ENZYME - 2.7.1.171 protein-fructosamine 3-kinase

<!DOCTYPE html> <html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" prefix="bioschema: https://bioschemas.org/"> <head> <meta http-equiv="Content-Type" content="text/html;charset=iso-8859-1">  <meta name="viewport" content="width=device-width, initial-scale=1.0">  <script type="application/ld+json"> { "@context": [ "https://schema.org/" ], "@type": "Organization", "url": "https://enzyme.expasy.org", "name": "ENZYME", "logo": "https://enzyme.expasy.org/images/expasy_logos/Expasy_logo_base_addon.svg", "memberof": { "@type": "NGO", "name": "SIB Swiss Institute of Bioinformatics", "url": "https://sib.swiss/" }, "parentOrganization": { "@type": "Organization", "name": "Expasy", "url": "https://www.expasy.org/" } } </script>  <script type="text/javascript" src="/js/jquery.min.js"></script> <script type="text/javascript" src="/js/main.js"></script> <link rel="stylesheet" href="/css/normalize.css?v=1.1" type="text/css" media="screen" charset="utf-8"> <link rel="stylesheet" href="/css/expasy_geneva.css?v=1.1" type="text/css" charset="utf-8">  <title>ENZYME - 2.7.1.171 protein-fructosamine 3-kinase</title> </head> <body class="enzyme" typeof="schema:WebPage">  <header class="header-grid"> <div class="header-elmt"> <img alt="Expasy logo" src="/images/expasy_logos/Expasy_logo_base_addon.svg"> </div> <h4 class="header-elmt"><a href="https://enzyme.expasy.org">ENZYME</a></h4> <nav class="header-elmt with-title" itemscope itemtype="http://www.schema.org/SiteNavigationElement"> <ul class="menu-6-items"> <li> <img src="/images/icons/home.svg" alt="home"> <a itemprop="url" href="/index.html"><span itemprop="name">Home</span></a> </li> <li class="with-submenu"> <img src="/images/icons/tool.svg" alt="tool"> <a itemprop="url" href="/cgi-bin/enzyme/enzyme-search-cl?1"><span itemprop="name">Browse</span></a> <ul> <li><a itemprop="url" href="/cgi-bin/enzyme/enzyme-search-cl?1"><span itemprop="name">by classes</span></a></li> <li><a itemprop="url" href="/cgi-bin/enzyme/enzyme-search-cl?2"><span itemprop="name">by subclasses</span></a></li> <li><a itemprop="url" href="/cgi-bin/enzyme/enzyme-search-cl?3"><span itemprop="name">by subsubclasses</span></a></li> </ul> </li> <li class="with-submenu"> <img src="/images/icons/browse.svg" alt="browse"> <a itemprop="url" href="/enzyme-search-ec.html"><span itemprop="name">Search</span></a> <ul> <li><a itemprop="url" href="/enzyme-search-ec.html"><span itemprop="name">by EC number</span></a></li> <li><a itemprop="url" href="/enzyme-byname.html"><span itemprop="name">by name</span></a></li> <li><a itemprop="url" href="/enzyme-bycompound.html"><span itemprop="name">by chemical compound</span></a></li> <li><a itemprop="url" href="/enzyme-bycomment.html"><span itemprop="name">by comment</span></a></li> </ul> </li> <li class="with-submenu"> <img src="/images/icons/documents.svg" alt="documents"> <a itemprop="url" href="https://ftp.expasy.org/databases/enzyme/"><span itemprop="name">Documentation</span></a> <ul> <li><a itemprop="url" href="https://ftp.expasy.org/databases/enzyme/enzuser.txt"><span itemprop="name">User Manual</span></a></li> <li><a itemprop="url" href="https://ftp.expasy.org/databases/enzyme/enzyme.get"><span itemprop="name">How to obtain ENZYME</span></a></li> </ul> </li> <li> <img src="/images/icons/download.svg" alt="download"> <a itemprop="url" href="https://ftp.expasy.org/databases/enzyme/"><span itemprop="name">Downloads</span></a> </li> <li> <img src="/images/icons/contact.svg" alt="contact"> <a itemprop="url" href="/contact"><span itemprop="name">Contact</span></a> </li> </ul> </nav> </header>  <main class="main-grid">  <h1 class="main-elmt">ENZYME entry: EC <span property="schema:alternateName">2.7.1.171</span></h1><div class="main-elmt" style="justify-self:center;"> <table class="type-1"> <tr><th colspan="2">Accepted Name</th></tr> <tr><td colspan="2"><strong property="schema:name">protein-fructosamine 3-kinase </strong></td></tr> <tr><th colspan="2">Alternative Name(s)</th></tr> <tr><td colspan="2"><strong property="schema:alternateName">fructosamine 3-kinase</strong></td></tr> <tr><th colspan="2">Reaction catalysed</th></tr> <tr><td colspan="2">N(6)-(D-fructosyl)-L-lysyl-[protein]<span class="color_d2"> + </span>ATP<span class="color_d2"> = </span>N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein]<span class="color_d2"> + </span>ADP<span class="color_d2"> + </span>H(+)</td></tr> <tr><th colspan="2">Comment(s)</th></tr> <tr><td colspan="2"><ul class="cc"><li>Nonenzymatic glycation is an important factor in the pathogenesis of diabetic complications. </li><li>Key early intermediates in this process are fructosamines, such as [protein]-N(6)-D-fructosyl-L-lysine. </li><li>Fructosamine-3-kinase is part of an ATP-dependent system for removing carbohydrates from nonenzymatically glycated proteins. </li><li>The phosphorylation destablilizes the [protein]-N(6)-D-fructosyl-L- lysine adduct and leads to its spontaneous decomposition. cf. EC <a href="/EC/2.7.1.172">2.7.1.172</a>. </li></ul></td></tr> <tr><th colspan="2">Cross-references</th></tr> <tr><td>BRENDA</td><td><a href="http://www.brenda-enzymes.org/enzyme.php?ecno=2.7.1.171">2.7.1.171</a></td></tr> <tr><td>EC2PDB</td><td><a href="https://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/enzymes/GetPage.pl?ec_number=2.7.1.171">2.7.1.171</a></td></tr> <tr><td>ExplorEnz</td><td><a href="http://www.enzyme-database.org/query.php?ec=2.7.1.171">2.7.1.171</a></td></tr> <tr><td>PRIAM enzyme-specific profiles</td><td><a href="http://priam.prabi.fr/cgi-bin/PRIAM_profiles_CurrentRelease.pl?EC=2.7.1.171">2.7.1.171</a></td></tr> <tr><td>KEGG Ligand Database for Enzyme Nomenclature</td><td><a href="http://www.genome.ad.jp/dbget-bin/www_bget?ec:2.7.1.171">2.7.1.171</a></td></tr> <tr><td>IUBMB Enzyme Nomenclature</td><td><a href="https://www.qmul.ac.uk/sbcs/iubmb/enzyme/EC2/7/1/171.html">2.7.1.171</a></td></tr> <tr><td>IntEnz</td><td><a href="https://www.ebi.ac.uk/intenz/query?cmd=SearchEC&ec=2.7.1.171">2.7.1.171</a></td></tr> <tr><td>MEDLINE</td><td><a href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=PureSearch&db=PubMed&details_term=2.7.1.171[EC/RN%20Number]">Find literature relating to 2.7.1.171</a></td></tr> <tr><td>MetaCyc</td><td><a href="https://biocyc.org/META/NEW-IMAGE?type=EC-NUMBER&object=EC-2.7.1.171">2.7.1.171</a></td></tr> <tr><td>Rhea expert-curated reactions</td><td><a href="https://www.rhea-db.org/rhea?query=ec%3A2.7.1.171">2.7.1.171</a></td></tr> <tr><td>UniProtKB/Swiss-Prot</td><td><table> <tr><td><a href="https://www.uniprot.org/uniprot/Q9H479">Q9H479</a>, FN3K_HUMAN</td><td><a href="https://www.uniprot.org/uniprot/Q9ER35">Q9ER35</a>, FN3K_MOUSE</td></table> </td></tr> </table> <br><a property="schema:sameAs" href="/cgi-bin/enzyme/get-enzyme-entry?2.7.1.171">View entry in original ENZYME format</a> <br><a property="schema:sameAs" href="/EC/2.7.1.171.txt">View entry in raw text format (no links)</a><br> <div property="schema:about" typeof="schema:DataSet"><a property="schema:url" href="https://www.uniprot.org/uniprotkb?query=(ec:2.7.1.171)%20AND%20(reviewed:true)">All UniProtKB/Swiss-Prot entries referenced in this entry</a>, with possibility to download in different formats, align etc. </div> All <a href="/EC/2.7.1.-">ENZYME</a> / <a href="https://www.uniprot.org/uniprotkb?query=(ec:2.7.1.-)%20AND%20(reviewed:true)">UniProtKB/Swiss-Prot</a> entries corresponding to 2.7.1.-<br> </span><span property="itemListElement" typeof="ListItem">All <a href="/EC/2.7.-.-">ENZYME</a> / <a href="https://www.uniprot.org/uniprotkb?query=(ec:2.7.-.-)%20AND%20(reviewed:true)">UniProtKB/Swiss-Prot</a> entries corresponding to 2.7.-.-<br> All <a href="/EC/2.-.-.-">ENZYME</a> / <a href="https://www.uniprot.org/uniprotkb?query=(ec:2.-.-.-)%20AND%20(reviewed:true)">UniProtKB/Swiss-Prot</a> entries corresponding to 2.-.-.-<br> </div> </div> </main>  <footer class="footer-grid"> <div class="footer-elmt"> <img alt="SIB logo" src="/images/sib_images/sib-mark.svg"> </div> <div class="footer-elmt" property="schema:creator" typeof="schema:NGO"> <a href="https://www.expasy.org" target="_blank">Expasy</a> is operated by the <a property="schema:url" href="https://sib.swiss" target="_blank">SIB Swiss Institute of Bioinformatics</a> <br> <a href="https://www.expasy.org/terms-of-use" target="_blank">Terms of Use</a> | <a href="https://www.sib.swiss/privacy-policy" target="_blank">Privacy policy</a> </div> <div class="footer-elmt"> <a href="#top">Back to the top</a> </div> </footer>  <script> var _paq = window._paq = window._paq || []; _paq.push( ['trackPageView'] ); _paq.push( ['enableLinkTracking'] ); ( function() { _paq.push(['setTrackerUrl', 'https://matomo.sib.swiss/matomo.php']); _paq.push(['setSiteId', '61']); } )(); </script> <script async="async" src="https://matomo.sib.swiss/matomo.js"></script>  </body> </html>

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ENZYME - 2.7.1.171 protein-fructosamine 3-kinase