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MD, PhD</h3> <p class="profile__title" itemprop="jobTitle">Director, Center for the Study of Inflammatory Bowel Disease </br> Kurt J. Isselbacher Professor of Medicine in the Field of Gastroenterology, Harvard Medical School</p> </div> <p class="profile__image"> <img alt="" itemprop="image" srcset="/assets/images/contributors/xavier_ramnik_advances.png, /assets/images/contributors/xavier_ramnik_advances_2x.png 2x" src="/assets/images/contributors/xavier_ramnik_advances.png"> </p> </div> </div> </aside> <div class="layout-columns__main -padding--vertical -padding--horizontal" dcrname ="iwDCR0_280834"> <div class="layout-columns__main__content"> <h2 class="heading-h4">Posts by Ramnik Joseph Xavier, MD, PhD</h2> <ul class="content-tease__list"> <li class="content-tease__item"> <div class="content-tease" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/digestive-health/journal.aspx?id=2641" itemprop="url"> Cholesterol-reducing Gut Bacteria Might Lower Heart Disease Risk</a> </h3> <p itemprop="description"> <p>Ramnik J. Xavier, MD, PhD, Chenhao Li, PhD, Martin Stra啪ar, PhD, and colleagues have found that cholesterol metabolism is an important property of certain gut bacteria, Oscillibacter, with potential benefits for lipid homeostasis and cardiovascular health.</p></p> <p class="content-tease__related"> <a href="/cardiovascular/specialty.aspx?id=1002" itemprop="relatedLink">Cardiovascular</a>, <a href="/digestive-health/specialty.aspx?id=1007" itemprop="relatedLink">Digestive Health</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2024-08-05" itemprop="datePublished">August 5, 2024</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/digestive-health/journal.aspx?id=2627" itemprop="url"> No Unique Microbiome Detected in Pancreatic Cyst Fluid</a> </h3> <p itemprop="description"> <p><span>Mass General researchers and colleagues investigated claims that pancreatic cyst fluid harbors a distinct microbiome, but they didn't uncover one difference from the microbiome signature of negative controls, supporting the traditional view of the pancreas as a sterile environment.</span></p></p> <p class="content-tease__related"> <a href="/digestive-health/specialty.aspx?id=1007" itemprop="relatedLink">Digestive Health</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2024-05-28" itemprop="datePublished">May 28, 2024</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/digestive-health/journal.aspx?id=2549" itemprop="url"> Host Factors Identified That Regulate Latency of Mycobacterium tuberculosis</a> </h3> <p itemprop="description"> <p><span>Ramnik J. Xavier, MD, PhD, Haroon Kalam, PhD, and colleagues have identified the host transcriptome involved in various phenotypic states of Mycobacterium tuberculosis (Mtb) infection of macrophages and have pinpointed MMGT1–GPR156 signaling as a regulator of the lipid droplet formation that helps latent Mtb survive.</span></p></p> <p class="content-tease__related"> <a href="/digestive-health/specialty.aspx?id=1007" itemprop="relatedLink">Digestive Health</a>, <a href="/pulmonary/specialty.aspx?id=1012" itemprop="relatedLink">Pulmonary and Critical Care</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2023-11-10" itemprop="datePublished">November 10, 2023</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/digestive-health/journal.aspx?id=2465" itemprop="url"> Single-Cell Map of Crohn's Disease Provides New Directions for Drug Development</a> </h3> <p itemprop="description"> <p><span>Ramnik J. Xavier, MD, PhD, Lingjia Kong, PhD, and colleagues have produced the largest single-cell resource for studying Crohn's disease. This atlas provides unprecedented detail about cellular and transcriptomic changes that are distinct between the small and large intestines.</span></p></p> <p class="content-tease__related"> <a href="/digestive-health/specialty.aspx?id=1007" itemprop="relatedLink">Digestive Health</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2023-04-21" itemprop="datePublished">April 21, 2023</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/digestive-health/journal.aspx?id=2192" itemprop="url"> Multi-omics Approach Detects Gut Microbiome鈥搈ediated Metabolism Effects on Immunity</a> </h3> <p itemprop="description"> <p><span>Using a multi-omics approach to compare rural and urban Tanzanian populations, researchers at Massachusetts General Hospital identified 34 gut microbial factors and two metabolism pathways that modulate host immune responses.</span></p></p> <p class="content-tease__related"> <a href="/digestive-health/specialty.aspx?id=1007" itemprop="relatedLink">Digestive Health</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2022-04-06" itemprop="datePublished">April 6, 2022</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/digestive-health/journal.aspx?id=2182" itemprop="url"> Insight into How Human Cells Fight Bacteria鈥攁nd How Bacteria Fight Back</a> </h3> <p itemprop="description"> <p><span>Researchers at Massachusetts General Hospital have identified SAC1, a transmembrane lipid phosphatase, as a key regulator of xenophagy-directed bacterial clearance and show that SteA, a Salmonella-secreted effector protein, supp</span>orts intracellular replication.</p></p> <p class="content-tease__related"> <a href="/digestive-health/specialty.aspx?id=1007" itemprop="relatedLink">Digestive Health</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2022-03-30" itemprop="datePublished">March 30, 2022</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/digestive-health/journal.aspx?id=1471" itemprop="url"> Electronic Health Records Can Be Used to Validate Genetic Determinants of Treatment Response in IBD</a> </h3> <p itemprop="description"> <p> <p> <p>For patients with inflammatory bowel disease, narrative text in electronic health records was successfully used to validate associations between genetic risk scores and response to tumor necrosis factor inhibitors—a potential boon to identifying biomarkers of response to different drug classes.</p> <p></p> <p></p> <p></p> <p></p> <p></p> </p> </p></p> <p class="content-tease__related"> <a href="/digestive-health/specialty.aspx?id=1007" itemprop="relatedLink">Digestive Health</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2020-02-10" itemprop="datePublished">February 10, 2020</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/digestive-health/journal.aspx?id=1383" itemprop="url"> IBD Multiomics Database May Be Rich Source of New Treatment Targets</a> </h3> <p itemprop="description"> <p>Gastroenterologists at Massachusetts General Hospital are part of the Integrative Human Microbiome Project, which recently cataloged numerous molecular features of the gut microbiome that are implicated in inflammatory bowel disease.</p></p> <p class="content-tease__related"> <a href="/digestive-health/specialty.aspx?id=1007" itemprop="relatedLink">Digestive Health</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2019-10-14" itemprop="datePublished">October 14, 2019</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/digestive-health/article.aspx?id=1090" itemprop="url"> Identifying the Significance of Microbiome Diversity</a> </h3> <p itemprop="description"> <p>The Center for the Study of IBD at Massachusetts General Hospital is leading research to understand how the microbiome influences health and disease.</p></p> <p class="content-tease__related"> <a href="/digestive-health/specialty.aspx?id=1007" itemprop="relatedLink">Digestive Health</a> </p> <p class="content-metadata"> <span class="content-metadata__media -article">Article</span> <time class="date" datetime="2019-04-19" itemprop="datePublished">April 19, 2019</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/digestive-health/journal.aspx?id=1248" itemprop="url"> Discovering the Role of C1orf106 in Patients with IBD</a> </h3> <p itemprop="description"> <p>C1orf106 is a known susceptibility gene for inflammatory bowel disease, and now Massachusetts General researchers have identified its role: it "fine tunes" the integrity of the intestinal epithelial barrier.</p></p> <p class="content-tease__related"> <a href="/digestive-health/specialty.aspx?id=1007" itemprop="relatedLink">Digestive Health</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2019-03-15" itemprop="datePublished">March 15, 2019</time> </p> </div> </li> </ul> </div> </div> </section> <section class="-padding--vertical -padding--horizontal"> <div class="content-container -width--medium -centered"> <h2>Biography</h2> <p> <ul><li>Elected Member, American Association of Physicians</li><li>Senior Associate Member, Broad Institute of MIT and Harvard</li><li>Principal Investigator, Center for Computational and Integrative Biology</li></ul></p> <p class="fat-link__wrapper u-text-right"> <a class="fat-link -caret -large" href="https://www.massgeneral.org/doctors/16452/Ramnik-Xavier">View full profile</a> </p> </div> </section> <div class="content-container -width--xwide -centered specialty-block__wrapper" id="specialty-block"> <style> #specialty-block .specialty-block__image { /* 540px */ background-image: url(/assets/raw/specialty-block/subscription_callout_digestive-health_advances1x.jpg); } only screen and (-webkit-min-device-pixel-ratio: 2), only screen 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