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Simple Plex Human Caspase-1 Assay Cartridge (2nd Gen) (SPCKB-PS-003613)
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<li> Products </li> <li> <a href="/t/caspase-1">Caspase-1</a> </li> <li> <a href="/t/caspase-1/simple-plex">Caspase-1 Simple Plex</a> </li> <li> Simple Plex Human Caspase-1 Cartridge (2nd Gen) (SPCKB-PS-003613) </li> </ol> </nav> </div> </div> </div> </div> <div class="row"> <div class="col-md-12"> <main> <section class="section"> <div> <div id="block-bio-techne-global-content" class="system_main_block"> <div class="top_region"><div class="o___product-summary mb-3"><div id="pp-page-title-brand-wrapper"> <div id="header-subheader" data-section="section-base--header-subheader"> <div class="row" id="pp-page-title-brand-wrapper"> <div class="col-lg-9 col-md-12"> <h1 class="font-weight-bold"> Simple Plex Human Caspase-1 Cartridge (2nd Gen) </h1> <h2 class="font-weight-normal h4"> ProteinSimple, part of Bio-Techne <span id="product-code"> | Catalog # <span class="font-weight-bold">SPCKB-PS-003613</span> </span> </h2> <div id="pp-reviews-citations-row"> <div id="header_left" class="row"> <div class="col-auto d-flex align-self-center"> <div> <a href="#product-documents" class="datasheet_link product-datasheets" rel="nofollow">Product Datasheet / COA</a> </div> </div> </div> </div> <div id="new_version_available"> </div> <div class="row mb-2" id="extended-description"> <div class="col-md-10 extended-description-wrapper" id="extended-description-wrapper"> Simple Plex Human Caspase-1 assay kit for use on Ella instrument. Contains cartridge, sample diluent SD13, and wash buffer. </div> </div> </div> <div class="col-lg-3 col-md-12"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/logos/bio-techne-proteinsimple.svg" alt="ProteinSimple, part of Bio-Techne" class="d-flex h-100 w-100"> </div> </div> </div> </div> <div id="product_alerts_wrapper"><article class="product-data-wrapper"> </article> </div> </div> <div class="row border-top mb-2" id="images_atc_orderinfo_wrapper"><div class="col-xl-9 mt-2" id="image_atc_keydetails_wrapper"><div class="row" id="image_atc_wrapper"><div class="col-xl-4 order-xl-first" id="image_wrapper"><article class="product-data-wrapper"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="proteinsimple"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="https://resources.bio-techne.com/images/products/spckb-ps-003613_simple-plex-cartridge-kit-for-16-samples-1-analyte-for-use-with-human-plasma-serum-279202117726.png" alt="Simple Plex Cartridge Kit for 16 samples, 1 analyte for use with Human Plasma / Serum." title="Simple Plex Cartridge Kit for 16 samples, 1 analyte for use with Human Plasma / Serum." data-caption="" data-badges="" data-application="N/A" width="250" height="250" fetchpriority=high as=image class="search_result_thumbnail_image" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> <span class="image-count-text align-middle">(3)</span> </div> </div> </div> <i data-src="https://resources.bio-techne.com/images/products/spckb-ps-003613_simple-plex-cartridge-kit-for-16-samples-1-analyte-for-use-with-human-plasma-serum-11102021154118.jpg" data-alt="Human Caspase-1 Simple Plex Assay Standard Curve" title="Human Caspase-1 Simple Plex Assay Standard Curve" data-caption="" data-badges="" data-application="N/A" data-width="250" data-height="250" class="none"></i> <i data-src="https://resources.bio-techne.com/images/products/spckb-ps-003613_simple-plex-cartridge-kit-for-16-samples-1-analyte-for-use-with-human-plasma-serum-11102021154323.jpg" data-alt="Human Caspase-1 Simple Plex Assay Linearity" title="Human Caspase-1 Simple Plex Assay Linearity" data-caption="" data-badges="" data-application="N/A" data-width="250" data-height="250" class="none"></i> </div> </div> </article> </div> <div class="col-xl-8" id="atc_wrapper"><article class="product-data-wrapper position-relative align-vertical"> <div id="order_detail_wrapper" class="order_detail_wrapper"> <h3>Customize Your Simple Plex Cartridge</h3> <p>Create your custom Simple Plex cartridge for up to 8 targets. Choose from more than 250 targets across multiple species.</p> <hr class="a___border-dashed my-4"> <div class="text-right mb-2"> <a class="btn btn-primary text-white" href="/resources/simple-plex-panel-builder"> Build My Cartridge </a> </div> </div> </article> </div> </div> <div class="row datapoint_list border-top" id="key_details_wrapper"><div class="col-xl-12 mt-2" id="key_details_col_wrapper"></div> </div> </div> <div class="col-xl-3 mt-2" id="orderinfo_guarantee_wrapper"><div id="order_information_wrapper"> <div id="product_shipping_block_wrapper" data-brand="proteinsimple" data-shipping="" data-source="ep-data" data-sub_category_id="136"> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"><span class="sr-only">Loading...</span></div> </div> </div> <div id="product_ads_wrapper"><article class="product-data-wrapper"> </article> </div> </div> </div> <div class="datapoint_list" id="key_details"><h3>Key Product Details</h3></div> <div class="mt-2" id="prod_key_details_footnote"><p><!-- x-tinymce/html -->*The Sample Volume represented is based on the amount of sample incorporated into the reaction after taking into account the assay’s minimum required dilution for a given matrix. Serial dilution may be necessary to achieve some of the final sample volumes represented.</p> </div> <div id="view_technical_detail_links"><div class="text-center"> <a id="view_technical" href="#about-data-tab-tab">View Full Technical Details for Simple Plex Human Caspase-1 Cartridge (2nd Gen)</a> </div> </div> </div> <div class="tab-content rounded-bottom shadow border-0 mb-3"><div id="about-data-tab-tab"></div> <ul class="nav nav-tabs nav-fill " id="productTab" role="tablist"> <li class="nav-item"> <a class="nav-link active" id="technical-data-tab-tab" href="#technical-data-tab" data-toggle="tab" role="tab" aria-controls="region-5791588863627" aria-selected="true" >Technical Data</a> </li> <li class="nav-item"> <a class="nav-link" id="citations-tab-tab" href="#citations-tab" data-toggle="tab" role="tab" aria-controls="region-8571587488941" aria-selected="false" >Citations</a> </li> </ul> <div class="tab-content rounded-bottom border-left border-right border-bottom mb-3" id="ProductTabContent"><div class="tab-pane fade show active mx-4" id="technical-data-tab" data-tab-label="Technical Data" role="tabpanel" aria-labelledby="technical-data-tab-tab"><div class="product_details_anchors"><div class="product-pages-anchors nav mx-0 pt-4 pb-2 m___nav-anchors d-none d-lg-flex"><li id="product-specifications_li" class="nav-item m-0"> <a class="nav-link py-0 px-2 jump-anchor active" href="#product-specifications" id="product-specifications_li" >Product Specifications</a> </li> <li id="linearity_li" class="nav-item m-0"> <a class="nav-link py-0 px-2 jump-anchor" href="#linearity" id="linearity_li" >Linearity</a> </li> <li id="scientific-data_li" class="nav-item m-0"> <a class="nav-link py-0 px-2 jump-anchor" href="#scientific-data" id="scientific-data_li" >Scientific Data</a> </li> <li id="preparation-and-storage_li" class="nav-item m-0"> <a class="nav-link py-0 px-2 jump-anchor" href="#preparation-and-storage" id="preparation-and-storage_li" >Preparation and Storage</a> </li> <li id="background_li" class="nav-item m-0"> <a class="nav-link py-0 px-2 jump-anchor" href="#background" id="background_li" >Background</a> </li> <li id="product-documents_li" class="nav-item m-0"> <a class="nav-link py-0 px-2 product-documents datasheet_static_link" href="#product-documents" id="product-documents_li" >Product Datasheets</a> </li> </div> <div id="product-specifications" class="nav-link px-0" data-anchor-label="Product Specifications"><div id="product_specifications_section"><h3>Product Specifications for Simple Plex Human Caspase-1 Cartridge (2nd Gen)</h3><table class="table-bordered table" id="table_wrapper"><tr class="product-data"> <td class="product-data-label font-weight-bold p-3 align-top text-md-right w-25">Assay Type</td> <td class="product-data-value p-3 px-4 text-break"> Automated sandwich ELISA </td> </tr> <tr class="product-data"> <td class="product-data-label font-weight-bold p-3 align-top text-md-right w-25">Format</td> <td class="product-data-value p-3 px-4 text-break"> Microfluidic cartridge containing three Glass Nano Reactors (GNR) </td> </tr> <tr class="product-data"> <td class="product-data-label font-weight-bold p-3 align-top text-md-right w-25">Reactivity</td> <td class="product-data-value p-3 px-4 text-break"> Human </td> </tr> </table> </div> </div> <div id="linearity" class="nav-link px-0" data-anchor-label="Linearity"><div id="linerarity_wrapper"><h3>Linearity</h3><div class="image-basic"> <img src="https://resources.bio-techne.com/images/products/spckb-ps-003613_simple-plex-cartridge-kit-for-16-samples-1-analyte-for-use-with-human-plasma-serum-11102021154323.jpg" alt="Human Caspase-1 Simple Plex Assay Linearity" title="Human Caspase-1 Simple Plex Assay Linearity" /> </div> </div> </div> <div id="scientific-data" class="nav-link px-0" data-anchor-label="Scientific Data"><table class="product-data-wrapper tablesaw tablesaw-stack table" id="data_image_table_wrapper"><h3>Scientific Data Examples for Simple Plex Human Caspase-1 Cartridge (2nd Gen)</h3><article class="product-data-wrapper"> <tr class="row m___product-data-examples"> <td class="border-0"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand=""> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/spckb-ps-003613_simple-plex-cartridge-kit-for-16-samples-1-analyte-for-use-with-human-plasma-serum-11102021154118.jpg" data-srcset="https://resources.bio-techne.com/images/products/spckb-ps-003613_simple-plex-cartridge-kit-for-16-samples-1-analyte-for-use-with-human-plasma-serum-11102021154118.jpg" alt="Human Caspase-1 Simple Plex Assay Standard Curve" title="Human Caspase-1 Simple Plex Assay Standard Curve" data-caption="" data-badges="" data-application="N/A" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </td> <td class="w-75 border-0 align-top"> <p> <strong>Human Caspase-1 Simple Plex Assay Standard Curve</strong> </p> </td> </tr> </article> </table> </div> <div id="preparation-and-storage" class="nav-link px-0" data-anchor-label="Preparation and Storage"><div id="elisa_preparation_storage"><h3>Preparation and Storage</h3><table class="table-bordered table" id="elisa_preparation_storage_table"><tr class="product-data"> <td class="product-data-label font-weight-bold p-3 align-top text-md-right w-25">Shipping</td> <td class="product-data-value p-3 px-4 text-break"> The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. </td> </tr> <tr class="product-data"> <td class="product-data-label font-weight-bold p-3 align-top text-md-right w-25">Stability & Storage</td> <td class="product-data-value p-3 px-4 text-break"> Store the unopened product at 2 - 8 °C. Do not use past expiration date. </td> </tr> </table> </div> </div> <div id="background" class="nav-link px-0" data-anchor-label="Background"><div id="background_information_wrapper"> <div id="background_information_wrapper"> <h3> Background: Caspase-1 </h3> <article class="product-data-wrapper"> <P>Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases). Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7).</P> <P> Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi. Cell-permeable and irreversible peptide inhibitors are also available for different caspases.</P> </article> <table class="tablesaw tablesaw-stack table-bordered" id="prep_storage_wrapper"> <thead style="display:none;"> <th>Item</th> <th>Value</th> </thead> <tbody> <tr class="product-data"> <td class="product-data-label font-weight-bold p-3 align-top text-md-right">Entrez Gene IDs</td> <td class="product-data-value w-75 p-3 px-4"> 834 (Human) </td> </tr> <tr class="product-data"> <td class="product-data-label font-weight-bold p-3 align-top text-md-right">Alternate Names</td> <td class="product-data-value w-75 p-3 px-4"> CASP-1, CASP1, CASP1 nirs variant 1, Caspase-1, Caspase-1 subunit p10, Caspase-1 subunit p20, Caspase1, EC 3.4.22.36, EC:3.4.22.36, ICE, IL-1 beta-converting enzyme, IL-1BC, IL1B-convertase, IL1BC, IL1BCE, Interleukin-1 beta convertase, Interleukin-1 beta-converting enzyme, caspase 1, apoptosis-related cysteine peptidase, interleukin 1, beta, convertase, interleukin 1-B converting enzyme, p45 </td> </tr> </tbody> </table> </div> </div> </div> <div id="product-datasheets-anchor" class="nav-link static-anchor p-0" data-anchor-label="Product Datasheets"></div> </div> </div> <div class="tab-pane fade mx-4 py-4" id="citations-tab" data-tab-label="Citations" role="tabpanel" aria-labelledby="citations-tab-tab"><div class="product_details_anchors mb-2"> <div class="nav mx-0 pt-4 pb-2 m___nav-anchors d-none d-lg-flex"> <li class="nav-item m-0"> <a class="nav-link jump-anchor active" href="#citations"> Citations </a> </li> </div> </div> <div id="citations"> <section id="citations-tab-content-placeholder" class="tab-content-placeholder" data-id="citations" data-product_code="SPCKB-PS-003613"> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"> <span class="sr-only">Loading...</span> </div> </section> </div> </div> </div> </div> <div id="compatible-instruments-wrapper"><div id="compatible-intruments-anchor"></div> <div id="compatible-instruments" class="top_region px-0"> <div class="rounded-top bg-white"> <h3 class="m-0 p-3">Compatible Instruments</h3> </div> <div id="carouselCompatiableInstrument" class="carousel slide" data-ride="carousel"> <div class="carousel-inner"> <div class="carousel-item active"> <div class="row w-75 m-auto"> <div class="col-md-4"> <img src="https://resources.rndsystems.com/images/datasheets/Ella_System_600100_ELISA_2642.png" alt="Ella Automated Immunoassay System" title="Ella Automated Immunoassay System" loading="lazy"/> </div> <div class="col-md-8"> <div class="carousel-caption position-initial"> <h4>Ella - Automated Immunoassay Platform | ProteinSimple </h4> <article>Ella from ProteinSimple, a Bio-Techne brand. Get single or multiplex immunoassay results in less than 90 minutes that are consistent and highly reproducible. </article> <div class="mt-3"> <a href="/p/simple-plex/ella-automated-immunoassay-system_600-100" class="btn btn-primary"> Learn More </a> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div id="product-documents"> <div id="datasheet-accordion" class="accordion border mb-4"> <div class="rounded-top bg-white"> <h3 class="m-0 p-3">Product Documents for Simple Plex Human Caspase-1 Cartridge (2nd Gen)</h3> </div> <div class="vtab-section" data-section="Product Datasheets"> <div class="card-header rounded-top"> <a class="" data-toggle="collapse" data-target="#collapse_two" aria-expanded="true" aria-controls="collapse_two" id="product-datasheets-link"> <h5 class="mb-0"> Product Datasheets </h5> </a> </div> <div id="collapse_two" class="collapse show prod_datasheet_link" aria-labelledby="heading_two" data-parent="#datasheet-accordion"> <div class="card-body"> <div class="row"> <div class="col-md-12"> <a href="/" class="arena_link download_arena_document" data-category_id="24" data-document_id="d10-1220-001" data-document_type="product-insert" target="_blank" rel="nofollow">Download Product Insert</a> </div> <div class="col-md-6 datasheet-pdf-result"> </div> </div> </div> </div> </div> <div class="card-header"> <a data-toggle="collapse" data-target="#collapse_one" aria-expanded="false" class="collapsed" aria-controls="collapse_one"> <h5 class="mb-0"> COA </h5> </a> </div> <div id="collapse_one" class="collapse " aria-labelledby="heading_one" data-parent="#datasheet-accordion"> <div class="card-body"> <form novalidate="novalidate" data-drupal-selector="protein-simple-coa-form" action="#protein-simple-coa-form" method="post" id="protein-simple-coa-form" accept-charset="UTF-8"> <div class="row"> <div class="col-12"> <h2>Certificate of Analysis</h2> <p>To download a Certificate of Analysis, please enter a lot number in the search box below.</p> </div> </div> <section class="row"> <div class="col-md-6"> <form novalidate="novalidate" data-drupal-selector="protein-simple-coa-form"> <div class="form-row align-items-center"> <div class="col-md-10 my-1"> <input data-drupal-selector="form-69zhkcm5ca0t1z97x5yveclkn0fvrqttgfds7btxsns" type="hidden" name="form_build_id" value="form-69zHkcM5cA0T1Z97X5YVeclkN0fvRqttgfdS7BtxSns" /> <input data-drupal-selector="edit-protein-simple-coa-form" type="hidden" name="form_id" value="protein_simple_coa_form" /> <input id="ps-part-number" data-drupal-selector="edit-product-code" type="hidden" name="product_code" value="SPCKB-PS-003613" /> <div class="js-form-item form-item pb-3 js-form-type-textfield form-item-lot-number js-form-item-lot-number form-no-label"> <input autocomplete="off" class="form-control cofa-lookup form-text" id="ps-lot-number" placeholder="Lot Number" data-drupal-selector="edit-lot-number" type="text" name="lot_number" value="" size="60" maxlength="128" /> </div> <input 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