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Clack</title> <meta name="description" content="Search results for: Lesley Clack"> <meta name="keywords" content="Lesley Clack"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler 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id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="Lesley Clack"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 16</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: Lesley Clack</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">16</span> A Comparative Study of the Evolution of Disparities in Salaries of Hospital Executives</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Lesley%20Clack">Lesley Clack</a>, <a href="https://publications.waset.org/abstracts/search?q=Rachel%20Ellison"> Rachel Ellison</a>, <a href="https://publications.waset.org/abstracts/search?q=Elizabeth%20Chambers"> Elizabeth Chambers</a> </p> <p class="card-text"><strong>Abstract:</strong></p> A belief exists that there are huge gender and racial disparities among hospital CEO’s in the United States, and historically, male, Caucasian healthcare executives have made significantly larger salaries than females and other races. With a recent focus on reducing barriers and disparities in healthcare, it remains to be seen whether there have been changes in these disparities over time. The purpose of this study was to explore disparities among salaries of hospital executives in the United States. Analysis of salary data was conducted utilizing online hospital salary databases. Statistical analysis was conducted to examine the significance of the differences. Results indicated that there had been improvements in disparities among some ethnicities. Gender disparities remain the largest gap. The implications of this study are significant for the field of healthcare management as disparities can affect both social dynamics and organizational culture. Understanding where disparities lie is the first step towards bridging the gap and reducing barriers for cultural diversity within healthcare management. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=health%20care" title="health care">health care</a>, <a href="https://publications.waset.org/abstracts/search?q=disparities" title=" disparities"> disparities</a>, <a href="https://publications.waset.org/abstracts/search?q=management" title=" management"> management</a>, <a href="https://publications.waset.org/abstracts/search?q=executives" title=" executives"> executives</a> </p> <a href="https://publications.waset.org/abstracts/112748/a-comparative-study-of-the-evolution-of-disparities-in-salaries-of-hospital-executives" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/112748.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">123</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">15</span> Designing and Enacting an Adjunct Faculty Self-Study of Teaching Community </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Anastasia%20P.%20Samaras">Anastasia P. Samaras</a>, <a href="https://publications.waset.org/abstracts/search?q=Allison%20Ward-Parsons"> Allison Ward-Parsons</a>, <a href="https://publications.waset.org/abstracts/search?q=Beth%20Dalbec"> Beth Dalbec</a>, <a href="https://publications.waset.org/abstracts/search?q=Paula%20Cristina%20Azevedo"> Paula Cristina Azevedo</a>, <a href="https://publications.waset.org/abstracts/search?q=Anya%20Evmenova"> Anya Evmenova</a>, <a href="https://publications.waset.org/abstracts/search?q=Arvinder%20Johri"> Arvinder Johri</a>, <a href="https://publications.waset.org/abstracts/search?q=Lynne%20Scott%20Constantine"> Lynne Scott Constantine</a>, <a href="https://publications.waset.org/abstracts/search?q=Lesley%20Smith"> Lesley Smith </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Two cycles of qualitative data were collected. Cycle One sources included participant survey results, participant postings on Blackboard forums, facilitator memos, and meeting notes as well as reflections and notes from whole-group meetings. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=adjunct%20faculty" title="adjunct faculty">adjunct faculty</a>, <a href="https://publications.waset.org/abstracts/search?q=professional%20development" title=" professional development"> professional development</a>, <a href="https://publications.waset.org/abstracts/search?q=self-study%20methodology" title=" self-study methodology"> self-study methodology</a>, <a href="https://publications.waset.org/abstracts/search?q=teaching" title=" teaching"> teaching</a> </p> <a href="https://publications.waset.org/abstracts/112237/designing-and-enacting-an-adjunct-faculty-self-study-of-teaching-community" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/112237.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">162</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14</span> Women, Ethnic Minorities and Electoral Success</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Karen%20Lesley%20Webster">Karen Lesley Webster</a>, <a href="https://publications.waset.org/abstracts/search?q=Charles%20Crothers"> Charles Crothers</a> </p> <p class="card-text"><strong>Abstract:</strong></p> As the population of the Auckland region in New Zealand becomes markedly more super-diverse, the question of fair and effective representation becomes increasingly relevant. This paper explores who stood and who was elected to local office, in the three Auckland triennial local elections, following the 2010 amalgamation of the regions local authorities. It addresses the question of how representative the electoral candidates and elected members of local government in Auckland were of the diverse population they serve. A quantitative analysis of the gender and ethnicity of the Auckland Council candidates and elected members in 2013, 2016, and 2019 triennial elections was undertaken, and the gender and ethnicity compared with that of the Auckland population. Our findings show that under the two-tiered shared governance model established by the Local Government Act (Auckland Council) 2009, electoral candidates have become more ethnically and gender representative of Aucklanders at the local level, while at the regional level, divergence from predominantly New Zealand European, male local representatives is emerging, albeit with less pace. These findings warrant further investigation, but overall, the research presents a cautiously optimistic picture of Auckland local democracy in terms of increasing representational diversity. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=local%20government" title="local government">local government</a>, <a href="https://publications.waset.org/abstracts/search?q=representation" title=" representation"> representation</a>, <a href="https://publications.waset.org/abstracts/search?q=diversity" title=" diversity"> diversity</a>, <a href="https://publications.waset.org/abstracts/search?q=gender" title=" gender"> gender</a>, <a href="https://publications.waset.org/abstracts/search?q=ethnicity" title=" ethnicity"> ethnicity</a> </p> <a href="https://publications.waset.org/abstracts/143918/women-ethnic-minorities-and-electoral-success" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/143918.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">333</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">13</span> Language Use in Autobiographical Memory Transcripts as a Window into Attachment Style and Personality</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=McKenzie%20S.%20Braley">McKenzie S. Braley</a>, <a href="https://publications.waset.org/abstracts/search?q=Lesley%20Jessiman"> Lesley Jessiman</a> </p> <p class="card-text"><strong>Abstract:</strong></p> If language reveals internal psychological processing, then it is also likely that language use in autobiographical memory transcripts may be used as a window into attachment style and related personality features. The current study, therefore, examined the possible associations between attachment style, negative affectivity, social inhibition, and linguistic features extracted from autobiographical memory transcripts. Young adult participants (n = 61) filled out attachment and personality questionnaires, and orally reported a relationship-related memory. Memories were audio-recorded and later transcribed verbatim. Using a computerized linguistic extraction tool, positive affect words, negative affect words, and cognition words were extracted. Spearman’s rank correlation coefficients revealed that attachment anxiety was negatively correlated with cognition words (r2 = -0.26, p = 0.047) and that negative affectivity was negatively correlated with positive affect words (r2 = -0.32, p = 0.012). The findings suggest that attachment style and personality are associated with speech styles indicative of both emotionality and depth of processing. Because attachment styles, negative affectivity, and social inhibition are associated with poor mental health outcomes, analyses of key linguistics features in autobiographical memory narratives may provide reliable screening tools for mental wellbeing. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=attachment%20style" title="attachment style">attachment style</a>, <a href="https://publications.waset.org/abstracts/search?q=autobiographical%20memory" title=" autobiographical memory"> autobiographical memory</a>, <a href="https://publications.waset.org/abstracts/search?q=language" title=" language"> language</a>, <a href="https://publications.waset.org/abstracts/search?q=negative%20affectivity" title=" negative affectivity"> negative affectivity</a>, <a href="https://publications.waset.org/abstracts/search?q=social%20inhibition" title=" social inhibition"> social inhibition</a> </p> <a href="https://publications.waset.org/abstracts/95477/language-use-in-autobiographical-memory-transcripts-as-a-window-into-attachment-style-and-personality" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/95477.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">272</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">12</span> Philippine English: An Exploratory Mixed-Methods Inquiry on Digital Immigrants and Digital Natives' Variety</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Lesley%20Karen%20Penera">Lesley Karen Penera</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Despite the countless that has been drawn to investigate Philippine English for a myriad of reasons, none was known to have ventured on a probe of its grammatical features as used in a technology-driven linguistic landscape by two generations in the digital age. Propelled by the assumption of an emerging Philippine English variety, this paper determined the grammatical features that characterize the digital native-immigrants’ Philippine English. It also ascertained whether mistake or deviation instigated the use of the features, and established this variety’s level of comprehensibility. This exploratory mixed-methods inquiry employed some qualitative and quantitative data drawn from a social networking site, the digital native-immigrant group, and the comprehensibility-raters who were selected through non-random purposive sampling. The study yields 8 grammatical features, mostly deemed results of deviation, yet the texts characterized by such features were mostly rated with excellent comprehensibility. This substantiates some of the grammatical features identified in earlier studies, provides evidentiary proof that the digital groups’ Philippine English is not bound by the standard of syntactic accuracy and corroborates the assertion on language’s manipulability as an instrument fashioned to satisfy the users’ need for successful communication in actual instances for use of English past the walls of any university where the variety is cultivated. The same could also be rationalized by some respondents’ position on grammar and accuracy to be less vital than one’s facility to communicate effectively. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=comprehensibility" title="comprehensibility">comprehensibility</a>, <a href="https://publications.waset.org/abstracts/search?q=deviation" title=" deviation"> deviation</a>, <a href="https://publications.waset.org/abstracts/search?q=digital%20immigrants" title=" digital immigrants"> digital immigrants</a>, <a href="https://publications.waset.org/abstracts/search?q=digital%20natives" title=" digital natives"> digital natives</a>, <a href="https://publications.waset.org/abstracts/search?q=mistake" title=" mistake"> mistake</a>, <a href="https://publications.waset.org/abstracts/search?q=Philippine%20English%20variety" title=" Philippine English variety"> Philippine English variety</a> </p> <a href="https://publications.waset.org/abstracts/90970/philippine-english-an-exploratory-mixed-methods-inquiry-on-digital-immigrants-and-digital-natives-variety" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/90970.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">161</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">11</span> Design Practices, Policies and Guidelines towards Implementing Architectural Passive Cooling Strategies in Public Library Buildings in Temperate Climates </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Lesley%20Metibogun">Lesley Metibogun</a>, <a href="https://publications.waset.org/abstracts/search?q=Regan%20Potangaroa"> Regan Potangaroa</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Some existing sustainable public libraries in New Zealand now depend on air conditioning system for cooling. This seems completely contradictory to sustainable building initiatives. A sustainable building should be ‘self- sufficient’ and must aim at optimising the use of natural ventilation, wind and daylight and avoiding too much summer heat penetration into the building, to save energy consumption and enhance occupants’ comfort. This paper demonstrates that with appropriate architectural passive design input public libraries do not require air conditioning. Following a brief outline of how our dependence on air conditioning has spread over the full range of building types and climatic zones, this paper focuses on public libraries in temperate climates where passive cooling should be feasible for long periods of mild outside temperature. It was found that current design policies, regulations and guidelines and current building design practices militate passive cooling strategies. Perceived association with prestige, inflexibility of design process, rigid planning regulations and sustainability rating systems were identified as key factors forcing the need for air conditioning. Recommendations are made on how to further encourage development in this direction from the perspective of architectural design. This paper highlights how architectural passive cooling design strategies should be implemented in government initiated policies and regulations to develop a more sustainable public libraries. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=public%20library" title="public library">public library</a>, <a href="https://publications.waset.org/abstracts/search?q=sustainable%20design" title=" sustainable design"> sustainable design</a>, <a href="https://publications.waset.org/abstracts/search?q=temperate%20climate" title=" temperate climate"> temperate climate</a>, <a href="https://publications.waset.org/abstracts/search?q=passive%20cooling" title=" passive cooling"> passive cooling</a>, <a href="https://publications.waset.org/abstracts/search?q=air%20conditioning" title=" air conditioning"> air conditioning</a> </p> <a href="https://publications.waset.org/abstracts/75107/design-practices-policies-and-guidelines-towards-implementing-architectural-passive-cooling-strategies-in-public-library-buildings-in-temperate-climates" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/75107.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">249</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">10</span> Intrarenal Injection of Pentobarbital Sodium for Euthanasia in Cats: 131 Cases, 2010-2011</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Kathleen%20%20Cooney">Kathleen Cooney</a>, <a href="https://publications.waset.org/abstracts/search?q=Jennifer%20Coates"> Jennifer Coates</a>, <a href="https://publications.waset.org/abstracts/search?q=Lesley%20Leach"> Lesley Leach</a>, <a href="https://publications.waset.org/abstracts/search?q=Kristin%20Hrenchir"> Kristin Hrenchir</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The objective of this retrospective study was to determine whether intrarenal injection of pentobarbital sodium is a practicable method of euthanasia in client-owned cats. 131 Cats were anesthetized using a combination of tiletamine, zolazepam, and acepromazine given by of subcutaneous or intramuscular injection. Once an appropriate plane of anesthesia was reached, 6 ml of pentobarbital sodium was injected into either the left or right kidney. The patient’s age, sex, estimated weight, presenting condition, estimated dehydration level, palpable characteristics of the kidney pre and post injection, physical response of the cat, and time to cardiopulmonary arrest were recorded. Analysis of 131 records revealed that cats receiving an intrarenal injection of pentobarbital sodium had an average time to cardiopulmonary arrest of 1 minute. The great majority (79%) experienced cardiopulmonary arrest in less than one minute with the remainder experiencing cardiopulmonary arrest between 1 and 8 minutes of the injection. 95% of cats had no observable reaction to intrarenal injection other than cardiopulmonary arrest. In the 19% of cases where kidney swelling was not palpable upon injection, average time to cardiopulmonary arrest increased from 0.9 to 1.6 min. Conclusions and Clinical Relevance: Intrarenal injections of pentobarbital sodium are similar in effect to intravenous methods of euthanasia. Veterinarians who elect to use intrarenal injections can expect cardiopulmonary arrest to occur quickly in the majority of patients with few agonal reactions. Intrarenal injection of pentobarbital sodium in anesthetized cats has ideally suited for cases of owner observed euthanasia when obtaining intravenous access would difficult or disruptive. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=euthanasia" title="euthanasia">euthanasia</a>, <a href="https://publications.waset.org/abstracts/search?q=injection" title=" injection"> injection</a>, <a href="https://publications.waset.org/abstracts/search?q=intrarenal" title=" intrarenal"> intrarenal</a>, <a href="https://publications.waset.org/abstracts/search?q=pentobarbital%20sodium" title=" pentobarbital sodium"> pentobarbital sodium</a> </p> <a href="https://publications.waset.org/abstracts/79017/intrarenal-injection-of-pentobarbital-sodium-for-euthanasia-in-cats-131-cases-2010-2011" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/79017.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">343</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">9</span> Supplier Risk Management: A Multivariate Statistical Modelling and Portfolio Optimization Based Approach for Supplier Delivery Performance Development </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jiahui%20Yang">Jiahui Yang</a>, <a href="https://publications.waset.org/abstracts/search?q=John%20Quigley"> John Quigley</a>, <a href="https://publications.waset.org/abstracts/search?q=Lesley%20Walls"> Lesley Walls</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this paper, the authors develop a stochastic model regarding the investment in supplier delivery performance development from a buyer’s perspective. The authors propose a multivariate model through a Multinomial-Dirichlet distribution within an Empirical Bayesian inference framework, representing both the epistemic and aleatory uncertainties in deliveries. A closed form solution is obtained and the lower and upper bound for both optimal investment level and expected profit under uncertainty are derived. The theoretical properties provide decision makers with useful insights regarding supplier delivery performance improvement problems where multiple delivery statuses are involved. The authors also extend the model from a single supplier investment into a supplier portfolio, using a Lagrangian method to obtain a theoretical expression for an optimal investment level and overall expected profit. The model enables a buyer to know how the marginal expected profit/investment level of each supplier changes with respect to the budget and which supplier should be invested in when additional budget is available. An application of this model is illustrated in a simulation study. Overall, the main contribution of this study is to provide an optimal investment decision making framework for supplier development, taking into account multiple delivery statuses as well as multiple projects. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=decision%20making" title="decision making">decision making</a>, <a href="https://publications.waset.org/abstracts/search?q=empirical%20bayesian" title=" empirical bayesian"> empirical bayesian</a>, <a href="https://publications.waset.org/abstracts/search?q=portfolio%20optimization" title=" portfolio optimization"> portfolio optimization</a>, <a href="https://publications.waset.org/abstracts/search?q=supplier%20development" title=" supplier development"> supplier development</a>, <a href="https://publications.waset.org/abstracts/search?q=supply%20chain%20management" title=" supply chain management"> supply chain management</a> </p> <a href="https://publications.waset.org/abstracts/89731/supplier-risk-management-a-multivariate-statistical-modelling-and-portfolio-optimization-based-approach-for-supplier-delivery-performance-development" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/89731.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">288</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">8</span> Innovations in International Trauma Education: An Evaluation of Learning Outcomes and Community Impact of a Guyanese trauma Training Graduate Program</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jeffrey%20Ansloos">Jeffrey Ansloos</a> </p> <p class="card-text"><strong>Abstract:</strong></p> International trauma education in low and emerging economies requires innovative methods for capacity building in existing social service infrastructures. This study details the findings of a program evaluation used to assess the learning outcomes and community impact of an international trauma-focused graduate degree program in Guyana. Through a collaborative partnership between Lesley University, the Government of Guyana, and UNICEF, a 2-year low-residency masters degree graduate program in trauma-focused assessment, intervention, and treatment was piloted with a cohort of Guyanese mental health professionals. Through an analytical review of the program development, as well as qualitative data analysis of participant interviews and focus-groups, this study will address the efficacy of the programming in terms of preparedness of professionals to understand, evaluate and implement trauma-informed practices across various child, youth, and family mental health service settings. Strengths and limitations of this international trauma-education delivery model will be discussed with particular emphasis on the role of capacity-building interventions, community-based participatory curriculum development, innovative technological delivery platforms, and interdisciplinary education. Implications for further research and subsequent program development will be discussed. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=mental%20health%20promotion" title="mental health promotion">mental health promotion</a>, <a href="https://publications.waset.org/abstracts/search?q=global%20health%20promotion" title=" global health promotion"> global health promotion</a>, <a href="https://publications.waset.org/abstracts/search?q=trauma%20education" title=" trauma education"> trauma education</a>, <a href="https://publications.waset.org/abstracts/search?q=innovations%20in%20education" title=" innovations in education"> innovations in education</a>, <a href="https://publications.waset.org/abstracts/search?q=child" title=" child"> child</a>, <a href="https://publications.waset.org/abstracts/search?q=youth" title=" youth"> youth</a>, <a href="https://publications.waset.org/abstracts/search?q=mental%20health%20education" title=" mental health education"> mental health education</a> </p> <a href="https://publications.waset.org/abstracts/31652/innovations-in-international-trauma-education-an-evaluation-of-learning-outcomes-and-community-impact-of-a-guyanese-trauma-training-graduate-program" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/31652.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">367</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7</span> Interrelationship of Socio-Demographic Factors, Health Belief Dimensions and Compliance to Measles Vaccination among Filipino Mothers</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Beryl%20Rene%20R.%20Lopez">Beryl Rene R. Lopez</a>, <a href="https://publications.waset.org/abstracts/search?q=Lesley%20Anne%20M.%20Lipat"> Lesley Anne M. Lipat</a>, <a href="https://publications.waset.org/abstracts/search?q=Rhogene%20Barbette%20C.%20Lirio"> Rhogene Barbette C. Lirio</a>, <a href="https://publications.waset.org/abstracts/search?q=Laurice%20Joy%20H.%20Llanes"> Laurice Joy H. Llanes</a>, <a href="https://publications.waset.org/abstracts/search?q=Karl%20Philippe%20M.%20Llapitan"> Karl Philippe M. Llapitan</a>, <a href="https://publications.waset.org/abstracts/search?q=Einstein%20James%20R.%20Lopez"> Einstein James R. Lopez</a>, <a href="https://publications.waset.org/abstracts/search?q=Socorro%20S.%20GuanHing"> Socorro S. GuanHing</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Measles remain as one of the most common childhood diseases despite the availability of the vaccine that is safe and cost-effective. Because of morbidity and mortality associated with the recent measles outbreak in the Philippines, there is an increasing concern from the health care professionals. Objective: The purpose of this study is to determine the relationship between the compliance of Filipino mothers to measles vaccination and their health beliefs when grouped according to the given socio-demographic factors using a researcher-made questionnaire. Research Methodology: This research utilized the descriptive-correlational research design. With the use of purposive sampling technique, the study involved 200 Filipino mothers aged 18 years old and above excluding those who are healthcare professionals with children aged 2-3 years old with either urban or rural as their settlements. Pre-testing was done prior to the actual data gathering. A questionnaire composed of 26 items involving socio-demographic, compliance, and health beliefs was distributed to the sample population. Statistical analysis was done with the use of Exploratory Factor Analysis (EFA) for the first research question and Structural Equation Model (SEM) for the second research question. Results: Four dimensions were generated with the use of EFA namely: Vulnerability-Oriented Beliefs (VOB), Knowledge-Oriented Beliefs (KOB), Accessibility-Oriented Beliefs (AOB), and Outcomes-Oriented Beliefs (OOB). These were then correlated with the mothers’ socio-demographic factors (age, educational attainment, the area of residence, the number of children, and family income) and their compliance to the measles vaccination schedule. Results showed significant and direct relationships between area of residence and compliance, family income and compliance, KOB and compliance, education and KOB, KOB and VOB, KOB and OOB, AOB and KOB, AOB and OOB, AOB and VOB, and lastly, OOB and VOB. Conclusion: The Knowledge – Oriented Belief dimension greatly influence compliance to measles vaccination. Other determinants of compliance like the area of residence, educational attainment, and family income significantly increase the Filipino mothers’ likelihood of compliance to measles vaccination, which have implications to health education. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=socio-demographic" title="socio-demographic">socio-demographic</a>, <a href="https://publications.waset.org/abstracts/search?q=health%20beliefs" title=" health beliefs"> health beliefs</a>, <a href="https://publications.waset.org/abstracts/search?q=compliance" title=" compliance"> compliance</a>, <a href="https://publications.waset.org/abstracts/search?q=measles%20vaccination" title=" measles vaccination"> measles vaccination</a> </p> <a href="https://publications.waset.org/abstracts/21315/interrelationship-of-socio-demographic-factors-health-belief-dimensions-and-compliance-to-measles-vaccination-among-filipino-mothers" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/21315.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">375</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">6</span> Protecting the Health of Astronauts: Enhancing Occupational Health Monitoring and Surveillance for Former NASA Astronauts to Understand Long-Term Outcomes of Spaceflight-Related Exposures</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Meredith%20Rossi">Meredith Rossi</a>, <a href="https://publications.waset.org/abstracts/search?q=Lesley%20Lee"> Lesley Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Mary%20Wear"> Mary Wear</a>, <a href="https://publications.waset.org/abstracts/search?q=Mary%20Van%20Baalen"> Mary Van Baalen</a>, <a href="https://publications.waset.org/abstracts/search?q=Bradley%20Rhodes"> Bradley Rhodes</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The astronaut community is unique, and may be disproportionately exposed to occupational hazards not commonly seen in other communities. The extent to which the demands of the astronaut occupation and exposure to spaceflight-related hazards affect the health of the astronaut population over the life course is not completely known. A better understanding of the individual, population, and mission impacts of astronaut occupational exposures is critical to providing clinical care, targeting occupational surveillance efforts, and planning for future space exploration. The ability to characterize the risk of latent health conditions is a significant component of this understanding. Provision of health screening services to active and former astronauts ensures individual, mission, and community health and safety. Currently, the NASA-Johnson Space Center (JSC) Flight Medicine Clinic (FMC) provides extensive medical monitoring to active astronauts throughout their careers. Upon retirement, astronauts may voluntarily return to the JSC FMC for an annual preventive exam. However, current retiree monitoring includes only selected screening tests, representing an opportunity for augmentation. The potential long-term health effects of spaceflight demand an expanded framework of testing for former astronauts. The need is two-fold: screening tests widely recommended for other aging populations are necessary to rule out conditions resulting from the natural aging process (e.g., colonoscopy, mammography); and expanded monitoring will increase NASA’s ability to better characterize conditions resulting from astronaut occupational exposures. To meet this need, NASA has begun an extensive exploration of the overall approach, cost, and policy implications of expanding the medical monitoring of former NASA astronauts under the Astronaut Occupational Health program. Increasing the breadth of monitoring services will ultimately enrich the existing evidence base of occupational health risks to astronauts. Such an expansion would therefore improve the understanding of the health of the astronaut population as a whole, and the ability to identify, mitigate, and manage such risks in preparation for deep space exploration missions. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=astronaut" title="astronaut">astronaut</a>, <a href="https://publications.waset.org/abstracts/search?q=long-term%20health" title=" long-term health"> long-term health</a>, <a href="https://publications.waset.org/abstracts/search?q=NASA" title=" NASA"> NASA</a>, <a href="https://publications.waset.org/abstracts/search?q=occupational%20health" title=" occupational health"> occupational health</a>, <a href="https://publications.waset.org/abstracts/search?q=surveillance" title=" surveillance"> surveillance</a> </p> <a href="https://publications.waset.org/abstracts/58163/protecting-the-health-of-astronauts-enhancing-occupational-health-monitoring-and-surveillance-for-former-nasa-astronauts-to-understand-long-term-outcomes-of-spaceflight-related-exposures" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/58163.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">533</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5</span> Internet-Delivered Cognitive Behaviour Therapy for Depression Comorbid with Diabetes: Preliminary Findings</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Lisa%20Robins">Lisa Robins</a>, <a href="https://publications.waset.org/abstracts/search?q=Jill%20Newby"> Jill Newby</a>, <a href="https://publications.waset.org/abstracts/search?q=Kay%20Wilhelm"> Kay Wilhelm</a>, <a href="https://publications.waset.org/abstracts/search?q=Therese%20Fletcher"> Therese Fletcher</a>, <a href="https://publications.waset.org/abstracts/search?q=Jessica%20Smith"> Jessica Smith</a>, <a href="https://publications.waset.org/abstracts/search?q=Trevor%20Ma"> Trevor Ma</a>, <a href="https://publications.waset.org/abstracts/search?q=Adam%20Finch"> Adam Finch</a>, <a href="https://publications.waset.org/abstracts/search?q=Lesley%20Campbell"> Lesley Campbell</a>, <a href="https://publications.waset.org/abstracts/search?q=Jerry%20Greenfield"> Jerry Greenfield</a>, <a href="https://publications.waset.org/abstracts/search?q=Gavin%20Andrews"> Gavin Andrews</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background:Depression treatment for people living with depression comorbid with diabetes is of critical importance for improving quality of life and diabetes self-management, however depression remains under-recognised and under-treated in this population. Cost—effective and accessible forms of depression treatment that can enhance the delivery of mental health services in routine diabetes care are needed. Provision of internet-delivered Cognitive Behaviour Therapy (iCBT) provides a promising way to deliver effective depression treatment to people with diabetes. Aims:To explore the outcomes of the clinician assisted iCBT program for people with comorbid Major Depressive Disorder (MDD) and diabetes compared to those who remain under usual care. The main hypotheses are that: (1) Participants in the treatment group would show a significant improvement on disorder specific measures (Patient Health Questionnaire; PHQ-9) relative to those in the control group; (2) Participants in the treatment group will show a decrease in diabetes-related distress relative to those in the control group. This study will also examine: (1) the effect of iCBT for MDD on disability (as measured by the SF-12 and SDS), general distress (as measured by the K10), (2) the feasibility of these treatments in terms of acceptability to diabetes patients and practicality for clinicians (as measured by the Credibility/Expectancy Questionnaire; CEQ). We hypothesise that associated disability, and general distress will reduce, and that patients with comorbid MDD and diabetes will rate the program as acceptable. Method:Recruit 100 people with MDD comorbid with diabetes (either Type 1 or Type 2), and randomly allocate to: iCBT (over 10 weeks) or treatment as usual (TAU) for 10 weeks, then iCBT. Measure pre- and post-intervention MDD severity, anxiety, diabetes-related distress, distress, disability, HbA1c, lifestyle, adherence, satisfaction with clinicians input and the treatment. Results:Preliminary results comparing MDD symptom levels, anxiety, diabetes-specific distress, distress, disability, HbA1c levels, and lifestyle factors from baseline to conclusion of treatment will be presented, as well as data on adherence to the lessons, homework downloads, satisfaction with the clinician's input and satisfaction with the mode of treatment generally. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cognitive%20behaviour%20therapy" title="cognitive behaviour therapy">cognitive behaviour therapy</a>, <a href="https://publications.waset.org/abstracts/search?q=depression" title=" depression"> depression</a>, <a href="https://publications.waset.org/abstracts/search?q=diabetes" title=" diabetes"> diabetes</a>, <a href="https://publications.waset.org/abstracts/search?q=internet" title=" internet"> internet</a> </p> <a href="https://publications.waset.org/abstracts/24273/internet-delivered-cognitive-behaviour-therapy-for-depression-comorbid-with-diabetes-preliminary-findings" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/24273.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">489</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4</span> Analytical Validity Of A Tech Transfer Solution To Internalize Genetic Testing</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Lesley%20Northrop">Lesley Northrop</a>, <a href="https://publications.waset.org/abstracts/search?q=Justin%20DeGrazia"> Justin DeGrazia</a>, <a href="https://publications.waset.org/abstracts/search?q=Jessica%20Greenwood"> Jessica Greenwood</a> </p> <p class="card-text"><strong>Abstract:</strong></p> ASPIRA Labs now offers an en-suit and ready-to-implement technology transfer solution to enable labs and hospitals that lack the resources to build it themselves to offer in-house genetic testing. This unique platform employs a patented Molecular Inversion Probe (MIP) technology that combines the specificity of a hybrid capture protocol with the ease of an amplicon-based protocol and utilizes an advanced bioinformatics analysis pipeline based on machine learning. To demonstrate its efficacy, two independent genetic tests were validated on this technology transfer platform: expanded carrier screening (ECS) and hereditary cancer testing (HC). The analytical performance of ECS and HC was validated separately in a blinded manner for calling three different types of variants: SNVs, short indels (typically, <50 bp), and large indels/CNVs defined as multi-exonic del/dup events. The reference set was constructed using samples from Coriell Institute, an external clinical genetic testing laboratory, Maine Molecular Quality Controls Inc. (MMQCI), SeraCare and GIAB Consortium. Overall, the analytical performance showed a sensitivity and specificity of >99.4% for both ECS and HC in detecting SNVs. For indels, both tests reported specificity of 100%, and ECS demonstrated a sensitivity of 100%, whereas HC exhibited a sensitivity of 96.5%. The bioinformatics pipeline also correctly called all reference CNV events resulting in a sensitivity of 100% for both tests. No additional calls were made in the HC panel, leading to a perfect performance (specificity and F-measure of 100%). In the carrier panel, however, three additional positive calls were made outside the reference set. Two of these calls were confirmed using an orthogonal method and were re-classified as true positives leaving only one false positive. The pipeline also correctly identified all challenging carrier statuses, such as positive cases for spinal muscular atrophy and alpha-thalassemia, resulting in 100% sensitivity. After confirmation of additional positive calls via long-range PCR and MLPA, specificity for such cases was estimated at 99%. These performance metrics demonstrate that this tech-transfer solution can be confidently internalized by clinical labs and hospitals to offer mainstream ECS and HC as part of their test catalog, substantially increasing access to quality germline genetic testing for labs of all sizes and resources levels. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=clinical%20genetics" title="clinical genetics">clinical genetics</a>, <a href="https://publications.waset.org/abstracts/search?q=genetic%20testing" title=" genetic testing"> genetic testing</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20genetics" title=" molecular genetics"> molecular genetics</a>, <a href="https://publications.waset.org/abstracts/search?q=technology%20transfer" title=" technology transfer"> technology transfer</a> </p> <a href="https://publications.waset.org/abstracts/139070/analytical-validity-of-a-tech-transfer-solution-to-internalize-genetic-testing" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/139070.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">178</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3</span> The Diagnostic Utility and Sensitivity of the Xpert® MTB/RIF Assay in Diagnosing Mycobacterium tuberculosis in Bone Marrow Aspirate Specimens</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nadhiya%20N.%20Subramony">Nadhiya N. Subramony</a>, <a href="https://publications.waset.org/abstracts/search?q=Jenifer%20Vaughan"> Jenifer Vaughan</a>, <a href="https://publications.waset.org/abstracts/search?q=Lesley%20E.%20Scott"> Lesley E. Scott</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In South Africa, the World Health Organisation estimated 454000 new cases of Mycobacterium tuberculosis (M.tb) infection (MTB) in 2015. Disseminated tuberculosis arises from the haematogenous spread and seeding of the bacilli in extrapulmonary sites. The gold standard for the detection of MTB in bone marrow is TB culture which has an average turnaround time of 6 weeks. Histological examinations of trephine biopsies to diagnose MTB also have a time delay owing mainly to the 5-7 day processing period prior to microscopic examination. Adding to the diagnostic delay is the non-specific nature of granulomatous inflammation which is the hallmark of MTB involvement of the bone marrow. A Ziehl-Neelson stain (which highlights acid-fast bacilli) is therefore mandatory to confirm the diagnosis but can take up to 3 days for processing and evaluation. Owing to this delay in diagnosis, many patients are lost to follow up or remain untreated whilst results are awaited, thus encouraging the spread of undiagnosed TB. The Xpert® MTB/RIF (Cepheid, Sunnyvale, CA) is the molecular test used in the South African national TB program as the initial diagnostic test for pulmonary TB. This study investigates the optimisation and performance of the Xpert® MTB/RIF on bone marrow aspirate specimens (BMA), a first since the introduction of the assay in the diagnosis of extrapulmonary TB. BMA received for immunophenotypic analysis as part of the investigation into disseminated MTB or in the evaluation of cytopenias in immunocompromised patients were used. Processing BMA on the Xpert® MTB/RIF was optimised to ensure bone marrow in EDTA and heparin did not inhibit the PCR reaction. Inactivated M.tb was spiked into the clinical bone marrow specimen and distilled water (as a control). A volume of 500mcl and an incubation time of 15 minutes with sample reagent were investigated as the processing protocol. A total of 135 BMA specimens had sufficient residual volume for Xpert® MTB/RIF testing however 22 specimens (16.3%) were not included in the final statistical analysis as an adequate trephine biopsy and/or TB culture was not available. Xpert® MTB/RIF testing was not affected by BMA material in the presence of heparin or EDTA, but the overall detection of MTB in BMA was low compared to histology and culture. Sensitivity of the Xpert® MTB/RIF compared to both histology and culture was 8.7% (95% confidence interval (CI): 1.07-28.04%) and sensitivity compared to histology only was 11.1% (95% CI: 1.38-34.7%). Specificity of the Xpert® MTB/RIF was 98.9% (95% CI: 93.9-99.7%). Although the Xpert® MTB/RIF generates a faster result than histology and TB culture and is less expensive than culture and drug susceptibility testing, the low sensitivity of the Xpert® MTB/RIF precludes its use for the diagnosis of MTB in bone marrow aspirate specimens and warrants alternative/additional testing to optimise the assay. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=bone%20marrow%20aspirate" title="bone marrow aspirate ">bone marrow aspirate </a>, <a href="https://publications.waset.org/abstracts/search?q=extrapulmonary%20TB" title=" extrapulmonary TB"> extrapulmonary TB</a>, <a href="https://publications.waset.org/abstracts/search?q=low%20sensitivity" title=" low sensitivity"> low sensitivity</a>, <a href="https://publications.waset.org/abstracts/search?q=Xpert%C2%AE%20MTB%2FRIF" title=" Xpert® MTB/RIF"> Xpert® MTB/RIF</a> </p> <a href="https://publications.waset.org/abstracts/82583/the-diagnostic-utility-and-sensitivity-of-the-xpert-mtbrif-assay-in-diagnosing-mycobacterium-tuberculosis-in-bone-marrow-aspirate-specimens" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/82583.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">172</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Combined Treatment of Estrogen-Receptor Positive Breast Microtumors with 4-Hydroxytamoxifen and Novel Non-Steroidal Diethyl Stilbestrol-Like Analog Produces Enhanced Preclinical Treatment Response and Decreased Drug Resistance</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sarah%20Crawford">Sarah Crawford</a>, <a href="https://publications.waset.org/abstracts/search?q=Gerry%20Lesley"> Gerry Lesley</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This research is a pre-clinical assessment of anti-cancer effects of novel non-steroidal diethyl stilbestrol-like estrogen analogs in estrogen-receptor positive/ progesterone-receptor positive human breast cancer microtumors of MCF 7 cell line. Tamoxifen analog formulation (Tam A1) was used as a single agent or in combination with therapeutic concentrations of 4-hydroxytamoxifen, currently used as a long-term treatment for the prevention of breast cancer recurrence in women with estrogen receptor positive/ progesterone receptor positive malignancies. At concentrations ranging from 30-50 microM, Tam A1 induced microtumor disaggregation and cell death. Incremental cytotoxic effects correlated with increasing concentrations of Tam A1. Live tumor microscopy showed that microtumos displayed diffuse borders and substrate-attached cells were rounded-up and poorly adherent. A complete cytotoxic effect was observed using 40-50 microM Tam A1 with time course kinetics similar to 4-hydroxytamoxifen. Combined treatment with TamA1 (30-50 microM) and 4-hydroxytamoxifen (10-15 microM) induced a highly cytotoxic, synergistic combined treatment response that was more rapid and complete than using 4-hydroxytamoxifen as a single agent therapeutic. Microtumors completely dispersed or formed necrotic foci indicating a highly cytotoxic combined treatment response. Moreover, breast cancer microtumors treated with both 4-hydroxytamoxifen and Tam A1 displayed lower levels of long-term post-treatment regrowth, a critical parameter of primary drug resistance, than observed for 4-hydroxytamoxifen when used as a single agent therapeutic. Tumor regrowth at 6 weeks post-treatment with either single agent 4-hydroxy tamoxifen, Tam A1 or a combined treatment was assessed for the development of drug resistance. Breast cancer cells treated with both 4-hydroxytamoxifen and Tam A1 displayed significantly lower levels of post-treatment regrowth, indicative of decreased drug resistance, than observed for either single treatment modality. The preclinical data suggest that combined treatment involving the use of tamoxifen analogs may be a novel clinical approach for long-term maintenance therapy in patients with estrogen-receptor positive/progesterone-receptor positive breast cancer receiving hormonal therapy to prevent disease recurrence. Detailed data on time-course, IC50 and tumor regrowth assays post- treatment as well as a proposed mechanism of action to account for observed synergistic drug effects will be presented. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=4-hydroxytamoxifen" title="4-hydroxytamoxifen">4-hydroxytamoxifen</a>, <a href="https://publications.waset.org/abstracts/search?q=tamoxifen%20analog" title=" tamoxifen analog"> tamoxifen analog</a>, <a href="https://publications.waset.org/abstracts/search?q=drug-resistance" title=" drug-resistance"> drug-resistance</a>, <a href="https://publications.waset.org/abstracts/search?q=microtumors" title=" microtumors"> microtumors</a> </p> <a href="https://publications.waset.org/abstracts/171941/combined-treatment-of-estrogen-receptor-positive-breast-microtumors-with-4-hydroxytamoxifen-and-novel-non-steroidal-diethyl-stilbestrol-like-analog-produces-enhanced-preclinical-treatment-response-and-decreased-drug-resistance" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/171941.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">68</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Leveraging Power BI for Advanced Geotechnical Data Analysis and Visualization in Mining Projects</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Elaheh%20Talebi">Elaheh Talebi</a>, <a href="https://publications.waset.org/abstracts/search?q=Fariba%20Yavari"> Fariba Yavari</a>, <a href="https://publications.waset.org/abstracts/search?q=Lucy%20Philip"> Lucy Philip</a>, <a href="https://publications.waset.org/abstracts/search?q=Lesley%20Town"> Lesley Town</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The mining industry generates vast amounts of data, necessitating robust data management systems and advanced analytics tools to achieve better decision-making processes in the development of mining production and maintaining safety. This paper highlights the advantages of Power BI, a powerful intelligence tool, over traditional Excel-based approaches for effectively managing and harnessing mining data. Power BI enables professionals to connect and integrate multiple data sources, ensuring real-time access to up-to-date information. Its interactive visualizations and dashboards offer an intuitive interface for exploring and analyzing geotechnical data. Advanced analytics is a collection of data analysis techniques to improve decision-making. Leveraging some of the most complex techniques in data science, advanced analytics is used to do everything from detecting data errors and ensuring data accuracy to directing the development of future project phases. However, while Power BI is a robust tool, specific visualizations required by geotechnical engineers may have limitations. This paper studies the capability to use Python or R programming within the Power BI dashboard to enable advanced analytics, additional functionalities, and customized visualizations. This dashboard provides comprehensive tools for analyzing and visualizing key geotechnical data metrics, including spatial representation on maps, field and lab test results, and subsurface rock and soil characteristics. Advanced visualizations like borehole logs and Stereonet were implemented using Python programming within the Power BI dashboard, enhancing the understanding and communication of geotechnical information. Moreover, the dashboard's flexibility allows for the incorporation of additional data and visualizations based on the project scope and available data, such as pit design, rock fall analyses, rock mass characterization, and drone data. This further enhances the dashboard's usefulness in future projects, including operation, development, closure, and rehabilitation phases. Additionally, this helps in minimizing the necessity of utilizing multiple software programs in projects. This geotechnical dashboard in Power BI serves as a user-friendly solution for analyzing, visualizing, and communicating both new and historical geotechnical data, aiding in informed decision-making and efficient project management throughout various project stages. Its ability to generate dynamic reports and share them with clients in a collaborative manner further enhances decision-making processes and facilitates effective communication within geotechnical projects in the mining industry. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=geotechnical%20data%20analysis" title="geotechnical data analysis">geotechnical data analysis</a>, <a href="https://publications.waset.org/abstracts/search?q=power%20BI" title=" power BI"> power BI</a>, <a href="https://publications.waset.org/abstracts/search?q=visualization" title=" visualization"> visualization</a>, <a href="https://publications.waset.org/abstracts/search?q=decision-making" title=" decision-making"> decision-making</a>, <a href="https://publications.waset.org/abstracts/search?q=mining%20industry" title=" mining industry"> mining industry</a> </p> <a href="https://publications.waset.org/abstracts/168956/leveraging-power-bi-for-advanced-geotechnical-data-analysis-and-visualization-in-mining-projects" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/168956.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">92</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational anniversary</a></li> </ul> 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