X-Ray Fluorescence Molecular Imaging with Improved Sensitivity for Biomedical Applications

<!DOCTYPE html> <html lang="en" dir="ltr"> <head>  <script async src="https://www.googletagmanager.com/gtag/js?id=G-P63WKM1TM1"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-P63WKM1TM1'); </script>  <script type="text/javascript" > (function(m,e,t,r,i,k,a){m[i]=m[i]||function(){(m[i].a=m[i].a||[]).push(arguments)}; m[i].l=1*new Date(); for (var j = 0; j < document.scripts.length; j++) {if (document.scripts[j].src === r) { return; }} k=e.createElement(t),a=e.getElementsByTagName(t)[0],k.async=1,k.src=r,a.parentNode.insertBefore(k,a)}) (window, document, "script", "https://mc.yandex.ru/metrika/tag.js", "ym"); ym(55165297, "init", { clickmap:false, trackLinks:true, accurateTrackBounce:true, webvisor:false }); </script> <noscript><div><img src="https://mc.yandex.ru/watch/55165297" style="position:absolute; left:-9999px;" alt="" /></div></noscript>    <title>X-Ray Fluorescence Molecular Imaging with Improved Sensitivity for Biomedical Applications</title> <meta name="description" content="X-Ray Fluorescence Molecular Imaging with Improved Sensitivity for Biomedical Applications"> <meta name="keywords" content="Molecular imaging, X-ray fluorescence, chemical sensitivity, X-ray scattering. "> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <meta name="citation_title" content="X-Ray Fluorescence Molecular Imaging with Improved Sensitivity for Biomedical Applications"> <meta name="citation_author" content="Guohua Cao"> <meta name="citation_author" content="Xu Dong"> <meta name="citation_publication_date" content="2018/06/01"> <meta name="citation_journal_title" content="International Journal of Biomedical and Biological Engineering"> <meta name="citation_volume" content="12"> <meta name="citation_issue" content="6"> <meta name="citation_firstpage" content="288"> <meta name="citation_lastpage" content="291"> <meta name="citation_pdf_url" content="https://publications.waset.org/10009278/pdf"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" type="button" data-toggle="collapse" data-target="#navbarMenu" aria-controls="navbarMenu" aria-expanded="false" aria-label="Toggle navigation"> <span class="navbar-toggler-icon"></span> </button> <div class="w-100"> <div class="d-none d-lg-flex flex-row-reverse"> <form method="get" action="https://waset.org/search" class="form-inline my-2 my-lg-0"> <input class="form-control mr-sm-2" type="search" placeholder="Search Conferences" value="" name="q" aria-label="Search"> <button class="btn btn-light my-2 my-sm-0" type="submit"><i class="fas fa-search"></i></button> </form> </div> <div class="collapse navbar-collapse mt-1" id="navbarMenu"> <ul class="navbar-nav ml-auto align-items-center" id="mainNavMenu"> <li class="nav-item"> <a class="nav-link" href="https://waset.org/conferences" title="Conferences in 2024/2025/2026">Conferences</a> </li> <li class="nav-item"> <a class="nav-link" href="https://waset.org/disciplines" title="Disciplines">Disciplines</a> </li> <li class="nav-item"> <a class="nav-link" href="https://waset.org/committees" rel="nofollow">Committees</a> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdownPublications" role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"> Publications </a> <div class="dropdown-menu" aria-labelledby="navbarDropdownPublications"> <a class="dropdown-item" href="https://publications.waset.org/abstracts">Abstracts</a> <a class="dropdown-item" href="https://publications.waset.org">Periodicals</a> <a class="dropdown-item" href="https://publications.waset.org/archive">Archive</a> </div> </li> <li class="nav-item"> <a class="nav-link" href="https://waset.org/page/support" title="Support">Support</a> </li> </ul> </div> </div> </nav> </div> </header> <main> <div class="container mt-4"> <div class="row"> <div class="col-md-9 mx-auto"> <form method="get" action="https://publications.waset.org/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value=""> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 33093</div> </div> </div> </div> <div class="card publication-listing mt-3 mb-3"> <h5 class="card-header" style="font-size:.9rem">X-Ray Fluorescence Molecular Imaging with Improved Sensitivity for Biomedical Applications</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Guohua%20Cao">Guohua Cao</a>, <a href="https://publications.waset.org/search?q=Xu%20Dong"> Xu Dong</a> </p> <p class="card-text"><strong>Abstract:</strong></p> X-ray Fluorescence Molecular Imaging (XFMI) holds great promise as a low-cost molecular imaging modality for biomedical applications with high chemical sensitivity. However, for in vivo biomedical applications, a key technical bottleneck is the relatively low chemical sensitivity of XFMI, especially at a reasonably low radiation dose. In laboratory x-ray source based XFMI, one of the main factors that limits the chemical sensitivity of XFMI is the scattered x-rays. We will present our latest findings on improving the chemical sensitivity of XFMI using excitation beam spectrum optimization. XFMI imaging experiments on two mouse-sized phantoms were conducted at three different excitation beam spectra. Our results show that the minimum detectable concentration (MDC) of iodine can be readily increased by five times via excitation spectrum optimization. Findings from this investigation could find use for in vivo pre-clinical small-animal XFMI in the future. <iframe src="https://publications.waset.org/10009278.pdf" style="width:100%; height:400px;" frameborder="0"></iframe> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Molecular%20imaging" title="Molecular imaging">Molecular imaging</a>, <a href="https://publications.waset.org/search?q=X-ray%20fluorescence" title=" X-ray fluorescence"> X-ray fluorescence</a>, <a href="https://publications.waset.org/search?q=chemical%20sensitivity" title=" chemical sensitivity"> chemical sensitivity</a>, <a href="https://publications.waset.org/search?q=X-ray%20scattering." title=" X-ray scattering. "> X-ray scattering. </a> </p> <p class="card-text"><strong>Digital Object Identifier (DOI):</strong> <a href="https://doi.org/10.5281/zenodo.1317414" target="_blank">doi.org/10.5281/zenodo.1317414</a> </p> <a href="https://publications.waset.org/10009278/x-ray-fluorescence-molecular-imaging-with-improved-sensitivity-for-biomedical-applications" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/10009278/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/10009278/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/10009278/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/10009278/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/10009278/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/10009278/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/10009278/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/10009278/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/10009278/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/10009278/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/10009278.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">943</span> </span> <p class="card-text"><strong>References:</strong></p> <br>[1] Jones, B. L., et al., Experimental demonstration of benchtop x-ray fluorescence computed tomography (xfct) of gold nanoparticle-loaded objects using lead- and tin-filtered polychromatic cone-beams. Phys Med Biol, 2012. 57(23): p. N457-67. <br>[2] Kuang, Y., et al., First demonstration of multiplexed x-ray fluorescence computed tomography (xfct) imaging. IEEE transactions on medical imaging, 2013. 32(2): p. 262-267. <br>[3] Ren, L., et al., Three-dimensional x-ray fluorescence mapping of a gold nanoparticle-loaded phantom. Med Phys, 2014. 41(3): p. 031902. <br>[4] Yoon, C., Y. Kim, and W. Lee, 3d non-destructive fluorescent x-ray computed tomography with a cdte array. IEEE Transactions on Nuclear Science, 2016. 63(3): p. 1844-1853. <br>[5] Bazalova, M., et al., L-shell x-ray fluorescence computed tomography (xfct) imaging of cisplatin. Phys. Med. Biol, 2014. 59(1): p. 219-232. <br>[6] Bazalova-Carter, M., et al., Experimental validation of l-shell x-ray fluorescence computed tomography imaging: Phantom study. Journal of Medical Imaging, 2015. 2(4): p. 043501-043501. <br>[7] Manohar, N., F.J. Reynoso, and S.H. Cho, Experimental demonstration of direct l鈥恠hell x鈥恟ay fluorescence imaging of gold nanoparticles using a benchtop x鈥恟ay source. Medical physics, 2013. 40(8). <br>[8] Cong, W., H. Shen, and G. Wang, Spectrally resolving and scattering-compensated x-ray luminescence/fluorescence computed tomography. Journal of biomedical optics, 2011. 16(6): p. 066014-066014-7. <br>[9] Ricketts, K., et al., A quantitative x-ray detection system for gold nanoparticle tumour biomarkers. Phys Med Biol, 2012. 57(17): p. 5543-55. <br>[10] Ahmad, M., et al., Order of magnitude sensitivity increase in x-ray fluorescence computed tomography (xfct) imaging with an optimized spectro-spatial detector configuration: Theory and simulation. IEEE Trans Med Imaging, 2014. 33(5): p. 1119-28. <br>[11] Ahmad, M., et al., Optimized detector angular configuration increases the sensitivity of x-ray fluorescence computed tomography (xfct). IEEE Trans Med Imaging, 2015. 34(5): p. 1140-7. <br>[12] Wu, D., et al. Measurements of gold nanoparticle concentration with k-shell x-ray fluorescence spectrum. in Proc. of SPIE Vol. 2017. <br>[13] Cao, G., J. Lu, and O. Zhou. X-ray fluorescence molecular imaging with high sensitivity: Feasibility study in phantoms. in SPIE Medical Imaging. 2012. International Society for Optics and Photonics. <br>[14] Takeda, T., et al., Iodine imaging in thyroid by fluorescent x-ray ct with 0.05 mm spatial resolution. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2001. 467: p. 1318-1321. <br>[15] Wu, D., et al., A method of measuring gold nanoparticle concentrations by x鈥恟ay fluorescence for biomedical applications. Medical physics, 2013. 40(5). <br>[16] Larsson, J. C., et al. High-spatial-resolution nanoparticle x-ray fluorescence tomography. in Medical Imaging 2016: Physics of Medical Imaging. 2016. International Society for Optics and Photonics. <br>[17] Shilo, M., et al., Nanoparticles as computed tomography contrast agents: Current status and future perspectives. Nanomedicine, 2012. 7(2): p. 257-269. <br>[18] Ricketts, K., et al., A bench-top k x-ray fluorescence system for quantitative measurement of gold nanoparticles for biological sample diagnostics. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2016. 816: p. 25-32. <br>[19] Takeda, T., et al. Fluorescent x-ray computed tomography with synchrotron radiation using fan collimator. in Proc. 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X-Ray Fluorescence Molecular Imaging with Improved Sensitivity for Biomedical Applications