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and hydrophobic polymers</title> <meta name="description" content="Search results for: hydrophilic and hydrophobic polymers"> <meta name="keywords" content="hydrophilic and hydrophobic polymers"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research 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method="get" action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="hydrophilic and hydrophobic polymers"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 1045</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: hydrophilic and hydrophobic polymers</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1045</span> Boiling Heat Transfer Enhancement Using Hydrophilic Millimeter Copper Free Particles</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Abbasali%20Abouei%20Mehrizi">Abbasali Abouei Mehrizi</a>, <a href="https://publications.waset.org/abstracts/search?q=Hao%20Wang"> Hao Wang</a>, <a href="https://publications.waset.org/abstracts/search?q=Leping%20Zhou"> Leping Zhou</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Modification of surface wettability is one of the conventional approaches to manipulate the boiling heat transfer. Instead of direct surface modification, in the present study, the surface is decorated with free copper particles with different hydrophobicity. We used millimeter-sized copper particles with two different hydrophobicity. The surface is covered with untreated, hydrophilic, and a combination of hydrophobic and hydrophilic copper particles separately, and the heat flux and wall superheat temperature was measured experimentally and compared with the bare polished copper surface. The results show that the untreated copper particles can slightly improve the boiling heat transfer when the hydrophilic copper particles have better performance. Combining hydrophilic and hydrophobic copper particles reduces boiling heat transfer. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=boiling%20heat%20transfer" title="boiling heat transfer">boiling heat transfer</a>, <a href="https://publications.waset.org/abstracts/search?q=copper%20balls" title=" copper balls"> copper balls</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrophobic" title=" hydrophobic"> hydrophobic</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrophilic" title=" hydrophilic"> hydrophilic</a> </p> <a href="https://publications.waset.org/abstracts/163360/boiling-heat-transfer-enhancement-using-hydrophilic-millimeter-copper-free-particles" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/163360.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">71</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1044</span> Micelles Made of Pseudo-Proteins for Solubilization of Hydrophobic Biologicals</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sophio%20Kobauri">Sophio Kobauri</a>, <a href="https://publications.waset.org/abstracts/search?q=David%20Tugushi"> David Tugushi</a>, <a href="https://publications.waset.org/abstracts/search?q=Vladimir%20P.%20Torchilin"> Vladimir P. Torchilin</a>, <a href="https://publications.waset.org/abstracts/search?q=Ramaz%20Katsarava"> Ramaz Katsarava</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Hydrophobic / hydrophilically modified functional polymers are of high interest in modern biomedicine due to their ability to solubilize water-insoluble / poorly soluble (hydrophobic) drugs. Among the many approaches that are being developed in this direction, one of the most effective methods is the use of polymeric micelles (PMs) (micelles formed by amphiphilic block-copolymers) for solubilization of hydrophobic biologicals. For therapeutic purposes, PMs are required to be stable and biodegradable, although quite a few amphiphilic block-copolymers are described capable of forming stable micelles with good solubilization properties. For obtaining micelle-forming block-copolymers, polyethylene glycol (PEG) derivatives are desirable to use as hydrophilic shell because it represents the most popular biocompatible hydrophilic block and various hydrophobic blocks (polymers) can be attached to it. Although the construction of the hydrophobic core, due to the complex requirements and micelles structure development, is the very actual and the main problem for nanobioengineers. Considering the above, our research goal was obtaining biodegradable micelles for the solubilization of hydrophobic drugs and biologicals. For this purpose, we used biodegradable polymers– pseudo-proteins (PPs)(synthesized with naturally occurring amino acids and other non-toxic building blocks, such as fatty diols and dicarboxylic acids) as hydrophobic core since these polymers showed reasonable biodegradation rates and excellent biocompatibility. In the present study, we used the hydrophobic amino acid – L-phenylalanine (MW 4000-8000Da) instead of L-leucine. Amino-PEG (MW 2000Da) was used as hydrophilic fragments for constructing the suitable micelles. The molecular weight of PP (the hydrophobic core of micelle) was regulated by variation of used monomers ratios. Micelles were obtained by dissolving of synthesized amphiphilic polymer in water. The micelle-forming property was tested using dynamic light scattering (Malvern zetasizer NanoZSZEN3600). The study showed that obtaining amphiphilic block-copolymer form stable neutral micelles 100 ± 7 nm in size at 10mg/mL concentration, which is considered as an optimal range for pharmaceutical micelles. The obtained preliminary data allow us to conclude that the obtained micelles are suitable for the delivery of poorly water-soluble drugs and biologicals. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=amino%20acid%20%E2%80%93%20L-phenylalanine" title="amino acid – L-phenylalanine">amino acid – L-phenylalanine</a>, <a href="https://publications.waset.org/abstracts/search?q=pseudo-proteins" title=" pseudo-proteins"> pseudo-proteins</a>, <a href="https://publications.waset.org/abstracts/search?q=amphiphilic%20block-copolymers" title=" amphiphilic block-copolymers"> amphiphilic block-copolymers</a>, <a href="https://publications.waset.org/abstracts/search?q=biodegradable%20micelles" title=" biodegradable micelles"> biodegradable micelles</a> </p> <a href="https://publications.waset.org/abstracts/109290/micelles-made-of-pseudo-proteins-for-solubilization-of-hydrophobic-biologicals" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/109290.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">134</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1043</span> Formulation and Evaluation of TDDS for Sustained Release Ondansetron HCL Patches</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Baljinder%20Singh">Baljinder Singh</a>, <a href="https://publications.waset.org/abstracts/search?q=Navneet%20Sharma"> Navneet Sharma</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The skin can be used as the site for drug administration for continuous transdermal drug infusion into the systemic circulation. For the continuous diffusion/penetration of the drugs through the intact skin surface membrane-moderated systems, matrix dispersion type systems, adhesive diffusion controlled systems and micro reservoir systems have been developed. Various penetration enhancers are used for the drug diffusion through skin. In matrix dispersion type systems, the drug is dispersed in the solvent along with the polymers and solvent allowed to evaporate forming a homogeneous drug-polymer matrix. Matrix type systems were developed in the present study. In the present work, an attempt has been made to develop a matrix-type transdermal therapeutic system comprising of ondansetron-HCl with different ratios of hydrophilic and hydrophobic polymeric combinations using solvent evaporation technique. The physicochemical compatibility of the drug and the polymers was studied by infrared spectroscopy. The results obtained showed no physical-chemical incompatibility between the drug and the polymers. The patches were further subjected to various physical evaluations along with the in-vitro permeation studies using rat skin. On the basis of results obtained form the in vitro study and physical evaluation, the patches containing hydrophilic polymers i.e. polyvinyl alcohol and poly vinyl pyrrolidone with oleic acid as the penetration enhancer(5%) were considered as suitable for large scale manufacturing with a backing layer and a suitable adhesive membrane. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=transdermal%20drug%20delivery" title="transdermal drug delivery">transdermal drug delivery</a>, <a href="https://publications.waset.org/abstracts/search?q=penetration%20enhancers" title=" penetration enhancers"> penetration enhancers</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrophilic%20and%20hydrophobic%20polymers" title=" hydrophilic and hydrophobic polymers"> hydrophilic and hydrophobic polymers</a>, <a href="https://publications.waset.org/abstracts/search?q=ondansetron%20HCl" title=" ondansetron HCl"> ondansetron HCl</a> </p> <a href="https://publications.waset.org/abstracts/8874/formulation-and-evaluation-of-tdds-for-sustained-release-ondansetron-hcl-patches" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/8874.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">322</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1042</span> Production of Hydrophilic PVC Surfaces with Microwave Treatment for its Separation from Mixed Plastics by Froth Floatation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Srinivasa%20Reddy%20Mallampati">Srinivasa Reddy Mallampati</a>, <a href="https://publications.waset.org/abstracts/search?q=Chi-Hyeon%20Lee">Chi-Hyeon Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Nguyen%20Thanh%20Truc"> Nguyen Thanh Truc</a>, <a href="https://publications.waset.org/abstracts/search?q=Byeong-Kyu%20Lee"> Byeong-Kyu Lee</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Organic polymeric materials (plastics) are widely used in our daily life and various industrial fields. The separation of waste plastics is important for its feedstock and mechanical recycling. One of the major problems in incineration for thermal recycling or heat melting for material recycling is the polyvinyl chloride (PVC) contained in waste plastics. This is due to the production of hydrogen chloride, chlorine gas, dioxins, and furans originated from PVC. Therefore, the separation of PVC from waste plastics is necessary before recycling. The separation of heavy polymers (PVC 1.42, PMMA 1.12, PC 1.22 and PET 1.27 g/cm3 ) from light ones (PE and PP 0.99 g/cm3) can be achieved on the basis of their density. However it is difficult to separate PVC from other heavy polymers basis of density. There are no simple and inexpensive techniques to separate PVC from others. If hydrophobic the PVC surface is selectively changed into hydrophilic, where other polymers still have hydrophobic surface, flotation process can separate PVC from others. In the present study, the selective surface hydrophilization of polyvinyl chloride (PVC) by microwave treatment after alkaline/acid washing and with activated carbon was studied as the pre-treatment of its separation by the following froth flotation. In presence of activated carbon as absorbent, the microwave treatment could selectively increase the hydrophilicity of the PVC surface (i.e. PVC contact angle decreased about 19o) among other plastics mixture. At this stage, 100% PVC separation from other plastics could be achieved by the combination of the pre- microwave treatment with activated carbon and the following froth floatation. The hydrophilization of PVC by surface analysis would be due to the hydrophilic groups produced by microwave treatment with activated carbon. The effect of optimum condition and detailed mechanism onto separation efficiency in the froth floatation was also investigated. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hydrophilic" title="Hydrophilic">Hydrophilic</a>, <a href="https://publications.waset.org/abstracts/search?q=PVC" title=" PVC"> PVC</a>, <a href="https://publications.waset.org/abstracts/search?q=contact%20angle" title=" contact angle"> contact angle</a>, <a href="https://publications.waset.org/abstracts/search?q=additive" title=" additive"> additive</a>, <a href="https://publications.waset.org/abstracts/search?q=microwave" title=" microwave"> microwave</a>, <a href="https://publications.waset.org/abstracts/search?q=froth%20floatation" title=" froth floatation"> froth floatation</a>, <a href="https://publications.waset.org/abstracts/search?q=waste%20plastics" title=" waste plastics"> waste plastics</a> </p> <a href="https://publications.waset.org/abstracts/26840/production-of-hydrophilic-pvc-surfaces-with-microwave-treatment-for-its-separation-from-mixed-plastics-by-froth-floatation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/26840.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">623</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1041</span> Dissociation of Hydrophobic Interactions in Whey Protein Polymers: Molecular Characterization Using Dilute Solution Viscometry</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ahmed%20S.%20Eissa">Ahmed S. Eissa</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Whey represents about 85-95% of the milk volume and about 55% of milk nutrients. Whey proteins are of special importance in formulated foods due to their rich nutritional and functional benefits. Whey proteins form large polymers upon heating to a temperature greater than the denaturation temperature. Hydrophobic interactions play an important role in building whey protein polymers. In this study, dissociation of hydrophobic interactions of whey protein polymers was done by adding Sodium Dodecyl Sulphonate (SDS). At low SDS concentrations, protein polymers were dissociated to smaller chains, as revealed by dilution solution viscometry (DSV). Interestingly, at higher SDS concentrations, polymer molecules got larger in size. Intrinsic viscosity was increased to many folds when raising the SDS concentration from 0.5% to 2%. Complex molecular arrangement leads to the formation of larger macromolecules, due to micelle formation. The study opens a venue for manipulating and enhancing whey protein functional properties by manipulating the hydrophobic interactions. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=whey%20proteins" title="whey proteins">whey proteins</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrophobic%20interactions" title=" hydrophobic interactions"> hydrophobic interactions</a>, <a href="https://publications.waset.org/abstracts/search?q=SDS" title=" SDS"> SDS</a> </p> <a href="https://publications.waset.org/abstracts/81422/dissociation-of-hydrophobic-interactions-in-whey-protein-polymers-molecular-characterization-using-dilute-solution-viscometry" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/81422.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">248</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1040</span> Learning Materials of Atmospheric Pressure Plasma Process: Turning Hydrophilic Surface to Hydrophobic</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=C.W.%20Kan">C.W. Kan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This paper investigates the use of atmospheric pressure plasma for improving the surface hydrophobicity of polyurethane synthetic leather with tetramethylsilane (TMS). The atmospheric pressure plasma treatment with TMS is a single-step process to enhance the hydrophobicity of polyurethane synthetic leather. The hydrophobicity of the treated surface was examined by contact angle measurement. The physical and chemical surface changes were evaluated by scanning electron microscopy (SEM) and infrared spectroscopy (FTIR). The purpose of this paper is to provide learning materials for understanding how to use atmospheric pressure plasma in the textile finishing process to transform a hydrophilic surface to hydrophobic. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Learning%20materials" title="Learning materials">Learning materials</a>, <a href="https://publications.waset.org/abstracts/search?q=atmospheric%20pressure%20plasma%20treatment" title=" atmospheric pressure plasma treatment"> atmospheric pressure plasma treatment</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrophobic" title=" hydrophobic"> hydrophobic</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrophilic" title=" hydrophilic"> hydrophilic</a>, <a href="https://publications.waset.org/abstracts/search?q=surface" title=" surface"> surface</a> </p> <a href="https://publications.waset.org/abstracts/49534/learning-materials-of-atmospheric-pressure-plasma-process-turning-hydrophilic-surface-to-hydrophobic" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/49534.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">353</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1039</span> Surface Modified Polyvinylidene Fluoride Membranes for Potential Use in Membrane Distillation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Lebea%20Nthunya">Lebea Nthunya</a>, <a href="https://publications.waset.org/abstracts/search?q=Arne%20Verliefde"> Arne Verliefde</a>, <a href="https://publications.waset.org/abstracts/search?q=Bhekie%20Mamba"> Bhekie Mamba</a>, <a href="https://publications.waset.org/abstracts/search?q=Sabelo%20Mhlanga"> Sabelo Mhlanga</a> </p> <p class="card-text"><strong>Abstract:</strong></p> A study aimed at developing membrane distillation (MD) processes that can be used for brackish/saline water purification will be presented. MD is a membrane-based technology that presents a possibility to counteract challenges associated with pressure driven membranes at high separation efficiencies. Membrane distillation membranes (MDM) are affected by wettability and fouling. Wetting inside the pores of the membrane is elevated by the hydrophilic characteristic of the membrane, while fouling is mostly induced by the hydrophobic-hydrophobic interaction of pollutants and the surface of the hydrophobic membranes, hence block the pores of the membranes. These properties are not desirable. As such, a carefully designed polyvinylidene fluoride (PVDF) MDM composed of a super-hydrophobic modified backbone and a super-hydrophilic thin layer has been developed to concurrently overcome these challenges. The membranes were characterized using contact angle measurements to confirm their hydrophobicity/hydrophilicity. SEM and SAXS were used to study the morphology and pore distribution on the surface of the membrane. The contact angles of the active surface ≤ 30º and that of the backbone ≥ 140º has thus revealed that the active surface was highly hydrophilic while the backbone was highly hydrophobic. The SEM and the SAXS results have also confirmed that the membranes are highly porous. These materials demonstrated a potential to remove salts from water at high efficiencies. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=membrane%20distillation" title="membrane distillation">membrane distillation</a>, <a href="https://publications.waset.org/abstracts/search?q=modification" title=" modification"> modification</a>, <a href="https://publications.waset.org/abstracts/search?q=energy%20efficiency" title=" energy efficiency"> energy efficiency</a>, <a href="https://publications.waset.org/abstracts/search?q=desalination" title=" desalination"> desalination</a> </p> <a href="https://publications.waset.org/abstracts/71552/surface-modified-polyvinylidene-fluoride-membranes-for-potential-use-in-membrane-distillation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/71552.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">253</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1038</span> Influence of Surface Wettability on Imbibition Dynamics of Protein Solution in Microwells</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Himani%20Sharma">Himani Sharma</a>, <a href="https://publications.waset.org/abstracts/search?q=Amit%20Agrawal"> Amit Agrawal</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Stability of the Cassie and Wenzel wetting states depends on intrinsic contact angle and geometric features on a surface that was exploited in capturing biofluids in microwells. However, the mechanism of imbibition of biofluids in the microwells is not well implied in terms of wettability of a substrate. In this work, we experimentally demonstrated filling dynamics in hydrophilic and hydrophobic microwells by protein solutions. Towards this, we utilized lotus leaf as a mold to fabricate microwells on a Polydimethylsiloxane (PDMS) surface. Lotus leaf containing micrometer-sized blunt-conical shaped pillars with a height of 8-15 µm and diameter of 3-8 µm were transferred on to PDMS. Furthermore, PDMS surface was treated with oxygen plasma to render the hydrophilic nature. A 10µL droplets containing fluorescein isothiocyanate (FITC) - labelled bovine serum albumin (BSA) were rested on both hydrophobic (θa = 108o, where θa is the apparent contact angle) and hydrophilic (θa = 60o) PDMS surfaces. A time-dependent fluorescence microscopy was conducted on these modified PDMS surfaces by recording the fluorescent intensity over a 5 minute period. It was observed that, initially (at t=1 min) FITC-BSA was accumulated on the periphery of both hydrophilic and hydrophobic microwells due to incomplete penetration of liquid-gas meniscus. This deposition of FITC-BSA on periphery of microwell was not changed with time for hydrophobic surfaces, whereas, a complete filling was occurred in hydrophilic microwells (at t=5 mins). This attributes to a gradual movement of three-phase contact line along the vertical surface of the hydrophilic microwells as compared to stable pinning in the hydrophobic microwells as confirmed by Surface Evolver simulations. In addition, if the cavities are presented on hydrophobic surfaces, air bubbles will be trapped inside the cavities once the aqueous solution is placed over these surfaces, resulting in the Cassie-Baxter wetting state. This condition hinders trapping of proteins inside the microwells. Thus, it is necessary to impart hydrophilicity to the microwell surfaces so as to induce the Wenzel state, such that, an entire solution will be fully in contact with the walls of microwells. Imbibition of microwells by protein solutions was analyzed in terms fluorescent intensity versus time. The present work underlines the importance of geometry of microwells and surface wettability of substrate in wetting and effective capturing of solid sub-phases in biofluids. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=BSA" title="BSA">BSA</a>, <a href="https://publications.waset.org/abstracts/search?q=microwells" title=" microwells"> microwells</a>, <a href="https://publications.waset.org/abstracts/search?q=surface%20evolver" title=" surface evolver"> surface evolver</a>, <a href="https://publications.waset.org/abstracts/search?q=wettability" title=" wettability"> wettability</a> </p> <a href="https://publications.waset.org/abstracts/72888/influence-of-surface-wettability-on-imbibition-dynamics-of-protein-solution-in-microwells" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/72888.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">198</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1037</span> The Potential of Hydrophobically Modified Chitosan Cryogels to Be Used as Drug Delivery Systems</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Courtney%20Evans">Courtney Evans</a>, <a href="https://publications.waset.org/abstracts/search?q=Yuto%20Morimitsu"> Yuto Morimitsu</a>, <a href="https://publications.waset.org/abstracts/search?q=Tsubasa%20Hisadome"> Tsubasa Hisadome</a>, <a href="https://publications.waset.org/abstracts/search?q=Futo%20Inomoto"> Futo Inomoto</a>, <a href="https://publications.waset.org/abstracts/search?q=Masahiro%20Yoshida"> Masahiro Yoshida</a>, <a href="https://publications.waset.org/abstracts/search?q=Takayuki%20Takei"> Takayuki Takei</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Hydrogels are useful biomaterials due to their highly biocompatible nature and their ability to absorb large quantities of liquid and mimic soft tissue. They are often used as therapeutic drug delivery systems. However, it is sometimes difficult to sustain controlled release when using hydrophobic medicines, as hydrogels are frequently hydrophilic. As such, this research shows the success of chitosan hydrogels modified through hydrophobic interaction. This was done through the imide bonding of the alkyl groups in fatty aldehydes and the amino groups in chitosan, followed by reductive animation. The resulting cryogels could be optimized for strength as well as sorption and desorption (of a hydrophobic dye used to mimic hydrophobic medicine) by varying the alkyl chain length and the substitution degree of the fatty aldehyde. Optimized cryogels showed potential as biomedical materials, particularly as drug delivery systems. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=biomedical%20materials" title="biomedical materials">biomedical materials</a>, <a href="https://publications.waset.org/abstracts/search?q=chitosan" title=" chitosan"> chitosan</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20carriers" title=" drug carriers"> drug carriers</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrophobic%20modification" title=" hydrophobic modification"> hydrophobic modification</a> </p> <a href="https://publications.waset.org/abstracts/137406/the-potential-of-hydrophobically-modified-chitosan-cryogels-to-be-used-as-drug-delivery-systems" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/137406.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">234</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1036</span> Effect of Nano-CaCO₃ Addition on the Nano-Mechanical Properties of Cement Paste</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Muzeyyen%20Balcikanli">Muzeyyen Balcikanli</a>, <a href="https://publications.waset.org/abstracts/search?q=Selma%20Ozaslan"> Selma Ozaslan</a>, <a href="https://publications.waset.org/abstracts/search?q=Osman%20Sahin"> Osman Sahin</a>, <a href="https://publications.waset.org/abstracts/search?q=Burak%20Uzal"> Burak Uzal</a>, <a href="https://publications.waset.org/abstracts/search?q=Erdogan%20Ozbay"> Erdogan Ozbay</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this study, the effect of nano-CaCO3 replacement with cement on the nano-mechanical properties of cement paste was investigated. Hydrophobic and hydrophilic characteristics Two types of nano CaCO3 were replaced with Portland cement at 0, 0.5 and 1%. Water to (cement+nano-CaCO3) ratio was kept constant at 0.5 for all mixtures. 36 indentations were applied on each cement paste, and the values of nano-hardness and elastic modulus of cement pastes were determined from the indentation depth-load graphs. Then, by getting the average of them, nano-hardness and elastic modulus were identified for each mixture. Test results illustrate that replacement of hydrophilic n-CaCO3 with cement lead to a significant increase in nano-mechanical properties, however, replacement of hydrophobic n-CaCO3 with cement worsened the nano-mechanical properties considerably. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=nanoindenter" title="nanoindenter">nanoindenter</a>, <a href="https://publications.waset.org/abstracts/search?q=CaCO3" title=" CaCO3"> CaCO3</a>, <a href="https://publications.waset.org/abstracts/search?q=nano-hardness" title=" nano-hardness"> nano-hardness</a>, <a href="https://publications.waset.org/abstracts/search?q=nano-mechanical%20properties" title=" nano-mechanical properties"> nano-mechanical properties</a> </p> <a href="https://publications.waset.org/abstracts/54618/effect-of-nano-caco3-addition-on-the-nano-mechanical-properties-of-cement-paste" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/54618.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">287</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1035</span> Electrokinetic Transport of Power Law Fluid through Hydrophobic Micro-Slits</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ainul%20Haque">Ainul Haque</a>, <a href="https://publications.waset.org/abstracts/search?q=Ameeye%20Kumar%20Nayak"> Ameeye Kumar Nayak</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Flow enhancement and species transport in a slit hydrophobic microchannel is studied for non-Newtonian fluids with the externally imposed electric field and pressure gradient. The incompressible Poisson-Nernst-Plank equations and the Navier-Stokes equations are approximated by lubrication theory to quantify the flow structure due to hydrophobic and hydrophilic surfaces. The analytical quantification of velocity and pressure of electroosmotic flow (EOF) is made with the numerical results due to the staggered grid based finite volume method for flow governing equations. The resistance force due to fluid friction and shear force along the surface are decreased by the hydrophobicity, enables the faster movement of fluid particles. The resulting flow enhancement factor Ef is increased with the low viscous fluid and provides maximum species transport. Also, the analytical comparison of EOF with pressure driven EOF justifies the flow enhancement due to hydrophobicity and shear impact on flow variation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=electroosmotic%20flow" title="electroosmotic flow">electroosmotic flow</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrophobic%20surface" title=" hydrophobic surface"> hydrophobic surface</a>, <a href="https://publications.waset.org/abstracts/search?q=power-law%20fluid" title=" power-law fluid"> power-law fluid</a>, <a href="https://publications.waset.org/abstracts/search?q=shear%20effect" title=" shear effect"> shear effect</a> </p> <a href="https://publications.waset.org/abstracts/81689/electrokinetic-transport-of-power-law-fluid-through-hydrophobic-micro-slits" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/81689.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">377</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1034</span> Nanopharmaceutical: A Comprehensive Appearance of Drug Delivery System</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mahsa%20Fathollahzadeh">Mahsa Fathollahzadeh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The various nanoparticles employed in drug delivery applications include micelles, liposomes, solid lipid nanoparticles, polymeric nanoparticles, functionalized nanoparticles, nanocrystals, cyclodextrins, dendrimers, and nanotubes. Micelles, composed of amphiphilic block copolymers, can encapsulate hydrophobic molecules, allowing for targeted delivery. Liposomes, vesicular structures made up of phospholipids, can encapsulate both hydrophobic and hydrophilic molecules, providing a flexible platform for delivering therapeutic agents. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) are designed to improve the stability and bioavailability of lipophilic drugs. Polymeric nanoparticles, such as poly(lactic-co-glycolic acid) (PLGA), are biodegradable and can be engineered to release drugs in a controlled manner. Functionalized nanoparticles, coated with targeting ligands or antibodies, can specifically target diseased cells or tissues. Nanocrystals, engineered to have specific surface properties, can enhance the solubility and bioavailability of poorly soluble drugs. Cyclodextrins, doughnut-shaped molecules with hydrophobic cavities, can be complex with hydrophobic molecules, allowing for improved solubility and bioavailability. Dendrimers, branched polymers with a central core, can be designed to deliver multiple therapeutic agents simultaneously. Nanotubes and metallic nanoparticles, such as gold nanoparticles, offer real-time tracking capabilities and can be used to detect biomolecular interactions. The use of these nanoparticles has revolutionized the field of drug delivery, enabling targeted and controlled release of therapeutic agents, reduced toxicity, and improved patient outcomes. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=nanotechnology" title="nanotechnology">nanotechnology</a>, <a href="https://publications.waset.org/abstracts/search?q=nanopharmaceuticals" title=" nanopharmaceuticals"> nanopharmaceuticals</a>, <a href="https://publications.waset.org/abstracts/search?q=drug-delivery" title=" drug-delivery"> drug-delivery</a>, <a href="https://publications.waset.org/abstracts/search?q=proteins" title=" proteins"> proteins</a>, <a href="https://publications.waset.org/abstracts/search?q=ligands" title=" ligands"> ligands</a>, <a href="https://publications.waset.org/abstracts/search?q=nanoparticles" title=" nanoparticles"> nanoparticles</a>, <a href="https://publications.waset.org/abstracts/search?q=chemistry" title=" chemistry"> chemistry</a> </p> <a href="https://publications.waset.org/abstracts/186065/nanopharmaceutical-a-comprehensive-appearance-of-drug-delivery-system" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/186065.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">51</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1033</span> Fluorination Renders the Wood Surface Hydrophobic without Any Loos of Physical and Mechanical Properties</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Martial%20Pouzet">Martial Pouzet</a>, <a href="https://publications.waset.org/abstracts/search?q=Marc%20Dubois"> Marc Dubois</a>, <a href="https://publications.waset.org/abstracts/search?q=Karine%20Charlet"> Karine Charlet</a>, <a href="https://publications.waset.org/abstracts/search?q=Alexis%20B%C3%A9akou"> Alexis Béakou</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The availability, the ecologic and economic characteristics of wood are advantages which explain the very wide scope of applications of this material, in several domains such as paper industry, furniture, carpentry and building. However, wood is a hygroscopic material highly sensitive to ambient humidity and temperature. The swelling and the shrinking caused by water absorption and desorption cycles lead to crack and deformation in the wood volume, making it incompatible for such applications. In this study, dynamic fluorination using F2 gas was applied to wood samples (douglas and silver fir species) to decrease their hydrophilic character. The covalent grafting of fluorine atoms onto wood surface through a conversion of C-OH group into C-F was validated by Fourier-Transform infrared spectroscopy and 19F solid state Nuclear Magnetic Resonance. It revealed that the wood, which is initially hydrophilic, acquired a hydrophobic character comparable to that of the Teflon, thanks to fluorination. A good durability of this treatment was also determined by aging tests under ambient atmosphere and under UV irradiation. Moreover, this treatment allowed obtaining hydrophobic character without major structural (morphology, density and colour) or mechanical changes. The maintaining of these properties after fluorination, which requires neither toxic solvent nor heating, appears as a remarkable advantage over other more traditional physical and chemical wood treatments. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cellulose" title="cellulose">cellulose</a>, <a href="https://publications.waset.org/abstracts/search?q=spectroscopy" title=" spectroscopy"> spectroscopy</a>, <a href="https://publications.waset.org/abstracts/search?q=surface%20treatment" title=" surface treatment"> surface treatment</a>, <a href="https://publications.waset.org/abstracts/search?q=water%20absorption" title=" water absorption"> water absorption</a> </p> <a href="https://publications.waset.org/abstracts/72715/fluorination-renders-the-wood-surface-hydrophobic-without-any-loos-of-physical-and-mechanical-properties" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/72715.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">202</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1032</span> Modification of Polyolefin Membrane Using Supercritical Carbon Dioxide for Redox Flow Batteries</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Vadim%20V.%20Zefirov">Vadim V. Zefirov</a>, <a href="https://publications.waset.org/abstracts/search?q=Victor%20E.%20Sizov"> Victor E. Sizov</a>, <a href="https://publications.waset.org/abstracts/search?q=Marina%20A.%20Pigaleva"> Marina A. Pigaleva</a>, <a href="https://publications.waset.org/abstracts/search?q=Igor%20V.%20Elmanovich"> Igor V. Elmanovich</a>, <a href="https://publications.waset.org/abstracts/search?q=Mikhail%20S.%20Kondratenko"> Mikhail S. Kondratenko</a>, <a href="https://publications.waset.org/abstracts/search?q=Marat%20O.%20Gallyamov"> Marat O. Gallyamov</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This work presents a novel method for treating porous hydrophobic polyolefin membranes using supercritical carbon dioxide that allows usage of the modified membrane in redox flow batteries with an aqueous electrolyte. Polyolefin membranes are well known and widely used, however, they cannot be used as separators in redox flow batteries with an aqueous electrolyte since they have insufficient wettability, and therefore do not provide sufficient proton conductivity. The main aim of the presented work was the development of hydrophilic composites based on cheap membranes and precursors. Supercritical fluid was used as a medium for the deposition of the hydrophilic phase on the hydrophobic surface of the membrane. Due to the absence of negative capillary effects in a supercritical medium, a homogeneous composite is obtained as a result of synthesis. The in-situ synthesized silicon oxide nanoparticles and the chitosan polymer layer act as the hydrophilic phase and not only increase the affinity of the membrane towards the electrolyte, but also reduce the pore size of the polymer matrix, which positively affects the ion selectivity of the membrane. The composite material obtained as a result of synthesis has enhanced hydrophilic properties and is capable of providing proton conductivity in redox flow batteries. The morphology of the obtained composites was characterized by electron microscopy. To analyze the phase composition, infrared spectroscopy was used. The hydrophilic properties were studied by water contact angle measurements. In addition, the proton conductivity and ion selectivity of the obtained samples were studied, and tests in real redox flow batteries were performed. As a result, modified membrane was characterised in detail and moreover it was shown that modified cheap polyolefin membranes have pronounced proton conductivity and high ion selectivity, so their performance in a real redox flow battery approaches expensive commercial analogues, reaching 70% of energy efficiency. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=carbon%20dioxide" title="carbon dioxide">carbon dioxide</a>, <a href="https://publications.waset.org/abstracts/search?q=chitosan" title=" chitosan"> chitosan</a>, <a href="https://publications.waset.org/abstracts/search?q=polymer%20membrane" title=" polymer membrane"> polymer membrane</a>, <a href="https://publications.waset.org/abstracts/search?q=redox%20flow%20batteries" title=" redox flow batteries"> redox flow batteries</a>, <a href="https://publications.waset.org/abstracts/search?q=silica%20nanoparticles" title=" silica nanoparticles"> silica nanoparticles</a>, <a href="https://publications.waset.org/abstracts/search?q=supercritical%20fluid" title=" supercritical fluid "> supercritical fluid </a> </p> <a href="https://publications.waset.org/abstracts/122125/modification-of-polyolefin-membrane-using-supercritical-carbon-dioxide-for-redox-flow-batteries" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/122125.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">153</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1031</span> Interfacial Adhesion and Properties Improvement of Polyethylene/Thermoplastic Starch Blend Compatibilized by Stearic Acid-Grafted-Starch</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nattaporn%20Khanoonkon">Nattaporn Khanoonkon</a>, <a href="https://publications.waset.org/abstracts/search?q=Rangrong%20Yoksan"> Rangrong Yoksan</a>, <a href="https://publications.waset.org/abstracts/search?q=Amod%20A.%20Ogale"> Amod A. Ogale</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Polyethylene (PE) is one of the most petroleum-based thermoplastic materials used in many applications including packaging due to its cheap, light-weight, chemically inert and capable to be converted into various shapes and sizes of products. Although PE is a commercially potential material, its non-biodegradability caused environmental problems. At present, bio-based polymers become more interesting owing to its bio-degradability, non-toxicity, and renewability as well as being eco-friendly. Thermoplastic starch (TPS) is a bio-based and biodegradable plastic produced from the plasticization of starch under applying heat and shear force. In many researches, TPS was blended with petroleum-based polymers including PE in order to reduce the cost and the use of those polymers. However, the phase separation between hydrophobic PE and hydrophilic TPS limited the amount of TPS incorporated. The immiscibility of two different polarity polymers can be diminished by adding compatibilizer. PE-based compatibilizers, e.g. polyethylene-grafted-maleic anhydride, polyethylene-co-vinyl alcohol, etc. have been applied for the PE/TPS blend system in order to improve their miscibility. Until now, there is no report about the utilization of starch-based compatibilizer for PE/TPS blend system. The aims of the present research were therefore to synthesize a new starch-based compatibilizer, i.e. stearic acid-grafted starch (SA-g-starch) and to study the effect of SA-g-starch on chemical interaction, morphological properties, tensile properties and water vapor as well as oxygen barrier properties of the PE/TPS blend films. PE/TPS blends without and with incorporating SA-g-starch with a content of 1, 3 and 5 part(s) per hundred parts of starch (phr) were prepared using a twin screw extruder and then blown into films using a film blowing machine. Incorporating 1 phr and 3 phr of SA-g-starch could improve miscibility of the two polymers as confirmed from the reduction of TPS phase size and the good dispersion of TPS phase in PE matrix. In addition, the blend containing SA-g-starch with contents of 1 phr and 3 phr exhibited higher tensile strength and extensibility, as well as lower water vapor and oxygen permeabilities than the naked blend. The above results suggested that SA-g-starch could be potentially applied as a compatibilizer for the PE/TPS blend system. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=blend" title="blend">blend</a>, <a href="https://publications.waset.org/abstracts/search?q=compatibilizer" title=" compatibilizer"> compatibilizer</a>, <a href="https://publications.waset.org/abstracts/search?q=polyethylene" title=" polyethylene"> polyethylene</a>, <a href="https://publications.waset.org/abstracts/search?q=thermoplastic%20starch" title=" thermoplastic starch"> thermoplastic starch</a> </p> <a href="https://publications.waset.org/abstracts/28960/interfacial-adhesion-and-properties-improvement-of-polyethylenethermoplastic-starch-blend-compatibilized-by-stearic-acid-grafted-starch" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/28960.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">440</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1030</span> Drug Delivery Nanoparticles of Amino Acid Based Biodegradable Polymers </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sophio%20Kobauri">Sophio Kobauri</a>, <a href="https://publications.waset.org/abstracts/search?q=Tengiz%20Kantaria"> Tengiz Kantaria</a>, <a href="https://publications.waset.org/abstracts/search?q=Temur%20Kantaria"> Temur Kantaria</a>, <a href="https://publications.waset.org/abstracts/search?q=David%20Tugushi"> David Tugushi</a>, <a href="https://publications.waset.org/abstracts/search?q=Nina%20Kulikova"> Nina Kulikova</a>, <a href="https://publications.waset.org/abstracts/search?q=Ramaz%20Katsarava"> Ramaz Katsarava</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Nanosized environmentally responsive materials are of special interest for various applications, including targeted drug to a considerable potential for treatment of many human diseases. The important technological advantages of nanoparticles (NPs) usage as drug carriers (nanocontainers) are their high stability, high carrier capacity, feasibility of encapsulation of both hydrophilic or hydrophobic substances, as well as a high variety of possible administration routes, including oral application and inhalation. NPs can also be designed to allow controlled (sustained) drug release from the matrix. These properties of NPs enable improvement of drug bioavailability and might allow drug dosage decrease. The targeted and controlled administration of drugs using NPs might also help to overcome drug resistance, which is one of the major obstacles in the control of epidemics. Various degradable and non-degradable polymers of both natural and synthetic origin have been used for NPs construction. One of the most promising for the design of NPs are amino acid-based biodegradable polymers (AABBPs) which can clear from the body after the fulfillment of their function. The AABBPs are composed of naturally occurring and non-toxic building blocks such as α-amino acids, fatty diols and dicarboxylic acids. The particles designed from these polymers are expected to have an improved bioavailability along with a high biocompatibility. The present work deals with a systematic study of the preparation of NPs by cost-effective polymer deposition/solvent displacement method using AABBPs. The influence of the nature and concentration of surfactants, concentration of organic phase (polymer solution), and the ratio organic phase/inorganic (water) phase, as well as of some other factors on the size of the fabricated NPs have been studied. It was established that depending on the used conditions the NPs size could be tuned within 40-330 nm. As the next step of this research an evaluation of biocompatibility and bioavailability of the synthesized NPs has been performed, using two stable human cell culture lines – HeLa and A549. This part of study is still in progress now. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=amino%20acids" title="amino acids">amino acids</a>, <a href="https://publications.waset.org/abstracts/search?q=biodegradable%20polymers" title=" biodegradable polymers"> biodegradable polymers</a>, <a href="https://publications.waset.org/abstracts/search?q=nanoparticles%20%28NPs%29" title=" nanoparticles (NPs)"> nanoparticles (NPs)</a>, <a href="https://publications.waset.org/abstracts/search?q=non-toxic%20building%20blocks" title=" non-toxic building blocks"> non-toxic building blocks</a> </p> <a href="https://publications.waset.org/abstracts/33782/drug-delivery-nanoparticles-of-amino-acid-based-biodegradable-polymers" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/33782.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">432</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1029</span> Wetting Treatement: Comparative Overview: Case of Polypropylene Top Sheet Layer on Disposable Baby Diaper</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Tilouche%20Rahma">Tilouche Rahma</a>, <a href="https://publications.waset.org/abstracts/search?q=Sayeb%20Soumaya"> Sayeb Soumaya</a>, <a href="https://publications.waset.org/abstracts/search?q=Ben%20Hassen%20Mohamed"> Ben Hassen Mohamed</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The wettability of materials is a very important aspect of surface science, it presents a key factor providing the best characteristic of product, especially in hygienic field. Hydrophobic polypropylene is used as nonwoven topsheet in disposable diaper, for its interesting properties (toughness, lightness...) by comparing with traditional product previously used. SURFACTANTs are widely used to reduce contact angle (water contact angles larger than 90° on smooth surfaces) and to change wetting properties. In the present work, we study ways to obtain hydrophilic polypropylene surface, by the deposition of a variety of surfactant on surfaces of varying morphology. We used two different methods for surface wetting: Spraying method and the coating method. The concentration of the wetting agent, the type of non-woven fabric and the parameters in the method for controlling, hugely affect the quality of treatment. Therefore need that the treatment is effective in terms of contact angle without affecting the mechanical properties of the nonwoven. For the assessment of the quality of treatment, two methods are used: The measurement of the contact angle and the strike trough time. Also, with subjective evaluation by Hedonic test (which involves the consumer preference (naive panel: group of moms). Finally, we selected the better treated topsheet referring to the assessment results. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=SURFACTANT" title="SURFACTANT">SURFACTANT</a>, <a href="https://publications.waset.org/abstracts/search?q=topsheet%20polypropylene" title=" topsheet polypropylene"> topsheet polypropylene</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrophilic" title=" hydrophilic"> hydrophilic</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrophobic" title=" hydrophobic"> hydrophobic</a> </p> <a href="https://publications.waset.org/abstracts/27947/wetting-treatement-comparative-overview-case-of-polypropylene-top-sheet-layer-on-disposable-baby-diaper" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/27947.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">545</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1028</span> Nanoparticles Made of Amino Acid Derived Biodegradable Polymers as Promising Drug Delivery Containers</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sophio%20Kobauri">Sophio Kobauri</a>, <a href="https://publications.waset.org/abstracts/search?q=Tengiz%20Kantaria"> Tengiz Kantaria</a>, <a href="https://publications.waset.org/abstracts/search?q=Temur%20Kantaria"> Temur Kantaria</a>, <a href="https://publications.waset.org/abstracts/search?q=David%20Tugushi"> David Tugushi</a>, <a href="https://publications.waset.org/abstracts/search?q=Nina%20Kulikova"> Nina Kulikova</a>, <a href="https://publications.waset.org/abstracts/search?q=Ramaz%20Katsarava"> Ramaz Katsarava</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Polymeric disperse systems such as nanoparticles (NPs) are of high interest for numerous applications in contemporary medicine and nanobiotechnology to a considerable potential for treatment of many human diseases. The important technological advantages of NPs usage as drug carriers (nanocontainers) are their high stability, high carrier capacity, feasibility of encapsulation of both hydrophilic or hydrophobic substances, as well as a high variety of possible administration routes, including oral application and inhalation. NPs can also be designed to allow controlled (sustained) drug release from the matrix. These properties of NPs enable improvement of drug bioavailability and might allow drug dosage decrease. The targeted and controlled administration of drugs using NPs might also help to overcome drug resistance, which is one of the major obstacles in the control of epidemics. Various degradable and non-degradable polymers of both natural and synthetic origin have been used for NPs construction. One of the most promising for the design of NPs are amino acid-based biodegradable polymers (AABBPs) which can clear from the body after the fulfillment of their function. The AABBPs are composed of naturally occurring and non-toxic building blocks such as α-amino acids, fatty diols and dicarboxylic acids. The particles designed from these polymers are expected to have an improved bioavailability along with a high biocompatibility. The present work deals with a systematic study of the preparation of NPs by cost-effective polymer deposition/solvent displacement method using AABBPs. The influence of the nature and concentration of surfactants, concentration of organic phase (polymer solution), and the ratio organic phase/inorganic(water) phase, as well as of some other factors on the size of the fabricated NPs have been studied. It was established that depending on the used conditions the NPs size could be tuned within 40-330 nm. At the next step of this research was carried out an evaluation of biocompability and bioavailability of the synthesized NPs using a stable human cell culture line – A549. It was established that the obtained NPs are not only biocompatible but they stimulate the cell growth. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=amino%20acids" title="amino acids">amino acids</a>, <a href="https://publications.waset.org/abstracts/search?q=biodegradable%20polymers" title=" biodegradable polymers"> biodegradable polymers</a>, <a href="https://publications.waset.org/abstracts/search?q=bioavailability" title=" bioavailability"> bioavailability</a>, <a href="https://publications.waset.org/abstracts/search?q=nanoparticles" title=" nanoparticles"> nanoparticles</a> </p> <a href="https://publications.waset.org/abstracts/47745/nanoparticles-made-of-amino-acid-derived-biodegradable-polymers-as-promising-drug-delivery-containers" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/47745.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">298</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1027</span> Polymersomes in Drug Delivery: A Comparative Review with Liposomes and Micelles</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Salma%20E.%20Ahmed">Salma E. Ahmed</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Since the mid 50’s, enormous attention has been paid towards nanocarriers and their applications in drug and gene delivery. Among these vesicles, liposomes and micelles have been heavily investigated due to their many advantages over other types. Liposomes, for instance, are mostly distinguished by their ability to encapsulate hydrophobic, hydrophilic and amphiphilic drugs. Micelles, on the other hand, are self-assembled shells of lipids, amphiphilic or oppositely charged block copolymers that, once exposed to aqueous media, can entrap hydrophobic agents, and possess prolonged circulation in the bloodstream. Both carriers are considered compatible and biodegradable. Nevertheless, they have limited stabilities, chemical versatilities, and drug encapsulation efficiencies. In order to overcome these downsides, strategies for optimizing a novel drug delivery system that has the architecture of liposomes and polymeric characteristics of micelles have been evolved. Polymersomes are vehicles with fluidic cores and hydrophobic shells that are protected and isolated from the aqueous media by the hydrated hydrophilic brushes which give the carrier its distinctive polymeric bilayer shape. Similar to liposomes, this merit enables the carrier to encapsulate a wide range of agents, despite their affinities and solubilities in water. Adding to this, the high molecular weight of the amphiphiles that build the body of the polymersomes increases their colloidal and chemical stabilities and reduces the permeability of the polymeric membranes, which makes the vesicles more protective to the encapsulated drug. These carriers can also be modified in ways that make them responsive when targeted or triggered, by manipulating their composition and attaching moieties and conjugates to the body of the carriers. These appealing characteristics, in addition to the ease of synthesis, gave the polymersomes greater potentials in the area of drug delivery. Thus, their design and characterization, in comparison with liposomes and micelles, are briefly reviewed in this work. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=controlled%20release" title="controlled release">controlled release</a>, <a href="https://publications.waset.org/abstracts/search?q=liposomes" title=" liposomes"> liposomes</a>, <a href="https://publications.waset.org/abstracts/search?q=micelles" title=" micelles"> micelles</a>, <a href="https://publications.waset.org/abstracts/search?q=polymersomes" title=" polymersomes"> polymersomes</a>, <a href="https://publications.waset.org/abstracts/search?q=targeting" title=" targeting"> targeting</a> </p> <a href="https://publications.waset.org/abstracts/67371/polymersomes-in-drug-delivery-a-comparative-review-with-liposomes-and-micelles" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/67371.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">195</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1026</span> Preliminary Studies on Poloxamer-Based Hydrogels with Oregano Essential Oil as Potential Topical Treatment of Cutaneous Papillomas</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ana%20Maria%20Mu%C8%9B">Ana Maria Muț</a>, <a href="https://publications.waset.org/abstracts/search?q=Georgeta%20Coneac"> Georgeta Coneac</a>, <a href="https://publications.waset.org/abstracts/search?q=Ioana%20Olariu"> Ioana Olariu</a>, <a href="https://publications.waset.org/abstracts/search?q=%C8%98tefana%20Avram"> Ștefana Avram</a>, <a href="https://publications.waset.org/abstracts/search?q=Ioana%20Zinuca%20Pavel"> Ioana Zinuca Pavel</a>, <a href="https://publications.waset.org/abstracts/search?q=Ionela%20Daliana%20Minda"> Ionela Daliana Minda</a>, <a href="https://publications.waset.org/abstracts/search?q=Lavinia%20Vlaia"> Lavinia Vlaia</a>, <a href="https://publications.waset.org/abstracts/search?q=Cristina%20Adriana%20Dehelean"> Cristina Adriana Dehelean</a>, <a href="https://publications.waset.org/abstracts/search?q=Corina%20Danciu"> Corina Danciu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Oregano essential oil is obtained from different parts of the plant Origanum vulgare (fam. Lamiaceae) and carvacrol and thymol are primary components, widely recognized for their antimicrobial activity, as well as their antiviral and antifungal properties. Poloxamers are triblock copolymers (Pluronic®), formed of three non-ionic blocks with a hydrophobic polyoxypropylene central chain flanked by two polyoxyethylene hydrophilic chains. They are known for their biocompatibility, sensitivity to temperature changes (sol-to-gel transition of aqueous solution with temperature increase), but also for their amphiphilic and surface active nature determining the formation of micelles, useful for solubilization of different hydrophobic compounds such as the terpenes and terpenoids contained in essential oils. Thus, these polymers, listed in European and US Pharmacopoeia and approved by FDA, are widely used as solubilizers and gelling agents for various pharmaceutical preparations, including topical hydrogels. The aim of this study was to investigate the posibility of solubilizing oregano essential oil (OEO) in polymeric micelles using polyoxypropylene (PPO)-polyoxyethylene (PEO)-polyoxypropylene (PPO) triblock polymers to obtain semisolid systems suitable for topical application. A formulation screening was performed, using Pluronic® F-127 in concentration of 20%, Pluronic® L-31, Pluronic® L-61 and Pluronic® L-62 in concentration of 0.5%, 0.8% respectively 1% to obtain the polymeric micelles-based systems. Then, to each selected system, with or without 10% absolute ethanol, 5% or 8% OEO was added. The obtained transparent poloxamer-based hydrogels containing solubilized OEO were further evaluated for pH, rheological characteristics (flow behaviour, viscosity, consistency and spreadability), using consacrated techniques like potentiometric titration, stationary shear flow test, penetrometric method and parallel plate method. Also, in vitro release and permeation of carvacrol from the hydrogels was carried out, using vertical diffusion cells and synthetic hydrophilic membrane and porcine skin respectively. The pH values and rheological features of all tested formulations were in accordance with official requirements for semisolid cutaneous preparations. But, the formulation containing 0.8% Pluronic® L-31, 10% absolute ethanol, 8% OEO and water and the formulation with 1% Pluronic® L-31, 5% OEO and water, produced the highest cumulative amounts of carvacrol released/permeated through the membrane. The present study demonstrated that oregano essential oil can be successfully solubilized in the investigated poloxamer-based hydrogels. These systems can be further investigated as potential topical therapy for cutaneous papillomas. Funding: This research was funded by Project PN-III-P1-1.1-TE2019-0130, Contract number TE47, Romania. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=oregano%20essential%20oil" title="oregano essential oil">oregano essential oil</a>, <a href="https://publications.waset.org/abstracts/search?q=carvacrol" title=" carvacrol"> carvacrol</a>, <a href="https://publications.waset.org/abstracts/search?q=poloxamer" title=" poloxamer"> poloxamer</a>, <a href="https://publications.waset.org/abstracts/search?q=topical%20hydrogels" title=" topical hydrogels"> topical hydrogels</a> </p> <a href="https://publications.waset.org/abstracts/150229/preliminary-studies-on-poloxamer-based-hydrogels-with-oregano-essential-oil-as-potential-topical-treatment-of-cutaneous-papillomas" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/150229.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">113</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1025</span> Ecofriendly Multi-Layer Polymer Treatment for Hydrophobic and Water Repellent Porous Cotton Fabrics</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Muhammad%20Zahid">Muhammad Zahid</a>, <a href="https://publications.waset.org/abstracts/search?q=Ilker%20S.%20Bayer"> Ilker S. Bayer</a>, <a href="https://publications.waset.org/abstracts/search?q=Athanassia%20Athanassiou"> Athanassia Athanassiou</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Fluorinated polymers having C8 chemistry (chemicals with 8 fluorinated carbon atoms) are well renowned for their excellent low surface tension and water repelling properties. However, these polymers degrade into highly toxic heavy perfluoro acids in the environment. When the C8 chemistry is reduced to C6 chemistry, this environmental concern is eliminated at the expense of reduced liquid repellent performance. In order to circumvent this, in this study, we demonstrate pre-treatment of woven cotton fabrics with a fluorinated acrylic copolymer with C6 chemistry and subsequently with a silicone polymer to render them hydrophobic. A commercial fluorinated acrylic copolymer was blended with silica nanoparticles to form hydrophobic nano-roughness on cotton fibers and a second coating layer of polydimethylsiloxane (PDMS) was applied on the fabric. A static water contact angle (for 5µl) and rolling angle (for 12.5µl) of 147°±2° and 31° were observed, respectively. Hydrostatic head measurements were also performed to better understand the performance with 26±1 cm and 2.56kPa column height and static pressure respectively. Fabrication methods (with rod coater etc.) were kept simple, reproducible, and scalable and cost efficient. Moreover, the robustness of applied coatings was also evaluated by sonication cleaning and abrasion methods. Water contact angle (WCA), water shedding angle (WSA), hydrostatic head, droplet bouncing-rolling off and prolonged staining tests were used to characterize hydrophobicity of materials. For chemical and morphological analysis, various characterization methods were used such as attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), atomic force microscopy (AFM) and scanning electron microscopy (SEM). <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=fluorinated%20polymer" title="fluorinated polymer">fluorinated polymer</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrophobic" title=" hydrophobic"> hydrophobic</a>, <a href="https://publications.waset.org/abstracts/search?q=polydimethylsiloxane" title=" polydimethylsiloxane"> polydimethylsiloxane</a>, <a href="https://publications.waset.org/abstracts/search?q=water%20contact%20angle" title=" water contact angle"> water contact angle</a> </p> <a href="https://publications.waset.org/abstracts/56381/ecofriendly-multi-layer-polymer-treatment-for-hydrophobic-and-water-repellent-porous-cotton-fabrics" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/56381.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">325</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1024</span> pH and Temperature Triggered Release of Doxorubicin from Hydogen Bonded Multilayer Films of Polyoxazolines</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Meltem%20Haktaniyan">Meltem Haktaniyan</a>, <a href="https://publications.waset.org/abstracts/search?q=Eda%20Cagli"> Eda Cagli</a>, <a href="https://publications.waset.org/abstracts/search?q=Irem%20Erel%20Goktepe"> Irem Erel Goktepe</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Polymers that change their properties in response to different stimuli (e.g. light, temperature, pH, ionic strength or magnetic field) are called ‘smart’ or ‘stimuli-responsive polymers’. These polymers have been widely used in biomedical applications such as sensors, gene delivery, drug delivery or tissue engineering. Temperature-responsive polymers have been studied extensively for controlled drug delivery applications. As regard of pseudo-peptides, poly (2-alky-2-oxazoline)s are considered as good candidates for delivery systems due to their stealth behavior and nontoxicity. In order to build responsive multilayer films for controlled drug release applications from surface, Layer by layer technique (LBL) is a powerful technique with an advantage of nanometer scale control over spatial architecture and morphology. Multilayers can be constructed on surface where non-covalent interactions including electrostatic interactions, hydrogen bonding, and charge-transfer or hydrophobic-hydrophobic interactions. In the present study, hydrogen bounded multilayer films of poly (2-alky-2-oxazoline) s with tannic acid were prepared in order to use as a platform to release Doxorubicin (DOX) from surface with pH and thermal triggers. For this purpose, poly (2-isopropyl-2-oxazoline) (PIPOX) and poly (2-ethyl-2-oxazoline) (PETOX) were synthesized via cationic ring opening polymerization (CROP) with hydroxyl end groups. Two polymeric multilayer systems ((PETOX)/(DOX)-(TA) complexes and (PIPOX)/(DOX)-(TA) complexes) were designed to investigate of controlled release of Doxorubicin (DOX) from surface with pH and thermal triggers. The drug release profiles from the multilayer thin films with alterations of pH and temperature will been examined with UV-Vis Spectroscopy and Fluorescence Spectroscopy. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=temperature%20responsive%20polymers" title="temperature responsive polymers">temperature responsive polymers</a>, <a href="https://publications.waset.org/abstracts/search?q=h-bonded%20multilayer%20films" title=" h-bonded multilayer films"> h-bonded multilayer films</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20release" title=" drug release"> drug release</a>, <a href="https://publications.waset.org/abstracts/search?q=polyoxazoline" title=" polyoxazoline"> polyoxazoline</a> </p> <a href="https://publications.waset.org/abstracts/44688/ph-and-temperature-triggered-release-of-doxorubicin-from-hydogen-bonded-multilayer-films-of-polyoxazolines" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/44688.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">308</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1023</span> Preliminary Studies of Antibiofouling Properties in Wrinkled Hydrogel Surfaces</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mauricio%20A.%20Sarabia-Vallejos">Mauricio A. Sarabia-Vallejos</a>, <a href="https://publications.waset.org/abstracts/search?q=Carmen%20M.%20Gonzalez-Henriquez"> Carmen M. Gonzalez-Henriquez</a>, <a href="https://publications.waset.org/abstracts/search?q=Adolfo%20Del%20Campo-Garcia"> Adolfo Del Campo-Garcia</a>, <a href="https://publications.waset.org/abstracts/search?q=Aitzibier%20L.%20Cortajarena"> Aitzibier L. Cortajarena</a>, <a href="https://publications.waset.org/abstracts/search?q=Juan%20Rodriguez-Hernandez"> Juan Rodriguez-Hernandez</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this study, it was explored the formation and the morphological differences between wrinkled hydrogel patterns obtained via generation of surface instabilities. The slight variations in the polymerization conditions produce important changes in the material composition and pattern structuration. The compounds were synthesized using three main components, i.e. an amphiphilic monomer, hydroxyethyl methacrylate (HEMA), a hydrophobic monomer, trifluoroethyl methacrylate (TFMA), and a hydrophilic crosslinking agent, poly(ethylene glycol) diacrylate (PEGDA). The first part of this study was related to the formation of wrinkled surfaces using only HEMA and PEGDA and varying the amount of water added in the reaction. The second part of this study involves the gradual insertion of TFMA into the hydrophilic reaction mixture. Interestingly, the manipulation of the chemical composition of this hydrogel affects both surface morphology and physicochemical characteristics of the patterns, inducing transitions from one particular type of structure (wrinkles or ripples) to different ones (creases, folds, and crumples). Contact angle measurements show that the insertion of TFMA produces a slight decrease in surface wettability of the samples, remaining however highly hydrophilic (contact angle below 45°). More interestingly, by using confocal Raman spectroscopy, important information about the wrinkle formation mechanism is obtained. The procedure involving two consecutive thermal and photopolymerization steps lead to a “pseudo” two-layer system. Thus, upon photopolymerization, the surface is crosslinked to a higher extent than the bulk and water evaporation drives the formation of wrinkled surfaces. Finally, cellular, and bacterial proliferation studies were performed to the samples, showing that the amount of TFMA included in each sample slightly affects the proliferation of both (bacteria and cells), but in the case of bacteria, the morphology of the sample also plays an important role, importantly reducing the bacterial proliferation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antibiofouling%20properties" title="antibiofouling properties">antibiofouling properties</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrophobic%2Fhydrophilic%20balance" title=" hydrophobic/hydrophilic balance"> hydrophobic/hydrophilic balance</a>, <a href="https://publications.waset.org/abstracts/search?q=morphologic%20characterization" title=" morphologic characterization"> morphologic characterization</a>, <a href="https://publications.waset.org/abstracts/search?q=wrinkled%20hydrogel%20patterns" title=" wrinkled hydrogel patterns"> wrinkled hydrogel patterns</a> </p> <a href="https://publications.waset.org/abstracts/84760/preliminary-studies-of-antibiofouling-properties-in-wrinkled-hydrogel-surfaces" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/84760.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">163</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1022</span> Synthesis and Characterization of Sulfonated Aromatic Hydrocarbon Polymers Containing Trifluoromethylphenyl Side Chain for Proton Exchange Membrane Fuel Cell</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Yi-Chiang%20Huang">Yi-Chiang Huang</a>, <a href="https://publications.waset.org/abstracts/search?q=Hsu-Feng%20Lee"> Hsu-Feng Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Yu-Chao%20Tseng"> Yu-Chao Tseng</a>, <a href="https://publications.waset.org/abstracts/search?q=Wen-Yao%20Huang"> Wen-Yao Huang</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Proton exchange membranes as a key component in fuel cells have been widely studying over the past few decades. As proton exchange, membranes should have some main characteristics, such as good mechanical properties, low oxidative stability and high proton conductivity. In this work, trifluoromethyl groups had been introduced on polymer backbone and phenyl side chain which can provide densely located sulfonic acid group substitution and also promotes solubility, thermal and oxidative stability. Herein, a series of novel sulfonated aromatic hydrocarbon polyelectrolytes was synthesized by polycondensation of 4,4''''-difluoro-3,3''''- bis(trifluoromethyl)-2'',3''-bis(3-(trifluoromethyl)phenyl)-1,1':4',1'':4'',1''':4''',1''''-quinquephenyl with 2'',3''',5'',6''-tetraphenyl-[1,1':4',1'': 4'',1''':4''',1''''-quinquephenyl]-4,4''''-diol and post-sulfonated was through chlorosulfonic acid to given sulfonated polymers (SFC3-X) possessing ion exchange capacities ranging from 1.93, 1.91 and 2.53 mmol/g. ¹H NMR and FT-IR spectroscopy were applied to confirm the structure and composition of sulfonated polymers. The membranes exhibited considerably dimension stability (10-27.8% in length change; 24-56.5% in thickness change) and excellent oxidative stability (weight remain higher than 97%). The mechanical properties of membranes demonstrated good tensile strength on account of the high rigidity multi-phenylated backbone. Young's modulus were ranged 0.65-0.77GPa which is much larger than that of Nafion 211 (0.10GPa). Proton conductivities of membranes ranged from 130 to 240 mS/cm at 80 °C under fully humidified which were comparable or higher than that of Nafion 211 (150 mS/cm). The morphology of membranes was investigated by transmission electron microscopy which demonstrated a clear hydrophilic/hydrophobic phase separation with spherical ionic clusters in the size range of 5-20 nm. The SFC3-1.97 single fuel cell performance demonstrates the maximum power density at 1.08W/cm², and Nafion 211 was 1.24W/cm² as a reference in this work. The result indicated that SFC3-X are good candidates for proton exchange membranes in fuel cell applications. Fuel cell of other membranes is under testing. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=fuel%20cells" title="fuel cells">fuel cells</a>, <a href="https://publications.waset.org/abstracts/search?q=polyelectrolyte" title=" polyelectrolyte"> polyelectrolyte</a>, <a href="https://publications.waset.org/abstracts/search?q=proton%20exchange%20membrane" title=" proton exchange membrane"> proton exchange membrane</a>, <a href="https://publications.waset.org/abstracts/search?q=sulfonated%20polymers" title=" sulfonated polymers"> sulfonated polymers</a> </p> <a href="https://publications.waset.org/abstracts/49002/synthesis-and-characterization-of-sulfonated-aromatic-hydrocarbon-polymers-containing-trifluoromethylphenyl-side-chain-for-proton-exchange-membrane-fuel-cell" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/49002.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">453</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1021</span> Preparation of hydrophobic silica membranes supported on alumina hollow fibers for pervaporation applications</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ami%20Okabe">Ami Okabe</a>, <a href="https://publications.waset.org/abstracts/search?q=Daisuke%20Gondo"> Daisuke Gondo</a>, <a href="https://publications.waset.org/abstracts/search?q=Akira%20Ogawa"> Akira Ogawa</a>, <a href="https://publications.waset.org/abstracts/search?q=Yasuhisa%20Hasegawa"> Yasuhisa Hasegawa</a>, <a href="https://publications.waset.org/abstracts/search?q=Koichi%20Sato"> Koichi Sato</a>, <a href="https://publications.waset.org/abstracts/search?q=Sadao%20Araki"> Sadao Araki</a>, <a href="https://publications.waset.org/abstracts/search?q=Hideki%20Yamamoto"> Hideki Yamamoto</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Membrane separation draws attention as the energy-saving technology. Pervaporation (PV) uses hydrophobic ceramic membranes to separate organic compounds from industrial wastewaters. PV makes it possible to separate organic compounds from azeotropic mixtures and from aqueous solutions. For the PV separation of low concentrations of organics from aqueous solutions, hydrophobic ceramic membranes are expected to have high separation performance compared with that of conventional hydrophilic membranes. Membrane separation performance is evaluated based on the pervaporation separation index (PSI), which depends on both the separation factor and the permeate flux. Ingenuity is required to increase the PSI such that the permeate flux increases without reducing the separation factor or to increase the separation factor without reducing the flux. A thin separation layer without defects and pinholes is required. In addition, it is known that the flux can be increased without reducing the separation factor by reducing the diffusion resistance of the membrane support. In a previous study, we prepared hydrophobic silica membranes by a molecular templating sol−gel method using cetyltrimethylammonium bromide (CTAB) to form pores suitable for permitting the passage of organic compounds through the membrane. We separated low-concentration organics from aqueous solutions by PV using these membranes. In the present study, hydrophobic silica membranes were prepared on a porous alumina hollow fiber support that is thinner than the previously used alumina support. Ethyl acetate (EA) is used in large industrial quantities, so it was selected as the organic substance to be separated. Hydrophobic silica membranes were prepared by dip-coating porous alumina supports with a -alumina interlayer into a silica sol containing CTAB and vinyltrimethoxysilane (VTMS) as the silica precursor. Membrane thickness increases with the lifting speed of the sol in the dip-coating process. Different thicknesses of the γ-alumina layer were prepared by dip-coating the support into a boehmite sol at different lifting speeds (0.5, 1, 3, and 5 mm s-1). Silica layers were subsequently formed by dip-coating using an immersion time of 60 s and lifting speed of 1 mm s-1. PV measurements of the EA (5 wt.%)/water system were carried out using VTMS hydrophobic silica membranes prepared on -alumina layers of different thicknesses. Water and EA flux showed substantially constant value despite of the change of the lifting speed to form the γ-alumina interlayer. All prepared hydrophobic silica membranes showed the higher PSI compared with the hydrophobic membranes using the previous alumina support of hollow fiber. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=membrane%20separation" title="membrane separation">membrane separation</a>, <a href="https://publications.waset.org/abstracts/search?q=pervaporation" title=" pervaporation"> pervaporation</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrophobic" title=" hydrophobic"> hydrophobic</a>, <a href="https://publications.waset.org/abstracts/search?q=silica" title=" silica"> silica</a> </p> <a href="https://publications.waset.org/abstracts/35530/preparation-of-hydrophobic-silica-membranes-supported-on-alumina-hollow-fibers-for-pervaporation-applications" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/35530.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">404</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1020</span> Culture of Primary Cortical Neurons on Hydrophobic Nanofibers Induces the Formation of Organoid-Like Structures</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nick%20Weir">Nick Weir</a>, <a href="https://publications.waset.org/abstracts/search?q=Robert%20Stevens"> Robert Stevens</a>, <a href="https://publications.waset.org/abstracts/search?q=Alan%20Hargreaves"> Alan Hargreaves</a>, <a href="https://publications.waset.org/abstracts/search?q=Martin%20McGinnity"> Martin McGinnity</a>, <a href="https://publications.waset.org/abstracts/search?q=Chris%20Tinsley"> Chris Tinsley</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Hydrophobic materials have previously demonstrated the ability to elevate cell-cell interactions and promote the formation of neural networks whilst aligned nanofibers demonstrate the ability to induce extensive neurite outgrowth in an aligned manner. Hydrophobic materials typically elicit an immune response upon implantation and thus materials used for implantation are typically hydrophilic. Poly-L-lactic acid (PLLA) is a hydrophobic, non-immunogenic, FDA approved material that can be electrospun to form aligned nanofibers. Primary rat cortical neurons cultured for 10 days on aligned PLLA nanofibers formed 3D cell clusters, approximately 800 microns in diameter. Neurites that extended from these clusters were highly aligned due to the alignment of the nanofibers they were cultured upon and fasciculation was also evident. Plasma treatment of the PLLA nanofibers prior to seeding of cells significantly reduced the hydrophobicity and abolished the cluster formation and neurite fasciculation, whilst reducing the extent and directionality of neurite outgrowth; it is proposed that hydrophobicity induces the changes to cellular behaviors. Aligned PLLA nanofibers induced the formation of a structure that mimics the grey-white matter compartmentalization that is observed in vivo and thus represents a step forward in generating organoids or biomaterial-based implants. Upon implantation into the brain, the biomaterial architectures described here may provide a useful platform for both brain repair and brain remodeling initiatives. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=hydrophobicity" title="hydrophobicity">hydrophobicity</a>, <a href="https://publications.waset.org/abstracts/search?q=nanofibers" title=" nanofibers"> nanofibers</a>, <a href="https://publications.waset.org/abstracts/search?q=neurite%20fasciculation" title=" neurite fasciculation"> neurite fasciculation</a>, <a href="https://publications.waset.org/abstracts/search?q=neurite%20outgrowth" title=" neurite outgrowth"> neurite outgrowth</a>, <a href="https://publications.waset.org/abstracts/search?q=PLLA" title=" PLLA"> PLLA</a> </p> <a href="https://publications.waset.org/abstracts/92274/culture-of-primary-cortical-neurons-on-hydrophobic-nanofibers-induces-the-formation-of-organoid-like-structures" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/92274.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">160</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1019</span> Thermodynamics of Water Condensation on an Aqueous Organic-Coated Aerosol Aging via Chemical Mechanism</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Yuri%20S.%20Djikaev">Yuri S. Djikaev</a> </p> <p class="card-text"><strong>Abstract:</strong></p> A large subset of aqueous aerosols can be initially (immediately upon formation) coated with various organic amphiphilic compounds whereof the hydrophilic moieties are attached to the aqueous aerosol core while the hydrophobic moieties are exposed to the air thus forming a hydrophobic coating thereupon. We study the thermodynamics of water condensation on such an aerosol whereof the hydrophobic organic coating is being concomitantly processed by chemical reactions with atmospheric reactive species. Such processing (chemical aging) enables the initially inert aerosol to serve as a nucleating center for water condensation. The most probable pathway of such aging involves atmospheric hydroxyl radicals that abstract hydrogen atoms from hydrophobic moieties of surface organics (first step), the resulting radicals being quickly oxidized by ubiquitous atmospheric oxygen molecules to produce surface-bound peroxyl radicals (second step). Taking these two reactions into account, we derive an expression for the free energy of formation of an aqueous droplet on an organic-coated aerosol. The model is illustrated by numerical calculations. The results suggest that the formation of aqueous cloud droplets on such aerosols is most likely to occur via Kohler activation rather than via nucleation. The model allows one to determine the threshold parameters necessary for their Kohler activation. Numerical results also corroborate previous suggestions that one can neglect some details of aerosol chemical composition in investigating aerosol effects on climate. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=aqueous%20aerosols" title="aqueous aerosols">aqueous aerosols</a>, <a href="https://publications.waset.org/abstracts/search?q=organic%20coating" title=" organic coating"> organic coating</a>, <a href="https://publications.waset.org/abstracts/search?q=chemical%20aging" title=" chemical aging"> chemical aging</a>, <a href="https://publications.waset.org/abstracts/search?q=cloud%20condensation%20nuclei" title=" cloud condensation nuclei"> cloud condensation nuclei</a>, <a href="https://publications.waset.org/abstracts/search?q=Kohler%20activation" title=" Kohler activation"> Kohler activation</a>, <a href="https://publications.waset.org/abstracts/search?q=cloud%20droplets" title=" cloud droplets"> cloud droplets</a> </p> <a href="https://publications.waset.org/abstracts/43796/thermodynamics-of-water-condensation-on-an-aqueous-organic-coated-aerosol-aging-via-chemical-mechanism" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/43796.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">395</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1018</span> Increase of the Nanofiber Degradation Rate Using PCL-PEO and PCL-PVP as a Shell in the Electrospun Core-Shell Nanofibers Using the Needleless Blades</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Matej%20Buzgo">Matej Buzgo</a>, <a href="https://publications.waset.org/abstracts/search?q=Erico%20Himawan"> Erico Himawan</a>, <a href="https://publications.waset.org/abstracts/search?q=Ksenija%20Ja%C5%A1Ina"> Ksenija JašIna</a>, <a href="https://publications.waset.org/abstracts/search?q=Aiva%20Simaite"> Aiva Simaite</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Electrospinning is a versatile and efficient technology for producing nanofibers for biomedical applications. One of the most common polymers used for the preparation of nanofibers for regenerative medicine and drug delivery applications is polycaprolactone (PCL). PCL is a biocompatible and bioabsorbable material that can be used to stimulate the regeneration of various tissues. It is also a common material used for the development of drug delivery systems by blending the polymer with small active molecules. However, for many drug delivery applications, e.g. cancer immunotherapy, PCL biodegradation rate that may exceed 9 months is too long, and faster nanofiber dissolution is needed. In this paper, we investigate the dissolution and small molecule release rates of PCL blends with two hydrophilic polymers: polyethylene oxide (PEO) or polyvinylpyrrolidone (PVP). We show that adding hydrophilic polymer to the PCL reduces the water contact angle, increases the dissolution rate, and strengthens the interactions between the hydrophilic drug and polymer matrix that further sustain its release. Finally using this method, we were also able to increase the nanofiber degradation rate when PCL-PEO and PCL-PVP were used as a shell in the electrospun core-shell nanofibers and spread up the release of active proteins from their core. Electrospinning can be used for the preparation of the core-shell nanofibers, where active ingredients are encapsulated in the core and their release rate is regulated by the shell. However, such fibers are usually prepared by coaxial electrospinning that is an extremely low-throughput technique. An alternative is emulsion electrospinning that could be upscaled using needleless blades. In this work, we investigate the possibility of using emulsion electrospinning for encapsulation and sustained release of the growth factors for the development of the organotypic skin models. The core-shell nanofibers were prepared using the optimized formulation and the release rate of proteins from the fibers was investigated for 2 weeks – typical cell culture conditions. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=electrospinning" title="electrospinning">electrospinning</a>, <a href="https://publications.waset.org/abstracts/search?q=polycaprolactone%20%28PCL%29" title=" polycaprolactone (PCL)"> polycaprolactone (PCL)</a>, <a href="https://publications.waset.org/abstracts/search?q=polyethylene%20oxide%20%28PEO%29" title=" polyethylene oxide (PEO)"> polyethylene oxide (PEO)</a>, <a href="https://publications.waset.org/abstracts/search?q=polyvinylpyrrolidone%20%28PVP%29" title=" polyvinylpyrrolidone (PVP)"> polyvinylpyrrolidone (PVP)</a> </p> <a href="https://publications.waset.org/abstracts/138097/increase-of-the-nanofiber-degradation-rate-using-pcl-peo-and-pcl-pvp-as-a-shell-in-the-electrospun-core-shell-nanofibers-using-the-needleless-blades" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/138097.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">273</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1017</span> Developing a Novel Fluorescent Sensor for Detecting Analytes in an Aqueous Medium</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Varshith%20Kotagiri">Varshith Kotagiri</a>, <a href="https://publications.waset.org/abstracts/search?q=Lei%20Li"> Lei Li</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Fluorescent sensors are organic fluorophores that detect specific analytes with quantitative fluorescence intensity changes. They have offered impressive benefits compared with instrumental techniques, such as low cost, high selectivity, and rapid responses. One issue that limits the fluorescent sensors for further application is their poor solubility in the aqueous medium, where most targeted analytes, including metal ions, inorganic anions, and neutral biomolecules, are readily soluble. When fluorescent sensors are utilized to detect these analytes, a heterogeneous phase is formed. In most cases, an extra water-miscible organic solvent is needed as an additive to facilitate the sensing process, which complicates the measurement operations and produces more organic waste. We aim to resolve this issue by skillful molecular design to introduce a hydrophilic side chain to the fluorescent sensor, increasing its water solubility and facilitating its sensing process to analytes, like various protons, fluoride ions, and copper ions, in an aqueous medium. Simultaneously, its sensitivity and selectivity will be retained. This work will simplify the sensing operations and reduce the amount of organic waste produced during the measurement. This strategy will additionally be of broad interest to the chemistry community, as it introduces the idea of modifying the molecular structure to apply an initial hydrophobic compound under hydrophilic conditions in a feasible way. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=organic%20fluorescent%20sensor" title="organic fluorescent sensor">organic fluorescent sensor</a>, <a href="https://publications.waset.org/abstracts/search?q=analytes" title=" analytes"> analytes</a>, <a href="https://publications.waset.org/abstracts/search?q=sensing" title=" sensing"> sensing</a>, <a href="https://publications.waset.org/abstracts/search?q=aqueous%20medium" title=" aqueous medium"> aqueous medium</a>, <a href="https://publications.waset.org/abstracts/search?q=phenanthroimidazole" title=" phenanthroimidazole"> phenanthroimidazole</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrophilic%20side%20chain" title=" hydrophilic side chain"> hydrophilic side chain</a> </p> <a href="https://publications.waset.org/abstracts/195039/developing-a-novel-fluorescent-sensor-for-detecting-analytes-in-an-aqueous-medium" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/195039.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">3</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1016</span> Controlled Release of Curcumin from a Thermoresponsive Polypeptide Hydrogel for Anti-Tumor Therapy</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Chieh-Nan%20Chen">Chieh-Nan Chen</a>, <a href="https://publications.waset.org/abstracts/search?q=Ji-Yu%20Lin"> Ji-Yu Lin</a>, <a href="https://publications.waset.org/abstracts/search?q=I-Ming%20Chu"> I-Ming Chu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Polypeptide thermosensitive hydrogel is an excellent candidate as a smart device to deliver drugs and cells due to its remarkable biocompatibility, low gelation concentration, and respond to temperature stimuli, it can be easily injected as a polymer solution into the patient’s body where it undergoes gelation due to an elevation in temperature. Poly (ethylene glycol) monomethyl ether-poly (ethyl-l-glutamate) (mPEG-PELG) contains a hydrophobic side chain –C2H5 which is useful in encapsulating and stabilizing hydrophobic drugs. In this study, we plan to focus on the hydrophobic anti-carcinogenic and anti-inflammatory drug curcumin, which due its insolubility in water, requires a proper carrier for delivery into the body. Our main concept is to use mPEG-PELG to stabilize curcumin, inject the curcumin-loaded hydrogel into the tumor site, and allow the enzymatically-sensitive hydrogel to be degraded by bodily fluids and release the drug. The polymers of interest have been successfully synthesized and characterized by 1H-NMR, FT-IR, SEM, and CMC. Curcumin loading content and drug release were assayed using HPLC. Preliminary results show that these materials have potential as a delivery vehicle for poorly soluble drugs. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=curcumin" title="curcumin">curcumin</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20release" title=" drug release"> drug release</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrogel" title=" hydrogel"> hydrogel</a>, <a href="https://publications.waset.org/abstracts/search?q=polypeptide%20material" title=" polypeptide material"> polypeptide material</a> </p> <a href="https://publications.waset.org/abstracts/46020/controlled-release-of-curcumin-from-a-thermoresponsive-polypeptide-hydrogel-for-anti-tumor-therapy" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/46020.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> 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