui E,Montpetit A,Oliveira FS,Oliveira SC,Arantes RM,Antonelli LR,McLeod R,Gazzinelli RT</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate the role of IRAK4 in Toxoplasma gondii infection, showing that deficiency leads to impaired innate immunity.</div> <div itemprodp="datePublished">Sat Dec 01 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22025508"> <div itemprop="name">MyD88-dependent recruitment of monocytes and dendritic cells required for protection from pulmonary Burkholderia mallei infection.</div> </a> <div itemprop="about">Infection and immunity</div> <div itemprop="author">Goodyear A,Troyer R,Bielefeldt-Ohmann H,Dow S</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to find that MyD88-/- mice were highly susceptible to pulmonary challenge with B. mallei and had significantly short survival times, increased bacterial burdens, and severe organ pathology compared to wild-type mice.</div> <div itemprodp="datePublished">Sun Jan 01 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23420085"> <div itemprop="name">Evaluation of in vitro macrophage differentiation during space flight.</div> </a> <div itemprop="about">Advances in space research : the official journal of the Committee on Space Research (COSPAR)</div> <div itemprop="author">Ortega MT,Lu N,Chapes SK</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to confirm that space flight can impact the in vitro development of macrophages from mouse bone marrow cells.</div> <div itemprodp="datePublished">Tue May 15 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22615950"> <div itemprop="name">Preclinical evaluation of oncolytic vaccinia virus for therapy of canine soft tissue sarcoma.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Gentschev I,Adelfinger M,Josupeit R,Rudolph S,Ehrig K,Donat U,Weibel S,Chen NG,Yu YA,Zhang Q,Heisig M,Thamm D,Stritzker J,Macneill A,Szalay AA</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to describe the establishment of an in vivo model of canine soft tissue sarcoma, allowing preclinical evaluation of oncolytic vaccinia virus for therapy.</div> <div itemprodp="datePublished">Thu Sep 20 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23166761"> <div itemprop="name">Dietary n-3 polyunsaturated fatty acids (PUFA) decrease obesity-associated Th17 cell-mediated inflammation during colitis.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Monk JM,Hou TY,Turk HF,Weeks B,Wu C,McMurray DN,Chapkin RS</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to monitor changes in immune cell subsets and inflammatory biomarker expression in a mouse model of concurrent obesity and colitis.</div> <div itemprodp="datePublished">Thu Jun 20 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22511975"> <div itemprop="name">The chemokine CXCL12 is essential for the clearance of the filaria Litomosoides sigmodontis in resistant mice.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Bouchery T,Dénécé G,Attout T,Ehrhardt K,Lhermitte-Vallarino N,Hachet-Haas M,Galzi JL,Brotin E,Bachelerie F,Gavotte L,Moulia C,Bain O,Martin C</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to study the dual effect of the CXCL12/CXCR4 axis on the L. sigmodontis life cycle: a host-cell restriction factor for infection, and as a growth factor for worms.</div> <div itemprodp="datePublished">Fri Dec 28 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23091626"> <div itemprop="name">Virotherapy of canine tumors with oncolytic vaccinia virus GLV-1h109 expressing an anti-VEGF single-chain antibody.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Patil SS,Gentschev I,Adelfinger M,Donat U,Hess M,Weibel S,Nolte I,Frentzen A,Szalay AA</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to analyse oncolytic vaccinia virus-mediated delivery and production of scAb GLAF-1 and the oncolytic and immunological effects on canine cancer.</div> <div itemprodp="datePublished">Thu Mar 28 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23316306"> <div itemprop="name">Deleterious effect of the IL-23/IL-17A axis and γδT cells on left ventricular remodeling after myocardial infarction.</div> </a> <div itemprop="about">Journal of the American Heart Association</div> <div itemprop="author">Yan X,Shichita T,Katsumata Y,Matsuhashi T,Ito H,Ito K,Anzai A,Endo J,Tamura Y,Kimura K,Fujita J,Shinmura K,Shen W,Yoshimura A,Fukuda K,Sano M</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to explore potential immune pathways involved in left ventricular remodelling as possible preventative therapeutic options.</div> <div itemprodp="datePublished">Mon Oct 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22768222"> <div itemprop="name">ATP release from dying autophagic cells and their phagocytosis are crucial for inflammasome activation in macrophages.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Ayna G,Krysko DV,Kaczmarek A,Petrovski G,Vandenabeele P,Fésüs L</div> <div itemprop="description">17-4801-82 was used in Flow Cytometry to demonstrate that NALP3 performs key upstream functions in inflammasome activation in mouse macrophages engulfing dying autophagic cells.</div> <div itemprodp="datePublished">Tue Nov 27 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24672679"> <div itemprop="name">Impact of enzymatic tissue disintegration on the level of surface molecule expression and immune cell function.</div> </a> <div itemprop="about">European journal of microbiology & immunology</div> <div itemprop="author">Autengruber A,Gereke M,Hansen G,Hennig C,Bruder D</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to indicate that enzymatic tissue disintegration can have profound effects on the expression of a variety of cell-surface molecules.</div> <div itemprodp="datePublished">Fri Jun 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22359597"> <div itemprop="name">Impact of macrophage inflammatory protein-1α deficiency on atherosclerotic lesion formation, hepatic steatosis, and adipose tissue expansion.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Kennedy A,Gruen ML,Gutierrez DA,Surmi BK,Orr JS,Webb CD,Hasty AH</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate the impact of macrophage inflammatory protein-1α deficiency on atherosclerotic lesion formation, hepatic steatosis, and adipose tissue expansion.</div> <div itemprodp="datePublished">Fri Aug 03 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21925319"> <div itemprop="name">Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection.</div> </a> <div itemprop="about">Cell</div> <div itemprop="author">Teijaro JR,Walsh KB,Cahalan S,Fremgen DM,Roberts E,Scott F,Martinborough E,Peach R,Oldstone MB,Rosen H</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to elucidate cellular and signalling mechanisms that are important in initiating cytokine storm.</div> <div itemprodp="datePublished">Fri Sep 16 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21562126"> <div itemprop="name">Galectin-9 attenuates acute lung injury by expanding CD14- plasmacytoid dendritic cell-like macrophages.</div> </a> <div itemprop="about">American journal of respiratory and critical care medicine</div> <div itemprop="author">Kojima K,Arikawa T,Saita N,Goto E,Tsumura S,Tanaka R,Masunaga A,Niki T,Oomizu S,Hirashima M,Kohrogi H</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to study how Gal-9 attenuates ALI by expanding CD14(-)CD11b(+)Gr-1(+) pDC-like macrophages by preferentially suppressing macrophage functions.</div> <div itemprodp="datePublished">Mon Aug 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21444914"> <div itemprop="name">Marginal zone macrophages suppress innate and adaptive immunity to apoptotic cells in the spleen.</div> </a> <div itemprop="about">Blood</div> <div itemprop="author">McGaha TL,Chen Y,Ravishankar B,van Rooijen N,Karlsson MC</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to support the hypothesis that MZMs are central in the clearance of apoptotic cells to minimize the immunogenicity of autoantigens.</div> <div itemprodp="datePublished">Thu May 19 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22056382"> <div itemprop="name">Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Maniati E,Bossard M,Cook N,Candido JB,Emami-Shahri N,Nedospasov SA,Balkwill FR,Tuveson DA,Hagemann T</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to reveal a novel interaction between oncogenic inflammation and the NF-κB pathway.</div> <div itemprodp="datePublished">Thu Dec 01 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22005305"> <div itemprop="name">Th2 signals induce epithelial injury in mice and are compatible with the biliary atresia phenotype.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Li J,Bessho K,Shivakumar P,Mourya R,Mohanty SK,Dos Santos JL,Miura IK,Porta G,Bezerra JA</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to assess whether Th1-independent mechanisms can activate effector cells to induce biliary atresia.</div> <div itemprodp="datePublished">Tue Nov 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22135456"> <div itemprop="name">The inflammatory cytokine IL-18 induces self-reactive innate antibody responses regulated by natural killer T cells.</div> </a> <div itemprop="about">Proceedings of the National Academy of Sciences of the United States of America</div> <div itemprop="author">Enoksson SL,Grasset EK,Hägglöf T,Mattsson N,Kaiser Y,Gabrielsson S,McGaha TL,Scheynius A,Karlsson MC</div> <div itemprop="description">17-4801 was used in Immunofluorescence to demonstrate a general NKT-mediated mechanism for the regulation of B-cell behaviour in inflammation and autoreactivity.</div> <div itemprodp="datePublished">Tue Dec 20 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21311566"> <div itemprop="name">TLR-2 and TLR-9 are sensors of apoptosis in a mouse model of doxorubicin-induced acute inflammation.</div> </a> <div itemprop="about">Cell death and differentiation</div> <div itemprop="author">Krysko DV,Kaczmarek A,Krysko O,Heyndrickx L,Woznicki J,Bogaert P,Cauwels A,Takahashi N,Magez S,Bachert C,Vandenabeele P</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to study the mechanisms used by the innate immune system to sense the immunogenic form of apoptosis induced by anthracycline antibiotics.</div> <div itemprodp="datePublished">Mon Aug 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21926276"> <div itemprop="name">Arginase-2 mediates diabetic renal injury.</div> </a> <div itemprop="about">Diabetes</div> <div itemprop="author">Morris SM,Gao T,Cooper TK,Kepka-Lenhart D,Awad AS</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to determine whether renal arginase activity or expression is increased in diabetes and whether arginase plays a role in development of diabetic nephropathy (DN), showing that arginase-2 mediates diabetic renal injury.</div> <div itemprodp="datePublished">Tue Nov 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21926275"> <div itemprop="name">Aberrant accumulation of undifferentiated myeloid cells in the adipose tissue of CCR2-deficient mice delays improvements in insulin sensitivity.</div> </a> <div itemprop="about">Diabetes</div> <div itemprop="author">Gutierrez DA,Kennedy A,Orr JS,Anderson EK,Webb CD,Gerrald WK,Hasty AH</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to determine adipose tissue-specific mechanisms for the delayed impact of CCR2 deficiency on insulin resistance.</div> <div itemprodp="datePublished">Tue Nov 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21253577"> <div itemprop="name">A helminth immunomodulator exploits host signaling events to regulate cytokine production in macrophages.</div> </a> <div itemprop="about">PLoS pathogens</div> <div itemprop="author">Klotz C,Ziegler T,Figueiredo AS,Rausch S,Hepworth MR,Obsivac N,Sers C,Lang R,Hammerstein P,Lucius R,Hartmann S</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to elucidate the signalling events in macrophages triggered by helminth immunomodulator cystatin, showing cytokine signalling is regulated in these macrophages.</div> <div itemprodp="datePublished">Thu Jan 06 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21898588"> <div itemprop="name">Lineage-committed osteoclast precursors circulate in blood and settle down into bone.</div> </a> <div itemprop="about">Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research</div> <div itemprop="author">Muto A,Mizoguchi T,Udagawa N,Ito S,Kawahara I,Abiko Y,Arai A,Harada S,Kobayashi Y,Nakamichi Y,Penninger JM,Noguchi T,Takahashi N</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to demonstrate that receptor activator of NF-κB-positive cells isolated from bone marrow and peripheral blood possess characteristics of quiescent osteoclast precursors in mice.</div> <div itemprodp="datePublished">Thu Dec 01 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21859896"> <div itemprop="name">MyD88-dependent production of IL-17F is modulated by the anaphylatoxin C5a via the Akt signaling pathway.</div> </a> <div itemprop="about">FASEB journal : official publication of the Federation of American Societies for Experimental Biology</div> <div itemprop="author">Bosmann M,Patel VR,Russkamp NF,Pache F,Zetoune FS,Sarma JV,Ward PA</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to study the expression and release of IL-17F and its regulation by the complement system.</div> <div itemprodp="datePublished">Thu Dec 01 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21421850"> <div itemprop="name">Clonal analysis reveals uniformity in the molecular profile and lineage potential of CCR9(+) and CCR9(-) thymus-settling progenitors.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Desanti GE,Jenkinson WE,Parnell SM,Boudil A,Gautreau-Rolland L,Eksteen B,Ezine S,Lane PJ,Jenkinson EJ,Anderson G</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to suggest that the earliest T cell progenitors represent a developmentally homogeneous progenitor pool that ensures the efficient generation of the first cohorts of T cells during thymus development.</div> <div itemprodp="datePublished">Sun May 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21411735"> <div itemprop="name">Nucleotide-binding oligomerization domain 1 mediates recognition of Clostridium difficile and induces neutrophil recruitment and protection against the pathogen.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Hasegawa M,Yamazaki T,Kamada N,Tawaratsumida K,Kim YG,Núñez G,Inohara N</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate how Nod1 regulates host susceptibility to C. difficile, and how Nod1-mediated neutrophil recruitment may be an important immune response against the pathogen.</div> <div itemprodp="datePublished">Fri Apr 15 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21572035"> <div itemprop="name">Genetic variation determines mast cell functions in experimental asthma.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Becker M,Reuter S,Friedrich P,Doener F,Michel A,Bopp T,Klein M,Schmitt E,Schild H,Radsak MP,Echtenacher B,Taube C,Stassen M</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate the role of mast cells in allergic asthma.</div> <div itemprodp="datePublished">Wed Jun 15 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21757190"> <div itemprop="name">Evaluation of macrophage plasticity in brown and white adipose tissue.</div> </a> <div itemprop="about">Cellular immunology</div> <div itemprop="author">Ortega MT,Xie L,Mora S,Chapes SK</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate the impact of white adipose tissue, brown adipose tissue and in vitro cultured adipocytes on C2D macrophage cell plasticity in different microenvironments.</div> <div itemprodp="datePublished">Fri Dec 09 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21880831"> <div itemprop="name">Monocyte/macrophage chemokine receptor CCR2 mediates diabetic renal injury.</div> </a> <div itemprop="about">American journal of physiology. Renal physiology</div> <div itemprop="author">Awad AS,Kinsey GR,Khutsishvili K,Gao T,Bolton WK,Okusa MD</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to study the mediation of diabetic renal injury by monocyte/macrophage chemokine receptor CCR2.</div> <div itemprodp="datePublished">Thu Dec 01 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21825059"> <div itemprop="name">Enhanced neutrophil longevity and recruitment contribute to the severity of oviduct pathology during Chlamydia muridarum infection.</div> </a> <div itemprop="about">Infection and immunity</div> <div itemprop="author">Frazer LC,O'Connell CM,Andrews CW,Zurenski MA,Darville T</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate the role of neutrophils in chlamydia-induced pathology.</div> <div itemprodp="datePublished">Sat Oct 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21149587"> <div itemprop="name">Interleukin-17 contributes to generation of Th1 immunity and neutrophil recruitment during Chlamydia muridarum genital tract infection but is not required for macrophage influx or normal resolution of infection.</div> </a> <div itemprop="about">Infection and immunity</div> <div itemprop="author">Scurlock AM,Frazer LC,Andrews CW,O'Connell CM,Foote IP,Bailey SL,Chandra-Kuntal K,Kolls JK,Darville T</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate the role of IL-17 during C. muridarum genital tract infection.</div> <div itemprodp="datePublished">Tue Mar 01 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21063239"> <div itemprop="name">Prolonged chemokine expression and excessive neutrophil infiltration in the lungs of burn-injured mice exposed to ethanol and pulmonary infection.</div> </a> <div itemprop="about">Shock (Augusta, Ga.)</div> <div itemprop="author">Murdoch EL,Karavitis J,Deburghgraeve C,Ramirez L,Kovacs EJ</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to examine the cellular composition at 24 and 48 h in the circulation and the alveoli of infected mice given alcohol and burn.</div> <div itemprodp="datePublished">Fri Apr 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21067780"> <div itemprop="name">Prevention of NKT cell activation accelerates cutaneous wound closure and alters local inflammatory signals.</div> </a> <div itemprop="about">The Journal of surgical research</div> <div itemprop="author">Schneider DF,Palmer JL,Tulley JM,Kovacs EJ,Gamelli RL,Faunce DE</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to explore the effects of purposefully inhibiting natural killer T cell activation on the response to injury.</div> <div itemprodp="datePublished">Tue Nov 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21155838"> <div itemprop="name">Accumulation of eosinophils in intestine-draining mesenteric lymph nodes occurs after Trichuris muris infection.</div> </a> <div itemprop="about">Parasite immunology</div> <div itemprop="author">Svensson M,Bell L,Little MC,DeSchoolmeester M,Locksley RM,Else KJ</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to study the accumulation of eosinophils in intestine-draining mesenteric lymph nodes following Trichuris muris infection.</div> <div itemprodp="datePublished">Sat Jan 01 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21779374"> <div itemprop="name">Efficient colonization and therapy of human hepatocellular carcinoma (HCC) using the oncolytic vaccinia virus strain GLV-1h68.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Gentschev I,Müller M,Adelfinger M,Weibel S,Grummt F,Zimmermann M,Bitzer M,Heisig M,Zhang Q,Yu YA,Chen NG,Stritzker J,Lauer UM,Szalay AA</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to demonstrate that the GLV-1h68 vaccinia virus may have an enormous potential for treatment of human hepatocellular carcinoma in man.</div> <div itemprodp="datePublished">Tue Nov 15 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21400678"> <div itemprop="name">Measurement of tumor cytolysis by macrophages.</div> </a> <div itemprop="about">Current protocols in immunology</div> <div itemprop="author">Escórcio-Correia M,Hagemann T</div> <div itemprop="description">17-4801-82 was used in Flow cytometry/Cell sorting to describe two different protocols for the measurement of tumor cytolysis by macrophages.</div> <div itemprodp="datePublished">Tue Feb 01 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20625006"> <div itemprop="name">Alternatively activated macrophages inhibit T-cell proliferation by Stat6-dependent expression of PD-L2.</div> </a> <div itemprop="about">Blood</div> <div itemprop="author">Huber S,Hoffmann R,Muskens F,Voehringer D</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to study how IL-4 induced the expression of PD-L2 on CAM, and LPS increased the expression of PD-L1 on alternatively activated macrophages.</div> <div itemprodp="datePublished">Thu Oct 28 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20338995"> <div itemprop="name">Activation of sphingosine-1-phosphate 1 receptor in the proximal tubule protects against ischemia-reperfusion injury.</div> </a> <div itemprop="about">Journal of the American Society of Nephrology : JASN</div> <div itemprop="author">Bajwa A,Jo SK,Ye H,Huang L,Dondeti KR,Rosin DL,Haase VH,Macdonald TL,Lynch KR,Okusa MD</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate the effects of sphingosine-1-phosphate receptor agonists on acute kidney injury.</div> <div itemprodp="datePublished">Tue Jun 01 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20035049"> <div itemprop="name">Mast cell-derived TNF can exacerbate mortality during severe bacterial infections in C57BL/6-KitW-sh/W-sh mice.</div> </a> <div itemprop="about">The American journal of pathology</div> <div itemprop="author">Piliponsky AM,Chen CC,Grimbaldeston MA,Burns-Guydish SM,Hardy J,Kalesnikoff J,Contag CH,Tsai M,Galli SJ</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate the roles of mast cells and their derived proteins in two models of severe bacterial infection.</div> <div itemprodp="datePublished">Mon Feb 01 00:00:00 EST 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20427766"> <div itemprop="name">Antigen-specific immunity and cross-priming by epithelial ovarian carcinoma-induced CD11b(+)Gr-1(+) cells.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Tomihara K,Guo M,Shin T,Sun X,Ludwig SM,Brumlik MJ,Zhang B,Curiel TJ,Shin T</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate CD11b(+)Gr-1(+) cells found in epithelial ovarian cancer-bearing mice, which are induced by ovarian cancer cells and undergo antigen-specific immunity and cross-priming.</div> <div itemprodp="datePublished">Tue Jun 01 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20720199"> <div itemprop="name">IFN regulatory factor 3 contributes to the host response during Pseudomonas aeruginosa lung infection in mice.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Carrigan SO,Junkins R,Yang YJ,Macneil A,Richardson C,Johnston B,Lin TJ</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate host defence mechanisms involved in P. aeruginosa lung infection.</div> <div itemprodp="datePublished">Wed Sep 15 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19931603"> <div itemprop="name">The role of damage associated molecular pattern molecules in acetaminophen-induced liver injury in mice.</div> </a> <div itemprop="about">Toxicology letters</div> <div itemprop="author">Martin-Murphy BV,Holt MP,Ju C</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to show that damage associated molecular pattern molecules released from damaged and necrotic hepatocytes may link the initial hepatocyte damage and the activation of innate immune cells following Acetaminophen-exposure.</div> <div itemprodp="datePublished">Mon Feb 15 00:00:00 EST 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19501588"> <div itemprop="name">Expression of the chemokine binding protein M3 promotes marked changes in the accumulation of specific leukocytes subsets within the intestine.</div> </a> <div itemprop="about">Gastroenterology</div> <div itemprop="author">Shang L,Thirunarayanan N,Viejo-Borbolla A,Martin AP,Bogunovic M,Marchesi F,Unkeless JC,Ho Y,Furtado GC,Alcami A,Merad M,Mayer L,Lira SA</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to study the importance of the chemokine binding protein M3 in enabling distribution of leukocytes throughout the intestine.</div> <div itemprodp="datePublished">Tue Sep 01 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19920349"> <div itemprop="name">An adventitial IL-6/MCP1 amplification loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Tieu BC,Lee C,Sun H,Lejeune W,Recinos A,Ju X,Spratt H,Guo DC,Milewicz D,Tilton RG,Brasier AR</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to identify a vascular inflammatory pathway that contributes to the development of cardiovascular disease.</div> <div itemprodp="datePublished">Tue Dec 01 00:00:00 EST 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19497969"> <div itemprop="name">Regulatory T cells suppress innate immunity in kidney ischemia-reperfusion injury.</div> </a> <div itemprop="about">Journal of the American Society of Nephrology : JASN</div> <div itemprop="author">Kinsey GR,Sharma R,Huang L,Li L,Vergis AL,Ye H,Ju ST,Okusa MD</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate whether the anti-inflammatory effects of CD4(+)CD25(+)FoxP3(+) Tregs protect against renal IRI.</div> <div itemprodp="datePublished">Sat Aug 01 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19543375"> <div itemprop="name">Vector transmission of leishmania abrogates vaccine-induced protective immunity.</div> </a> <div itemprop="about">PLoS pathogens</div> <div itemprop="author">Peters NC,Kimblin N,Secundino N,Kamhawi S,Lawyer P,Sacks DL</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to identify the critical immunological factors influencing vaccine efficacy following natural transmissions of Leishmania.</div> <div itemprodp="datePublished">Mon Jun 01 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19201847"> <div itemprop="name">Naive mouse macrophages become activated following recognition of L5178Y lymphoma cells via concurrent ligation of CD40, NKG2D, and CD18 molecules.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Buhtoiarov IN,Rakhmilevich AL,Lanier LL,Ranheim EA,Sondel PM</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate the mechanisms of tumour-macrophage interactions leading to macrophage activation, showing that activation follows ligation of CD40, NKG2D, and CD18 molecules.</div> <div itemprodp="datePublished">Sun Feb 15 00:00:00 EST 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19454670"> <div itemprop="name">Hypercostimulation through 4-1BB distorts homeostasis of immune cells.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Lee SW,Salek-Ardakani S,Mittler RS,Croft M</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate the potential side effects of immunotherapeutic strategies using Abs against costimulatory molecules.</div> <div itemprodp="datePublished">Mon Jun 01 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19812208"> <div itemprop="name">Resistance of human alveolar macrophages to Bacillus anthracis lethal toxin.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Wu W,Mehta H,Chakrabarty K,Booth JL,Duggan ES,Patel KB,Ballard JD,Coggeshall KM,Metcalf JP</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to study how mature and differentiated AM are relatively resistant to the effects of LT as compared with mouse RAW 264.7 macrophages.</div> <div itemprodp="datePublished">Sun Nov 01 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19812208"> <div itemprop="name">Resistance of human alveolar macrophages to Bacillus anthracis lethal toxin.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Wu W,Mehta H,Chakrabarty K,Booth JL,Duggan ES,Patel KB,Ballard JD,Coggeshall KM,Metcalf JP</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to study how mature and differentiated AM are relatively resistant to the effects of LT as compared with mouse RAW 264.7 macrophages.</div> <div itemprodp="datePublished">Sun Nov 01 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19923456"> <div itemprop="name">An innate response to allogeneic nonself mediated by monocytes.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Zecher D,van Rooijen N,Rothstein DM,Shlomchik WD,Lakkis FG</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate how innate immune system distinguishes self-tissues from those of other members of the same species.</div> <div itemprodp="datePublished">Tue Dec 15 00:00:00 EST 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19542426"> <div itemprop="name">Modulating the expression of IFN regulatory factor 8 alters the protumorigenic behavior of CD11b+Gr-1+ myeloid cells.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Stewart TJ,Liewehr DJ,Steinberg SM,Greeneltch KM,Abrams SI</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate the intrinsic molecular events that drive myeloid-derived suppressor cell protumorigenic behavior.</div> <div itemprodp="datePublished">Wed Jul 01 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19056998"> <div itemprop="name">Shifts in bone marrow cell phenotypes caused by spaceflight.</div> </a> <div itemprop="about">Journal of applied physiology (Bethesda, Md. : 1985)</div> <div itemprop="author">Ortega MT,Pecaut MJ,Gridley DS,Stodieck LS,Ferguson V,Chapes SK</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to determine how spaceflight affects differentiation of cells in the granulocytic lineage in mice.</div> <div itemprodp="datePublished">Sun Feb 01 00:00:00 EST 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19490833"> <div itemprop="name">Lymphocytes serve as a reservoir for Listeria monocytogenes growth during infection of mice.</div> </a> <div itemprop="about">Microbial pathogenesis</div> <div itemprop="author">McElroy DS,Ashley TJ,D'Orazio SE</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to demonstrate that intracellular L. monocytogenes can survive and multiply in vitro in a variety of transformed cell lines of lymphocytic origin.</div> <div itemprodp="datePublished">Wed Apr 01 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19771172"> <div itemprop="name">Interleukin-10 overexpression promotes Fas-ligand-dependent chronic macrophage-mediated demyelinating polyneuropathy.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Dace DS,Khan AA,Stark JL,Kelly J,Cross AH,Apte RS</div> <div itemprop="description">17-4801 was used in Immunohistochemistry on paraffin embedded tissues to investigate the conditions contributing to the development of CIDP and related conditions.</div> <div itemprodp="datePublished">Tue Sep 22 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18604213"> <div itemprop="name">Identification of regulatory functions for 4-1BB and 4-1BBL in myelopoiesis and the development of dendritic cells.</div> </a> <div itemprop="about">Nature immunology</div> <div itemprop="author">Lee SW,Park Y,So T,Kwon BS,Cheroutre H,Mittler RS,Croft M</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to show that the costimulatory molecule 4-1BB, and also its ligand 4-1BBL, is able to limit myelopoiesis and dendritic cell development.</div> <div itemprodp="datePublished">Fri Aug 01 00:00:00 EDT 2008</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18712788"> <div itemprop="name">Mechanism of T cell tolerance induction by murine hepatic Kupffer cells.</div> </a> <div itemprop="about">Hepatology (Baltimore, Md.)</div> <div itemprop="author">You Q,Cheng L,Kedl RM,Ju C</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to examine the ability of Kupffer cells to present antigens and to suppress T cell activation by splenic dendritic cells.</div> <div itemprodp="datePublished">Mon Sep 01 00:00:00 EDT 2008</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18337479"> <div itemprop="name">CXCL9, but not CXCL10, promotes CXCR3-dependent immune-mediated kidney disease.</div> </a> <div itemprop="about">Journal of the American Society of Nephrology : JASN</div> <div itemprop="author">Menke J,Zeller GC,Kikawada E,Means TK,Huang XR,Lan HY,Lu B,Farber J,Luster AD,Kelley VR</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to identify additional therapeutic chemokine targets for immune-mediated nephritis.</div> <div itemprodp="datePublished">Sun Jun 01 00:00:00 EDT 2008</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18297128"> <div itemprop="name">Diversity of interferon gamma and granulocyte-macrophage colony-stimulating factor in restoring immune dysfunction of dendritic cells and macrophages during polymicrobial sepsis.</div> </a> <div itemprop="about">Molecular medicine (Cambridge, Mass.)</div> <div itemprop="author">Flohé SB,Agrawal H,Flohé S,Rani M,Bangen JM,Schade FU</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to test potential immunomodulatory approaches to restore the function of dendritic cells and macrophages during polymicrobial sepsis.</div> <div itemprodp="datePublished">Mon Aug 11 00:00:00 EDT 2008</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18981160"> <div itemprop="name">Sunlight triggers cutaneous lupus through a CSF-1-dependent mechanism in MRL-Fas(lpr) mice.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Menke J,Hsu MY,Byrne KT,Lucas JA,Rabacal WA,Croker BP,Zong XH,Stanley ER,Kelley VR</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate the role of UVB in cutaneous lupus erythematosus, showing that UVB triggers it through a CSF-1-dependent, macrophage-mediated mechanism.</div> <div itemprodp="datePublished">Sat Nov 15 00:00:00 EST 2008</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18832705"> <div itemprop="name">NKG2D is critical for NK cell activation in host defense against Pseudomonas aeruginosa respiratory infection.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Wesselkamper SC,Eppert BL,Motz GT,Lau GW,Hassett DJ,Borchers MT</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate the cellular and molecular mechanisms of NKG2D-mediated clearance of P. aeruginosa.</div> <div itemprodp="datePublished">Wed Oct 15 00:00:00 EDT 2008</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18754853"> <div itemprop="name">G-CSF induction early in uropathogenic Escherichia coli infection of the urinary tract modulates host immunity.</div> </a> <div itemprop="about">Cellular microbiology</div> <div itemprop="author">Ingersoll MA,Kline KA,Nielsen HV,Hultgren SJ</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate the mechanism of recruitment of neutrophils to the bladder during urinary tract infection, showing that G-CSF induction early in infection modulates host immunity.</div> <div itemprodp="datePublished">Mon Dec 01 00:00:00 EST 2008</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18591227"> <div itemprop="name">Phenotypic switching in Cryptococcus neoformans contributes to virulence by changing the immunological host response.</div> </a> <div itemprop="about">Infection and immunity</div> <div itemprop="author">Guerrero A,Fries BC</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to compare survival rates and characterise the host responses of C. neoformans-resistant mice.</div> <div itemprodp="datePublished">Mon Sep 01 00:00:00 EDT 2008</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18505807"> <div itemprop="name">Hypercholesterolemia impairs immunity to tuberculosis.</div> </a> <div itemprop="about">Infection and immunity</div> <div itemprop="author">Martens GW,Arikan MC,Lee J,Ren F,Vallerskog T,Kornfeld H</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to show that ApoE(-/-) deficiency is associated with delayed expression of adaptive immunity to tuberculosis caused by elevated serum cholesterol.</div> <div itemprodp="datePublished">Fri Aug 01 00:00:00 EDT 2008</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/17585110"> <div itemprop="name">Tuberculosis susceptibility of diabetic mice.</div> </a> <div itemprop="about">American journal of respiratory cell and molecular biology</div> <div itemprop="author">Martens GW,Arikan MC,Lee J,Ren F,Greiner D,Kornfeld H</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to demonstrate that control of Mycobacterium tuberculosis infection is impaired by chronic diabetes.</div> <div itemprodp="datePublished">Thu Nov 01 00:00:00 EDT 2007</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/17130243"> <div itemprop="name">Murine CXCL14 is dispensable for dendritic cell function and localization within peripheral tissues.</div> </a> <div itemprop="about">Molecular and cellular biology</div> <div itemprop="author">Meuter S,Schaerli P,Roos RS,Brandau O,Bösl MR,von Andrian UH,Moser B</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate the process of dendritic cell recruitment to peripheral tissues, showing that murine CXCL14 is dispensable for dendritic cell function and localisation.</div> <div itemprodp="datePublished">Thu Feb 01 00:00:00 EST 2007</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/16782035"> <div itemprop="name">Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment.</div> </a> <div itemprop="about">Immunity</div> <div itemprop="author">Nagai Y,Garrett KP,Ohta S,Bahrun U,Kouro T,Akira S,Takatsu K,Kincade PW</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to investigate the expression of toll-like receptors on different hematopoietic stem cells and the mechanism by which they stimulate innate immune system replenishment.</div> <div itemprodp="datePublished">Thu Jun 01 00:00:00 EDT 2006</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/16403835"> <div itemprop="name">Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney.</div> </a> <div itemprop="about">American journal of physiology. Renal physiology</div> <div itemprop="author">Awad AS,Ye H,Huang L,Li L,Foss FW,Macdonald TL,Lynch KR,Okusa MD</div> <div itemprop="description">17-4801 was used in Flow cytometry/Cell sorting to demonstrate that the protective effect of FTY-720 is due primarily to activation of S1P1 receptors.</div> <div itemprodp="datePublished">Thu Jun 01 00:00:00 EDT 2006</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/16037409"> <div itemprop="name">Macrophages in the murine pancreas and their involvement in fetal endocrine development in vitro.</div> </a> <div itemprop="about">Journal of leukocyte biology</div> <div itemprop="author">Geutskens SB,Otonkoski T,Pulkkinen MA,Drexhage HA,Leenen PJ</div> <div itemprop="description"></div> <div itemprodp="datePublished">Sat Oct 01 00:00:00 EDT 2005</div> </div> </noscript> </div> <div class="border-bottom"></div> <div class="product-bioinformatics-details"> <div class="container"> <h2 class="pdp-sub-heading">Bioinformatics</h2> <div class="row"> <div class="large-span-6 medium-span-12 small-span-12"> <div class="bioinformatics-wrapper"> <p class="bioinformatics-detail-section" id="proteinContent"> <strong>Protein Aliases:</strong> Adhesion G protein-coupled receptor E1; Cell surface glycoprotein F4/80; EGF-like module containing, mucin-like, hormone receptor-like sequence 1; EGF-like module receptor 1; EGF-like module-containing mucin-like hormone receptor-like 1; EMR1 hormone receptor; lymphocyte antigen 71 </p> <p class="view-buttons" id="ptnViewBtn" ng-class="$ctrl.bioContentLines('proteinContent', 'ptnViewBtn')"> <a id="proteinViewMoreBtn" ng-click="$ctrl.bioContentViewMore('proteinViewMoreBtn', 'proteinViewLessBtn', 'proteinContent')"> View more </a> <a id="proteinViewLessBtn" ng-click="$ctrl.bioContentViewLess('proteinViewLessBtn', 'proteinViewMoreBtn', 'proteinContent')"> View less </a> </p> </div> <div class="bioinformatics-wrapper"> <p class="bioinformatics-detail-section" id="geneContent"> <strong>Gene Aliases:</strong> Adgre1; DD7A5-7; EGF-TM7; Emr1; F4/80; Gpf480; Ly71; TM7LN3 </p> <p class="view-buttons" id="geneViewBtn" ng-class="$ctrl.bioContentLines('geneContent', 'geneViewBtn')"> <a id="geneViewMoreBtn" ng-click="$ctrl.bioContentViewMore('geneViewMoreBtn', 'geneViewLessBtn', 'geneContent')"> View more </a> <a id="geneViewLessBtn" ng-click="$ctrl.bioContentViewLess('geneViewLessBtn', 'geneViewMoreBtn', 'geneContent')"> View less </a> </p> </div> <div class="bioinformatics-wrapper"> <p class="bioinformatics-detail-section" id="unitProContent"> <strong>UniProt ID:</strong> <a href="http://www.uniprot.org/uniprot/Q61549" target="_blank">(Mouse) Q61549</a> </p> <p class="view-buttons" id="unitViewBtn" ng-class="$ctrl.bioContentLines('unitProContent', 'unitViewBtn')"> <a id="unitProViewMoreBtn" ng-click="$ctrl.bioContentViewMore('unitProViewMoreBtn', 'unitProViewLessBtn', 'unitProContent')"> View more </a> <a id="unitProViewLessBtn" ng-click="$ctrl.bioContentViewLess('unitProViewLessBtn', 'unitProViewMoreBtn', 'unitProContent')"> View less </a> </p> </div> <div class="bioinformatics-wrapper"> <p class="bioinformatics-detail-section" id="entrezContent"> <strong>Entrez Gene ID:</strong> <a href="http://www.ncbi.nlm.nih.gov/gene?term=13733" target="_blank">(Mouse) 13733</a> </p> <p class="view-buttons" id="etzViewBtn" ng-class="$ctrl.bioContentLines('entrezContent', 'etzViewBtn')"> <a id="entrezViewMoreBtn" ng-click="$ctrl.bioContentViewMore('entrezViewMoreBtn', 'entrezViewLessBtn', 'entrezContent')"> View more </a> <a id="entrezViewLessBtn" ng-click="$ctrl.bioContentViewLess('entrezViewLessBtn', 'entrezViewMoreBtn', 'entrezContent')"> View less </a> </p> </div> </div> <div class="large-span-6 medium-span-12 small-span-12"> <div class="accordion" id="accordion-bioinformatics"> <div class="accordion-group"> <div class="accordion-heading"> <a class="accordion-toggle" data-toggle="collapse" data-parent="#accordion2" target="_self" href="#collapseOne"> Function(s) </a> </div> <div id="collapseOne" class="accordion-body collapse"> <div class="accordion-inner"> <a class="icon" href="/antibody/primary/panther/signal transducer activity"> signal transducer activity </a> <a class="icon" href="/antibody/primary/panther/transmembrane signaling receptor activity"> transmembrane signaling receptor activity </a> <a class="icon" href="/antibody/primary/panther/G-protein coupled receptor activity"> G-protein coupled receptor activity </a> <a class="icon" href="/antibody/primary/panther/calcium ion binding"> calcium ion binding </a> <a class="icon" href="/antibody/primary/panther/G-protein coupled receptor"> G-protein coupled receptor </a> </div> </div> </div> <div class="accordion-group"> <div class="accordion-heading"> <a class="accordion-toggle" data-toggle="collapse" data-parent="#accordion2" target="_self" href="#collapseTwo"> Process(es) </a> </div> <div id="collapseTwo" class="accordion-body collapse"> <div class="accordion-inner"> <a class="icon" href="/antibody/primary/panther/signal transduction"> signal transduction </a> <a class="icon" href="/antibody/primary/panther/cell surface receptor signaling pathway"> cell surface receptor signaling pathway </a> <a class="icon" href="/antibody/primary/panther/G-protein coupled receptor signaling pathway"> G-protein coupled receptor signaling pathway </a> </div> </div> </div> </div> </div> </div> </div> </div> <div class="recommended-products border-bottom hidden">  It has to be done as per old AB suggested Products section. </div> <script type="text/javascript" src="/order/genome-database/assets/core/js/magellanCore.js?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"></script> <script type="text/javascript"> $m.addPerformanceMark('abPDPScripts:loadBegin'); </script> <script type="text/javascript" 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THERMO_FISHER.pdp.productOrderComponent.productDesc = 'Description: The BM8 monoclonal antibody reacts with mouse F4/80 antigen, an approximately 160 kDa surface receptor. It belongs to the EGF-TM7 family of proteins. As such it contains seven EGF-like domains on its extracellular N-terminus, seven transmembrane spanning sequences, and an intracellular C-terminal domain showing homology to other TM7 superfamily members. The F4/80 antigen is expressed by a majority of mature macrophages and is one of the best markers for this population of cells. However, other cell types, such as peritoneal eosinophils, Langerhans cells, and some other dendritic cell subtypes, have been reported to express this antigen as well. Expression of F4/80 commences during early myeloid development in vivo and can be upregulated on BM cells stimulated in vitro with M-CSF. Some populations of macrophages, especially in the lymphoid microenvironment, may be devoid of F4/80.<br /><br />Applications Reported: BM8 has been reported for use in flow cytometric analysis.<br /><br />Applications Tested: The BM8 antibody has been tested by flow cytometric analysis of mouse resident peritoneal exudate cells. This can be used at less than or equal to 2 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. 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