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cell carcinoma</title> <meta name="description" content="Search results for: squamous cell carcinoma"> <meta name="keywords" content="squamous cell carcinoma"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block 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action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="squamous cell carcinoma"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 3845</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: squamous cell carcinoma</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3635</span> Resistive Switching in TaN/AlNx/TiN Cell</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hsin-Ping%20Huang">Hsin-Ping Huang</a>, <a href="https://publications.waset.org/abstracts/search?q=Shyankay%20Jou"> Shyankay Jou</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Resistive switching of aluminum nitride (AlNx) thin film was demonstrated in a TaN/AlNx/TiN memory cell that was prepared by sputter deposition techniques. The memory cell showed bipolar switching of resistance between +3.5 V and –3.5 V. The resistance ratio of high resistance state (HRS) to low resistance state (HRS), RHRS/RLRS, was about 2 over 100 cycles of endurance test. Both the LRS and HRS of the memory cell exhibited ohmic conduction at low voltages and Poole-Frenkel emission at high voltages. The electrical conduction in the TaN/AlNx/TiN memory cell was possibly attributed to the interactions between charges and defects in the AlNx film. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=aluminum%20nitride" title="aluminum nitride">aluminum nitride</a>, <a href="https://publications.waset.org/abstracts/search?q=nonvolatile%20memory" title=" nonvolatile memory"> nonvolatile memory</a>, <a href="https://publications.waset.org/abstracts/search?q=resistive%20switching" title=" resistive switching"> resistive switching</a>, <a href="https://publications.waset.org/abstracts/search?q=thin%20films" title=" thin films"> thin films</a> </p> <a href="https://publications.waset.org/abstracts/7604/resistive-switching-in-tanalnxtin-cell" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/7604.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">399</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3634</span> The Influence of Nutritional and Immunological Status on the Prognosis of Head and Neck Cancer</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ching-Yi%20Yiu">Ching-Yi Yiu</a>, <a href="https://publications.waset.org/abstracts/search?q=Hui-Chen%20Hsu"> Hui-Chen Hsu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Objectives: Head and neck cancer (HNC) is a big global health problem in the world. Despite the development of diagnosis and treatment, the overall survival of HNC is still low. The well recognition of the interaction of the host immune system and cancer cells has led to realizing the processes of tumor initiation, progression and metastasis. Many systemic inflammatory responses have been shown to play a crucial role in cancer progression. The pre and post-treatment nutritional and immunological status of HNC patients is a reliable prognostic indicator of tumor outcomes and survivors. Methods: Between July 2020 to June 2022, We have enrolled 60 HNC patients, including 59 males and 1 female, in Chi Mei Medical Center, Liouying, Taiwan. The age distribution was from 37 to 81 years old (y/o), with a mean age of 57.6 y/o. We evaluated the pre-and post-treatment nutritional and immunological status of these HNC patients with body weight, body weight loss, body mass index (BMI), whole blood count including hemoglobin (Hb), lymphocyte, neutrophil and platelet counts, biochemistry including prealbumin, albumin, c-reactive protein (CRP), with the time period of before treatment, post-treatment 3 and 6 months. We calculated the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) to assess how these biomarkers influence the outcomes of HNC patients. Results: We have carcinoma of the hypopharynx in 21 cases with 35％, carcinoma of the larynx in 9 cases, carcinoma of the tonsil and tongue every 6 cases, carcinoma soft palate and tongue base every 5 cases, carcinoma of buccal mucosa, retromolar trigone and mouth floor every 2 cases, carcinoma of the hard palate and low lip each 1 case. There were stage I 15 cases, stage II 13 cases, stage III 6 cases, stage IVA 10 cases, and stage IVB 16 cases. All patients have received surgery, chemoradiation therapy or combined therapy. We have wound infection in 6 cases, 2 cases of pharyngocutaneous fistula, flap necrosis in 2 cases, and mortality in 6 cases. In the wound infection group, the average BMI is 20.4 kg/m2; the average Hb is 12.9 g/dL, the average albumin is 3.5 g/dL, the average NLR is 6.78, and the average PLR is 243.5. In the PC fistula and flap necrosis group, the average BMI is 21.65 kg/m2; the average Hb is 11.7 g/dL, the average albumin is 3.15 g/dL, average NLR is 13.28, average PLR is 418.84. In the mortality group, the average BMI is 22.3 kg/m2; the average Hb is 13.58 g/dL, the average albumin is 3.77 g/dL, the average NLR is 6.06, and the average PLR is 275.5. Conclusion: HNC is a big challenging public health problem worldwide, especially in the high prevalence of betel nut consumption area Taiwan. Besides the definite risk factors of smoking, drinking and betel nut related, the other biomarkers may play significant prognosticators in the HNC outcomes. We concluded that the average BMI is less than 22 kg/m2, the average Hb is low than 12.0 g/dL, the average albumin is low than 3.3 g/dL, the average NLR is low than 3, and the average PLR is more than 170, the surgical complications and mortality will be increased, and the prognosis is poor in HNC patients. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=nutritional" title="nutritional">nutritional</a>, <a href="https://publications.waset.org/abstracts/search?q=immunological" title=" immunological"> immunological</a>, <a href="https://publications.waset.org/abstracts/search?q=neutrophil-to-lymphocyte%20ratio" title=" neutrophil-to-lymphocyte ratio"> neutrophil-to-lymphocyte ratio</a>, <a href="https://publications.waset.org/abstracts/search?q=paltelet-to-lymphocyte%20ratio." title=" paltelet-to-lymphocyte ratio."> paltelet-to-lymphocyte ratio.</a> </p> <a href="https://publications.waset.org/abstracts/164466/the-influence-of-nutritional-and-immunological-status-on-the-prognosis-of-head-and-neck-cancer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/164466.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">79</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3633</span> Biological Significance of Long Intergenic Noncoding RNA LINC00273 in Lung Cancer Cell Metastasis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ipsita%20Biswas">Ipsita Biswas</a>, <a href="https://publications.waset.org/abstracts/search?q=Arnab%20Sarkar"> Arnab Sarkar</a>, <a href="https://publications.waset.org/abstracts/search?q=Ashikur%20Rahaman"> Ashikur Rahaman</a>, <a href="https://publications.waset.org/abstracts/search?q=Gopeswar%20Mukherjee"> Gopeswar Mukherjee</a>, <a href="https://publications.waset.org/abstracts/search?q=Subhrangsu%20Chatterjee"> Subhrangsu Chatterjee</a>, <a href="https://publications.waset.org/abstracts/search?q=Shamee%20Bhattacharjee"> Shamee Bhattacharjee</a>, <a href="https://publications.waset.org/abstracts/search?q=Deba%20Prasad%20Mandal"> Deba Prasad Mandal</a> </p> <p class="card-text"><strong>Abstract:</strong></p> One of the major reasons for the high mortality rate of lung cancer is the substantial delays in disease detection at late metastatic stages. It is of utmost importance to understand the detailed molecular signaling and detect the molecular markers that can be used for the early diagnosis of cancer. Several studies explored the emerging roles of long noncoding RNAs (lncRNAs) in various cancers as well as lung cancer. A long non-coding RNA LINC00273 was recently discovered to promote cancer cell migration and invasion, and its positive correlation with the pathological stages of metastasis may prove it to be a potential target for inhibiting cancer cell metastasis. Comparing real-time expression of LINC00273 in various human clinical cancer tissue samples with normal tissue samples revealed significantly higher expression in cancer tissues. This long intergenic noncoding RNA was found to be highly expressed in human liver tumor-initiating cells, human gastric adenocarcinoma AGS cell line, as well as human non-small cell lung cancer A549 cell line. SiRNA and shRNA-induced knockdown of LINC00273 in both in vitro and in vivo nude mice significantly subsided AGS and A549 cancer cell migration and invasion. LINC00273 knockdown also reduced TGF-β induced SNAIL, SLUG, VIMENTIN, ZEB1 expression, and metastasis in A549 cells. Plenty of reports have suggested the role of microRNAs of the miR200 family in reversing epithelial to mesenchymal transition (EMT) by inhibiting ZEB transcription factors. In this study, hsa-miR-200a-3p was predicted via IntaRNA-Freiburg RNA tools to be a potential target of LINC00273 with a negative free binding energy of −8.793 kcal/mol, and this interaction was verified as a confirmed target of LINC00273 by RNA pulldown, real-time PCR and luciferase assay. Mechanistically, LINC00273 accelerated TGF-β induced EMT by sponging hsa-miR-200a-3p which in turn liberated ZEB1 and promoted prometastatic functions in A549 cells in vitro as verified by real-time PCR and western blotting. The similar expression patterns of these EMT regulatory pathway molecules, viz. LINC00273, hsa-miR-200a-3p, ZEB1 and TGF-β, were also detected in various clinical samples like breast cancer tissues, oral cancer tissues, lung cancer tissues, etc. Overall, this LINC00273 mediated EMT regulatory signaling can serve as a potential therapeutic target for the prevention of lung cancer metastasis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=epithelial%20to%20mesenchymal%20transition" title="epithelial to mesenchymal transition">epithelial to mesenchymal transition</a>, <a href="https://publications.waset.org/abstracts/search?q=long%20noncoding%20RNA" title=" long noncoding RNA"> long noncoding RNA</a>, <a href="https://publications.waset.org/abstracts/search?q=microRNA" title=" microRNA"> microRNA</a>, <a href="https://publications.waset.org/abstracts/search?q=non-small-cell%20lung%20carcinoma" title=" non-small-cell lung carcinoma"> non-small-cell lung carcinoma</a> </p> <a href="https://publications.waset.org/abstracts/143383/biological-significance-of-long-intergenic-noncoding-rna-linc00273-in-lung-cancer-cell-metastasis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/143383.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">156</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3632</span> Non-Steroidal Microtubule Disrupting Analogues Induce Programmed Cell Death in Breast and Lung Cancer Cell Lines</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Marcel%20Verwey">Marcel Verwey</a>, <a href="https://publications.waset.org/abstracts/search?q=Anna%20M.%20Joubert"> Anna M. Joubert</a>, <a href="https://publications.waset.org/abstracts/search?q=Elsie%20M.%20Nolte"> Elsie M. Nolte</a>, <a href="https://publications.waset.org/abstracts/search?q=Wolfgang%20Dohle"> Wolfgang Dohle</a>, <a href="https://publications.waset.org/abstracts/search?q=Barry%20V.%20L.%20Potter"> Barry V. L. Potter</a>, <a href="https://publications.waset.org/abstracts/search?q=Anne%20E.%20Theron"> Anne E. Theron</a> </p> <p class="card-text"><strong>Abstract:</strong></p> A tetrahydroisoquinolinone (THIQ) core can be used to mimic the A,B-ring of colchicine site-binding microtubule disruptors such as 2-methoxyestradiol in the design of anti-cancer agents. Steroidomimeric microtubule disruptors were synthesized by introducing C'2 and C'3 of the steroidal A-ring to C'6 and C'7 of the THIQ core and by introducing a decorated hydrogen bond acceptor motif projecting from the steroidal D-ring to N'2. For this in vitro study, four non-steroidal THIQ-based analogues were investigated and comparative studies were done between the non-sulphamoylated compound STX 3450 and the sulphamoylated compounds STX 2895, STX 3329 and STX 3451. The objective of this study was to investigate the modes of cell death induced by these four THIQ-based analogues in A549 lung carcinoma epithelial cells and metastatic breast adenocarcinoma MDA-MB-231 cells. Cytotoxicity studies to determine the half maximal growth inhibitory concentrations were done using spectrophotometric quantification via crystal violet staining and lactate dehydrogenase (LDH) assays. Microtubule integrity and morphologic changes of exposed cells were investigated using polarization-optical transmitted light differential interference contrast microscopy, transmission electron microscopy and confocal microscopy. Flow cytometric quantification was used to determine apoptosis induction and the effect that THIQ-based analogues have on cell cycle progression. Signal transduction pathways were elucidated by quantification of the mitochondrial membrane integrity, cytochrome c release and caspase 3, -6 and -8 activation. Induction of autophagic cell death by the THIQ-based analogues was investigated by morphological assessment of fluorescent monodansylcadaverine (MDC) staining of acidic vacuoles and by quantifying aggresome formation via flow cytometry. Results revealed that these non-steroidal microtubule disrupting analogues inhibited 50% of cell growth at nanomolar concentrations. Immunofluorescence microscopy indicated microtubule depolarization and the resultant mitotic arrest was further confirmed through cell cycle analysis. Apoptosis induction via the intrinsic pathway was observed due to depolarization of the mitochondrial membrane, induction of cytochrome c release as well as, caspase 3 activation. Potential involvement of programmed cell death type II was observed due to the presence of acidic vacuoles and aggresome formation. Necrotic cell death did not contribute significantly, indicated by stable LDH levels. This in vitro study revealed the induction of the intrinsic apoptotic pathway as well as possible involvement of autophagy after exposure to these THIQ-based analogues in both MDA-MB-231- and A549 cells. Further investigation of this series of anticancer drugs still needs to be conducted to elucidate the temporal, mechanistic and functional crosstalk mechanisms between the two observed programmed cell deaths pathways. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=apoptosis" title="apoptosis">apoptosis</a>, <a href="https://publications.waset.org/abstracts/search?q=autophagy" title=" autophagy"> autophagy</a>, <a href="https://publications.waset.org/abstracts/search?q=cancer" title=" cancer"> cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=microtubule%20disruptor" title=" microtubule disruptor"> microtubule disruptor</a> </p> <a href="https://publications.waset.org/abstracts/52128/non-steroidal-microtubule-disrupting-analogues-induce-programmed-cell-death-in-breast-and-lung-cancer-cell-lines" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/52128.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">253</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3631</span> Theoretical Analysis of Graded Interface CdS/CIGS Solar Cell</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hassane%20Ben%20Slimane">Hassane Ben Slimane</a>, <a href="https://publications.waset.org/abstracts/search?q=Dennai%20Benmoussa"> Dennai Benmoussa</a>, <a href="https://publications.waset.org/abstracts/search?q=Abderrachid%20Helmaoui"> Abderrachid Helmaoui</a> </p> <p class="card-text"><strong>Abstract:</strong></p> We have theoretically calculated the photovoltaic conversion efficiency of a graded interface CdS/CIGS solar cell, which can be experimentally fabricated. Because the conduction band discontinuity or spike in an abrupt heterojunction CdS/CIGS solar cell can hinder the separation of hole-electron by electric field, a graded interface layer is uses to eliminate the spike and reduces recombination in space charge region. This paper describes the role of the graded band gap interface layer in decreasing the performance of the heterojunction cell. By optimizing the thickness of the graded region, an improvement of conversion efficiency has been observed in comparison to the conventional CIGS system. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=heterojunction" title="heterojunction">heterojunction</a>, <a href="https://publications.waset.org/abstracts/search?q=solar%20cell" title=" solar cell"> solar cell</a>, <a href="https://publications.waset.org/abstracts/search?q=graded%20interface" title=" graded interface"> graded interface</a>, <a href="https://publications.waset.org/abstracts/search?q=CIGS" title=" CIGS "> CIGS </a> </p> <a href="https://publications.waset.org/abstracts/20359/theoretical-analysis-of-graded-interface-cdscigs-solar-cell" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/20359.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">402</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3630</span> Effects of the Ambient Temperature and the Defect Density on the Performance the Solar Cell (HIT)</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Bouzaki%20Mohammed%20Moustafa">Bouzaki Mohammed Moustafa</a>, <a href="https://publications.waset.org/abstracts/search?q=Benyoucef%20Boumediene"> Benyoucef Boumediene</a>, <a href="https://publications.waset.org/abstracts/search?q=Benouaz%20Tayeb"> Benouaz Tayeb</a>, <a href="https://publications.waset.org/abstracts/search?q=Benhamou%20Amina"> Benhamou Amina</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The ambient temperature and the defects density in the Hetero-junction with Intrinsic Thin layers solar cells (HIT) strongly influence their performances. In first part, we presented the bands diagram on the front/back simulated solar cell based on a-Si: H / c-Si (p)/a-Si:h. In another part, we modeled the following layers structure: ZnO/a-Si:H(n)/a-Si:H(i)/c-Si(p)/a-Si:H(p)/Ag where we studied the effect of the ambient temperature and the defects density in the gap of the crystalline silicon layer on the performance of the heterojunction solar cell with intrinsic layer (HIT). <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=heterojunction%20solar%20cell" title="heterojunction solar cell">heterojunction solar cell</a>, <a href="https://publications.waset.org/abstracts/search?q=solar%20cell%20performance" title=" solar cell performance"> solar cell performance</a>, <a href="https://publications.waset.org/abstracts/search?q=bands%20diagram" title=" bands diagram"> bands diagram</a>, <a href="https://publications.waset.org/abstracts/search?q=ambient%20temperature" title=" ambient temperature"> ambient temperature</a>, <a href="https://publications.waset.org/abstracts/search?q=defect%20density" title=" defect density "> defect density </a> </p> <a href="https://publications.waset.org/abstracts/21496/effects-of-the-ambient-temperature-and-the-defect-density-on-the-performance-the-solar-cell-hit" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/21496.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">508</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3629</span> Epigenomic Analysis of Lgr5+ Stem Cells in Gastrointestinal Tract</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hyo-Min%20Kim">Hyo-Min Kim</a>, <a href="https://publications.waset.org/abstracts/search?q=Seokjin%20Ham"> Seokjin Ham</a>, <a href="https://publications.waset.org/abstracts/search?q=Mi-Joung%20Yoo"> Mi-Joung Yoo</a>, <a href="https://publications.waset.org/abstracts/search?q=Minseon%20Kim"> Minseon Kim</a>, <a href="https://publications.waset.org/abstracts/search?q=Tae-Young%20Roh"> Tae-Young Roh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The gastrointestinal (GI) tract of most animals, including murine, is highly compartmentalized epithelia which also provide distinct different functions of its own tissue. Nevertheless, these epithelia share certain characteristics that enhance immune responses to infections and maintain the barrier function of the intestine. GI tract epithelia also undergo regeneration not only in homeostatic conditions but also in a response to the damage. A full turnover of the murine gastrointestinal epithelium occurs every 4-5 day, a process that is regulated and maintained by a minor population of Lgr5+ adult stem cell that commonly conserved in the bottom of crypts through GI tract. Maintenance of the stem cell is somehow regulated by epigenetic factors according to recent studies. Chromatin vacancy, remodelers, histone variants and histone modifiers could affect adult stem cell fate. In this study, Lgr5-EGFP reporter mouse was used to take advantage of exploring the epigenetic dynamics among Lgr5 positive mutual stem cell in GI tract. Cells were isolated by fluorescence-activated cell sorting (FACS), gene expression levels, chromatin accessibility changes and histone modifications were analyzed. Some notable chromatin structural related epigenetic variants were detected. To identify the overall cell-cell interaction inside the stem cell niche, an extensive genome-wide analysis should be also followed. According to the results, nevertheless, we expected a broader understanding of cellular niche maintaining stem cells and epigenetic barriers through conserved stem cell in GI tract. We expect that our study could provide more evidence of adult stem cell plasticity and more chances to understand each stem cell that takes parts in certain organs. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=adult%20stem%20cell" title="adult stem cell">adult stem cell</a>, <a href="https://publications.waset.org/abstracts/search?q=epigenetics" title=" epigenetics"> epigenetics</a>, <a href="https://publications.waset.org/abstracts/search?q=LGR5%20stem%20cell" title=" LGR5 stem cell"> LGR5 stem cell</a>, <a href="https://publications.waset.org/abstracts/search?q=gastrointestinal%20tract" title=" gastrointestinal tract"> gastrointestinal tract</a> </p> <a href="https://publications.waset.org/abstracts/84885/epigenomic-analysis-of-lgr5-stem-cells-in-gastrointestinal-tract" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/84885.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">229</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3628</span> Exploring the Relationship Between Helicobacter Pylori Infection and the Incidence of Bronchogenic Carcinoma</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jose%20R.%20Garcia">Jose R. Garcia</a>, <a href="https://publications.waset.org/abstracts/search?q=Lexi%20Frankel"> Lexi Frankel</a>, <a href="https://publications.waset.org/abstracts/search?q=Amalia%20Ardeljan"> Amalia Ardeljan</a>, <a href="https://publications.waset.org/abstracts/search?q=Sergio%20Medina"> Sergio Medina</a>, <a href="https://publications.waset.org/abstracts/search?q=Ali%20Yasback"> Ali Yasback</a>, <a href="https://publications.waset.org/abstracts/search?q=Omar%20Rashid"> Omar Rashid</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Helicobacter pylori (H. pylori) is a gram-negative, spiral-shaped bacterium that affects nearly half of the population worldwide and humans serve as the principal reservoir. Infection rates usually follow an inverse relationship with hygiene practices and are higher in developing countries than developed countries. Incidence varies significantly by geographic area, race, ethnicity, age, and socioeconomic status. H. pylori is primarily associated with conditions of the gastrointestinal tract such as atrophic gastritis and duodenal peptic ulcers. Infection is also associated with an increased risk of carcinogenesis as there is evidence to show that H. pylori infection may lead to gastric adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma. It is suggested that H. pylori infection may be considered as a systemic condition, leading to various novel associations with several different neoplasms such as colorectal cancer, pancreatic cancer, and lung cancer, although further research is needed. Emerging evidence suggests that H. pylori infection may offer protective effects against Mycobacterium tuberculosis as a result of non-specific induction of interferon- γ (IFN- γ). Similar methods of enhanced immunity may affect the development of bronchogenic carcinoma due to the antiproliferative, pro-apoptotic and cytostatic functions of IFN- γ. The purpose of this study was to evaluate the correlation between Helicobacter pylori infection and the incidence of bronchogenic carcinoma. Methods: The data was provided by a Health Insurance Portability and Accountability Act (HIPAA) compliant national database to evaluate the patients infected versus patients not infected with H. pylori using ICD-10 and ICD-9 codes. Access to the database was granted by the Holy Cross Health, Fort Lauderdale for the purpose of academic research. Standard statistical methods were used. Results:-Between January 2010 and December 2019, the query was analyzed and resulted in 163,224 in both the infected and control group, respectively. The two groups were matched by age range and CCI score. The incidence of bronchogenic carcinoma was 1.853% with 3,024 patients in the H. pylori group compared to 4.785% with 7,810 patients in the control group. The difference was statistically significant (p < 2.22x10-16) with an odds ratio of 0.367 (0.353 - 0.383) with a confidence interval of 95%. The two groups were matched by treatment and incidence of cancer, which resulted in a total of 101,739 patients analyzed after this match. The incidence of bronchogenic carcinoma was 1.929% with 1,962 patients in the H. pylori and treatment group compared to 4.618% with 4,698 patients in the control group with treatment. The difference was statistically significant (p < 2.22x10-16) with an odds ratio of 0.403 (0.383 - 0.425) with a confidence interval of 95%. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=bronchogenic%20carcinoma" title="bronchogenic carcinoma">bronchogenic carcinoma</a>, <a href="https://publications.waset.org/abstracts/search?q=helicobacter%20pylori" title=" helicobacter pylori"> helicobacter pylori</a>, <a href="https://publications.waset.org/abstracts/search?q=lung%20cancer" title=" lung cancer"> lung cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=pathogen-associated%20molecular%20patterns" title=" pathogen-associated molecular patterns"> pathogen-associated molecular patterns</a> </p> <a href="https://publications.waset.org/abstracts/140207/exploring-the-relationship-between-helicobacter-pylori-infection-and-the-incidence-of-bronchogenic-carcinoma" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/140207.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">183</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3627</span> Modelling and Optimization Analysis of Silicon/MgZnO-CBTSSe Tandem Solar Cells</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Vallisree%20Sivathanu">Vallisree Sivathanu</a>, <a href="https://publications.waset.org/abstracts/search?q=Kumaraswamidhas%20Lakshmi%20Annamalai"> Kumaraswamidhas Lakshmi Annamalai</a>, <a href="https://publications.waset.org/abstracts/search?q=Trupti%20Ranjan%20Lenka"> Trupti Ranjan Lenka</a> </p> <p class="card-text"><strong>Abstract:</strong></p> We report a tandem solar cell model with Silicon as the bottom cell absorber material and Cu₂BaSn(S, Se)₄(CBTSSe) as absorber material for the top cell. As a first step, the top and bottom cells were modelled and validated by comparison with the experiment. Once the individual cells are validated, then the tandem structure is modelled with Indium Tin Oxide(ITO) as conducting layer between the top and bottom cells. The tandem structure yielded better open circuit voltage and fill factor; however, the efficiency obtained is 7.01%. The top cell and the bottom cells are investigated with the help of electron-hole current density, photogeneration rate, and external quantum efficiency profiles. In order to minimize the various loss mechanisms in the tandem solar cell, the material parameters are optimized within experimentally achievable limits. Initially, the top cell optimization was carried out; then, the bottom cell is optimized for maximizing the light absorption, and upon minimizing the current and photon losses in the tandem structure, the maximum achievable efficiency is predicted to be 19.52%. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=CBTSSe" title="CBTSSe">CBTSSe</a>, <a href="https://publications.waset.org/abstracts/search?q=silicon" title=" silicon"> silicon</a>, <a href="https://publications.waset.org/abstracts/search?q=tandem" title=" tandem"> tandem</a>, <a href="https://publications.waset.org/abstracts/search?q=solar%20cell" title=" solar cell"> solar cell</a>, <a href="https://publications.waset.org/abstracts/search?q=device%20modeling" title=" device modeling"> device modeling</a>, <a href="https://publications.waset.org/abstracts/search?q=current%20losses" title=" current losses"> current losses</a>, <a href="https://publications.waset.org/abstracts/search?q=photon%20losses" title=" photon losses"> photon losses</a> </p> <a href="https://publications.waset.org/abstracts/177529/modelling-and-optimization-analysis-of-siliconmgzno-cbtsse-tandem-solar-cells" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/177529.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">117</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3626</span> An Improved Circulating Tumor Cells Analysis Method for Identifying Tumorous Blood Cells</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Salvador%20Garcia%20Bernal">Salvador Garcia Bernal</a>, <a href="https://publications.waset.org/abstracts/search?q=Chi%20Zheng"> Chi Zheng</a>, <a href="https://publications.waset.org/abstracts/search?q=Keqi%20Zhang"> Keqi Zhang</a>, <a href="https://publications.waset.org/abstracts/search?q=Lei%20Mao"> Lei Mao</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Circulating Tumor Cells (CTC) is used to detect tumoral cell metastases using blood samples of patients with cancer (lung, breast, etc.). Using an immunofluorescent method a three channel image (Red, Green, and Blue) are obtained. These set of images usually overpass the 11 x 30 M pixels in size. An aided tool is designed for imaging cell analysis to segmented and identify the tumorous cell based on the three markers signals. Our Method, it is cell-based (area and cell shape) considering each channel information and extracting and making decisions if it is a valid CTC. The system also gives information about number and size of tumor cells found in the sample. We present results in real-life samples achieving acceptable performance in identifying CTCs in short time. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Circulating%20Tumor%20Cells%20%28CTC%29" title="Circulating Tumor Cells (CTC)">Circulating Tumor Cells (CTC)</a>, <a href="https://publications.waset.org/abstracts/search?q=cell%20analysis" title=" cell analysis"> cell analysis</a>, <a href="https://publications.waset.org/abstracts/search?q=immunofluorescent" title=" immunofluorescent"> immunofluorescent</a>, <a href="https://publications.waset.org/abstracts/search?q=medical%20image%20analysis" title=" medical image analysis"> medical image analysis</a> </p> <a href="https://publications.waset.org/abstracts/81401/an-improved-circulating-tumor-cells-analysis-method-for-identifying-tumorous-blood-cells" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/81401.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">214</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3625</span> Antibacterial Evaluation, in Silico ADME and QSAR Studies of Some Benzimidazole Derivatives</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Strahinja%20Kova%C4%8Devi%C4%87">Strahinja Kovačević</a>, <a href="https://publications.waset.org/abstracts/search?q=Lidija%20Jevri%C4%87"> Lidija Jevrić</a>, <a href="https://publications.waset.org/abstracts/search?q=Milo%C5%A1%20Kuzmanovi%C4%87"> Miloš Kuzmanović</a>, <a href="https://publications.waset.org/abstracts/search?q=Sanja%20Podunavac-Kuzmanovi%C4%87"> Sanja Podunavac-Kuzmanović </a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this paper, various derivatives of benzimidazole have been evaluated against Gram-negative bacteria Escherichia coli. For all investigated compounds the minimum inhibitory concentration (MIC) was determined. Quantitative structure-activity relationships (QSAR) attempts to find consistent relationships between the variations in the values of molecular properties and the biological activity for a series of compounds so that these rules can be used to evaluate new chemical entities. The correlation between MIC and some absorption, distribution, metabolism and excretion (ADME) parameters was investigated, and the mathematical models for predicting the antibacterial activity of this class of compounds were developed. The quality of the multiple linear regression (MLR) models was validated by the leave-one-out (LOO) technique, as well as by the calculation of the statistical parameters for the developed models and the results are discussed on the basis of the statistical data. The results of this study indicate that ADME parameters have a significant effect on the antibacterial activity of this class of compounds. Principal component analysis (PCA) and agglomerative hierarchical clustering algorithms (HCA) confirmed that the investigated molecules can be classified into groups on the basis of the ADME parameters: Madin-Darby Canine Kidney cell permeability (MDCK), Plasma protein binding (PPB%), human intestinal absorption (HIA%) and human colon carcinoma cell permeability (Caco-2). <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=benzimidazoles" title="benzimidazoles">benzimidazoles</a>, <a href="https://publications.waset.org/abstracts/search?q=QSAR" title=" QSAR"> QSAR</a>, <a href="https://publications.waset.org/abstracts/search?q=ADME" title=" ADME"> ADME</a>, <a href="https://publications.waset.org/abstracts/search?q=in%20silico" title=" in silico"> in silico</a> </p> <a href="https://publications.waset.org/abstracts/18974/antibacterial-evaluation-in-silico-adme-and-qsar-studies-of-some-benzimidazole-derivatives" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/18974.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">375</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3624</span> An Empirical Dynamic Fuel Cell Model Used for Power System Verification in Aerospace</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Giuliano%20Raimondo">Giuliano Raimondo</a>, <a href="https://publications.waset.org/abstracts/search?q=J%C3%B6rg%20Wangemann"> Jörg Wangemann</a>, <a href="https://publications.waset.org/abstracts/search?q=Peer%20Drechsel"> Peer Drechsel</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In systems development involving Fuel Cells generators, it is important to have from an early stage of the project a dynamic model for the electrical behavior of the stack to be shared between involved development parties. It allows independent and early design and tests of fuel cell related power electronic. This paper presents an empirical Fuel Cell system model derived from characterization tests on a real system. Moreover, it is illustrated how the obtained model is used to build and validate a real-time Fuel Cell system emulator which is used for aerospace electrical integration testing activities. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=fuel%20cell" title="fuel cell">fuel cell</a>, <a href="https://publications.waset.org/abstracts/search?q=modelling" title=" modelling"> modelling</a>, <a href="https://publications.waset.org/abstracts/search?q=real%20time%20emulation" title=" real time emulation"> real time emulation</a>, <a href="https://publications.waset.org/abstracts/search?q=testing" title=" testing"> testing</a> </p> <a href="https://publications.waset.org/abstracts/57838/an-empirical-dynamic-fuel-cell-model-used-for-power-system-verification-in-aerospace" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/57838.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">336</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3623</span> VHL, PBRM1, and SETD2 Genes in Kidney Cancer: A Molecular Investigation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Rozhgar%20A.%20Khailany">Rozhgar A. Khailany</a>, <a href="https://publications.waset.org/abstracts/search?q=Mehri%20Igci"> Mehri Igci</a>, <a href="https://publications.waset.org/abstracts/search?q=Emine%20Bayraktar"> Emine Bayraktar</a>, <a href="https://publications.waset.org/abstracts/search?q=Sakip%20Erturhan"> Sakip Erturhan</a>, <a href="https://publications.waset.org/abstracts/search?q=Metin%20Karakok"> Metin Karakok</a>, <a href="https://publications.waset.org/abstracts/search?q=Ahmet%20Arslan"> Ahmet Arslan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Kidney cancer is the most lethal urological cancer accounting for 3% of adult malignancies. VHL, a tumor-suppressor gene, is best known to be associated with renal cell carcinoma (RCC). The VHL functions as negative regulator of hypoxia inducible factors. Recent sequencing efforts have identified several novel frequent mutations of histone modifying and chromatin remodeling genes in ccRCC (clear cell RCC) including PBRM1 and SETD2. The PBRM1 gene encodes the BAF180 protein, which involved in transcriptional activation and repression of selected genes. SETD2 encodes a histone methyltransferase, which may play a role in suppressing tumor development. In this study, RNAs of 30 paired tumor and normal samples that were grouped according to the types of kidney cancer and clinical characteristics of patients, including gender and average age were examined by RT-PCR, SSCP and sequencing techniques. VHL, PBRM1 and SETD2 expressions were relatively down-regulated. However, statistically no significance was found (Wilcoxon signed rank test, p > 0.05). Interestingly, no mutation was observed on the contrary of previous studies. Understanding the molecular mechanisms involved in the pathogenesis of RCC has aided the development of molecular-targeted drugs for kidney cancer. Further analysis is required to identify the responsible genes rather than VHL, PBRM1 and SETD2 in kidney cancer. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=kidney%20cancer" title="kidney cancer">kidney cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20biomarker" title=" molecular biomarker"> molecular biomarker</a>, <a href="https://publications.waset.org/abstracts/search?q=expression%20analysis" title=" expression analysis"> expression analysis</a>, <a href="https://publications.waset.org/abstracts/search?q=mutation%20screening" title=" mutation screening"> mutation screening</a> </p> <a href="https://publications.waset.org/abstracts/21021/vhl-pbrm1-and-setd2-genes-in-kidney-cancer-a-molecular-investigation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/21021.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">459</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3622</span> In vitro Cytotoxicity Study on Silver Powders Synthesized via Different Routes</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Otilia%20Ruxandra%20Vasile">Otilia Ruxandra Vasile</a>, <a href="https://publications.waset.org/abstracts/search?q=Ecaterina%20Andronescu"> Ecaterina Andronescu</a>, <a href="https://publications.waset.org/abstracts/search?q=Cristina%20Daniela%20Ghitulica"> Cristina Daniela Ghitulica</a>, <a href="https://publications.waset.org/abstracts/search?q=Bogdan%20Stefan%20Vasile"> Bogdan Stefan Vasile</a>, <a href="https://publications.waset.org/abstracts/search?q=Roxana%20Trusca"> Roxana Trusca</a>, <a href="https://publications.waset.org/abstracts/search?q=Eugeniu%20Vasile"> Eugeniu Vasile</a>, <a href="https://publications.waset.org/abstracts/search?q=Alina%20Maria%20Holban"> Alina Maria Holban</a>, <a href="https://publications.waset.org/abstracts/search?q=Carmen%20Mariana%20Chifiriuc"> Carmen Mariana Chifiriuc</a>, <a href="https://publications.waset.org/abstracts/search?q=Florin%20Iordache"> Florin Iordache</a>, <a href="https://publications.waset.org/abstracts/search?q=Horia%20Maniu"> Horia Maniu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Engineered powders offer great promise in several applications, but little information is known about cytotoxicity effects. The aim of the current study was the synthesis and cytotoxicity examination of silver powders using pyrosol method at temperatures of 600°C, 650°C and 700°C, respectively sol-gel method and calcinations at 500°C, 600°C, 700°C and 800°C. We have chosen to synthesize and examine silver particles cytotoxicity due to its use in biological applications. The synthesized Ag powders were characterized from the structural, compositional and morphological point of view by using XRD, SEM, and TEM with SAED. In order to determine the influence of the synthesis route on Ag particles cytotoxicity, different sizes of micro and nanosilver synthesized powders were evaluated for their potential toxicity. For the study of their cytotoxicity, cell cycle and apoptosis have been done analysis through flow cytometry on human colon carcinoma cells and mesenchymal stem cells and through the MTT assay, while the viability and the morphological changes of the cells have been evaluated by using cloning studies. The results showed that the synthesized silver nanoparticles have displayed significant cytotoxicity effects on cell cultures. Our synthesized silver powders were found to present toxicity in a synthesis route and time-dependent manners for pyrosol synthesized nanoparticles; whereas a lower cytotoxicity has been measured after cells were treated with silver nanoparticles synthesized through sol-gel method. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ag" title="Ag">Ag</a>, <a href="https://publications.waset.org/abstracts/search?q=cytotoxicity" title=" cytotoxicity"> cytotoxicity</a>, <a href="https://publications.waset.org/abstracts/search?q=pyrosol%20method" title=" pyrosol method"> pyrosol method</a>, <a href="https://publications.waset.org/abstracts/search?q=sol-gel%20method" title=" sol-gel method"> sol-gel method</a> </p> <a href="https://publications.waset.org/abstracts/25784/in-vitro-cytotoxicity-study-on-silver-powders-synthesized-via-different-routes" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/25784.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">594</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3621</span> An Audit of the Process of Care in Surveillance Services for Children with Sickle Cell Disease in Wales</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Charlie%20Jeffkins">Charlie Jeffkins</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Sickle cell disease is a serious life-limiting condition which can reduce the quality of life for many patients. Public Health England (PHE), in partnership with the Sickle Cell Society (SCS), has created guidelines to prevent severe complications from sickle cell disease. Data was collected from Children’s Hospital for Wales between 15/03/21-26/03/21. Methods: A manual search of patient records for children under the care of Rocket Ward and a key term search of online records was used. Results: Penicillin prophylaxis was given at 90 days for 89%, 77% of TCDs scans were done at 2-3 years, and 72% have had a scan in the last year. 53% of patients have had discussions about hydroxycarbamide, whilst 65% have started it. PPV vaccination was documented for 19%. Conclusion: Overall, none of the four standards were reached; however, TCD uptake has improved. There is a need for better documentation of treatment and annual re-audits. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=paediatric" title="paediatric">paediatric</a>, <a href="https://publications.waset.org/abstracts/search?q=haematology" title=" haematology"> haematology</a>, <a href="https://publications.waset.org/abstracts/search?q=sickle%20cell" title=" sickle cell"> sickle cell</a>, <a href="https://publications.waset.org/abstracts/search?q=audit" title=" audit"> audit</a> </p> <a href="https://publications.waset.org/abstracts/142056/an-audit-of-the-process-of-care-in-surveillance-services-for-children-with-sickle-cell-disease-in-wales" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/142056.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">221</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3620</span> Cytogenetic Characterization of the VERO Cell Line Based on Comparisons with the Subline; Implication for Authorization and Quality Control of Animal Cell Lines</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Fumio%20Kasai">Fumio Kasai</a>, <a href="https://publications.waset.org/abstracts/search?q=Noriko%20Hirayama"> Noriko Hirayama</a>, <a href="https://publications.waset.org/abstracts/search?q=Jorge%20Pereira"> Jorge Pereira</a>, <a href="https://publications.waset.org/abstracts/search?q=Azusa%20Ohtani"> Azusa Ohtani</a>, <a href="https://publications.waset.org/abstracts/search?q=Masashi%20Iemura"> Masashi Iemura</a>, <a href="https://publications.waset.org/abstracts/search?q=Malcolm%20A.%20Ferguson%20Smith"> Malcolm A. Ferguson Smith</a>, <a href="https://publications.waset.org/abstracts/search?q=Arihiro%20Kohara"> Arihiro Kohara</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The VERO cell line was established in 1962 from normal tissue of an African green monkey, Chlorocebus aethiops (2n=60), and has been commonly used worldwide for screening for toxins or as a cell substrate for the production of viral vaccines. The VERO genome was sequenced in 2014; however, its cytogenetic features have not been fully characterized as it contains several chromosome abnormalities and different karyotypes coexist in the cell line. In this study, the VERO cell line (JCRB0111) was compared with one of the sublines. In contrast to 59 chromosomes as the modal chromosome number in the VERO cell line, the subline had two peaks of 56 and 58 chromosomes. M-FISH analysis using human probes revealed that the VERO cell line was characterized by a translocation t(2;25) found in all metaphases, which was absent in the subline. Different abnormalities detected only in the subline show that the cell line is heterogeneous, indicating that the subline has the potential to change its genomic characteristics during cell culture. The various alterations in the two independent lineages suggest that genomic changes in both VERO cells can be accounted for by progressive rearrangements during their evolution in culture. Both t(5;X) and t(8;14) observed in all metaphases of the two cell lines might have a key role in VERO cells and could be used as genetic markers to identify VERO cells. The flow karyotype shows distinct differences from normal. Further analysis of sorted abnormal chromosomes may uncover other characteristics of VERO cells. Because of the absence of STR data, cytogenetic data are important in characterizing animal cell lines and can be an indicator of their quality control. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=VERO" title="VERO">VERO</a>, <a href="https://publications.waset.org/abstracts/search?q=cell%20culture%20passage" title=" cell culture passage"> cell culture passage</a>, <a href="https://publications.waset.org/abstracts/search?q=chromosome%20rearrangement" title=" chromosome rearrangement"> chromosome rearrangement</a>, <a href="https://publications.waset.org/abstracts/search?q=heterogeneous%20cells" title=" heterogeneous cells"> heterogeneous cells</a> </p> <a href="https://publications.waset.org/abstracts/32913/cytogenetic-characterization-of-the-vero-cell-line-based-on-comparisons-with-the-subline-implication-for-authorization-and-quality-control-of-animal-cell-lines" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/32913.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">416</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3619</span> Electrochemical Studies of Si, Si-Ge- and Ge-Air Batteries</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=R.%20C.%20Sharma">R. C. Sharma</a>, <a href="https://publications.waset.org/abstracts/search?q=Rishabh%20Bansal"> Rishabh Bansal</a>, <a href="https://publications.waset.org/abstracts/search?q=Prajwal%20Menon"> Prajwal Menon</a>, <a href="https://publications.waset.org/abstracts/search?q=Manoj%20K.%20Sharma"> Manoj K. Sharma</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Silicon-air battery is highly promising for electric vehicles due to its high theoretical energy density (8470 Whkg⁻¹) and its discharge products are non-toxic. For the first time, pure silicon and germanium powders are used as anode material. Nickel wire meshes embedded with charcoal and manganese dioxide powder as cathode and concentrated potassium hydroxide is used as electrolyte. Voltage-time curves have been presented in this study for pure silicon and germanium powder and 5% and 10% germanium with silicon powder. Silicon powder cell assembly gives a stable voltage of 0.88 V for ~20 minutes while Si-Ge provides cell voltage of 0.80-0.76 V for ~10-12 minutes, and pure germanium cell provides cell voltage 0.80-0.76 V for ~30 minutes. The cell voltage is higher for concentrated (10%) sodium hydroxide solution (1.08 V) and it is stable for ~40 minutes. A sharp decrease in cell voltage beyond 40 min may be due to rapid corrosion. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Silicon-air%20battery" title="Silicon-air battery">Silicon-air battery</a>, <a href="https://publications.waset.org/abstracts/search?q=Germanium-air%20battery" title=" Germanium-air battery"> Germanium-air battery</a>, <a href="https://publications.waset.org/abstracts/search?q=voltage-time%20curve" title=" voltage-time curve"> voltage-time curve</a>, <a href="https://publications.waset.org/abstracts/search?q=open%20circuit%20voltage" title=" open circuit voltage"> open circuit voltage</a>, <a href="https://publications.waset.org/abstracts/search?q=Anodic%20corrosion" title=" Anodic corrosion"> Anodic corrosion</a> </p> <a href="https://publications.waset.org/abstracts/138312/electrochemical-studies-of-si-si-ge-and-ge-air-batteries" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/138312.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">238</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3618</span> Activation of Caspase 3 by Terpenoids and Flavonoids in Cancer Cell Lines</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nusrat%20Masood">Nusrat Masood</a>, <a href="https://publications.waset.org/abstracts/search?q=Vijaya%20Dubey"> Vijaya Dubey</a>, <a href="https://publications.waset.org/abstracts/search?q=Suaib%20Luqman"> Suaib Luqman</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Caspase 3, a member of cysteine-aspartic acid protease family, is an imperative indicator for cell death particularly when substantiating apoptosis. Thus, caspase 3 is an interesting target for the discovery and development of anticancer agent. We adopted a four level assessment of both terpenoids and flavonoids and thus experimentally performed the enzymatic assay in cell free system as well as in cancer cell line which was validated through real time expression and molecular interaction studies. A significant difference was observed with both the class of natural products indicating terpenoids as better activators of caspase 3 compared to flavonoids both in the cell free system as well as in cell lines. The expression analysis, activation constant and binding energy also correlate well with the enzyme activity. Overall, terpenoids had an unswerving effect on caspase 3 in all the tested system while flavonoids indirectly affect enzyme activity. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Caspase%203" title="Caspase 3">Caspase 3</a>, <a href="https://publications.waset.org/abstracts/search?q=terpenoids" title=" terpenoids"> terpenoids</a>, <a href="https://publications.waset.org/abstracts/search?q=flavonoids" title=" flavonoids"> flavonoids</a>, <a href="https://publications.waset.org/abstracts/search?q=activation%20constant" title=" activation constant"> activation constant</a>, <a href="https://publications.waset.org/abstracts/search?q=binding%20energy" title=" binding energy"> binding energy</a> </p> <a href="https://publications.waset.org/abstracts/72938/activation-of-caspase-3-by-terpenoids-and-flavonoids-in-cancer-cell-lines" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/72938.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">238</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3617</span> Investigating the Effect of Adding the Window Layer and the Back Surface Field Layer of InₓGa₍₁₋ₓ₎P Material to GaAs Single Junction Solar Cell</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ahmad%20Taghinia">Ahmad Taghinia</a>, <a href="https://publications.waset.org/abstracts/search?q=Negar%20Gholamishaker"> Negar Gholamishaker</a> </p> <p class="card-text"><strong>Abstract:</strong></p> GaAs (gallium arsenide) solar cells have gained significant attention for their use in space applications. These solar cells have the potential for efficient energy conversion and are being explored as potential power sources for electronic devices, satellites, and telecommunication equipment. In this study, the aim is to investigate the effect of adding a window layer and a back surface field (BSF) layer made of InₓGa₍₁₋ₓ₎P material to a GaAs single junction solar cell. In this paper, we first obtain the important electrical parameters of a single-junction GaAs solar cell by utilizing a two-dimensional simulator software for virtual investigation of the solar cell; then, we analyze the impact of adding a window layer and a back surface field layer made of InₓGa₍₁₋ₓ₎P on the solar cell. The results show that the incorporation of these layers led to enhancements in Jsc, Voc, FF, and the overall efficiency of the solar cell. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=back%20surface%20field%20layer" title="back surface field layer">back surface field layer</a>, <a href="https://publications.waset.org/abstracts/search?q=solar%20cell" title=" solar cell"> solar cell</a>, <a href="https://publications.waset.org/abstracts/search?q=GaAs" title=" GaAs"> GaAs</a>, <a href="https://publications.waset.org/abstracts/search?q=In%E2%82%93Ga%E2%82%8D%E2%82%81%E2%82%8B%E2%82%93%E2%82%8EP" title=" InₓGa₍₁₋ₓ₎P"> InₓGa₍₁₋ₓ₎P</a>, <a href="https://publications.waset.org/abstracts/search?q=window%20layer" title=" window layer"> window layer</a> </p> <a href="https://publications.waset.org/abstracts/170469/investigating-the-effect-of-adding-the-window-layer-and-the-back-surface-field-layer-of-inga1p-material-to-gaas-single-junction-solar-cell" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/170469.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">76</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3616</span> Power and Efficiency of Photovoltaic Module: Effect of Cell Temperature</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=R.%20Nasrin">R. Nasrin</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Ferdows"> M. Ferdows</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Among the renewable energy sources, photovoltaic (PV) is a high potential, effective, and sustainable system. Irradiation intensity from 200 W/m2 to 1000 W/m2 has been considered to observe the performance of PV module. Generally, this module converts only about 15% - 20% of incident irradiation into electrical energy and the rest part is converted into heat energy. Finite element method has been used to solve the problem numerically. Simulation has been performed by considering the ambient temperature 30°C. Higher irradiation increase solar cell temperature and electrical power. The electrical efficiency of PV module decreases with the variation of solar radiation. The efficiency of PV module can be increased if cell temperature is reduced. Thus the effect of irradiation is significant to enhance the efficiency of PV module if the solar cell temperature is kept at a certain level. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=PV%20module" title="PV module">PV module</a>, <a href="https://publications.waset.org/abstracts/search?q=solar%20radiation" title=" solar radiation"> solar radiation</a>, <a href="https://publications.waset.org/abstracts/search?q=efficiency" title=" efficiency"> efficiency</a>, <a href="https://publications.waset.org/abstracts/search?q=cell%20temperature" title=" cell temperature"> cell temperature</a> </p> <a href="https://publications.waset.org/abstracts/82035/power-and-efficiency-of-photovoltaic-module-effect-of-cell-temperature" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/82035.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">361</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3615</span> Hsa-miR-139-5p Acts as a Tumor Suppressor by Targeting C-Met in Non-Small Cell Lung Cancer</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Chengcao%20Sun">Chengcao Sun</a>, <a href="https://publications.waset.org/abstracts/search?q=Shujun%20Li"> Shujun Li</a>, <a href="https://publications.waset.org/abstracts/search?q=Cuili%20Yang"> Cuili Yang</a>, <a href="https://publications.waset.org/abstracts/search?q=Yongyong%20Xi"> Yongyong Xi</a>, <a href="https://publications.waset.org/abstracts/search?q=Liang%20Wang"> Liang Wang</a>, <a href="https://publications.waset.org/abstracts/search?q=Feng%20Zhang"> Feng Zhang</a>, <a href="https://publications.waset.org/abstracts/search?q=Dejia%20Li"> Dejia Li</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Hsa-miRNA-139-5p (miR-139-5p) has recently been discovered having anticancer efficacy in different organs. However, the role of miR-139-5p on lung cancer is still ambiguous. In this study, we investigated the role of miR-139-5p on development of lung cancer. Results indicated miR-139-5p was significantly down-regulated in primary tumor tissues and very low levels were found in a non-small cell lung cancer (NSCLC) cell lines. Ectopic expression of miR-139-5p in NSCLC cell lines significantly suppressed cell growth through inhibition of cyclin D1 and up-regulation of p57(Kip2). In addition, miR-139-5p induced apoptosis, as indicated by up-regulation of key apoptosis gene cleaved caspase-3, and down-regulation of anti-apoptosis gene Bcl2. Moreover, miR-139-5p inhibited cellular metastasis through inhibition of matrix metalloproteinases (MMP)-7 and MMP-9. Further, oncogene c-Met was revealed to be a putative target of miR-139-5p, which was inversely correlated with miR-139-5p expression. Taken together, our results demonstrated that miR-139-5p plays a pivotal role in lung cancer through inhibiting cell proliferation, metastasis, and promoting apoptosis by targeting oncogenic c-Met. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=hsa-miRNA-139-5p%20%28miR-139-5p%29" title="hsa-miRNA-139-5p (miR-139-5p)">hsa-miRNA-139-5p (miR-139-5p)</a>, <a href="https://publications.waset.org/abstracts/search?q=c-Met" title=" c-Met"> c-Met</a>, <a href="https://publications.waset.org/abstracts/search?q=non-small%20cell%20lung%20cancer%20%28NSCLC%29" title=" non-small cell lung cancer (NSCLC)"> non-small cell lung cancer (NSCLC)</a>, <a href="https://publications.waset.org/abstracts/search?q=proliferation" title=" proliferation"> proliferation</a>, <a href="https://publications.waset.org/abstracts/search?q=apoptosis" title=" apoptosis"> apoptosis</a> </p> <a href="https://publications.waset.org/abstracts/41708/hsa-mir-139-5p-acts-as-a-tumor-suppressor-by-targeting-c-met-in-non-small-cell-lung-cancer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/41708.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">343</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3614</span> Comparison of 18F-FDG and 11C-Methionine PET-CT for Assessment of Response to Neoadjuvant Chemotherapy in Locally Advanced Breast Carcinoma</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sonia%20Mahajan%20Dinesh">Sonia Mahajan Dinesh</a>, <a href="https://publications.waset.org/abstracts/search?q=Anant%20Dinesh"> Anant Dinesh</a>, <a href="https://publications.waset.org/abstracts/search?q=Madhavi%20Tripathi"> Madhavi Tripathi</a>, <a href="https://publications.waset.org/abstracts/search?q=Vinod%20Kumar%20Ramteke"> Vinod Kumar Ramteke</a>, <a href="https://publications.waset.org/abstracts/search?q=Rajnish%20Sharma"> Rajnish Sharma</a>, <a href="https://publications.waset.org/abstracts/search?q=Anupam%20Mondal"> Anupam Mondal</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Neo-adjuvant chemotherapy plays an important role in treatment of breast cancer by decreasing the tumour load and it offers an opportunity to evaluate response of primary tumour to chemotherapy. Standard anatomical imaging modalities are unable to accurately reflect the response to chemotherapy until several cycles of drug treatment have been completed. Metabolic imaging using tracers like 18F-fluorodeoxyglucose (FDG) as a marker of glucose metabolism or amino acid tracers like L-methyl-11C methionine (MET) have potential role for the measurement of treatment response. In this study, our objective was to compare these two PET tracers for assessment of response to neoadjuvant chemotherapy, in locally advanced breast carcinoma. Methods: In our prospective study, 20 female patients with histology proven locally advanced breast carcinoma underwent PET-CT imaging using FDG and MET before and after three cycles of neoadjuvant chemotherapy (CAF regimen). Thereafter, all patients were taken for MRM and the resected specimen was sent for histo-pathological analysis. Tumour response to the neoadjuvant chemotherapy was evaluated by PET-CT imaging using PERCIST criteria and correlated with histological results. Responses calculated were compared for statistical significance using paired t- test. Results: Mean SUVmax for primary lesion in FDG PET and MET PET was 15.88±11.12 and 5.01±2.14 respectively (p<0.001) and for axillary lymph nodes was 7.61±7.31 and 2.75±2.27 respectively (p=0.001). Statistically significant response in primary tumour and axilla was noted on both FDG and MET PET after three cycles of NAC. Complete response in primary tumour was seen in only 1 patient in FDG and 7 patients in MET PET (p=0.001) whereas there was no histological complete resolution of tumor in any patient. Response to therapy in axillary nodes noted on both PET scans were similar (p=0.45) and correlated well with histological findings. Conclusions: For the primary breast tumour, FDG PET has a higher sensitivity and accuracy than MET PET and for axilla both have comparable sensitivity and specificity. FDG PET shows higher target to background ratios so response is better predicted for primary breast tumour and axilla. Also, FDG-PET is widely available and has the advantage of a whole body evaluation in one study. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=11C-methionine" title="11C-methionine">11C-methionine</a>, <a href="https://publications.waset.org/abstracts/search?q=18F-FDG" title=" 18F-FDG"> 18F-FDG</a>, <a href="https://publications.waset.org/abstracts/search?q=breast%20carcinoma" title=" breast carcinoma"> breast carcinoma</a>, <a href="https://publications.waset.org/abstracts/search?q=neoadjuvant%20chemotherapy" title=" neoadjuvant chemotherapy"> neoadjuvant chemotherapy</a> </p> <a href="https://publications.waset.org/abstracts/1987/comparison-of-18f-fdg-and-11c-methionine-pet-ct-for-assessment-of-response-to-neoadjuvant-chemotherapy-in-locally-advanced-breast-carcinoma" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/1987.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">510</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3613</span> Immunomodulatory Role of Heat Killed Mycobacterium indicus pranii against Cervical Cancer </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Priyanka%20Bhowmik">Priyanka Bhowmik</a>, <a href="https://publications.waset.org/abstracts/search?q=Subrata%20Majumdar"> Subrata Majumdar</a>, <a href="https://publications.waset.org/abstracts/search?q=Debprasad%20Chattopadhyay"> Debprasad Chattopadhyay</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Cervical cancer is the third major cause of cancer in women and the second most frequent cause of cancer related deaths causing 300,000 deaths annually worldwide. Evasion of immune response by Human Papilloma Virus (HPV), the key contributing factor behind cancer and pre-cancerous lesions of the uterine cervix, makes immunotherapy a necessity to treat this disease. Objective: A Heat killed fraction of Mycobacterium indicus pranii (MIP), a non-pathogenic Mycobacterium has been shown to exhibit cytotoxic effects on different cancer cells, including human cervical carcinoma cell line HeLa. However, the underlying mechanisms remain unknown. The aim of this study is to decipher the mechanism of MIP induced HeLa cell death. Methods: The cytotoxicity of Mycobacterium indicus pranii against HeLa cells was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Apoptosis was detected by annexin V and Propidium iodide (PI) staining. The assessment of reactive oxygen species (ROS) generation and cell cycle analysis were measured by flow cytometry. The expression of apoptosis associated genes was analyzed by real time PCR. Result: MIP could inhibit the proliferation of HeLa cell in a time and dose dependent manner but caused minor damage to normal cells. The induction of apoptosis was confirmed by the cell surface presentation of phosphatidyl serine, DNA fragmentation, and mitochondrial damage. MIP caused very early (as early as 30 minutes) transcriptional activation of p53, followed by a higher activation (32 fold) at 24 hours suggesting prime importance of p53 in MIP-induced apoptosis in HeLa cell. The up regulation of p53 dependent pro-apoptotic genes Bax, Bak, PUMA, and Noxa followed a lag phase that was required for the transcriptional p53 program. MIP also caused the transcriptional up regulation of Toll like receptor 2 and 4 after 30 minutes of MIP treatment suggesting recognition of MIP by toll like receptors. Moreover, MIP caused the inhibition of expression of HPV anti apoptotic gene E6, which is known to interfere with p53/PUMA/Bax apoptotic cascade. This inhibition might have played a role in transcriptional up regulation of PUMA and subsequently apoptosis. ROS was generated transiently which was concomitant with the highest transcription activation of p53 suggesting a plausible feedback loop network of p53 and ROS in the apoptosis of HeLa cells. Scavenger of ROS, such as N-acetyl-L-cysteine, decreased apoptosis suggesting ROS is an important effector of MIP induced apoptosis. Conclusion: Taken together, MIP possesses full potential to be a novel therapeutic agent in the clinical treatment of cervical cancer. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cancer" title="cancer">cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=mycobacterium" title=" mycobacterium"> mycobacterium</a>, <a href="https://publications.waset.org/abstracts/search?q=immunity" title=" immunity"> immunity</a>, <a href="https://publications.waset.org/abstracts/search?q=immunotherapy." title=" immunotherapy."> immunotherapy.</a> </p> <a href="https://publications.waset.org/abstracts/80727/immunomodulatory-role-of-heat-killed-mycobacterium-indicus-pranii-against-cervical-cancer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/80727.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">249</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3612</span> Design of a Compact Herriott Cell for Heat Flux Measurement Applications</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=R.%20G.%20Ram%C3%ADrez-Chavarr%C3%ADa">R. G. Ramírez-Chavarría</a>, <a href="https://publications.waset.org/abstracts/search?q=C.%20S%C3%A1nchez-P%C3%A9rez"> C. Sánchez-Pérez</a>, <a href="https://publications.waset.org/abstracts/search?q=V.%20Argueta-D%C3%ADaz"> V. Argueta-Díaz</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this paper we present the design of an optical device based on a Herriott multi-pass cell fabricated on a small sized acrylic slab for heat flux measurements using the deflection of a laser beam propagating inside the cell. The beam deflection is produced by the heat flux conducted to the acrylic slab due to a gradient in the refractive index. The use of a long path cell as the sensitive element in this measurement device, gives the possibility of high sensitivity within a small size device. We present the optical design as well as some experimental results in order to validate the device’s operation principle. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=heat%20flux" title="heat flux">heat flux</a>, <a href="https://publications.waset.org/abstracts/search?q=Herriott%20cell" title=" Herriott cell"> Herriott cell</a>, <a href="https://publications.waset.org/abstracts/search?q=optical%20beam%20deflection" title=" optical beam deflection"> optical beam deflection</a>, <a href="https://publications.waset.org/abstracts/search?q=thermal%20conductivity" title=" thermal conductivity"> thermal conductivity</a> </p> <a href="https://publications.waset.org/abstracts/31146/design-of-a-compact-herriott-cell-for-heat-flux-measurement-applications" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/31146.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">657</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3611</span> Bacterial Diversity in Vaginal Microbiota in Patients with Different Levels of Cervical Lesions Related to Human Papillomavirus Infection</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Michelle%20S.%20Pereira">Michelle S. Pereira</a>, <a href="https://publications.waset.org/abstracts/search?q=Analice%20C.%20Azevedo"> Analice C. Azevedo</a>, <a href="https://publications.waset.org/abstracts/search?q=Julliane%20D.%20Medeiros"> Julliane D. Medeiros</a>, <a href="https://publications.waset.org/abstracts/search?q=Ana%20Claudia%20S.%20Martins"> Ana Claudia S. Martins</a>, <a href="https://publications.waset.org/abstracts/search?q=Didier%20S.%20Castellano-Filho"> Didier S. Castellano-Filho</a>, <a href="https://publications.waset.org/abstracts/search?q=Claudio%20G.%20Diniz"> Claudio G. Diniz</a>, <a href="https://publications.waset.org/abstracts/search?q=Vania%20L.%20Silva"> Vania L. Silva</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Vaginal microbiota is a complex ecosystem, composed by aerobic and anaerobic bacteria, living in a dynamic equilibrium. Lactobacillus spp. are predominant in vaginal ecosystem, and factors such as immunity and hormonal variations may lead to disruptions, resulting in proliferation of opportunistic pathogens. Bacterial vaginosis (BV) is a polymicrobial syndrome, caused by an increasing of anaerobic bacteria replacing Lactobacillus spp. Microorganisms such as Gardnerella vaginalis, Mycoplasma hominis, Mobiluncus spp., and Atopobium vaginae can be found in BV, which may also be associated to other infections such as by Human Papillomavirus (HPV). HPV is highly prevalent in sexually active women, and is considered a risk factor for development of cervical cancer. As long as few data is available on vaginal microbiota of women with HPV-associated cervical lesions, our objectives were to evaluate the diversity in vaginal ecosystem in these women. To all patients, clinical and socio-demographic data were collected after gynecological examination. This study was approved by the Ethics Committee from Federal University of Juiz de Fora, Minas Gerais, Brazil. Vaginal secretion and cervical scraping were collected. Gram-stained smears were evaluated to establish Nugent score for BV determination. Viral and bacterial DNA obtained was used as template for HPV genotyping (PCR) and bacterial fingerprint (REP-PCR). In total 31 patients were included (mean age 35 and 93.6% sexually active). The Nugent score showed that 38.7% were BV. From the medical records, Pap smear tests showed that 32.3% had low grade squamous epithelial lesion (LSIL), 29% had high grade squamous epithelial lesion (HSIL), 25.8% had atypical squamous cells of undetermined significance (ASC-US) and 12.9% with atypical squamous cells that would not exclude high-grade lesion (ASC-H). All participants were HPV+. HPV-16 was the most frequent (87.1%), followed by HPV-18 (61.3%). HPV-31, HPV-52 and HPV-58 were also detected. Coinfection HPV-16/HPV-18 was observed in 75%. In the 18-30 age group, HPV-16 was detected in 40%, and HPV-16/HPV-18 coinfection in 35%. HPV-16 was associated to 30% of ASC-H and 20% of HSIL patients. BV was observed in 50% of HPV-16+ participants and in 45% of HPV-16/HPV-18+. Fingerprints of bacterial communities showed clusters with low similarity suggesting high heterogeneity in vaginal microbiota within the sampled group. Overall, the data is worrisome once cervical-cancer highly risk-associated HPV-types were identified. The high microbial diversity observed may be related to the different levels of cellular lesions, and different physiological conditions of the participants (age, social behavior, education). Further prospective studies are needed to better address correlations and BV and microbial imbalance in vaginal ecosystems which would be related to the different cellular lesions in women with HPV infections. Supported by FAPEMIG, CNPq, CAPES, PPGCBIO/UFJF. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=human%20papillomavirus" title="human papillomavirus">human papillomavirus</a>, <a href="https://publications.waset.org/abstracts/search?q=bacterial%20vaginosis" title=" bacterial vaginosis"> bacterial vaginosis</a>, <a href="https://publications.waset.org/abstracts/search?q=bacterial%20diversity" title=" bacterial diversity"> bacterial diversity</a>, <a href="https://publications.waset.org/abstracts/search?q=cervical%20cancer" title=" cervical cancer"> cervical cancer</a> </p> <a href="https://publications.waset.org/abstracts/80784/bacterial-diversity-in-vaginal-microbiota-in-patients-with-different-levels-of-cervical-lesions-related-to-human-papillomavirus-infection" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/80784.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">195</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3610</span> Immunomodulatory Effects of Multipotent Mesenchymal Stromal Cells on T-Cell Populations at Tissue-Related Oxygen Level</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=A.%20N.%20Gornostaeva">A. N. Gornostaeva</a>, <a href="https://publications.waset.org/abstracts/search?q=P.%20I.%20Bobyleva"> P. I. Bobyleva</a>, <a href="https://publications.waset.org/abstracts/search?q=E.%20R.%20Andreeva"> E. R. Andreeva</a>, <a href="https://publications.waset.org/abstracts/search?q=L.%20B.%20Buravkova"> L. B. Buravkova</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Multipotent mesenchymal stromal cells (MSCs) possess immunomodulatory properties. The effect of MSCs on the crucial cellular immunity compartment – T-cells is of a special interest. It is known that MSC tissue niche and expected milieu of their interaction with T- cells are characterized by low oxygen concentration, whereas the in vitro experiments usually are carried out at a much higher ambient oxygen (20%). We firstly evaluated immunomodulatory effects of MSCs on T-cells at tissue-related oxygen (5%) after interaction implied cell-to-cell contacts and paracrine factors only. It turned out that MSCs under reduced oxygen can effectively suppress the activation and proliferation of PHA-stimulated T-cells and can provoke decrease in the production of proinflammatory and increase in anti-inflammatory cytokines. In hypoxia some effects were amplified (inhibition of proliferation, anti-inflammatory cytokine profile shift). This impact was more evident after direct cell-to-cell interaction; lack of intercellular contacts could revoke the potentiating effect of hypoxia. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=MSCs" title="MSCs">MSCs</a>, <a href="https://publications.waset.org/abstracts/search?q=T-cells" title=" T-cells"> T-cells</a>, <a href="https://publications.waset.org/abstracts/search?q=activation" title=" activation"> activation</a>, <a href="https://publications.waset.org/abstracts/search?q=low%20oxygen" title=" low oxygen"> low oxygen</a>, <a href="https://publications.waset.org/abstracts/search?q=cell-to-cell%20interaction" title=" cell-to-cell interaction"> cell-to-cell interaction</a>, <a href="https://publications.waset.org/abstracts/search?q=immunosuppression" title=" immunosuppression "> immunosuppression </a> </p> <a href="https://publications.waset.org/abstracts/12460/immunomodulatory-effects-of-multipotent-mesenchymal-stromal-cells-on-t-cell-populations-at-tissue-related-oxygen-level" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/12460.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">382</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3609</span> Understanding Chromosome Movement in Starfish Oocytes</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Bryony%20Davies">Bryony Davies</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Many cell and tissue culture practices ignore the effects of gravity on cell biology, and little is known about how cell components may move in response to gravitational forces. Starfish oocytes provide an excellent model for interrogating the movement of cell components due to their unusually large size, ease of handling, and high transparency. Chromosomes from starfish oocytes can be visualised by microinjection of the histone-H2B-mCherry plasmid into the oocytes. The movement of the chromosomes can then be tracked by live-cell fluorescence microscopy. The results from experiments using these methods suggest that there is a replicable downward movement of centrally located chromosomes at a median velocity of 0.39 μm/min. Chromosomes nearer the nuclear boundary showed more restricted movement. Chromosome density and shape could also be altered by microinjection of restriction enzymes, primarily Alu1, before imaging. This was found to alter the speed of chromosome movement, with chromosomes from Alu1-injected nuclei showing a median downward velocity of 0.60 μm/min. Overall, these results suggest that there is a non-negligible movement of chromosomes in response to gravitational forces and that this movement can be altered by enzyme activity. Future directions based on these results could interrogate if this observed downward movement extends to other cell components and to other cell types. Additionally, it may be important to understand whether gravitational orientation and vertical positioning of cell components alter cell behaviour. The findings here may have implications for current cell culture practices, which do not replicate cell orientations or external forces experienced in vivo. It is possible that a failure to account for gravitational forces in 2D cell culture alters experimental results and the accuracy of conclusions drawn from them. Understanding possible behavioural changes in cells due to the effects of gravity would therefore be beneficial. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=starfish" title="starfish">starfish</a>, <a href="https://publications.waset.org/abstracts/search?q=oocytes" title=" oocytes"> oocytes</a>, <a href="https://publications.waset.org/abstracts/search?q=live-cell%20imaging" title=" live-cell imaging"> live-cell imaging</a>, <a href="https://publications.waset.org/abstracts/search?q=microinjection" title=" microinjection"> microinjection</a>, <a href="https://publications.waset.org/abstracts/search?q=chromosome%20dynamics" title=" chromosome dynamics"> chromosome dynamics</a> </p> <a href="https://publications.waset.org/abstracts/158323/understanding-chromosome-movement-in-starfish-oocytes" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/158323.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">104</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3608</span> Follicular Thyroid Carcinoma in a Developing Country: A Retrospective Study of 10 Years</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Abdul%20Aziz">Abdul Aziz</a>, <a href="https://publications.waset.org/abstracts/search?q=Muhammad%20Qamar%20Masood"> Muhammad Qamar Masood</a>, <a href="https://publications.waset.org/abstracts/search?q=Saadia%20Sattar"> Saadia Sattar</a>, <a href="https://publications.waset.org/abstracts/search?q=Saira%20Fatima"> Saira Fatima</a>, <a href="https://publications.waset.org/abstracts/search?q=Najmul%20Islam"> Najmul Islam</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: The most common endocrine tumor is thyroid cancer. Follicular Thyroid Carcinoma (FTC) accounts for 5%–10% of all thyroid cancers. Patients with FTC frequently present with more advanced stage diseases and a higher occurrence of distant metastases because of the propensity of vascular invasion. FTC is mainly treated with surgery, while radioactive iodine therapy is the main adjuvant therapy as per ATA guidelines. In many developing countries, surgical facilities and radioactive iodine are in short supply; therefore, understanding follicular thyroid cancer trends may help developing countries plan and use resources more effectively. Methodology: It was a retrospective observational study of FTC patients of age 18 years and above conducted at Aga Khan University Hospital, Karachi, from 1st January 2010 to 31st December 2019. Results: There were 404 patients with thyroid carcinoma, out of which forty (10.1%) were FTC. 50% of the patients were in the 41-60 years age group, and the female to male ratio was 1.5: 1. Twenty-four patients (60%) presented with complain of neck swelling followed by metastasis (20%) and compressive symptoms (20%). The most common site of metastasis was bone (87.5%), followed by lung (12.5%). The pre-operative thyroglobulin level was done in six out of eight metastatic patients (75%) in which it was elevated. This emphasizes the importance of checking thyroglobulin level in unusual presentation (bone pain, fractures) of a patient having neck swelling also to help in establishing the primary source of tumor. There was no complete documentation of ultrasound features of the thyroid gland in all the patients, which is an important investigation done in the initial evaluation of thyroid nodule. On FNAC, 50% (20 patients) had Bethesda category III-IV nodules, while 10% ( 4 patients ) had Bethesda category II. In sixteen patients, FNAC was not done as they presented with compressive symptoms or metastasis. Fifty percent had a total thyroidectomy and 50% had subtotal followed by completion thyroidectomy, plus ten patients had lymph node dissection, out of which seven had histopathological lymph node involvement. On histopathology, twenty-three patients (57.5%) had minimally invasive, while seventeen (42.5%) had widely invasive follicular thyroid carcinoma. The capsular invasion was present in thirty-three patients (82.5%); one patient had no capsular invasion, but there was a vascular invasion. Six patients' histopathology had no record of capsular invasion. In contrast, the lymphovascular invasion was present in twenty-six patients (65%). In this study, 65 % of the patients had clinical stage 1 disease, while 25% had stage 2 and 10% had clinical stage 4. Seventeen patients (42.5%) had received RAI 30-100 mCi, while ten patients (25%) received more than 100 mCi. Conclusion: FTC demographic and clinicopathological presentation are the same in Pakistan as compared to other countries. Surgery followed by RAI is the mainstay of treatment. Thus understanding the trend of FTC and proper planning and utilization of the resources will help the developing countries in effectively treating the FTC. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=thyroid%20carcinoma" title="thyroid carcinoma">thyroid carcinoma</a>, <a href="https://publications.waset.org/abstracts/search?q=follicular%20thyroid%20carcinoma" title=" follicular thyroid carcinoma"> follicular thyroid carcinoma</a>, <a href="https://publications.waset.org/abstracts/search?q=clinicopathological%20features" title=" clinicopathological features"> clinicopathological features</a>, <a href="https://publications.waset.org/abstracts/search?q=developing%20countries" title=" developing countries"> developing countries</a> </p> <a href="https://publications.waset.org/abstracts/135561/follicular-thyroid-carcinoma-in-a-developing-country-a-retrospective-study-of-10-years" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/135561.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">192</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3607</span> A Study on Implementation of Optimal Soldering Temperature Profile through Deformation Analysisin Infrared Lamp Soldering of Photovoltaic Cells</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Taejung%20Lho">Taejung Lho</a>, <a href="https://publications.waset.org/abstracts/search?q=Jonghwan%20Lee"> Jonghwan Lee</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Most of the photovoltaic (PV) module manufacturers have recently interested in reducing the manufacturing cost. One of available solution is the use of the thin photovoltaic cell because of reducing of raw material cost. Thin PV cells, however, are damaged large deformation which causes possible microcracks inside PV cell, leading to failure problem. In this paper, deformation characteristics by heat conduction in soldering process of PV cells are analyzed through ANSYS software tool. They have been tested for different PV cell thickness and soldering temperature profile. Accordingly optimal soldering process to minimize the deformation of PV cell has been suggested. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=photovoltaic%20%28PV%29%20cell" title="photovoltaic (PV) cell">photovoltaic (PV) cell</a>, <a href="https://publications.waset.org/abstracts/search?q=infrared%28IR%29%20lamp%20soldering" title=" infrared(IR) lamp soldering"> infrared(IR) lamp soldering</a>, <a href="https://publications.waset.org/abstracts/search?q=optimal%20soldering%20temperature%20profile" title=" optimal soldering temperature profile"> optimal soldering temperature profile</a>, <a href="https://publications.waset.org/abstracts/search?q=deformation" title=" deformation"> deformation</a>, <a href="https://publications.waset.org/abstracts/search?q=temperature%20distribution" title=" temperature distribution"> temperature distribution</a>, <a href="https://publications.waset.org/abstracts/search?q=3D%20scanner" title=" 3D scanner"> 3D scanner</a>, <a href="https://publications.waset.org/abstracts/search?q=ANSYS" title=" ANSYS"> ANSYS</a> </p> <a href="https://publications.waset.org/abstracts/1447/a-study-on-implementation-of-optimal-soldering-temperature-profile-through-deformation-analysisin-infrared-lamp-soldering-of-photovoltaic-cells" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/1447.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">409</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3606</span> Active Power Control of PEM Fuel Cell System Power Generation Using Adaptive Neuro-Fuzzy Controller</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Khaled%20Mammar">Khaled Mammar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This paper presents an application of adaptive neuro-fuzzy controller for PEM fuel cell system. The model proposed for control include a fuel cell stack model, reformer model and DC/AC inverter model. Furthermore, a Fuzzy Logic (FLC) and adaptive neuro-fuzzy controllers are used to control the active power of PEM fuel cell system. The controllers modify the hydrogen flow feedback from the terminal load. The validity of the controller is verified when the fuel cell system model is used in conjunction with the ANFIS controller to predict the response of the active power. Simulation results confirmed the high-performance capability of the neuo-fuzzy to control power generation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=fuel%20cell" title="fuel cell">fuel cell</a>, <a href="https://publications.waset.org/abstracts/search?q=PEMFC" title=" PEMFC"> PEMFC</a>, <a href="https://publications.waset.org/abstracts/search?q=modeling" title=" modeling"> modeling</a>, <a href="https://publications.waset.org/abstracts/search?q=simulation" title=" simulation"> simulation</a>, <a href="https://publications.waset.org/abstracts/search?q=Fuzzy%20Logic%20Controller" title=" Fuzzy Logic Controller"> Fuzzy Logic Controller</a>, <a href="https://publications.waset.org/abstracts/search?q=FLC" title=" FLC"> FLC</a>, <a href="https://publications.waset.org/abstracts/search?q=adaptive%20neuro-fuzzy%20controller" title=" adaptive neuro-fuzzy controller"> adaptive neuro-fuzzy controller</a>, <a href="https://publications.waset.org/abstracts/search?q=ANFIS" title=" ANFIS"> ANFIS</a> </p> <a href="https://publications.waset.org/abstracts/30876/active-power-control-of-pem-fuel-cell-system-power-generation-using-adaptive-neuro-fuzzy-controller" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/30876.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">459</span> </span> </div> </div> <ul class="pagination"> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=squamous%20cell%20carcinoma&page=7" rel="prev">&lsaquo;</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=squamous%20cell%20carcinoma&page=1">1</a></li> <li class="page-item"><a class="page-link" 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