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url('/uploads/b/116812555-725646270591702307/adobestock_603094107_492.jpg');" data-background-color="#fbfcfc" data-background-image="none" data-video_type="upload" data-video_url="/uploads/b/116812555-725646270591702307/adobestock_603094107_492.mp4" data-video_id="/uploads/b/116812555-725646270591702307/adobestock_603094107_492.mp4" data-loop="1" data-autoplay="1" data-mute="1" data-background_url="/uploads/b/116812555-725646270591702307/adobestock_603094107_492.jpg" > <div class="wsite-section-content"> <div class="container"> <div class="wsite-section-elements"> <div class="paragraph" style="text-align:left;"><font size="6" color="#ffffff"><strong>INNOVATING RECEPTOR-INDEPENDENT DRUG DELIVERY TECHNOLOGY FOR THE MOST AGGRESSIVE DISEASES</strong></font></div> </div> </div> </div> </div> </div> <div class="wsite-section-wrap"> <div class="wsite-section wsite-body-section wsite-section-bg-gradient wsite-background-9" style="vertical-align: top;height: 128px;background: #02131A;background: linear-gradient(180deg, #02131A 0%, #0B2736 70%);" > <div class="wsite-section-content"> <div class="container"> <div class="wsite-section-elements"> <div class="paragraph" style="text-align:center;"><font color="#ffffff"><font size="5" style="">At the center of our approach is a cellular process that enables our delivery technology </font><font size="5" style="">to be both disease and payload agnostic.</font></font></div> </div> </div> </div> </div> </div> <div class="wsite-section-wrap"> <div class="wsite-section wsite-body-section wsite-background-10" style="height: auto;" > <div class="wsite-section-content"> <div class="container"> <div class="wsite-section-elements"> <div class="paragraph"><font size="6">KEY PROPERTIES</font></div> <div><div class="wsite-multicol"><div class="wsite-multicol-table-wrap" style="margin:0 -15px;"> <table class="wsite-multicol-table"> <tbody class="wsite-multicol-tbody"> <tr class="wsite-multicol-tr"> <td class="wsite-multicol-col" style="width:33.333333333333%; padding:0 15px;"> <div><div class="wsite-image wsite-image-border-none " style="padding-top:10px;padding-bottom:10px;margin-left:0px;margin-right:0px;text-align:center"> <a> <img src="/uploads/1/1/6/8/116812555/published/picture8.png?1712584557" alt="Picture" style="width:58;max-width:100%" /> </a> <div style="display:block;font-size:90%"></div> </div></div> <div class="paragraph" style="text-align:center;"><font size="4"><strong>SCALABLE</strong><br /></font><font size="3">Approach allows expansion into various indications (oncology, neurodegenerative, inflammatory, and infectious diseases)</font></div> </td> <td class="wsite-multicol-col" style="width:33.333333333333%; padding:0 15px;"> <div><div class="wsite-image wsite-image-border-none " style="padding-top:10px;padding-bottom:10px;margin-left:0;margin-right:0;text-align:center"> <a> <img src="/uploads/1/1/6/8/116812555/published/picture6.png?1712584393" alt="Picture" style="width:auto;max-width:100%" /> </a> <div style="display:block;font-size:90%"></div> </div></div> <div class="paragraph" style="text-align:center;"><strong><font size="4">À LA CARTE PAYLOAD SELECTION</font></strong><br /><strong><font size="4"></font></strong><font size="3">Amenable to various types of cargo (small molecules, PROTACs, radioisotopes, siRNA)</font></div> </td> <td class="wsite-multicol-col" style="width:33.333333333333%; padding:0 15px;"> <div><div class="wsite-image wsite-image-border-none " style="padding-top:10px;padding-bottom:10px;margin-left:0;margin-right:0;text-align:center"> <a> <img src="/uploads/1/1/6/8/116812555/published/picture10.png?1712584409" alt="Picture" style="width:40;max-width:100%" /> </a> <div style="display:block;font-size:90%"></div> </div></div> <div class="paragraph" style="text-align:center;"><font size="4"><strong>SITE-SPECIFIC CONJUGATION</strong></font><br /><font size="3">Precise control over Drug-to-Protein ratio</font></div> </td> </tr> </tbody> </table> </div></div></div> <div><div class="wsite-multicol"><div class="wsite-multicol-table-wrap" style="margin:0 -15px;"> <table class="wsite-multicol-table"> <tbody class="wsite-multicol-tbody"> <tr class="wsite-multicol-tr"> <td class="wsite-multicol-col" style="width:33.333333333333%; padding:0 15px;"> <div><div class="wsite-image wsite-image-border-none " style="padding-top:10px;padding-bottom:10px;margin-left:0;margin-right:0;text-align:center"> <a> <img src="/uploads/1/1/6/8/116812555/editor/picture9.png?1712584422" alt="Picture" style="width:54;max-width:100%" /> </a> <div style="display:block;font-size:90%"></div> </div></div> <div class="paragraph" style="text-align:center;"><font size="4"><strong>DISEASE-SPECIFIC BIODISTRIBUTION</strong><br /></font><font size="3">Mid-range molecular weight (10kDa) protein, delivering rapid tissue penetration and tunable PK</font></div> </td> <td class="wsite-multicol-col" style="width:33.333333333333%; padding:0 15px;"> <div><div class="wsite-image wsite-image-border-none " style="padding-top:10px;padding-bottom:10px;margin-left:0px;margin-right:0px;text-align:center"> <a> <img src="/uploads/1/1/6/8/116812555/published/picture11.png?1712584430" alt="Picture" style="width:72;max-width:100%" /> </a> <div style="display:block;font-size:90%"></div> </div></div> <div class="paragraph" style="text-align:center;"><font size="4"><strong style="">REDUCED TOXICITY</strong><br /></font><font size="3">Renal elimination with potential to reduce toxicity events in liver and gut</font></div> </td> <td class="wsite-multicol-col" style="width:33.333333333333%; padding:0 15px;"> <div><div class="wsite-image wsite-image-border-none " style="padding-top:10px;padding-bottom:10px;margin-left:0;margin-right:0;text-align:center"> <a> <img src="/uploads/1/1/6/8/116812555/published/picture7.png?1712584435" alt="Picture" style="width:55;max-width:100%" /> </a> <div style="display:block;font-size:90%"></div> </div></div> <div class="paragraph" style="text-align:center;"><font size="4"><strong>DE-RISKED MANUFACTURING</strong><br /></font><font size="3">Scalable manufacturing using established methodologies</font></div> </td> </tr> </tbody> </table> </div></div></div> </div> </div> </div> </div> </div> <div class="wsite-section-wrap"> <div class="wsite-section wsite-body-section wsite-section-bg-color wsite-background-11" style="background-color: #0B2736;background-image: none;" > <div class="wsite-section-content"> <div class="container"> <div class="wsite-section-elements"> <div><div class="wsite-multicol"><div class="wsite-multicol-table-wrap" style="margin:0 -15px;"> <table class="wsite-multicol-table"> <tbody class="wsite-multicol-tbody"> <tr class="wsite-multicol-tr"> <td class="wsite-multicol-col" style="width:61.739130434783%; padding:0 15px;"> <div class="paragraph"><font size="6" color="#fefefe">EVOLVING THE TREATMENT PARADIGM FOR RAS-ACTIVATED CANCERS</font></div> </td> <td 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</tr> </tbody> </table> </div></div></div> <div class="paragraph"><font color="#ffffff">Combining well-defined disease biology with clinically-validated payloads, our delivery platform holds much promise for the field of cancer therapeutics. It offers a clear pathway to create safe and effective therapeutics for the most recalcitrant cancers. </font></div> </div> </div> </div> </div> </div> <div class="wsite-section-wrap"> <div class="wsite-section wsite-body-section wsite-section-bg-color wsite-background-12" style="background-color: #e4e4e4;background-image: none;" > <div class="wsite-section-content"> <div class="container"> <div class="wsite-section-elements"> <div class="paragraph"><font size="6">RAS CANCERS AT A GLANCE</font></div> <div class="paragraph"><font size="3">● RAS mutations drive 1 in 5 cancer diagnoses in the United States, but there are limited treatment options for these tumors</font><br /><font size="3">● RAS-activated cancer growth is largely fueled by macropinocytosis, a cellular process that facilitates the bulk internalization of extracellular material</font><br /><font size="3">● Our novel drug approach exploits macropinocytosis to deliver a toxic payload to cancer cells, while avoiding healthy cells</font></div> </div> </div> </div> </div> </div> <div class="wsite-section-wrap"> <div class="wsite-section wsite-body-section wsite-background-13" > <div class="wsite-section-content"> <div class="container"> <div class="wsite-section-elements"> <div class="paragraph"><font size="6">A BETTER WAY FORWARD</font></div> <div><div class="wsite-multicol"><div class="wsite-multicol-table-wrap" style="margin:0 -15px;"> <table class="wsite-multicol-table"> <tbody class="wsite-multicol-tbody"> <tr class="wsite-multicol-tr"> <td class="wsite-multicol-col" style="width:50%; padding:0 15px;"> <div class="paragraph"><span>Tezcat has developed a novel protein-drug conjugate that exploits the macropinocytosis process to deliver a toxic payload to cancer cells. Tezcat’s breakthrough therapy combines a carrier protein with a toxic payload, which is internalized by the cancer cells during macropinocytosis.<br /></span></div> <div><div class="wsite-image wsite-image-border-none " style="padding-top:10px;padding-bottom:10px;margin-left:0;margin-right:0;text-align:center"> <a> <img src="/uploads/1/1/6/8/116812555/published/picture12.png?1711736055" alt="Picture" style="width:355;max-width:100%" /> </a> <div style="display:block;font-size:90%"></div> </div></div> <div class="paragraph"><span>Cancer cells experiencing high levels of macropinocytosis “eat” the toxic payload and are destroyed in the process. At the same time, healthy cells do not exhibit macropinocytosis, so the toxic payload is not “eaten” by these cells, and they are not harmed in the process.</span></div> </td> <td class="wsite-multicol-col" style="width:50%; padding:0 15px;"> <div class="wsite-spacer" style="height:50px;"></div> <div><div class="wsite-image wsite-image-border-none " style="padding-top:10px;padding-bottom:10px;margin-left:0px;margin-right:0px;text-align:center"> <a> <img src="/uploads/1/1/6/8/116812555/published/picture13.png?1711736073" alt="Picture" style="width:545;max-width:100%" /> </a> <div style="display:block;font-size:90%"></div> </div></div> </td> </tr> </tbody> </table> </div></div></div> </div> </div> </div> </div> </div> <div class="wsite-section-wrap"> <div class="wsite-section wsite-body-section wsite-background-14" > <div class="wsite-section-content"> <div class="container"> <div class="wsite-section-elements"> <div class="paragraph"><font size="6">PIPELINE</font></div> <div class="paragraph">Our approach facilitates a la carte selection of drug payloads to match disease-specific biology. Our internal pipeline reflects multiple programs that will begin to unlock the full potential of our delivery platform.<br /></div> <div><div class="wsite-image wsite-image-border-none " style="padding-top:10px;padding-bottom:10px;margin-left:0;margin-right:0;text-align:center"> <a> <img src="/uploads/1/1/6/8/116812555/published/picture14.png?1711736670" alt="Picture" style="width:837;max-width:100%" /> </a> <div style="display:block;font-size:90%"></div> </div></div> </div> </div> </div> </div> </div> <div class="wsite-section-wrap"> <div class="wsite-section wsite-body-section wsite-section-bg-color wsite-background-15" style="background-color: #e4e4e4;background-image: none;" > <div class="wsite-section-content"> <div class="container"> <div class="wsite-section-elements"> <div class="paragraph"><font size="6">PARTNERING INQUIRIES</font></div> <div class="paragraph">Beyond oncology, we recognize the vast potential of our technology and one of our goals is to develop innovative new therapeutics that exploit our drug delivery technology through creative academic and industry collaborations. If you are interested in exploring opportunities, please contact us below.</div> </div> </div> </div> </div> </div> <div class="wsite-section-wrap"> <div class="wsite-section wsite-body-section wsite-section-bg-color wsite-background-16" style="background-color: #ffffff;background-image: none;" > <div class="wsite-section-content"> <div class="container"> <div class="wsite-section-elements"> <div class="paragraph"><font size="6">CONTACT US</font></div> <div><div class="wsite-multicol"><div class="wsite-multicol-table-wrap" style="margin:0 -15px;"> <table class="wsite-multicol-table"> <tbody class="wsite-multicol-tbody"> <tr class="wsite-multicol-tr"> <td class="wsite-multicol-col" style="width:50%; padding:0 15px;"> <div> <form enctype="multipart/form-data" action="//www.weebly.com/weebly/apps/formSubmit.php" method="POST" id="form-441198032461180296"> <div id="441198032461180296-form-parent" class="wsite-form-container" style="margin-top:10px;"> <ul class="formlist" id="441198032461180296-form-list"> <label class="wsite-form-label wsite-form-fields-required-label"><span class="form-required">*</span> Indicates required field</label><div><div class="wsite-form-field wsite-name-field" style="margin:5px 0px 5px 0px;"> <label class="wsite-form-label">Name <span class="form-required">*</span></label> <div style="clear:both;"></div> <div class="wsite-form-input-container wsite-form-left wsite-form-input-first-name"> <input aria-required="true" id="input-104086924537988231" class="wsite-form-input wsite-input" placeholder="First" type="text" name="_u104086924537988231[first]" /> <label class="wsite-form-sublabel" for="input-104086924537988231">First</label> </div> <div class="wsite-form-input-container wsite-form-right wsite-form-input-last-name"> <input aria-required="true" id="input-104086924537988231-1" class="wsite-form-input wsite-input" placeholder="Last" type="text" name="_u104086924537988231[last]" /> <label class="wsite-form-sublabel" for="input-104086924537988231-1">Last</label> </div> <div id="instructions-104086924537988231" class="wsite-form-instructions" style="display:none;"></div> </div> <div style="clear:both;"></div></div> <div><div class="wsite-form-field" style="margin:5px 0px 5px 0px;"> <label class="wsite-form-label" for="input-845962681767728782">Email <span class="form-required">*</span></label> <div class="wsite-form-input-container"> <input aria-required="true" id="input-845962681767728782" class="wsite-form-input wsite-input wsite-input-width-370px" type="text" name="_u845962681767728782" /> </div> <div id="instructions-845962681767728782" class="wsite-form-instructions" style="display:none;"></div> </div></div> <div><div class="wsite-multicol"><div class="wsite-multicol-table-wrap" style="margin:0 -0px;"> <table class="wsite-multicol-table"> <tbody class="wsite-multicol-tbody"> <tr class="wsite-multicol-tr"> <td class="wsite-multicol-col" style="width:89.209726443769%; 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