Multiple cells of origin in cholangiocarcinoma underlie biological, epidemiological and clinical heterogeneity

<!DOCTYPE html> <html> <head> <meta charset="utf-8" /> <meta name="viewport" content="width=device-width, initial-scale=1.0" http-equiv="Content-Type"> <meta name="title" content="Multiple cells of origin in cholangiocarcinoma underlie biological, epidemiological and clinical heterogeneity" /> <meta name="description" content="Multiple cells of origin in cholangiocarcinoma underlie biological, epidemiological and clinical heterogeneity" /> <meta property="og:url" content="https://www.wjgnet.com/1948-5204/full/v4/i5/WJGO-4-94-g001.htm" /> <meta property="og:type" content="Website" /> <meta property="og:title" content="Multiple cells of origin in cholangiocarcinoma underlie biological, epidemiological and clinical heterogeneity" /> <meta property="og:description" content="Multiple cells of origin in cholangiocarcinoma underlie biological, epidemiological and clinical heterogeneity" /> <meta property="og:image" content="" /> <meta name="twitter:card" content="summary_large_image" /> <meta 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Inc." /> <meta name="dc.date" content="May 15, 2012" /> <meta name="dc.identifier" content="doi:10.4251/wjgo.v4.i5.94" /> <meta name="dc.creator" content="Vincenzo Cardinale" /> <meta name="dc.creator" content="Guido Carpino" /> <meta name="dc.creator" content="Lola Reid" /> <meta name="dc.creator" content="Eugenio Gaudio" /> <meta name="dc.creator" content="Domenico Alvaro" /> <meta name="citation_journal_title" content="World Journal of Gastrointestinal Oncology" /> <meta name="citation_authors" content="Vincenzo Cardinale, Guido Carpino, Lola Reid, Eugenio Gaudio, Domenico Alvaro" /> <meta name="citation_title" content="Multiple cells of origin in cholangiocarcinoma underlie biological, epidemiological and clinical heterogeneity" /> <meta name="citation_publication_date" content="May 15, 2012" /> <meta name="citation_volume" content="4" /> <meta name="citation_issue" content="5" /> <meta name="citation_firstpage" content="94" /> <meta name="citation_lastpage" content="102" /> <meta 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<ul> <li><a href="/1948-5204/abstract/v4/i5/94.htm" target="_blank">Abstract</a></li> <li><a href="https://www.f6publishing.com/forms/main/DownLoadFile.aspx?Type=Digital&TypeId=1&id=10.4251%2fwjgo.v4.i5.94&FilePath=648F621617AE5F6FE240E6454CEF1DE190FF28440EF5968CCB020A39D4A7B0DEADFF139CAB9DCEF57AEEF8FF2801256CE4B24C2F27C37172" target="_blank">Full Article with Cover (PDF)</a></li> <li><a href="https://www.wjgnet.com/1948-5204/full/v4/i5/94.htm" target="_blank">Full Article (HTML)</a></li> <li><a href="http://www.ncbi.nlm.nih.gov/pmc/articles/22645632" target="_blank">PubMed Central</a></li> <li><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=PMC3360107" target="_blank">PubMed</a></li> <li><a href="http://dx.doi.org/10.4251/wjgo.v4.i5.94" target="_blank">CrossRef</a></li> <li><a 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this article </span> </div> </div> <div class="sectioncontent cl" id="cimg5div" style="display:none;"> <span id="citation_html">Cardinale V, Carpino G, Reid L, Gaudio E, Alvaro D. Multiple cells of origin in cholangiocarcinoma underlie biological, epidemiological and clinical heterogeneity. <em>World J Gastrointest Oncol</em> 2012; 4(5): 94-102 [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/PMC3360107' target='_blank'>PMC3360107</a> DOI: <a href='https://dx.doi.org/10.4251/wjgo.v4.i5.94' target='_blank'>10.4251/wjgo.v4.i5.94</a>]</span> </div> </div> <div class="left-collapse cl"> <div class="sectiontitle cl" onclick="ShowDetail('cimg6');"> <div class="sectionimg fl"> <img style="border:0;" alt="" id="cimg6" src="https://www.f6publishing.com/contents/images/collapsed_yes.gif" /> </div> <div class="sectiontext fl"> <span> Corresponding Author of This Article </span> </div> </div> <div class="sectioncontent cl" id="cimg6div" style="display:none;"> <span>Domenico Alvaro, Professor, Division of Gastroenterology, Department of Medico-Surgical Sciences and Biotechnologies, Polo Pontino, Fondazione Eleonora Lorillard Spencer Cenci, Sapienza University of Rome, Viale dell'Universita 37, 00185 Rome, Italy. <email>domenico.alvaro@uniroma1.it</email></span> </div> </div> <div class="left-collapse cl"> <div class="sectiontitle cl" onclick="ShowDetail('cimg11');"> <div class="sectionimg fl"> <img style="border:0;" alt="" id="cimg11" src="https://www.f6publishing.com/contents/images/collapsed_yes.gif" /> </div> <div class="sectiontext fl"> <span> Article-Type of This Article </span> </div> </div> <div class="sectioncontent cl" id="cimg11div" style="display:none;"> <span>Editorial</span> </div> </div> <div class="left-collapse cl"> <div class="sectiontitle cl" onclick="ShowDetail('cimg12');"> <div class="sectionimg fl"> <img style="border:0;" alt="" id="cimg12" src="https://www.f6publishing.com/contents/images/collapsed_yes.gif" /> </div> <div class="sectiontext fl"> <span> Open-Access Policy of This Article </span> </div> </div> <div class="sectioncontent cl" id="cimg12div" style="display:none;"> <span>This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. 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Downloads for This Article </span> </div> </div> <div class="sectioncontent cl"> <ul> <li><span>Total Article Views (7575)</span></li> </ul> <div> <div class="infotitle"> All Articles published online </div> <div class="articlestatis"> <link rel="stylesheet" href="/DXR.axd?r=1_74,1_68,1_69,1_70,10_9-2NNPn" /> <script id="dxis_571550021" src="/DXR.axd?r=1_11,1_252,1_12,1_23,1_64,1_13,1_14,1_15,1_16,1_20,10_0,10_1,10_2,10_3,10_4,1_21,1_22,17_0,17_22-8NNPn"></script> <div style="padding:0;margin:0;margin-bottom:5px;"> <input type="hidden"/><script id="dxss_1978049490">  </script><div id="chartc2e0c578-883c-42da-9d56-af5c873a0111" onmousemove="ASPx.chartMouseMove(event, 'chartc2e0c578-883c-42da-9d56-af5c873a0111')" onclick="ASPx.chartClick(event, 'chartc2e0c578-883c-42da-9d56-af5c873a0111')" style="height:300px;width:215px;"> <img id="chartc2e0c578-883c-42da-9d56-af5c873a0111_IMG" src="/DXB.axd?DXCache=6d3989bd-57e8-0307-f2f7-2bb1ec4a1319" alt="The chart showing PDF series, HTML series, 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style="width:1px;text-align:right;"><span class="dx-vam"> </span></td> </tr> </table></td><td id="gvStatis82e7dc49-a2a7-4262-b3b3-ee34bd7e2a08_col1" class="dxgvHeader" style="border-top-width:0px;border-left-width:0px;border-right-width:0px;"><table style="width:100%;"> <tr> <td>Count</td><td style="width:1px;text-align:right;"><span class="dx-vam"> </span></td> </tr> </table></td> </tr><tr id="gvStatis82e7dc49-a2a7-4262-b3b3-ee34bd7e2a08_DXDataRow0" class="dxgvDataRow"> <td class="dxgv">PDF</td><td class="dxgv dx-ar" style="border-right-width:0px;">690</td> </tr><tr id="gvStatis82e7dc49-a2a7-4262-b3b3-ee34bd7e2a08_DXDataRow1" class="dxgvDataRow"> <td class="dxgv">HTML</td><td class="dxgv dx-ar" style="border-right-width:0px;">6021</td> </tr><tr id="gvStatis82e7dc49-a2a7-4262-b3b3-ee34bd7e2a08_DXDataRow2" class="dxgvDataRow"> <td class="dxgv">Figures (1-1)</td><td class="dxgv dx-ar" style="border-right-width:0px;">617</td> </tr><tr id="gvStatis82e7dc49-a2a7-4262-b3b3-ee34bd7e2a08_DXDataRow3" class="dxgvDataRow"> <td class="dxgv">Tables (1-1)</td><td class="dxgv dx-ar" style="border-right-width:0px;">247</td> </tr><tr id="gvStatis82e7dc49-a2a7-4262-b3b3-ee34bd7e2a08_DXFooterRow" class="dxgvFooter"> <td class="dxgv" style="border-bottom-width:0px;"> </td><td class="dxgv" style="text-align:Right;border-right-width:0px;border-bottom-width:0px;">Sum=7575</td> </tr> </table><table id="gvStatis82e7dc49-a2a7-4262-b3b3-ee34bd7e2a08_LP" class="dxgvLoadingPanel" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_89-2NNPn" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="gvStatis82e7dc49-a2a7-4262-b3b3-ee34bd7e2a08_TL">Loading…</span></td> </tr> </table><div id="gvStatis82e7dc49-a2a7-4262-b3b3-ee34bd7e2a08_LD" class="dxgvLoadingDiv" 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src="/DXR.axd?r=1_89-2NNPn" alt="Hide" style="position:absolute;visibility:hidden;top:-100px;" /></td> </tr> </table><script id="dxss_482584382">  </script> </div> </div> </div> <div> May 15, 2012 (publication date) through Feb 21, 2025 </div> </div> </div> <div class="left-collapse cl"> <div class="sectiontitle cl"> <div class="sectiontext fl"> <span> Times Cited of This Article </span> </div> </div> <div class="sectioncontent cl"> <ul> <li><a class="tocLink" href="/1948-5204/CitedArticles?id=10.4251%2fwjgo.v4.i5.94" target="_blank">Times Cited (87)</a></li> </ul> </div> </div> <div class="left-collapse cl"> <div class="sectiontitle cl"> <div class="sectiontext fl"> <span> Journal Information of This Article </span> </div> </div> <div class="sectioncontent cl"> <div class="infotitle"> Publication Name </div> <div class="infocontent"> <i>World Journal of Gastrointestinal Oncology</i> </div> <div class="infotitle"> ISSN </div> <div class="infocontent"> 1948-5204 </div> <div class="infotitle"> Publisher of This Article </div> <div class="infocontent"> Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA </div> <br /> </div> </div> </div> <div class="infopart fr"> <link rel="stylesheet" href="/DXR.axd?r=1_74,1_68,1_69,1_70,1_73,1_210,1_207-2NNPn" /><link rel="stylesheet" href="/DXR.axd?r=1_209,1_206,1_254,1_253,1_84-2NNPn" /> <script id="dxis_1324860310" 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Oncol. </span><span>May 15, 2012; </span><span>4(5): 94-102</span><br /> <span>Published online May 15, 2012. doi: <a href="http://dx.doi.org/10.4251/wjgo.v4.i5.94" target="_self">10.4251/wjgo.v4.i5.94</a></span> </div> </div> <div class="article-item-container article-item-fig" id="$[FigureId]"> <div class="article-item-image-container"> <a href="https://f6publishing.blob.core.windows.net/1769f4f4-3bdb-44b4-9903-33d46b0df367/WJGO-4-94-g001.jpg" target="_blank"> <img src="https://f6publishing.blob.core.windows.net/1769f4f4-3bdb-44b4-9903-33d46b0df367/WJGO-4-94-g001.jpg" class="graphic" alt="Figure 1" border="0" title="Figure 1" /> </a> <div class="image-btn-container"> <a href="https://f6publishing.blob.core.windows.net/1769f4f4-3bdb-44b4-9903-33d46b0df367/WJGO-4-94-g001.jpg" class="image-btn" target="_blank">Full Size Figure</a> <a href="https://www.f6publishing.com/forms/main/downloadfile.aspx?download=true&FilePath=648F621617AE5F6FE240E6454CEF1DE190FF28440EF5968CCB020A39D4A7B0DEADFF139CAB9DCEF53A0B9DAA2598B7256A8F8411E17547EB" class="image-btn" target="_blank">Download Figure</a> </div> </div> <div> <b>Figure 1 Schematic diagram of the cell-lineages-of-origin and relative cells-of-origin within and of the related cholangiocarcinoma subtypes.</b> <span> Cells belonging from human hepatic stem cell (hHpSC) lineage or from biliary tree stem/progenitor cell (BTSC) lineage are retained cells of origin of different intrahepatic (IH)- and extrahepatic (EH)-cholangiocarcinoma (CCA) subtypes recently described[<a class="refcontent" href="http://#b17" data-jats-ref-type="bibr" data-jats-rid="B17">17</a>,<a class="refcontent" href="http://#b18" data-jats-ref-type="bibr" data-jats-rid="B18">18</a>,<a class="refcontent" href="http://#b58" data-jats-ref-type="bibr" data-jats-rid="B58">58</a>]. Histology, grossly, the main clinical features and the associated diseases of the CCAs arising within the two cell lineages are showed respectively. HCC: Hepatocarcinoma; CLC: Cholangiolocarcinoma. </span> </div> </div> <div id="dpcitation" class="article-abstract-item"> <hr /> <ul> <li> <b>Citation: </b>Cardinale V, Carpino G, Reid L, Gaudio E, Alvaro D. Multiple cells of origin in cholangiocarcinoma underlie biological, epidemiological and clinical heterogeneity. <i>World J Gastrointest Oncol</i> 2012; 4(5): 94-102 </li> <li> <b>URL: </b><a href="https://www.wjgnet.com/1948-5204/full/v4/i5/94.htm" target="_self">https://www.wjgnet.com/1948-5204/full/v4/i5/94.htm</a> </li> <li> <b>DOI: </b><a href="https://dx.doi.org/10.4251/wjgo.v4.i5.94" target="_self">https://dx.doi.org/10.4251/wjgo.v4.i5.94</a> </li> </ul> <hr/> </div> </div> <div id="videoPopup_PW-1" class="dxpcLite dxpclW" style="height:600px;width:720px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div 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Multiple cells of origin in cholangiocarcinoma underlie biological, epidemiological and clinical heterogeneity