Search results for: PfPKG

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PfPKG</title> <meta name="description" content="Search results for: PfPKG"> <meta name="keywords" content="PfPKG"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" 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class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="PfPKG"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 1</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: PfPKG</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Combating Malaria: A Drug Discovery Approach Using Thiazole Derivatives Against Prolific Parasite Enzyme PfPKG</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hari%20Bezwada">Hari Bezwada</a>, <a href="https://publications.waset.org/abstracts/search?q=Michelle%20Cheon"> Michelle Cheon</a>, <a href="https://publications.waset.org/abstracts/search?q=Ryan%20Divan"> Ryan Divan</a>, <a href="https://publications.waset.org/abstracts/search?q=Hannah%20Escritor"> Hannah Escritor</a>, <a href="https://publications.waset.org/abstracts/search?q=Michelle%20Kagramian"> Michelle Kagramian</a>, <a href="https://publications.waset.org/abstracts/search?q=Isha%20Korgaonkar"> Isha Korgaonkar</a>, <a href="https://publications.waset.org/abstracts/search?q=Maya%20MacAdams"> Maya MacAdams</a>, <a href="https://publications.waset.org/abstracts/search?q=Udgita%20Pamidigantam"> Udgita Pamidigantam</a>, <a href="https://publications.waset.org/abstracts/search?q=Richard%20Pilny"> Richard Pilny</a>, <a href="https://publications.waset.org/abstracts/search?q=Eleanor%20Race"> Eleanor Race</a>, <a href="https://publications.waset.org/abstracts/search?q=Angadh%20Singh"> Angadh Singh</a>, <a href="https://publications.waset.org/abstracts/search?q=Nathan%20Zhang"> Nathan Zhang</a>, <a href="https://publications.waset.org/abstracts/search?q=LeeAnn%20Nguyen"> LeeAnn Nguyen</a>, <a href="https://publications.waset.org/abstracts/search?q=Fina%20Liotta"> Fina Liotta</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Malaria is a deadly disease caused by the Plasmodium parasite, which continues to develop resistance to current antimalarial drugs. In this research project, the effectiveness of numerous thiazole derivatives was explored in inhibiting the PfPKG, a crucial part of the Plasmodium life cycle. This study involved the synthesis of six thiazole-derived amides to inhibit the PfPKG pathway. Nuclear Magnetic Resonance (NMR) spectroscopy and Infrared (IR) spectroscopy were used to characterize these compounds. Furthermore, AutoDocking software was used to predict binding affinities of these thiazole-derived amides in silico. In silico, compound 6 exhibited the highest predicted binding affinity to PfPKG, while compound 5 had the lowest affinity. Compounds 1-4 displayed varying degrees of predicted binding affinity. In-vitro, it was found that compound 4 had the best percent inhibition, while compound 5 had the worst percent inhibition. Overall, all six compounds had weak inhibition (approximately 30-39% at 10 渭M), but these results provide a foundation for future drug discovery experiments. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Medicinal%20Chemistry" title="Medicinal Chemistry">Medicinal Chemistry</a>, <a href="https://publications.waset.org/abstracts/search?q=Malaria" title=" Malaria"> Malaria</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20discovery" title=" drug discovery"> drug discovery</a>, <a href="https://publications.waset.org/abstracts/search?q=PfPKG" title=" PfPKG"> PfPKG</a>, <a href="https://publications.waset.org/abstracts/search?q=Thiazole" title=" Thiazole"> Thiazole</a>, <a href="https://publications.waset.org/abstracts/search?q=Plasmodium" title=" Plasmodium"> Plasmodium</a> </p> <a href="https://publications.waset.org/abstracts/174021/combating-malaria-a-drug-discovery-approach-using-thiazole-derivatives-against-prolific-parasite-enzyme-pfpkg" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/174021.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">98</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational 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Search results for: PfPKG