CINXE.COM
Developmental Control of Cell Cycle and Signaling
<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Strict//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-strict.dtd"> <html xmlns="http://www.w3.org/1999/xhtml" xml:lang="en" lang="en"> <head> <meta http-equiv="Content-Type" content="text/html; charset=UTF-8" /> <title>Developmental Control of Cell Cycle and Signaling </title> <meta name="googlebot" content="NOODP" /> <meta name="description" content="A new type of review journal, featuring comprehensive collections of expert review articles on important topics in the molecular life sciences" /> <meta content="/cshperspect/17/2/a041499.atom" name="HW.identifier" /> <meta name="DC.Format" content="text/html" /> <meta name="DC.Language" content="en" /> <meta content="Developmental Control of Cell Cycle and Signaling" name="DC.Title" /> <meta content="10.1101/cshperspect.a041499" name="DC.Identifier" /> <meta content="2025-02-01" name="DC.Date" /> <meta content="Cold Spring Harbor Laboratory Press" name="DC.Publisher" /> <meta content="Stefano Di Talia" name="DC.Contributor" /> <meta content="166" name="citation_collection_id" /> <meta content="Cold Spring Harbor Perspectives in Biology" name="citation_journal_title" /> <meta content="Cold Spring Harb Perspect Biol" name="citation_journal_abbrev" /> <meta content="Cold Spring Harbor Lab" name="citation_publisher" /> <meta content="" name="citation_issn" /> <meta content="1943-0264" name="citation_issn" /> <meta name="citation_author" content="Stefano Di Talia" /> <meta name="citation_author_orcid" content="0000-0001-9758-7925" /> <meta name="citation_author_institution" content="Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA" /> <meta content="Developmental Control of Cell Cycle and Signaling" name="citation_title" /> <meta content="02/01/2025" name="citation_date" /> <meta content="17" name="citation_volume" /> <meta content="2" name="citation_issue" /> <meta content="a041499" name="citation_firstpage" /> <meta content="17/2/a041499" name="citation_id" /> <meta content="17/2/a041499" name="citation_id_from_sass_path" /> <meta content="cshperspect;17/2/a041499" name="citation_mjid" /> <meta content="10.1101/cshperspect.a041499" name="citation_doi" /> <meta content="http://cshperspectives.cshlp.org/content/17/2/a041499.abstract" name="citation_abstract_html_url" /> <meta content="http://cshperspectives.cshlp.org/content/17/2/a041499.full" name="citation_fulltext_html_url" /> <meta content="http://cshperspectives.cshlp.org/content/17/2/a041499.full.pdf" name="citation_pdf_url" /> <meta content="/content/17/2.cover.gif" name="issue_cover_image" /> <meta content="http://cshperspectives.cshlp.org/content/17/2/a041499" name="citation_public_url" /> <meta content="38858070" name="citation_pmid" /> <meta name="citation_section" content="Perspective" /> <meta name="robots" content="noarchive" /> <link href="/content/17/2/a041448.short" rel="prev" /> <link href="/content/17/2/a041511.short" rel="next" /> <link rel="stylesheet" type="text/css" media="all" href="/shared/css/hw-global.css" /> <link rel="stylesheet" type="text/css" media="all" href="/shared/css/standard-designs/design2/main.css" /> <link rel="stylesheet" type="text/css" media="all" href="/publisher/css/hw-cshljnls-global.css" /> <link rel="stylesheet" type="text/css" media="all" href="/local/css/hw-journal-global.css" /> <link rel="stylesheet" type="text/css" media="all" href="/shared/css/hw-citation-2.0-hacks.css" /> <link rel="stylesheet" type="text/css" media="print" href="/shared/css/hw-print.css" /> <link rel="stylesheet" type="text/css" media="print" href="/publisher/css/hw-cshljnls-print.css" /> <link rel="stylesheet" type="text/css" media="all" href="/shared/css/hw-page-content.css" /> <link rel="stylesheet" type="text/css" media="all" href="/publisher/css/hw-cshljnls-page-content.css" /> <link rel="stylesheet" type="text/css" media="all" href="/local/css/hw-journal-page-content.css" /> <link rel="stylesheet" type="text/css" media="all" href="/site/misc/custom-global.css" /><script type="text/javascript" id="session-d4967769e1">var callbackToken='51570D31674A679';</script><script type="text/javascript" src="/shared/js/jquery-min.js"></script><script type="text/javascript" src="/shared/js/fingerprint.js"></script><script type="text/javascript" src="/shared/js/hw-shared.js"></script><script type="text/javascript" src="/shared/js/design/hw-design1.js"></script><script type="text/javascript" src="/publisher/js/cshl-shared.js"></script><script type="text/javascript" src="/shared/js/pages/hw-content.js"></script><script type="text/javascript" src="/publisher/js/cshl-content.js"></script><script type="text/javascript" async="async" src="https://scholar.google.com/scholar_js/casa.js"></script><script type="text/javascript" src="/site/misc/custom-global.js"></script></head> <body> <div class="hw-gen-page pagetype-content" id="pageid-content" itemscope="itemscope" itemtype="http://schema.org/ScholarlyArticle"> <div id="header"> <a href="/"><img title="Cold Spring Harbor Perspectives in Biology" alt="Cold Spring Harbor Perspectives in Biology" width="390" height="83" src="/local/img/journal_logo_standalone.gif" /></a> <p id="skip-link"> <a href="#content-block">Skip to main page content</a> </p> <ul class="button-list header-buttons"> <li class="first"><a href="/" title="HOME"><span>HOME</span></a></li> <li><a href="/site/misc/about.xhtml" title="ABOUT"><span>ABOUT</span></a></li> <li><a href="/cgi/collection/" title="SUBJECT COLLECTIONS"><span>SUBJECT COLLECTIONS</span></a></li> <li><a href="/content/by/year" title="ARCHIVE"><span>ARCHIVE</span></a></li> <li><a href="/site/misc/subscribe.xhtml" title="SUBSCRIBE"><span>SUBSCRIBE</span></a></li> <li><a href="/site/misc/adinfo.xhtml" title="ADVERTISE"><span>ADVERTISE</span></a></li> <li><a href="/site/misc/alertland.xhtml" title="ALERTS"><span>ALERTS</span></a></li> <li><a href="/feedback" title="FEEDBACK"><span>FEEDBACK</span></a></li> <li class="last"><a href="/help/" title="HELP"><span>HELP</span></a></li> </ul> <div class="header-qs"> <form class="searchbox" action="/search" method="get"> <div> <label for="header-qs-input" id="header-qs-search-label">Search for Keyword:</label> <input value="" title="Search Cold Spring Harbor Perspectives in Biology" type="text" name="fulltext" id="header-qs-input" /><input type="hidden" name="submit" value="yes" /><label for="header-qs-search" id="header-qs-search-label">GO</label><input value="GO" alt="Link: Go" type="image" id="header-qs-search-go" src="/shared/img/standard-design/design2/go.gif" /> </div> <div class="adv-search-link"><a href="/search">Advanced Search</a></div> </form> </div> <div class="header-ac-elements"> <div class="inst-branding"> </div> <div id="authstring" class="suppress-header-login"> </div> <div id="hdr-login" class="suppress-header-login"></div> </div> <div class="banner-ads"> <ul> <li><a href="/cgi/adclick/?ad=50833&adclick=true&url=http%3A%2F%2Fwww.genelink.com%2Fpct%2FSNP_Positive_Control_Template_Specifications.asp" target="_blank"><img class="adborder0" title="Gene Link" src="//cshperspectives.cshlp.org/adsystem/graphics/9445140553420212/cshperspect/SPCT_web_468x60.gif?ad=50833&adview=true" alt="Gene Link" /></a></li> </ul> </div> <div class="bar"> <div class="bar-inner"></div> </div> </div> <div id="content-block"> <div class="article abstract-view " itemprop="articleBody"><span class="highwire-journal-article-marker-start"></span><h1 id="article-title-1" itemprop="headline">Developmental Control of Cell Cycle and Signaling</h1> <div class="contributors"> <ol class="contributor-list" id="contrib-group-1"> <li class="last" id="contrib-1"><span class="name"><a class="name-search" href="/search?author1=Stefano+Di+Talia&sortspec=date&submit=Submit">Stefano Di Talia</a></span></li> </ol> <ol class="affiliation-list"> <li class="aff"><a id="aff-1" name="aff-1"></a><address>Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA</address> </li> </ol> <ol class="corresp-list"> <li class="corresp" id="corresp-1"><em>Correspondence:</em> <span class="em-link"><span class="em-addr">stefano.ditalia{at}duke.edu</span></span></li> </ol> </div> <div class="section abstract" id="abstract-1" itemprop="description"> <h2>Abstract</h2> <p id="p-3">In most species, the earliest stages of embryogenesis are characterized by rapid proliferation, which must be tightly controlled with other cellular processes across the large scale of the embryo. The study of this coordination has recently revealed new mechanisms of regulation of morphogenesis. Here, I discuss progress on how the integration of biochemical and mechanical signals leads to the proper positioning of cellular components, how signaling waves ensure the synchronization of the cell cycle, and how cell cycle transitions are properly timed. Similar concepts are emerging in the control of morphogenesis of other tissues, highlighting both common and unique features of early embryogenesis. </p> </div> <ul class="copyright-statement"> <li class="fn" id="copyright-statement-1"><a href="http://www.cshperspectives.org/site/misc/terms.xhtml">Copyright 漏 2025 Cold Spring Harbor Laboratory Press; all rights reserved</a></li> </ul><span class="highwire-journal-article-marker-end"></span></div> <div class="social-bookmarking"> <ul class="social-bookmark-links"> <li class="social-bookmarking-item social-bookmarking-item-citeulike"><a href="/external-ref?tag_url=http://cshperspectives.cshlp.org/cgi/content/long/17/2/a041499&title=Developmental%20Control%20of%20Cell%20Cycle%20and%20Signaling+--+Di%20Talia%2017%20%282%29+--+cshperspect&doi=10.1101/cshperspect.a041499&link_type=CITEULIKE"><img src="/shared/img/common/social-bookmarking/citeulike.gif" alt="Add to CiteULike" title="CiteULike" /></a><span class="soc-bm-link-text">CiteULike</span></li> <li class="social-bookmarking-item social-bookmarking-item-delicious"><a href="/external-ref?tag_url=http://cshperspectives.cshlp.org/cgi/content/long/17/2/a041499&title=Developmental%20Control%20of%20Cell%20Cycle%20and%20Signaling+--+Di%20Talia%2017%20%282%29+--+cshperspect&doi=10.1101/cshperspect.a041499&link_type=DEL_ICIO_US"><img src="/shared/img/common/social-bookmarking/delicious.gif" alt="Add to Delicious" title="Delicious" /></a><span class="soc-bm-link-text">Delicious</span></li> <li class="social-bookmarking-item social-bookmarking-item-digg"><a href="/external-ref?tag_url=http://cshperspectives.cshlp.org/cgi/content/long/17/2/a041499&title=Developmental%20Control%20of%20Cell%20Cycle%20and%20Signaling+--+Di%20Talia%2017%20%282%29+--+cshperspect&doi=10.1101/cshperspect.a041499&link_type=DIGG"><img src="/shared/img/common/social-bookmarking/digg.gif" alt="Add to Digg" title="Digg" /></a><span class="soc-bm-link-text">Digg</span></li> <li class="social-bookmarking-item social-bookmarking-item-facebook"><a href="/external-ref?tag_url=http://cshperspectives.cshlp.org/cgi/content/short/17/2/a041499&title=Developmental%20Control%20of%20Cell%20Cycle%20and%20Signaling+--+Di%20Talia%2017%20%282%29+--+cshperspect&doi=10.1101/cshperspect.a041499&link_type=FACEBOOK" class="sb-facebook" rel="external-nw"><img src="/shared/img/common/social-bookmarking/facebook.gif" alt="Add to Facebook" title="Facebook" /></a><span class="soc-bm-link-text">Facebook</span></li> <li class="social-bookmarking-item social-bookmarking-item-reddit"><a href="/external-ref?tag_url=http://cshperspectives.cshlp.org/cgi/content/long/17/2/a041499&title=Developmental%20Control%20of%20Cell%20Cycle%20and%20Signaling+--+Di%20Talia%2017%20%282%29+--+cshperspect&doi=10.1101/cshperspect.a041499&link_type=REDDIT"><img src="/shared/img/common/social-bookmarking/reddit.gif" alt="Add to Reddit" title="Reddit" /></a><span class="soc-bm-link-text">Reddit</span></li> <li class="social-bookmarking-item social-bookmarking-item-twitter"><a href="/external-ref?tag_url=http://cshperspectives.cshlp.org/cgi/content/long/17/2/a041499&title=Developmental%20Control%20of%20Cell%20Cycle%20and%20Signaling+--+Di%20Talia%2017%20%282%29+--+cshperspect&doi=10.1101/cshperspect.a041499&link_type=TWITTER"><img src="/shared/img/common/social-bookmarking/twitter.gif" alt="Add to Twitter" title="Twitter" /></a><span class="soc-bm-link-text">Twitter</span></li> </ul> <p class="social-bookmarking-help"><a href="/help/social_bookmarks.dtl">What's this?</a></p> </div><span id="related-urls"></span> <br /> <br /> <div class="content-box" id="article-cb-mainy" style="background-color: #f8efd5;"> <div class="cb-contents" style="background-color: #f8efd5;"> <div style="background-color: #f8efd5;"> <h4 class="cb-section-header" style="background-color: #f8efd5;padding-top:12px;"> <span style="background-color: #f8efd5;">Also in this Collection</span> </h4> <ol></ol> <ol class="tweet" id="coll_list_abstract"></ol> </div> </div> </div> <div id="content-end-sb" class="sb-div"></div> </div> <div id="col-2"> <div class="article-nav sidebar-nav"> <a href="/content/17/2/a041448.short" title="Previous article" class="previous">芦 Previous</a><span class="article-nav-sep"> | </span><a href="/content/17/2/a041511.short" title="Next article" class="next">Next Article 禄</a> <span class="toc-link"> <a href="/content/17/2.toc" title="Table of Contents">Table of Contents</a> </span> </div> <div class="content-box" id="article-cb-main"> <div class="cb-contents"> <h3 class="cb-contents-header"><span>This Article</span></h3> <div class="cb-section cb-slug"> <ol> <li> <div id="slugline"> <span class="slug-metadata-note ahead-of-print"> Published in Advance <span class="slug-ahead-of-print-date">June 10, 2024</span>, doi: <span title="10.1101/cshperspect.a041499" class="slug-doi">10.1101/cshperspect.a041499 </span> </span> <cite> <abbr title="Cold Spring Harbor Perspectives in Biology" class="slug-jnl-abbrev"> Cold Spring Harb. Perspect. Biol.</abbr><span class="slug-pub-date" itemprop="datePublished"> 2025. </span> <span class="slug-vol"> 17: </span> <span class="slug-elocation"> a041499 </span> </cite> <a href="/site/misc/terms.xhtml"><span class="copyright-statement"> <nlm:ext-link xmlns:nlm="http://schema.highwire.org/NLM/Journal" xmlns:l="http://schema.highwire.org/Linking" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:hwp="http://schema.highwire.org/Journal" l:rel="related" l:ref-type="uri" l:ref="http://www.cshperspectives.org/site/misc/terms.xhtml" ext-link-type="uri" xlink:href="http://www.cshperspectives.org/site/misc/terms.xhtml" hwp:id="ext-link-1">Copyright 漏 2025 Cold Spring Harbor Laboratory Press; all rights reserved</nlm:ext-link></span></a> </div> </li> </ol> </div> <div class="cb-section" id="cb-art-links"> <ol> <li><span class="variant-indicator">禄 <span>Abstract</span></span><span class="free">Free</span></li> <li class="notice"><a href="/content/17/2/a041499.full" rel="view-full-text">Full Text</a><span class="free">Free</span></li> <li class="notice"><a href="/content/17/2/a041499.full.pdf+html" rel="view-full-text.pdf">Full Text (PDF)</a><span class="free">Free</span></li> <li class="cb-versions"> <div><span id="pap-all-versions-label">All Versions of this Article:</span><ol class="version-list"> <li><a href="/content/early/2024/06/10/cshperspect.a041499">cshperspect.a041499v1</a></li> <li class="current-li"><span>17/2/a041499</span> <span class="current-version">most recent</span></li> </ol> </div> </li> </ol> </div> <div class="cb-section collapsible" id="cb-art-cat"> <h4 class="cb-section-header"><span>Article Category</span></h4> <ol> <li> <ul class="subject-headings"> <li>Perspective <ul class="subject-sub-headings last-child"> <li><a class="tocsection-search" href="/search?tocsectionid=Developmental+Biology&sortspec=date&submit=Submit">Developmental Biology</a></li> </ul> </li> </ul> </li> </ol> </div> <div class="cb-section collapsible default-closed" id="cb-art-svcs"> <h4 class="cb-section-header"><span>Services</span></h4> <ol> <li><a href="/cgi/alerts/ctalert?alertType=citedby&addAlert=cited_by&cited_by_criteria_resid=cshperspect%3B17%2F2%2Fa041499&saveAlert=no&return-type=article&return_url=http://cshperspectives.cshlp.org/content/17/2/a041499.abstract">Alert me when this article is cited</a></li> <li><a href="/cgi/alerts/ctalert?alertType=correction&addAlert=correction&correction_criteria_value=17/2/a041499&saveAlert=no&return-type=article&return_url=http://cshperspectives.cshlp.org/content/17/2/a041499.abstract">Alert me if a correction is posted</a></li> <li><a href="/search?qbe=cshperspect%3Bcshperspect.a041499&citation=Di%20Talia%2017%20%282%29&submit=yes">Similar articles in this journal</a></li> <li><a href="/external-ref?access_num=cshperspect%3B17%2F2%2Fa041499&link_type=ISI_RELATEDRECORDS" id="cb-isi-similar-articles">Similar articles in Web of Science</a></li> <li><a href="/external-ref?access_num=38858070&link_type=MED_NBRS">Similar articles in PubMed</a></li> <li><a href="/citmgr?gca=cshperspect%3B17%2F2%2Fa041499">Download to citation manager</a></li> <li><a href="/site/misc/permissions_landing.xhtml"> Permissions </a></li> </ol> </div> <div class="cb-section collapsible default-closed" id="cb-letter-cit"> <h4 class="cb-section-header"><span>Updates/Comments</span></h4> <ol> <li><a href="/letters/submit/cshperspect;17/2/a041499">Submit Updates/Comments</a></li> <li><span class="eletters-no-responses-published">No Updates/Comments published</span></li> </ol> </div> <div class="cb-section collapsible default-closed" id="cb-art-cit"> <h4 class="cb-section-header"><span>Citing Articles</span></h4> <ol> <li><a href="/content/17/2/a041499.abstract?cited-by=yes&legid=cshperspect;17/2/a041499#cited-by" id="cb-hw-citing-articles">Load citing article information</a></li> <li><a href="/external-ref?access_num=%2Fcshperspect%2F17%2F2%2Fa041499&link_type=ISI_CITING&accnum_type=native" rel="external-nw" id="cb-isi-citing-articles">Citing articles via Web of Science</a></li> </ol> </div> <div class="cb-section collapsible default-closed" id="cb-art-gs"> <h4 class="cb-section-header"><span>Google Scholar</span></h4> <ol> <li><a href="http://scholar.google.com/scholar?q=%22author%3ADi%20Talia%20author%3AS.%22">Articles by Di Talia, S.</a></li> <li><a href="/external-ref?access_num=http://cshperspectives.cshlp.org/content/17/2/a041499.abstract&link_type=GOOGLESCHOLARRELATED">Search for related content</a></li> </ol> </div> <div class="cb-section collapsible default-closed" id="cb-art-pm"> <h4 class="cb-section-header"><span>PubMed/NCBI</span></h4> <ol> <li><a href="/external-ref?access_num=38858070&link_type=PUBMED">PubMed citation</a></li> <li><a href="/external-ref?access_num=Di%20Talia%20S&link_type=AUTHORSEARCH">Articles by Di Talia, S.</a></li> <li> <div id="cb-entrez-links-placeholder"><a href="/entrez-links/38858070"></a></div> </li> </ol> </div> <div class="cb-section collapsible default-closed" id="cb-art-orcid"> <h4 class="cb-section-header"><span>ORCID</span></h4> <ol> <li class="cb-art-orcid-auth author-link"> <span xmlns="" class="orcid-author">Profile for Di Talia, S.<a class="orcid-link" href="http://orcid.org/0000-0001-9758-7925">http://orcid.org/0000-0001-9758-7925</a></span> </li> </ol> </div> <div class="cb-section collapsible default-open" id="cb-art-col"> <h4 class="cb-section-header"><span>Subject Collections</span></h4> <ol> <li><a href="/cgi/collection/developmental_dynamics_guided_morphogenesis_and_self_-_organization_across_scales">Developmental Dynamics: Guided Morphogenesis and Self-Organization across Scales</a></li> </ol> </div> <div class="cb-section collapsible default-closed" id="cb-art-soc"> <h4 class="cb-section-header"><span>Share</span></h4> <ol> <li><a href="/email?gca=cshperspect%3B17%2F2%2Fa041499&current-view-path=/content/17/2/a041499.abstract"></a></li> <li> <div class="social-bookmarking"> <ul class="social-bookmark-links"> <li class="social-bookmarking-item social-bookmarking-item-citeulike"><a href="/external-ref?tag_url=http://cshperspectives.cshlp.org/cgi/content/long/17/2/a041499&title=Developmental%20Control%20of%20Cell%20Cycle%20and%20Signaling+--+Di%20Talia%2017%20%282%29+--+cshperspect&doi=10.1101/cshperspect.a041499&link_type=CITEULIKE"><img src="/shared/img/common/social-bookmarking/citeulike.gif" alt="Add to CiteULike" title="CiteULike" /></a><span class="soc-bm-link-text">CiteULike</span></li> <li class="social-bookmarking-item social-bookmarking-item-delicious"><a href="/external-ref?tag_url=http://cshperspectives.cshlp.org/cgi/content/long/17/2/a041499&title=Developmental%20Control%20of%20Cell%20Cycle%20and%20Signaling+--+Di%20Talia%2017%20%282%29+--+cshperspect&doi=10.1101/cshperspect.a041499&link_type=DEL_ICIO_US"><img src="/shared/img/common/social-bookmarking/delicious.gif" alt="Add to Delicious" title="Delicious" /></a><span class="soc-bm-link-text">Delicious</span></li> <li class="social-bookmarking-item social-bookmarking-item-digg"><a href="/external-ref?tag_url=http://cshperspectives.cshlp.org/cgi/content/long/17/2/a041499&title=Developmental%20Control%20of%20Cell%20Cycle%20and%20Signaling+--+Di%20Talia%2017%20%282%29+--+cshperspect&doi=10.1101/cshperspect.a041499&link_type=DIGG"><img src="/shared/img/common/social-bookmarking/digg.gif" alt="Add to Digg" title="Digg" /></a><span class="soc-bm-link-text">Digg</span></li> <li class="social-bookmarking-item social-bookmarking-item-facebook"><a href="/external-ref?tag_url=http://cshperspectives.cshlp.org/cgi/content/short/17/2/a041499&title=Developmental%20Control%20of%20Cell%20Cycle%20and%20Signaling+--+Di%20Talia%2017%20%282%29+--+cshperspect&doi=10.1101/cshperspect.a041499&link_type=FACEBOOK" class="sb-facebook" rel="external-nw"><img src="/shared/img/common/social-bookmarking/facebook.gif" alt="Add to Facebook" title="Facebook" /></a><span class="soc-bm-link-text">Facebook</span></li> <li class="social-bookmarking-item social-bookmarking-item-reddit"><a href="/external-ref?tag_url=http://cshperspectives.cshlp.org/cgi/content/long/17/2/a041499&title=Developmental%20Control%20of%20Cell%20Cycle%20and%20Signaling+--+Di%20Talia%2017%20%282%29+--+cshperspect&doi=10.1101/cshperspect.a041499&link_type=REDDIT"><img src="/shared/img/common/social-bookmarking/reddit.gif" alt="Add to Reddit" title="Reddit" /></a><span class="soc-bm-link-text">Reddit</span></li> <li class="social-bookmarking-item social-bookmarking-item-twitter"><a href="/external-ref?tag_url=http://cshperspectives.cshlp.org/cgi/content/long/17/2/a041499&title=Developmental%20Control%20of%20Cell%20Cycle%20and%20Signaling+--+Di%20Talia%2017%20%282%29+--+cshperspect&doi=10.1101/cshperspect.a041499&link_type=TWITTER"><img src="/shared/img/common/social-bookmarking/twitter.gif" alt="Add to Twitter" title="Twitter" /></a><span class="soc-bm-link-text">Twitter</span></li> </ul> <p class="social-bookmarking-help"><a href="/help/social_bookmarks.dtl">What's this?</a></p> </div> </li> </ol> </div> </div> </div> <style type="text/css"> #col-2 div#cb-biorxiv ol { font-weight:normal; list-style-position:outside; list-style-type:none; list-style-image:url(/publisher/icons/col2-dash.gif); margin-left:4px; } #col-2 #article-cb-mainx { display:visible; } #col-2 div#cb-art-coll ol { font-weight:normal; list-style-position:outside; list-style-type:none; list-style-image:url(/publisher/icons/col2-dash.gif); margin-left:4px; } </style> <div id="col-2-widget-placeholder"> <div class="content-box" id="article-cb-main"> <div class="cb-contents"> <a href="http://biorxiv.org/" rel="external-nw"> <img src="/site/misc/images/biorxiv_ad.gif" /> </a> </div> </div> <div class="content-box" id="author_chat"> <div class="cb-contents"> <h3 class="cb-contents-header"><span>Interview</span></h3> <center><a href="http://mediacentral2.cshl.edu/Symposium75/Symposium75/Interviews/Entries/2010/6/24_TOM_MISTELI.html" onclick="newWindow(this.href, 'popup', 640, 378, 1, 1, 0, 0, 0, 1, 0); return false;"> <img alt="Misteli interview" src="/site/misc/images/misteli3.jpg" style="margin-top:15px;margin-bottom:4px;" /> </a></center> <div style="padding-left:2px;padding-right:2px;"> <a href="http://mediacentral2.cshl.edu/Symposium75/Symposium75/Interviews/Entries/2010/6/24_TOM_MISTELI.html" onclick="newWindow(this.href, 'popup', 640, 380, 1, 1, 0, 0, 0, 1, 0); return false;" style="font-size:8pt;">Click to see an interview with subject collection editor Tom Misteli </a> </div> </div> </div> <div class="content-box" id="author_chat1"> <div class="cb-contents"> <h3 class="cb-contents-header"><span>Interview</span></h3> <center><a href="http://mediacentral.cshl.edu/symp09/cech.mov" onclick="newWindow(this.href, 'popup', 324, 260, 1, 1, 0, 0, 0, 1, 0); return false;"> <img alt="Cech interview" src="/site/misc/images/tcech.jpg" style="margin-top:15px;margin-bottom:4px;" /> </a></center> <div style="padding-left:2px;padding-right:2px;"> <a href="http://mediacentral.cshl.edu/symp09/cech.mov" onclick="newWindow(this.href, 'popup', 324, 260, 1, 1, 0, 0, 0, 1, 0); return false;" style="font-size:8pt;">Click to see an interview with subject collection editor Tom Cech </a> </div> </div> </div> <div class="content-box" id="author_chat2"> <div class="cb-contents"> <h3 class="cb-contents-header"><span>Interview</span></h3> <center><a href="http://mediacentral.cshl.edu/symp09/shapiro.mov" onclick="newWindow(this.href, 'popup', 324, 260, 1, 1, 0, 0, 0, 1, 0); return false;"> <img alt="Shapiro interview" src="/site/misc/images/Shapiro_pic.jpg" style="margin-top:15px;margin-bottom:4px;" /> </a></center> <div style="padding-left:2px;padding-right:2px;"> <a href="http://mediacentral.cshl.edu/symp09/shapiro.mov" onclick="newWindow(this.href, 'popup', 324, 260, 1, 1, 0, 0, 0, 1, 0); return false;" style="font-size:8pt;">Click to see an interview with subject collection editor Lucy Shapiro</a> </div> </div> </div> <div class="content-box" id="author_chat3"> <div class="cb-contents"> <h3 class="cb-contents-header"><span>Interview</span></h3> <center><a href="http://mediacentral2.cshl.edu/Symposium76/Symposium76/Interviews/Entries/2011/6/2_Paolo_Sassone-Corsi.html" onclick="newWindow(this.href, 'popup', 324, 260, 1, 1, 0, 0, 0, 1, 0); return false;"> <img alt="Corsi interview" src="/site/misc/images/corsi.jpg" style="margin-top:15px;margin-bottom:4px;" /> </a></center> <div style="padding-left:2px;padding-right:2px;"> <a href="http://mediacentral2.cshl.edu/Symposium76/Symposium76/Interviews/Entries/2011/6/2_Paolo_Sassone-Corsi.html" onclick="newWindow(this.href, 'popup', 324, 260, 1, 1, 0, 0, 0, 1, 0); return false;" style="font-size:8pt;">Click to see an interview with subject collection editor Paolo Sassone-Corsi</a> </div> </div> </div> <div class="content-box" id="author_chat4"> <div class="cb-contents"> <h3 class="cb-contents-header"><span>Interview</span></h3> <center><a href="http://mediacentral2.cshl.edu/Symposium76/Symposium76/Interviews/Entries/2011/6/3_Richard_Morimoto_1.html" onclick="newWindow(this.href, 'popup', 324, 260, 1, 1, 0, 0, 0, 1, 0); return false;"> <img alt="Corsi interview" src="/site/misc/images/rm.jpg" style="margin-top:15px;margin-bottom:4px;" /> </a></center> <div style="padding-left:2px;padding-right:2px;"> <a href="http://mediacentral2.cshl.edu/Symposium76/Symposium76/Interviews/Entries/2011/6/3_Richard_Morimoto_1.html" onclick="newWindow(this.href, 'popup', 324, 260, 1, 1, 0, 0, 0, 1, 0); return false;" style="font-size:8pt;">Click to see an interview with subject collection editor Richard Morimoto</a> </div> </div> </div> <div class="content-box" id="author_chat5"> <div class="cb-contents"> <h3 class="cb-contents-header"><span>Interview</span></h3> <center><a href="http://mediacentral2.cshl.edu/Symposium77/Estelle.html" onclick="newWindow(this.href, 'popup', 1124, 960, 1, 1, 0, 0, 0, 1, 0); return false;"> <img alt="Estelle interview" src="/site/misc/images/estelle.jpg" style="margin-top:15px;margin-bottom:4px;" /> </a></center> <div style="padding-left:2px;padding-right:2px;"> <a href="http://mediacentral2.cshl.edu/Symposium77/Estelle.html" onclick="newWindow(this.href, 'popup',1124, 960, 1, 1, 0, 0, 0, 1, 0); return false;" style="font-size:8pt;">Click to see an interview with subject collection editor Mark Estelle</a> </div> </div> </div> <div class="content-box" id="author_chat6"> <div class="cb-contents"> <h3 class="cb-contents-header"><span>Interview</span></h3> <center><a href="http://mediacentral2.cshl.edu/Symposium76/Symposium76/Interviews/Entries/2011/6/2_Craig_Thompson_1.html" onclick="newWindow(this.href, 'popup', 1124, 960, 1, 1, 0, 0, 0, 1, 0); return false;"> <img alt="Craig Thompson interview" src="/site/misc/images/ct.jpg" style="margin-top:15px;margin-bottom:4px;" /> </a></center> <div style="padding-left:2px;padding-right:2px;"> <a href="http://mediacentral2.cshl.edu/Symposium76/Symposium76/Interviews/Entries/2011/6/2_Craig_Thompson_1.html" onclick="newWindow(this.href, 'popup',1124, 960, 1, 1, 0, 0, 0, 1, 0); return false;" style="font-size:8pt;">Click to see an interview with Craig Thompson</a> </div> </div> </div> <div class="content-box" id="author_chat7"> <div class="cb-contents"> <h3 class="cb-contents-header"><span>Interview</span></h3> <center><a href="http://mediacentral2.cshl.edu/symposium78/Mathis.html" onclick="newWindow(this.href, 'popup', 1124, 960, 1, 1, 0, 0, 0, 1, 0); return false;"> <img alt="Craig Thompson interview" src="/site/misc/images/dm.jpg" style="margin-top:15px;margin-bottom:4px;" /> </a></center> <div style="padding-left:2px;padding-right:2px;"> <a href="http://mediacentral2.cshl.edu/symposium78/Mathis.html" onclick="newWindow(this.href, 'popup',1124, 960, 1, 1, 0, 0, 0, 1, 0); return false;" style="font-size:8pt;">Click to see an interview with Diane Mathis</a> </div> </div> </div> <style type="text/css"> #col-2 #article-cb-mainx { display:visible; } #col-2 div#cb-art-coll ol { font-weight:normal; list-style-position:outside; list-style-type:none; list-style-image:url(/publisher/icons/col2-dash.gif); margin-left:4px; } </style> <div class="content-box" id="article-cb-mainx"> <div class="cb-contents"> <div class="cb-section collapsible default-open" id="cb-art-coll"> <h4 class="cb-section-header"> <span>In this Collection</span> </h4> <ol class="tweet" id="coll_list"></ol> </div> </div> </div> <script type="text/JavaScript"> var pageid = $("div.hw-gen-page").attr("id"); //alert(pageid); </script> </div> <ul class="tower-ads"> <li class="no-ad tower_col_2"><span> </span></li> </ul> </div> <div id="col-3"> <div class="content-box" id="sidebar-current-issue"> <div class="cb-contents"> <h3 class="cb-contents-header"><span>Current Issue</span></h3> <div class="cb-section"> <ol> <li><span><a href="/content/current" rel="current-issue">February 2025, 17 (2)</a></span></li> </ol> </div> <div class="cb-section"> <ol> <li> <div class="current-issue"><a href="/content/current" rel="current-issue"><img src="/content/17/2.cover.gif" width="67" height="89" alt="Current Issue" /></a></div> </li> </ol> </div> <cb:item xmlns:cb="http://schema.highwire.org/Site/Content-Box"> <div class="cb-section collapsible default-closed" id="sidebar-cur-issue-coverlines"> <h4 class="cb-section-header"> <span>From the cover</span> </h4> <ul> <li> <a>A collage of collection cover images</a> </li> </ul> </div> </cb:item> </div> </div> <div id="sidebar-global-nav"> <ul class="button-list pub-links"> <li class="first"><a href="/content/early/recent" title="Early Release Articles"><span>Early Release Articles</span></a></li> <li><a href="/site/misc/sample.xhtml" title="Featured Articles"><span>Featured Articles</span></a></li> <li><a href="/cgi/collection/" title="Subject Collections"><span>Subject Collections</span></a></li> <li><a href="/content/by/year" title="Archive by Date"><span>Archive by Date</span></a></li> <li><a href="/site/misc/alertland.xhtml" title="Alerts and RSS Feeds"><span>Alerts and RSS Feeds</span></a></li> <li><a href="http://www.cshlpress.com/library/?hwinfo" title="Recommend to Your Library"><span>Recommend to Your Library</span></a></li> <li class="last"><a href="/site/misc/permissions_landing.xhtml" title="Permissions"><span>Permissions</span></a></li> </ul> </div> <ul class="tower-ads"> <li><a href="/cgi/adclick/?ad=50843&adclick=true&url=http%3A%2F%2Fwww.genelink.com%2Fsirna%2FRNAprice.asp" target="_blank"><img class="adborder0" title="Gene Link 90s siRNA" src="//cshperspectives.cshlp.org/adsystem/graphics/9445140553420212/cshperspect/90siRNA-120x600_2.gif?ad=50843&adview=true" alt="Gene Link 90s siRNA" /></a></li> </ul> <div id="col-3-widget-placeholder" style="padding-top:5px;"> <p style="text-align:center;font-weight:bold;font-size:12px;line-height:15px;margin-top:0;padding-top:0;margin-bottom:0px;color:black;"> <a href="https://www.cshlpress.com/link/molclon4p.htm" style="color:black;">Molecular Cloning<br />The New Edition<br /> <span style=" color: red; ">Buy Now and Save 30%</span> </a> <br />Paperback only<br />(limited time offer) </p> <table style="border-spacing:6px;font-size: 80%;"> <tr> <td style="padding-bottom:6px;padding-top:2px;padding-left:12px;vertical-align:top;"> <a href="https://www.cshlpress.com/link/molclon4p.htm"> <img src="https://www.cshlpress.com/productgraphics/small/Molclon4-1.jpg" alt="Support Research and Save at CSHL Press" /> </a> </td> <td style="padding-bottom:9px;padding-left:6px;padding-right:12px;vertical-align:middle;"> <a href="https://www.cshlpress.com/link/molclon4p.htm">Molecular Cloning: A Laboratory Manual (Fourth Edition)</a> </td> </tr> </table> <div id="ads3" style="padding:0p;margin:0;"> 聽 </div> <br /> <br /> <div> <center><img alt="CSH Perspectives" src="/site/misc/covers_hompage/cshlp.jpg" /></center> </div> </div> </div> <div id="footer"> <div class="bar"> <div class="footer-group footer-col-left"> <ul class="button-list footer-buttons"> <li class="first"><a href="/" title="Home"><span>Home</span></a></li> <li><a href="/site/misc/about.xhtml" title="About"><span>About</span></a></li> <li><a href="/cgi/collection/" title="Subject Collections"><span>Subject Collections</span></a></li> <li><a href="/content/by/year" title="Archive"><span>Archive</span></a></li> <li><a href="/site/misc/subscribe.xhtml" title="Subscribe"><span>Subscribe</span></a></li> <li><a href="/site/misc/adinfo.xhtml" title="Advertise"><span>Advertise</span></a></li> <li><a href="/site/misc/alertland.xhtml" title="Alerts"><span>Alerts</span></a></li> <li><a href="/feedback" title="Feedback"><span>Feedback</span></a></li> <li class="last"><a href="/help/" title="Help"><span>Help</span></a></li> </ul> <p class="copyright"><a href="http://www.cshlpress.com/" rel="external-nw">Copyright 漏 2025 by Cold Spring Harbor Laboratory Press</a></p> </div> <div class="footer-group footer-col-right"> <ul class="issns"> <li> <span>Online ISSN: </span> <span class="issn">1943-0264</span> </li> </ul> </div> </div> <div class="block-2 sb-div"></div> <script type="text/javascript"> document.write(unescape("%3Cscript async src='https://www.googletagmanager.com/gtag/js?id=G-BRRJG2L7NN'%3E%3C/script%3E")); </script><script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-BRRJG2L7NN'); </script> </div><script type="text/javascript"> document.write(unescape("%3Cscript async src='https://www.googletagmanager.com/gtag/js?id=G-1CWXPJ6EVC'%3E%3C/script%3E")); </script><script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-1CWXPJ6EVC'); </script></div> </body> </html>