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src="https://attachments.academia-assets.com/107759909/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/109719138/Acute_Toxicity_and_Antipyretic_Activities_of_a_Methanolic_Extract_of_and_lt_i_and_gt_Alchornea_cordifolia_and_lt_i_and_gt_Leaves">Acute Toxicity and Antipyretic Activities of a Methanolic Extract of &lt;i&gt;Alchornea cordifolia&lt;/i&gt; Leaves</a></div><div class="wp-workCard_item"><span>Pharmacology &amp; Pharmacy</span><span>, 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Alchornea cordifolia (Euphorbiaceae) is a very prized plant among traditional healers in Africa. ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Alchornea cordifolia (Euphorbiaceae) is a very prized plant among traditional healers in Africa. Its leaves are used for its antipyretic properties in traditional areas. The aim of our study is to determine the acute toxicity and the antipyretic activity of a methanolic extract of Alchornea cordifolia leaves. Acute toxicity was assessed by measuring mortality, changes in body weight, spontaneous movements, and normal rectal temperature in mice. Antipyretic activity was evaluated by brewer's yeast-induced hyperpyrexia in rats according to Teotino method (1963). The antipyretic effect of methanolicextract of Alchornea cordifolia leaves was compared with paracetamol (100 mg/kg bw) orally. Groups of mice treated with doses of 6500; 3250; 1625 and 812.5mg/kg of the extract did not show any mortality, nor significant alteration of body weight, nor alteration of spontaneous movements. However, incomplete reversed dose-dependent hypothermic activity was observed with doses of 50.78; 101.56; 203.12; 406.25; and 812.5 mg/kg p.o. of the extract, showing acute toxicity of this plant. In the antipyretic assay, the extract with doses of 50.78; 101.56; 203.12; 406.25; and 812.5 mg/kg p.o. exhibited a significant dose-dependent antipyretic activity similar to paracetamol (100 mg/kg bw) in rats. Thus Alchornea cordifolia may inhibit prostaglandins-biosynthesis from hypothalamus. Our results support claims on its traditional uses in management of fever. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="109719137"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/109719137/Oxygen_species_scavenger_activities_and_phenolic_contents_of_four_West_African_plants"><img alt="Research paper thumbnail of Oxygen species scavenger activities and phenolic contents of four West African plants" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/109719137/Oxygen_species_scavenger_activities_and_phenolic_contents_of_four_West_African_plants">Oxygen species scavenger activities and phenolic contents of four West African plants</a></div><div class="wp-workCard_item"><span>Food Chemistry</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In West Africa, Alchornea cordifolia, Baphia nitida, Cassia occidentalis and Boerhavia diffusa le...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In West Africa, Alchornea cordifolia, Baphia nitida, Cassia occidentalis and Boerhavia diffusa leaves are used in food and drinks, as well as in traditional medicine, to treat rheumatic ailments which incur oxidative stress. First, these plants were evaluated for their antioxidant properties through a scavenger effect on reactive oxygen species (ROS), such as hydrogen peroxide and hypochlorous acid. All of</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="109719137"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="109719137"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 109719137; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=109719137]").text(description); $(".js-view-count[data-work-id=109719137]").attr('title', description).tooltip(); 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</script> <div class="js-work-strip profile--work_container" data-work-id="109719121"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/109719121/Effects_ofAlchornea_cordifoliaon_elastase_and_superoxide_anion_produced_by_human_neutrophils"><img alt="Research paper thumbnail of Effects ofAlchornea cordifoliaon elastase and superoxide anion produced by human neutrophils" class="work-thumbnail" src="https://attachments.academia-assets.com/108703509/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/109719121/Effects_ofAlchornea_cordifoliaon_elastase_and_superoxide_anion_produced_by_human_neutrophils">Effects ofAlchornea cordifoliaon elastase and superoxide anion produced by human neutrophils</a></div><div class="wp-workCard_item"><span>Pharmaceutical Biology</span><span>, 2009</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f966932371f569b7e201fcff369d976e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108703509,"asset_id":109719121,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108703509/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="109719121"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="109719121"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 109719121; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=109719121]").text(description); $(".js-view-count[data-work-id=109719121]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 109719121; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='109719121']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "f966932371f569b7e201fcff369d976e" } } $('.js-work-strip[data-work-id=109719121]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":109719121,"title":"Effects ofAlchornea cordifoliaon elastase and superoxide anion produced by human neutrophils","internal_url":"https://www.academia.edu/109719121/Effects_ofAlchornea_cordifoliaon_elastase_and_superoxide_anion_produced_by_human_neutrophils","owner_id":151130319,"coauthors_can_edit":true,"owner":{"id":151130319,"first_name":"Geneviève","middle_initials":null,"last_name":"N'guessan-Irié","page_name":"GenevièveNguessanIrié","domain_name":"independent","created_at":"2020-03-25T09:44:04.654-07:00","display_name":"Geneviève N'guessan-Irié","url":"https://independent.academia.edu/Genevi%C3%A8veNguessanIri%C3%A9"},"attachments":[{"id":108703509,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108703509/thumbnails/1.jpg","file_name":"13880200903051609.pdf","download_url":"https://www.academia.edu/attachments/108703509/download_file","bulk_download_file_name":"Effects_ofAlchornea_cordifoliaon_elastas.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108703509/13880200903051609-libre.pdf?1702257716=\u0026response-content-disposition=attachment%3B+filename%3DEffects_ofAlchornea_cordifoliaon_elastas.pdf\u0026Expires=1739793909\u0026Signature=hRMFWVL1WkLKJXNKIjk3KD~CHEG0RLOaQCaaneExhjgIJIKhSkrpigARGw74Uw9Rghzo8DysJ-cOrmE08M-V~M~11ih1MtBz3fnbaJDLqO8ZVmjUfRFQzOGb-1qSD6laBUTBKIZb-5mn8ojSvepWCnLSZaJHV-zvJvZYiuNivAV7hJ6CicPllrQthghW5qek5mw0dMT9cBLs1qVSeFrFoHbFIFp1aIiS5P~b~liV4eaFff2qy7~sYDcUo3zztmSucSamDrdnowv-3LSxDuRa0jeGhvWFE8fDUnQ6AKEa1pKd-ADXJR~l-5TWAQ-KY3u~ZmOUyFAER~DR8zwpqicoWw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="74627915"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/74627915/Pharmacological_management_of_adverse_events_during_treatment_of_chronic_viral_hepatitis_in_three_Ivorian_university_hospitals"><img alt="Research paper thumbnail of Pharmacological management of adverse events during treatment of chronic viral hepatitis in three Ivorian university hospitals" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/74627915/Pharmacological_management_of_adverse_events_during_treatment_of_chronic_viral_hepatitis_in_three_Ivorian_university_hospitals">Pharmacological management of adverse events during treatment of chronic viral hepatitis in three Ivorian university hospitals</a></div><div class="wp-workCard_item"><span>International journal of clinical pharmacology and therapeutics</span><span>, Feb 26, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This work aims to evaluate the therapeutic survey of adverse events during antiviral treatment of...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This work aims to evaluate the therapeutic survey of adverse events during antiviral treatment of hepatitis in the three major University Hospitals in Abidjan. A retrospective cross-sectional descriptive study of 203 patients from August 1, 2015, to July 31, 2018, enumerated adverse events during antiviral treatments, drugs used for their management, and their clinical or biological impact. The following was seen: hematological disorders during treatment with pegylated interferon α-2a (88.61%) and ribavirin (77.55%), pain syndrome when using pegylated interferon α-2a (90.5%), and digestive disorders while taking sofosbuvir (60.71%) and daclatasvir (66.67%). Hematological disorders were managed with filgrastim for neutropenia and oral iron or blood transfusion for anemia and/or thrombocytopenia. Pain syndrome was treated with paracetamol. As for digestive disorders, they were most often managed with activated charcoal. Correction of the adverse events was made either using causal tre...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="74627915"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="74627915"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 74627915; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=74627915]").text(description); $(".js-view-count[data-work-id=74627915]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 74627915; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='74627915']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=74627915]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":74627915,"title":"Pharmacological management of adverse events during treatment of chronic viral hepatitis in three Ivorian university hospitals","internal_url":"https://www.academia.edu/74627915/Pharmacological_management_of_adverse_events_during_treatment_of_chronic_viral_hepatitis_in_three_Ivorian_university_hospitals","owner_id":151130319,"coauthors_can_edit":true,"owner":{"id":151130319,"first_name":"Geneviève","middle_initials":null,"last_name":"N'guessan-Irié","page_name":"GenevièveNguessanIrié","domain_name":"independent","created_at":"2020-03-25T09:44:04.654-07:00","display_name":"Geneviève N'guessan-Irié","url":"https://independent.academia.edu/Genevi%C3%A8veNguessanIri%C3%A9"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="74627914"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/74627914/Beta_lactams_and_Aminoglycosides_in_Neonates_at"><img alt="Research paper thumbnail of Beta-lactams and Aminoglycosides in Neonates at" class="work-thumbnail" src="https://attachments.academia-assets.com/82712701/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/74627914/Beta_lactams_and_Aminoglycosides_in_Neonates_at">Beta-lactams and Aminoglycosides in Neonates at</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Aim: In Ivory Coast, neonatal infections are very frequent. However the antibacterial therapy of ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Aim: In Ivory Coast, neonatal infections are very frequent. However the antibacterial therapy of these diseases is not still the object of a national consensus. Then it seems important to make the current situation of antibacterial therapy in neonates in reference Hospitals like the University Hospital of Cocody. The aim of this study was to analyze the practice of antibacterial care in neonatal infections there with regard to international recommendations, if need be, to make propositions for improvement. Methods: Two hundred and fourteen neonates hospitalized for infection except parasitic or viral disorders were recruited for seven-month transversal study. Hospital practices were observed and detailed antibacterial therapy was noted. Results: Antibacterial therapy was dominated by double-antibacterial therapy (98.13%). This concerned in first intention Amoxicillin 100 Mg/Kg twice a day or Ceftriaxone 100 Mg/Kg once a day in direct intravenous injection + Netilmicin or Gentamycin ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7834a02f7f94984b917b6f34c3ae16ea" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":82712701,"asset_id":74627914,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/82712701/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="74627914"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="74627914"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 74627914; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="74627913"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/74627913/Bilan_dune_d%C3%A9cennie_dalertes_m%C3%A9dicamenteuses_en_C%C3%B4te_dIvoire_de_2001_%C3%A0_2010"><img alt="Research paper thumbnail of Bilan d'une décennie d'alertes médicamenteuses en Côte d'Ivoire de 2001 à 2010" class="work-thumbnail" src="https://attachments.academia-assets.com/83502769/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/74627913/Bilan_dune_d%C3%A9cennie_dalertes_m%C3%A9dicamenteuses_en_C%C3%B4te_dIvoire_de_2001_%C3%A0_2010">Bilan d'une décennie d'alertes médicamenteuses en Côte d'Ivoire de 2001 à 2010</a></div><div class="wp-workCard_item"><span>The´rapie (Paris)</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">-Objectif. Ce travail vise un suivi plus efficient de la sécurité des médicaments à usage humain ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">-Objectif. Ce travail vise un suivi plus efficient de la sécurité des médicaments à usage humain sur le marché ivoirien. Méthode. La direction de la pharmacie et du médicament (DPM) a répertorié toutes les alertes médicamenteuses de 2001 à 2010. Résultats. Il ressort 237 alertes médicamenteuses dont 145 arrêts de commercialisation, 55 retraits de lots, 33 notes d'information et 4 levées de suspension de médicaments. Ces alertes proviennent majoritairement des laboratoires pharmaceutiques (49 %) et de ANSM (ex-Afssaps) [43 %]. Elles concernent principalement les médicaments à visée antiinfectieuse (22 %) et pneumologique (18 %) et leurs motivations sont tant industrielles avec majoritairement des raisons commerciales (27 %) que de pharmacovigilance dominées par les rapports bénéfice/risque défavorables. Conclusion. Ces résultats constituent une base de données importante pour la surveillance du marché des médicaments sur le territoire ivoirien et une motivation supplémentaire pour accélérer la mise en place d'un véritable centre national de pharmacovigilance.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2f85a84bde7dbb6789d9871fed3ef0d8" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":83502769,"asset_id":74627913,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/83502769/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="74627913"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="74627913"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 74627913; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="74627912"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/74627912/Isolation_and_Spasmolytic_Evaluation_of_New_Alkaloids_from_i_Dichrostachys_cinerea_i_L_Wight_et_Arn_Fabaceae_"><img alt="Research paper thumbnail of Isolation and Spasmolytic Evaluation of New Alkaloids from <i>Dichrostachys cinerea</i> (L.) Wight et Arn. (Fabaceae)" class="work-thumbnail" src="https://attachments.academia-assets.com/82712699/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/74627912/Isolation_and_Spasmolytic_Evaluation_of_New_Alkaloids_from_i_Dichrostachys_cinerea_i_L_Wight_et_Arn_Fabaceae_">Isolation and Spasmolytic Evaluation of New Alkaloids from <i>Dichrostachys cinerea</i> (L.) Wight et Arn. (Fabaceae)</a></div><div class="wp-workCard_item"><span>Pharmacology and Pharmacy</span><span>, 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Dichrostachys cinerea (L.) Wight et Arn. (Fabaceae) root bark is used in Ivorian Traditional Medi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Dichrostachys cinerea (L.) Wight et Arn. (Fabaceae) root bark is used in Ivorian Traditional Medicine to treat asthma, which is a respiratory disorder characterized by inflammation and the restriction of tracheal muscles obstructing the air circulation. The tracheal relaxant effect of a crude aqueous-alcoholic extract of the plant root bark was previously shown. For the present study, alkaloids were isolated from the same extract and investigated ex vivo in C57Bl/6j mice isolated trachea contracted with carbachol 1 µM, in comparison with a reference bronchodilatator, i.e. salbutamol. Two extraction procedures allowed isolating 2 Alkaloids that monodimensional and bi-dimensional nuclear magnetic resonance (NMR) and mass specters allowed identifying a pyrolidine structure type nucleus with a long bi-hydroxyled alkyl chain. Alkaloid 1, carrier of a sugar, is a glycoside of Alkaloid 2. Both alkaloids induced similar spasmolytic effects, but Alkaloid 1 was more effective than Alkaloid 2 at 9 × 10 −6 M (p ˂ 0.01), 3 × 10 −5 M, and 9 × 10 −5 M (p ˂ 0.001). Salbutamol induced its spasmolytic effect in a different way, and its maximal effect E max (less than 30%) was obtained at 9 × 10 −6 M, while E max of both alkaloids (100%) was obtained at 3 × 10 −4 M.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8a8c5e62e6b103fb43f462eefa8611fa" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":82712699,"asset_id":74627912,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/82712699/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="74627912"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="74627912"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 74627912; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=74627912]").text(description); $(".js-view-count[data-work-id=74627912]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 74627912; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='74627912']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8a8c5e62e6b103fb43f462eefa8611fa" } } $('.js-work-strip[data-work-id=74627912]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":74627912,"title":"Isolation and Spasmolytic Evaluation of New Alkaloids from \u003ci\u003eDichrostachys cinerea\u003c/i\u003e (L.) 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(Fabaceae)","internal_url":"https://www.academia.edu/74627912/Isolation_and_Spasmolytic_Evaluation_of_New_Alkaloids_from_i_Dichrostachys_cinerea_i_L_Wight_et_Arn_Fabaceae_","owner_id":151130319,"coauthors_can_edit":true,"owner":{"id":151130319,"first_name":"Geneviève","middle_initials":null,"last_name":"N'guessan-Irié","page_name":"GenevièveNguessanIrié","domain_name":"independent","created_at":"2020-03-25T09:44:04.654-07:00","display_name":"Geneviève N'guessan-Irié","url":"https://independent.academia.edu/Genevi%C3%A8veNguessanIri%C3%A9"},"attachments":[{"id":82712699,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/82712699/thumbnails/1.jpg","file_name":"PaperDownload.pdf","download_url":"https://www.academia.edu/attachments/82712699/download_file","bulk_download_file_name":"Isolation_and_Spasmolytic_Evaluation_of.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/82712699/PaperDownload-libre.pdf?1648310425=\u0026response-content-disposition=attachment%3B+filename%3DIsolation_and_Spasmolytic_Evaluation_of.pdf\u0026Expires=1739793910\u0026Signature=beitiXwEwSrOpZh-rY0U6bSNlZJPo2arQYWXSJtcwYyEIkMC2IyVvKHoZdc-p6V54nDt5QdnRE6tThRmiQMcr-vohx-N~T6z0f6Q6pOJ8EjZP25odCmQo-EsWeCH7WJBuCZmkr9KpdswWeSOJuhQRxaq7BlysE-KszYrgrl54NbNvzcUyRREjzIMawzmC6yQW5FbANofKWonHH6b5QA4JGtCJMSwCEM6ZecFPhx0tVxk-HpRXQmvj8f78ZWxDK0vn5RNw6R8h3qFTj24kU0AiFAhEB4vLOH6RnDUxQji1rlrKME0cWSm6rfgLUYYCm00r-gUyzfhNI84NEpx1gLIkQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":82712700,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/82712700/thumbnails/1.jpg","file_name":"PaperDownload.pdf","download_url":"https://www.academia.edu/attachments/82712700/download_file","bulk_download_file_name":"Isolation_and_Spasmolytic_Evaluation_of.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/82712700/PaperDownload-libre.pdf?1648310424=\u0026response-content-disposition=attachment%3B+filename%3DIsolation_and_Spasmolytic_Evaluation_of.pdf\u0026Expires=1739793910\u0026Signature=VY-JXuNCc9WjtPGrUg03UWfav6FjPwUDztewFnGmFMmQIfCC64EtjiA7v3iQ6akXHuPj1wTJXkpttRCBiCEeiSQPRG75MDAjMH8VBbq8Sg3HlNOWLY3XnvaxN9AmrO8TJgLR0kPq6uCcr~U2M5CEa-HCDsqJDV-Bwom9FF0K-0finBamIGbfSixwnvNx6jlX0JYcE6iRaxMHFbi7VXnVs3R4TT0Hlz84F4wO01wFXbKMnbT8yYhVceuLKqghcdgeACUE8poPuu1azAqF6N7dARJQNkrVxK6HIqBLguTJ81PETwBUmzXfuroaL8gLvsDnfl9pGFEMVVW3jdX8m6jMmw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="74627911"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/74627911/Review_of_Experimental_Pharmacological_Studies_of_Plants_Used_for_Asthma_Management_in_Africa"><img alt="Research paper thumbnail of Review of Experimental Pharmacological Studies of Plants Used for Asthma Management in Africa" class="work-thumbnail" src="https://attachments.academia-assets.com/82712737/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/74627911/Review_of_Experimental_Pharmacological_Studies_of_Plants_Used_for_Asthma_Management_in_Africa">Review of Experimental Pharmacological Studies of Plants Used for Asthma Management in Africa</a></div><div class="wp-workCard_item"><span>International Journal of Pharmaceutics & Pharmacology</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objectives: The aim was to contribute to the promotion of medicinal plants used in Africa for man...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objectives: The aim was to contribute to the promotion of medicinal plants used in Africa for management of asthma by analyzing their experimental pharmacological evaluation data. Methods: We carried out a systematic review of the literature based on the following research equations in English and in French: « médecine traditionnelle africaine » ET « asthma » ; « African traditional medicine » AND « asthma » or « Medicine African traditional » AND « asthma » ; « plantes médicinales » ET « asthma » ET « antispasmodique » ; «medicinal plants » AND « asthma » AND « anti-spasmodic » ; « plantes médicinales » ET « asthma » ET « anti-inflammatoire » ; «medicinal plants » AND « asthma » AND « anti-inflammatory ». Results: The study revealed 184 medicinal plants used in Africa for the treatment of asthma, 34 of which showed pharmacological properties in favor of their use. In animal experiments, 18 of these plants exerted a spasmolytic effect, 22 an anti-inflammatory effect and 6 both effec...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5822addd15ac533100e67dcb39c0c231" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":82712737,"asset_id":74627911,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/82712737/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="74627911"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="74627911"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 74627911; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=74627911]").text(description); $(".js-view-count[data-work-id=74627911]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 74627911; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='74627911']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="74627866"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/74627866/Hyperglycaemia_lowering_activity_and_hypoglycaemic_risk_assessment_of_Sarenta_an_Ivorian_traditional_herbal_remedy"><img alt="Research paper thumbnail of Hyperglycaemia lowering activity and hypoglycaemic risk assessment of Sarenta, an Ivorian traditional herbal remedy" class="work-thumbnail" src="https://attachments.academia-assets.com/82712710/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/74627866/Hyperglycaemia_lowering_activity_and_hypoglycaemic_risk_assessment_of_Sarenta_an_Ivorian_traditional_herbal_remedy">Hyperglycaemia lowering activity and hypoglycaemic risk assessment of Sarenta, an Ivorian traditional herbal remedy</a></div><div class="wp-workCard_item"><span>International Journal of Basic & Clinical Pharmacology</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Diabetes remains a major public health problem for which traditional medicine is a be...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Diabetes remains a major public health problem for which traditional medicine is a better therapeutic alternative for low-income populations, including African populations. The aim of this work was to evaluate the effect of Sarenta, an herbal preparation used in Ivorian traditional medicine as anti-diabetic, on hyperglycaemia and on basic glycaemia.Methods: Hyperglycaemia lowering activity was led in rats receiving glucose at 5 g/kg body weight by gavage after oral pre-treatment with either Sarenta at 125, 206 or 209.5 mg/kg b. wt., either glibenclamide at 10 mg/kg b. wt., or physiological saline solution. Hypoglycaemic risk was assessed by administering the same doses of Sarenta to native i.e. NaCl-treated rats. For both tests, blood glucose was measured before any substance was administered and then every hour for 4 hours.Results: After 4 hours, Sarenta at 206 mg/kg b. wt. and 209.5 mg/kg b. wt. significantly reduced the induced hyperglycaemia in rats by 33.87% and 37....</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9a65829d961db0fd8a640ab41e8753ce" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":82712710,"asset_id":74627866,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/82712710/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="74627866"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="74627866"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 74627866; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9a65829d961db0fd8a640ab41e8753ce" } } $('.js-work-strip[data-work-id=74627866]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":74627866,"title":"Hyperglycaemia lowering activity and hypoglycaemic risk assessment of Sarenta, an Ivorian traditional herbal remedy","internal_url":"https://www.academia.edu/74627866/Hyperglycaemia_lowering_activity_and_hypoglycaemic_risk_assessment_of_Sarenta_an_Ivorian_traditional_herbal_remedy","owner_id":151130319,"coauthors_can_edit":true,"owner":{"id":151130319,"first_name":"Geneviève","middle_initials":null,"last_name":"N'guessan-Irié","page_name":"GenevièveNguessanIrié","domain_name":"independent","created_at":"2020-03-25T09:44:04.654-07:00","display_name":"Geneviève N'guessan-Irié","url":"https://independent.academia.edu/Genevi%C3%A8veNguessanIri%C3%A9"},"attachments":[{"id":82712710,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/82712710/thumbnails/1.jpg","file_name":"2570.pdf","download_url":"https://www.academia.edu/attachments/82712710/download_file","bulk_download_file_name":"Hyperglycaemia_lowering_activity_and_hyp.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/82712710/2570-libre.pdf?1648310425=\u0026response-content-disposition=attachment%3B+filename%3DHyperglycaemia_lowering_activity_and_hyp.pdf\u0026Expires=1739793910\u0026Signature=cLzGo4DEhEpwu30G9GlcD-7nKlJSQP7-p9BvBP-89NV3PeNJ5lJXkrgtJD0xur14eK9WjFbmnqz2F2-Z259NSx28kO4fjCg5N6jh9O8jvRwio8OzEu8cXnSWFA6-jGu8FVLez7dYvKUOuB7T~ZlBuIjAX-ZFMotrAwmES0l2rb3TWWCs9xbmffmzpSofhUPWYga3kYqy1gzIWUq3Bh3InFvnycq~inHtQF6era5NAkRjn0rgrobBqDsUYVzLXZRb0gXYnblm9r5ATf3QFavRzXRm1TiEu03V~~0o9Bklk4Ige7n-zrpYb2Bsp7dCxyhWwZICdxk~I~1j2tBo~LqwHQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="66116475"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/66116475/_Summarizing_of_medicinal_alerts_in_Ivory_Coast_from_2001_till_2010_"><img alt="Research paper thumbnail of [Summarizing of medicinal alerts in Ivory Coast from 2001 till 2010]" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/66116475/_Summarizing_of_medicinal_alerts_in_Ivory_Coast_from_2001_till_2010_">[Summarizing of medicinal alerts in Ivory Coast from 2001 till 2010]</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">UNLABELLED STUDY&#39;S AIM: This study aims a more efficient follow-up of the safety of medicines...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">UNLABELLED STUDY&#39;S AIM: This study aims a more efficient follow-up of the safety of medicines with human usage on the Ivory Coast territory. METHOD The structure responsible for pharmacovigilance in Ivory Coast i.e. DPM listed the medicinal alerts from 2001 till 2010. RESULTS It emerges 237 medicinal alerts among which 145 stops of marketing, 55 withdrawals of lots, 33 information notes and 4 levying of suspension of medicines. These alerts result mainly from pharmaceutical companies (49%) and the French Drug Agency or ANSM (ex-Afssaps) (43%). They mainly concern drugs of infectious target (22%) and pneumology (18%) and their motivations are so much industrial with mainly commercial reasons (27%) as of pharmacovigilance dominated by unfavorable profit/risk connections. CONCLUSION These results constitute an important database for the survey of the medicines market in Ivory Coast and an additional motivation to accelerate the implementation of a real national center of pharmacovi...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="66116475"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="66116475"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 66116475; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=66116475]").text(description); $(".js-view-count[data-work-id=66116475]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 66116475; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='66116475']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=66116475]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":66116475,"title":"[Summarizing of medicinal alerts in Ivory Coast from 2001 till 2010]","internal_url":"https://www.academia.edu/66116475/_Summarizing_of_medicinal_alerts_in_Ivory_Coast_from_2001_till_2010_","owner_id":151130319,"coauthors_can_edit":true,"owner":{"id":151130319,"first_name":"Geneviève","middle_initials":null,"last_name":"N'guessan-Irié","page_name":"GenevièveNguessanIrié","domain_name":"independent","created_at":"2020-03-25T09:44:04.654-07:00","display_name":"Geneviève N'guessan-Irié","url":"https://independent.academia.edu/Genevi%C3%A8veNguessanIri%C3%A9"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="66116406"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/66116406/Pharmacotherapeutic_aspect_of_antibiotic_therapy_during_acute_community_acquired_pneumonia_in_adults_at_the_University_Hospital_of_Cocody_Abidjan_"><img alt="Research paper thumbnail of Pharmacotherapeutic aspect of antibiotic therapy during acute community-acquired pneumonia in adults at the University Hospital of Cocody (Abidjan)" class="work-thumbnail" src="https://attachments.academia-assets.com/77498996/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/66116406/Pharmacotherapeutic_aspect_of_antibiotic_therapy_during_acute_community_acquired_pneumonia_in_adults_at_the_University_Hospital_of_Cocody_Abidjan_">Pharmacotherapeutic aspect of antibiotic therapy during acute community-acquired pneumonia in adults at the University Hospital of Cocody (Abidjan)</a></div><div class="wp-workCard_item"><span>Int. Journal of Clinical Pharmacology and Therapeutics</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">OBJECTIVE Acute community-acquired pneumonia in Côte d&#39;Ivoire, mainly in the pneumology units...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">OBJECTIVE Acute community-acquired pneumonia in Côte d&#39;Ivoire, mainly in the pneumology units, is the second most common cause of hospitalization after tuberculosis. This study aimed to evaluate the compliance of antibiotic therapy during bacterial acute community-acquired pneumonia with international guidelines serving as frame of reference at the University Hospital of Cocody. MATERIALS AND METHODS We carried out a descriptive retrospective and analytic study on 62 hospitalized patients from December 1, 2008 to November 30, 2010 in the Pneumophtisiology department at the University Hospital of Cocody (Abidjan). The prescription of antibiotics was compared with the recommendations of the 15th consensus conference on anti-infectious therapy by the Société de Pathologie Infectieuse de Langue Francaise (SPILF) (French Speaking Society of Infectious Pathology) held in 2006. RESULTS The main antibiotics prescribed were amoxicillin-clavulanic acid (42.27%), netilmicin (34.5%) and ciprofloxacin (6%). The antibiotic therapy diagrams were dominated by an antibiotic bitherapy; the association of amoxicillin-clavulanic acid+netilmicin was observed in 80.64% of the prescriptions. An antibiotic monotherapy was reported in 14.52% of the prescriptions. Apyrexia at 72 hours was obtained with 64% of the patients with nonstop antibiotic treatment, 24% of them presented a lack of apyrexia, and 12% of them died. The lack of apyrexia at 72 hours treatment correlated with concomitant administration of cotrimoxazole with prophylactic doses among HIV positive patients. The level of the compliance with the SPILF recommendations is low (3.6%). CONCLUSION Thus, our results convey the necessity to draw up national recommendations because of the specific realities of countries with limited incomes.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="42dd841c13b6389a96f648cce79cf186" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":77498996,"asset_id":66116406,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/77498996/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="66116406"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="66116406"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 66116406; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="13462535" id="papers"><div class="js-work-strip profile--work_container" data-work-id="109719138"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/109719138/Acute_Toxicity_and_Antipyretic_Activities_of_a_Methanolic_Extract_of_and_lt_i_and_gt_Alchornea_cordifolia_and_lt_i_and_gt_Leaves"><img alt="Research paper thumbnail of Acute Toxicity and Antipyretic Activities of a Methanolic Extract of &lt;i&gt;Alchornea cordifolia&lt;/i&gt; Leaves" class="work-thumbnail" src="https://attachments.academia-assets.com/107759909/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/109719138/Acute_Toxicity_and_Antipyretic_Activities_of_a_Methanolic_Extract_of_and_lt_i_and_gt_Alchornea_cordifolia_and_lt_i_and_gt_Leaves">Acute Toxicity and Antipyretic Activities of a Methanolic Extract of &lt;i&gt;Alchornea cordifolia&lt;/i&gt; Leaves</a></div><div class="wp-workCard_item"><span>Pharmacology &amp; Pharmacy</span><span>, 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Alchornea cordifolia (Euphorbiaceae) is a very prized plant among traditional healers in Africa. ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Alchornea cordifolia (Euphorbiaceae) is a very prized plant among traditional healers in Africa. Its leaves are used for its antipyretic properties in traditional areas. The aim of our study is to determine the acute toxicity and the antipyretic activity of a methanolic extract of Alchornea cordifolia leaves. Acute toxicity was assessed by measuring mortality, changes in body weight, spontaneous movements, and normal rectal temperature in mice. Antipyretic activity was evaluated by brewer's yeast-induced hyperpyrexia in rats according to Teotino method (1963). The antipyretic effect of methanolicextract of Alchornea cordifolia leaves was compared with paracetamol (100 mg/kg bw) orally. Groups of mice treated with doses of 6500; 3250; 1625 and 812.5mg/kg of the extract did not show any mortality, nor significant alteration of body weight, nor alteration of spontaneous movements. However, incomplete reversed dose-dependent hypothermic activity was observed with doses of 50.78; 101.56; 203.12; 406.25; and 812.5 mg/kg p.o. of the extract, showing acute toxicity of this plant. In the antipyretic assay, the extract with doses of 50.78; 101.56; 203.12; 406.25; and 812.5 mg/kg p.o. exhibited a significant dose-dependent antipyretic activity similar to paracetamol (100 mg/kg bw) in rats. Thus Alchornea cordifolia may inhibit prostaglandins-biosynthesis from hypothalamus. Our results support claims on its traditional uses in management of fever. However Alchornea cordifolia may affect hypothalamus not only during fever but also when body temperature is normal.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="506e6b44b6583ff928f5b79b47ba9552" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":107759909,"asset_id":109719138,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/107759909/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="109719138"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="109719138"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 109719138; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="109719137"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/109719137/Oxygen_species_scavenger_activities_and_phenolic_contents_of_four_West_African_plants"><img alt="Research paper thumbnail of Oxygen species scavenger activities and phenolic contents of four West African plants" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/109719137/Oxygen_species_scavenger_activities_and_phenolic_contents_of_four_West_African_plants">Oxygen species scavenger activities and phenolic contents of four West African plants</a></div><div class="wp-workCard_item"><span>Food Chemistry</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In West Africa, Alchornea cordifolia, Baphia nitida, Cassia occidentalis and Boerhavia diffusa le...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In West Africa, Alchornea cordifolia, Baphia nitida, Cassia occidentalis and Boerhavia diffusa leaves are used in food and drinks, as well as in traditional medicine, to treat rheumatic ailments which incur oxidative stress. First, these plants were evaluated for their antioxidant properties through a scavenger effect on reactive oxygen species (ROS), such as hydrogen peroxide and hypochlorous acid. All of</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="109719137"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="109719137"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 109719137; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=109719137]").text(description); $(".js-view-count[data-work-id=109719137]").attr('title', description).tooltip(); 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</script> <div class="js-work-strip profile--work_container" data-work-id="109719121"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/109719121/Effects_ofAlchornea_cordifoliaon_elastase_and_superoxide_anion_produced_by_human_neutrophils"><img alt="Research paper thumbnail of Effects ofAlchornea cordifoliaon elastase and superoxide anion produced by human neutrophils" class="work-thumbnail" src="https://attachments.academia-assets.com/108703509/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/109719121/Effects_ofAlchornea_cordifoliaon_elastase_and_superoxide_anion_produced_by_human_neutrophils">Effects ofAlchornea cordifoliaon elastase and superoxide anion produced by human neutrophils</a></div><div class="wp-workCard_item"><span>Pharmaceutical Biology</span><span>, 2009</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f966932371f569b7e201fcff369d976e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108703509,"asset_id":109719121,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108703509/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="109719121"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="109719121"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 109719121; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=109719121]").text(description); $(".js-view-count[data-work-id=109719121]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 109719121; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='109719121']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="74627915"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/74627915/Pharmacological_management_of_adverse_events_during_treatment_of_chronic_viral_hepatitis_in_three_Ivorian_university_hospitals"><img alt="Research paper thumbnail of Pharmacological management of adverse events during treatment of chronic viral hepatitis in three Ivorian university hospitals" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/74627915/Pharmacological_management_of_adverse_events_during_treatment_of_chronic_viral_hepatitis_in_three_Ivorian_university_hospitals">Pharmacological management of adverse events during treatment of chronic viral hepatitis in three Ivorian university hospitals</a></div><div class="wp-workCard_item"><span>International journal of clinical pharmacology and therapeutics</span><span>, Feb 26, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This work aims to evaluate the therapeutic survey of adverse events during antiviral treatment of...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This work aims to evaluate the therapeutic survey of adverse events during antiviral treatment of hepatitis in the three major University Hospitals in Abidjan. A retrospective cross-sectional descriptive study of 203 patients from August 1, 2015, to July 31, 2018, enumerated adverse events during antiviral treatments, drugs used for their management, and their clinical or biological impact. The following was seen: hematological disorders during treatment with pegylated interferon α-2a (88.61%) and ribavirin (77.55%), pain syndrome when using pegylated interferon α-2a (90.5%), and digestive disorders while taking sofosbuvir (60.71%) and daclatasvir (66.67%). Hematological disorders were managed with filgrastim for neutropenia and oral iron or blood transfusion for anemia and/or thrombocytopenia. Pain syndrome was treated with paracetamol. As for digestive disorders, they were most often managed with activated charcoal. Correction of the adverse events was made either using causal tre...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="74627915"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="74627915"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 74627915; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=74627915]").text(description); $(".js-view-count[data-work-id=74627915]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 74627915; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='74627915']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=74627915]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":74627915,"title":"Pharmacological management of adverse events during treatment of chronic viral hepatitis in three Ivorian university hospitals","internal_url":"https://www.academia.edu/74627915/Pharmacological_management_of_adverse_events_during_treatment_of_chronic_viral_hepatitis_in_three_Ivorian_university_hospitals","owner_id":151130319,"coauthors_can_edit":true,"owner":{"id":151130319,"first_name":"Geneviève","middle_initials":null,"last_name":"N'guessan-Irié","page_name":"GenevièveNguessanIrié","domain_name":"independent","created_at":"2020-03-25T09:44:04.654-07:00","display_name":"Geneviève N'guessan-Irié","url":"https://independent.academia.edu/Genevi%C3%A8veNguessanIri%C3%A9"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="74627914"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/74627914/Beta_lactams_and_Aminoglycosides_in_Neonates_at"><img alt="Research paper thumbnail of Beta-lactams and Aminoglycosides in Neonates at" class="work-thumbnail" src="https://attachments.academia-assets.com/82712701/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/74627914/Beta_lactams_and_Aminoglycosides_in_Neonates_at">Beta-lactams and Aminoglycosides in Neonates at</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Aim: In Ivory Coast, neonatal infections are very frequent. However the antibacterial therapy of ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Aim: In Ivory Coast, neonatal infections are very frequent. However the antibacterial therapy of these diseases is not still the object of a national consensus. Then it seems important to make the current situation of antibacterial therapy in neonates in reference Hospitals like the University Hospital of Cocody. The aim of this study was to analyze the practice of antibacterial care in neonatal infections there with regard to international recommendations, if need be, to make propositions for improvement. Methods: Two hundred and fourteen neonates hospitalized for infection except parasitic or viral disorders were recruited for seven-month transversal study. Hospital practices were observed and detailed antibacterial therapy was noted. Results: Antibacterial therapy was dominated by double-antibacterial therapy (98.13%). This concerned in first intention Amoxicillin 100 Mg/Kg twice a day or Ceftriaxone 100 Mg/Kg once a day in direct intravenous injection + Netilmicin or Gentamycin ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7834a02f7f94984b917b6f34c3ae16ea" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":82712701,"asset_id":74627914,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/82712701/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="74627914"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="74627914"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 74627914; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="74627913"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/74627913/Bilan_dune_d%C3%A9cennie_dalertes_m%C3%A9dicamenteuses_en_C%C3%B4te_dIvoire_de_2001_%C3%A0_2010"><img alt="Research paper thumbnail of Bilan d'une décennie d'alertes médicamenteuses en Côte d'Ivoire de 2001 à 2010" class="work-thumbnail" src="https://attachments.academia-assets.com/83502769/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/74627913/Bilan_dune_d%C3%A9cennie_dalertes_m%C3%A9dicamenteuses_en_C%C3%B4te_dIvoire_de_2001_%C3%A0_2010">Bilan d'une décennie d'alertes médicamenteuses en Côte d'Ivoire de 2001 à 2010</a></div><div class="wp-workCard_item"><span>The´rapie (Paris)</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">-Objectif. Ce travail vise un suivi plus efficient de la sécurité des médicaments à usage humain ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">-Objectif. Ce travail vise un suivi plus efficient de la sécurité des médicaments à usage humain sur le marché ivoirien. Méthode. La direction de la pharmacie et du médicament (DPM) a répertorié toutes les alertes médicamenteuses de 2001 à 2010. Résultats. Il ressort 237 alertes médicamenteuses dont 145 arrêts de commercialisation, 55 retraits de lots, 33 notes d'information et 4 levées de suspension de médicaments. Ces alertes proviennent majoritairement des laboratoires pharmaceutiques (49 %) et de ANSM (ex-Afssaps) [43 %]. Elles concernent principalement les médicaments à visée antiinfectieuse (22 %) et pneumologique (18 %) et leurs motivations sont tant industrielles avec majoritairement des raisons commerciales (27 %) que de pharmacovigilance dominées par les rapports bénéfice/risque défavorables. Conclusion. Ces résultats constituent une base de données importante pour la surveillance du marché des médicaments sur le territoire ivoirien et une motivation supplémentaire pour accélérer la mise en place d'un véritable centre national de pharmacovigilance.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2f85a84bde7dbb6789d9871fed3ef0d8" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":83502769,"asset_id":74627913,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/83502769/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="74627913"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="74627913"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 74627913; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="74627912"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/74627912/Isolation_and_Spasmolytic_Evaluation_of_New_Alkaloids_from_i_Dichrostachys_cinerea_i_L_Wight_et_Arn_Fabaceae_"><img alt="Research paper thumbnail of Isolation and Spasmolytic Evaluation of New Alkaloids from <i>Dichrostachys cinerea</i> (L.) Wight et Arn. (Fabaceae)" class="work-thumbnail" src="https://attachments.academia-assets.com/82712699/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/74627912/Isolation_and_Spasmolytic_Evaluation_of_New_Alkaloids_from_i_Dichrostachys_cinerea_i_L_Wight_et_Arn_Fabaceae_">Isolation and Spasmolytic Evaluation of New Alkaloids from <i>Dichrostachys cinerea</i> (L.) Wight et Arn. (Fabaceae)</a></div><div class="wp-workCard_item"><span>Pharmacology and Pharmacy</span><span>, 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Dichrostachys cinerea (L.) Wight et Arn. (Fabaceae) root bark is used in Ivorian Traditional Medi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Dichrostachys cinerea (L.) Wight et Arn. (Fabaceae) root bark is used in Ivorian Traditional Medicine to treat asthma, which is a respiratory disorder characterized by inflammation and the restriction of tracheal muscles obstructing the air circulation. The tracheal relaxant effect of a crude aqueous-alcoholic extract of the plant root bark was previously shown. For the present study, alkaloids were isolated from the same extract and investigated ex vivo in C57Bl/6j mice isolated trachea contracted with carbachol 1 µM, in comparison with a reference bronchodilatator, i.e. salbutamol. Two extraction procedures allowed isolating 2 Alkaloids that monodimensional and bi-dimensional nuclear magnetic resonance (NMR) and mass specters allowed identifying a pyrolidine structure type nucleus with a long bi-hydroxyled alkyl chain. Alkaloid 1, carrier of a sugar, is a glycoside of Alkaloid 2. Both alkaloids induced similar spasmolytic effects, but Alkaloid 1 was more effective than Alkaloid 2 at 9 × 10 −6 M (p ˂ 0.01), 3 × 10 −5 M, and 9 × 10 −5 M (p ˂ 0.001). Salbutamol induced its spasmolytic effect in a different way, and its maximal effect E max (less than 30%) was obtained at 9 × 10 −6 M, while E max of both alkaloids (100%) was obtained at 3 × 10 −4 M.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8a8c5e62e6b103fb43f462eefa8611fa" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":82712699,"asset_id":74627912,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/82712699/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="74627912"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="74627912"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 74627912; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=74627912]").text(description); $(".js-view-count[data-work-id=74627912]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 74627912; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='74627912']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8a8c5e62e6b103fb43f462eefa8611fa" } } $('.js-work-strip[data-work-id=74627912]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":74627912,"title":"Isolation and Spasmolytic Evaluation of New Alkaloids from \u003ci\u003eDichrostachys cinerea\u003c/i\u003e (L.) 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(Fabaceae)","internal_url":"https://www.academia.edu/74627912/Isolation_and_Spasmolytic_Evaluation_of_New_Alkaloids_from_i_Dichrostachys_cinerea_i_L_Wight_et_Arn_Fabaceae_","owner_id":151130319,"coauthors_can_edit":true,"owner":{"id":151130319,"first_name":"Geneviève","middle_initials":null,"last_name":"N'guessan-Irié","page_name":"GenevièveNguessanIrié","domain_name":"independent","created_at":"2020-03-25T09:44:04.654-07:00","display_name":"Geneviève N'guessan-Irié","url":"https://independent.academia.edu/Genevi%C3%A8veNguessanIri%C3%A9"},"attachments":[{"id":82712699,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/82712699/thumbnails/1.jpg","file_name":"PaperDownload.pdf","download_url":"https://www.academia.edu/attachments/82712699/download_file","bulk_download_file_name":"Isolation_and_Spasmolytic_Evaluation_of.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/82712699/PaperDownload-libre.pdf?1648310425=\u0026response-content-disposition=attachment%3B+filename%3DIsolation_and_Spasmolytic_Evaluation_of.pdf\u0026Expires=1739793910\u0026Signature=beitiXwEwSrOpZh-rY0U6bSNlZJPo2arQYWXSJtcwYyEIkMC2IyVvKHoZdc-p6V54nDt5QdnRE6tThRmiQMcr-vohx-N~T6z0f6Q6pOJ8EjZP25odCmQo-EsWeCH7WJBuCZmkr9KpdswWeSOJuhQRxaq7BlysE-KszYrgrl54NbNvzcUyRREjzIMawzmC6yQW5FbANofKWonHH6b5QA4JGtCJMSwCEM6ZecFPhx0tVxk-HpRXQmvj8f78ZWxDK0vn5RNw6R8h3qFTj24kU0AiFAhEB4vLOH6RnDUxQji1rlrKME0cWSm6rfgLUYYCm00r-gUyzfhNI84NEpx1gLIkQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":82712700,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/82712700/thumbnails/1.jpg","file_name":"PaperDownload.pdf","download_url":"https://www.academia.edu/attachments/82712700/download_file","bulk_download_file_name":"Isolation_and_Spasmolytic_Evaluation_of.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/82712700/PaperDownload-libre.pdf?1648310424=\u0026response-content-disposition=attachment%3B+filename%3DIsolation_and_Spasmolytic_Evaluation_of.pdf\u0026Expires=1739793910\u0026Signature=VY-JXuNCc9WjtPGrUg03UWfav6FjPwUDztewFnGmFMmQIfCC64EtjiA7v3iQ6akXHuPj1wTJXkpttRCBiCEeiSQPRG75MDAjMH8VBbq8Sg3HlNOWLY3XnvaxN9AmrO8TJgLR0kPq6uCcr~U2M5CEa-HCDsqJDV-Bwom9FF0K-0finBamIGbfSixwnvNx6jlX0JYcE6iRaxMHFbi7VXnVs3R4TT0Hlz84F4wO01wFXbKMnbT8yYhVceuLKqghcdgeACUE8poPuu1azAqF6N7dARJQNkrVxK6HIqBLguTJ81PETwBUmzXfuroaL8gLvsDnfl9pGFEMVVW3jdX8m6jMmw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="74627911"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/74627911/Review_of_Experimental_Pharmacological_Studies_of_Plants_Used_for_Asthma_Management_in_Africa"><img alt="Research paper thumbnail of Review of Experimental Pharmacological Studies of Plants Used for Asthma Management in Africa" class="work-thumbnail" src="https://attachments.academia-assets.com/82712737/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/74627911/Review_of_Experimental_Pharmacological_Studies_of_Plants_Used_for_Asthma_Management_in_Africa">Review of Experimental Pharmacological Studies of Plants Used for Asthma Management in Africa</a></div><div class="wp-workCard_item"><span>International Journal of Pharmaceutics & Pharmacology</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objectives: The aim was to contribute to the promotion of medicinal plants used in Africa for man...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objectives: The aim was to contribute to the promotion of medicinal plants used in Africa for management of asthma by analyzing their experimental pharmacological evaluation data. Methods: We carried out a systematic review of the literature based on the following research equations in English and in French: « médecine traditionnelle africaine » ET « asthma » ; « African traditional medicine » AND « asthma » or « Medicine African traditional » AND « asthma » ; « plantes médicinales » ET « asthma » ET « antispasmodique » ; «medicinal plants » AND « asthma » AND « anti-spasmodic » ; « plantes médicinales » ET « asthma » ET « anti-inflammatoire » ; «medicinal plants » AND « asthma » AND « anti-inflammatory ». Results: The study revealed 184 medicinal plants used in Africa for the treatment of asthma, 34 of which showed pharmacological properties in favor of their use. In animal experiments, 18 of these plants exerted a spasmolytic effect, 22 an anti-inflammatory effect and 6 both effec...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5822addd15ac533100e67dcb39c0c231" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":82712737,"asset_id":74627911,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/82712737/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="74627911"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="74627911"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 74627911; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=74627911]").text(description); $(".js-view-count[data-work-id=74627911]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 74627911; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='74627911']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="74627866"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/74627866/Hyperglycaemia_lowering_activity_and_hypoglycaemic_risk_assessment_of_Sarenta_an_Ivorian_traditional_herbal_remedy"><img alt="Research paper thumbnail of Hyperglycaemia lowering activity and hypoglycaemic risk assessment of Sarenta, an Ivorian traditional herbal remedy" class="work-thumbnail" src="https://attachments.academia-assets.com/82712710/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/74627866/Hyperglycaemia_lowering_activity_and_hypoglycaemic_risk_assessment_of_Sarenta_an_Ivorian_traditional_herbal_remedy">Hyperglycaemia lowering activity and hypoglycaemic risk assessment of Sarenta, an Ivorian traditional herbal remedy</a></div><div class="wp-workCard_item"><span>International Journal of Basic & Clinical Pharmacology</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Diabetes remains a major public health problem for which traditional medicine is a be...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Diabetes remains a major public health problem for which traditional medicine is a better therapeutic alternative for low-income populations, including African populations. The aim of this work was to evaluate the effect of Sarenta, an herbal preparation used in Ivorian traditional medicine as anti-diabetic, on hyperglycaemia and on basic glycaemia.Methods: Hyperglycaemia lowering activity was led in rats receiving glucose at 5 g/kg body weight by gavage after oral pre-treatment with either Sarenta at 125, 206 or 209.5 mg/kg b. wt., either glibenclamide at 10 mg/kg b. wt., or physiological saline solution. Hypoglycaemic risk was assessed by administering the same doses of Sarenta to native i.e. NaCl-treated rats. For both tests, blood glucose was measured before any substance was administered and then every hour for 4 hours.Results: After 4 hours, Sarenta at 206 mg/kg b. wt. and 209.5 mg/kg b. wt. significantly reduced the induced hyperglycaemia in rats by 33.87% and 37....</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9a65829d961db0fd8a640ab41e8753ce" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":82712710,"asset_id":74627866,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/82712710/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="74627866"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="74627866"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 74627866; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9a65829d961db0fd8a640ab41e8753ce" } } $('.js-work-strip[data-work-id=74627866]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":74627866,"title":"Hyperglycaemia lowering activity and hypoglycaemic risk assessment of Sarenta, an Ivorian traditional herbal remedy","internal_url":"https://www.academia.edu/74627866/Hyperglycaemia_lowering_activity_and_hypoglycaemic_risk_assessment_of_Sarenta_an_Ivorian_traditional_herbal_remedy","owner_id":151130319,"coauthors_can_edit":true,"owner":{"id":151130319,"first_name":"Geneviève","middle_initials":null,"last_name":"N'guessan-Irié","page_name":"GenevièveNguessanIrié","domain_name":"independent","created_at":"2020-03-25T09:44:04.654-07:00","display_name":"Geneviève N'guessan-Irié","url":"https://independent.academia.edu/Genevi%C3%A8veNguessanIri%C3%A9"},"attachments":[{"id":82712710,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/82712710/thumbnails/1.jpg","file_name":"2570.pdf","download_url":"https://www.academia.edu/attachments/82712710/download_file","bulk_download_file_name":"Hyperglycaemia_lowering_activity_and_hyp.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/82712710/2570-libre.pdf?1648310425=\u0026response-content-disposition=attachment%3B+filename%3DHyperglycaemia_lowering_activity_and_hyp.pdf\u0026Expires=1739793910\u0026Signature=cLzGo4DEhEpwu30G9GlcD-7nKlJSQP7-p9BvBP-89NV3PeNJ5lJXkrgtJD0xur14eK9WjFbmnqz2F2-Z259NSx28kO4fjCg5N6jh9O8jvRwio8OzEu8cXnSWFA6-jGu8FVLez7dYvKUOuB7T~ZlBuIjAX-ZFMotrAwmES0l2rb3TWWCs9xbmffmzpSofhUPWYga3kYqy1gzIWUq3Bh3InFvnycq~inHtQF6era5NAkRjn0rgrobBqDsUYVzLXZRb0gXYnblm9r5ATf3QFavRzXRm1TiEu03V~~0o9Bklk4Ige7n-zrpYb2Bsp7dCxyhWwZICdxk~I~1j2tBo~LqwHQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="66116475"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/66116475/_Summarizing_of_medicinal_alerts_in_Ivory_Coast_from_2001_till_2010_"><img alt="Research paper thumbnail of [Summarizing of medicinal alerts in Ivory Coast from 2001 till 2010]" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/66116475/_Summarizing_of_medicinal_alerts_in_Ivory_Coast_from_2001_till_2010_">[Summarizing of medicinal alerts in Ivory Coast from 2001 till 2010]</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">UNLABELLED STUDY&#39;S AIM: This study aims a more efficient follow-up of the safety of medicines...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">UNLABELLED STUDY&#39;S AIM: This study aims a more efficient follow-up of the safety of medicines with human usage on the Ivory Coast territory. METHOD The structure responsible for pharmacovigilance in Ivory Coast i.e. DPM listed the medicinal alerts from 2001 till 2010. RESULTS It emerges 237 medicinal alerts among which 145 stops of marketing, 55 withdrawals of lots, 33 information notes and 4 levying of suspension of medicines. These alerts result mainly from pharmaceutical companies (49%) and the French Drug Agency or ANSM (ex-Afssaps) (43%). They mainly concern drugs of infectious target (22%) and pneumology (18%) and their motivations are so much industrial with mainly commercial reasons (27%) as of pharmacovigilance dominated by unfavorable profit/risk connections. CONCLUSION These results constitute an important database for the survey of the medicines market in Ivory Coast and an additional motivation to accelerate the implementation of a real national center of pharmacovi...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="66116475"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="66116475"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 66116475; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=66116475]").text(description); $(".js-view-count[data-work-id=66116475]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 66116475; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='66116475']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=66116475]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":66116475,"title":"[Summarizing of medicinal alerts in Ivory Coast from 2001 till 2010]","internal_url":"https://www.academia.edu/66116475/_Summarizing_of_medicinal_alerts_in_Ivory_Coast_from_2001_till_2010_","owner_id":151130319,"coauthors_can_edit":true,"owner":{"id":151130319,"first_name":"Geneviève","middle_initials":null,"last_name":"N'guessan-Irié","page_name":"GenevièveNguessanIrié","domain_name":"independent","created_at":"2020-03-25T09:44:04.654-07:00","display_name":"Geneviève N'guessan-Irié","url":"https://independent.academia.edu/Genevi%C3%A8veNguessanIri%C3%A9"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="66116406"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/66116406/Pharmacotherapeutic_aspect_of_antibiotic_therapy_during_acute_community_acquired_pneumonia_in_adults_at_the_University_Hospital_of_Cocody_Abidjan_"><img alt="Research paper thumbnail of Pharmacotherapeutic aspect of antibiotic therapy during acute community-acquired pneumonia in adults at the University Hospital of Cocody (Abidjan)" class="work-thumbnail" src="https://attachments.academia-assets.com/77498996/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/66116406/Pharmacotherapeutic_aspect_of_antibiotic_therapy_during_acute_community_acquired_pneumonia_in_adults_at_the_University_Hospital_of_Cocody_Abidjan_">Pharmacotherapeutic aspect of antibiotic therapy during acute community-acquired pneumonia in adults at the University Hospital of Cocody (Abidjan)</a></div><div class="wp-workCard_item"><span>Int. Journal of Clinical Pharmacology and Therapeutics</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">OBJECTIVE Acute community-acquired pneumonia in Côte d&#39;Ivoire, mainly in the pneumology units...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">OBJECTIVE Acute community-acquired pneumonia in Côte d&#39;Ivoire, mainly in the pneumology units, is the second most common cause of hospitalization after tuberculosis. This study aimed to evaluate the compliance of antibiotic therapy during bacterial acute community-acquired pneumonia with international guidelines serving as frame of reference at the University Hospital of Cocody. MATERIALS AND METHODS We carried out a descriptive retrospective and analytic study on 62 hospitalized patients from December 1, 2008 to November 30, 2010 in the Pneumophtisiology department at the University Hospital of Cocody (Abidjan). The prescription of antibiotics was compared with the recommendations of the 15th consensus conference on anti-infectious therapy by the Société de Pathologie Infectieuse de Langue Francaise (SPILF) (French Speaking Society of Infectious Pathology) held in 2006. RESULTS The main antibiotics prescribed were amoxicillin-clavulanic acid (42.27%), netilmicin (34.5%) and ciprofloxacin (6%). The antibiotic therapy diagrams were dominated by an antibiotic bitherapy; the association of amoxicillin-clavulanic acid+netilmicin was observed in 80.64% of the prescriptions. An antibiotic monotherapy was reported in 14.52% of the prescriptions. Apyrexia at 72 hours was obtained with 64% of the patients with nonstop antibiotic treatment, 24% of them presented a lack of apyrexia, and 12% of them died. The lack of apyrexia at 72 hours treatment correlated with concomitant administration of cotrimoxazole with prophylactic doses among HIV positive patients. The level of the compliance with the SPILF recommendations is low (3.6%). CONCLUSION Thus, our results convey the necessity to draw up national recommendations because of the specific realities of countries with limited incomes.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="42dd841c13b6389a96f648cce79cf186" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":77498996,"asset_id":66116406,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/77498996/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="66116406"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="66116406"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 66116406; 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