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2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 551</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: benign prostatic lesions</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">371</span> Genotypic Identification of Oral Bacteria Using 16S rRNA in Children with and without Early Childhood Caries in Kelantan, Malaysia</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Zuliani%20Mahmood">Zuliani Mahmood</a>, <a href="https://publications.waset.org/abstracts/search?q=Thirumulu%20Ponnuraj%20Kannan"> Thirumulu Ponnuraj Kannan</a>, <a href="https://publications.waset.org/abstracts/search?q=Yean%20Yean%20Chan"> Yean Yean Chan</a>, <a href="https://publications.waset.org/abstracts/search?q=Salahddin%20A.%20Al-Hudhairy"> Salahddin A. Al-Hudhairy</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Caries is the most common childhood disease which develops due to disturbances in the physiological equilibrium in the dental plaque resulting in demineralization of tooth structures. Plaque and dentine samples were collected from three different tooth surfaces representing caries progression (intact, over carious lesion and dentine) in children with early childhood caries (ECC, n=36). In caries free (CF) children, plaque samples were collected from sound tooth surfaces at baseline and after one year (n=12). The genomic DNA was extracted from all samples and subjected to 16S rRNA PCR amplification. The end products were cloned into pCR®2.1-TOPO® Vector. Five randomly selected positive clones collected from each surface were sent for sequencing. Identification of the bacterial clones was performed using BLAST against GenBank database. In the ECC group, the frequency of Lactobacillus sp. detected was significantly higher in the dentine surface (p = 0.031) than over the cavitated lesion. The highest frequency of bacteria detected in the intact surfaces was Fusobacterium nucleatum subsp. polymorphum (33.3%) while Streptococcus mutans was detected over the carious lesions and dentine surfaces at a frequency of 33.3% and 52.7% respectively. Fusobacterium nucleatum subsp. polymorphum was also found to be highest in the CF group (41.6%). Follow up at the end of one year showed that the frequency of Corynebacterium matruchotii detected was highest in those who remained caries free (16.6%), while Porphyromonas catoniae was highest in those who developed caries (25%). In conclusion, Streptococcus mutans and Porphyromonas catoniae are strongly associated with caries progression, while Lactobacillus sp. is restricted to deep carious lesions. Fusobacterium nucleatum subsp. polymorphum and Corynebacterium matruchotii may play a role in sustaining the healthy equilibrium in the dental plaque. These identified bacteria show promise as potential biomarkers in diagnosis which could help in the management of dental caries in children. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=early%20childhood%20caries" title="early childhood caries">early childhood caries</a>, <a href="https://publications.waset.org/abstracts/search?q=genotypic%20identification" title=" genotypic identification"> genotypic identification</a>, <a href="https://publications.waset.org/abstracts/search?q=oral%20bacteria" title=" oral bacteria"> oral bacteria</a>, <a href="https://publications.waset.org/abstracts/search?q=16S%20rRNA" title=" 16S rRNA"> 16S rRNA</a> </p> <a href="https://publications.waset.org/abstracts/51882/genotypic-identification-of-oral-bacteria-using-16s-rrna-in-children-with-and-without-early-childhood-caries-in-kelantan-malaysia" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/51882.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">280</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">370</span> Imaging Spectrum of Central Nervous System Tuberculosis on Magnetic Resonance Imaging: Correlation with Clinical and Microbiological Results</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Vasundhara%20Arora">Vasundhara Arora</a>, <a href="https://publications.waset.org/abstracts/search?q=Anupam%20Jhobta"> Anupam Jhobta</a>, <a href="https://publications.waset.org/abstracts/search?q=Suresh%20Thakur"> Suresh Thakur</a>, <a href="https://publications.waset.org/abstracts/search?q=Sanjiv%20Sharma"> Sanjiv Sharma</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Aims and Objectives: Intracranial tuberculosis (TB) is one of the most devastating manifestations of TB and a challenging public health issue of considerable importance and magnitude world over. This study elaborates on the imaging spectrum of neurotuberculosis on magnetic resonance imaging (MRI) in 29 clinically suspected cases from a tertiary care hospital. Materials and Methods: The prospective hospital based evaluation of MR imaging features of neuro-tuberculosis in 29 clinically suspected cases was carried out in Department of Radio-diagnosis, Indira Gandhi Medical Hospital from July 2017 to August 2018. MR Images were obtained on a 1.5 T Magnetom Avanto machine and were analyzed to identify any abnormal meningeal enhancement or parenchymal lesions. Microbiological and Biochemical CSF analysis was performed in radio-logically suspected cases and the results were compared with the imaging data. Clinical follow up of the patients started on anti-tuberculous treatment was done to evaluate the response to treatment and clinical outcome. Results: Age range of patients in the study was between 1 year to 73 years. The mean age of presentation was 11.5 years. No significant difference in the distribution of cerebral tuberculosis was noted among the two genders. Imaging findings of neuro-tuberculosis obtained were varied and non specific ranging from lepto-meningeal enhancement, cerebritis to space occupying lesions such as tuberculomas and tubercular abscesses. Complications presenting as hydrocephalus (n= 7) and infarcts (n=9) was noted in few of these patients. 29 patients showed radiological suspicion of CNS tuberculosis with meningitis alone observed in 11 cases, tuberculomas alone were observed in 4 cases, meningitis with parenchymal tuberculomas in 11 cases. Tubercular abscess and cerebritis were observed in one case each. Tuberculous arachnoiditis was noted in one patient. Gene expert positivity was obtained in 11 out of 29 radiologically suspected patients; none of the patients showed culture positivity. Meningeal form of the disease alone showed higher positivity rate of gene Xpert (n=5) followed by combination of meningeal and parenchymal forms of disease (n=4). The parenchymal manifestation of disease alone showed least positivity rates (n= 3) with gene xpert testing. All 29 patients were started on anti tubercular treatment based on radiological suspicion of the disease with clinical improvement observed in 27 treated patients. Conclusions: In our study, higher incidence of neuro- tuberculosis was noted in paediatric population with predominance of the meningeal form of the disease. Gene Xpert positivity obtained was low due to paucibacillary nature of cerebrospinal fluid (CSF) with even lower positivity of CSF samples in parenchymal form of the manifestation. MRI showed high accuracy in detecting CNS lesions in neuro-tuberculosis. Hence, it can be concluded that MRI plays a crucial role in the diagnosis because of its inherent sensitivity and specificity and is an indispensible imaging modality. It caters to the need of early diagnosis owing to poor sensitivity of microbiological tests more so in the parenchymal manifestation of the disease. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=neurotuberculosis" title="neurotuberculosis">neurotuberculosis</a>, <a href="https://publications.waset.org/abstracts/search?q=tubercular%20abscess" title=" tubercular abscess"> tubercular abscess</a>, <a href="https://publications.waset.org/abstracts/search?q=tuberculoma" title=" tuberculoma"> tuberculoma</a>, <a href="https://publications.waset.org/abstracts/search?q=tuberculous%20meningitis" title=" tuberculous meningitis"> tuberculous meningitis</a> </p> <a href="https://publications.waset.org/abstracts/101606/imaging-spectrum-of-central-nervous-system-tuberculosis-on-magnetic-resonance-imaging-correlation-with-clinical-and-microbiological-results" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/101606.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">176</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">369</span> Ischemic Stroke Detection in Computed Tomography Examinations</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Allan%20F.%20F.%20Alves">Allan F. F. Alves</a>, <a href="https://publications.waset.org/abstracts/search?q=Fernando%20A.%20Bacchim%20Neto"> Fernando A. Bacchim Neto</a>, <a href="https://publications.waset.org/abstracts/search?q=Guilherme%20Giacomini"> Guilherme Giacomini</a>, <a href="https://publications.waset.org/abstracts/search?q=Marcela%20de%20Oliveira"> Marcela de Oliveira</a>, <a href="https://publications.waset.org/abstracts/search?q=Ana%20L.%20M.%20Pavan"> Ana L. M. Pavan</a>, <a href="https://publications.waset.org/abstracts/search?q=Maria%20E.%20D.%20Rosa"> Maria E. D. Rosa</a>, <a href="https://publications.waset.org/abstracts/search?q=Diana%20R.%20Pina"> Diana R. Pina</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Stroke is a worldwide concern, only in Brazil it accounts for 10% of all registered deaths. There are 2 stroke types, ischemic (87%) and hemorrhagic (13%). Early diagnosis is essential to avoid irreversible cerebral damage. Non-enhanced computed tomography (NECT) is one of the main diagnostic techniques used due to its wide availability and rapid diagnosis. Detection depends on the size and severity of lesions and the time spent between the first symptoms and examination. The Alberta Stroke Program Early CT Score (ASPECTS) is a subjective method that increases the detection rate. The aim of this work was to implement an image segmentation system to enhance ischemic stroke and to quantify the area of ischemic and hemorrhagic stroke lesions in CT scans. We evaluated 10 patients with NECT examinations diagnosed with ischemic stroke. Analyzes were performed in two axial slices, one at the level of the thalamus and basal ganglion and one adjacent to the top edge of the ganglionic structures with window width between 80 and 100 Hounsfield Units. We used different image processing techniques such as morphological filters, discrete wavelet transform and Fuzzy C-means clustering. Subjective analyzes were performed by a neuroradiologist according to the ASPECTS scale to quantify ischemic areas in the middle cerebral artery region. These subjective analysis results were compared with objective analyzes performed by the computational algorithm. Preliminary results indicate that the morphological filters actually improve the ischemic areas for subjective evaluations. The comparison in area of the ischemic region contoured by the neuroradiologist and the defined area by computational algorithm showed no deviations greater than 12% in any of the 10 examination tests. Although there is a tendency that the areas contoured by the neuroradiologist are smaller than those obtained by the algorithm. These results show the importance of a computer aided diagnosis software to assist neuroradiology decisions, especially in critical situations as the choice of treatment for ischemic stroke. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=ischemic%20stroke" title="ischemic stroke">ischemic stroke</a>, <a href="https://publications.waset.org/abstracts/search?q=image%20processing" title=" image processing"> image processing</a>, <a href="https://publications.waset.org/abstracts/search?q=CT%20scans" title=" CT scans"> CT scans</a>, <a href="https://publications.waset.org/abstracts/search?q=Fuzzy%20C-means" title=" Fuzzy C-means "> Fuzzy C-means </a> </p> <a href="https://publications.waset.org/abstracts/39714/ischemic-stroke-detection-in-computed-tomography-examinations" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/39714.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">374</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">368</span> A Convolutional Deep Neural Network Approach for Skin Cancer Detection Using Skin Lesion Images</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Firas%20Gerges">Firas Gerges</a>, <a href="https://publications.waset.org/abstracts/search?q=Frank%20Y.%20Shih"> Frank Y. Shih</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Malignant melanoma, known simply as melanoma, is a type of skin cancer that appears as a mole on the skin. It is critical to detect this cancer at an early stage because it can spread across the body and may lead to the patient's death. When detected early, melanoma is curable. In this paper, we propose a deep learning model (convolutional neural networks) in order to automatically classify skin lesion images as malignant or benign. Images underwent certain pre-processing steps to diminish the effect of the normal skin region on the model. The result of the proposed model showed a significant improvement over previous work, achieving an accuracy of 97%. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=deep%20learning" title="deep learning">deep learning</a>, <a href="https://publications.waset.org/abstracts/search?q=skin%20cancer" title=" skin cancer"> skin cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=image%20processing" title=" image processing"> image processing</a>, <a href="https://publications.waset.org/abstracts/search?q=melanoma" title=" melanoma"> melanoma</a> </p> <a href="https://publications.waset.org/abstracts/134720/a-convolutional-deep-neural-network-approach-for-skin-cancer-detection-using-skin-lesion-images" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/134720.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">156</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">367</span> Comparison of Monte Carlo Simulations and Experimental Results for the Measurement of Complex DNA Damage Induced by Ionizing Radiations of Different Quality</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ifigeneia%20V.%20Mavragani">Ifigeneia V. Mavragani</a>, <a href="https://publications.waset.org/abstracts/search?q=Zacharenia%20Nikitaki"> Zacharenia Nikitaki</a>, <a href="https://publications.waset.org/abstracts/search?q=George%20Kalantzis"> George Kalantzis</a>, <a href="https://publications.waset.org/abstracts/search?q=George%20Iliakis"> George Iliakis</a>, <a href="https://publications.waset.org/abstracts/search?q=Alexandros%20G.%20Georgakilas"> Alexandros G. Georgakilas</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Complex DNA damage consisting of a combination of DNA lesions, such as Double Strand Breaks (DSBs) and non-DSB base lesions occurring in a small volume is considered as one of the most important biological endpoints regarding ionizing radiation (IR) exposure. Strong theoretical (Monte Carlo simulations) and experimental evidence suggests an increment of the complexity of DNA damage and therefore repair resistance with increasing linear energy transfer (LET). Experimental detection of complex (clustered) DNA damage is often associated with technical deficiencies limiting its measurement, especially in cellular or tissue systems. Our groups have recently made significant improvements towards the identification of key parameters relating to the efficient detection of complex DSBs and non-DSBs in human cellular systems exposed to IR of varying quality (γ-, X-rays 0.3-1 keV/μm, α-particles 116 keV/μm and 36Ar ions 270 keV/μm). The induction and processing of DSB and non-DSB-oxidative clusters were measured using adaptations of immunofluorescence (γH2AX or 53PB1 foci staining as DSB probes and human repair enzymes OGG1 or APE1 as probes for oxidized purines and abasic sites respectively). In the current study, Relative Biological Effectiveness (RBE) values for DSB and non-DSB induction have been measured in different human normal (FEP18-11-T1) and cancerous cell lines (MCF7, HepG2, A549, MO59K/J). The experimental results are compared to simulation data obtained using a validated microdosimetric fast Monte Carlo DNA Damage Simulation code (MCDS). Moreover, this simulation approach is implemented in two realistic clinical cases, i.e. prostate cancer treatment using X-rays generated by a linear accelerator and a pediatric osteosarcoma case using a 200.6 MeV proton pencil beam. RBE values for complex DNA damage induction are calculated for the tumor areas. These results reveal a disparity between theory and experiment and underline the necessity for implementing highly precise and more efficient experimental and simulation approaches. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=complex%20DNA%20damage" title="complex DNA damage">complex DNA damage</a>, <a href="https://publications.waset.org/abstracts/search?q=DNA%20damage%20simulation" title=" DNA damage simulation"> DNA damage simulation</a>, <a href="https://publications.waset.org/abstracts/search?q=protons" title=" protons"> protons</a>, <a href="https://publications.waset.org/abstracts/search?q=radiotherapy" title=" radiotherapy"> radiotherapy</a> </p> <a href="https://publications.waset.org/abstracts/60953/comparison-of-monte-carlo-simulations-and-experimental-results-for-the-measurement-of-complex-dna-damage-induced-by-ionizing-radiations-of-different-quality" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/60953.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">331</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">366</span> An Eco-Friendly Preparations of Izonicotinamide Quaternary Salts in Deep Eutectic Solvents </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Dajana%20Ga%C5%A1o-Soka%C4%8D">Dajana Gašo-Sokač</a>, <a href="https://publications.waset.org/abstracts/search?q=Valentina%20Bu%C5%A1i%C4%87"> Valentina Bušić</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Deep eutectic solvents (DES) are liquids composed of two or three safe, inexpensive components, often interconnected by noncovalent hydrogen bonds which produce eutectic mixture whose melting point is lower than that of each component. No data in literature have been found on the quaternization reaction in DES. The use of DES have several advantages: they are environmentally benign and biodegradable, easy for purification and simple for preparation. An environmentally sustainable method for preparing quaternary salts of izonicotinamide and substituted 2-bromoacetophenones was demonstrated here using choline chloride-based DES. The quaternization reaction was carried out by three synthetic approaches: conventional method, microwave and ultrasonic irradiation. We showed that the highest yields were obtained by the microwave method. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=deep%20eutectic%20solvents" title="deep eutectic solvents">deep eutectic solvents</a>, <a href="https://publications.waset.org/abstracts/search?q=izonicotinamide%20salts" title=" izonicotinamide salts"> izonicotinamide salts</a>, <a href="https://publications.waset.org/abstracts/search?q=microwave%20synthesis" title=" microwave synthesis"> microwave synthesis</a>, <a href="https://publications.waset.org/abstracts/search?q=ultrasonic%20irradiation" title=" ultrasonic irradiation"> ultrasonic irradiation</a> </p> <a href="https://publications.waset.org/abstracts/118856/an-eco-friendly-preparations-of-izonicotinamide-quaternary-salts-in-deep-eutectic-solvents" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/118856.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">135</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">365</span> Imaging Features of Hepatobiliary Histiocytosis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ayda%20Youssef">Ayda Youssef</a>, <a href="https://publications.waset.org/abstracts/search?q=Tarek%20Rafaat"> Tarek Rafaat</a>, <a href="https://publications.waset.org/abstracts/search?q=Iman%20zaky"> Iman zaky</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Purpose: Langerhans’ cell histiocytosis (LCH) is not uncommon pathology that implies aberrant proliferation of a specific dendritic (Langerhans) cell. These atypical but mature cells of monoclonal origin can infiltrate many sites of the body and may occur as localized lesions or as widespread systemic disease. Liver is one of the uncommon sites of affection. The twofold objective of this study is to illustrate the radiological presentation of this disease, and to compare these results with previously reported series. Methods and Materials: Between 2007 and 2012, 150 patients with biopsy-proven LCH were treated in our hospital, a paediatric cancer tertiary care center. A retrospective review of radiographic images and reports was performed. There were 33 patients with liver affection are stratified. All patients underwent imaging studies, mostly US and CT. A chart review was performed to obtain demographic, clinical and radiological data. They were analyzed and compared to other published series. Results: Retrospective assessment of 150 patients with LCH was performed, among them 33 patients were identified who had liver involvement. All these patients developed multisystemic disease; They were 12 females and 21 males with (n= 32), seven of them had marked hepatomegaly. Diffuse hypodense liver parenchyma was encountered in five cases, the periportal location has a certain predilection in cases of focal affection where three cases has a hypodense periportal soft tissue sheets, one of them associated with dilated biliary radicals, only one case has multiple focal lesions unrelated to portal tracts. On follow up of the patients, two cases show abnormal morphology of liver with bossy outline. Conclusion: LCH is a not infrequent disease. A high-index suspicion should be raised in the context of diagnosis of liver affection. A biopsy is recommended in the presence of radiological suspicion. Chemotherapy is the preferred therapeutic modality. Liver histiocytosis are not disease specific features but should be interpreted in conjunction with the clinical history and the results of biopsy. Clinical Relevance/Application: Radiologist should be aware of different patterns of hepatobiliary histiocytosis, Thus early diagnosis and proper management of patient can be conducted. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=langerhans%E2%80%99%20cell%20histiocytosis" title="langerhans’ cell histiocytosis">langerhans’ cell histiocytosis</a>, <a href="https://publications.waset.org/abstracts/search?q=liver" title=" liver"> liver</a>, <a href="https://publications.waset.org/abstracts/search?q=medical%20and%20health%20sciences" title=" medical and health sciences"> medical and health sciences</a>, <a href="https://publications.waset.org/abstracts/search?q=radiology" title=" radiology"> radiology</a> </p> <a href="https://publications.waset.org/abstracts/22957/imaging-features-of-hepatobiliary-histiocytosis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/22957.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">285</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">364</span> Effects of Visual Agnosia in Children’s Linguistic Abilities: Psychoneurolinguistic Approach</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sadeq%20Al%20Yaari">Sadeq Al Yaari</a>, <a href="https://publications.waset.org/abstracts/search?q=Ayman%20Al%20Yaari"> Ayman Al Yaari</a>, <a href="https://publications.waset.org/abstracts/search?q=Adham%20Al%20Yaari"> Adham Al Yaari</a>, <a href="https://publications.waset.org/abstracts/search?q=Montaha%20Al%20Yaari"> Montaha Al Yaari</a>, <a href="https://publications.waset.org/abstracts/search?q=Aayah%20Al%20Yaari"> Aayah Al Yaari</a>, <a href="https://publications.waset.org/abstracts/search?q=Sajedah%20Al%20Yaari"> Sajedah Al Yaari</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Objective: The aim of the study is to examine the relationship between visual agnosia and learning delay in Yemeni children. Method: A total of 80 subjects (experimental group= 60, 30 males and 30 females and control group= 20, 10 males and 10 females) in two institutions (old and new). The age of all subjects at hand ranges between 6- and 12 years old. Pre and post-tests were administered. Results: Outline results show severe effects on the performance of the children due to visual agnosia this effect was benign in the group that received the treatment, and this can be clearly seen in their results in the post-test compared to the other group that did not receive the treatment and outcomes in general can be better understood in light of the control group. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=visual" title="visual">visual</a>, <a href="https://publications.waset.org/abstracts/search?q=agnosia" title=" agnosia"> agnosia</a>, <a href="https://publications.waset.org/abstracts/search?q=linguistics" title=" linguistics"> linguistics</a>, <a href="https://publications.waset.org/abstracts/search?q=abilities" title=" abilities"> abilities</a>, <a href="https://publications.waset.org/abstracts/search?q=effects" title=" effects"> effects</a>, <a href="https://publications.waset.org/abstracts/search?q=psychoneurolinguistics" title=" psychoneurolinguistics"> psychoneurolinguistics</a> </p> <a href="https://publications.waset.org/abstracts/187000/effects-of-visual-agnosia-in-childrens-linguistic-abilities-psychoneurolinguistic-approach" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/187000.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">51</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">363</span> The Effect of Vitamin D Supplementation on Prostate Cancer: A Systematic Review and Meta-Analysis of Clinical Trials</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Simin%20Shahvazi">Simin Shahvazi</a>, <a href="https://publications.waset.org/abstracts/search?q=Sepideh%20Soltani"> Sepideh Soltani</a>, <a href="https://publications.waset.org/abstracts/search?q=Seyed%20Mehdi%20Ahmadi"> Seyed Mehdi Ahmadi</a>, <a href="https://publications.waset.org/abstracts/search?q=Russell%20J.%20De%20Souza"> Russell J. De Souza</a>, <a href="https://publications.waset.org/abstracts/search?q=Amin%20Salehi-Abargouei"> Amin Salehi-Abargouei</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background and Objectives: Vitamin D has received attention for its potential to disrupt cancer processes such as attenuating cell proliferation and exacerbating differentiation and apoptosis. However, whether there exists a role for vitamin D in the treatment of prostate cancer specifically remains controversial. We systematically review the literature to assess whether supplementation with vitamin D influences PSA response and overall survival in patients with prostate cancer. Methods: We searched PubMed, Scopus, ISI Web of Science and Google scholar from inception through up to 10 September 2017 for both before-and-after and randomized trials that evaluated the effect of vitamin D supplementation on the prostate specific antigen (PSA) response rate in participants with prostate cancer. The DerSimonian and Laird, inverse-weighted random-effects model was used to pool effect estimates from the studies. Heterogeneity and potential publication bias were evaluated. Subgroup analyses were also performed. Results: Twenty-two studies (16 before-after and 6 randomized controlled trials) were found and included in meta-analysis. The analysis on controlled clinical trials revealed that PSA change from baseline [weighted mean difference (WMD) = -1.66 ng/ml, 95%CI: -0.69, 0.36, P= 0.543)], PSA response (RR=1.18, 95%CI: 0.97, 1.45, P=0.104) and mortality rate (risk ratio (RR) = 1.05, 95% CI: 0.81-1.36; P=0.713) was not significantly different between vitamin D supplementation and placebo groups. Single arm trials revealed that vitamin D supplementation had had a modest effect on PSA response rate: 19% of those enrolled had at least a 50% reduction in PSA by the end of treatment (95% CI: 7% to 31%; p=0.002). Conclusion: We found that vitamin D modestly increases the PSA response rate in single arm studies. No effect on serum PSA levels, PSA response and mortality was seen in randomized controlled clinical trials. It does not seem patients with prostate cancer benefit from vitamin D supplementation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=mortality" title="mortality">mortality</a>, <a href="https://publications.waset.org/abstracts/search?q=prostatic%20neoplasms" title=" prostatic neoplasms"> prostatic neoplasms</a>, <a href="https://publications.waset.org/abstracts/search?q=PSA%20response" title=" PSA response"> PSA response</a>, <a href="https://publications.waset.org/abstracts/search?q=vitamin%20D" title=" vitamin D"> vitamin D</a> </p> <a href="https://publications.waset.org/abstracts/100491/the-effect-of-vitamin-d-supplementation-on-prostate-cancer-a-systematic-review-and-meta-analysis-of-clinical-trials" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/100491.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">199</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">362</span> Treatment of Premalignant Lesions: Curcumin a Promising Non-Surgical Option </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Heba%20A.%20Hazzah">Heba A. Hazzah</a>, <a href="https://publications.waset.org/abstracts/search?q=Ragwa%20M.%20Farid"> Ragwa M. Farid</a>, <a href="https://publications.waset.org/abstracts/search?q=Maha%20M.%20A.%20Nasra"> Maha M. A. Nasra</a>, <a href="https://publications.waset.org/abstracts/search?q=Mennatallah%20Zakria"> Mennatallah Zakria</a>, <a href="https://publications.waset.org/abstracts/search?q=Magda%20A.%20El%20Massik"> Magda A. El Massik</a>, <a href="https://publications.waset.org/abstracts/search?q=Ossama%20Y.%20Abdallah"> Ossama Y. Abdallah</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: Curcumin (Cur) is a polyphenol derived from the herbal remedy and dietary spice turmeric. It possesses diverse anti-inflammatory and anti-cancer properties following oral or topical administration. The buccal delivery of curcumin can be useful for both systemic and local disease treatments such as gingivitis, periodontal diseases, oral carcinomas, and precancerous oral lesions. Despite of its high activity, it suffers a limited application due to its low oral bioavailability, poor aqueous solubility, and instability. Aim: Preparation and characterization of curcumin solid lipid nanoparticles with a high loading capacity into a mucoadhesive gel for buccal application. Methodology: Curcumin was formulated as nanoparticles using different lipids, namely Gelucire 39/01, Gelucire 50/13, Precirol, Compritol, and Polaxomer 407 as a surfactant. The SLN were dispersed in a mucoadhesive gel matrix to be applied to the buccal mucosa. All formulations were evaluated for their content, entrapment efficiency, particle size, in vitro drug dialysis, ex vivo mucoadhesion test, and ex vivo permeation study using chicken buccal mucosa. Clinical evaluation was conducted on 15 cases suffering oral erythroplakia and erosive lichen planus. Results: The results showed high entrapment efficiency reaching almost 90 % using Gelucire 50, the loaded gel with Cur-SLN showed good adhesion property and 25 minutes in vivo residence time. In addition to stability enhancement for the Cur powder. All formulae did not show any drug permeated however, a significant amount of Cur was retained within the mucosal tissue. Pain and lesion sizes were significantly reduced upon topical treatment. Complete healing was observed after 6 weeks of treatment. Conclusion: These results open a room for the pharmaceutical technology to optimize the use of this golden magical powder to get the best out of it. In addition, the lack of local anti-inflammatory compounds with reduced side effects intensifies the importance of studying natural products for this purpose. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=curcumin" title="curcumin">curcumin</a>, <a href="https://publications.waset.org/abstracts/search?q=erythroplakia" title=" erythroplakia"> erythroplakia</a>, <a href="https://publications.waset.org/abstracts/search?q=mucoadhesive" title=" mucoadhesive"> mucoadhesive</a>, <a href="https://publications.waset.org/abstracts/search?q=pain" title=" pain"> pain</a>, <a href="https://publications.waset.org/abstracts/search?q=solid%20lipid%20nanoparticles" title=" solid lipid nanoparticles"> solid lipid nanoparticles</a> </p> <a href="https://publications.waset.org/abstracts/30690/treatment-of-premalignant-lesions-curcumin-a-promising-non-surgical-option" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/30690.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">453</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">361</span> A Green Analytical Curriculum for Renewable STEM Education</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mian%20Jiang">Mian Jiang</a>, <a href="https://publications.waset.org/abstracts/search?q=Zhenyi%20Wu"> Zhenyi Wu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> We have incorporated green components into existing analytical chemistry curriculum with the aims to present a more environment benign approach in both teaching laboratory and undergraduate research. These include the use of cheap, sustainable, and market-available material; minimized waste disposal, replacement of non-aqueous media; and scale-down in sample/reagent consumption. Model incorporations have covered topics in quantitative chemistry as well as instrumental analysis, lower division as well as upper level, and research in traditional titration, spectroscopy, electrochemical analysis, and chromatography. The green embedding has made chemistry more daily life relevance, and application focus. Our approach has the potential to expand into all STEM fields to make renewable, high-impact education experience for undergraduate students. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=green%20analytical%20chemistry" title="green analytical chemistry">green analytical chemistry</a>, <a href="https://publications.waset.org/abstracts/search?q=pencil%20lead" title=" pencil lead"> pencil lead</a>, <a href="https://publications.waset.org/abstracts/search?q=mercury" title=" mercury"> mercury</a>, <a href="https://publications.waset.org/abstracts/search?q=renewable" title=" renewable"> renewable</a> </p> <a href="https://publications.waset.org/abstracts/48969/a-green-analytical-curriculum-for-renewable-stem-education" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/48969.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">349</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">360</span> Rethinking the Value of Pancreatic Cyst CEA Levels from Endoscopic Ultrasound Fine-Needle Aspiration (EUS-FNA): A Longitudinal Analysis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Giselle%20Tran">Giselle Tran</a>, <a href="https://publications.waset.org/abstracts/search?q=Ralitza%20Parina"> Ralitza Parina</a>, <a href="https://publications.waset.org/abstracts/search?q=Phuong%20T.%20Nguyen"> Phuong T. Nguyen</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background/Aims: Pancreatic cysts (PC) have recently become an increasingly common entity, often diagnosed as incidental findings on cross-sectional imaging. Clinically, management of the lesions is difficult because of uncertainties in their potential for malignant degeneration. Prior series have reported that carcinoembryonic antigen (CEA), a biomarker collected from cyst fluid aspiration, has a high diagnostic accuracy for discriminating between mucinous and non-mucinous lesions, at the patient’s initial presentation. To the author’s best knowledge, no prior studies have reported PC CEA levels obtained from endoscopic ultrasound fine-needle aspiration (EUS-FNA) over years of serial EUS surveillance imaging. Methods: We report a consecutive retrospective series of 624 patients who underwent EUS evaluation for a PC between 11/20/2009 and 11/13/2018. Of these patients, 401 patients had CEA values obtained at the point of entry. Of these, 157 patients had two or more CEA values obtained over the course of their EUS surveillance. Of the 157 patients (96 F, 61 M; mean age 68 [range, 62-76]), the mean interval of EUS follow-up was 29.7 months [3.5-128]. The mean number of EUS procedures was 3 [2-7]. To assess CEA value fluctuations, we defined an appreciable increase in CEA as "spikes" – two-times increase in CEA on a subsequent EUS-FNA of the same cyst, with the second CEA value being greater than 1000 ng/mL. Using this definition, cysts with a spike in CEA were compared to those without a spike in a bivariate analysis to determine if a CEA spike is associated with poorer outcomes and the presence of high-risk features. Results: Of the 157 patients analyzed, 29 had a spike in CEA. Of these 29 patients, 5 had a cyst with size increase >0.5cm (p=0.93); 2 had a large cyst, >3cm (p=0.77); 1 had a cyst that developed a new solid component (p=0.03); 7 had a cyst with a solid component at any time during surveillance (p=0.08); 21 had a complex cyst (p=0.34); 4 had a cyst categorized as "Statistically Higher Risk" based on molecular analysis (p=0.11); and 0 underwent surgical resection (p=0.28). Conclusion: With serial EUS imaging in the surveillance of PC, an increase in CEA level defined as a spike did not predict poorer outcomes. Most notably, a spike in CEA did not correlate with the number of patients sent to surgery or patients with an appreciable increase in cyst size. A spike in CEA did not correlate with the development of a solid nodule within the PC nor progression on molecular analysis. Future studies should focus on the selected use of CEA analysis when patients undergo EUS surveillance evaluation for PCs. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=carcinoembryonic%20antigen%20%28CEA%29" title="carcinoembryonic antigen (CEA)">carcinoembryonic antigen (CEA)</a>, <a href="https://publications.waset.org/abstracts/search?q=endoscopic%20ultrasound%20%28EUS%29" title=" endoscopic ultrasound (EUS)"> endoscopic ultrasound (EUS)</a>, <a href="https://publications.waset.org/abstracts/search?q=fine-needle%20aspiration%20%28FNA%29" title=" fine-needle aspiration (FNA)"> fine-needle aspiration (FNA)</a>, <a href="https://publications.waset.org/abstracts/search?q=pancreatic%20cyst" title=" pancreatic cyst"> pancreatic cyst</a>, <a href="https://publications.waset.org/abstracts/search?q=spike" title=" spike"> spike</a> </p> <a href="https://publications.waset.org/abstracts/148012/rethinking-the-value-of-pancreatic-cyst-cea-levels-from-endoscopic-ultrasound-fine-needle-aspiration-eus-fna-a-longitudinal-analysis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/148012.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">147</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">359</span> Congenital Sublingual Dermoid Cyst with Cutaneous Fistula</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Rafael%20Ricieri">Rafael Ricieri</a>, <a href="https://publications.waset.org/abstracts/search?q=Rogerio%20Barros"> Rogerio Barros</a>, <a href="https://publications.waset.org/abstracts/search?q=Francisco%20Clovis"> Francisco Clovis</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Objective– The Objective of this is study is to report a rare case of dermoid cyst, with a sublingual location and cutaneous fistula in a 4 year-old child.Methods: This study is a case report. The main study instrument was the medical record and the radiological and intraoperative image bank. Results: Infants with congenital cervical lesions eventually need tomography for diagnostic elucidation, and health services should be structured to perform sedation and thin tomographic sections in order to reduce morbidity. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=congenital" title="congenital">congenital</a>, <a href="https://publications.waset.org/abstracts/search?q=sublingual%20dermoid%20cyst" title=" sublingual dermoid cyst"> sublingual dermoid cyst</a>, <a href="https://publications.waset.org/abstracts/search?q=fistula" title=" fistula"> fistula</a>, <a href="https://publications.waset.org/abstracts/search?q=pediatric%20surgery" title=" pediatric surgery"> pediatric surgery</a>, <a href="https://publications.waset.org/abstracts/search?q=head%20and%20kneck%20surgery" title=" head and kneck surgery"> head and kneck surgery</a> </p> <a href="https://publications.waset.org/abstracts/156843/congenital-sublingual-dermoid-cyst-with-cutaneous-fistula" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/156843.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">97</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">358</span> Septic Pulmonary Emboli as a Complication of Peripheral Venous Cannula Insertion</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ankita%20Baidya">Ankita Baidya</a>, <a href="https://publications.waset.org/abstracts/search?q=Vanishri%20Ganakumar"> Vanishri Ganakumar</a>, <a href="https://publications.waset.org/abstracts/search?q=Ranveer%20S.%20Jadon"> Ranveer S. Jadon</a>, <a href="https://publications.waset.org/abstracts/search?q=Piyush%20Ranjan"> Piyush Ranjan</a>, <a href="https://publications.waset.org/abstracts/search?q=Rita%20Sood"> Rita Sood</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Septic embolism can have varied presentations and clinical considerations. Infected central venous catheters are commonly associated with septic emboli but peripheral vascular catheters are rarely implicated. We describe a rare case of septic pulmonary emboli related to infected peripheral venous cannulation caused by an unusual etiological agent. A young male presented with complaints of fever, productive cough, sudden onset shortness of breath and cellulitis in both the upper limbs. He was recently hospitalised for dengue fever and administered intravenous fluids through peripheral venous line. The patient was febrile, tachypneic and in respiratory distress, there were multiple pus filled bullae in left hand alongwith swelling and erythema involving right forearm that started at the site of cannulation. Chest examination showed active accessory muscles of respiration, stony dull percussion at the base of right lung and decreased breath sounds at right infrascapular, infraaxillary and mammary area. Other system examination was within normal limits. Chest X-ray revealed bilateral multiple patchy heterogenous peripheral opacities and infiltrates with right-sided pleural effusion. Contrast-enhanced computed tomography (CECT) chest showed feeding vessel sign confirming the diagnosis as septic emboli. Venous Doppler and 2D-echocardiogarm were normal. Laboratory findings showed marked leucocytosis (22000/mm3). Pus aspirate, blood sample, and sputum sample were sent for microbiological testing. The patient was started empirically on ceftriaxone, vancomycin, and clindamycin. The Pus culture and sputum culture showed Klebsiella pneumoniae sensitive to cefoperazone-sulbactum, piperacillin-tazobactum, meropenem and amikacin. The antibiotics were modified accordingly to antimicrobial sensitivity profile to Cefoperazone-sulbactum. Bronchoalveolar lavage (BAL) was done and sent for microbiological investigations. BAL culture showed Klebsiella pneumoniae with same antimicrobial resistance profile. On day 6 of starting cefoperazone-sulbactum, he became afebrile. The skin lesions improved significantly. He was administered 2 weeks of cefoperazone–sulbactum and discharged on oral faropenem for 4 weeks. At the time of discharge, TLC was 11200/mm3 with marked radiological resolution of infection and healed skin lesions. He was kept in regular follow up. Chest X-ray and skin lesions showed complete resolution after 8 weeks. Till date, only couple of case reports of septic emboli through peripheral intravenous line have been reported in English literature. This case highlights that a simple procedure of peripheral intravenous cannulation can lead to catastrophic complication of septic pulmonary emboli and widespread cellulitis if not done with proper care and precautions. Also, the usual pathogens in such clinical settings are gram positive bacteria, but with the history of recent hospitalization, empirical therapy should also cover drug resistant gram negative microorganisms. It also emphasise the importance of appropriate healthcare practices to be taken care during all procedures. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antibiotics" title="antibiotics">antibiotics</a>, <a href="https://publications.waset.org/abstracts/search?q=cannula" title=" cannula"> cannula</a>, <a href="https://publications.waset.org/abstracts/search?q=Klebsiella%20pneumoniae" title=" Klebsiella pneumoniae"> Klebsiella pneumoniae</a>, <a href="https://publications.waset.org/abstracts/search?q=septic%20emboli" title=" septic emboli"> septic emboli</a> </p> <a href="https://publications.waset.org/abstracts/72649/septic-pulmonary-emboli-as-a-complication-of-peripheral-venous-cannula-insertion" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/72649.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">168</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">357</span> A Machine Learning Approach to Detecting Evasive PDF Malware</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Vareesha%20Masood">Vareesha Masood</a>, <a href="https://publications.waset.org/abstracts/search?q=Ammara%20Gul"> Ammara Gul</a>, <a href="https://publications.waset.org/abstracts/search?q=Nabeeha%20Areej"> Nabeeha Areej</a>, <a href="https://publications.waset.org/abstracts/search?q=Muhammad%20Asif%20Masood"> Muhammad Asif Masood</a>, <a href="https://publications.waset.org/abstracts/search?q=Hamna%20Imran"> Hamna Imran</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The universal use of PDF files has prompted hackers to use them for malicious intent by hiding malicious codes in their victim’s PDF machines. Machine learning has proven to be the most efficient in identifying benign files and detecting files with PDF malware. This paper has proposed an approach using a decision tree classifier with parameters. A modern, inclusive dataset CIC-Evasive-PDFMal2022, produced by Lockheed Martin’s Cyber Security wing is used. It is one of the most reliable datasets to use in this field. We designed a PDF malware detection system that achieved 99.2%. Comparing the suggested model to other cutting-edge models in the same study field, it has a great performance in detecting PDF malware. Accordingly, we provide the fastest, most reliable, and most efficient PDF Malware detection approach in this paper. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=PDF" title="PDF">PDF</a>, <a href="https://publications.waset.org/abstracts/search?q=PDF%20malware" title=" PDF malware"> PDF malware</a>, <a href="https://publications.waset.org/abstracts/search?q=decision%20tree%20classifier" title=" decision tree classifier"> decision tree classifier</a>, <a href="https://publications.waset.org/abstracts/search?q=random%20forest%20classifier" title=" random forest classifier"> random forest classifier</a> </p> <a href="https://publications.waset.org/abstracts/172206/a-machine-learning-approach-to-detecting-evasive-pdf-malware" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/172206.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">98</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">356</span> A Rare Case Report of Non-Langerhans Cell Cutaneous Histiocytosis in a 6-Month Old Infant</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Apoorva%20D.%20R.">Apoorva D. R.</a> </p> <p class="card-text"><strong>Abstract:</strong></p> INTRODUCTION: Hemophagocytic lymphohistiocytosis (HLH) is a severe, potentially fatal syndrome in which there is excessive immune activation. The disease is seen in children and people of all ages, but infants from birth to 18 months are most frequently affected. HLH is a sporadic or familial condition that can be triggered by various events that disturb immunological homeostasis. In cases with a genetic predisposition and sporadic occurrences, infection is a frequent trigger. Because of the rarity of this disease, the diverse clinical presentation, and the lack of specificity in the clinical and laboratory results, prompt treatment is essential, but the biggest obstacle to a favorable outcome is frequently a delay in identification. CASE REPORT: Here we report a case of a 6-month-old male infant who presented to the dermatology outpatient with disseminated skin lesions present over the face, abdomen, scalp, and bilateral upper and lower limbs for the past month. The lesions were insidious in onset, initially started over the abdomen, and gradually progressed to involve other body parts. The patient also had a history of fever which was moderate in grade, on and off in nature for 1 month. There were no significant complaints in the past, family, or drug history. There was no history of feeding difficulties in the baby. Parents gave a history of developmental milestones appropriate for age. Examination findings include multiple well-defined monomorphic erythematous papules with a central crater present over bilateral cheeks. Few lichenoid shiny papules present over bilateral arms, legs, and abdomen. Ultrasound of the abdomen and pelvis showed mild degree hepatosplenomegaly, intraabdominal lymphadenopathy, and bilateral inguinal lymphadenopathy. Routine blood investigations showed anemia and lymphopenia. Multiple X-rays of the skull, chest, and bilateral upper and lower limbs were done and were normal. Histopathology features were suggestive of non-Langerhans cell cutaneous histiocytosis. CONCLUSION: HLH is a fatal and rare disease. A high level of suspicion and an interdisciplinary approach among experienced clinicians, pathologists, and microbiologists to define the diagnosis and causative disease are key to diagnosing this case. Early detection and treatment can reduce patient morbidity and mortality. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=histiocytosis" title="histiocytosis">histiocytosis</a>, <a href="https://publications.waset.org/abstracts/search?q=non%20langerhans%20cell" title=" non langerhans cell"> non langerhans cell</a>, <a href="https://publications.waset.org/abstracts/search?q=case%20report" title=" case report"> case report</a>, <a href="https://publications.waset.org/abstracts/search?q=fatal" title=" fatal"> fatal</a>, <a href="https://publications.waset.org/abstracts/search?q=rare" title=" rare"> rare</a> </p> <a href="https://publications.waset.org/abstracts/156435/a-rare-case-report-of-non-langerhans-cell-cutaneous-histiocytosis-in-a-6-month-old-infant" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/156435.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">93</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">355</span> Giant Filiform Polyposis in a Patient with Ulcerative Colitis Mimicking Colorectal Cancer</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Godwin%20Dennison">Godwin Dennison</a>, <a href="https://publications.waset.org/abstracts/search?q=Edwin%20Cooper"> Edwin Cooper</a>, <a href="https://publications.waset.org/abstracts/search?q=George%20Theobald"> George Theobald</a>, <a href="https://publications.waset.org/abstracts/search?q=Richard%20Dalton"> Richard Dalton</a> </p> <p class="card-text"><strong>Abstract:</strong></p> We report an unusual case of giant filiform polyposis in a patient with ulcerative colitis, causing a large stricture in the colon. A 62-year-old man was referred to the Bowel Cancer Screening Programme with a positive Faecal Immunochemical Test (FIT). He was known to have UC for 30 years. A CT scan showed a 9 cm stricture in the transverse colon suspicious of malignancy. A colonoscopy was attempted three times, and biopsies confirmed features of ulcerative colitis. A laparoscopic assisted transverse colectomy (Left hemicolectomy) was performed, and the histology revealed giant filiform polyposis. This should be considered in a UC patient presenting with signs of obstruction mimicking a carcinoma. Whilst it is a benign condition, because of the size of the lesion, it often causes obstruction, and surgery is indicated to relieve symptoms. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=giant%20inflammatory%20polyposis" title="giant inflammatory polyposis">giant inflammatory polyposis</a>, <a href="https://publications.waset.org/abstracts/search?q=filiform%20polyposis" title=" filiform polyposis"> filiform polyposis</a>, <a href="https://publications.waset.org/abstracts/search?q=ulcerative%20colitis" title=" ulcerative colitis"> ulcerative colitis</a>, <a href="https://publications.waset.org/abstracts/search?q=inflammatory%20bowel%20disease" title=" inflammatory bowel disease"> inflammatory bowel disease</a> </p> <a href="https://publications.waset.org/abstracts/152067/giant-filiform-polyposis-in-a-patient-with-ulcerative-colitis-mimicking-colorectal-cancer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/152067.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">122</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">354</span> Isolated Hydatidosis of Spleen: A Rare Entity</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Anshul%20Raja">Anshul Raja</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Cystic lesions of the spleen are rare and splenic hydatid cysts account for only 0.5% to 8% of all hydatidosis. Authors hereby report a case where a 50-year-old female presented to our hospital with the complains of heaviness and pain over left upper abdomen over the past 8-10 years. On radiological examination, ultrasonography revealed findings consistent with isolated splenic hydatid cyst and was later on confirmed on Computed Tomography (CT) and Magnetic Resonance Imaging (MRI). No other organ or system involvement was seen. The patient underwent splenectomy and hydatid cyst was confirmed on histopathology. Owing to its rarity, it offers a diagnostic challenge to physicians but can reliably be diagnosed with great confidence employing various imaging modalities like CT and MRI. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=gastrointestinal%20radiology" title="gastrointestinal radiology">gastrointestinal radiology</a>, <a href="https://publications.waset.org/abstracts/search?q=abdominal%20imaging" title=" abdominal imaging"> abdominal imaging</a>, <a href="https://publications.waset.org/abstracts/search?q=hydatid%20cyst" title=" hydatid cyst"> hydatid cyst</a>, <a href="https://publications.waset.org/abstracts/search?q=medical%20and%20health%20sciences" title=" medical and health sciences"> medical and health sciences</a> </p> <a href="https://publications.waset.org/abstracts/18260/isolated-hydatidosis-of-spleen-a-rare-entity" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/18260.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">409</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">353</span> Understanding Neuronal and Glial Cell Behaviour in Multi-Layer Nanofibre Systems to Support the Development of an in vitro Model of Spinal Cord Injury and Personalised Prostheses for Repair </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=H.%20Pegram">H. Pegram</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20Stevens"> R. Stevens</a>, <a href="https://publications.waset.org/abstracts/search?q=L.%20De%20Girolamo"> L. De Girolamo</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Aligned electrospun nanofibres act as effective neuronal and glial cell scaffolds that can be layered to contain multiple sheets harboring different cell populations. This allows personalised biofunctional prostheses to be manufactured with both acellular and cellularised layers for the treatment of spinal cord injury. Additionally, the manufacturing route may be configured to produce in-vitro 3D cell based model of spinal cord injury to aid drug development and enhance prosthesis performance. The goal of this investigation was to optimise the multi-layer scaffold design parameters for prosthesis manufacture, to enable the development of multi-layer patient specific implant therapies. The work has also focused on the fabricating aligned nanofibre scaffolds that promote in-vitro neuronal and glial cell population growth, cell-to-cell interaction and long-term survival following trauma to mimic an in-vivo spinal cord lesion. The approach has established reproducible lesions and has identified markers of trauma and regeneration marked by effective neuronal migration across the lesion with glial support. The investigation has advanced the development of an in-vitro model of traumatic spinal cord injury and has identified a route to manufacture prostheses which target the repair spinal cord injury. Evidence collated to investigate the multi-layer concept suggests that physical cues provided by nanofibres provide both a natural extra-cellular matrix (ECM) like environment and controls cell proliferation and migration. Specifically, aligned nanofibre layers act as a guidance system for migrating and elongating neurons. On a larger scale, material type in multi-layer systems also has an influence in inter-layer migration as cell types favour different material types. Results have shown that layering nanofibre membranes create a multi-level scaffold system which can enhance or prohibit cell migration between layers. It is hypothesised that modifying nanofibre layer material permits control over neuronal/glial cell migration. Using this concept, layering of neuronal and glial cells has become possible, in the context of tissue engineering and also modelling in-vitro induced lesions. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=electrospinning" title="electrospinning">electrospinning</a>, <a href="https://publications.waset.org/abstracts/search?q=layering" title=" layering"> layering</a>, <a href="https://publications.waset.org/abstracts/search?q=lesion" title=" lesion"> lesion</a>, <a href="https://publications.waset.org/abstracts/search?q=modeling" title=" modeling"> modeling</a>, <a href="https://publications.waset.org/abstracts/search?q=nanofibre" title=" nanofibre"> nanofibre</a> </p> <a href="https://publications.waset.org/abstracts/91909/understanding-neuronal-and-glial-cell-behaviour-in-multi-layer-nanofibre-systems-to-support-the-development-of-an-in-vitro-model-of-spinal-cord-injury-and-personalised-prostheses-for-repair" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/91909.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">142</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">352</span> Radiographic Evaluation of Odontogenic Keratocyst: A 14 Years Retrospective Study</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nor%20Hidayah%20Reduwan">Nor Hidayah Reduwan</a>, <a href="https://publications.waset.org/abstracts/search?q=Jira%20Chindasombatjaroen"> Jira Chindasombatjaroen</a>, <a href="https://publications.waset.org/abstracts/search?q=Suchaya%20Pornprasersuk-Damrongsri"> Suchaya Pornprasersuk-Damrongsri</a>, <a href="https://publications.waset.org/abstracts/search?q=Sopee%20Pomsawat"> Sopee Pomsawat</a> </p> <p class="card-text"><strong>Abstract:</strong></p> INTRODUCTION: Odontogenic keratocyst (OKC) remain as a controversial pathologic entity under the scrutiny of many researchers and maxillofacial surgeons alike. The high recurrence rate and relatively aggressive nature of this lesion demand a meticulous analysis of the radiographic characteristic of OKC leading to the formulation of an accurate diagnosis. OBJECTIVE: This study aims to determine the radiographic characteristic of odontogenic keratocyst (OKC) using conventional radiographs and cone beam computed tomography (CBCT) images. MATERIALS AND METHODS: Patients histopathologically diagnosed as OKC from 2003 to 2016 by Oral and Maxillofacial Pathology Department were retrospectively reviewed. Radiographs of these cases from the archives of the Department of Oral and Maxillofacial Radiology, Faculty of Dentistry Mahidol University were retrieved. Assessment of the location, shape, border, cortication, locularity, the relationship of lesion to embedded tooth, displacement of adjacent tooth, root resorption and bony expansion of the lesion were conducted. RESULTS: Radiographs of 91 patients (44 males, 47 females) with the mean age of 31 years old (10 to 84 years) were analyzed. Among all patients, 5 cases were syndromic patients. Hence, a total of 103 OKCs were studied. The most common location was at the ramus of mandible (32%) followed by posterior maxilla (29%). Most cases presented as a well-defined unilocular radiolucency with smooth and corticated border. The lesion was in associated with embedded tooth in 48 lesions (47%). Eighty five percent of embedded tooth are impacted 3rd molar. Thirty-seven percentage of embedded tooth were entirely encapsulated in the lesion. The lesion attached to the embedded tooth at the cementoenamel junction (CEJ) in 40% and extended to part of root in 23% of cases. Teeth displacement and root resorption were found in 29% and 6% of cases, respectively. Bony expansion in bucco-lingual dimension was seen in 63% of cases. CONCLUSION: OKCs were predominant in the posterior region of the mandible with radiographic features of a well-defined, unilocular radiolucency with smooth and corticated margin. The lesions might relate to an embedded tooth by surrounding an entire tooth, attached to the CEJ level or extending to part of root. Bony expansion could be found but teeth displacement and root resorption were not common. These features might help in giving the differential diagnosis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cone%20beam%20computed%20tomography" title="cone beam computed tomography">cone beam computed tomography</a>, <a href="https://publications.waset.org/abstracts/search?q=imaging%20dentistry" title=" imaging dentistry"> imaging dentistry</a>, <a href="https://publications.waset.org/abstracts/search?q=odontogenic%20keratocyst" title=" odontogenic keratocyst"> odontogenic keratocyst</a>, <a href="https://publications.waset.org/abstracts/search?q=radiographic%20features" title=" radiographic features"> radiographic features</a> </p> <a href="https://publications.waset.org/abstracts/91634/radiographic-evaluation-of-odontogenic-keratocyst-a-14-years-retrospective-study" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/91634.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">131</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">351</span> Diagnostic Evaluation of Urinary Angiogenin (ANG) and Clusterin (CLU) as Biomarker for Bladder Cancer</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Marwa%20I.%20Shabayek">Marwa I. Shabayek</a>, <a href="https://publications.waset.org/abstracts/search?q=Ola%20A.%20Said"> Ola A. Said</a>, <a href="https://publications.waset.org/abstracts/search?q=Hanan%20A.%20Attaia"> Hanan A. Attaia</a>, <a href="https://publications.waset.org/abstracts/search?q=Heba%20A.%20Awida"> Heba A. Awida</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Bladder carcinoma is an important worldwide health problem. Both cystoscopy and urine cytology used in detecting bladder cancer suffer from drawbacks where cystoscopy is an invasive method and urine cytology shows low sensitivity in low grade tumors. This study validates easier and less time-consuming techniques to evaluate the value of combined use of angiogenin and clusterin in comparison and combination with voided urine cytology in the detection of bladder cancer patients. This study includes malignant (bladder cancer patients, n= 50), benign (n=20), and healthy (n=20) groups. The studied groups were subjected to cystoscopic examination, detection of bilharzial antibodies, urine cytology, and estimation of urinary angiogenin and clusterin by ELISA. The overall sensitivity and specifcity were 66% and 75% for angiogenin, 70% and 82.5% for clusterin and 46% and 80% for voided urine cytology. Combined sensitivity of angiogenin and clusterin with urine cytology increased from 82 to 88%. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=angiogenin" title="angiogenin">angiogenin</a>, <a href="https://publications.waset.org/abstracts/search?q=bladder%20cancer" title=" bladder cancer"> bladder cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=clusterin" title=" clusterin"> clusterin</a>, <a href="https://publications.waset.org/abstracts/search?q=cytology" title=" cytology"> cytology</a> </p> <a href="https://publications.waset.org/abstracts/1844/diagnostic-evaluation-of-urinary-angiogenin-ang-and-clusterin-clu-as-biomarker-for-bladder-cancer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/1844.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">302</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">350</span> Histopatological Analysis of Vital Organs in Cattle Infected with Lumpy Skin Disease in Rajasthan, India</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Manisha">Manisha</a>, <a href="https://publications.waset.org/abstracts/search?q=Manisha%20Mathur"> Manisha Mathur</a>, <a href="https://publications.waset.org/abstracts/search?q=Jay%20K.%20Desai"> Jay K. Desai</a>, <a href="https://publications.waset.org/abstracts/search?q=Shesh%20Asopa"> Shesh Asopa</a>, <a href="https://publications.waset.org/abstracts/search?q=Manisha%20Mehra"> Manisha Mehra</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The present study was carried out for the comprehensive analysis of lumpy skin disease (LSD) in cattle and to elucidate the histopathology of vital organs in natural outbreaks. Lumpy skin disease (LSD) is a viral infection that primarily affects cattle. It is caused by a Capri pox virus and is characterized by the formation of skin nodules or lesions. For this study, a postmortem of 20 cows who died of Lumpy skin disease in different regions of Rajasthan was conducted. This study aimed to examine a cow's external and internal organs to confirm if lumpy skin disease was the cause of death. Accurate diagnosis is essential for improving disease surveillance, understanding the disease's progression, and informing control measures. Pathological examinations reveal virus-induced changes across organs, while histopathological analyses provide crucial insights into the disease's pathogenesis, aiding in the development of advanced diagnostics and effective prevention strategies. Histopathological examination of nodular skin lesions revealed edema, hyperemia, acanthosis, severe hydropic degeneration/ballooning degeneration, and hyperkeratosis in the epidermis. In the lungs, congestion, oedema, emphysema, and atelectasis were observed grossly. Microscopically changes were suggestive of interstitial pneumonia, suppurative pneumonia, bronchopneumonia post pneumonic fibrosis, and stage of resolution. Grossely liver showed congestion and necrotic foci microscopically in most of the cases, and the liver showed acute viral hepatitis. Microscopically in kidneys, multifocal interstitial nephritis was observed. There was marked interstitial inflammation and zonal fibrosis with cystically dilated tubules and bowman's capsules. Microscopically, most of the heart tissue section showed normal histology with few sarcocysts in between cardiac muscles. In some cases, loss of cross striation, sarcoplasmic vacuolation, fregmentation, and disintegration of cardiac fibres were observed. The present study revealed the characteristic gross and histopathological changes in different organs in natural cases of lumpy skin disease. Further, the disease was confirmed based on the molecular diagnosis and transmission electron microscopy of capripox infection in the affected cattle in the study area. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Capripoxvirus" title="Capripoxvirus">Capripoxvirus</a>, <a href="https://publications.waset.org/abstracts/search?q=lumpy%20skin%20disease" title=" lumpy skin disease"> lumpy skin disease</a>, <a href="https://publications.waset.org/abstracts/search?q=polymerage%20chain%20reaction" title=" polymerage chain reaction"> polymerage chain reaction</a>, <a href="https://publications.waset.org/abstracts/search?q=transmission%20electron%20microscopy" title=" transmission electron microscopy"> transmission electron microscopy</a> </p> <a href="https://publications.waset.org/abstracts/189333/histopatological-analysis-of-vital-organs-in-cattle-infected-with-lumpy-skin-disease-in-rajasthan-india" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/189333.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">35</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">349</span> Neuroendocrine Tumors of the Oral Cavity: A Summarized Overview</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sona%20Babu%20Rathinam">Sona Babu Rathinam</a>, <a href="https://publications.waset.org/abstracts/search?q=Lavanya%20Dharmendran"> Lavanya Dharmendran</a>, <a href="https://publications.waset.org/abstracts/search?q=Therraddi%20Mutthu"> Therraddi Mutthu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Objectives: The purpose of this paper is to provides an overview of the neuroendocrine tumors that arise in the oral cavity. Material and Methods: An overview of the relevant papers on neuroendocrine tumors of the oral cavity by various authors was studied and summarized. Results: On the basis of the relevant studies, this paper provides an overview of the classification and histological differentiation of the neuroendocrine tumors that arise in the oral cavity. Conclusions: The basis of classification of neuroendocrine tumors is largely determined by their histologic differentiation. Though they reveal biologic heterogeneity, there should be an awareness of the occurrence of such lesions in the oral cavity to enable them to be detected and treated early. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=malignant%20peripheral%20nerve%20sheath%20tumor" title="malignant peripheral nerve sheath tumor">malignant peripheral nerve sheath tumor</a>, <a href="https://publications.waset.org/abstracts/search?q=olfactory%20neuroblastoma" title=" olfactory neuroblastoma"> olfactory neuroblastoma</a>, <a href="https://publications.waset.org/abstracts/search?q=paraganglioma" title=" paraganglioma"> paraganglioma</a>, <a href="https://publications.waset.org/abstracts/search?q=schwannoma" title=" schwannoma"> schwannoma</a> </p> <a href="https://publications.waset.org/abstracts/168796/neuroendocrine-tumors-of-the-oral-cavity-a-summarized-overview" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/168796.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">86</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">348</span> Oncological Consequences of Heavy Metal Deposits in Jos East, Plateau State, Nigeria</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jasini%20Waida">Jasini Waida</a>, <a href="https://publications.waset.org/abstracts/search?q=Usman%20Rilwan"> Usman Rilwan</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20I.%20Ikpughul"> S. I. Ikpughul</a>, <a href="https://publications.waset.org/abstracts/search?q=E.%20I.%20Ugwu"> E. I. Ugwu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Carcinogenic substances are those that induce tumours (benign or malignant), increase their incidence or malignancy, or shorten the time of tumour occurrence when they get into the body through inhalation, injection, dermal application, or ingestion. Using X-Ray Fluorescence, this study reveals the accumulation of heavy metals in Jos East. The results of this study showed that the Geo-Accumulation Index (Igeo) of water for different heavy metals decreased in the order of Cd (0.15) > Cr and As (0.03) > Pb (-0.13) > Ni (-0.6). The soil content for different heavy metals decreased in the order of As and Cd (0.4) > Ni, Cr and Pb (0.2). The edible plants for different heavy metals decreased in the order of Cd (0.512) > As (0.25) > Pb (0.23) > Ni (0.01) > Ni (-0.06). 21% of these points are uncontaminated, except for a few points that are found within the uncontaminated to moderately contaminated level. It is possible to conclude that the area is uncontaminated to moderately contaminated, necessitating regulation. Hence, this study can be used as reference data for regulatory bodies like the Nigerian Nuclear Regulatory Authority (NNRA) and the rest. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=heavy%20metals" title="heavy metals">heavy metals</a>, <a href="https://publications.waset.org/abstracts/search?q=soil" title=" soil"> soil</a>, <a href="https://publications.waset.org/abstracts/search?q=plants" title=" plants"> plants</a>, <a href="https://publications.waset.org/abstracts/search?q=water" title=" water"> water</a>, <a href="https://publications.waset.org/abstracts/search?q=contamination%20factor" title=" contamination factor"> contamination factor</a> </p> <a href="https://publications.waset.org/abstracts/164092/oncological-consequences-of-heavy-metal-deposits-in-jos-east-plateau-state-nigeria" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/164092.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">93</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">347</span> Resveratrol and Clobetasol-17-Propionate Co-administration to Manage Oral Lichen Planus: Embedding Actives-Loaded Lipid Microspheres Into a Patient-Friendly Buccal Patch</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Giulia%20Di%20Prima">Giulia Di Prima</a>, <a href="https://publications.waset.org/abstracts/search?q=Maria%20Elena%20Mauceri"> Maria Elena Mauceri</a>, <a href="https://publications.waset.org/abstracts/search?q=Giovanna%20Giuliana"> Giovanna Giuliana</a>, <a href="https://publications.waset.org/abstracts/search?q=Viviana%20De%20Caro"> Viviana De Caro</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Oral Lichen Planus (OLP) is a chronic, non-infectious inflammatory disease of the oral cavity characterized by symmetrical and bilateral lesions or multiple lesions affecting the buccal mucosa, the tongue, and the gingiva, causing severe pain and impairing patients’ quality of life. The conventional OLP treatment involves the topical administration of corticosteroids and clobetasol-17-propionate (CLB) remain the primary therapeutic option, even if there are no commercially available pharmaceutical forms intended for oromucosal application. An underestimated aspect of OLP pathogenesis is the role of oxidative stress. During inflammation, the generation of ROS is significantly enhanced. The latter can cause damage to several cellular components as protein, membrane lipids, nucleic acids, etc., inducing genetic mutations and playing a critical role in the potential malignant degeneration. A recent systematic review of over 1154 studies has demonstrated that antioxidants might not only effectively reduce pain but also increase the disease resolution rate and prevent potentially malignant outcomes. Among natural antioxidants resveratrol (RSV) is a polyphenol that was recently focused by researchers due to its biological actions by which it could be useful in the management of OLP in co-administration with conventional corticosteroids. However, both RSV and CLB suffer from several drawback related to their formulation and administration. Based on these considerations, the aim of this work was to develop novel, personalizable and patient-friendly drug delivery systems for the loco-regional clinical administration of CLB or co-administration of CLB+RSV to treat OLP lesions in order to evaluate both i) the clinical efficacy of stand-alone CLB when administered through a standardizable and innovative formulation instead of the conventionally used ones and ii) the clinical efficacy of the co-administration of the two selected active molecules, in terms of healing rate respect the control group (administration of a conventional CLB-loaded semisolid formulation). To address this issue while also overcoming the limitations of the chosen drugs a microcomposite patch was designed and characterized. Lipid-based microparticles (LMPs) as solid lipid microparticles (SLM) and microstructured lipid carriers (MLC) were then optimized to encapsulate CLB and RSV, respectively. The LMPs were prepared according to a patented technique and were accurately designed to be applied into the oral cavity. They thus resulted suitable in terms of melting temperature range (compliant with the oral temperature) and particle size (<450 μm). Moreover, in view of their next use for the preparation of the final dosage forms, they were further investigated as pharmaceutical intermediate in terms of particle shape and flow properties. Subsequently, two different buccal patches were prepared by dispersing the LMPs into a mucoadhesive hydrophilic gel then subjected to solvent casting: the CLB series patches were loaded only with the SLM-CLB, while the CLB+RSV series patches contained both SLM-CLB and MLC-RSV. Both formulations resulted soft, deformable, homogeneous, reproducible, mucoadhesive, low swellable and potentially comfortable for patients. Finally, their ex vivo ability to promote actives entry into the buccal tissue was also demonstrated, making them promising drug delivery systems for a further clinical trial actually in progress (Oral Medicine Unit, Palermo University Hospital Policlinico “P. Giaccone”). <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=buccal%20patch" title="buccal patch">buccal patch</a>, <a href="https://publications.waset.org/abstracts/search?q=clobetasol-17-propionate" title=" clobetasol-17-propionate"> clobetasol-17-propionate</a>, <a href="https://publications.waset.org/abstracts/search?q=lipid%20microparticles" title=" lipid microparticles"> lipid microparticles</a>, <a href="https://publications.waset.org/abstracts/search?q=oral%20lichen%20planus" title=" oral lichen planus"> oral lichen planus</a>, <a href="https://publications.waset.org/abstracts/search?q=resveratrol" title=" resveratrol"> resveratrol</a> </p> <a href="https://publications.waset.org/abstracts/198245/resveratrol-and-clobetasol-17-propionate-co-administration-to-manage-oral-lichen-planus-embedding-actives-loaded-lipid-microspheres-into-a-patient-friendly-buccal-patch" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/198245.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">15</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">346</span> Morphological Features Fusion for Identifying INBREAST-Database Masses Using Neural Networks and Support Vector Machines </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nadia%20el%20Atlas">Nadia el Atlas</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohammed%20el%20Aroussi"> Mohammed el Aroussi</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohammed%20Wahbi"> Mohammed Wahbi </a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this paper a novel technique of mass characterization based on robust features-fusion is presented. The proposed method consists of mainly four stages: (a) the first phase involves segmenting the masses using edge information’s. (b) The second phase is to calculate and fuse the most relevant morphological features. (c) The last phase is the classification step which allows us to classify the images into benign and malignant masses. In this step we have implemented Support Vectors Machines (SVM) and Artificial Neural Networks (ANN), which were evaluated with the following performance criteria: confusion matrix, accuracy, sensitivity, specificity, receiver operating characteristic ROC, and error histogram. The effectiveness of this new approach was evaluated by a recently developed database: INBREAST database. The fusion of the most appropriate morphological features provided very good results. The SVM gives accuracy to within 64.3%. Whereas the ANN classifier gives better results with an accuracy of 97.5%. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=breast%20cancer" title="breast cancer">breast cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=mammography" title=" mammography"> mammography</a>, <a href="https://publications.waset.org/abstracts/search?q=CAD%20system" title=" CAD system"> CAD system</a>, <a href="https://publications.waset.org/abstracts/search?q=features" title=" features"> features</a>, <a href="https://publications.waset.org/abstracts/search?q=fusion" title=" fusion"> fusion</a> </p> <a href="https://publications.waset.org/abstracts/22407/morphological-features-fusion-for-identifying-inbreast-database-masses-using-neural-networks-and-support-vector-machines" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/22407.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">605</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">345</span> Relationship between Pushing Behavior and Subcortical White Matter Lesion in the Acute Phase after Stroke</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Yuji%20Fujino">Yuji Fujino</a>, <a href="https://publications.waset.org/abstracts/search?q=Kazu%20Amimoto"> Kazu Amimoto</a>, <a href="https://publications.waset.org/abstracts/search?q=Kazuhiro%20Fukata"> Kazuhiro Fukata</a>, <a href="https://publications.waset.org/abstracts/search?q=Masahide%20Inoue"> Masahide Inoue</a>, <a href="https://publications.waset.org/abstracts/search?q=Hidetoshi%20Takahashi"> Hidetoshi Takahashi</a>, <a href="https://publications.waset.org/abstracts/search?q=Shigeru%20Makita"> Shigeru Makita</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Aim: Pusher behavior (PB) is a disorder in which stroke patients shift their body weight toward the affected side of the body (the hemiparetic side) and push away from the non-hemiparetic side. These patients often use further pushing to resist any attempts to correct their position to upright. It is known that the subcortical white matter lesion (SWML) usually correlates of gait or balance function in stroke patients. However, it is unclear whether the SWML influences PB. The purpose of this study was to investigate if the damage of SWML affects the severity of PB on acute stroke patients. Methods: Fourteen PB patients without thalamic or cortical lesions (mean age 73.4 years, 17.5 days from onset) participated in this study. Evaluation of PB was performed according to the Scale for Contraversive Pushing (SCP) for sitting and/or standing. We used modified criteria wherein the SCP subscale scores in each section of the scale were >0. As a clinical measurement, patients were evaluated by the Stroke Impairment Assessment Set (SIAS). For the depiction of SWML, we used T2-weighted fluid-attenuated inversion-recovery imaging. The degree of damage on SWML was assessed using the Fazekas scale. Patients were divided into two groups in the presence of SWML (SWML+ group; Fazekas scale grade 1-3, SWML- group; Fazekas scale grade 0). The independent t-test was used to compare the SCP and SIAS. This retrospective study was approved by the Ethics Committee. Results: In SWML+ group, the SCP was 3.7±1.0 points (mean±SD), the SIAS was 28.0 points (median). In SWML- group, the SCP was 2.0±0.2 points, and the SIAS was 31.5 points. The SCP was significantly higher in SWML+ group than in SWML- group (p<0.05). The SIAS was not significant in both groups (p>0.05). Discussion: It has been considered that the posterior thalamus is the neural structures that process the afferent sensory signals mediating graviceptive information about upright body orientation in humans. Therefore, many studies reported that PB was typically associated with unilateral lesions of the posterior thalamus. However, the result indicates that these extra-thalamic brain areas also contribute to the network controlling upright body posture. Therefore, SMWL might induce dysfunction through malperfusion in distant thalamic or other structurally intact neural structures. This study had a small sample size. Therefore, future studies should be performed with a large number of PB patients. Conclusion: The present study suggests that SWML can be definitely associated with PB. The patients with SWML may be severely incapacitating. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=pushing%20behavior" title="pushing behavior">pushing behavior</a>, <a href="https://publications.waset.org/abstracts/search?q=subcortical%20white%20matter%20lesion" title=" subcortical white matter lesion"> subcortical white matter lesion</a>, <a href="https://publications.waset.org/abstracts/search?q=acute%20phase" title=" acute phase"> acute phase</a>, <a href="https://publications.waset.org/abstracts/search?q=stroke" title=" stroke"> stroke</a> </p> <a href="https://publications.waset.org/abstracts/50370/relationship-between-pushing-behavior-and-subcortical-white-matter-lesion-in-the-acute-phase-after-stroke" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/50370.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">247</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">344</span> Dose Saving and Image Quality Evaluation for Computed Tomography Head Scanning with Eye Protection</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Yuan-Hao%20Lee">Yuan-Hao Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Chia-Wei%20Lee"> Chia-Wei Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Ming-Fang%20Lin"> Ming-Fang Lin</a>, <a href="https://publications.waset.org/abstracts/search?q=Tzu-Huei%20Wu"> Tzu-Huei Wu</a>, <a href="https://publications.waset.org/abstracts/search?q=Chih-Hsiang%20Ko"> Chih-Hsiang Ko</a>, <a href="https://publications.waset.org/abstracts/search?q=Wing%20P.%20Chan"> Wing P. Chan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Computed tomography (CT) scan of the head is a good method for investigating cranial lesions. However, radiation-induced oxidative stress can be accumulated in the eyes and promote carcinogenesis and cataract. In this regard, we aimed to protect the eyes with barium sulfate shield(s) during CT scans and investigate the resultant image quality and radiation dose to the eye. Patients who underwent health examinations were selectively enrolled in this study in compliance with the protocol approved by the Ethics Committee of the Joint Institutional Review Board at Taipei Medical University. Participants’ brains were scanned with a water-based marker simultaneously by a multislice CT scanner (SOMATON Definition Flash) under a fixed tube current-time setting or automatic tube current modulation (TCM). The lens dose was measured by Gafchromic films, whose dose response curve was previously fitted using thermoluminescent dosimeters, with or without barium sulfate or bismuth-antimony shield laid above. For the assessment of image quality CT images at slice planes that exhibit the interested regions on the zygomatic, orbital and nasal bones of the head phantom as well as the water-based marker were used for calculating the signal-to-noise and contrast-to-noise ratios. The application of barium sulfate and bismuth-antimony shields decreased 24% and 47% of the lens dose on average, respectively. Under topogram-based TCM, the dose saving power of bismuth-antimony shield was mitigated whereas that of barium sulfate shield was enhanced. On the other hand, the signal-to-noise and contrast-to-noise ratios of DSCT images were decreased separately by barium sulfate and bismuth-antimony shield, resulting in an overall reduction of the CNR. In contrast, the integration of topogram-based TCM elevated signal difference between the ROIs on the zygomatic bones and eyeballs while preferentially decreasing the signal-to-noise ratios upon the use of barium sulfate shield. The results of this study indicate that the balance between eye exposure and image quality can be optimized by combining eye shields with topogram-based TCM on the multislice scanner. Eye shielding could change the photon attenuation characteristics of tissues that are close to the shield. The application of both shields on eye protection hence is not recommended for seeking intraorbital lesions. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=computed%20tomography" title="computed tomography">computed tomography</a>, <a href="https://publications.waset.org/abstracts/search?q=barium%20sulfate%20shield" title=" barium sulfate shield"> barium sulfate shield</a>, <a href="https://publications.waset.org/abstracts/search?q=dose%20saving" title=" dose saving"> dose saving</a>, <a href="https://publications.waset.org/abstracts/search?q=image%20quality" title=" image quality"> image quality</a> </p> <a href="https://publications.waset.org/abstracts/66221/dose-saving-and-image-quality-evaluation-for-computed-tomography-head-scanning-with-eye-protection" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/66221.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">271</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">343</span> Intelligent Prediction of Breast Cancer Severity</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Wahab%20Ali">Wahab Ali</a>, <a href="https://publications.waset.org/abstracts/search?q=Oyebade%20K.%20Oyedotun"> Oyebade K. Oyedotun</a>, <a href="https://publications.waset.org/abstracts/search?q=Adnan%20Khashman"> Adnan Khashman </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Breast cancer remains a threat to the woman’s world in view of survival rates, it early diagnosis and mortality statistics. So far, research has shown that many survivors of breast cancer cases are in the ones with early diagnosis. Breast cancer is usually categorized into stages which indicates its severity and corresponding survival rates for patients. Investigations show that the farther into the stages before diagnosis the lesser the chance of survival; hence the early diagnosis of breast cancer becomes imperative, and consequently the application of novel technologies to achieving this. Over the year, mammograms have used in the diagnosis of breast cancer, but the inconclusive deductions made from such scans lead to either false negative cases where cancer patients may be left untreated or false positive where unnecessary biopsies are carried out. This paper presents the application of artificial neural networks in the prediction of severity of breast tumour (whether benign or malignant) using mammography reports and other factors that are related to breast cancer. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=breast%20cancer" title="breast cancer">breast cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=intelligent%20classification" title=" intelligent classification"> intelligent classification</a>, <a href="https://publications.waset.org/abstracts/search?q=neural%20networks" title=" neural networks"> neural networks</a>, <a href="https://publications.waset.org/abstracts/search?q=mammography" title=" mammography"> mammography</a> </p> <a href="https://publications.waset.org/abstracts/25662/intelligent-prediction-of-breast-cancer-severity" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/25662.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">500</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">342</span> Thulium Laser Vaporisation and Enucleation of Prostate in Patients on Anticoagulants and Antiplatelet Agents</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Abdul%20Fatah">Abdul Fatah</a>, <a href="https://publications.waset.org/abstracts/search?q=Naveenchandra%20Acharya"> Naveenchandra Acharya</a>, <a href="https://publications.waset.org/abstracts/search?q=Vamshi%20Krishna"> Vamshi Krishna</a>, <a href="https://publications.waset.org/abstracts/search?q=T.%20Shivaprasad"> T. Shivaprasad</a>, <a href="https://publications.waset.org/abstracts/search?q=Ramesh%20Ramayya"> Ramesh Ramayya </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Significant number of patients with bladder outlet obstruction due to BPH are on anti-platelets and anticoagulants. Prostate surgery in this group of patients either in the form of TURP or Open prostatectomy is associated with increased risk of bleeding complications requiring transfusions, packing of the prostatic fossa or ligation or embolization of internal iliac arteries. Withholding of antiplatelets and anticoagulants may be associated with cardiac and other complications. Efficacy of Thulium Laser in the above group of patients was evaluated in terms of peri-operative, postoperative and delayed bleeding complications as well as cardiac events in peri-operative and immediate postoperative period. Methods: 217 patients with a mean age of 68.8 years were enrolled between March 2009 and March 2013 (36 months), and treated for BPH with ThuLEP. Every patient was evaluated at base line according to: Digital Rectal Examination (DRE), prostate volume, Post-Voided volume (PVR), International Prostate Symptoms Score (I-PSS), PSA values, urine analysis and urine culture, uroflowmetry. The post operative complications in the form of drop in hemoglobin level, transfusion rates, post –operative cardiac events within a period of 30 days, delayed hematuria and events like deep vein thrombosis and pulmonary embolism were noted. Results: Our data showed a better post-operative outcome in terms of, postoperative bleeding requiring intervention 7 (3.2%), transfusion rate 4 (1.8%) and cardiac events within a period of 30 days 4(1.8%), delayed hematuria within 6 months 2(0.9 %) compared other series of prostatectomies. Conclusion: The thulium LASER prostatectomy is a safe and effective option for patients with cardiac comorbidties and those patients who are on antiplatelet agents and anticoagulants. The complication rate is less as compared to larger series reported with open and transurethral prostatectomies. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=thulium%20laser" title="thulium laser">thulium laser</a>, <a href="https://publications.waset.org/abstracts/search?q=prostatectomy" title=" prostatectomy"> prostatectomy</a>, <a href="https://publications.waset.org/abstracts/search?q=antiplatelet%20agents" title=" antiplatelet agents"> antiplatelet agents</a>, <a href="https://publications.waset.org/abstracts/search?q=bleeding" title=" bleeding"> bleeding</a> </p> <a href="https://publications.waset.org/abstracts/2182/thulium-laser-vaporisation-and-enucleation-of-prostate-in-patients-on-anticoagulants-and-antiplatelet-agents" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/2182.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 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