<?xml version="1.0" encoding="UTF-8"?> <article key="pdf/5089" mdate="2011-12-22 00:00:00"> <author>Nguyen Anh Dzung and Nguyen Thi Ngoc H脿 and Dang Thi Hong Van and Nguyen Thi Lan Phuong and Nguyen Thi Nhu Quynh and Dinh Minh Hiep and Le Van Hiep</author> <title>Chitosan Nanoparticle as a Novel Delivery System for AH1n1 Influenza Vaccine Safe Property and Immunogenicity in Mice</title> <pages>915 - 922</pages> <year>2011</year> <volume>5</volume> <number>12</number> <journal>International Journal of Biotechnology and Bioengineering</journal> <ee>https://publications.waset.org/pdf/5089</ee> <url>https://publications.waset.org/vol/60</url> <publisher>World Academy of Science, Engineering and Technology</publisher> <abstract>The aims of this paper are to study the efficacy of chitosan nanoparticles in stimulating specific antibody against AH1N1 influenza antigen in mice. Chitosan nanoparticles (CSN) were characterized by TEM. The results showed that the average size of CSN was from 80nm to 106nm. The efficacy of AH1N1 influenza vaccine loaded on the surface of CSN showed that loading efficiency of AH1N1 influenza antigen on CSN was from 93.75 to 100. Safe property of the vaccine were tested. In 10 days post vaccination, group of CSN 30 kDa and 300 kDa loaded AH1N1 influenza antigen were the rate of immune response on mice to be 100 (99) higher than Al(OH)3 and other adjuvant. 100 mice in the experiment of all groups had immune response in 20 days post vaccination. The results also showed that HI titer of the group using CSN 300 kDa as an adjuvant increased significantly up to 3971 HIU, over threefold higher than the Al(OH)3 adjuvant, chitosan (CS), and one hundredfold than the AH1N1 antigen only. Stability of the vaccine formulation was investigated.</abstract> <index>Open Science Index 60, 2011</index> </article>